lignans has been researched along with 7-nitroindazole* in 1 studies
1 other study(ies) available for lignans and 7-nitroindazole
| Article | Year |
|---|---|
Effects of 7-nitroindazole on long-term potentiation induced by l-clausenamide and high-frequency stimulation in rat hippocampus in vivo.
To study the antagonistic effect of selective neuronal nitric-oxide synthase (nNOS) inhibitor 7-nitroindazole on the long-term potentiation (LTP) induced by l-clausenamide (Cla) in rat hippocampus in vivo.. Population spike (PS) of evoked potentials was determined by extracellular recording technique in the hippocampal dentate gyrus (DG) of anesthetized rats.. 7-Nitroindazole 2 nmol icv blocked the induction of LTP elicited by high-frequency (100 Hz) stimulation or Cla 5 nmol icv (P < 0.01), and L-arginine 225 mg.kg-1 i.p. prevented the action of 7-nitroindazole (P < 0.01).. Nitric oxide produced by nNOS plays a role in the induction of Cla-induced LTP in hippocampus. Topics: Animals; Dentate Gyrus; Drugs, Chinese Herbal; Evoked Potentials; Indazoles; Lactams; Lignans; Long-Term Potentiation; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1999 |