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lifibrol and 1-butanol

lifibrol has been researched along with 1-butanol in 16 studies

*1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1. [MeSH]

*1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1. [MeSH]

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's11 (68.75)18.2507
2000's3 (18.75)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hasibeder, H; Heibel, B; März, W; Schmidle, G; Seibel, K; Staab, HJ1
Lang, G; Löser, R; Rattel, B; Schliack, M; Seibel, K1
Blay, KH; Löser, R; Schliack, M; Seibel, K1
Gross, W; Löser, R; März, W; Scharnagl, H; Schliack, M1
Francom, SF; Hughes, GS; Jungbluth, GL; Locker, PK1
Augustin, J; Elsässer, R; Gertz, B; Heil, M; Schmidt, C; Schwandt, P; Seibel, K1
Bell, FP; St John, LC1
Hsu, CY; Walters, RR1
Bell, FP1
Bell, FP; Feenstra, KL; Sanders, PE; Slatter, JG; Sun, EL; Ulrich, RG1
Friedrich, I; Klima, B; Köster, W; März, W; Nuber, C; Sattler, A; Schäfer, JR; Steinmetz, A; Wieland, H; Winkler, K1
Adams-Huet, B; Blumenschein, S; Carter, NB; Grundy, SM; Laeis, P; Lindenthal, B; Lutjohann, D; Simatupang, A; Vega, GL; von Bergmann, J; von Bergmann, K1
Burger, A; Lettenbichler, A1
Friedrich, I; Gierens, H; Klima, B; Köster, W; März, W; Nuber, C; Schaefer, JR; Scharnagl, H; Soufi, M; Wieland, H; Winkler, K1
Gierens, H; Gross, W; Jeck, N; Löser, R; März, W; Nauck, M; Scharnagl, H; Schliack, M; Wieland, H1
Berthold, HK; Gouni-Berthold, I; Sudhop, T; von Bergmann, K1

Trials

7 trial(s) available for lifibrol and 1-butanol

ArticleYear
Clinical pharmacology of the hypocholesterolemic agent K 12.148 (lifibrol) in healthy volunteers.
    European journal of clinical pharmacology, 1991, Volume: 40 Suppl 1

    Topics: Adolescent; Adult; Butanols; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hydroxybenzoates; Hypolipidemic Agents; Male; Molecular Structure; Random Allocation; Reference Values

1991
Lifibrol: a novel lipid-lowering drug for the therapy of hypercholesterolemia. Lifibrol Study Group.
    Clinical pharmacology and therapeutics, 1995, Volume: 57, Issue:1

    Topics: Adolescent; Adult; Aged; Apolipoproteins; Bile Acids and Salts; Butanols; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxybenzoates; Hypercholesterolemia; Hypolipidemic Agents; Male; Middle Aged; Sex Factors; Sterols

1995
Safety and efficacy of lifibrol upon four-week administration to patients with primary hypercholesterolaemia.
    European journal of clinical pharmacology, 1994, Volume: 47, Issue:2

    Topics: Anticholesteremic Agents; Butanols; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxybenzoates; Hypercholesterolemia; Lipids; Male; Middle Aged; Triglycerides

1994
Lifibrol enhances the low density lipoprotein apolipoprotein B-100 turnover in patients with hypercholesterolemia and mixed hyperlipidemia.
    Atherosclerosis, 1999, Volume: 144, Issue:1

    Topics: Adult; Anticholesteremic Agents; Apolipoproteins B; Butanols; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybenzoates; Hypercholesterolemia; Hyperlipidemias; Lipoproteins, LDL; Male; Middle Aged; Statistics, Nonparametric; Treatment Outcome

1999
Effect of lifibrol on the metabolism of low density lipoproteins and cholesterol.
    Journal of internal medicine, 1999, Volume: 246, Issue:1

    Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Butanols; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxybenzoates; Hypercholesterolemia; Hypolipidemic Agents; Male; Mevalonic Acid; Middle Aged; Simvastatin; Single-Blind Method; Triglycerides

1999
HDL steady state levels are not affected, but HDL apoA-I turnover is enhanced by Lifibrol in patients with hypercholesterolemia and mixed hyperlipidemia.
    Atherosclerosis, 2000, Volume: 150, Issue:1

    Topics: Adult; Apolipoprotein A-I; Butanols; Cholesterol, HDL; Humans; Hydroxybenzoates; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type V; Hypolipidemic Agents; Male; Middle Aged

2000
Lifibrol as a model compound for a novel lipid-lowering mechanism of action.
    Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:4

    Topics: Adult; Anticholesteremic Agents; Apolipoprotein B-100; Butanols; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Double-Blind Method; Humans; Hydroxybenzoates; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lipoproteins, LDL; Male; Pravastatin; Triglycerides; Young Adult

2010

Other Studies

9 other study(ies) available for lifibrol and 1-butanol

ArticleYear
The hypolipidemic effect of lifibrol during a long term treatment of pigs.
    Artery, 1990, Volume: 18, Issue:1

    Topics: Alanine Transaminase; Animals; Anticholesteremic Agents; Aspartate Aminotransferases; Body Weight; Butanols; Cholesterol; Female; Hydroxybenzoates; Hypolipidemic Agents; Male; Sex Factors; Swine; Swine, Miniature; Time Factors; Triglycerides

1990
Hypolipemic activity of K12.148 in rats, marmosets and pigs.
    Artery, 1989, Volume: 16, Issue:2

    Topics: Animals; Butanols; Callithrix; Cholesterol; Cholesterol, LDL; Female; Hydroxybenzoates; Liver; Male; Rats; Rats, Inbred Strains; Swine; Triglycerides

1989
A novel assay for cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity using reversed-phase ion-pair chromatography: demonstration that Lifibrol (K12.148) modulates the enzyme activity.
    Journal of lipid research, 1995, Volume: 36, Issue:3

    Topics: Animals; Butanols; Chickens; Chromatography, Ion Exchange; Cytosol; Hydroxybenzoates; Hydroxymethylglutaryl-CoA Synthase; Hypolipidemic Agents; Liver

1995
Action of the new hypolipidemic agent lifibrol (K12.148) on lipid homeostasis in normal rats: plasma lipids, hepatic sterologenesis, and the fate of injected [14C]acetate.
    Lipids, 1993, Volume: 28, Issue:12

    Topics: Acetates; Animals; Butanols; Homeostasis; Hydroxybenzoates; Hypolipidemic Agents; In Vitro Techniques; Injections, Intraperitoneal; Lipid Metabolism; Lipids; Liver; Male; Rats; Rats, Sprague-Dawley; Reference Values; Sterols

1993
Chiral assay methods for lifibrol and metabolites in plasma and the observation of unidirectional chiral inversion following administration of the enantiomers to dogs.
    Chirality, 1994, Volume: 6, Issue:2

    Topics: Administration, Oral; Animals; Autoanalysis; Biological Availability; Butanols; Chromatography, High Pressure Liquid; Dogs; Female; Hydroxybenzoates; Hypolipidemic Agents; Injections, Intravenous; Male; Robotics; Spectrophotometry, Ultraviolet; Stereoisomerism

1994
Effect of the lipid-lowering drug lifibrol on lipid metabolism in rat macrophages and in atherosclerotic arteries from swine and WHHL rabbits, in vitro. Implications in atherogenesis.
    Biochemical pharmacology, 1993, Oct-19, Volume: 46, Issue:8

    Topics: Acetates; Animals; Aorta; Arteries; Arteriosclerosis; Butanols; Carbon Radioisotopes; Cholesterol; Hydroxybenzoates; Hyperlipidemias; Hypolipidemic Agents; Lipids; Macrophages, Peritoneal; Male; Oleic Acid; Oleic Acids; Rabbits; Rats; Rats, Sprague-Dawley; Swine

1993
Biotransformation of lifibrol (U-83860) to mixed glyceride metabolites by rat and human hepatocytes in primary culture.
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:2

    Topics: Animals; Anticholesteremic Agents; Biotransformation; Butanols; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Glycerides; Humans; Hydroxybenzoates; Liver; Male; Mass Spectrometry; Molecular Structure; Radioligand Assay; Rats; Rats, Wistar

1996
Polymorphism and preformulation studies of lifibrol.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2000, Volume: 49, Issue:1

    Topics: Anticholesteremic Agents; Butanols; Chemistry, Pharmaceutical; Drug Stability; Hydroxybenzoates

2000
The effects of lifibrol (K12.148) on the cholesterol metabolism of cultured cells: evidence for sterol independent stimulation of the LDL receptor pathway.
    Atherosclerosis, 2000, Volume: 153, Issue:1

    Topics: Anticholesteremic Agents; Butanols; Cell Line; Cholesterol; Dose-Response Relationship, Drug; Humans; Hydroxybenzoates; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Prodrugs; Receptors, LDL; Sterols

2000