Page last updated: 2024-09-04

lidorestat and zopolrestat

lidorestat has been researched along with zopolrestat in 2 studies

Compound Research Comparison

Studies
(lidorestat)
Trials
(lidorestat)
Recent Studies (post-2010)
(lidorestat)
Studies
(zopolrestat)
Trials
(zopolrestat)
Recent Studies (post-2010) (zopolrestat)
60286224

Protein Interaction Comparison

ProteinTaxonomylidorestat (IC50)zopolrestat (IC50)
Aldo-keto reductase family 1 member B10Homo sapiens (human)0.915
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.0153
Aldo-keto reductase family 1 member A1Homo sapiens (human)1.3545
Aldo-keto reductase family 1 member B1Homo sapiens (human)0.0229
Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)0.005
Aldo-keto reductase family 1 member B7Rattus norvegicus (Norway rat)0.049

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dicioccio, AT; Geraci, LS; Gunn, DE; Jacot, JL; Jones, JH; Jones, ML; Mitschler, A; Petrova, T; Podjarny, AD; Sawicki, DR; Sredy, J; Van Zandt, MC1
Heine, A; Klebe, G; Majekova, M; Rechlin, C; Soltesova Prnova, M; Stefek, M1

Other Studies

2 other study(ies) available for lidorestat and zopolrestat

ArticleYear
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complications; Diabetes Mellitus, Experimental; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Structure-Activity Relationship; Thiazoles; Tissue Distribution

2005
Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold.
    Journal of medicinal chemistry, 2015, Mar-26, Volume: 58, Issue:6

    Topics: Acetic Acid; Aldehyde Reductase; Animals; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Wistar; Sorbitol; Structure-Activity Relationship; Sulfhydryl Compounds

2015