Page last updated: 2024-09-04

lidorestat and zopolrestat

lidorestat has been researched along with zopolrestat in 2 studies

Compound Research Comparison

Studies (lidorestat)	Trials (lidorestat)	Recent Studies (post-2010) (lidorestat)	Studies (zopolrestat)	Trials (zopolrestat)	Recent Studies (post-2010) (zopolrestat)
6	0	2	86	2	24

Protein Interaction Comparison

Protein	Taxonomy	zopolrestat (IC50)
Aldo-keto reductase family 1 member B10	Homo sapiens (human)	0.915
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	0.0153
Aldo-keto reductase family 1 member A1	Homo sapiens (human)	1.3545
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	0.0229
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	0.005
Aldo-keto reductase family 1 member B7	Rattus norvegicus (Norway rat)	0.049

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dicioccio, AT; Geraci, LS; Gunn, DE; Jacot, JL; Jones, JH; Jones, ML; Mitschler, A; Petrova, T; Podjarny, AD; Sawicki, DR; Sredy, J; Van Zandt, MC	1
Heine, A; Klebe, G; Majekova, M; Rechlin, C; Soltesova Prnova, M; Stefek, M	1

Other Studies

2 other study(ies) available for lidorestat and zopolrestat

Article	Year
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complications; Diabetes Mellitus, Experimental; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Structure-Activity Relationship; Thiazoles; Tissue Distribution	2005
Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold. Journal of medicinal chemistry, 2015, Mar-26, Volume: 58, Issue:6 Topics: Acetic Acid; Aldehyde Reductase; Animals; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Wistar; Sorbitol; Structure-Activity Relationship; Sulfhydryl Compounds	2015

Article

Year

Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.

Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complications; Diabetes Mellitus, Experimental; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Structure-Activity Relationship; Thiazoles; Tissue Distribution

2005

Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold.

Journal of medicinal chemistry, 2015, Mar-26, Volume: 58, Issue:6

Topics: Acetic Acid; Aldehyde Reductase; Animals; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Wistar; Sorbitol; Structure-Activity Relationship; Sulfhydryl Compounds

2015