lidorestat has been researched along with zopolrestat in 2 studies
Studies (lidorestat) | Trials (lidorestat) | Recent Studies (post-2010) (lidorestat) | Studies (zopolrestat) | Trials (zopolrestat) | Recent Studies (post-2010) (zopolrestat) |
---|---|---|---|---|---|
6 | 0 | 2 | 86 | 2 | 24 |
Protein | Taxonomy | lidorestat (IC50) | zopolrestat (IC50) |
---|---|---|---|
Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | 0.915 | |
Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.0153 | |
Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | 1.3545 | |
Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | 0.0229 | |
Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | 0.005 | |
Aldo-keto reductase family 1 member B7 | Rattus norvegicus (Norway rat) | 0.049 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (50.00) | 29.6817 |
2010's | 1 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Dicioccio, AT; Geraci, LS; Gunn, DE; Jacot, JL; Jones, JH; Jones, ML; Mitschler, A; Petrova, T; Podjarny, AD; Sawicki, DR; Sredy, J; Van Zandt, MC | 1 |
Heine, A; Klebe, G; Majekova, M; Rechlin, C; Soltesova Prnova, M; Stefek, M | 1 |
2 other study(ies) available for lidorestat and zopolrestat
Article | Year |
---|---|
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complications; Diabetes Mellitus, Experimental; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Structure-Activity Relationship; Thiazoles; Tissue Distribution | 2005 |
Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold.
Topics: Acetic Acid; Aldehyde Reductase; Animals; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Wistar; Sorbitol; Structure-Activity Relationship; Sulfhydryl Compounds | 2015 |