lidocaine and theophylline

lidocaine has been researched along with theophylline in 73 studies

Research

Studies (73)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (38.36)	18.7374
1990's	5 (6.85)	18.2507
2000's	17 (23.29)	29.6817
2010's	22 (30.14)	24.3611
2020's	1 (1.37)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Caron, G; Ermondi, G	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bajda, M; Brus, B; Gobec, S; Guzior, N; Malawska, B; Rakoczy, J	1
Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bienkowski, P; Bucki, A; Gobec, S; Godyń, J; Głuch-Lutwin, M; Kazek, G; Knez, D; Kołaczkowski, M; Malawska, B; Marcinkowska, M; Mierzejewski, P; Sienkiewicz-Jarosz, H; Siwek, A; Wichur, T; Więckowska, A; Więckowski, K; Zaręba, P	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Brazzolotto, X; Brus, B; Colletier, JP; Coquelle, N; Gobec, S; Knez, D; Kos, J; Košak, U; Nachon, F; Pišlar, A	1
Elkamhawy, A; Hassan, AHE; Lee, J; Moon, B; Pae, AN; Park, BG; Park, HM; Park, JE; Ra, H; Roh, EJ	1
Chłoń-Rzepa, G; Dąbrowska, M; Jankowska, A; Komsta, Ł; Pawłowski, M; Ślusarczyk, M; Starek, M; Zagórska, A	1
Bond, WS	1
Forsberg, K; Karlsson, JA; Persson, CG; Zackrisson, C	1
Erjefält, I; Persson, CG	1
Lucas, ML; McEwan, GT	1
Gustafsson, LE; Samuelson, UE; Wiklund, NP	1
Kovaliv, IB; Kovaliv, IuM; Temnik, IV; Trotsenko, OV	1
Buccino, G; Cocciolo, M; Colli, A; Parravicini, R; Scaltrini, G	1
Kimelski, R	1
Kreeft, JH; Sebaldt, RJ	1
Devine, JE	1
Coleman, RA; Levy, GP	1
Inesi, G; Johnson, PN	1
Kośmider, S; Smolarz, W	1
Stange, G	1
Downes, H; Taylor, SM	1
Sedman, AJ	1
Greene, W	1
Bach, PR; Larsen, JW	1
Stirt, JA; Sullivan, SF	1
Cassuto, J; Eklund, S; Jodal, M; Lundgren, O	1
Gorsky, JE	1
D'Arcy, PF	1
DiGregorio, GJ; Fruncillo, RJ	1
Lesko, LJ; Turo, TT	1
Higuchi, T; Nishihata, T; Rytting, JH	2
Zenk, KE	1
Nolte, D	1
Chen, ML; Chiou, WL; Lam, G; Lee, MG	1
Ahrens, R; Spector, R	1
Ishikawa, A; Misawa, S; Tanaka, E	1
Muszynski, MJ; Rajyaguru, JM	1
Kordasti, S; Lundgren, O; Peregrin, AT; Persson, K; Svensson, L; Uhnoo, I	1
Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E	1
Juvekar, AR; Shah, KJ	1
De Martin, S; Orlando, R; Palatini, P; Pegoraro, P	1
Edginton, AN; Willmann, S	1
Burki, NK; Lee, LY	1
Al Musa, T; El-Tawil, S; El-Tawil, T; Lunn, MP; Valli, H; Weber, M	1
Danède, F; Delplace, C; Descamps, M; Klose, D; Kreye, F; Siepmann, F; Siepmann, J	1
Al Musa, T; Brassington, R; El-Tawil, S; El-Tawil, T; Lunn, MP; Valli, H; Weber, M	1
Chiba, K; Haraya, K; Kato, M; Sugiyama, Y	1
Bandari, S; Kallakunta, VR; Kim, DW; Patil, H; Repka, MA; Sarabu, S; Tiwari, R; Upadhye, S; Vladyka, RS; Ye, X	1

Reviews

11 review(s) available for lidocaine and theophylline

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Euphylline as a stimulant of gastric secretion (a review of the literature)]. Vrachebnoe delo, 1986, Issue:2 Topics: Adult; Aminophylline; Calcium Gluconate; Child; Cyclic AMP; Dose-Response Relationship, Drug; Gastric Acid; Gastric Juice; Gastric Mucosa; Histamine; Humans; Lidocaine; Stimulation, Chemical; Theophylline	1986
[Interaction between smoking and drugs]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1986, Jan-01, Volume: 39, Issue:1 Topics: Contraceptives, Oral; Humans; Kinetics; Lidocaine; Pharmaceutical Preparations; Phenylbutazone; Propranolol; Smoking; Theophylline	1986
Cimetidine-drug interactions. The American journal of medicine, 1984, Volume: 76, Issue:1 Topics: Adrenergic beta-Antagonists; Anticonvulsants; Benzodiazepines; Chlormethiazole; Cimetidine; Drug Interactions; Humans; Ketoconazole; Kidney; Lidocaine; Morphine; Penicillins; Theophylline	1984
Drug interactions involving cimetidine--mechanisms, documentation, implications. Quarterly reviews on drug metabolism and drug interactions, 1984, Volume: 5, Issue:1 Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antacids; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifungal Agents; Aspirin; Benzodiazepines; Cimetidine; Digoxin; Drug Interactions; Humans; Intestinal Absorption; Iron; Lidocaine; Pancreas; Phenytoin; Prednisolone; Theophylline; Vitamin B 12	1984
Aminophylline. Anesthesia and analgesia, 1981, Volume: 60, Issue:8 Topics: Adult; Aminophylline; Anesthesia; Animals; Anticonvulsants; Arrhythmias, Cardiac; Asthma; Biotransformation; Brain; Breast Feeding; Cardiovascular System; Cats; Cattle; Cyclic AMP; Dogs; Female; Humans; Infant, Newborn; Lidocaine; Maternal-Fetal Exchange; Mice; Pregnancy; Protein Binding; Rats; Respiratory System; Seizures; Theophylline	1981
Tobacco smoking and drugs: a clinically important interaction? Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:4 Topics: Acetaminophen; Animals; Dextropropoxyphene; Drug Interactions; Enzyme Induction; Glutethimide; Humans; Insulin; Lidocaine; Microsomes, Liver; Mixed Function Oxygenases; Pentazocine; Pharmaceutical Preparations; Phenacetin; Phenylbutazone; Propranolol; Smoking; Theophylline	1984
An overview of perinatal clinical pharmacology. Clinics in laboratory medicine, 1981, Volume: 1, Issue:2 Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digoxin; Female; Fetus; Furosemide; Gentamicins; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Penicillins; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Tetracycline; Theophylline	1981
Enzyme inhibition and induction in liver disease. Current clinical pharmacology, 2008, Volume: 3, Issue:1 Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Fluvoxamine; Humans; Lidocaine; Liver; Liver Diseases; Theophylline	2008
Quinine for muscle cramps. The Cochrane database of systematic reviews, 2010, Dec-08, Issue:12 Topics: Drug Therapy, Combination; Humans; Lidocaine; Muscle Cramp; Muscle Relaxants, Central; Quinine; Randomized Controlled Trials as Topic; Theophylline; Vitamin E; Vitamins	2010
Quinine for muscle cramps. The Cochrane database of systematic reviews, 2015, Apr-05, Issue:4 Topics: Drug Therapy, Combination; Humans; Lidocaine; Muscle Cramp; Muscle Relaxants, Central; Quinine; Randomized Controlled Trials as Topic; Theophylline; Vitamin E; Vitamins	2015

Trials

1 trial(s) available for lidocaine and theophylline

Article	Year
Blockade of airway sensory nerves and dyspnea in humans. Pulmonary pharmacology & therapeutics, 2010, Volume: 23, Issue:4 Topics: Adolescent; Adult; Anesthetics, Local; Double-Blind Method; Dyspnea; Female; Humans; Lidocaine; Male; Middle Aged; Nerve Block; Nerve Fibers, Unmyelinated; Purinergic P1 Receptor Antagonists; Sodium Channels; Theophylline; Vagus Nerve; Young Adult	2010

Other Studies

61 other study(ies) available for lidocaine and theophylline

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents. Bioorganic & medicinal chemistry, 2015, Apr-01, Volume: 23, Issue:7 Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Drug Delivery Systems; Drug Design; Drug Evaluation, Preclinical; Horses; Humans; Indoles; Protein Structure, Secondary	2015
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo. Bioorganic & medicinal chemistry, 2015, May-15, Volume: 23, Issue:10 Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Humans; Indans; Indoles; Male; Memory; Mice; Models, Molecular; Neuroprotective Agents; Phthalimides; Piperidines; Protein Aggregates; Scopolamine; Structure-Activity Relationship	2015
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT European journal of medicinal chemistry, 2016, Nov-29, Volume: 124 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Ligands; Male; Models, Molecular; Molecular Targeted Therapy; Protein Conformation; Rats; Rats, Wistar; Receptors, Serotonin	2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents. Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Death; Cell Line; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Naphthalenes; Peptide Fragments; Piperidines; Structure-Activity Relationship; Sulfonamides	2017
Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction. European journal of medicinal chemistry, 2017, Mar-10, Volume: 128 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Cyclosporine; Drug Discovery; Hippocampus; Immunosuppressive Agents; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Molecular Docking Simulation; Neurons; Piperazines; Protein Conformation; Urea	2017
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity. Bioorganic & medicinal chemistry letters, 2021, 10-01, Volume: 49 Topics: Analgesics; Benzeneacetamides; Cyclic Nucleotide Phosphodiesterases, Type 7; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Phenylbutyrates; Phosphodiesterase 4 Inhibitors; Principal Component Analysis; Quantitative Structure-Activity Relationship; TRPA1 Cation Channel; Xanthines	2021
Clinical relevance of the effect of hepatic disease on drug disposition. American journal of hospital pharmacy, 1978, Volume: 35, Issue:4 Topics: Anti-Infective Agents; Antineoplastic Agents; Central Nervous System; Digoxin; Humans; Lidocaine; Liver Diseases; Pharmaceutical Preparations; Phenylbutazone; Prednisone; Theophylline	1978
Selective inhibition of cough and bronchoconstriction in conscious guinea pigs. Respiration; international review of thoracic diseases, 1992, Volume: 59, Issue:2 Topics: Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Citrates; Citric Acid; Cough; Female; Guinea Pigs; Ipratropium; Lidocaine; Male; Terbutaline; Theophylline; Xanthines	1992
Pharmacologic control of plasma exudation into tracheobronchial airways. The American review of respiratory disease, 1991, Volume: 143, Issue:5 Pt 1 Topics: Animals; Asthma; Bronchi; Bronchodilator Agents; Capillary Permeability; Cromolyn Sodium; Guinea Pigs; Lidocaine; Male; Plasma; Terbutaline; Theophylline; Trachea; Xanthines	1991
The effect of E. coli STa enterotoxin on the absorption of weakly dissociable drugs from rat proximal jejunum in vivo. British journal of pharmacology, 1990, Volume: 101, Issue:4 Topics: Amphetamine; Animals; Bacterial Toxins; Colforsin; Electrolytes; Enterotoxins; Escherichia coli; Escherichia coli Proteins; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Lidocaine; Male; Morphine; Perfusion; Phenytoin; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Theophylline	1990
Dual effects of adenosine and adenosine analogues on motor activity of the human fallopian tube. Acta physiologica Scandinavica, 1985, Volume: 125, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Fallopian Tubes; Female; Humans; Lidocaine; Menstruation; Middle Aged; Muscle Contraction; Muscle, Smooth; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Tetrodotoxin; Theophylline	1985
Disposition of a flow-limited drug (lidocaine) and a metabolic capacity-limited drug (theophylline) in liver cirrhosis. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:6 Topics: Adult; Aged; Female; Humans; Hypertension, Portal; Lidocaine; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Portal System; Theophylline	1988
Efficient pharmacokinetic modeling of complex clinical dosing regimens: the universal elementary dosing regimen and computer algorithm EDFAST. Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:2 Topics: Algorithms; Biological Availability; Computer Simulation; Drug Administration Schedule; Humans; Kinetics; Lidocaine; Microcomputers; Models, Biological; Pharmaceutical Preparations; Theophylline; Tissue Distribution	1987
Assessment of the Corvac blood collection tube for drug specimen processing. Therapeutic drug monitoring, 1986, Volume: 8, Issue:2 Topics: Blood Specimen Collection; Humans; Lidocaine; Pentobarbital; Pharmaceutical Preparations; Phenytoin; Quinidine; Theophylline; Time Factors	1986
Evidence for a non-adrenergic inhibitory nervous pathway in guinea-pig trachea. British journal of pharmacology, 1973, Volume: 48, Issue:2 Topics: Animals; Atropine; Cyclic AMP; Electric Stimulation; Guanethidine; Guinea Pigs; Hydroxydopamines; Imidazoles; In Vitro Techniques; Lidocaine; Methysergide; Muscle Contraction; Neural Inhibition; Propranolol; Reserpine; Tetrodotoxin; Theophylline; Trachea	1973
The effect of methylxanthines and local anesthetics on fragmented sarcoplasmic reticulum. The Journal of pharmacology and experimental therapeutics, 1969, Volume: 169, Issue:2 Topics: Adenosine Triphosphatases; Aminophylline; Anesthetics, Local; Animals; Biological Transport, Active; Caffeine; Calcium; Cell Membrane Permeability; Endoplasmic Reticulum; Hot Temperature; Lidocaine; Muscles; Procaine; Rabbits; Tetracaine; Theophylline; Veratrine; Xanthines	1969
[Antiarrhythmic effect of sviomarin in experimental and clinical glycoside poisoning]. Zeitschrift fur Kreislaufforschung, 1969, Volume: 58, Issue:6 Topics: Animals; Arrhythmias, Cardiac; Digitalis Glycosides; Diphenhydramine; Dogs; Electrocardiography; Female; Heart Failure; Histamine H1 Antagonists; Humans; Injections, Intramuscular; Injections, Intravenous; Lidocaine; Male; Ouabain; Theophylline	1969
[Therapeutic results in acute reduction of hearing]. Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde, 1969, Dec-22, Volume: 194, Issue:2 Topics: Acute Disease; Autonomic Nerve Block; Deafness; Hearing; Hearing Disorders; Humans; Lidocaine; Nicotinic Acids; Theophylline; Time Factors; Vertigo; Vitamin B Complex	1969
A potent, structurally specific stimulant action of procaine in bullfrog lung. Comparative biochemistry and physiology. C: Comparative pharmacology, 1982, Volume: 72, Issue:1 Topics: Acetylcholine; Animals; Aorta; Atropine; Dose-Response Relationship, Drug; Lidocaine; Lung; Procaine; Rana catesbeiana; Stomach; Structure-Activity Relationship; Theophylline	1982
Stability of standard curves prepared for EMIT homogeneous enzyme immunoassay kits stored at room temperature after reconstitution. Clinical chemistry, 1980, Volume: 26, Issue:5 Topics: Acecainide; Gentamicins; Humans; Lidocaine; Procainamide; Reagent Kits, Diagnostic; Reference Standards; Theophylline	1980
The involvement of the enteric nervous system in the intestinal secretion evoked by cyclic adenosine 3'5'-monophosphate. Acta physiologica Scandinavica, 1984, Volume: 120, Issue:2 Topics: Animals; Autonomic Nervous System; Blood Pressure; Bucladesine; Cats; Denervation; Female; Gastrointestinal Motility; Hexamethonium Compounds; Intestinal Mucosa; Intestines; Lidocaine; Male; Rats; Rats, Inbred Strains; Regional Blood Flow; Tetrodotoxin; Theophylline	1984
EMIT assay curve stability. Clinical chemistry, 1983, Volume: 29, Issue:9 Topics: Gentamicins; Humans; Immunoenzyme Techniques; Lidocaine; Phenytoin; Reagent Kits, Diagnostic; Theophylline	1983
Pharmacokinetics of pentobarbital, quinidine, lidocaine, and theophylline in the thermally injured rat. Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:8 Topics: Animals; Burns; Dialysis; Kinetics; Lidocaine; Male; Pentobarbital; Quinidine; Rats; Rats, Inbred Strains; Theophylline	1984
Extent of analyst bias in drug-assay results. American journal of hospital pharmacy, 1982, Volume: 39, Issue:3 Topics: Chromatography, High Pressure Liquid; Humans; Lidocaine; Pharmaceutical Preparations; Quality Control; Theophylline; Valproic Acid	1982
Enhanced rectal absorption of theophylline, lidocaine, cefmetazole, and levodopa by several adjuvants. Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:8 Topics: Adjuvants, Pharmaceutic; Animals; Cefmetazole; Cephamycins; Hydrogen-Ion Concentration; Intestinal Absorption; Levodopa; Lidocaine; Male; Rats; Rats, Inbred Strains; Rectum; Stimulation, Chemical; Theophylline	1982
[Dyspnea--what is to be done?]. Wiener medizinische Wochenschrift (1946), 1982, Apr-30, Volume: 132, Issue:8 Topics: Diazepam; Digoxin; Diuretics; Dyspnea; Emergencies; Epinephrine; Glucocorticoids; Humans; Lidocaine; Myocardial Infarction; Nitrates; Pulmonary Edema; Theophylline	1982
Enhancement of rectal absorption of drugs by adjuvants. Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:6 Topics: Absorption; Adjuvants, Pharmaceutic; Animals; Lidocaine; Male; Perfusion; Pharmaceutical Preparations; Rats; Rectum; Salicylates; Theophylline	1980
Arterial-venous plasma concentration differences of six drugs in the dog and rabbit after intravenous administration. Research communications in chemical pathology and pharmacology, 1981, Volume: 32, Issue:1 Topics: Animals; Arteries; Dogs; Furosemide; Griseofulvin; Injections, Intravenous; Kinetics; Lidocaine; Male; Pharmaceutical Preparations; Procainamide; Propranolol; Rabbits; Theophylline; Veins	1981
Dosing regimens in seriously ill patients. Journal of the Iowa Medical Society, 1980, Volume: 70, Issue:2 Topics: Adolescent; Adult; Child; Child, Preschool; Digoxin; Disease; Drug Administration Schedule; Humans; Infant; Lidocaine; Penicillin G; Procainamide; Theophylline	1980
Changes in the metabolism of three model substrates catalysed by different P450 isozymes when administered as a cocktail to the carbon tetrachloride-intoxicated rat. Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:10 Topics: Animals; Biotransformation; Caffeine; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Hydantoins; Injections, Intravenous; Isoenzymes; Lidocaine; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Theophylline	1995
Sensitization of Burkholderia cepacia to antibiotics by cationic drugs. The Journal of antimicrobial chemotherapy, 1998, Volume: 41, Issue:2 Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; Azithromycin; Burkholderia cepacia; Cations; Ceftazidime; Dibucaine; Diphenhydramine; Drug Therapy, Combination; Famotidine; Gentamicins; Lidocaine; Microbial Sensitivity Tests; Structure-Activity Relationship; Theobromine; Theophylline	1998
Role of the enteric nervous system in the fluid and electrolyte secretion of rotavirus diarrhea. Science (New York, N.Y.), 2000, Jan-21, Volume: 287, Issue:5452 Topics: Animals; Animals, Newborn; Body Water; Diarrhea; Electrolytes; Enteric Nervous System; Hexamethonium; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Lidocaine; Mecamylamine; Mice; Mice, Inbred BALB C; Nicotinic Antagonists; Patch-Clamp Techniques; Rotavirus Infections; Synaptic Transmission; Tetrodotoxin; Theophylline	2000
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes. Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:2 Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal	2005
Positive inotropic effect of Murraya koenigii (Linn.) Spreng extract on an isolated perfused frog heart. Indian journal of experimental biology, 2006, Volume: 44, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Calcium; Dose-Response Relationship, Drug; Ethanol; Heart; Imidazoles; Lidocaine; Murraya; Myocardium; Phosphodiesterase Inhibitors; Piperazines; Plant Extracts; Propranolol; Purines; Ranidae; Sildenafil Citrate; Sulfones; Theophylline; Vasodilator Agents; Verapamil	2006
Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis. Clinical pharmacokinetics, 2008, Volume: 47, Issue:11 Topics: Alfentanil; Humans; Levetiracetam; Lidocaine; Liver Cirrhosis; Models, Biological; Piracetam; Theophylline	2008
Impact of the experimental conditions on drug release from parenteral depot systems: From negligible to significant. International journal of pharmaceutics, 2012, Aug-01, Volume: 432, Issue:1-2 Topics: Dexamethasone; Drug Implants; Ibuprofen; Infusions, Parenteral; Kinetics; Lactic Acid; Lidocaine; Lipids; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prilocaine; Propranolol; Theophylline; X-Ray Diffraction	2012
Prediction of inter-individual variability on the pharmacokinetics of CYP1A2 substrates in non-smoking healthy volunteers. Drug metabolism and pharmacokinetics, 2016, Volume: 31, Issue:4 Topics: Area Under Curve; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Healthy Volunteers; Humans; Lidocaine; Monte Carlo Method; Phenacetin; Theophylline	2016
Exploratory studies in heat-assisted continuous twin-screw dry granulation: A novel alternative technique to conventional dry granulation. International journal of pharmaceutics, 2019, Jan-30, Volume: 555 Topics: Acetaminophen; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Delayed-Action Preparations; Drug Compounding; Drug Stability; Drug Storage; Excipients; Hot Temperature; Lidocaine; Tablets; Technology, Pharmaceutical; Theophylline; Transition Temperature; X-Ray Diffraction	2019