lidocaine has been researched along with tetrodotoxin in 310 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 109 (35.16) | 18.7374 |
| 1990's | 84 (27.10) | 18.2507 |
| 2000's | 80 (25.81) | 29.6817 |
| 2010's | 36 (11.61) | 24.3611 |
| 2020's | 1 (0.32) | 2.80 |
| Authors | Studies |
|---|---|
| Collier, B; Lavoie, PA; Tenenhouse, A | 1 |
| Almers, W; Cahalan, MD | 1 |
| Ritchie, JM | 3 |
| Seeman, P; Staiman, A | 1 |
| Hayashi, H | 1 |
| Haegerstam, G | 1 |
| Fleckenstein, A; Späh, F | 1 |
| El-Sherif, N; Hope, RR; Lazzara, R; Scherlag, BJ | 1 |
| Anuras, S; Arthur, C; Christensen, J | 1 |
| DeStefano, MJ; Rabinovitch, M | 1 |
| Cohen, EN; Kendig, JJ | 1 |
| Cohen, SA; Nelson, PG; Shainberg, A | 1 |
| Josephson, I; Sperelakis, N | 1 |
| Kelder, D; Ross, SB | 1 |
| Takman, BH | 1 |
| Albuquerque, EX; Brookes, N; Onur, R; Warnick, JE | 1 |
| Brady, T; Condouris, GA; Goebel, RH | 1 |
| Greer, MA; Sato, N; Wang, X | 1 |
| Narahashi, T; Roy, ML | 1 |
| Akaike, N; Munakata, M; Yamanaka, H | 1 |
| Akaike, N; Takahashi, K | 1 |
| Chen, M; Fozzard, HA; Kyle, JW; Rogart, RB; Satin, J | 1 |
| Mody, I; Otis, TS | 1 |
| Bourinet, E; Charnet, P; Nargeot, J | 1 |
| Gage, PW; Ju, YK; Saint, DA | 2 |
| Gomi, Y; Suzuki, N | 1 |
| Fändriks, L; Hamlet, A; Jönson, C | 1 |
| Brunet, PC; Gaumann, DM; Jirounek, P | 1 |
| McGivern, J; Scholfield, CN | 1 |
| Ballabeni, V; Barocelli, E; Chiavarini, M; Impicciatore, M; Morini, G; Silva, C; Vitali, T | 1 |
| Kigoshi, S; Muramatsu, I; Nishio, M; Ohmura, T | 1 |
| Dillon, K; Ezrin, AM; Krafte, DS; Volberg, WA | 1 |
| Leung, LW; Yim, CY | 1 |
| Rubin, E; Stewart, G; Thomas, AP | 1 |
| Carmeliet, E; Tytgat, J; Vereecke, J | 1 |
| Rozanski, GJ; Witt, RC | 1 |
| Abete, P; Ferrara, N; Rengo, F; Vassalle, M | 1 |
| Cheng, YZ; Liu, TF; Wang, ZM | 1 |
| Karlsson, JA; Richardson, PS; Somerville, M | 1 |
| Fakler, B; Rüdel, R; Ruppersberg, JP; Spittelmeister, W | 1 |
| Oortgiesen, M; van Kleef, RG; Vijverberg, HP | 1 |
| Kigoshi, S; Muramatsu, I; Ohmura, T; Saito, K; Shibata, S | 1 |
| Hsiung, GR; Puil, E | 1 |
| Dankó, M; Lathrop, DA; Nánási, PP; Varró, A | 1 |
| Jodal, M; Lundgren, O; Sjövall, H; Tantisira, MH | 1 |
| MacVicar, BA; Pittman, QJ; Williams, PJ | 1 |
| Agnew, WS; Emerick, MC; Rosenberg, RL; Tomiko, SA | 1 |
| Hadley, RW; Hume, JR; Lee, KS; Vassilev, PM | 1 |
| Kappagoda, T; Senaratne, MP | 1 |
| Keynes, RD | 1 |
| Abe, T; Satake, M; Yanagawa, Y | 1 |
| Morad, M; Su, MJ | 1 |
| Salata, JJ; Wasserstrom, JA | 1 |
| Josephson, IR | 1 |
| Lewis, RJ | 1 |
| Akaike, N; Ikemoto, Y; Kaneda, M; Oyama, Y | 1 |
| Bril, A; Kinnaird, AA; Man, RY | 1 |
| Chubb, MC; Crill, WE; Schwindt, PC; Stafstrom, CE | 1 |
| Aomine, M | 1 |
| Ozaki, S | 1 |
| Ishikawa, H | 1 |
| Richardson, PS; Somerville, M | 1 |
| Baranyi, A; Gruen, E; Holmes, W; Nenov, V; Strecker, GJ; Szente, MB; Woody, CD | 1 |
| Coraboeuf, E; Coulombe, A; Deroubaix, E; Escande, D | 1 |
| Eklund, S; Jodal, M; Lundgren, O | 1 |
| Maggi, CA; Manzini, S; Meli, A | 1 |
| Balázs, R; Gallo, V; Jørgensen, OS; Kingsbury, A | 1 |
| Jivegård, L; Svanvik, J; Thornell, E | 1 |
| Azuma, M; Gotoh, Y; Kanno, M; Kemmotsu, O; Nakaya, H; Ozaki, S | 1 |
| Gustafsson, LE; Samuelson, UE; Wiklund, NP | 1 |
| Brock, JA; Cunnane, TC | 1 |
| Alaranta, S; Klinge, E; Sjöstrand, NO | 1 |
| Elharrar, V | 1 |
| Brann, LR; Vermillion, DL; Wood, JD | 1 |
| Christensen, J; Percy, WH | 1 |
| Buchanan, JW; Gettes, LS; Saito, T | 1 |
| Hoffman, BF; Roden, DM | 1 |
| Anderson, KE; Edström, A | 1 |
| Bennett, A; Stockley, HL | 1 |
| Coleman, RA; Levy, GP | 1 |
| Tanz, RD | 1 |
| Andén, NE; Magnusson, T; Stock, G | 1 |
| Cooper, JR; Itokawa, Y | 1 |
| Wood, JD | 2 |
| Biber, B; Lundgren, O; Svanvik, J | 1 |
| Cutler, RW; Hammerstad, JP | 1 |
| Jacobs, A; Keatinge, WR | 1 |
| Huang, TF | 1 |
| Quastel, JH; Shankaran, R | 1 |
| Marsh, DR; Wood, JD | 1 |
| Albuquerque, EX; Narahashi, T; Seyama, I | 1 |
| Biber, B; Fara, J; Lundgren, O | 1 |
| Biber, B; Fara, J | 1 |
| Henderson, R; Ritchie, JM; Strichartz, GR | 1 |
| Okawa, H | 1 |
| Jensen, DW; Meiss, RA; Prosser, CL | 1 |
| Chau-Wong, M; Chen, SS; Seeman, P; Staiman, A | 1 |
| Ohkawa, H; Prosser, CL | 1 |
| Elliott, KA; Gottesfeld, Z | 1 |
| Morita, Y | 1 |
| Tsuchida, Y; Yonemura, D | 1 |
| Perkins, WE; Wood, JD | 1 |
| Bass, P; Hug, CC; Weisbrodt, NW; Weisenthal, LM | 1 |
| Tsuchida, Y | 1 |
| Bennett, A; Fleshler, B | 1 |
| Hille, B | 2 |
| Iven, H; Pursche, R; Zetler, G | 1 |
| Aniukhovskiĭ, EP; Beloshapko, GG; Rozenshtraukh, LV | 1 |
| Gronstad, KO; Jaffe, BM; Yeo, CJ; Zinner, MJ | 1 |
| Colatsky, TJ | 1 |
| Carmeliet, E; Saikawa, T | 1 |
| Connors, BW; Prince, DA | 1 |
| Bustamante, JO; McDonald, TF | 1 |
| Eisner, DA; Lederer, WJ; Sheu, SS | 1 |
| Cassuto, J; Eklund, S; Jodal, M; Lundgren, O | 1 |
| James, C; Lawrence, JC; Salsgiver, WJ | 1 |
| Atarashi, H; Elharrar, V; Surawicz, B | 1 |
| Hamasaki, Y; Said, SI | 1 |
| Bozkurt, A; Onur, R | 1 |
| Cassuto, J; Jodal, M; Karlström, L; Lundgren, O | 1 |
| Cassuto, J; Jodal, M; Lundgren, O; Siewert, A | 1 |
| Bowers, LM; Brenneman, DE; Habig, WH; Neale, EA; Nelson, PG | 1 |
| Boyden, PA; Cranefield, PF; Gadsby, DC; Wit, AL | 1 |
| Alperovich, G; Jalife, J; Megna, JL; Salata, JJ | 1 |
| Brunsson, I; Cassuto, J; Jodal, M; Lundgren, O; Sjöqvist, A | 1 |
| Satoh, H | 1 |
| Kodama, I; Shibata, S; Toyama, J; Yamada, K | 1 |
| Danilo, P; Rosen, MR | 1 |
| Deitmer, JW; Ellis, D | 1 |
| Danilo, P; Hordof, AJ; Malm, JR; Mary-Rabine, L; Rosen, MR | 1 |
| Covino, BG; Gissen, AJ; Gregus, J | 1 |
| Charpak, S; Llinás, R; Paré, D | 1 |
| Bollen, AW; Ciriales, R; Drasner, K; Sakura, S | 1 |
| Cunha-Melo, JR; Da Luz, MM; Freire-Maia, L; Mendonça, M | 1 |
| Chang, W; Strahlendorf, HK; Strahlendorf, JC | 1 |
| De Clerck, F; Lu, HR | 1 |
| Jaffe, RA; Rowe, MA | 1 |
| Brown, NA; Kemp, JA; Seabrook, GR | 1 |
| Taylor, CP; Weber, ML | 1 |
| Chen, NH; Reith, ME | 1 |
| Andresen, MC; Brodwick, M; Yang, M | 1 |
| Bosnjak, ZJ; Hogan, QH; Kampine, JP; Stadnicka, A; Stekiel, TA | 1 |
| Kupersmith, J; Li, ZY; Maldonado, C; Wang, YH | 1 |
| Barker, JL; Schaffner, AE; Vautrin, J | 1 |
| Haigney, MC; Lakatta, EG; Silverman, HS; Stern, MD | 1 |
| Benaim, G; Giuliani, S; Lazzeri, M; Lecci, A; Maggi, CA; Turini, D | 1 |
| Barchi, RL; Davison, K; Dugrenier, N; Estep, K; Ezrin, AM; Josef, K; Kallen, RG; Krafte, DS; Silver, PJ | 1 |
| Butterworth, J; Cole, L; Marlow, G | 1 |
| Bass, P; See, NA | 1 |
| Hubel, KA; Russ, L | 1 |
| Isaac, JT; Wheal, HV | 1 |
| Caeser, M; Kemp, JA; Seabrook, GR | 1 |
| Browning, M; Dunwiddie, TV; Smith, DA | 1 |
| De Clerck, F; Lu, HR; Remeysen, P | 1 |
| Bloomfield, SA | 1 |
| Weekley, LB | 1 |
| Feinmark, SJ; Guo, SD; Hoffman, BF | 1 |
| Motahed-Larijani, Z; Motamedi, F; Rashidy-Pour, A | 1 |
| Gibson, IC; Logan, SD; Nolan, MF; Pickering, AE; Spanswick, D | 1 |
| Fleidervish, IA; Gutnick, MJ | 1 |
| Kobayashi, J; Ohta, M; Terada, Y | 1 |
| Albat, B; Nargeot, J; Quignard, JF; Richard, S; Ryckwaert, F | 1 |
| Cummins, TR; Waxman, SG | 1 |
| Borosky, S; Marcoux, FW; Probert, AW; Taylor, CP | 1 |
| Stamford, JA; Toner, CC | 1 |
| Ito, KI; Kato, H; Miura, M; Miyakawa, H; Yoshioka, M | 1 |
| Börjesson, L; Delbro, DS; Nordgren, S | 2 |
| Matsuki, N; Nakagami, Y; Saito, H | 1 |
| Hochman, S; MacLean, JN; Schmidt, BJ | 1 |
| Hempelmann, G; Kuboyama, N; Scholz, A; Vogel, W | 1 |
| Bencsics, A; Nakai, T; Sato, T; Uchihashi, Y; Umeda, E; Vizi, ES | 1 |
| Gage, PW; Hammarstrom, AK | 3 |
| Belmonte, C; Brock, JA; McLachlan, EM | 1 |
| Kim, U; McCormick, DA | 1 |
| Lilley, SJ; Robbins, J | 1 |
| Raymond, SA; Strassman, AM | 1 |
| Grampp, W; Skogvall, S | 1 |
| Llinás, RR; Moreira, JE; Pozzo-Miller, LD | 1 |
| Mann-Metzer, P; Yarom, Y | 1 |
| Doggrell, SA; Henderson, CJ; Nand, V | 1 |
| Hagihara, A; Hashimoto, K; Sugiyama, A | 1 |
| Amir, R; Devor, M; Michaelis, M | 1 |
| Kordasti, S; Lundgren, O; Peregrin, AT; Persson, K; Svensson, L; Uhnoo, I | 1 |
| Andrzejewski, M; Ballantyne, D; Mückenhoff, K; Oyamada, Y; Scheid, P | 1 |
| Itoh, Z; Suzuki, H; Tohara, K; Uchida, Y | 1 |
| Fozzard, HA; Glaaser, IW; Sunami, A | 2 |
| Ambrogi Lorenzini, C; Baldi, E; Bucherelli, C; Tassoni, G | 1 |
| Bräu, ME; Hempelmann, G; Olschewski, A; Safronov, BV; Vogel, W | 1 |
| Brumberg, JC; McCormick, DA; Nowak, LG | 1 |
| Higo, A; Katsura, M; Mohri, Y; Ohkuma, S; Shuto, K; Takesue, M; Tarumi, C; Tsujimura, A | 1 |
| Fuller, I; Hong, A; Wood, MA | 1 |
| Al-Noori, S; Swann, JW | 1 |
| Scholz, A; Vogel, W | 1 |
| Amitzur, G; Eldar, M; Kaplinsky, E; Kraft, P; Lev-Ran, V; Mueller, M; Novikov, I; Schoels, W; Visokovsky, A | 1 |
| Bräu, ME; Dreimann, M; Hempelmann, G; Olschewski, A; Vogel, W | 1 |
| Grolleau, F; Lapied, B; Sattelle, DB | 1 |
| Saino, T; Shinohe, Y | 1 |
| Boehnke, SE; Rasmusson, DD | 1 |
| Chung, JM; Chung, K; Liu, X; Zhou, JL | 1 |
| Acosta, S; Miles, R; Strahlendorf, HK; Strahlendorf, JC | 1 |
| Belmonte, C; Brock, JA; Pianova, S | 1 |
| Akamine, T; Asahara, T; Asahi, M; Itoh, K; Kitagawa, H; Kumazawa, Y; Lin, M; Nishimura, Y; Saitoh, K; Shibuya, H; Yamamoto, T | 1 |
| Berman, N; Dunn, RJ; Maler, L | 1 |
| Barrionuevo, G; González-Burgos, G | 1 |
| Gold, MS; Thut, PD | 1 |
| Chambers, G; Cottrell, JE; Kass, IS; Newman, RB; Raley-Susman, KM; Wang, J | 1 |
| Farrugia, G; Gibbons, S; Holm, AN; Miller, SM; Ou, Y; Rae, JL; Rich, A; Sarr, MG; Strege, P; Szurszewski, JH | 1 |
| di, A; Fontana, MD; Heluany, NF; Leite, GB; Vital, BO | 1 |
| Costa, SK; Docherty, RJ; Farrag, KJ | 1 |
| Paton, DM | 1 |
| Lam, TT; Oliva, AA; Swann, JW | 1 |
| Persaud, N; Strichartz, GR | 1 |
| McMahon, CM; Patuzzi, RB | 1 |
| Helyes, Z; Jakab, B; Németh, J; Oroszi, G; Pintér, E; Szilvássy, Z; Szolcsányi, J | 1 |
| Rota, M; Vassalle, M | 1 |
| Edman, KA; Mutungi, G; Ranatunga, KW | 1 |
| HANSON, FE; WOLBARSHT, ML | 1 |
| Bräu, ME; Hempelmann, G; Kox, WJ; Poyraz, D; Puhlmann, B; Scholz, AM; Spies, CD; Wotka, F | 1 |
| Acharfi, S; Benammar, N; Chahine, M; Delacrétaz, E; Fressart, V; Guicheney, P; Keller, DI; Pfammatter, JP; Rotter, M | 1 |
| Andrade, R; Béïque, JC; Chapin-Penick, EM; Mladenovic, L | 1 |
| Dahmani, S; Desmonts, JM; Mantz, J; Reynaud, C; Rouelle, D; Tesnière, A | 1 |
| Curti, S; Pereda, AE | 1 |
| Hamakawa, T; Ibusuki, S; Kasaba, T; Onizuka, S; Takasaki, M | 1 |
| Bozkurt, TE; Sahin-Erdemli, I | 1 |
| Dohi, S; Iida, H; Oda, A; Osawa, Y; Tanahashi, S | 1 |
| Komatsu, Y; Kurotani, T; Liu, HN; Ren, M; Yamada, K; Yoshimura, Y | 1 |
| Acharfi, S; Chahine, M; Chang, CC; Chiang, FT; Sung, TC; Wang, JK; Wu, MH | 1 |
| Ichinose, T; Lukasiewicz, PD; Shields, CR | 1 |
| Cummins, TR; Dib-Hajj, SD; Herzog, RI; Leffler, A; Waxman, SG | 1 |
| Swant, J; Thompson, AM; Wagner, JJ | 1 |
| Kitamura, N; Komagiri, Y; Konno, A; Kuwahara, T | 1 |
| Görtz, P; Hartung, HP; Kieseier, BC; Otto, F; Siebler, M | 1 |
| Weiser, T | 1 |
| Amagasu, SM; Axt, S; Chang, R; Church, T; Gee, C; Hembrador, J; Jacobsen, JR; Jenkins, T; Kaufman, E; Mai, N; Smith, JA; Vickery, RG | 1 |
| Le Grand, B; Létienne, R; Vié, B | 1 |
| Binshtok, AM; Fleidervish, IA; Gutnick, MJ; Sprengel, R | 1 |
| Fleischer, W; Klusmann, A; Mayatepek, E; Siebler, M; Waldhaus, A | 1 |
| Cassuto, J; Jodal, M; Lundgren, O; Tuttle, R | 1 |
| Nylander, O; Pihl, L | 1 |
| Bánfalvi, G; Kiss-Tóth, E; Petkó, M; Roszer, T; Szentmiklósi, AJ | 1 |
| Terman, GW; Thomson, LM; Zeng, J | 1 |
| Cassel, JC; Certa, U; Cosquer, B; Klur, S; Lopez, J; Muller, C; Pereira de Vasconcelos, A | 1 |
| Boddy, G; Daniel, EE; Galante, G; Willis, A | 1 |
| Docherty, RJ; Farrag, KJ | 1 |
| Leffler, A; Mohapatra, DP; Nau, C; Reiprich, A | 1 |
| Bocchi, L; Du, F; Vassalle, M | 1 |
| DeWeese, MR; Zador, AM | 1 |
| Bae, YC; Hirai, T; Kang, Y; Maeda, Y; Saito, M; Sato, H; Toyoda, H | 1 |
| Gross, GW; Parviz, M | 1 |
| Dohi, S; Iida, H; Oda, A; Osawa, Y; Tanahashi, S; Uchida, M | 1 |
| Chahine, M; Chatelier, A; O'leary, ME; Zhao, J; Ziane, R | 1 |
| Dohi, S; Iida, H; Oda, A; Osawa, Y; Tanahashi, S; Yamaguchi, S | 1 |
| Feenstra, MG; Joosten, RN; Mulder, AB; Pennartz, CM; van der Blom, R; van der Plasse, G; van Duuren, E | 1 |
| Dong, H; Fan, YH; Hu, SJ; Wang, WT; Wang, YY | 1 |
| Grafe, P; Hilmer, VB; Lang, PM | 1 |
| Bornstein, JC; Larsson, MH; Lindström, E; Sapnara, M; Sjövall, H; Svensson, DJ; Thomas, EA | 1 |
| Carr, RW; De Col, R; Messlinger, K | 1 |
| Huang, CJ; Huang, YH; Lee, PY; Tsai, PS | 1 |
| Chartier, D; Leblanc, N; Nattel, S; Ruben, PC; Sun, H; Varela, D; Zamponi, GW | 1 |
| Bruhova, I; Tikhonov, DB; Zhorov, BS | 1 |
| Fox, K; Hardingham, NR; Phillips, KG | 1 |
| Kim, MS; Medvedeva, YV; Schnizler, K; Usachev, YM | 1 |
| Cohen, D; Segal, M | 1 |
| Aguirre, MJ; Cimadevilla, JM; Fernández, R; López, F; Nieto, L | 1 |
| Chen, CL; Chen, JJ; Chiang, RP; Huang, CT; Lin, LH; Lue, JH; Tsai, YJ | 1 |
| Ehnert, C; Kistner, K; Leffler, A; Reeh, PW; Zimmermann, K | 1 |
| Cheng, J; Fox, LE; Liu, Q; Ma, K; Pappas, GD; Qu, T; Shen, J; Shi, G | 1 |
| Aguilar, J; Alonso-Calviño, E; Foffani, G; Humanes-Valera, D; Moxon, KA; Oliviero, A; Yague, JG | 1 |
| Cummins, TR; Jarecki, BW; Sheets, PL | 1 |
| Carneiro, RF; Costa, PP; de Oliveira Toyama, D; de Oliveira, SC; de Souza, AJ; Dos Santos Diz Filho, EB; Fonteles, MC; Gomes, VM; Nascimento, NR; Santos, CF; Toyama, MH; Zara, FJ | 1 |
| Adachi, M; Bal, M; Kavalali, ET; Monteggia, LM; Sara, Y | 1 |
| Kanai, T; Maruta, T; Nemoto, T; Satoh, S; Tsuneyoshi, I; Wada, A; Yanagita, T | 1 |
| Bruckner-Tuderman, L; Chiang, LY; Duarte, N; Hu, J; Koch, M; Lewin, GR; Oliveira, BE; Poole, K; Sierra, YA | 1 |
| Fukuda, K; Kondo, M; Kumagai, K; Miura, M; Nakano, M; Shimokawa, H; Shirato, K; Wakayama, Y; Watanabe, J; Yagi, T | 1 |
| Berrebi, AS; Felix, RA; Fridberger, A; Leijon, S; Magnusson, AK | 1 |
| Hanse, E; Riebe, I | 1 |
| Frank, G; Kistner, K; Koppert, W; Leffler, A; Nau, C; Niedermirtl, F; Reeh, PW | 1 |
| Beck-Schimmer, B; Borgeat, A; Liu, G; Minshall, RD; Piegeler, T; Place, AT; Schwartz, DE; Votta-Velis, EG | 1 |
| Bornstein, JC; Hao, MM; Lomax, AE; McKeown, SJ; Reid, CA; Young, HM | 1 |
| Hernan, A; Holmes, GL; Isaev, D; Isaeva, E | 1 |
| Hescheler, J; Kuzmenkin, A; Mohammad, FI; Nguemo, F; Pfannkuche, K; Reppel, M; Sheng, X | 1 |
| Bamford, IJ; Bamford, NS; Lemos, JC; Lewis, JS; Nitulescu, I; Phillips, PE; Posielski, NM; Storey, GP; Wang, W | 1 |
| Aman, TK; Bant, JS; Raman, IM | 1 |
| Butler, E; Garcia-Bereguiain, MA; Gonzalez-Islas, C; Hill, AW; Lindsly, C; Wenner, P | 1 |
| Grill, WM; Kent, AR | 1 |
| Kayano, T; Kitamura, N; Komagiri, Y; Kuwahara, T; Moriya, T; Shibuya, I; Toescu, EC | 1 |
| Golovko, VA; Lebedeva, EA | 1 |
| Cummins, TR; Knopp, KL; Krajewski, JL; McDermott, JS; Nisenbaum, ES; Piekarz, AD; Priest, BT; Tan, ZY | 1 |
| Feige, K; Geburek, F; Hoppe, S; Huber, K; Tappenbeck, K | 1 |
| Bányász, T; Hegyi, B; Horváth, B; Kistamás, K; Magyar, J; Nánási, PP; Ruzsnavszky, F; Szentandrássy, N; Váczi, K; Varró, A | 1 |
| Chambers, JP; Hulls, CM; Janssen, PW; King, QM; Lentle, RG; Reynolds, GW | 1 |
| Ahmed, Z; Wieraszko, A | 1 |
| Alvarez, P; Green, PG; Levine, JD | 1 |
| Kharatmal, SB; Sharma, SS; Singh, JN | 1 |
| Lewis, RJ; Malsch, P; Reeh, PW; Sattler, S; Touska, F; Zimmermann, K | 1 |
| Nesterov, AV; Revenko, SV; Tarakanov, IA; Tikhomirova, LN | 1 |
| Cheng, SX; Jiang, L; McIntyre, ME; Petrova, E; Tang, L | 1 |
| Hamaguchi, S; Hiiro, H; Irie, M; Namekata, I; Tanaka, H | 1 |
| Bai, K; Chen, Y; He, J; Hong, B; Huang, W; Le, Q | 1 |
| Sijm, DTHM; Tukker, AM; van Kleef, RGDM; Vrolijk, MF; Westerink, RHS | 1 |
| Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA | 1 |
2 review(s) available for lidocaine and tetrodotoxin
| Article | Year |
|---|---|
A pharmacological approach to the structure of sodium channels in myelinated axons.
Topics: Aconitine; Action Potentials; Anesthetics, Local; Animals; Anura; Batrachotoxins; Benzocaine; Binding Sites; Chemical Phenomena; Chemistry; Decapodiformes; Ion Channels; Lidocaine; Molecular Conformation; Nerve Fibers, Myelinated; Ranvier's Nodes; Saxitoxin; Tetrodotoxin; Veratridine | 1979 |
Ion channels as therapeutic targets: a drug discovery perspective.
Topics: Drug Discovery; Humans; Ion Channels; Models, Molecular; Phylogeny | 2013 |
1 trial(s) available for lidocaine and tetrodotoxin
| Article | Year |
|---|---|
Differential contribution of sodium channel subtypes to action potential generation in unmyelinated human C-type nerve fibers.
Topics: Action Potentials; Anesthetics, Local; Anti-Arrhythmia Agents; Electric Stimulation; Electrophysiology; Humans; In Vitro Techniques; Lidocaine; Membrane Potentials; Mexiletine; Nerve Fibers, Unmyelinated; Sensory Thresholds; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2007 |
307 other study(ies) available for lidocaine and tetrodotoxin
| Article | Year |
|---|---|
Role of skeletal muscle activity in the control of muscle acetylcholine sensitivity.
Topics: Acetylcholine; Animals; Axonal Transport; Bungarotoxins; Dose-Response Relationship, Drug; Female; Lidocaine; Muscle Contraction; Muscles; Neural Conduction; Rats; Receptors, Cholinergic; Sciatic Nerve; Tetrodotoxin | 1977 |
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin.
Topics: Animals; Axons; Decapodiformes; Ion Channels; Lidocaine; Sodium; Tetrodotoxin | 1979 |
Binding of tetrodotoxin and saxitoxin to sodium channels.
Topics: Animals; Diaphragm; Electrophysiology; Fishes; Hydrogen-Ion Concentration; In Vitro Techniques; Lidocaine; Models, Neurological; Muscle Denervation; Nephropidae; Neural Conduction; Neurons; Olfactory Nerve; Ouabain; Rabbits; Saxitoxin; Sodium; Surface Properties; Tetrodotoxin; Thallium; Vagus Nerve; Veratrine | 1975 |
Mechanism of action of local anaesthetic agents and biotoxins.
Topics: Acetylcholine; Action Potentials; Anesthetics, Local; Animals; Benzocaine; Binding Sites; Binding, Competitive; Calcium; Cell Membrane; Fishes; Humans; Hydrogen-Ion Concentration; Lidocaine; Membrane Potentials; Neural Conduction; Potassium; Procaine; Rabbits; Saxitoxin; Sodium; Structure-Activity Relationship; Surface Properties; Tetrodotoxin; Toxins, Biological | 1975 |
Conduction-blocking concentrations of anesthetics increase with nerve axon diameter: studies with alcohol, lidocaine and tetrodotoxin on single myelinated fibers.
Topics: Action Potentials; Anesthetics; Animals; Axons; Benzyl Alcohols; Benzyl Compounds; Depression, Chemical; In Vitro Techniques; Lidocaine; Nerve Fibers, Myelinated; Neural Conduction; Rana catesbeiana; Sciatic Nerve; Tetrodotoxin | 1977 |
Rapid penetration of potassium and other salts into the frog tongue papilla.
Topics: Action Potentials; Animals; Anura; Ethanol; Glossopharyngeal Nerve; In Vitro Techniques; Lidocaine; Permeability; Potassium; Rana catesbeiana; Tetrodotoxin; Tongue | 1978 |
Effect of i.v. administration of lignocaine and tetrodotoxin on sensory units in the tooth of the cat.
Topics: Action Potentials; Animals; Cats; Dental Pulp; Injections, Intra-Arterial; Injections, Intravenous; Lidocaine; Sensory Receptor Cells; Tetrodotoxin | 1979 |
Evidence of a new, preferentially Mg-carrying, transport system besides the fast Na and the slow Ca channels in the excited myocardial sarcolemma membrane.
Topics: Action Potentials; Animals; Biological Transport; Calcium; Catecholamines; Guinea Pigs; In Vitro Techniques; Ion Channels; Lidocaine; Magnesium; Myocardium; Sarcolemma; Sodium; Tetrodotoxin | 1979 |
Effects of lidocaine on hypoxic and ischemic cardiac cells.
Topics: Action Potentials; Animals; Coronary Disease; Dogs; Electric Stimulation; Endocardium; Heart Conduction System; Hypoxia; In Vitro Techniques; Lidocaine; Membrane Potentials; Purkinje Fibers; Tetrodotoxin | 1978 |
Influence of intrinsic nerves on electromyogram of cat colon in vitro.
Topics: Action Potentials; Animals; Autonomic Nervous System; Cats; Colon; Electromyography; Female; In Vitro Techniques; Lidocaine; Male; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Reserpine; Sympatholytics; Sympathomimetics; Tetrodotoxin | 1978 |
Cell shape changes induced by cationic anesthetics.
Topics: Anesthetics, Local; Animals; Benzocaine; Cell Adhesion; Cell Fusion; Cell Membrane; Cell Movement; Chlorpromazine; Culture Media; Dibucaine; Edetic Acid; Egtazic Acid; Female; HEPES; Lidocaine; Macrophages; Mice; Prilocaine; Pseudopodia; Structure-Activity Relationship; Tetracaine; Tetrodotoxin; Tromethamine | 1976 |
Pressure antagonism to nerve conduction block by anesthetic agents.
Topics: Anesthetics; Anesthetics, Local; Animals; Atmospheric Pressure; Benzocaine; Cell Membrane; Halothane; Lidocaine; Male; Methoxyflurane; Neural Conduction; Procaine; Rats; Sympathetic Nervous System; Tetrodotoxin | 1977 |
Induction of acetylcholine receptors in muscle cultures.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Bungarotoxins; Chick Embryo; Creatine Kinase; Culture Techniques; Electric Stimulation; Gallopamil; Lidocaine; Mice; Muscle Contraction; Muscle Proteins; Muscles; Rats; Receptors, Cholinergic; RNA; Tetrodotoxin; Tubercidin | 1976 |
Local anesthetic blockade of Ca2+ -mediated action potentials in cardiac muscle.
Topics: Action Potentials; Anesthetics, Local; Animals; Calcium; Cells, Cultured; Chick Embryo; Cocaine; Heart; In Vitro Techniques; Lidocaine; Phenytoin; Procaine; Tetrodotoxin | 1976 |
Effect of veratridine on the fluxes of 3H-noradrenaline and 3h-bretylium in the rat vas deferens in vitro.
Topics: Aminobenzoates; Anesthetics, Local; Animals; Bretylium Compounds; Calcium; Desipramine; In Vitro Techniques; Lidocaine; Male; Muscle, Smooth; Norepinephrine; Rats; Reserpine; Tetrodotoxin; Vas Deferens; Veratridine; Veratrine | 1976 |
The chemistry of local anaesthetic agents: classification of blocking agents.
Topics: Anesthetics, Local; Benzocaine; Benzyl Compounds; Binding Sites; Binding, Competitive; Cell Membrane; Lidocaine; Models, Molecular; Neural Conduction; Neurilemma; Phenobarbital; Phenols; Saxitoxin; Sodium; Structure-Activity Relationship; Succinimides; Tetrodotoxin | 1975 |
Kinetics of interaction of batrachotoxin and tetrodotoxin on rat diaphragm muscle.
Topics: Animals; Drug Interactions; In Vitro Techniques; Kinetics; Lidocaine; Male; Membrane Potentials; Motor Endplate; Muscles; Procaine; Rats; Tetrodotoxin; Toxins, Biological | 1976 |
Computer simulation of local anesthetic effects using a mathematical model of myelinated nerve.
Topics: Anesthetics, Local; Axons; Computers; Lidocaine; Models, Biological; Myelin Sheath; Neural Conduction; Ranvier's Nodes; Sodium; Stimulation, Chemical; Tetrodotoxin; Time Factors | 1976 |
Lidocaine inhibits prolactin secretion in GH4C1 cells by blocking calcium influx.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenoma; Animals; Calcium; Colforsin; Lidocaine; Pituitary Neoplasms; Potassium; Procaine; Prolactin; Rats; Tetradecanoylphorbol Acetate; Tetrodotoxin; Tumor Cells, Cultured | 1992 |
Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons.
Topics: Animals; Cations, Divalent; Dose-Response Relationship, Drug; Drug Resistance; Electrophysiology; Ganglia, Spinal; Homeostasis; Kinetics; Lidocaine; Neurons; Rats; Saxitoxin; Sodium Channels; Tetrodotoxin | 1992 |
Novel Ca2+ currents in mammalian CNS neurons.
Topics: Animals; Calcium Channels; Central Nervous System; Hippocampus; In Vitro Techniques; Kinetics; Lidocaine; Membrane Potentials; Neurons; Rats; Rats, Inbred Strains; Scorpion Venoms; Tetrodotoxin | 1992 |
Tetrodotoxin-sensitive calcium-conducting channels in the rat hippocampal CA1 region.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Hippocampus; Lidocaine; Neurons; Rats; Sodium; Tetrodotoxin | 1992 |
The cloned cardiac Na channel alpha-subunit expressed in Xenopus oocytes show gating and blocking properties of native channels.
Topics: Animals; Cloning, Molecular; Female; Gene Expression; Heart; Ion Channel Gating; Lidocaine; Membrane Potentials; Oocytes; Rats; Sodium Channels; Tetrodotoxin; Xenopus laevis | 1992 |
Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Anesthetics, Local; Animals; Calcium Channels; Evoked Potentials; Flumazenil; Hippocampus; Kinetics; Lidocaine; Mathematics; Meglumine; Membrane Potentials; Midazolam; Models, Neurological; Neurons; Pentobarbital; Probability; Quinoxalines; Rats; Rats, Wistar; Receptors, GABA-A; Synapses; Tetrodotoxin | 1992 |
Electrophysiological characterization of a TTX-sensitive sodium current in native Xenopus oocytes.
Topics: Animals; Electrophysiology; Female; Kinetics; Lidocaine; Membrane Potentials; Oocytes; Sodium; Sodium Channels; Tetrodotoxin; Time Factors; Xenopus laevis | 1992 |
Effects of lignocaine and quinidine on the persistent sodium current in rat ventricular myocytes.
Topics: Action Potentials; Animals; Electrophysiology; Heart; Heart Ventricles; In Vitro Techniques; Lidocaine; Myocardium; Potassium; Quinidine; Rats; Sodium; Tetrodotoxin | 1992 |
Evidence that stretch receptors for peristalsis are located in the mucosal layer of the guinea pig ileum.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Lidocaine; Male; Mechanoreceptors; Morphine; Muscle Contraction; Muscle, Smooth; Nicotine; Peristalsis; Tetrodotoxin | 1992 |
The mediation of increased duodenal alkaline secretion in response to 10 mM HCl in the anaesthetized rat. Support for the involvement of capsaicin-sensitive nerve elements.
Topics: Animals; Bicarbonates; Capsaicin; Dinoprostone; Duodenum; Hydrochloric Acid; Intestinal Mucosa; Lidocaine; Male; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Vagotomy; Vagus Nerve | 1992 |
Clonidine enhances the effects of lidocaine on C-fiber action potential.
Topics: Action Potentials; Animals; Clonidine; Drug Interactions; Lidocaine; Membrane Potentials; Nerve Fibers; Rabbits; Tetrodotoxin | 1992 |
Phorbol ester and lignocaine or pentobarbitone interactions at presynaptic axons.
Topics: Animals; Axons; Drug Interactions; Electrodes; In Vitro Techniques; Lidocaine; Pentobarbital; Phorbol 12,13-Dibutyrate; Rats; Synaptosomes; Tetrodotoxin | 1992 |
Anomalous responses to histamine stimulation of guinea-pig oesophageal muscularis mucosae.
Topics: Animals; Atropine; Drug Tolerance; Esophagus; Guinea Pigs; Histamine; Lidocaine; Methysergide; Mucous Membrane; Muscle Contraction; Physostigmine; Pyrilamine; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Tetrodotoxin | 1991 |
Supersensitivity to tetrodotoxin and lignocaine of sea anemone toxin II-treated sodium channel in guinea-pig ventricular muscle.
Topics: Action Potentials; Animals; Cardiotonic Agents; Cnidarian Venoms; Drug Interactions; Guinea Pigs; Heart; Heart Ventricles; Lidocaine; Male; Membrane Potentials; Sodium Channels; Tetrodotoxin | 1991 |
Expression of cardiac Na channels with appropriate physiological and pharmacological properties in Xenopus oocytes.
Topics: Animals; Brain Chemistry; Electric Conductivity; Electrophysiology; Female; Gene Expression; Guinea Pigs; Humans; Lidocaine; Myocardium; Oocytes; Piperazines; Rats; RNA; Sodium Channels; Tetrodotoxin; Transfection; Xenopus laevis | 1991 |
Intrinsic membrane potential oscillations in hippocampal neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Barium; Cadmium; Calcium; Choline; Evoked Potentials; Hippocampus; In Vitro Techniques; Interneurons; Ion Channels; Kinetics; Lidocaine; Male; Membrane Potentials; Neurons; Neurotoxins; Pyramidal Tracts; Rats; Rats, Inbred Strains; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1991 |
Inhibition by cocaine of excitation-contraction coupling in isolated cardiomyocytes.
Topics: Animals; Calcium; Cell Separation; Cocaine; Dose-Response Relationship, Drug; Electric Conductivity; Heart; Lidocaine; Membrane Potentials; Myocardial Contraction; Myocardium; Nitrendipine; Potassium; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum; Sodium Channels; Sympathetic Nervous System; Tetrodotoxin; Verapamil | 1991 |
A combined study of sodium current and T-type calcium current in isolated cardiac cells.
Topics: Adenosine; Amiloride; Animals; Calcium Channels; Flunarizine; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Kinetics; Lidocaine; Myocardium; Perfusion; Rats; Sodium Channels; Tetrodotoxin | 1990 |
Early afterdepolarizations and triggered activity in rabbit cardiac Purkinje fibers recovering from ischemic-like conditions. Role of acidosis.
Topics: Acidosis, Lactic; Animals; Cell Hypoxia; Lidocaine; Membrane Potentials; Myocardial Reperfusion Injury; Purkinje Fibers; Quinidine; Rabbits; Ryanodine; Tetrodotoxin | 1991 |
Mechanisms of lidocaine actions on normal and abnormal rhythms in canine cardiac tissues in vivo and in vitro.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Calcium; Dogs; Electric Stimulation; Electrocardiography; Female; Heart; In Vitro Techniques; Lidocaine; Male; Myocardium; Neurons; Propranolol; Purkinje Fibers; Sodium; Strophanthidin; Tetrodotoxin; Vagus Nerve | 1991 |
Early afterdepolarization induced by ryanodine in atrial fibers of mouse heart.
Topics: Action Potentials; Animals; Female; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Male; Mice; Nifedipine; Ryanodine; Tetrodotoxin | 1990 |
The effects of local anaesthetic agents upon mucus secretion in the feline trachea in vivo.
Topics: Animals; Atropine; Cats; Drug Interactions; Electric Stimulation; Histamine; Lidocaine; Mucus; Pilocarpine; Tetrodotoxin; Trachea | 1990 |
Inactivation of human sodium channels and the effect of tocainide.
Topics: Cerebellar Neoplasms; Humans; Lidocaine; Medulloblastoma; Models, Biological; Sodium Channels; Tetrodotoxin; Tocainide; Tumor Cells, Cultured | 1990 |
Block of deltamethrin-modified sodium current in cultured mouse neuroblastoma cells: local anesthetics as potential antidotes.
Topics: Anesthetics, Local; Animals; Cell Line; Electric Conductivity; Insecticides; Kinetics; Lidocaine; Membrane Potentials; Mice; Neuroblastoma; Nitriles; Pyrethrins; Sodium Channels; Tetrodotoxin; Tumor Cells, Cultured | 1990 |
Supersensitivity to tetrodotoxin and lidocaine of anthopleurin-A-treated Na+ channels in crayfish giant axon.
Topics: Action Potentials; Animals; Astacoidea; Axons; Intercellular Signaling Peptides and Proteins; Lidocaine; Peptides; Sodium Channels; Tetrodotoxin | 1990 |
Ionic dependencies of tetrodotoxin-resistant action potentials in trigeminal root ganglion neurons.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Cisplatin; Doxorubicin; Electrodes; Guinea Pigs; In Vitro Techniques; Lidocaine; Neurons; Potassium Channels; Sodium; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Trigeminal Ganglion | 1990 |
Use-dependent action of antiarrhythmic drugs in frog skeletal muscle and canine cardiac Purkinje fiber.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; In Vitro Techniques; Kinetics; Lidocaine; Microelectrodes; Muscle Contraction; Muscles; Purkinje Fibers; Quinidine; Rana esculenta; Tetrodotoxin; Verapamil | 1990 |
Intestinal fluid transport in the small intestine of normotensive and spontaneously hypertensive rats: the importance of enteric nerves, chloride and bicarbonate secretion.
Topics: Animals; Atropine; Bicarbonates; Biological Transport, Active; Chlorides; Diuretics; Electrophysiology; Hexamethonium Compounds; Hydrogen-Ion Concentration; Intestinal Secretions; Jejunum; Lidocaine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrodotoxin | 1990 |
Electrophysiological properties of neuroendocrine cells of the intact rat pars intermedia: multiple calcium currents.
Topics: Action Potentials; Animals; Calcium; Electrophysiology; Lidocaine; Male; Neurosecretory Systems; Pituitary Gland; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1990 |
Fluorescence assay for neurotoxin-modulated ion transport by the reconstituted voltage-activated sodium channel isolated from eel electric organ.
Topics: Animals; Batrachotoxins; Carrier Proteins; Electric Organ; Electrophorus; Ion Channels; Lidocaine; Liposomes; Mathematics; Models, Neurological; Naphthalenes; Neurotoxins; Sodium; Sodium Channels; Spectrometry, Fluorescence; Tellurium; Tetrodotoxin; Veratridine | 1986 |
Voltage-dependent action of tetrodotoxin in mammalian cardiac myocytes.
Topics: Animals; Calcium; Electrophysiology; Extracellular Space; Female; Guinea Pigs; Heart; Homeostasis; Ion Channels; Lidocaine; Male; Myocardium; Osmolar Concentration; Tetrodotoxin | 1986 |
Tetrodotoxin-resistant relaxation to transmural nerve stimulation in canine saphenous veins: a possible neural origin.
Topics: Animals; Ascorbic Acid; Catalase; Dogs; Electric Stimulation; In Vitro Techniques; Ion Channels; Isoproterenol; Lidocaine; Muscle Relaxation; Muscle, Smooth, Vascular; Saphenous Vein; Superoxide Dismutase; Tetrodotoxin | 1986 |
Properties of the sodium gating current in the squid giant axon.
Topics: Anesthetics, Local; Animals; Axons; Benzocaine; Ion Channels; Lidocaine; Membrane Potentials; Neural Conduction; Sodium; Tetrodotoxin | 1986 |
Mu-conotoxins share a common binding site with tetrodotoxin/saxitoxin on eel electroplax Na channels.
Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Conotoxins; Electric Organ; Electrophorus; Ion Channels; Kinetics; Lidocaine; Mollusk Venoms; Saxitoxin; Sodium; Tetrodotoxin; Veratridine | 1987 |
Effects of quinidine and lidocaine on action potential and membrane currents of frog ventricles.
Topics: Action Potentials; Animals; Heart; Heart Ventricles; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Nickel; Quinidine; Rana pipiens; Strontium; Tetrodotoxin; Ventricular Function | 1987 |
Basis for tetrodotoxin and lidocaine effects on action potentials in dog ventricular myocytes.
Topics: Action Potentials; Animals; Dogs; Drug Interactions; Heart; Heart Ventricles; In Vitro Techniques; Ion Channels; Kinetics; Lidocaine; Microelectrodes; Sodium; Tetrodotoxin; Ventricular Function | 1988 |
Lidocaine blocks Na, Ca and K currents of chick ventricular myocytes.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Chick Embryo; Heart Ventricles; Ion Channels; Lidocaine; Potassium; Sodium; Tetrodotoxin; Ventricular Function | 1988 |
Negative inotropic and arrhythmic effects of high doses of ciguatoxin on guinea-pig atria and papillary muscles.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Cardiac Complexes, Premature; Ciguatoxins; Depression, Chemical; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Lidocaine; Male; Marine Toxins; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Sodium Channels; Tetrodotoxin | 1988 |
Blockade of the voltage-dependent sodium current in isolated rat hippocampal neurons by tetrodotoxin and lidocaine.
Topics: Animals; Hippocampus; In Vitro Techniques; Lidocaine; Membrane Potentials; Rats; Sodium Channels; Tetrodotoxin | 1989 |
Comparison of the sodium currents in normal Purkinje fibres and Purkinje fibres surviving infarction--a pharmacological study.
Topics: Action Potentials; Animals; Dogs; Female; Heart Conduction System; In Vitro Techniques; Lidocaine; Male; Myocardial Infarction; Purkinje Fibers; Sodium Channels; Tetrodotoxin | 1989 |
Properties of persistent sodium conductance and calcium conductance of layer V neurons from cat sensorimotor cortex in vitro.
Topics: Animals; Barium; Calcium; Cats; Evoked Potentials; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Motor Cortex; Sodium; Somatosensory Cortex; Tetrodotoxin | 1985 |
Comparative effects of tetrodotoxin, lidocaine, and amiodarone on Vmax in guinea pig cardiac Purkinje and papillary muscle fibers.
Topics: Action Potentials; Amiodarone; Animals; Electric Stimulation; Guinea Pigs; Heart; Heart Conduction System; In Vitro Techniques; Kinetics; Lidocaine; Myocardial Contraction; Papillary Muscles; Purkinje Fibers; Tetrodotoxin | 1989 |
[Effects of volatile anesthetics on conduction and maximum rate of rise of action potential upstroke in guinea-pig papillary muscles].
Topics: Action Potentials; Anesthesia, Inhalation; Animals; Electric Conductivity; Enflurane; Guinea Pigs; Halothane; In Vitro Techniques; Isoflurane; Lidocaine; Papillary Muscles; Tetrodotoxin | 1989 |
[Effect of enteric nervous system on anti-peristaltic discharge].
Topics: Action Potentials; Anesthesia, Local; Animals; Cholinesterase Inhibitors; Dogs; Electromyography; Fluorenes; Gastrointestinal Motility; Hexamethonium Compounds; Lidocaine; Mucous Membrane; Myenteric Plexus; Peristalsis; Pylorus; Stomach; Tetrodotoxin | 1989 |
Local anaesthesia of the trachea and mucus secretion.
Topics: Anesthetics, Local; Animals; Cats; Electric Stimulation; Lidocaine; Mucus; Pilocarpine; Tetrodotoxin; Trachea; Vagus Nerve | 1989 |
An aminopyridine-sensitive, early outward current recorded in vivo in neurons of the precruciate cortex of cats using single-electrode voltage-clamp techniques.
Topics: Aminopyridines; Animals; Cats; Cerebral Cortex; Lidocaine; Membrane Potentials; Tetrodotoxin | 1989 |
Comparative effects of three class I antiarrhythmic drugs on plateau and pacemaker currents of sheep cardiac Purkinje fibres.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channels; Disopyramide; Heart Conduction System; Lidocaine; Membrane Potentials; Potassium Channels; Propylamines; Purkinje Fibers; Pyridines; Sheep; Sodium Channels; Tetrodotoxin | 1988 |
The enteric nervous system participates in the secretory response to the heat stable enterotoxins of Escherichia coli in rats and cats.
Topics: Animals; Cats; Drug Interactions; Enterotoxins; Escherichia coli; Female; Hexamethonium; Hexamethonium Compounds; Intestinal Mucosa; Intestine, Small; Lidocaine; Male; Rats; Rats, Inbred Strains; Species Specificity; Tetrodotoxin | 1985 |
Contribution of neurogenic and myogenic factors in the response of rat proximal colon to distension.
Topics: Animals; Atropine; Colon; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Hydroxydopamines; In Vitro Techniques; Lidocaine; Male; Mechanoreceptors; Muscle Contraction; Muscle, Smooth; Oxidopamine; Periodicity; Physostigmine; Procaine; Rats; Stress, Mechanical; Tetrodotoxin | 1987 |
The role of depolarization in the survival and differentiation of cerebellar granule cells in culture.
Topics: Animals; Antigens, Surface; Calcium; Calcium Channel Blockers; Cell Adhesion; Cell Adhesion Molecules; Cell Count; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; DNA; Glutamates; Glutamic Acid; Lidocaine; Membrane Potentials; Potassium; Rats; Tetrodotoxin | 1987 |
Fluid secretion by gallbladder mucosa in experimental cholecystitis is influenced by intramural nerves.
Topics: Animals; Atropine; Autonomic Nervous System; Body Fluids; Cats; Cholecystitis; Dinoprostone; Female; Gallbladder; Hexamethonium; Hexamethonium Compounds; Lidocaine; Male; Prostaglandins E; Somatostatin; Tetrodotoxin; Water-Electrolyte Balance | 1987 |
Effects of halothane and enflurane on conduction velocity and maximum rate of rise of action potential upstroke in guinea pig papillary muscles.
Topics: Action Potentials; Animals; Enflurane; Female; Guinea Pigs; Halothane; Heart Conduction System; In Vitro Techniques; Lidocaine; Male; Papillary Muscles; Tetrodotoxin | 1989 |
Dual effects of adenosine and adenosine analogues on motor activity of the human fallopian tube.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Fallopian Tubes; Female; Humans; Lidocaine; Menstruation; Middle Aged; Muscle Contraction; Muscle, Smooth; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Tetrodotoxin; Theophylline | 1985 |
Studies on the mode of action of bretylium and guanethidine in post-ganglionic sympathetic nerve fibres.
Topics: Amphetamine; Animals; Autonomic Fibers, Postganglionic; Bretylium Compounds; Bretylium Tosylate; Desipramine; Electrophysiology; Guanethidine; Guinea Pigs; In Vitro Techniques; Lidocaine; Male; Muscle Contraction; Tetrodotoxin; Vas Deferens | 1988 |
Pharmacological analysis of nicotinic relaxation of bovine retractor penis muscle.
Topics: Acetylcholine; Animals; Carbachol; Cattle; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Hexamethonium Compounds; Lidocaine; Male; Mecamylamine; Methylene Blue; Muscle Contraction; Muscle Relaxation; Nicotine; Oxygen; Penis; Scopolamine; Tetrodotoxin | 1988 |
Recovery from use-dependent block of Vmax and restitution of action potential duration in canine cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Disopyramide; Dogs; Electrophysiology; Heart Conduction System; Lidocaine; Mexiletine; Microelectrodes; Purkinje Fibers; Sodium; Tetrodotoxin | 1988 |
Electrical and contractile behavior of large intestinal musculature of piebald mouse model for Hirschsprung's disease.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Epinephrine; Hirschsprung Disease; Intestine, Large; Lidocaine; Membrane Potentials; Mice; Mice, Mutant Strains; Microelectrodes; Muscle Contraction; Tetrodotoxin; Time Factors; Transducers, Pressure | 1986 |
Pharmacological characterization of opossum distal colonic muscularis mucosae in vitro.
Topics: Acetylcholine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Atropine; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Female; Histamine; In Vitro Techniques; Indomethacin; Lidocaine; Male; Muscle Contraction; Muscles; Norepinephrine; Opossums; Phentolamine; Propranolol; Pyrilamine; Tetrodotoxin | 1986 |
The effects of antiarrhythmic drugs, stimulation frequency, and potassium-induced resting membrane potential changes on conduction velocity and dV/dtmax in guinea pig myocardium.
Topics: Animals; Anti-Arrhythmia Agents; Electric Stimulation; Extracellular Space; Guinea Pigs; Heart Conduction System; Lidocaine; Membrane Potentials; Papillary Muscles; Potassium; Quinidine; Tetrodotoxin | 1985 |
Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length.
Topics: Action Potentials; Animals; Dogs; Heart Conduction System; Heart Rate; Lidocaine; Potassium; Purkinje Fibers; Quinidine; Tetrodotoxin | 1985 |
Effects of nerve blocking agents on fast axonal transport of proteins in frog sciatic nerves in vitro.
Topics: Action Potentials; Anesthetics, Local; Animals; Anura; Axonal Transport; Cell Membrane Permeability; In Vitro Techniques; Leucine; Lidocaine; Nerve Tissue Proteins; Neural Conduction; Ouabain; Potassium; Procaine; Rana pipiens; Rana temporaria; Sciatic Nerve; Sodium; Tetracaine; Tetrodotoxin; Tritium | 1973 |
Electrically induced contractions of guinea-pig isolated ileum resistant to tetrodotoxin.
Topics: Acetylcholine; Animals; Cocaine; Cold Temperature; Drug Resistance; Electric Stimulation; Guinea Pigs; Histamine H1 Antagonists; Hypoxia; Ileum; In Vitro Techniques; Lidocaine; Methysergide; Morphine; Muscle Contraction; Muscle, Smooth; Phloretin; Potassium Chloride; Prostaglandins; Scopolamine; Serotonin Antagonists; Tetrodotoxin | 1973 |
Evidence for a non-adrenergic inhibitory nervous pathway in guinea-pig trachea.
Topics: Animals; Atropine; Cyclic AMP; Electric Stimulation; Guanethidine; Guinea Pigs; Hydroxydopamines; Imidazoles; In Vitro Techniques; Lidocaine; Methysergide; Muscle Contraction; Neural Inhibition; Propranolol; Reserpine; Tetrodotoxin; Theophylline; Trachea | 1973 |
Pharmacology of aconitine-induced automaticity on in vitro cat myocardial preparations. II. Effects of refractory period prolongation, reduced sodium and tetrodotoxin.
Topics: Aconitum; Animals; Bretylium Compounds; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Ethanolamines; Heart; Heart Rate; In Vitro Techniques; Lidocaine; Neural Conduction; Papillary Muscles; Perfusion; Permeability; Phenytoin; Practolol; Procainamide; Propranolol; Quinidine; Refractory Period, Electrophysiological; Sodium; Tetrodotoxin; Time Factors | 1974 |
Increase in brain dopamine after axotomy or treatment with gammahydroxybutyric acid due to elimination of the nerve impulse flow.
Topics: Animals; Basal Ganglia; Brain; Dopamine; Hydroxybutyrates; Lidocaine; Male; Methyltyrosines; Nerve Endings; Neural Conduction; Norepinephrine; Potassium Chloride; Rats; Sodium Chloride; Substantia Nigra; Tetrodotoxin; Thalamus | 1973 |
On a relationship between ion transport and thiamine in nervous tissue.
Topics: Acetylcholine; Animals; Anura; Biological Transport; Carbachol; Choline; Dopamine; Edetic Acid; Electric Stimulation; Ions; Isoflurophate; Lidocaine; Male; Norepinephrine; Ouabain; Potassium Chloride; Sodium Chloride; Spinal Cord; Sulfur Isotopes; Synaptic Transmission; Tetrodotoxin; Thiamine | 1969 |
Excitation of intestinal muscle by atropine, tetrodotoxin, and xylocaine.
Topics: Acetylcholine; Action Potentials; Animals; Atropa belladonna; Atropine; Cats; Electric Stimulation; Gastrointestinal Motility; Guanethidine; Intestine, Small; Jejunum; Lidocaine; Methacholine Compounds; Muscle, Smooth; Physostigmine; Plants, Medicinal; Plants, Toxic; Procaine; Stimulation, Chemical; Synaptic Transmission; Tetrodotoxin | 1972 |
Electrophysiological and pharmacological properties of the stomach of the squid Loligo pealii (Lesueur).
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Depression, Chemical; Electrophysiology; Epinephrine; Ethanolamines; Gastrointestinal Motility; Lidocaine; Mollusca; Muscle, Smooth; Nicotine; Phenoxybenzamine; Procaine; Quinones; Scopolamine; Serotonin; Stomach; Tetrodotoxin; Tubocurarine | 1969 |
Studies on the intestinal vasodilatation observed after mechanical stimulation of the mucosa of the gut.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Autonomic Nerve Block; Bile; Blood Pressure; Cats; Chlorisondamine; Dilatation; Intestinal Mucosa; Intestines; Jejunum; Lidocaine; Lysergic Acid Diethylamide; Muscles; Regional Blood Flow; Serotonin; Serotonin Antagonists; Tetrodotoxin; Vasomotor System | 1971 |
Sodium ion movements and the spontaneous and electrically stimulated release of ( 3 H)GABA and ( 14 C)glutamic acid from rat cortical slices.
Topics: Aminobutyrates; Animals; Carbon Isotopes; Cerebral Cortex; Electric Stimulation; Extracellular Space; Glutamates; In Vitro Techniques; Inulin; Lidocaine; Membrane Potentials; Neurotransmitter Agents; Ouabain; Potassium; Rats; Sodium; Synaptic Transmission; Tetrodotoxin; Tritium | 1972 |
Effects of procaine and lignocaine on electrical and mechanical activity of smooth muscle of sheep carotid arteries.
Topics: Animals; Carotid Arteries; Dose-Response Relationship, Drug; Electrophysiology; In Vitro Techniques; Lidocaine; Muscle Contraction; Muscle, Smooth; Norepinephrine; Potassium; Procaine; Sheep; Tetrodotoxin; Time Factors | 1974 |
Antiarrhythmic action of tetrodotoxin in various animal species.
Topics: Animals; Anti-Arrhythmia Agents; Bufonidae; Chick Embryo; Cyprinidae; Heart Atria; Heart Conduction System; Heart Ventricles; In Vitro Techniques; Lidocaine; Microelectrodes; Tetrodotoxin | 1973 |
Effects of anesthetics on sodium uptake into rat brain cortex in vitro.
Topics: Amobarbital; Anesthetics, Local; Animals; Brain Chemistry; Calcium; Cerebral Cortex; Cocaine; Dinitrophenols; Glucose; In Vitro Techniques; Lidocaine; Manometry; Oxygen Consumption; Potassium; Potassium Chloride; Protoveratrines; Rats; Sodium; Sodium Isotopes; Tetrodotoxin; Thiopental; Water | 1972 |
Effects of atropine, tetrodotoxin and lidocaine on rebound excitation of guinea-pig small intestine.
Topics: Action Potentials; Animals; Atropine; Dose-Response Relationship, Drug; Electric Stimulation; Guanethidine; Guinea Pigs; Intestine, Small; Lidocaine; Muscle Contraction; Procaine; Tetrodotoxin | 1973 |
Characterization of batrachotoxin-induced depolarization of the squid giant axons.
Topics: Alkaloids; Animals; Antitoxins; Anura; Axons; Cell Membrane; Decapodiformes; Dose-Response Relationship, Drug; Hydroxysteroids; In Vitro Techniques; Lidocaine; Lithium; Membrane Potentials; Procaine; Pyrroles; Quaternary Ammonium Compounds; Sodium; Tetrodotoxin; Time Factors; Toxins, Biological | 1973 |
Intestinal vasodilatation in response to transmural electrical field stimulation.
Topics: Animals; Atropine; Cats; Denervation; Dilatation; Electric Stimulation; Electrodes; Female; Isoproterenol; Jejunum; Lidocaine; Male; Parabiosis; Phenoxybenzamine; Propranolol; Regional Blood Flow; Tetrodotoxin | 1973 |
Intestinal motility increased by tetrodotoxin, lidocaine, and procaine.
Topics: Animals; Cats; Gastrointestinal Motility; Injections, Intra-Arterial; Intestines; Lidocaine; Procaine; Regional Blood Flow; Tetrodotoxin | 1973 |
The binding of labelled saxitoxin to the sodium channels in nerve membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium; Cell Membrane; Fishes; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lidocaine; Neurons; Olfactory Nerve; Rabbits; Saxitoxin; Sodium; Tetrodotoxin; Thallium; Tritium; Vagus Nerve; Veratrine | 1973 |
[Adrenergic and cholinergic mechanisms in the hypogastric nerve-seminal vesicle preparation of the guinea-pig (author's transl)].
Topics: Acetylcholine; Animals; Atropine; Carbachol; Epinephrine; Guanethidine; Guinea Pigs; Hexamethonium Compounds; Hypogastric Plexus; In Vitro Techniques; Lidocaine; Male; Methacholine Compounds; Neostigmine; Nialamide; Nicotine; Norepinephrine; Phenoxybenzamine; Phenylephrine; Physostigmine; Seminal Vesicles; Sympathetic Nervous System; Tetrodotoxin | 1973 |
Contractions and mechanical properties of dogfish spiral intestine rotator muscle.
Topics: Animals; Elasticity; Electric Stimulation; Female; Intestines; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Phenoxybenzamine; Sharks; Stress, Mechanical; Tetrodotoxin | 1974 |
Calcium reversal of nerve blockade by alcohols, anesthetics, tranquilizers, and barbiturates.
Topics: Action Potentials; Alcohols; Anesthetics; Animals; Barbiturates; Benzyl Compounds; Buffers; Calcium; Carbon Radioisotopes; Chlorpromazine; Imipramine; In Vitro Techniques; Lidocaine; Membranes; Nerve Block; Neural Conduction; Pentobarbital; Phrenic Nerve; Procaine; Promethazine; Rats; Sulfur Radioisotopes; Tetrodotoxin; Thymol; Time Factors; Tranquilizing Agents | 1974 |
Functions of neurons in enteric plexuses of cat intestine.
Topics: Acetylcholine; Animals; Atropine; Cats; Electrophysiology; Epinephrine; Hexamethonium Compounds; In Vitro Techniques; Intestine, Small; Lidocaine; Muscle, Smooth; Myenteric Plexus; Neural Inhibition; Nicotine; Norepinephrine; Phenoxybenzamine; Serotonin; Sotalol; Submucous Plexus; Tetrodotoxin; Tubocurarine | 1972 |
Factors that affect the binding and uptake of gaba by brain tissue.
Topics: Acetylcholine; Aminobutyrates; Animals; Brain; Bromides; Cerebral Cortex; Cevanes; Chloral Hydrate; Chlorides; Chlorpromazine; Dopamine; Glutamates; Imipramine; Iodides; Lidocaine; Neostigmine; Norepinephrine; Ouabain; Phosphates; Picrotoxin; Procaine; Rats; Sodium Chloride; Tetrodotoxin | 1971 |
[Effects of some chemicals on the ERG of the albino rabbit retina].
Topics: Animals; Electroretinography; Ethanol; In Vitro Techniques; Lidocaine; Pentobarbital; Potassium Chloride; Rabbits; Retina; Tetrodotoxin | 1971 |
[Is the oscillatory potential in the ERG responsible for the activity of the optic nerve?].
Topics: Electroretinography; Evoked Potentials; Lidocaine; Optic Nerve; Tetrodotoxin | 1969 |
Mechanical interaction between longitudinal and circular axes of the small intestine.
Topics: Animals; Biomechanical Phenomena; Calcium; Cats; Electric Stimulation; Gastrointestinal Motility; In Vitro Techniques; Intestine, Small; Jejunum; Lidocaine; Muscle Contraction; Muscle, Smooth; Potassium; Potassium Chloride; Procaine; Sodium; Sodium Chloride; Sulfates; Tetrodotoxin | 1970 |
Adrenergic mechanisms in the relaxation of guinea-pig taenia coli in vitro.
Topics: Animals; Catecholamines; Colon; Electric Stimulation; Female; Guanethidine; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nicotine; Phentolamine; Potassium; Propranolol; Sympathetic Nervous System; Tetrodotoxin; Tolazoline | 1971 |
[Effects of intravitreous injection of several chemicals on the ERG and the light-induced optic nerve potential in the albino rabbit].
Topics: Action Potentials; Animals; Cyanides; Electroretinography; Injections, Intravenous; Lidocaine; Light; Optic Nerve; Pentobarbital; Picrotoxin; Potassium Chloride; Rabbits; Strychnine; Tetrodotoxin; Vitreous Body | 1968 |
Action of prostaglandin E 1 on the longitudinal muscle of the guinea-pig isolated colon.
Topics: Acetylcholine; Animals; Cocaine; Colon; Guinea Pigs; In Vitro Techniques; Lidocaine; Muscle, Smooth; Nicotine; Prostaglandins; Scopolamine; Tetrodotoxin | 1969 |
Common mode of action of three agents that decrease the transient change in sodium permeability in nerves.
Topics: Action Potentials; Animals; Anura; Cell Membrane Permeability; Electrophysiology; Lidocaine; Myelin Sheath; Nerve Tissue; Prochlorperazine; Ranvier's Nodes; Sodium; Tetrodotoxin; Toxins, Biological | 1966 |
The selective inhibition of delayed potassium currents in nerve by tetraethylammonium ion.
Topics: Action Potentials; Animals; Anura; Calcium; Cell Membrane Permeability; Computers; Electrophysiology; Lidocaine; Myelin Sheath; Potassium; Quaternary Ammonium Compounds; Ranvier's Nodes; Sodium; Tetraethylammonium Compounds; Tetrodotoxin; Toxins, Biological | 1967 |
Field-stimulus response of guinea-pig atria as influenced by the peptides angiotensin, bradykinin, and substance P.
Topics: Angiotensin II; Animals; Bradykinin; Electric Stimulation; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Pindolol; Substance P; Tetrodotoxin; Vas Deferens | 1980 |
[Tetrodotoxin potentiation of the antiarrhythmic action of lidocaine in the late stage of experimental myocardial infarct].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Dogs; Drug Therapy, Combination; Female; Ion Channels; Lidocaine; Male; Myocardial Infarction; Myocardium; Sodium; Tetrodotoxin | 1981 |
Endoluminal substance P as a cause of mucosal hyperemia in the feline gut by a nonneural mechanism.
Topics: Animals; Cats; Hyperemia; Intestinal Mucosa; Jejunum; Lidocaine; Male; Microspheres; Perfusion; Peristalsis; Regional Blood Flow; Substance P; Tetrodotoxin; Time Factors | 1983 |
Mechanisms of action of lidocaine and quinidine on action potential duration in rabbit cardiac Purkinje fibers. An effect on steady state sodium currents?
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Heart Conduction System; Ion Channels; Lidocaine; Male; Purkinje Fibers; Quinidine; Rabbits; Tetrodotoxin; Time Factors | 1982 |
Shortening of the action potential and reduction of pacemaker activity by lidocaine, quinidine, and procainamide in sheep cardiac purkinje fibers. An effect on Na or K currents?
Topics: Action Potentials; Animals; Barium; Cardiac Pacing, Artificial; Electrophysiology; Heart Conduction System; Ion Channels; Lidocaine; Procainamide; Purkinje Fibers; Quinidine; Tetrodotoxin; Time Factors | 1982 |
Effects of local anesthetic QX-314 on the membrane properties of hippocampal pyramidal neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Membranes; Microelectrodes; Neurons; Pyramidal Tracts; Synapses; Synaptic Transmission; Tetrodotoxin | 1982 |
Sodium currents in segments of human heart cells.
Topics: Cells, Cultured; Humans; Ion Channels; Lidocaine; Membrane Potentials; Myocardium; Sodium; Tetrodotoxin | 1983 |
The role of intracellular sodium activity in the anti-arrhythmic action of local anaesthetics in sheep Purkinje fibres.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Biological Transport, Active; Heart Conduction System; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Purkinje Fibers; Sheep; Sodium; Tetrodotoxin | 1983 |
The involvement of the enteric nervous system in the intestinal secretion evoked by cyclic adenosine 3'5'-monophosphate.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Bucladesine; Cats; Denervation; Female; Gastrointestinal Motility; Hexamethonium Compounds; Intestinal Mucosa; Intestines; Lidocaine; Male; Rats; Rats, Inbred Strains; Regional Blood Flow; Tetrodotoxin; Theophylline | 1984 |
Control of phosphorylase in cultured rat skeletal muscle cells. Changes in synthesis and degradation resulting from differentiation and muscle activity.
Topics: Animals; Antigen-Antibody Complex; Cell Differentiation; Cells, Cultured; Chromatography, Affinity; Cycloheximide; Immune Sera; Kinetics; Lidocaine; Muscles; Phosphorylase b; Phosphorylases; Rats; Tetrodotoxin | 1984 |
Cycle length-dependent action potential duration in canine cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Cobalt; Dogs; Female; Heart Conduction System; Homeostasis; In Vitro Techniques; Isoproterenol; Kinetics; Lidocaine; Male; Purkinje Fibers; Reaction Time; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Verapamil | 1984 |
[Autonomic nerve innervation of cat pulmonary artery--with special reference to the presence of a non-adrenergic, non-cholinergic inhibitory system].
Topics: Animals; Atropine; Autonomic Nervous System; Cats; Female; In Vitro Techniques; Lidocaine; Male; Neural Inhibition; Phenoxybenzamine; Propranolol; Pulmonary Artery; Pulmonary Circulation; Tetrodotoxin; Vasoconstriction; Vasodilation | 1984 |
The effects of sodium selenite on rat diaphragm muscle.
Topics: Animals; Caffeine; Diaphragm; Electric Stimulation; Female; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Muscles; Potassium Chloride; Procaine; Rats; Selenious Acid; Selenium; Tetrodotoxin | 1983 |
The importance of the enteric nervous system for the bile-salt-induced secretion in the small intestine of the rat.
Topics: Animals; Atropine; Blood Pressure; Denervation; Deoxycholic Acid; Female; Gastrointestinal Motility; Hexamethonium Compounds; Jejunum; Lidocaine; Male; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Tetrodotoxin | 1983 |
The involvement of intramural nerves in cholera toxin induced intestinal secretion.
Topics: Animals; Cats; Cholera; Cholera Toxin; Female; Hexamethonium Compounds; Intestinal Secretions; Intestine, Small; Lidocaine; Male; Neurons; Rats; Rats, Inbred Strains; Reflex; Tetrodotoxin; Vasoactive Intestinal Peptide | 1983 |
Developmental and neurochemical specificity of neuronal deficits produced by electrical impulse blockade in dissociated spinal cord cultures.
Topics: Animals; Culture Techniques; Fetus; gamma-Aminobutyric Acid; Ganglia, Spinal; Lidocaine; Mice; Mice, Inbred C57BL; Nerve Block; Neurons; Spinal Cord; Tetrodotoxin | 1983 |
The basis for the membrane potential of quiescent cells of the canine coronary sinus.
Topics: Acetylcholine; Animals; Carbachol; Chlorides; Coronary Vessels; Dogs; In Vitro Techniques; Lidocaine; Membrane Potentials; Osmolar Concentration; Potassium; Sodium; Tetrodotoxin | 1983 |
Amantadine-induced diastolic depolarization and automaticity in ventricular muscle.
Topics: Action Potentials; Amantadine; Animals; Catecholamines; Cats; Diastole; Dogs; Electrophysiology; Heart; Lidocaine; Membrane Potentials; Rabbits; Rana pipiens; Tetrodotoxin; Ventricular Function; Verapamil | 1982 |
The effect of intestinal fluid transport of exposing the serosa to hydrochloric acid. A study of mechanisms.
Topics: Animals; Atropine; Cats; Female; Hexamethonium Compounds; Hydrochloric Acid; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Intestinal Secretions; Jejunum; Lidocaine; Male; Rats; Rats, Inbred Strains; Tetrodotoxin | 1982 |
Comparison of the chronotropic responses to local anesthetics (procaine, lidocaine, prilocaine, mepivacaine and bupivacaine) of the canine sinus node in situ.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Lidocaine; Male; Mepivacaine; Prilocaine; Procaine; Propranolol; Reserpine; Sinoatrial Node; Tetrodotoxin | 1981 |
Electromechanical effects of anthopleurin-A (AP-A) on rabbit ventricular muscle: influence of driving frequency, calcium antagonists, tetrodotoxin, lidocaine and ryanodine.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Heart Rate; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Lidocaine; Myocardial Contraction; Peptides; Rabbits; Ryanodine; Tetrodotoxin | 1981 |
Effects of tetrodotoxin, lidocaine, verapamil, and AHR-2666 on Ouabain-induced delayed afterdepolarizations in canine Purkinje fibers.
Topics: Action Potentials; Animals; Carbamates; Diastole; Dogs; Heart Conduction System; Ion Channels; Lidocaine; Ouabain; Purkinje Fibers; Pyrrolidines; Tetrodotoxin; Time Factors; Verapamil | 1980 |
The intracellular sodium activity of sheep heart Purkinje fibres: effects of local anaesthetics and tetrodotoxin.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Heart Conduction System; In Vitro Techniques; Intracellular Fluid; Lidocaine; Membrane Potentials; Procaine; Purkinje Fibers; Sheep; Sodium; Strophanthidin; Tetrodotoxin | 1980 |
Mechanisms for impulse initiation in isolated human atrial fibers.
Topics: Acetylcholine; Action Potentials; Adolescent; Adult; Carbamates; Child; Child, Preschool; Electrophysiology; Epinephrine; Heart Atria; Heart Conduction System; Heart Rate; Humans; Infant; Lidocaine; Middle Aged; Myocardial Contraction; Pyrrolidines; Tetrodotoxin; Time Factors; Verapamil | 1980 |
Differential sensitivities of mammalian nerve fibers to local anesthetic agents.
Topics: Anesthetics; Animals; Bupivacaine; Cocaine; Etidocaine; Lidocaine; Nerve Fibers; Nerve Fibers, Myelinated; Procaine; Rabbits; Saxitoxin; Tetracaine; Tetrodotoxin | 1980 |
The entorhinal cortex entrains fast CA1 hippocampal oscillations in the anaesthetized guinea-pig: role of the monosynaptic component of the perforant path.
Topics: Animals; Electrophysiology; Entorhinal Cortex; Female; Guinea Pigs; Hippocampus; Injections; Lidocaine; Neurons; Oscillometry; Synapses; Tetrodotoxin; Time Factors | 1995 |
Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels.
Topics: Animals; Bupivacaine; Demyelinating Diseases; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channel Gating; Lidocaine; Male; Nerve Block; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Reaction Time; Sensation Disorders; Sodium Channel Blockers; Sodium Channels; Spinal Cord; Spinal Nerve Roots; Tetrodotoxin | 1995 |
Effect of scorpion toxin from Tityus serrulatus on the contraction of the isolated rat uterus.
Topics: Acetylcholine; Angiotensin II; Animals; Atropine; Bradykinin; Chemical Fractionation; Drug Interactions; Drug Synergism; Female; Hexamethonium; In Vitro Techniques; Lidocaine; Neostigmine; Rats; Receptors, Muscarinic; Scorpion Venoms; Scorpions; Serotonin Antagonists; Tetrodotoxin; Toxins, Biological; Uterine Contraction | 1995 |
Ionic contributions to the oscillatory firing activity of rat Purkinje cells in vitro.
Topics: Action Potentials; Anesthetics, Local; Animals; Cell Membrane; Cesium; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Neurotransmitter Agents; Purkinje Cells; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin | 1993 |
R 56 865, a Na+/Ca(2+)-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Dose-Response Relationship, Drug; Hemodynamics; Lidocaine; Male; Piperidines; Random Allocation; Rats; Rats, Wistar; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Verapamil | 1993 |
Subanesthetic concentrations of lidocaine selectively inhibit a nociceptive response in the isolated rat spinal cord.
Topics: Animals; Butylamines; Female; In Vitro Techniques; Lidocaine; Male; Naloxone; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Tetrodotoxin | 1995 |
Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine.
Topics: Cell Differentiation; Electrophysiology; Humans; Imidazoles; Kinetics; Lidocaine; Membrane Potentials; Neuroblastoma; Patch-Clamp Techniques; Piperazines; Sodium Channels; Tetrodotoxin; Tumor Cells, Cultured | 1994 |
Damage from oxygen and glucose deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials.
Topics: Action Potentials; Animals; Brain Ischemia; Evoked Potentials; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Lidocaine; Male; Phenytoin; Rats; Rats, Wistar; Synaptic Transmission; Tetrodotoxin | 1994 |
Effects of locally applied cocaine, lidocaine, and various uptake blockers on monoamine transmission in the ventral tegmental area of freely moving rats: a microdialysis study on monoamine interrelationships.
Topics: Animals; Biogenic Monoamines; Citalopram; Cocaine; Desipramine; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Lidocaine; Ligands; Male; Microdialysis; Movement; Norepinephrine; Piperazines; Rats; Serotonin; Tetrodotoxin; Ventral Tegmental Area | 1994 |
Contrasting actions of cocaine, local anaesthetic and tetrodotoxin on discharge properties of rat aortic baroreceptors.
Topics: Anesthetics, Local; Animals; Aorta, Thoracic; Benzocaine; Cocaine; Dose-Response Relationship, Drug; In Vitro Techniques; Lidocaine; Male; Pressoreceptors; Pressure; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin | 1994 |
Mechanism of mesenteric venodilatation after epidural lidocaine in rabbits.
Topics: Administration, Topical; Anesthesia, Epidural; Animals; Blood Pressure; Catheterization; Epinephrine; Injections, Epidural; Lidocaine; Male; Mesenteric Veins; Mesentery; Norepinephrine; Rabbits; Tetrodotoxin; Vasodilation | 1994 |
Role of junctional zone cells between Purkinje fibres and ventricular muscle in arrhythmogenesis.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Dogs; Edetic Acid; Female; Heart Ventricles; Lidocaine; Male; Membrane Potentials; Myocardium; Purkinje Fibers; Tetrodotoxin; Verapamil | 1994 |
Fast presynaptic GABAA receptor-mediated Cl- conductance in cultured rat hippocampal neurones.
Topics: Animals; Bicuculline; Cells, Cultured; Chloride Channels; Chlorides; Female; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lidocaine; Neurons; Picrotoxin; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Presynaptic; Synapses; Synaptic Transmission; Tetrodotoxin | 1994 |
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.
Topics: Amiloride; Animals; Benzofurans; Benzothiazoles; Calcium; Calcium Channel Blockers; Cell Separation; Ethers, Cyclic; Fluorescent Dyes; Hypoxia; Lidocaine; Myocardial Contraction; Myocardium; Piperidines; Rats; Sodium; Sodium Channel Blockers; Sodium-Hydrogen Exchangers; Tetrodotoxin; Thiazoles | 1994 |
The behavioral response induced by intravesical instillation of capsaicin rats is mediated by pudendal urethral sensory fibers.
Topics: Animals; Behavior, Animal; Capsaicin; Female; Lidocaine; Male; Neurons, Afferent; Rats; Rats, Wistar; Tetrodotoxin; Urethra; Urinary Bladder | 1994 |
Pharmacological modulation of human cardiac Na+ channels.
Topics: Animals; Azetidines; Cardiotonic Agents; Electrophysiology; Female; Flecainide; Humans; Lidocaine; Mercaptopurine; Myocardium; Oocytes; Piperazines; Quinidine; RNA, Complementary; Sodium Channels; Tetrodotoxin; Transcription, Genetic; Xenopus laevis | 1994 |
Inhibition of brain cell excitability by lidocaine, QX314, and tetrodotoxin: a mechanism for analgesia from infused local anesthetics?
Topics: Analgesia; Anesthetics, Local; Animals; Brain; In Vitro Techniques; Infusions, Intravenous; Lidocaine; Male; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1993 |
Nutrient-induced changes in the permeability of the rat jejunal mucosa.
Topics: Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Glucose; Hexamethonium Compounds; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Lidocaine; Male; Mannitol; Neurons; Perfusion; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tetrodotoxin | 1993 |
Mechanisms of the secretory response to luminal propionate in rat descending colon in vitro.
Topics: Acetylcholine; Animals; Atropine; Calcium Channel Blockers; Chlorides; Colon; Dinoprostone; Electric Stimulation; Female; Guinea Pigs; Hexamethonium Compounds; Histamine; Humans; In Vitro Techniques; Lidocaine; Male; Nerve Endings; Neuropeptides; omega-Conotoxins; Peptides; Piroxicam; Propionates; Rabbits; Rats; Serotonin; Serotonin Antagonists; Tachyphylaxis; Tetrodotoxin | 1993 |
The local anaesthetic QX-314 enables enhanced whole-cell recordings of excitatory synaptic currents in rat hippocampal slices in vitro.
Topics: Anesthetics, Local; Animals; Cadmium; Cadmium Chloride; Chlorides; Hippocampus; In Vitro Techniques; Lidocaine; Potassium Channels; Pyramidal Tracts; Rats; Sodium Channels; Synapses; Tetrodotoxin | 1993 |
Block of voltage-dependent sodium currents by the substance P receptor antagonist (+/-)-CP-96,345 in neurones cultured from rat cortex.
Topics: Animals; Biphenyl Compounds; Cells, Cultured; Cerebral Cortex; Electrophysiology; Female; Hypnotics and Sedatives; Kinetics; Lidocaine; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons; Pregnancy; Rats; Sodium Channels; Tetrodotoxin | 1993 |
Cocaine inhibits hippocampal long-term potentiation.
Topics: Animals; Cocaine; Dextroamphetamine; Electric Stimulation; Hippocampus; In Vitro Techniques; Learning; Lidocaine; Memory; Neuronal Plasticity; Phosphorylation; Procaine; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1993 |
Inhibition of Na+/Ca2+ overload with R 56,865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs.
Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Electrocardiography; Guinea Pigs; Heart Rate; Lidocaine; Male; Ouabain; Piperidines; Sodium; Tetrodotoxin; Thiazoles; Verapamil | 1993 |
Effect of spike blockade on the receptive-field size of amacrine and ganglion cells in the rabbit retina.
Topics: Anesthetics, Local; Animals; Cell Size; Dendrites; Evoked Potentials, Visual; Ion Channel Gating; Lidocaine; Microelectrodes; Photic Stimulation; Rabbits; Receptors, Presynaptic; Retina; Retinal Ganglion Cells; Sodium Channels; Tetrodotoxin; Visual Fields | 1996 |
Pharmacologic studies on the mechanism of melatonin-induced vasorelaxation in rat aorta.
Topics: Animals; Aorta, Thoracic; Atropine; Dose-Response Relationship, Drug; Lidocaine; Male; Melatonin; Muscle Relaxation; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Substance P; Sympatholytics; Tetrodotoxin; Vasoactive Intestinal Peptide; Vasoconstriction; Vasomotor System | 1995 |
Arrhythmias caused by platelet activating factor.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Female; Lidocaine; Male; Membrane Potentials; Patch-Clamp Techniques; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetrodotoxin | 1996 |
Effects of reversible inactivations of the medial septal area on reference and working memory versions of the Morris water maze.
Topics: Animals; Escape Reaction; Lidocaine; Male; Maze Learning; Memory; Rats; Rats, Inbred Strains; Reaction Time; Septum Pellucidum; Tetrodotoxin; Time Factors | 1996 |
Electrotonic coupling between rat sympathetic preganglionic neurones in vitro.
Topics: Action Potentials; Adrenergic Fibers; Anesthetics, Local; Animals; Autonomic Fibers, Preganglionic; Calcium; Electrophysiology; Gap Junctions; Lidocaine; Membrane Potentials; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord; Tetrodotoxin | 1996 |
Kinetics of slow inactivation of persistent sodium current in layer V neurons of mouse neocortical slices.
Topics: Anesthetics, Local; Animals; Axons; Cerebral Cortex; Cesium; Electrophysiology; Female; Kinetics; Lidocaine; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Neurons; Patch-Clamp Techniques; Sodium Channels; Tetrodotoxin | 1996 |
Hypoxia increases persistent sodium current in rat ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Electrophysiology; Heart Ventricles; Hypoxia; Ion Channel Gating; Lidocaine; Membrane Potentials; Myocardium; Rats; Rats, Wistar; Sodium; Sodium Channels; Tetrodotoxin; Time Factors | 1996 |
Tetrodotoxin-resistant Na+ spikes of C fibers have at least two subtypes in the isolated bullfrog sciatic nerve.
Topics: Action Potentials; Anesthetics, Local; Animals; Cadmium; Capsaicin; Electric Stimulation; Electrophysiology; Lidocaine; Nerve Fibers; Rana catesbeiana; Sciatic Nerve; Sodium; Tetrodotoxin | 1996 |
A novel tetrodotoxin-sensitive Na+ current in cultured human coronary myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adult; Calcium Channel Agonists; Calcium Channel Blockers; Cnidarian Venoms; Coronary Vessels; Dose-Response Relationship, Drug; Humans; Ion Channel Gating; Lidocaine; Male; Middle Aged; Muscle, Smooth, Vascular; Neurotoxins; Nicardipine; Patch-Clamp Techniques; Sodium Channels; Tetrodotoxin; Veratridine | 1997 |
Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury.
Topics: Anesthetics, Local; Animals; Axons; Denervation; Down-Regulation; Female; Ganglia, Spinal; Ion Channel Gating; Kinetics; Lidocaine; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium; Sodium Channel Agonists; Sodium Channel Blockers; Sodium Channels; Spinal Cord; Tetrodotoxin; Up-Regulation | 1997 |
Sodium channel modulators prevent oxygen and glucose deprivation injury and glutamate release in rat neocortical cultures.
Topics: Animals; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; L-Lactate Dehydrogenase; Lidocaine; Neurons; Phenytoin; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Tetrodotoxin | 1997 |
Sodium channel blockade unmasks two temporally distinct mechanisms of striatal dopamine release during hypoxia/hypoglycaemia in vitro.
Topics: Animals; Dopamine; Electrophysiology; Extracellular Space; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Lidocaine; Male; Neostriatum; Phenytoin; Rats; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin | 1997 |
Properties of calcium spikes revealed during GABAA receptor antagonism in hippocampal CA1 neurons from guinea pigs.
Topics: Animals; Bicuculline; Cadmium; Calcium; Calcium Channel Blockers; Electric Stimulation; Electrophysiology; Evoked Potentials; GABA-A Receptor Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Nifedipine; omega-Agatoxin IVA; Picrotoxin; Pyramidal Cells; Sodium Channel Blockers; Spider Venoms; Tetrodotoxin; Virulence Factors, Bordetella | 1997 |
DMPP causes relaxation of rat distal colon by a purinergic and a nitrergic mechanism.
Topics: Adenosine Triphosphate; Anesthetics, Local; Animals; Carbachol; Colon; Dimethylphenylpiperazinium Iodide; Ganglionic Blockers; Ganglionic Stimulants; Hexamethonium; In Vitro Techniques; Lidocaine; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitroprusside; Papaverine; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Synaptic Transmission; Tetrodotoxin; Vasodilator Agents | 1997 |
The regional vulnerability to blockade of action potentials in organotypic hippocampal culture.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Hippocampus; Lidocaine; Neurons; Organ Culture Techniques; Picrotoxin; Rats; Sodium Channel Blockers; Synapses; Synaptic Transmission; Tetrodotoxin | 1997 |
NMDA receptor activation triggers voltage oscillations, plateau potentials and bursting in neonatal rat lumbar motoneurons in vitro.
Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Electric Stimulation; Excitatory Amino Acid Agonists; Ganglia, Spinal; Lidocaine; Motor Neurons; N-Methylaspartate; Patch-Clamp Techniques; Periodicity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin; Tetrodotoxin | 1997 |
Complex blockade of TTX-resistant Na+ currents by lidocaine and bupivacaine reduce firing frequency in DRG neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Bupivacaine; Drug Resistance; Female; Ganglia, Spinal; In Vitro Techniques; Lidocaine; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin | 1998 |
Na+ channel block prevents the ischemia-induced release of norepinephrine from spinal cord slices.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Calcium; Calcium Channel Blockers; Cold Temperature; Hypoglycemia; Hypoxia; Ischemia; Lidocaine; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Spinal Cord; Tetrodotoxin | 1998 |
Inhibition of oxidative metabolism increases persistent sodium current in rat CA1 hippocampal neurons.
Topics: Animals; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Hippocampus; Lidocaine; Membrane Potentials; Neurons; Oxidation-Reduction; Oxidative Phosphorylation; Patch-Clamp Techniques; Rats; Sodium Channels; Sodium Cyanide; Tetrodotoxin | 1998 |
Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea.
Topics: Animals; Capsaicin; Ciliary Body; Cornea; Electric Stimulation; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Lidocaine; Nerve Endings; Nociceptors; Reaction Time; Sodium Channels; Tetrodotoxin | 1998 |
Functional and ionic properties of a slow afterhyperpolarization in ferret perigeniculate neurons in vitro.
Topics: Action Potentials; Anesthetics, Local; Animals; Apamin; Bicuculline; Calcium; Calcium Channel Blockers; Excitatory Postsynaptic Potentials; Female; Ferrets; GABA Antagonists; gamma-Aminobutyric Acid; Geniculate Bodies; Lidocaine; Male; Neurons; omega-Conotoxin GVIA; Peptides; Periodicity; Potassium; Potassium Channels; Sodium; Tetraethylammonium; Tetrodotoxin | 1998 |
The action of local anaesthetics on the compound action potential is altered by the nature of the permeant ion in frog nerve.
Topics: Action Potentials; Anesthetics, Local; Animals; Benzocaine; Dose-Response Relationship, Drug; Lidocaine; Lithium; Procaine; Rana pipiens; Rana temporaria; Sciatic Nerve; Sodium; Sodium Channels; Tetrodotoxin | 1998 |
Electrophysiological evidence for tetrodotoxin-resistant sodium channels in slowly conducting dural sensory fibers.
Topics: Anesthetics, Local; Animals; Axons; Calcium; Drug Resistance; Dura Mater; Lidocaine; Male; Nerve Fibers; Neural Conduction; Neurons, Afferent; Physical Stimulation; Rats; Reaction Time; Sensory Thresholds; Sodium Channels; Tetrodotoxin; Time Factors; Trigeminal Ganglion | 1999 |
Physiological oxygen concentration gives an oscillating spontaneous tone in guinea-pig tracheal preparations.
Topics: Animals; Capsaicin; Electric Stimulation; Guinea Pigs; Heptanol; In Vitro Techniques; Indomethacin; Lidocaine; Male; Muscle Tonus; Muscle, Smooth; Oscillometry; Oxygen; Tetrodotoxin; Trachea | 1999 |
The first-order giant neurons of the giant fiber system in the squid: electrophysiological and ultrastructural observations.
Topics: Action Potentials; Anesthetics, Local; Animals; Axons; Cells, Cultured; Decapodiformes; Electric Stimulation; Escape Reaction; Evoked Potentials; In Vitro Techniques; Lidocaine; Nerve Fibers; Neurons; Synapses; Tetrodotoxin | 1998 |
Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons.
Topics: Animals; Cerebellar Cortex; Electric Stimulation; Excitatory Postsynaptic Potentials; Guinea Pigs; In Vitro Techniques; Interneurons; Lidocaine; Membrane Potentials; Nerve Net; Reaction Time; Synaptic Transmission; Tetrodotoxin | 1999 |
The effects of lignocaine and tetrodotoxin on the action potentials and contractions of left ventricles from normo- and hypertensive rats.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Hypertension; Hypertrophy, Left Ventricular; Lidocaine; Myocardial Contraction; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Channels; Tetrodotoxin; Ventricular Function, Left | 1999 |
Effects of antiarrhythmic drugs on the monophasic action potential of the canine isolated, blood-perfused ventricular septum preparation.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Heart Septum; In Vitro Techniques; Lidocaine; Male; Tetrodotoxin; Verapamil | 1998 |
Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain.
Topics: Afferent Pathways; Animals; Axons; Electric Stimulation; Female; Ganglia, Spinal; Lidocaine; Male; Membrane Potentials; Neural Conduction; Neuritis; Neurons, Afferent; Oscillometry; Pain; Rats; Rats, Wistar; Sodium; Tetrodotoxin | 1999 |
Nitric oxide increases persistent sodium current in rat hippocampal neurons.
Topics: Animals; Cells, Cultured; Dithionitrobenzoic Acid; Dithiothreitol; Hippocampus; Lidocaine; Neurons; Nitric Oxide; Nitroprusside; Patch-Clamp Techniques; Penicillamine; Rats; Rats, Wistar; Sodium Channels; Sodium Cyanide; Tetrodotoxin | 1999 |
K(+)-induced neurogenic relaxation of rat distal colon.
Topics: Animals; Apamin; Carbachol; Colon; Drug Interactions; Enzyme Inhibitors; Hexamethonium; In Vitro Techniques; Lidocaine; Male; Muscle Relaxation; Muscle, Smooth; Nervous System Physiological Phenomena; Nitroprusside; Papaverine; Potassium; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Vasoactive Intestinal Peptide | 1999 |
Role of the enteric nervous system in the fluid and electrolyte secretion of rotavirus diarrhea.
Topics: Animals; Animals, Newborn; Body Water; Diarrhea; Electrolytes; Enteric Nervous System; Hexamethonium; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Lidocaine; Mecamylamine; Mice; Mice, Inbred BALB C; Nicotinic Antagonists; Patch-Clamp Techniques; Rotavirus Infections; Synaptic Transmission; Tetrodotoxin; Theophylline | 2000 |
Locus coeruleus neurones in vitro: pH-sensitive oscillations of membrane potential in an electrically coupled network.
Topics: Acidosis; Animals; Cadmium; Calcium; Cells, Cultured; Culture Media; Hydrogen-Ion Concentration; Hypercapnia; Lidocaine; Locus Coeruleus; Magnesium; Membrane Potentials; Neurons; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1999 |
Initiation of phase III contractions in the jejunum by atropine, hexamethonium and xylocaine in conscious dogs.
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Arginine; Atropine; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Consciousness; Dogs; Enteric Nervous System; Enzyme Inhibitors; Gastrointestinal Motility; Hexamethonium; Indoles; Injections, Intra-Arterial; Jejunum; Lidocaine; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Parasympatholytics; Peptide Fragments; Piperidines; Postprandial Period; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sulfonamides; Tetrodotoxin | 2000 |
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.
Topics: Anesthetics, Local; Animals; Binding Sites; Lidocaine; Muscle, Skeletal; Mutagenesis; Myocardium; NAV1.8 Voltage-Gated Sodium Channel; Protein Isoforms; Rats; Sodium Channels; Tetrodotoxin; Xenopus | 2000 |
Comments on "Differential effects of unilateral lidocaine infusion into the globus pallidus on consolidation and performance of inhibitory avoidance".
Topics: Anesthetics, Local; Animals; Avoidance Learning; Brain Mapping; Dominance, Cerebral; Globus Pallidus; Lidocaine; Mental Recall; Neural Inhibition; Rats; Tetrodotoxin | 2000 |
Differential block of fast and slow inactivating tetrodotoxin-sensitive sodium channels by droperidol in spinal dorsal horn neurons.
Topics: Adjuvants, Anesthesia; Anesthetics, Local; Animals; Cell Separation; Droperidol; In Vitro Techniques; Lidocaine; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Sodium Channel Blockers; Spinal Cord; Tetrodotoxin | 2000 |
Ionic mechanisms underlying repetitive high-frequency burst firing in supragranular cortical neurons.
Topics: Action Potentials; Aging; Animals; Calcium; Chelating Agents; Cycloleucine; Egtazic Acid; Female; Ferrets; In Vitro Techniques; Lidocaine; Male; Neurons; Phenytoin; Potassium; Potassium Channels; Pyramidal Cells; Sodium; Sodium Channels; Tetrodotoxin; Visual Cortex | 2000 |
Mechanism for increase in expression of cerebral diazepam binding inhibitor mRNA by nicotine: involvement of L-type voltage-dependent calcium channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anesthetics, Local; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Radioisotopes; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Diazepam Binding Inhibitor; Dibucaine; Enzyme Inhibitors; Gene Expression; Hexamethonium; Lidocaine; Membrane Potentials; Mice; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; omega-Agatoxin IVA; omega-Conotoxin GVIA; Platelet Aggregation Inhibitors; Procainamide; RNA, Messenger; Sulfonamides; Tetrodotoxin; Tritium | 2000 |
Effects of sodium channel blockade on ibutilide induced prolongation of repolarization in the isolated rabbit ventricle.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Culture Techniques; Disease Models, Animal; Electric Conductivity; Female; Heart Ventricles; Lidocaine; Male; Probability; Rabbits; Reference Values; Sodium Channel Blockers; Sulfonamides; Tetrodotoxin; Ventricular Function | 2000 |
A role for sodium and chloride in kainic acid-induced beading of inhibitory interneuron dendrites.
Topics: Animals; Calcium; Chloride Channels; Chlorides; Dendrites; Dose-Response Relationship, Drug; Epilepsy; Extracellular Space; Hippocampus; Interneurons; Kainic Acid; Lidocaine; Neural Inhibition; Neurotoxins; Parvalbumins; Rats; Rats, Wistar; Sodium Channels; Tetrodotoxin | 2000 |
Oxygen-sensing persistent sodium channels in rat hippocampus.
Topics: Anesthetics, Local; Animals; Antimetabolites; Cell Hypoxia; Cells, Cultured; Hippocampus; Lidocaine; Neurons; Oxidation-Reduction; Oxygen Consumption; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels; Sodium Cyanide; Tetrodotoxin | 2000 |
Tetrodotoxin-resistant action potentials in dorsal root ganglion neurons are blocked by local anesthetics.
Topics: Action Potentials; Anesthetics, Local; Animals; Bupivacaine; Ganglia, Spinal; In Vitro Techniques; Kinetics; Lidocaine; Neurons, Afferent; Patch-Clamp Techniques; Rats; Sodium Channels; Tetrodotoxin | 2000 |
Role of sodium channels in ventricular fibrillation: a study in nonischemic isolated hearts.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Cats; Echocardiography, Three-Dimensional; Electrocardiography; Electrophysiology; Female; Fourier Analysis; Heart; Heart Conduction System; In Vitro Techniques; Lidocaine; Male; Models, Biological; Rabbits; Sodium Channels; Tetrodotoxin; Ventricular Fibrillation | 2000 |
Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na(+) currents in rat sensory neurons.
Topics: Amitriptyline; Analgesics; Anesthetics, Local; Animals; Cells, Cultured; Diethylcarbamazine; Drug Interactions; Electric Stimulation; Lidocaine; Memantine; Membrane Potentials; Mexiletine; Neurons, Afferent; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2001 |
Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels.
Topics: Action Potentials; Anesthetics, Local; Animals; Calcium Channels; Cell Separation; Electrophysiology; In Vitro Techniques; Insecticides; Lidocaine; Membrane Potentials; Neurons; Oxazines; Patch-Clamp Techniques; Periplaneta; Sodium Channel Blockers; Tetrodotoxin | 2001 |
Effects of ATP on intracellular calcium dynamics of the perineurium of peripheral nerve bundles.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anesthetics, Local; Animals; Antineoplastic Agents; Calcium; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Lidocaine; Male; Microscopy, Confocal; Peripheral Nerves; Rats; Rats, Inbred WKY; Sciatic Nerve; Suramin; Tetraethylammonium; Tetrodotoxin; Thapsigargin; Triazines; Uridine Triphosphate | 2000 |
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.
Topics: Amino Acid Substitution; Anesthetics, Local; Animals; Calcium Channel Blockers; Cells, Cultured; Conotoxins; Ethyl Methanesulfonate; Ion Channel Gating; Lidocaine; Mesylates; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Rats; Saxitoxin; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship; Tetrodotoxin; Transfection; Xenopus laevis | 2001 |
Time course and effective spread of lidocaine and tetrodotoxin delivered via microdialysis: an electrophysiological study in cerebral cortex.
Topics: Anesthetics, Local; Animals; Axons; Drug Delivery Systems; Evoked Potentials, Somatosensory; Female; Lidocaine; Male; Microdialysis; Raccoons; Somatosensory Cortex; Tetrodotoxin; Time Factors | 2001 |
Ion channels associated with the ectopic discharges generated after segmental spinal nerve injury in the rat.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cadmium; Calcium Channel Blockers; Calcium Channels; Cobalt; Ion Channels; Ion Transport; Lidocaine; Ligation; Male; Nerve Fibers; Nerve Tissue Proteins; Neurons, Afferent; Neurotoxins; Potassium Channels; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Spinal Nerves; Synaptic Transmission; Tetrodotoxin | 2001 |
Choline blocks AMPA-induced dark cell degeneration of Purkinje neurons: potential role of the alpha7 nicotinic receptor.
Topics: Aconitine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha7 Nicotinic Acetylcholine Receptor; Animals; Choline; Excitatory Amino Acid Agonists; Extracellular Space; Female; Gluconates; Insecticides; Lidocaine; Male; Meglumine; Nerve Degeneration; Neurotoxins; Nicotine; Nootropic Agents; Organ Culture Techniques; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Nicotinic; Sodium; Sodium Channels; Sodium Chloride; Tetrodotoxin | 2001 |
Differences between nerve terminal impulses of polymodal nociceptors and cold sensory receptors of the guinea-pig cornea.
Topics: Action Potentials; Anesthetics, Local; Animals; Cold Temperature; Cornea; Evoked Potentials; Guinea Pigs; Lidocaine; Nociceptors; Presynaptic Terminals; Tetrodotoxin; Thermoreceptors | 2001 |
Ionic mechanisms underlying burst firing of layer III sensorimotor cortical neurons of the cat: an in vitro slice study.
Topics: Action Potentials; Anesthetics, Local; Animals; Apamin; Calcium; Calcium Channel Blockers; Cats; Chelating Agents; Egtazic Acid; Electrophysiology; Lidocaine; Manganese; Motor Cortex; Neurons; Organ Culture Techniques; Periodicity; Sodium; Somatosensory Cortex; Tetraethylammonium; Tetrodotoxin | 2001 |
Function of NMDA receptors and persistent sodium channels in a feedback pathway of the electrosensory system.
Topics: Anesthetics, Local; Animals; Antibodies; Brain Chemistry; Electric Fish; Electric Organ; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback; GABA Antagonists; Immunoblotting; Immunohistochemistry; Lidocaine; Piperazines; Pyramidal Cells; Pyridazines; Rabbits; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Tetrodotoxin | 2001 |
Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortex.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Cadmium; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Ion Channel Gating; Lidocaine; Male; Nickel; Organ Culture Techniques; Potassium Channel Blockers; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium Channels; Synapses; Tetraethylammonium; Tetrodotoxin | 2001 |
Lithium increases potency of lidocaine-induced block of voltage-gated Na+ currents in rat sensory neurons in vitro.
Topics: Animals; Anti-Arrhythmia Agents; Cells, Cultured; Drug Synergism; Electric Stimulation; Electrophysiology; Ion Channel Gating; Lidocaine; Lithium; Neurons, Afferent; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin | 2001 |
Sodium influx blockade and hypoxic damage to CA1 pyramidal neurons in rat hippocampal slices.
Topics: Adenosine Triphosphate; Anesthetics, Local; Animals; Calcium; Cytosol; Electrophysiology; Hippocampus; Hypoxia; Lidocaine; Male; Membrane Potentials; Nerve Tissue Proteins; Patch-Clamp Techniques; Potassium; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Tetrodotoxin | 2001 |
Sodium current in human jejunal circular smooth muscle cells.
Topics: Anesthetics, Local; Calcium Channel Blockers; Calcium Channels, L-Type; Humans; Jejunum; Kinetics; Lidocaine; Membrane Potentials; Molecular Sequence Data; Muscle, Smooth; NAV1.5 Voltage-Gated Sodium Channel; Nifedipine; Patch-Clamp Techniques; RNA, Messenger; Sequence Homology, Amino Acid; Sodium; Sodium Channels; Tetrodotoxin | 2002 |
Actions of Androctonus australis and Leiurus quinquestriatus venoms in the rat isolated atria and anesthetized rats; effect of magnesium and lidocaine.
Topics: Action Potentials; Animals; Atrial Function; Drug Interactions; Heart Atria; Hemodynamics; In Vitro Techniques; Lidocaine; Magnesium; Muscle Contraction; Nerve Block; Rats; Rats, Wistar; Ryanodine; Scorpion Venoms; Scorpions; Tetrodotoxin; Torsades de Pointes | 2002 |
Differential sensitivity to tetrodotoxin and lack of effect of prostaglandin E2 on the pharmacology and physiology of propagated action potentials.
Topics: Action Potentials; Anesthetics, Local; Animals; Dinoprostone; Electric Stimulation; Female; In Vitro Techniques; Lidocaine; Male; Oxytocics; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Vagus Nerve; Veratridine | 2002 |
Effect of veratrine alkaloids on the efflux of extra-granular noradrenaline from rabbit atria.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Arrhythmia Agents; Biological Transport; Catechol O-Methyltransferase Inhibitors; Cocaine; Colchicine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Atria; In Vitro Techniques; Lidocaine; Male; Monoamine Oxidase Inhibitors; Neurons; Norepinephrine; Rabbits; Reserpine; Tetrodotoxin; Veratrine | 1976 |
Distally directed dendrotoxicity induced by kainic Acid in hippocampal interneurons of green fluorescent protein-expressing transgenic mice.
Topics: Animals; Biolistics; Calcium Channel Blockers; Dendrites; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Interneurons; Iontophoresis; Kainic Acid; Lidocaine; Luminescent Proteins; Mice; Mice, Transgenic; Neural Inhibition; Pyramidal Cells; Receptors, AMPA; Sodium Channel Blockers; Sodium Channels; Somatostatin; Tetrodotoxin; Transfection | 2002 |
Micromolar lidocaine selectively blocks propagating ectopic impulses at a distance from their site of origin.
Topics: 4-Aminopyridine; Action Potentials; Anesthetics, Local; Animals; Cnidarian Venoms; Electric Stimulation; Lidocaine; Potassium Channel Blockers; Rana catesbeiana; Rana pipiens; Sciatica; Tetrodotoxin | 2002 |
The origin of the 900 Hz spectral peak in spontaneous and sound-evoked round-window electrical activity.
Topics: Action Potentials; Anesthetics, Local; Animals; Cerebellum; Cochlear Nerve; Cochlear Nucleus; Electrophysiology; Guinea Pigs; Hair Cells, Auditory; Lidocaine; Oscillometry; Round Window, Ear; Sound; Tetrodotoxin | 2002 |
Role of voltage-gated cation channels and axon reflexes in the release of sensory neuropeptides by capsaicin from isolated rat trachea.
Topics: Agatoxins; Anesthetics, Local; Animals; Axons; Cadmium; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Calcium Channels; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Female; In Vitro Techniques; Lidocaine; Male; Neuropeptides; omega-Conotoxin GVIA; Rats; Reflex; Sodium Channels; Somatostatin; Spider Venoms; Substance P; Tetrodotoxin; Trachea | 2003 |
Patch-clamp analysis in canine cardiac Purkinje cells of a novel sodium component in the pacemaker range.
Topics: Algorithms; Anesthetics, Local; Animals; Barium; Biological Clocks; Cesium; Dogs; Electrophysiology; Female; Heart; In Vitro Techniques; Ion Channel Gating; Lidocaine; Male; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Purkinje Fibers; Sodium; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2003 |
A mechanical stretch induces contractile activation in unstimulated developing rat skeletal muscle in vitro.
Topics: Aging; Animals; Animals, Newborn; Butylene Glycols; Calcium; In Vitro Techniques; Intracellular Membranes; Lidocaine; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Osmolar Concentration; Potassium; Rats; Rest; Sarcomeres; Stress, Mechanical; Tetrodotoxin; Time Factors | 2003 |
ELECTRICAL ACTIVITY IN THE CHEMORECEPTORS OF THE BLOWFLY. 3. DENDRITIC ACTION POTENTIALS.
Topics: Action Potentials; Animals; Chemoreceptor Cells; Chloral Hydrate; Cocaine; Dendrites; Diptera; Electrophysiology; Lidocaine; Neurons; Pharmacology; Procaine; Research; Sensory Receptor Cells; Sodium Chloride; Tetrodotoxin | 1965 |
Lidocaine and octanol have different modes of action at tetrodotoxin-resistant Na(+) channels of peripheral nerves.
Topics: 1-Octanol; Algorithms; Anesthetics, Local; Animals; Electrophysiology; Female; Ganglia, Spinal; Kinetics; Lidocaine; Male; Neurons; Patch-Clamp Techniques; Peripheral Nerves; Rats; Rats, Wistar; Sodium Channels; Tetrodotoxin | 2003 |
A novel mutation in SCN5A, delQKP 1507-1509, causing long QT syndrome: role of Q1507 residue in sodium channel inactivation.
Topics: Adult; Base Sequence; Cell Line; Child; Chromatography, High Pressure Liquid; DNA Mutational Analysis; Female; Genetic Testing; Heterozygote; Humans; Lidocaine; Long QT Syndrome; Male; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Pedigree; Polymerase Chain Reaction; Sequence Deletion; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2003 |
Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amphetamines; Animals; Bicuculline; Fluorobenzenes; GABA-A Receptor Antagonists; Glutamic Acid; Indoles; Lidocaine; Male; Patch-Clamp Techniques; Phenols; Pindolol; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Sodium Channel Blockers; Sulfonamides; Synapses; Tetrodotoxin; Time Factors | 2004 |
Lidocaine increases phosphorylation of focal adhesion kinase in rat hippocampal slices.
Topics: Anesthetics, Local; Animals; Blotting, Western; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hippocampus; In Vitro Techniques; Lidocaine; Male; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ryanodine Receptor Calcium Release Channel; Stimulation, Chemical; Tetrodotoxin; Tyrosine | 2004 |
Voltage-dependent enhancement of electrical coupling by a subthreshold sodium current.
Topics: Animals; Auditory Pathways; Escape Reaction; Evoked Potentials; Goldfish; Lidocaine; Models, Neurological; Neurons; Potassium Channel Blockers; Presynaptic Terminals; Sodium Channel Blockers; Sodium Channels; Synaptic Transmission; Tetrodotoxin; Vestibulocochlear Nerve | 2004 |
Lidocaine increases intracellular sodium concentration through voltage-dependent sodium channels in an identified lymnaea neuron.
Topics: Anesthetics, Local; Animals; Benzofurans; Calibration; Diagnostic Imaging; Electrophysiology; Ethers, Cyclic; Fluorescent Dyes; In Vitro Techniques; Ion Channel Gating; Lidocaine; Lymnaea; Membrane Potentials; Microelectrodes; Neurons; Patch-Clamp Techniques; Sodium; Sodium Channels; Tetrodotoxin | 2004 |
Evaluation of the rat bladder-derived relaxant factor by coaxial bioassay system.
Topics: Acetylcholine; Animals; Biological Assay; Biological Factors; Bupivacaine; Dose-Response Relationship, Drug; Hydrogen Peroxide; Hydrogen-Ion Concentration; In Vitro Techniques; Lidocaine; Male; Muscle Proteins; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Papaverine; Phenylephrine; Procaine; Pyrogallol; Rats; Rats, Wistar; Reactive Oxygen Species; Tetrodotoxin; Urinary Bladder; Urothelium | 2004 |
The effects of class Ic antiarrhythmics on tetrodotoxin-resistant Na+ currents in rat sensory neurons.
Topics: Algorithms; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Drug Interactions; Drug Resistance; Flecainide; Ganglia, Spinal; Lidocaine; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2004 |
Presynaptic activity and Ca2+ entry are required for the maintenance of NMDA receptor-independent LTP at visual cortical excitatory synapses.
Topics: Anesthetics, Local; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, P-Type; Electric Stimulation; Excitatory Postsynaptic Potentials; Lidocaine; Long-Term Potentiation; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin; Visual Cortex | 2004 |
A novel SCN5A mutation manifests as a malignant form of long QT syndrome with perinatal onset of tachycardia/bradycardia.
Topics: Bradycardia; Cell Line; DNA Mutational Analysis; Female; Humans; Infant, Newborn; Lidocaine; Long QT Syndrome; Male; Mutation; Myocardium; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Sequence Analysis, DNA; Sodium Channels; Tachycardia, Ventricular; Tetrodotoxin; Transfection | 2004 |
Sodium channels in transient retinal bipolar cells enhance visual responses in ganglion cells.
Topics: Ambystoma; Animals; Choline; Dendrites; Interneurons; Ion Channel Gating; Larva; Lidocaine; Patch-Clamp Techniques; Photic Stimulation; Photoreceptor Cells, Vertebrate; Retinal Ganglion Cells; Sodium; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Time Factors; Visual Pathways | 2005 |
Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue.
Topics: Animals; Cadmium; Cell Line; Extracellular Fluid; Ganglia, Spinal; Humans; Intracellular Fluid; Lidocaine; Male; Neurons, Afferent; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Saxitoxin; Serine; Sodium; Sodium Channels; Tetrodotoxin | 2005 |
Cocaine-induced modulation of long-term potentiation in the CA1 region of rat hippocampus.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Benzazepines; Cocaine; Desipramine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Fluoxetine; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Neurotransmitter Uptake Inhibitors; Piperazines; Propranolol; Rats; Rats, Sprague-Dawley; Salicylamides; Tetrodotoxin | 2005 |
Nerve growth factor-induced hyperexcitability of rat sensory neuron in culture.
Topics: Action Potentials; Anesthetics, Local; Animals; In Vitro Techniques; Lidocaine; Male; Nerve Growth Factor; Neurons, Afferent; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Time Factors | 2005 |
The pentapeptide QYNAD does not inhibit neuronal network activity.
Topics: Animals; Biosensing Techniques; Cerebral Cortex; Lidocaine; Microelectrodes; Nerve Net; Neurons; Oligopeptides; Rats; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2005 |
Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.
Topics: Ambroxol; Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Benzocaine; Drug Resistance; Lidocaine; Mexiletine; NAV1.2 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neurons, Afferent; Patch-Clamp Techniques; Rats; Recombinant Proteins; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2006 |
Evidence for a multivalent interaction of symmetrical, N-linked, lidocaine dimers with voltage-gated Na+ channels.
Topics: Anesthetics, Local; Animals; Biological Assay; Cell Membrane; Cells, Cultured; Dimerization; Ganglia, Spinal; Humans; Lidocaine; Membrane Potentials; Rats; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2006 |
Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.
Topics: Animals; Benzothiazoles; Bradycardia; Heart Atria; Heart Rate; Lidocaine; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sinoatrial Node; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Thiadiazoles; Thiazoles | 2006 |
NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Genes, Reporter; Glutamic Acid; Lac Operon; Lidocaine; Magnesium; Membrane Potentials; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Promoter Regions, Genetic; Protein Subunits; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Somatosensory Cortex; Synapses; Synaptic Transmission; Tetrodotoxin | 2006 |
Influence of D-arabitol and ribitol on neuronal network activity.
Topics: Animals; Brain; Carbohydrate Metabolism; Cryopreservation; Dose-Response Relationship, Drug; Electrophysiology; Humans; Lidocaine; Nerve Net; Neurons; Rats; Ribitol; Sugar Alcohols; Tetrodotoxin | 2005 |
On the role of intramural nerves in the pathogenesis of cholera toxin-induced intestinal secretion.
Topics: Anesthetics, Local; Animals; Cats; Celiac Plexus; Cholera; Cholera Toxin; Disease Models, Animal; Female; Intestinal Secretions; Jejunum; Lidocaine; Male; Poisons; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1981 |
Luminal hypotonicity increases duodenal mucosal permeability by a mechanism involving 5-hydroxytryptamine.
Topics: Anesthetics, Local; Animals; Cyclooxygenase Inhibitors; Duodenum; Granisetron; Indoles; Indomethacin; Intestinal Mucosa; Lidocaine; Male; Ondansetron; Osmotic Pressure; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Agents; Serotonin Antagonists; Tetrodotoxin; Tropisetron | 2006 |
Phe-met-arg-phe (FMRF)-amide is a substrate source of NO synthase in the gastropod nervous system.
Topics: Amiloride; Animals; FMRFamide; Gastropoda; Immunohistochemistry; Lidocaine; Muscle Contraction; NADPH Dehydrogenase; Nervous System; Neuropeptides; Nitric Oxide Synthase; Sodium Channel Blockers; Tetrodotoxin | 2006 |
An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Animals, Newborn; Aspartic Acid; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Lidocaine; Magnesium; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetrodotoxin | 2006 |
Reversible inactivation of the dorsal hippocampus by tetrodotoxin or lidocaine: a comparative study on cerebral functional activity and motor coordination in the rat.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Autoradiography; Behavior, Animal; Cerebral Cortex; Deoxyglucose; Dose-Response Relationship, Drug; Functional Laterality; Glucose; Hippocampus; Lidocaine; Male; Maze Learning; Psychomotor Performance; Rats; Tetrodotoxin; Time Factors | 2006 |
Sodium-, chloride-, and mibefradil-sensitive calcium channels in intestinal pacing in wild-type and W/WV mice.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Chloride Channels; Gastrointestinal Motility; Intestinal Mucosa; Lidocaine; Male; Mibefradil; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscles; Sodium; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2006 |
The effect of dibutyryl cAMP on tetrodotoxin-sensitive and -resistant voltage-gated sodium currents in rat dorsal root ganglion neurons and the consequences for their sensitivity to lidocaine.
Topics: Algorithms; Anesthetics, Local; Animals; Bucladesine; Data Interpretation, Statistical; Electrophysiology; Female; Ganglia, Spinal; In Vitro Techniques; Ion Channel Gating; Kinetics; Lidocaine; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2006 |
Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels.
Topics: Amitriptyline; Animals; Cell Line; Dose-Response Relationship, Drug; Lidocaine; Mice; Mice, Inbred C57BL; NAV1.8 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Protein Subunits; Rats; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2007 |
A slowly inactivating sodium current (INa2) in the plateau range in canine cardiac Purkinje single cells.
Topics: Action Potentials; Animals; Cadmium; Dogs; Heart Conduction System; In Vitro Techniques; Ion Channel Gating; Kinetics; Lidocaine; Manganese; Patch-Clamp Techniques; Purkinje Fibers; Sodium; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2007 |
Non-Gaussian membrane potential dynamics imply sparse, synchronous activity in auditory cortex.
Topics: Acoustic Stimulation; Anesthetics, Local; Animals; Animals, Newborn; Auditory Cortex; Cortical Synchronization; Electric Stimulation; Lidocaine; Membrane Potentials; Models, Neurological; Neural Inhibition; Neurons; Nonlinear Dynamics; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Time Factors; Wakefulness | 2006 |
Involvement of persistent Na+ current in spike initiation in primary sensory neurons of the rat mesencephalic trigeminal nucleus.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Lidocaine; Neurons, Afferent; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Riluzole; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Trigeminal Nuclei | 2007 |
Quantification of zinc toxicity using neuronal networks on microelectrode arrays.
Topics: Anesthetics, Local; Animals; Bicuculline; Cell Size; Cells, Cultured; Data Interpretation, Statistical; Electrophysiology; GABA Antagonists; Lidocaine; Mice; Mice, Inbred BALB C; Microelectrodes; Nerve Net; Neuroglia; Neurons; Tetrodotoxin; Zinc | 2007 |
Effects of ifenprodil on voltage-gated tetrodotoxin-resistant Na+ channels in rat sensory neurons.
Topics: Adrenergic alpha-Antagonists; Analgesics; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Ganglia, Spinal; Ion Channel Gating; Ketamine; Lidocaine; Male; Membrane Potentials; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin | 2007 |
Lidocaine promotes the trafficking and functional expression of Na(v)1.8 sodium channels in mammalian cells.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Calnexin; Cells, Cultured; Dose-Response Relationship, Radiation; Electric Stimulation; Endoplasmic Reticulum; Ganglia, Spinal; Gene Expression Regulation; Humans; Immunohistochemistry; Lidocaine; Microscopy, Confocal; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Protein Transport; Rats; Sodium Channels; Tetrodotoxin; Transfection | 2007 |
Effects of alpha2-adrenoceptor agonists on tetrodotoxin-resistant Na+ channels in rat dorsal root ganglion neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Algorithms; Anesthetics, Local; Animals; Clonidine; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Resistance; Ganglia, Spinal; Lidocaine; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Yohimbine | 2007 |
Pharmacological manipulation of neuronal ensemble activity by reverse microdialysis in freely moving rats: a comparative study of the effects of tetrodotoxin, lidocaine, and muscimol.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Lidocaine; Male; Microdialysis; Models, Animal; Muscimol; Neurons; Neurotransmitter Agents; Rats; Rats, Wistar; Tetrodotoxin | 2007 |
Lidocaine suppresses subthreshold oscillations by inhibiting persistent Na(+) current in injured dorsal root ganglion neurons.
Topics: Anesthetics, Local; Animals; Data Interpretation, Statistical; Electrophysiology; Female; Ganglia, Spinal; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2008 |
Pharmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo.
Topics: Anesthetics, Local; Animals; Atropine; Chlorides; Colon; Duodenum; Enzyme Inhibitors; Ganglionic Blockers; Granisetron; Hexamethonium; Hormone Antagonists; Injections, Intravenous; Intestinal Secretions; Lidocaine; Male; Mechanotransduction, Cellular; Membrane Potentials; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Nitroarginine; Peripheral Nervous System Agents; Piperidines; Pressure; Quinolines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Receptors, Serotonin, 5-HT3; Receptors, Vasoactive Intestinal Peptide; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Tetrodotoxin; Time Factors; Vasoactive Intestinal Peptide | 2008 |
Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges.
Topics: Animals; Carbamazepine; Cyanides; Enzyme Inhibitors; Female; Lidocaine; Lithium; Male; Meninges; Nerve Fibers, Unmyelinated; Neural Conduction; Neurons, Afferent; Ouabain; Potassium; Rats; Rats, Wistar; Sodium; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Synaptic Transmission; Tetrodotoxin | 2008 |
Inhibition of toll-like receptor-4, nuclear factor-kappaB and mitogen-activated protein kinase by lignocaine may involve voltage-sensitive sodium channels.
Topics: Anesthetics, Local; Animals; Cells, Cultured; Enzyme Activation; Lidocaine; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Sodium Channels; Tetrodotoxin; Toll-Like Receptor 4 | 2008 |
Differential interactions of Na+ channel toxins with T-type Ca2+ channels.
Topics: Amino Acid Sequence; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cell Line; Cells, Cultured; Dogs; Drug Interactions; Humans; Lidocaine; Marine Toxins; Membrane Potentials; Mibefradil; Molecular Sequence Data; Myocytes, Cardiac; Nickel; Saxitoxin; Sequence Homology, Amino Acid; Sodium Channel Blockers; Tetrodotoxin; Transfection | 2008 |
Access and binding of local anesthetics in the closed sodium channel.
Topics: Anesthetics, Local; Binding Sites; Cocaine; Computer Simulation; Conotoxins; Lidocaine; Ligands; Models, Biological; Models, Molecular; Molecular Structure; Monte Carlo Method; Mutation; Protein Conformation; Sodium; Sodium Channels; Static Electricity; Tetracaine; Tetrodotoxin; Water | 2008 |
Postsynaptic action potentials are required for nitric-oxide-dependent long-term potentiation in CA1 neurons of adult GluR1 knock-out and wild-type mice.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Biophysics; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitroarginine; Receptors, AMPA; Synaptic Potentials; Tetrodotoxin | 2008 |
Functional tetrodotoxin-resistant Na(+) channels are expressed presynaptically in rat dorsal root ganglia neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Benzofurans; Biophysics; Calcium; Cells, Cultured; Coculture Techniques; Disks Large Homolog 4 Protein; Electric Stimulation; Ethers, Cyclic; Extracellular Fluid; Ganglia, Spinal; Intracellular Signaling Peptides and Proteins; Ion Channel Gating; Lidocaine; Membrane Proteins; NAV1.8 Voltage-Gated Sodium Channel; NAV1.9 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neuropeptides; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sodium; Sodium Channel Blockers; Sodium Channels; Spinal Cord; Synapses; Tetrodotoxin | 2009 |
Homeostatic presynaptic suppression of neuronal network bursts.
Topics: Action Potentials; Anesthetics, Local; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; Green Fluorescent Proteins; Hippocampus; Inhibitory Postsynaptic Potentials; Lidocaine; N-Methylaspartate; Nerve Net; Neurons; Presynaptic Terminals; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptosomal-Associated Protein 25; Tetrodotoxin; Time Factors; Transfection; Valine; Vesicle-Associated Membrane Protein 2 | 2009 |
Lidocaine, tetrodotoxin and their effect on consolidation of spatial memory.
Topics: Animals; Lidocaine; Male; Memory; Memory Disorders; Rats; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin | 2009 |
Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury.
Topics: Adrenergic alpha-Agonists; Animals; Astrocytes; Citrates; Clonidine; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Hyperalgesia; Lidocaine; Male; Median Neuropathy; Medulla Oblongata; Pain Threshold; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin; Time Factors; Up-Regulation | 2010 |
The tetrodotoxin-resistant Na+ channel Na (v)1.8 reduces the potency of local anesthetics in blocking C-fiber nociceptors.
Topics: Anesthetics, Local; Animals; Lidocaine; Mice; Mice, Inbred C57BL; Mice, Knockout; NAV1.8 Voltage-Gated Sodium Channel; Nociceptors; Sodium Channels; Tetrodotoxin | 2010 |
Membrane properties of neuron-like cells generated from adult human bone-marrow-derived mesenchymal stem cells.
Topics: Action Potentials; Biomarkers; Bone Marrow Cells; Calcium; Calcium Channels; Humans; Lidocaine; Membranes; Mesenchymal Stem Cells; Neural Stem Cells; Neurons; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Potassium Chloride; Receptors, Glutamate; Sodium Channels; Tetrodotoxin | 2010 |
Spinal cord injury immediately changes the state of the brain.
Topics: Afferent Pathways; Analysis of Variance; Animals; Biophysics; Disease Models, Animal; Electric Stimulation; Electroencephalography; Evoked Potentials, Somatosensory; Lidocaine; Lower Extremity; Male; Rats; Rats, Wistar; Sodium Channel Blockers; Somatosensory Cortex; Spinal Cord Injuries; Statistics as Topic; Tetrodotoxin | 2010 |
Lidocaine reduces the transition to slow inactivation in Na(v)1.7 voltage-gated sodium channels.
Topics: Action Potentials; Anesthetics, Local; Cells, Cultured; HEK293 Cells; Humans; Lidocaine; Mutation; NAV1.7 Voltage-Gated Sodium Channel; Neurons; Pain; Patch-Clamp Techniques; Sodium Channels; Tetrodotoxin | 2011 |
The extract of the jellyfish Phyllorhiza punctata promotes neurotoxic effects.
Topics: Animals; Chickens; Cnidarian Venoms; Lidocaine; Male; Marine Toxins; Mice; Neuromuscular Junction; Oxocins; Phentolamine; Phospholipases A2; Saxitoxin; Scyphozoa; Specimen Handling; Synaptic Transmission; Tetrodotoxin; Vas Deferens | 2011 |
Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmission.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Lidocaine; Male; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Polyamines; Receptors, AMPA; Tetrodotoxin; Valine | 2011 |
Dexmedetomidine and clonidine inhibit the function of Na(v)1.7 independent of α(2)-adrenoceptor in adrenal chromaffin cells.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding Sites; Cattle; Cells, Cultured; Chromaffin Cells; Clonidine; Cyclopentanes; Dexmedetomidine; Imidazoles; Lidocaine; Organophosphorus Compounds; Ouabain; Pain; Receptors, Adrenergic, alpha-2; Scorpion Venoms; Sodium; Sodium Channels; Tetrodotoxin; Veratridine; Yohimbine | 2011 |
Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.
Topics: Adaptation, Physiological; Animals; Animals, Newborn; Axons; Cell Adhesion Molecules; Cells, Cultured; Coculture Techniques; Collagen Type VII; Epidermolysis Bullosa, Junctional; Ganglia, Spinal; Growth Cones; Humans; Kalinin; Keratinocytes; Lidocaine; Mechanotransduction, Cellular; Membrane Potentials; Mice; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Neurofilament Proteins; Patch-Clamp Techniques; Physical Stimulation; Reaction Time; Sensory Receptor Cells; Skin; Sodium Channel Blockers; Tetrodotoxin; Time Factors; TRPV Cation Channels; Ubiquitin Thiolesterase | 2011 |
A sodium channel blocker, pilsicainide, produces atrial post-repolarization refractoriness through the reduction of sodium channel availability.
Topics: Action Potentials; Animals; Guinea Pigs; Heart Atria; In Vitro Techniques; Kinetics; Lidocaine; Male; Refractory Period, Electrophysiological; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2011 |
Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus.
Topics: Acoustic Stimulation; Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Auditory Pathways; Biophysics; Calcium; Calcium Channel Blockers; Cyclic Nucleotide-Gated Cation Channels; Electric Stimulation; Female; Gene Expression Regulation, Developmental; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Lidocaine; Mibefradil; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nerve Net; Neural Inhibition; Neurons; Olivary Nucleus; Periodicity; Potassium Channels; Psychoacoustics; Pyrimidines; Reaction Time; Sound; Tetrodotoxin | 2011 |
Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Anesthetics, Local; Animals; Animals, Newborn; Biophysics; CA1 Region, Hippocampal; Corpus Striatum; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Interneurons; Lidocaine; Male; Neural Pathways; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium Channel Blockers; Synapses; Synaptic Potentials; Tetrodotoxin | 2012 |
Local anesthetic-like inhibition of voltage-gated Na(+) channels by the partial μ-opioid receptor agonist buprenorphine.
Topics: Action Potentials; Anesthetics, Local; Animals; Buprenorphine; Cell Line; Data Interpretation, Statistical; Ganglia, Spinal; Humans; Lidocaine; Mice; Mice, Inbred C57BL; Narcotics; NAV1.4 Voltage-Gated Sodium Channel; Nerve Fibers; Nerve Fibers, Unmyelinated; Patch-Clamp Techniques; Receptors, Opioid, mu; Skin; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2012 |
Antimetastatic potential of amide-linked local anesthetics: inhibition of lung adenocarcinoma cell migration and inflammatory Src signaling independent of sodium channel blockade.
Topics: Adenocarcinoma; Amides; Anesthetics, Local; Cell Line, Tumor; Cell Movement; Humans; Intercellular Adhesion Molecule-1; Lidocaine; Lung Neoplasms; Neoplasm Metastasis; Phosphorylation; Procaine; Retrospective Studies; Ropivacaine; Signal Transduction; Sodium Channel Blockers; src-Family Kinases; Tetrodotoxin; Veratridine | 2012 |
Early development of electrical excitability in the mouse enteric nervous system.
Topics: Action Potentials; Age Factors; Anesthetics, Local; Animals; Animals, Newborn; Biophysical Phenomena; Biophysics; Electric Stimulation; Embryo, Mammalian; Enteric Nervous System; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Lidocaine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Sodium Channels; Statistics, Nonparametric; Tetrodotoxin; Tyrosine 3-Monooxygenase | 2012 |
Thrombin facilitates seizures through activation of persistent sodium current.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Animals, Newborn; Biophysics; Convulsants; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Ion Channel Gating; Lidocaine; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Thrombin; Valine | 2012 |
Human pluripotent stem cell-derived cardiomyocytes: response to TTX and lidocain reveals strong cell to cell variability.
Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Cell Differentiation; Cell Line; Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Ion Channels; Lidocaine; Muscarinic Agonists; Myocytes, Cardiac; Sodium Channel Blockers; Tetrodotoxin | 2012 |
Overinhibition of corticostriatal activity following prenatal cocaine exposure.
Topics: Age Factors; Analysis of Variance; Anesthetics, Local; Animals; Biophysics; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Female; GABA Agents; Green Fluorescent Proteins; Hindlimb Suspension; In Vitro Techniques; Interneurons; Lidocaine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neural Inhibition; Neuronal Plasticity; Patch-Clamp Techniques; Pregnancy; Prenatal Exposure Delayed Effects; Quinoxalines; Quinpirole; Receptors, GABA-A; Rotarod Performance Test; Sodium Channel Blockers; Statistics, Nonparametric; Tetrodotoxin | 2013 |
Antagonism of lidocaine inhibition by open-channel blockers that generate resurgent Na current.
Topics: Analysis of Variance; Animals; Animals, Newborn; Biophysical Phenomena; CA1 Region, Hippocampal; Cnidarian Venoms; Electric Stimulation; Female; In Vitro Techniques; Ion Channel Gating; Lidocaine; Male; Mice; Neurons; Patch-Clamp Techniques; Peptides; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Voltage-Gated Sodium Channel beta-4 Subunit; Voltage-Gated Sodium Channel Blockers | 2013 |
In vivo synaptic scaling is mediated by GluA2-lacking AMPA receptors in the embryonic spinal cord.
Topics: Anesthetics, Local; Animals; Biophysics; Chick Embryo; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation, Developmental; Lidocaine; Motor Neurons; Patch-Clamp Techniques; Pyridazines; Receptors, AMPA; Spinal Cord; Synapses; Tetrodotoxin | 2013 |
Neural origin of evoked potentials during thalamic deep brain stimulation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cats; Deep Brain Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA-A Receptor Agonists; Lidocaine; Male; Muscimol; Neurons; Sodium Channel Blockers; Tetrodotoxin; Thalamus; Valine | 2013 |
Chronic NGF treatment induces somatic hyperexcitability in cultured dorsal root ganglion neurons of the rat.
Topics: Action Potentials; Animals; Cations, Monovalent; Ganglia, Spinal; Lidocaine; Male; Nerve Growth Factor; Neurons; Patch-Clamp Techniques; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Sodium; Tetrodotoxin | 2013 |
[The involvement of lidocaine and tetrodotoxin-sensitive current in the generation of action potentials with low DV/DT max in the cells of the mouse sinoauricular region].
Topics: Action Potentials; Animals; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Lidocaine; Male; Mice; Microelectrodes; Sinoatrial Node; Tetrodotoxin; Tissue Culture Techniques; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels | 2013 |
Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.
Topics: Aniline Compounds; Animals; Biophysics; Cells, Cultured; Electric Stimulation; Furans; Ganglia, Spinal; Immunoprecipitation; Inflammation Mediators; Lidocaine; Membrane Potentials; NAV1.8 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Peptides; Protein Subunits; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sodium Channel Blockers; Tetrodotoxin | 2014 |
Impact of tetrodotoxin application and lidocaine supplementation on equine jejunal smooth muscle contractility and activity of the enteric nervous system in vitro.
Topics: Animals; Enteric Nervous System; Gastrointestinal Motility; Horses; Interstitial Cells of Cajal; Jejunum; Lidocaine; Muscle Contraction; Muscle, Smooth; Sodium Channel Blockers; Tetrodotoxin; Voltage-Gated Sodium Channel Blockers | 2014 |
Contribution of ion currents to beat-to-beat variability of action potential duration in canine ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Cardiotonic Agents; Cells, Cultured; Chromans; Dogs; Feedback, Physiological; Female; Heart Ventricles; Ion Channels; Ion Transport; Isoproterenol; Lidocaine; Male; Myocytes, Cardiac; Nisoldipine; Phenethylamines; Potassium Channel Blockers; Sulfonamides; Tetrodotoxin; Veratridine | 2015 |
Characterisation of the contractile dynamics of the resting ex vivo urinary bladder of the pig.
Topics: Animals; Female; Image Processing, Computer-Assisted; Lidocaine; Muscarine; Muscle Contraction; Muscle, Smooth; Pressure; Sus scrofa; Swine; Tetrodotoxin; Urinary Bladder; Video Recording | 2015 |
Pulsed magnetic stimulation modifies amplitude of action potentials in vitro via ionic channels-dependent mechanism.
Topics: Action Potentials; Animals; Ascorbic Acid; Cyclic AMP-Dependent Protein Kinases; Female; Free Radical Scavengers; Lidocaine; Magnetic Fields; Male; Mice; Microelectrodes; Potassium; Protein Kinase C; Sciatic Nerve; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Veratridine; Vitamin E | 2015 |
Topical Tetrodotoxin Attenuates Photophobia Induced by Corneal Injury in the Rat.
Topics: Administration, Topical; Analysis of Variance; Anesthetics, Local; Animals; Corneal Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Lidocaine; Male; Photic Stimulation; Photophobia; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Time Factors | 2015 |
Comparative evaluation of in vitro and in vivo high glucose-induced alterations in voltage-gated tetrodotoxin-resistant sodium channel: Effects attenuated by sodium channel blockers.
Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Interactions; Ganglia, Spinal; Glucose; Lidocaine; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Streptozocin; Sweetening Agents; Tetrodotoxin; Voltage-Gated Sodium Channels | 2015 |
Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Ciguatera Poisoning; Ciguatoxins; Enzyme-Linked Immunosorbent Assay; Humans; Hyperalgesia; Lidocaine; Male; Marine Toxins; Membrane Potentials; Mice; Mice, Transgenic; NAV1.1 Voltage-Gated Sodium Channel; NAV1.7 Voltage-Gated Sodium Channel; NAV1.9 Voltage-Gated Sodium Channel; Rats; Receptors, Calcitonin Gene-Related Peptide; Tetrodotoxin | 2017 |
Bimodal Electrical Properties of Rat Major Artery Segment In Situ.
Topics: Anesthetics, Local; Animals; Animals, Outbred Strains; Blood Pressure; Electric Impedance; Electrodes; Femoral Artery; Lidocaine; Male; Procaine; Pulse; Rats; Sodium Channel Blockers; Tetrodotoxin; Tissue Culture Techniques | 2018 |
Calcimimetic acts on enteric neuronal CaSR to reverse cholera toxin-induced intestinal electrolyte secretion.
Topics: Animals; Cell Communication; Cholera Toxin; Colon; Electrolytes; Enteric Nervous System; Evoked Potentials; Female; Intestinal Mucosa; Lidocaine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenethylamines; Propylamines; Receptors, Calcium-Sensing; Tetrodotoxin | 2018 |
Involvement of the persistent Na
Topics: Action Potentials; Animals; Atrial Fibrillation; Cells, Cultured; Diastole; Guinea Pigs; Lidocaine; Male; Membrane Potentials; Myocytes, Cardiac; Pulmonary Veins; Pyridines; Sodium; Tetrodotoxin; Triazoles | 2019 |
Combination Formulation of Tetrodotoxin and Lidocaine as a Potential Therapy for Severe Arrhythmias.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Drug Combinations; Drug Stability; Excipients; Female; Freeze Drying; Lidocaine; Male; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Voltage-Gated Sodium Channel Blockers | 2019 |
Mixture effects of tetrodotoxin (TTX) and drugs targeting voltage-gated sodium channels on spontaneous neuronal activity in vitro.
Topics: Animals; Carbamazepine; Flecainide; Humans; Lidocaine; Rats; Riluzole; Tetrodotoxin; Voltage-Gated Sodium Channels | 2023 |