lidocaine has been researched along with tacrine in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (21.21) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 11 (33.33) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Bard, B; Carrupt, PA; Martel, S | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Bajda, M; Brus, B; Gobec, S; Guzior, N; Malawska, B; Rakoczy, J | 1 |
| Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K | 1 |
| Bienkowski, P; Bucki, A; Gobec, S; Godyń, J; Głuch-Lutwin, M; Kazek, G; Knez, D; Kołaczkowski, M; Malawska, B; Marcinkowska, M; Mierzejewski, P; Sienkiewicz-Jarosz, H; Siwek, A; Wichur, T; Więckowska, A; Więckowski, K; Zaręba, P | 1 |
| Brazzolotto, X; Brus, B; Colletier, JP; Coquelle, N; Gobec, S; Knez, D; Kos, J; Košak, U; Nachon, F; Pišlar, A | 1 |
| Dikshit, M; Srimal, RC | 1 |
| Asthana, OP; Dhawan, BN; Goel, R; Gupta, PP; Shukla, KN | 1 |
| Dasgupta, D; Paul, T; Satoskar, RS; Tendulkar, BA | 1 |
| Parikh, N; Paul, T; Satoskar, RS; Vacharajani, GN | 1 |
| Bhalerao, RA; Mody, BB; Paul, T; Samsi, AB; Satoskar, RS; Shah, SC | 1 |
| Dasgupta, D; Garasia, M; Gupta, KC; Satoskar, RS | 1 |
| Anand, N; Dhawan, BN; Patnaik, GK; Rastogi, SN | 1 |
| Dhawan, BN; Patnaik, GK | 1 |
| Beri, S; Biswas, NR; Das, GK; Ghose, S; Pandey, RM; Shende, DR | 1 |
| Aura, J; Ikonen, S; Riekkinen, M; Riekkinen, P | 1 |
| Beri, S; Biswas, NR; Das, GK; Ghose, S; Pandey, RM; Verma, B | 1 |
| Biswas, NR; Das, GK; Ghose, S; Jhingan, S; Pandey, RM; Sethi, A; Verma, B | 1 |
| Assini, FL; Duzzioni, M; Takahashi, RN | 1 |
| Gune, NS; Katre, AN | 1 |
| Kalra, G; Mathur, VP | 1 |
8 trial(s) available for lidocaine and tacrine
| Article | Year |
|---|---|
Clinical evaluation of centbucridine in ophthalmic surgery.
Topics: Adolescent; Adult; Aged; Aminoacridines; Anesthetics, Local; Double-Blind Method; Eye Diseases; Female; Humans; Lidocaine; Male; Middle Aged; Tacrine | 1985 |
Comparative study of centbucridine and lignocaine for subarachnoid block.
Topics: Adolescent; Adult; Aminoacridines; Anesthesia, Spinal; Anesthetics, Local; Clinical Trials as Topic; Double-Blind Method; Humans; Lidocaine; Middle Aged; Random Allocation; Subarachnoid Space; Tacrine | 1984 |
A comparative study of centbucridine and lidocaine in dental extraction.
Topics: Adolescent; Adult; Aminoacridines; Anesthesia, Dental; Anesthetics, Local; Blood Pressure; Female; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Tacrine; Tooth Extraction | 1983 |
Randomised double-blind study of centbucridine and lignocaine for subarachnoid block.
Topics: Acridines; Adolescent; Adult; Aged; Anesthesia, Spinal; Double-Blind Method; Humans; Lidocaine; Male; Middle Aged; Random Allocation; Spinal Nerves; Subarachnoid Space; Tacrine | 1983 |
Injectable centbucridine and lidocaine hydrochloride for intraocular surgery.
Topics: Aged; Anesthesia, Local; Anesthetics, Local; Cataract Extraction; Double-Blind Method; Facial Nerve; Female; Humans; Injections; Lidocaine; Male; Middle Aged; Nerve Block; Prospective Studies; Tacrine; Treatment Outcome | 1997 |
Centbucridine, a newer topical anaesthetic compared with lignocaine: a randomized double masked single drop instillation clinical trial.
Topics: Administration, Topical; Adult; Analysis of Variance; Anesthetics, Local; Double-Blind Method; Eye; Female; Humans; Lidocaine; Male; Middle Aged; Ophthalmic Solutions; Tacrine | 2003 |
A prospective randomized double masked controlled clinical trial to determine the efficacy of multiple drop centbucridine as an ocular surface anaesthetic.
Topics: Anesthetics, Local; Double-Blind Method; Humans; Lidocaine; Ophthalmologic Surgical Procedures; Prospective Studies; Tacrine | 2004 |
Comparison of 0.5% Centbucridine and 2% Lignocaine as Local Anesthetic Agents for Dental Procedures in Children: A Randomised Controlled Trial.
Topics: Anesthesia, Local; Anesthetics, Local; Child; Dentistry; Humans; Lidocaine; Nerve Block; Tacrine | 2020 |
25 other study(ies) available for lidocaine and tacrine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Identification and prediction of promiscuous aggregating inhibitors among known drugs.
Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Drug Delivery Systems; Drug Design; Drug Evaluation, Preclinical; Horses; Humans; Indoles; Protein Structure, Secondary | 2015 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Humans; Indans; Indoles; Male; Memory; Mice; Models, Molecular; Neuroprotective Agents; Phthalimides; Piperidines; Protein Aggregates; Scopolamine; Structure-Activity Relationship | 2015 |
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Ligands; Male; Models, Molecular; Molecular Targeted Therapy; Protein Conformation; Rats; Rats, Wistar; Receptors, Serotonin | 2016 |
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Death; Cell Line; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Naphthalenes; Peptide Fragments; Piperidines; Structure-Activity Relationship; Sulfonamides | 2017 |
Effect of centbucridine & lignocaine on biochemical changes in isoproterenol induced ischemia in rats.
Topics: Acid Phosphatase; Anesthetics, Local; Animals; Coronary Disease; Isoproterenol; Lidocaine; Lipolysis; Male; Phospholipids; Rats; Tacrine | 1991 |
Evaluation of centbucridine as a local anesthetic.
Topics: Acridines; Adult; Anesthetics, Local; Blood Pressure; Double-Blind Method; Drug Evaluation; Female; Humans; Lidocaine; Male; Middle Aged; Random Allocation; Tacrine | 1983 |
Evaluation of local anaesthetic activity of 4-N-butylamino-1,2,3,4-tetrahydroacridine hydrochloride (Centbucridine)--a 4-substituted polymethylenequinoline.
Topics: Acridines; Anesthetics, Local; Animals; Cats; Dogs; Drug Evaluation; Female; Guinea Pigs; Irritants; Lidocaine; Male; Rabbits; Tacrine | 1982 |
Pharmacological study of 4-N-butylamino-1,2,3,4-tetrahydroacridine hydrochloride (Centbucridine)--a new local anaesthetic agent.
Topics: Acridines; Anesthetics, Local; Animals; Cats; Female; Guinea Pigs; Lidocaine; Macaca mulatta; Male; Mice; Rabbits; Rats; Tacrine | 1982 |
Tetrahydroaminoacridine and D-cycloserine fail to alleviate the water maze spatial navigation defect induced by hippocampal inactivation.
Topics: Anesthetics, Local; Animals; Choline O-Acetyltransferase; Cycloserine; Drug Therapy, Combination; Escape Reaction; Hippocampus; Infusions, Parenteral; Injections, Intraventricular; Learning Disabilities; Lidocaine; Male; Maze Learning; Nerve Degeneration; Parasympathomimetics; Rats; Rats, Wistar; Septum Pellucidum; Swimming; Tacrine | 1999 |
Object location memory in mice: pharmacological validation and further evidence of hippocampal CA1 participation.
Topics: Animals; Central Nervous System Agents; Cholinesterase Inhibitors; Cycloserine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Injections, Intraperitoneal; Lidocaine; Locomotion; Male; Memory; Mice; Muscarinic Antagonists; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Scopolamine; Space Perception; Tacrine; Time Factors | 2009 |
Insight to Newer Agents and Methods for Local Anesthesia in Pediatric Dentistry.
Topics: Anesthesia, Local; Anesthetics, Local; Child; Humans; Lidocaine; Pediatric Dentistry; Tacrine | 2020 |