lidocaine and ranitidine

lidocaine has been researched along with ranitidine in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19909 (23.68)18.7374
1990's1 (2.63)18.2507
2000's15 (39.47)29.6817
2010's13 (34.21)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Lombardo, F; Obach, RS; Waters, NJ1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Gozalbes, R; Pineda-Lucena, A1
Ekins, S; Williams, AJ; Xu, JJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Artursson, P; Mateus, A; Matsson, P1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Collier, PS; Flynn, RJ; Howard, PJ; Moore, J1
Heath, CA; Johnson, RF; Roberts, RK; Schenker, S; Speeg, KV1
Kapil, RP; Lalonde, RL; Mattern, AL; North, DS1
Cheek, DB; Dailey, PA; Healy, K; Hughes, SC; Rosen, MA; Shnider, SM1
Kim, KC; Tasch, MD1
Bentley, JB; Fukui, T; Gandolfi, AJ; Glass, SJ; Jackson, JE; Plachetka, JR1
Birkett, DJ; Lillywhite, KJ; Miners, JO; Robson, RA; Wing, LM1
Wood, JR1
Feely, J; Guy, E1
King, AD; Stewart, JT; Warren, FW1
Al Obaid, AR; Al Rasheed, NM; Al Sayed, MI; Al Zuhair, HH; Fatani, AJ1
Mata, JL; Restolho, J; Saramago, B1

Reviews

1 review(s) available for lidocaine and ranitidine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

4 trial(s) available for lidocaine and ranitidine

ArticleYear
Single dose oral H2-antagonists do not affect plasma lidocaine levels in the parturient.
    Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:7

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Drug Interactions; Female; Fetal Blood; Humans; Lidocaine; Pregnancy; Randomized Controlled Trials as Topic; Ranitidine

1989
The effect of histamine-2 receptor antagonists on tocainide pharmacokinetics.
    Journal of clinical pharmacology, 1988, Volume: 28, Issue:7

    Topics: Adult; Anti-Arrhythmia Agents; Cimetidine; Drug Interactions; Female; Half-Life; Histamine H2 Antagonists; Humans; Lidocaine; Male; Middle Aged; Ranitidine; Tocainide

1988
Effects of histamine-2 receptor blockade on lidocaine kinetics.
    Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:5

    Topics: Administration, Oral; Adult; Analysis of Variance; Chromatography, High Pressure Liquid; Cimetidine; Double-Blind Method; Drug Interactions; Half-Life; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Male; Orosomucoid; Ranitidine

1985
Lack of effect of ranitidine on the disposition of lignocaine.
    British journal of clinical pharmacology, 1983, Volume: 15, Issue:3

    Topics: Adult; Female; Furans; Half-Life; Histamine H2 Antagonists; Humans; Kinetics; Lidocaine; Male; Ranitidine

1983

Other Studies

33 other study(ies) available for lidocaine and ranitidine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Rational use of in vitro P-glycoprotein assays in drug discovery.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera

2001
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
QSAR-based solubility model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19

    Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
    Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3

    Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Effect of H2-receptor antagonists on steady-state extraction of indocyanine green and lidocaine by the perfused rat liver.
    The Journal of laboratory and clinical medicine, 1986, Volume: 107, Issue:2

    Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Indocyanine Green; Lidocaine; Liver; Male; Oxygen Consumption; Perfusion; Ranitidine; Rats; Rats, Inbred Strains

1986
Effect of cimetidine and ranitidine on lidocaine concentrations during epidural anesthesia for cesarean section.
    Anesthesiology, 1988, Volume: 69, Issue:6

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Cimetidine; Female; Fetal Blood; Humans; Lidocaine; Pregnancy; Ranitidine

1988
Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:8

    Topics: Anesthetics, Local; Animals; Brain Diseases; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Lidocaine; Mice; Procaine; Ranitidine; Seizures

1986
The effect of ranitidine on the disposition of lignocaine.
    British journal of clinical pharmacology, 1985, Volume: 20, Issue:2

    Topics: Adolescent; Adult; Biological Availability; Drug Interactions; Female; Humans; Lidocaine; Male; Metabolic Clearance Rate; Ranitidine

1985
H2 receptor antagonists: cimetidine and ranitidine.
    British medical journal (Clinical research ed.), 1983, Apr-30, Volume: 286, Issue:6375

    Topics: Cimetidine; Drug Interactions; Furans; Guanidines; Histamine H2 Antagonists; Humans; Lidocaine; Propranolol; Ranitidine

1983
Stability of ranitidine hydrochloride and seven medications.
    American journal of hospital pharmacy, 1994, Jul-15, Volume: 51, Issue:14

    Topics: Aminophylline; Chromatography, High Pressure Liquid; Dobutamine; Dopamine; Drug Stability; Humans; Lidocaine; Methylprednisolone; Nitroprusside; Norepinephrine; Ranitidine; Sodium Chloride

1994
Effects of two newly synthesized analogues of lidocaine on rat arterial blood pressure and heart rate.
    Pharmacological research, 2001, Volume: 43, Issue:4

    Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Atropine; Benzoates; Blood Pressure; Calcium Chloride; Cyproheptadine; Enzyme Inhibitors; Heart Rate; Hexamethonium; Histamine Agonists; Indomethacin; Lidocaine; Male; Monitoring, Physiologic; NG-Nitroarginine Methyl Ester; Pyrilamine; Quinacrine; Ranitidine; Rats; Rats, Wistar; Vasodilator Agents

2001
Peculiar surface behavior of some ionic liquids based on active pharmaceutical ingredients.
    The Journal of chemical physics, 2011, Feb-21, Volume: 134, Issue:7

    Topics: Dioctyl Sulfosuccinic Acid; Ibuprofen; Ionic Liquids; Lidocaine; Pharmaceutical Preparations; Quaternary Ammonium Compounds; Ranitidine; Surface Tension; Temperature

2011