lidocaine has been researched along with qx-314 in 276 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (10.51) | 18.7374 |
| 1990's | 88 (31.88) | 18.2507 |
| 2000's | 86 (31.16) | 29.6817 |
| 2010's | 70 (25.36) | 24.3611 |
| 2020's | 3 (1.09) | 2.80 |
| Authors | Studies |
|---|---|
| Almers, W; Cahalan, MD | 1 |
| Yeh, JZ | 2 |
| Ransom, BR; Stys, PK; Waxman, SG | 1 |
| Mooney, R | 1 |
| Mody, I; Otis, TS | 1 |
| Sastry, BR; Xie, Z | 1 |
| Callaway, JC; Jaffe, D; Johnston, D; Lasser-Ross, N; Lisman, JE; Miyakawa, H; Ross, WN | 1 |
| Andersen, P; Hu, GY; Hvalby, O; Lacaille, JC; Ostberg, T; Piercey, B | 1 |
| Ikemoto, Y; Oda, M; Yoshida, A | 1 |
| Baumgarten, CM; Fozzard, HA; Makielski, JC | 1 |
| Alpert, LA; Hanck, DA; Makielski, JC | 1 |
| Agnew, WS; Cooper, EC; Correa, AM; James, WM; Shenkel, S; Tomiko, SA; Ukomadu, C | 1 |
| Andrade, R | 1 |
| Gilbert, CD; Hirsch, JA | 1 |
| Lambert, JD; Nathan, T | 1 |
| Leung, LW; Yim, CY | 1 |
| Buño, W; Nuñez, A | 1 |
| Deisz, RA; Fortin, G; Zieglgänsberger, W | 1 |
| Avoli, M; Hwa, GG | 1 |
| Baranyi, A; Szente, MB; Woody, CD | 1 |
| Aceves, J; Bargas, J; Galarraga, E | 1 |
| Birt, D; Gruen, E; Woody, CD | 1 |
| Hu, GY | 1 |
| Nettleton, J; Wang, GK | 1 |
| Oortgiesen, M; van Kleef, RG; Vijverberg, HP | 1 |
| Jensen, MS; Lambert, JD; Nathan, T | 1 |
| Kita, H; Kita, T; Kitai, ST | 1 |
| Sernagor, E; Werman, R; Yarom, Y | 1 |
| Keynes, RD | 1 |
| Brodwick, MS; Eaton, DC; Strichartz, GR; Wang, GK | 1 |
| Mifflin, S; Richter, DW | 1 |
| Alpert, LA; Fozzard, HA; Hanck, DA; Makielski, JC | 1 |
| Tanguy, J; Yeh, JZ | 1 |
| Agnew, WS; Cooper, EC | 1 |
| Chubb, MC; Crill, WE; Schwindt, PC; Stafstrom, CE | 1 |
| Deschênes, M; Mulle, C; Steriade, M | 1 |
| Baranyi, A; Gruen, E; Holmes, W; Nenov, V; Strecker, GJ; Szente, MB; Woody, CD | 1 |
| Heinemann, U; Mody, I; Stanton, PK | 1 |
| Wang, GK | 1 |
| Marquis, JK | 1 |
| Chiappinelli, VA; Culver, P; Sorenson, EM | 1 |
| Danilo, P; Rosen, MR; Spinelli, W | 1 |
| Dudek, FE; Gribkoff, VK | 1 |
| Deschênes, M; Madariaga, A; Mulle, C | 1 |
| Bloch, RJ | 1 |
| Lee, KS; Tsien, RW | 1 |
| Brodwick, MS; Dickey, WD; Horn, R | 1 |
| Connors, BW; Prince, DA | 1 |
| Benardo, LS; Masukawa, LM; Prince, DA | 1 |
| Gintant, GA; Hoffman, BF; Naylor, RE | 1 |
| Farley, JM; Narahashi, T | 1 |
| Gintant, GA; Hoffman, BF | 1 |
| Basbaum, AI; Peterson, MA; Taylor, BK | 1 |
| Blakemore, C; Larkman, A; Nicoll, A | 1 |
| Juusola, M; Uusitalo, RO; Weckström, M | 1 |
| Tietz, EI; Xie, XH; Zeng, X | 1 |
| Chang, W; Strahlendorf, HK; Strahlendorf, JC | 1 |
| Perkins, KL; Wong, RK | 1 |
| Brownstone, RM; Gossard, JP; Hultborn, H | 1 |
| Kullmann, DM | 1 |
| Bernardi, G; Calabresi, P; Mercuri, NB; Pisani, A | 1 |
| Colling, SB; Wheal, HV | 1 |
| Catterall, WA; McPhee, JC; Ragsdale, DS; Scheuer, T | 1 |
| Berger, TW; Grace, AA; Nisenbaum, ES | 1 |
| Sakmann, B; Stuart, GJ | 1 |
| Beardsley, D; Gingrich, KJ; Yue, DT | 1 |
| Aitken, PG; Czéh, G; Somjen, GG | 1 |
| Aghajanian, GK; Alreja, M | 1 |
| Tinker, A; Williams, AJ | 1 |
| Amzica, F; Nuñez, A; Steriade, M | 1 |
| Butterworth, J; Cole, L; Marlow, G | 1 |
| Jones, R; Meissner, G; Xu, L | 1 |
| Isaac, JT; Wheal, HV | 1 |
| Andreasen, M; Hablitz, JJ | 1 |
| Doyle, DD; French, RJ; Zamponi, GW | 1 |
| Alonso, JM; Hirsch, JA; Reid, RC | 1 |
| Catterall, WA; Qu, Y; Rogers, J; Scheuer, T; Tanada, T | 1 |
| Baukrowitz, T; Yellen, G | 1 |
| Kawaguchi, Y; Wilson, CJ | 1 |
| Bloomfield, SA | 1 |
| Castillo, C; Díaz, ME; Recio-Pinto, E; Salazar, BC | 1 |
| Hounsgaard, J; Nedergaard, S | 1 |
| Gibson, IC; Logan, SD; Nolan, MF; Pickering, AE; Spanswick, D | 1 |
| Sayer, RJ; Talbot, MJ | 1 |
| Fleidervish, IA; Gutnick, MJ | 1 |
| Harada, Y; Kaseda, K; Mashimo, T; Tsuda, Y; Yanagida, T; Yoshiya, I | 1 |
| Agrawal, SK; Fehlings, MG | 1 |
| Ding, JP; Li, ZW; Lingle, CJ; Solaro, CR | 1 |
| Ito, KI; Kato, H; Miura, M; Miyakawa, H; Yoshioka, M | 1 |
| Grünschlag, CR; Haas, HL; Stevens, DR | 1 |
| Quan, C; Wang, GK; Wang, S | 1 |
| Dudley, SC; Fozzard, HA; Sunami, A | 1 |
| Bley, KR; Hunter, JC; Khabbaz, MA; Omana-Zapata, I | 1 |
| Avoli, M; Lopantsev, V | 1 |
| Grover, LM | 1 |
| Hochman, S; MacLean, JN; Schmidt, BJ | 1 |
| Armano, S; D'Angelo, E; De Filippi, G; Rossi, P; Taglietti, V | 1 |
| Quan, C; Wang, GK; Wang, SY | 1 |
| Alger, BE; Lenz, RA; Wagner, JJ | 1 |
| Kim, U; McCormick, DA | 1 |
| Bennett, DJ; Fedirchuk, B; Gorassini, M; Hultborn, H | 1 |
| Karlin, A; Pascual, JM | 1 |
| Ding, JP; Kalyanaraman, V; Li, ZW; Lingle, CJ | 1 |
| de Curtis, M; Forti, M; Radici, C | 1 |
| Masland, RH; Velte, TJ | 1 |
| Llinás, RR; Moreira, JE; Pozzo-Miller, LD | 1 |
| Mann-Metzer, P; Yarom, Y | 1 |
| Arledge, JA; Durieux, ME; Hönemann, CW; Sullivan, LM | 1 |
| Blisard, KS; Follis, FM; Pett, SB; Temes, RT; Varvitsiotis, PS; Wernly, JA | 1 |
| Cannon, RC; Chad, JE; Chen, Y; Wheal, HV | 1 |
| Ding, JP; Lingle, CJ; Xia, XM | 1 |
| Johnson, SW; Shen, KZ; Wu, YN | 1 |
| Aizenman, CD; Linden, DJ | 1 |
| Kaila, K; Paalasmaa, P; Smirnov, S; Uusisaari, M; Voipio, J | 1 |
| Heckman, CJ; Lee, RH | 1 |
| Andrzejewski, M; Ballantyne, D; Mückenhoff, K; Oyamada, Y; Scheid, P | 1 |
| Iwane, AH; Mashimo, T; Miyamoto, Y; Muto, E; Yanagida, T; Yoshiya, I | 1 |
| Lerma, J; López-García, JC; Rodríguez-Moreno, A | 1 |
| Clements, JD; Silver, RA | 1 |
| Fozzard, HA; Glaaser, IW; Sunami, A | 2 |
| Cahill, AL; Dlouhy, S; Fox, AP; Ghetti, B; Harkins, AB; Heller, A; Heller, B; Won, L | 1 |
| Anthony, DC; Gerner, P; Nakamura, T; Quan, CF; Wang, GK | 1 |
| de la Peña, E; Geijo-Barrientos, E | 1 |
| Abe, H; Oka, Y | 1 |
| Nettleton, JS; Spain, WJ | 1 |
| Brumberg, JC; McCormick, DA; Nowak, LG | 1 |
| Byford, AM; Durieux, ME; Fischer, LG; Hollmann, MW | 1 |
| Galligan, JJ; Khakh, BS; Lester, HA; Sydes, J; Zhou, X | 1 |
| Kilb, W; Luhmann, HJ | 1 |
| Gingrich, KJ; Kimbrough, JT | 1 |
| Karlin, A; Wilson, G | 1 |
| Slesinger, PA | 1 |
| Berger, A; Durieux, ME; Hollmann, MW; Wieczorek, KS | 1 |
| Wei, F; Zhuo, M | 1 |
| de Klaver, M; Durieux, ME; Henle, P; Hollmann, MW; Kamatchi, GL; Ritter, CH | 1 |
| Geddis, LM; Kutchai, H | 1 |
| Heinemann, U; Kaila, K; Palva, JM; Schmitz, D; Schuchmann, S; Stenkamp, K; Uusisaari, M | 1 |
| Akamine, T; Asahara, T; Asahi, M; Itoh, K; Kitagawa, H; Kumazawa, Y; Lin, M; Nishimura, Y; Saitoh, K; Shibuya, H; Yamamoto, T | 1 |
| Berman, N; Dunn, RJ; Maler, L | 1 |
| Barrionuevo, G; González-Burgos, G | 1 |
| Katz, LC; McQuiston, AR | 1 |
| Cecília, M; Parada, CA; Roveroni, RC; Tambeli, CH; Veiga, FA | 1 |
| Horenstein, BA; Papke, RL; Placzek, AN | 1 |
| Ellsworth, K; Fisher, RS; Javedan, SP; Smith, K; Wu, J | 1 |
| Barbry, P; Clerici, C; Folkesson, HG; Jayr, C; Laffon, M; Matthay, MA; Pittet, JF; Wang, Y | 1 |
| Biró, Z; Grillner, S; Hill, RH; Hu, GY | 1 |
| Puil, E; Schwarz, SK | 1 |
| Behnisch, T; Jäger, T; Reymann, KG | 1 |
| Higashi, H; Inokuchi, H; Isagai, T; Li, JS; Tanaka, E; Wang, DS | 1 |
| Stanford, IM | 1 |
| Deadwyler, SA; Hampson, RE; Weiner, JL; Zhuang, SY | 1 |
| Fortune, ES; Rose, GJ | 1 |
| Bischoff, U; Bräu, ME; Hempelmann, G; Olschewski, A; Vogel, W | 1 |
| Andrade, R; Béïque, JC; Chapin-Penick, EM; Mladenovic, L | 1 |
| Grenier, F; Steriade, M; Timofeev, I | 1 |
| Curti, S; Pereda, AE | 1 |
| Enoki, R; Kiuchi, T; Koizumi, A; Kudo, Y; Miyakawa, H; Sasaki, G | 1 |
| Hiraoka, M; Kimura, A; Kitabatake, A; Makita, N; Sakurada, H; Sasaki, K; Shirai, N; Sunami, A; Tohse, N; Yokoi, H | 1 |
| Bazhenov, M; Fuentealba, P; Sejnowski, TJ; Steriade, M; Timofeev, I | 1 |
| Durieux, ME; Hahnenkamp, K; Hollmann, MW; Hönemann, CW; Podranski, T; Strumper, D | 1 |
| Crochet, S; Fuentealba, P; Steriade, M | 1 |
| Francis, NN; Kantrowitz, JT; Perkins, KL; Salah, A | 1 |
| Barros, SP; Oliveira, MC; Parada, CA; Rodrigues, LR; Tambeli, CH; Veiga, MC | 1 |
| Sasaki, K | 1 |
| Barnes, NY; Parent, AT; Sisodia, SS; Taniguchi, Y; Thinakaran, G | 1 |
| Ichinose, T; Lukasiewicz, PD; Shields, CR | 1 |
| Cummins, TR; Dib-Hajj, SD; Herzog, RI; Leffler, A; Waxman, SG | 1 |
| Abeniyi, OA; Conn, PJ; Poisik, O; Raju, DV; Rodriguez, A; Smith, Y; Verreault, M | 1 |
| Deadwyler, SA; Hampson, RE; Zhuang, S | 1 |
| Contreras, D; Wilent, WB | 1 |
| Binshtok, AM; Fleidervish, IA; Gutnick, MJ; Sprengel, R | 1 |
| Knöpfel, T; Yuan, Q | 1 |
| Furuse, S; Kawamata, M; Kiya, T; Namiki, A; Narimatsu, E; Sugino, S; Yamauchi, M | 1 |
| Huda, K; Imoto, K; Inoue, T; Miyata, M; Sasaki, S | 1 |
| Miftahof, RN | 1 |
| Terman, GW; Thomson, LM; Zeng, J | 1 |
| Bianchi, R; Chuang, SC; Wong, RK | 1 |
| Humeau, Y; Lüthi, A | 1 |
| DeWeese, MR; Zador, AM | 1 |
| Jia, Z; Toyoda, H; Wu, LJ; Xu, H; Zhao, MG; Zhuo, M | 1 |
| Bae, YC; Hirai, T; Kang, Y; Maeda, Y; Saito, M; Sato, H; Toyoda, H | 1 |
| Del Negro, CA; Feldman, JL; Mackay, DD; Pace, RW | 1 |
| Lim, TK; Macleod, BA; Ries, CR; Schwarz, SK | 1 |
| McCleskey, EW | 1 |
| Bean, BP; Binshtok, AM; Woolf, CJ | 1 |
| Ahern, CA; Dougherty, DA; Eastwood, AL; Horn, R | 1 |
| Kasaba, T; Onizuka, S; Takasaki, M; Tamura, R | 1 |
| Grothe, B; Koch, U; Magnusson, AK; Park, TJ; Pecka, M | 1 |
| Bruhova, I; Tikhonov, DB; Zhorov, BS | 1 |
| Bonjardim, LR; da Silva, AP; Ferraz de Arruda Veiga, MC; Gameiro, GH; Tambeli, CH | 1 |
| Carlisle, HJ; Fink, AE; Grant, SG; O'Dell, TJ | 1 |
| Basu, AC; Benneyworth, MA; Bergeron, R; Coyle, JT; Ehmsen, JT; Froimowitz, MP; Han, L; Jiang, ZI; Lange, N; Ma, CL; Mustafa, AK; Snyder, SH; Tsai, GE | 1 |
| Chanda, B; Muroi, Y | 1 |
| Fox, K; Hardingham, NR; Phillips, KG | 1 |
| Bianchi, BR; Cavanaugh, EJ; Chen, J; Faltynek, CR; Kim, D; Kym, PR; Reilly, RM | 1 |
| Amar, M; Baux, G; Fossier, P; Frégnac, Y; Lucas-Meunier, E; Monier, C | 1 |
| Cohen, D; Segal, M | 1 |
| Bolshakov, VY; Kang, JS; Krupa, B; Li, Y; Liu, G | 1 |
| Bean, BP; Binshtok, AM; Chung, G; Gerner, P; Herbert, T; Kim, D; Mitani, AA; Oh, SB; Puopolo, M; Roberson, DP; Suzuki, S; Wang, CF; Wang, GK; Woolf, CJ | 1 |
| Chung, CC; MacLeod, BA; Pillai, R; Ries, CR; Schwarz, SK; Wang, JT | 1 |
| Armogida, M; Giustizieri, M; Mercuri, NB; Nisticò, R; Piccirilli, S; Zona, C | 1 |
| Kohane, DS; Sagie, I | 1 |
| Ahn, DK; Bean, BP; Binshtok, AM; Chung, G; Hwang, SJ; Jung, SJ; Kang, Y; Kim, HY; Kim, JS; Kim, K; Lee, MK; Li, HY; Oh, SB; Park, CK; Woolf, CJ | 1 |
| Luna, VM; Pettit, DL | 1 |
| Lukacs, P; Mike, A | 1 |
| Arai, I; Tachibana, M; Tanaka, M | 1 |
| Cheung, HM; Lee, SM; MacLeod, BA; Ries, CR; Schwarz, SK; Wang, JT | 1 |
| Alaei, S; Baharvand, H; Gourabi, H; Hatami, M; Hemmesi, K; Kiani, S; Masoudi, N; Nemati, S | 1 |
| Bae, YC; Chung, G; Jo, HJ; Jung, SJ; Kim, HY; Kim, JS; Kim, YS; Oh, SB | 1 |
| Cheung, HM; Lee, SM; MacLeod, BA; Ries, CR; Schwarz, SK | 1 |
| Bean, BP; Binshtok, AM; Blasl, F; Roberson, DP; Woolf, CJ | 1 |
| Adachi, M; Bal, M; Kavalali, ET; Monteggia, LM; Sara, Y | 1 |
| Alberola-Die, A; González-Ros, JM; Ivorra, I; Martinez-Pinna, J; Morales, A | 1 |
| Ahern, CA; Pless, SA; Rivera-Acevedo, RE; Schwarz, SK | 2 |
| Akiyuki, S; Kawamata, M; Kawamata, T; Shimizu, F; Tanaka, S | 1 |
| Bruckner-Tuderman, L; Chiang, LY; Duarte, N; Hu, J; Koch, M; Lewin, GR; Oliveira, BE; Poole, K; Sierra, YA | 1 |
| Kronewald, S; Lattrell, A; Leffler, A; Nau, C; Niedermirtl, F | 1 |
| Berrebi, AS; Felix, RA; Fridberger, A; Leijon, S; Magnusson, AK | 1 |
| Sargent, PB; Stanchev, D | 1 |
| Cao, JL; Hou, HY; Liu, H; Lu, XF; Wang, CG; Wei, JQ; Wu, YP; Zeng, YM; Zhang, HX; Zhang, LC | 1 |
| Jeong, HJ; Li, L; Lin, D; Zuo, Z | 1 |
| Hanse, E; Riebe, I | 1 |
| Kuo, RI; Wu, GK | 1 |
| Ackerman, MJ; Bernard, CE; Beyder, A; Farrugia, G; Makielski, J; Reyes, S; Strege, PR; Terzic, A | 1 |
| Cope, TC; Nardelli, P; Powers, RK | 1 |
| Ahern, CA; Goodchild, SJ; Lee, S | 1 |
| Cheng, J; Fox, LE; Shen, J | 1 |
| Main, MJ; Morton, MJ | 1 |
| Binshtok, AM; Hitomi, S; Iwata, K; Kitagawa, J; Lev, S; Maeda, T; Mostafeezur, RM; Seo, K; Suzuki, A; Suzuki, I; Yamada, Y; Yamamura, K; Zakir, HM | 1 |
| Bamford, IJ; Bamford, NS; Lemos, JC; Lewis, JS; Nitulescu, I; Phillips, PE; Posielski, NM; Storey, GP; Wang, W | 1 |
| Bean, BP; Brenneis, C; Cobos, EJ; Ferreirós, N; Geisslinger, G; Ghasemlou, N; Kistner, K; Labocha, S; Puopolo, M; Reeh, PW; Roberson, D; Segal, D; Sisignano, M; Strominger, A; Woolf, CJ | 1 |
| Bean, BP; Binshtok, AM; Oh, SB; Puopolo, M; Woolf, CJ; Yao, GL | 1 |
| Eysel, UT; Imbrosci, B; Koesling, D; Mergia, E; Mittmann, T; Neitz, A; Petrasch-Parwez, E | 1 |
| Bargas, J; Carrillo-Reid, L; Drucker-Colin, R; Fiordelisio, T; Galarraga, E; López-Huerta, VG; Tapia, D | 1 |
| Alkon, DL; Hongpaisan, J; Nelson, TJ; Sen, A; Xu, C | 1 |
| Lovinger, DM; Mathur, BN; Tamamaki, N; Tanahira, C | 1 |
| Ahn, JS; Badral, B; Chung, G; Davies, AJ; Hong, SD; Kim, JS; Kim, YH; Oh, SB | 1 |
| Akaike, N; Maeda, M; Mizuno, Y; Nonaka, K; Shin, MC; Shoudai, K; Wakita, M; Yamaga, T | 1 |
| Bean, BP; Brenneis, C; Cobos, EJ; Ferreirós, N; Geisslinger, G; Jo, S; Kistner, K; Labocha, S; Puopolo, M; Reeh, PW; Roberson, D; Segal, D; Sisignano, M; Tran, J; von Hehn, C; Wainger, BJ; Woolf, CJ | 1 |
| Aschenbrenner, CA; Eisenach, JC; Houle, TT; Peters, CM; Ririe, D | 1 |
| Bean, BP; Jo, S | 1 |
| Chen, X; Chen, Y; Li, T; Liang, P; Liao, D; Liu, J; Zhang, W; Zhou, C | 1 |
| Chungt, YI; Kim, JC; Kim, YH; Tae, G | 1 |
| Chen, X; Chen, Y; Liang, P; Liao, D; Liu, J; Zhao, Y; Zhou, C | 1 |
| Inoue, K; Leng, TD; Lin, J; O'Bryant, Z; Sun, HW; Xiong, ZG; Zeng, Z | 1 |
| Andresen, MC; Fawley, JA; Hofmann, ME; Largent-Milnes, TM | 1 |
| Catterall, WA; Jones, CJ; Rubinstein, M; Scheuer, T; Westenbroek, RE; Yu, FH | 1 |
| Arase, M; Bertolini, JF; Fischer, L; Lima, MMS; Pontarolla, FM; Tobaldini, G; Tomim, DH | 1 |
| Frank, JA; Lewin, GR; Moroni, M; Moshourab, R; Sumser, M; Trauner, D | 1 |
| Abdulnour, RE; Agac, B; Bean, BP; Burkett, PR; Chiu, IM; Cronin, SJ; DiBiase, M; Foster, SL; Ghasemlou, N; Haworth, O; Kuchroo, VK; Laedermann, C; Lai, N; Lee, S; Levy, BD; Pascal, MA; Penninger, JM; Roberson, D; Seki, H; Talbot, S; Tran, JV; Von Hehn, C; Woolf, CJ | 1 |
| Li, WC | 1 |
| Harrington, M | 1 |
| Bang, S; Berta, T; Ji, RR; Kim, YH; Oh, SB; Wang, F; Xu, ZZ; Zhang, Y | 1 |
| Peirs, C; Seal, RP | 1 |
| Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K | 1 |
| Binshtok, AM; Dick, F; Eberhardt, MJ; Hadamitzky, C; Jangra, A; Kistner, K; Leffler, A; Reeh, PW; Schenk, S; Stoetzer, C; Stueber, T | 1 |
| Hayakawa, C; Onimaru, H; Takahashi, K | 1 |
| Trussell, LO; Yaeger, DB | 1 |
| Fuseya, S; Kawamata, M; Kawamata, T; Minemura, H; Yamamoto, K; Yamaori, S | 1 |
| Chen, G; Chen, X; Feng, P; Guan, Y; Kang, Y; Ke, B; Nie, Y; Yin, Q; Zhang, W | 1 |
| McCoy, DD; McKemy, DD; Ongun, S; Palkar, R; Yang, Y | 1 |
| Tikhonov, DB; Zhorov, BS | 1 |
| Li, J; Liu, J; Lv, R; Ma, L; Yang, X; Yin, Q; Zhang, W; Zheng, Q; Zhu, T | 1 |
| Liu, J; Yang, J; Yang, L; Yin, Q; Zhang, W; Zhang, Y | 1 |
| Liu, J; Yang, L; Yin, Q; Zhang, W; Zhao, W | 1 |
| Adams, KL; Baral, P; Blake, KJ; Chiu, IM; Lubkin, A; Ma, YC; Otto, M; Pinho-Ribeiro, FA; Roberson, DP; Torres, VJ; Voisin, T; Woolf, CJ | 1 |
| Dong, L; Kopach, O; Rusakov, DA; Sapelkin, A; Sukhorukov, GB; Voitenko, N; Zheng, K | 1 |
| Hu, Y; Yu, S; Yu, X | 1 |
| Andrews, NA; Bean, BP; Heckman, LM; Jacquemont, T; Jain, A; Jo, S; Kotoda, M; Lee, J; Lee, S; Liu, PW; Pascal, M; Puopolo, M; Talbot, S; Woolf, CJ; Zhang, HB | 1 |
| Go, EJ; Hwang, SM; Im, ST; Kim, YH; Lee, K; Park, CK | 1 |
| Aoki, S; Dai, Y; Duan, S; Ishikawa, M; Iwaoka, E; Kanda, H; Kogure, Y; Mizuta, K; Noguchi, K; Sonoda, H; Takeda, S; Wang, S; Yamamoto, S; Yang, Y | 1 |
| Carter, DA; Cox, JJ; Deuis, JR; Durek, T; Israel, MR; Klasfauseweh, T; Leffler, A; Ragnarsson, L; Vetter, I | 1 |
3 review(s) available for lidocaine and qx-314
| Article | Year |
|---|---|
Voltage-sensitive sodium channels: agents that perturb inactivation gating.
Topics: Amino Acid Sequence; Anesthetics, Local; Animals; Bungarotoxins; Electric Organ; Electrophorus; Ion Channel Gating; Lidocaine; Membrane Potentials; Molecular Sequence Data; Neurotoxins; Peptide Mapping; Sodium Channels | 1991 |
The enigmatic drug binding site for sodium channel inhibitors.
Topics: Anesthetics, Local; Anticonvulsants; Binding Sites; Lidocaine; Mutagenesis; Protein Structure, Secondary; Protein Structure, Tertiary; Sodium Channel Blockers; Sodium Channels | 2010 |
[Potentials for differential block with local anesthetics].
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Drug Design; Humans; Levobupivacaine; Lidocaine; Nociceptors; Physical Stimulation; Sodium Channel Blockers; Sodium Channels; TRPV Cation Channels | 2010 |
273 other study(ies) available for lidocaine and qx-314
| Article | Year |
|---|---|
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin.
Topics: Animals; Axons; Decapodiformes; Ion Channels; Lidocaine; Sodium; Tetrodotoxin | 1979 |
Sodium inactivation mechanism modulates QX-314 block of sodium channels in squid axons.
Topics: Animals; Axons; Decapodiformes; Electric Conductivity; Ion Channels; Lidocaine; Membrane Potentials; Pronase; Sodium | 1978 |
Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability.
Topics: Action Potentials; Anesthetics, Local; Animals; Hypoxia, Brain; In Vitro Techniques; Lidocaine; Neurons; Optic Nerve; Procaine; Rats; Sodium Channels | 1992 |
Synaptic basis for developmental plasticity in a birdsong nucleus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Anesthetics, Local; Animals; Axons; Birds; Brain; Efferent Pathways; Evoked Potentials; In Vitro Techniques; Lidocaine; Membrane Potentials; Models, Neurological; Neuronal Plasticity; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors; Vocalization, Animal | 1992 |
Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Anesthetics, Local; Animals; Calcium Channels; Evoked Potentials; Flumazenil; Hippocampus; Kinetics; Lidocaine; Mathematics; Meglumine; Membrane Potentials; Midazolam; Models, Neurological; Neurons; Pentobarbital; Probability; Quinoxalines; Rats; Rats, Wistar; Receptors, GABA-A; Synapses; Tetrodotoxin | 1992 |
Actions of somatostatin on GABA-ergic synaptic transmission in the CA1 area of the hippocampus.
Topics: Animals; Calcium; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Neurons; Protein Kinase C; Receptors, GABA-A; Receptors, Serotonin; Somatostatin; Synapses; Synaptic Transmission | 1992 |
Synaptically activated increases in Ca2+ concentration in hippocampal CA1 pyramidal cells are primarily due to voltage-gated Ca2+ channels.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Calcium; Calcium Channels; Dendrites; Electric Stimulation; Evoked Potentials; Fura-2; Hippocampus; In Vitro Techniques; Ion Channel Gating; Kinetics; Lidocaine; Male; Neurons; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Synapses | 1992 |
Synaptically triggered action potentials begin as a depolarizing ramp in rat hippocampal neurones in vitro.
Topics: Animals; Evoked Potentials; Hippocampus; Lidocaine; Male; Membrane Potentials; Neurons; Rats; Rats, Wistar; Synapses | 1992 |
Blockade by local anaesthetics of the single Ca(2+)-activated K+ channel in rat hippocampal neurones.
Topics: Anesthetics, Local; Animals; Benzocaine; Calcium; Female; Hippocampus; In Vitro Techniques; Lidocaine; Male; Neurons; Potassium Channels; Rats; Rats, Inbred Strains | 1992 |
External site for local anesthetic block of cardiac Na+ channels.
Topics: Anesthetics, Local; Animals; Dogs; In Vitro Techniques; Lidocaine; Membrane Potentials; Myocardium; Sodium Channels | 1991 |
Two components of use-dependent block of sodium current by lidocaine in voltage clamped cardiac Purkinje cells.
Topics: Animals; Dogs; Electric Conductivity; Electrochemistry; Hydrogen-Ion Concentration; Lidocaine; Purkinje Cells; Sodium Channels | 1991 |
Blockade of neurotransmitter-activated K+ conductance by QX-314 in the rat hippocampus.
Topics: Animals; Baclofen; Calcium; Hippocampus; Lidocaine; Membrane Potentials; Norepinephrine; Potassium Channels; Rats; Receptors, GABA-A; Receptors, Serotonin; Serotonin | 1991 |
Synaptic physiology of horizontal connections in the cat's visual cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Baclofen; Bicuculline; Cats; Electric Stimulation; Electrophysiology; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Lidocaine; Receptors, GABA-A; Synapses; Visual Cortex | 1991 |
Depression of the fast IPSP underlies paired-pulse facilitation in area CA1 of the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Evoked Potentials; Hippocampus; In Vitro Techniques; Lidocaine; Neurons; Pyramidal Tracts; Rats; Rats, Inbred Strains; Synapses; Time Factors | 1991 |
Intrinsic membrane potential oscillations in hippocampal neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Barium; Cadmium; Calcium; Choline; Evoked Potentials; Hippocampus; In Vitro Techniques; Interneurons; Ion Channels; Kinetics; Lidocaine; Male; Membrane Potentials; Neurons; Neurotoxins; Pyramidal Tracts; Rats; Rats, Inbred Strains; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1991 |
Intracellular effects of QX-314 and Cs+ in hippocampal pyramidal neurons in vivo.
Topics: Anesthetics, Local; Animals; Cesium; Chlorides; Electric Stimulation; Hippocampus; Lidocaine; Membrane Potentials; Neurons; Pyramidal Tracts; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Voltage dependence of excitatory postsynaptic potentials of rat neocortical neurons.
Topics: Action Potentials; Animals; Cerebral Cortex; Lidocaine; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 1991 |
Hyperpolarizing inward rectification in rat neocortical neurons located in the superficial layers.
Topics: Animals; Barium; Cerebral Cortex; Cesium; Ion Channel Gating; Lidocaine; Male; Membrane Potentials; Neurons; Potassium Channels; Rats; Rats, Inbred Strains | 1991 |
Properties of associative long-lasting potentiation induced by cellular conditioning in the motor cortex of conscious cats.
Topics: Action Potentials; Adaptation, Physiological; Anesthetics, Local; Animals; Cats; Electric Stimulation; Evoked Potentials; Habituation, Psychophysiologic; Lidocaine; Membrane Potentials; Microinjections; Motor Cortex; Pyramidal Tracts; Synapses; Thalamic Nuclei | 1991 |
Dendritic activity on neostriatal neurons as inferred from somatic intracellular recordings.
Topics: Action Potentials; Anesthetics, Local; Animals; Corpus Striatum; Dendrites; Electric Stimulation; Evoked Potentials; In Vitro Techniques; Lidocaine; Neurons; Rats; Rats, Inbred Strains; Strontium; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Changes in membrane currents during Pavlovian conditioning of single cortical neurons.
Topics: Acoustic Stimulation; Action Potentials; Anesthetics, Local; Animals; Cats; Cerebral Cortex; Conditioning, Classical; Evoked Potentials; Lidocaine; Membrane Potentials; Motor Cortex; Neurons; Sodium Glutamate | 1991 |
Effects of depolarization and QX-314 injection on slow prepotentials in rat hippocampal pyramidal neurones in vitro.
Topics: Action Potentials; Anesthetics, Local; Animals; Hippocampus; Lidocaine; Male; Microinjections; Neurons; Rats; Rats, Inbred Strains | 1991 |
pH-dependent binding of local anesthetics in single batrachotoxin-activated Na+ channels. Cocaine vs. quaternary compounds.
Topics: Anesthetics, Local; Animals; Batrachotoxins; Binding Sites; Cocaine; Hydrogen-Ion Concentration; Kinetics; Lidocaine; Lipid Bilayers; Models, Biological; Muscles; Naphthalenes; Phosphatidylcholines; Phosphatidylethanolamines; Protein Binding; Pyrrolidinones; Rabbits; Sodium Channels | 1990 |
Block of deltamethrin-modified sodium current in cultured mouse neuroblastoma cells: local anesthetics as potential antidotes.
Topics: Anesthetics, Local; Animals; Cell Line; Electric Conductivity; Insecticides; Kinetics; Lidocaine; Membrane Potentials; Mice; Neuroblastoma; Nitriles; Pyrethrins; Sodium Channels; Tetrodotoxin; Tumor Cells, Cultured | 1990 |
The slow inhibitory postsynaptic potential in rat hippocampal CA1 neurones is blocked by intracellular injection of QX-314.
Topics: Action Potentials; Anesthetics; Animals; Electric Stimulation; Hippocampus; In Vitro Techniques; Lidocaine; Neural Inhibition; Potassium Channels; Rats; Rats, Inbred Strains | 1990 |
Local stimulation induced GABAergic response in rat striatal slice preparations: intracellular recordings on QX-314 injected neurons.
Topics: Animals; Chlorides; Corpus Striatum; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channels; Lidocaine; Pentobarbital; Rats; Sodium; Synaptic Transmission | 1985 |
Sodium-dependent regenerative responses in dendrites of axotomized motoneurons in the cat.
Topics: Action Potentials; Animals; Axons; Calcium; Cats; Cesium; Dendrites; Ion Channels; Lidocaine; Motor Neurons; Nerve Regeneration; Potassium; Sodium | 1986 |
Properties of the sodium gating current in the squid giant axon.
Topics: Anesthetics, Local; Animals; Axons; Benzocaine; Ion Channels; Lidocaine; Membrane Potentials; Neural Conduction; Sodium; Tetrodotoxin | 1986 |
Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation.
Topics: Anesthetics, Local; Animals; Axons; Chloramines; Decapodiformes; Electric Conductivity; Etidocaine; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Pronase; Sodium; Tosyl Compounds | 1987 |
The effects of QX-314 on medullary respiratory neurones.
Topics: Action Potentials; Animals; Cats; Female; Ion Channels; Lidocaine; Male; Medulla Oblongata; Respiratory Center; Sodium | 1987 |
Is there a second external lidocaine binding site on mammalian cardiac cells?
Topics: Action Potentials; Animals; Binding Sites; Dogs; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Lidocaine; Myocardium; Sodium Channels | 1989 |
QX-314 restores gating charge immobilization abolished by chloramine-T treatment in squid giant axons.
Topics: Anesthetics, Local; Animals; Axons; Chloramines; Decapodiformes; In Vitro Techniques; Kinetics; Lidocaine; Sodium Channels; Tosyl Compounds | 1989 |
Reconstituted voltage-sensitive sodium channels from eel electroplax: activation of permeability by quaternary lidocaine, N-bromoacetamide, and N-bromosuccinimide.
Topics: Acetamides; Animals; Bromosuccinimide; Cell Membrane Permeability; Electric Organ; Electrophorus; Lidocaine; Neurotoxins; Rubidium Radioisotopes; Sodium Channels; Sodium Radioisotopes; Succinimides | 1989 |
Properties of persistent sodium conductance and calcium conductance of layer V neurons from cat sensorimotor cortex in vitro.
Topics: Animals; Barium; Calcium; Cats; Evoked Potentials; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Motor Cortex; Sodium; Somatosensory Cortex; Tetrodotoxin | 1985 |
The effects of QX314 on thalamic neurons.
Topics: Animals; Calcium; Cats; Ion Channels; Lidocaine; Membrane Potentials; Potassium; Sodium; Thalamic Nuclei | 1985 |
An aminopyridine-sensitive, early outward current recorded in vivo in neurons of the precruciate cortex of cats using single-electrode voltage-clamp techniques.
Topics: Aminopyridines; Animals; Cats; Cerebral Cortex; Lidocaine; Membrane Potentials; Tetrodotoxin | 1989 |
Activation of N-methyl-D-aspartate receptors parallels changes in cellular and synaptic properties of dentate gyrus granule cells after kindling.
Topics: Amygdala; Animals; Calcium; Cell Membrane; Electrophysiology; Granulocytes; Hippocampus; Kindling, Neurologic; Lidocaine; Magnesium; Osmolar Concentration; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1988 |
Cocaine-induced closures of single batrachotoxin-activated Na+ channels in planar lipid bilayers.
Topics: Anesthetics, Local; Animals; Batrachotoxins; Binding Sites; Bupivacaine; Cocaine; Dose-Response Relationship, Drug; Electrophysiology; Lidocaine; Lipid Bilayers; Muscles; Rabbits; Sodium Channels | 1988 |
Osmotically-induced trapping of terbium ions in axonal membrane vesicles.
Topics: Animals; Axons; Binding Sites; Edetic Acid; In Vitro Techniques; Kinetics; Lidocaine; Membranes; Nephropidae; Osmotic Pressure; Spectrometry, Fluorescence; Terbium | 1985 |
Lophotoxin: selective blockade of nicotinic transmission in autonomic ganglia by a coral neurotoxin.
Topics: Action Potentials; Animals; Bungarotoxins; Chick Embryo; Cnidarian Venoms; Diterpenes; Ganglia, Autonomic; Lidocaine; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Synaptic Transmission; Terpenes; Tubocurarine | 1987 |
Reduction of Vmax by QX-314 and benzocaine in neonatal and adult canine cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Animals, Newborn; Benzocaine; Dogs; Heart Conduction System; Kinetics; Lidocaine; Membrane Potentials; Purkinje Fibers | 1988 |
Synaptic activation of slow depolarization in rat supraoptic nucleus neurones in vitro.
Topics: Action Potentials; Animals; Calcium; In Vitro Techniques; Lidocaine; Magnesium; Membrane Potentials; Neurons; Rats; Sensory Thresholds; Supraoptic Nucleus; Synapses; Time Factors | 1987 |
Morphology and electrophysiological properties of reticularis thalami neurons in cat: in vivo study of a thalamic pacemaker.
Topics: Animals; Calcium; Cats; Dendrites; Electric Stimulation; Electrophysiology; Evoked Potentials; Lidocaine; Membrane Potentials; Neurons; Reticular Formation; Thalamus | 1986 |
Loss of acetylcholine receptor clusters induced by treatment of cultured rat myotubes with carbachol.
Topics: Animals; Calcium; Carbachol; Chlorides; Dose-Response Relationship, Drug; Fluphenazine; Lidocaine; Muscles; Potassium; Proadifen; Protease Inhibitors; Protein Conformation; Rats; Receptors, Cholinergic; Sodium | 1986 |
High selectivity of calcium channels in single dialysed heart cells of the guinea-pig.
Topics: Action Potentials; Animals; Barium; Cadmium; Calcium; Cesium; Female; Guinea Pigs; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Myocardium; Sodium | 1984 |
Asymmetry of the acetylcholine channel revealed by quaternary anesthetics.
Topics: Acetylcholine; Animals; Ion Channels; Lidocaine; Membrane Potentials; Membrane Proteins; Motor Endplate; Neuromuscular Junction; Rats; Receptors, Cholinergic; Sodium; Structure-Activity Relationship | 1980 |
Effects of local anesthetic QX-314 on the membrane properties of hippocampal pyramidal neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Membranes; Microelectrodes; Neurons; Pyramidal Tracts; Synapses; Synaptic Transmission; Tetrodotoxin | 1982 |
A pharmacological approach to the structure of the Na channel in squid axon.
Topics: Animals; Axons; Decapodiformes; Guanidines; In Vitro Techniques; Ion Channels; Kinetics; Lidocaine; Membrane Potentials; Models, Biological; Pancuronium; Sodium; Structure-Activity Relationship | 1982 |
Electrophysiology of isolated hippocampal pyramidal dendrites.
Topics: Action Potentials; Animals; Calcium; Dendrites; Denervation; Electrophysiology; Guinea Pigs; Hippocampus; Lidocaine; Neural Conduction; Pyramidal Tracts; Sodium; Synaptic Transmission | 1982 |
The influence of molecular form of local anesthetic-type antiarrhythmic agents on reduction of the maximum upstroke velocity of canine cardiac Purkinje fibers.
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Benzocaine; Dogs; Heart Conduction System; Ion Channels; Lidocaine; Membrane Potentials; Molecular Conformation; Purkinje Fibers; Sodium; Tocainide | 1983 |
Effects of drugs on acetylcholine-activated ionic channels of internally perfused chick myoballs.
Topics: Acetylcholine; Action Potentials; Animals; Binding Sites; Cells, Cultured; Chick Embryo; Guanidines; Ion Channels; Lidocaine; Membrane Potentials; Motor Endplate; Muscles | 1983 |
Use-dependent block of cardiac sodium channels by quaternary derivatives of lidocaine.
Topics: Action Potentials; Animals; Dogs; Ion Channels; Lidocaine; Myocardium; Purkinje Fibers; Sodium | 1984 |
Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input.
Topics: Anesthesia; Anesthetics, Local; Animals; Behavior, Animal; Blood Pressure; Dose-Response Relationship, Drug; Formaldehyde; Halothane; Heart Rate; Injections, Subcutaneous; Lidocaine; Male; Nociceptors; Pain; Peripheral Nerves; Rats; Rats, Sprague-Dawley | 1995 |
Modulation of EPSP shape and efficacy by intrinsic membrane conductances in rat neocortical pyramidal neurons in vitro.
Topics: Animals; Cesium; Clonidine; Electric Conductivity; Evoked Potentials; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses; Visual Cortex | 1993 |
Graded responses and spiking properties of identified first-order visual interneurons of the fly compound eye.
Topics: Action Potentials; Anesthetics, Local; Animals; Axons; Dark Adaptation; Diptera; Interneurons; Iontophoresis; Lidocaine; Light; Ocular Physiological Phenomena; Photoreceptor Cells, Invertebrate; Retina; Sodium Channels | 1995 |
Reduction of GABA-mediated inhibitory postsynaptic potentials in hippocampal CA1 pyramidal neurons following oral flurazepam administration.
Topics: Acetates; Acetic Acid; Anesthetics, Local; Animals; Depression, Chemical; Electric Stimulation; Electrophysiology; Evoked Potentials; Flurazepam; GABA Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Lidocaine; Male; Organophosphorus Compounds; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium Channels; Synapses | 1995 |
Ionic contributions to the oscillatory firing activity of rat Purkinje cells in vitro.
Topics: Action Potentials; Anesthetics, Local; Animals; Cell Membrane; Cesium; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Neurotransmitter Agents; Purkinje Cells; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin | 1993 |
Intracellular QX-314 blocks the hyperpolarization-activated inward current Iq in hippocampal CA1 pyramidal cells.
Topics: Animals; Electric Conductivity; Electrophysiology; Guinea Pigs; Hippocampus; In Vitro Techniques; Intracellular Membranes; Lidocaine; Pyramidal Cells | 1995 |
Voltage-dependent excitation of motoneurones from spinal locomotor centres in the cat.
Topics: Action Potentials; Afferent Pathways; Anesthetics, Local; Animals; Cats; Electric Stimulation; Evoked Potentials; Female; Levodopa; Lidocaine; Locomotion; Male; Mesencephalon; Motor Activity; Motor Neurons; Nerve Fibers; Nialamide; Spinal Cord; Synaptic Transmission; Time Factors | 1994 |
Amplitude fluctuations of dual-component EPSCs in hippocampal pyramidal cells: implications for long-term potentiation.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Nerve Fibers; Pyramidal Cells; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synapses | 1994 |
Post-receptor mechanisms underlying striatal long-term depression.
Topics: Action Potentials; Anesthetics, Local; Animals; Calcium; Corpus Striatum; Egtazic Acid; Electrophysiology; Lidocaine; Long-Term Potentiation; Neuronal Plasticity; Neurons; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Second Messenger Systems | 1994 |
Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells.
Topics: Action Potentials; Anesthetics, Local; Animals; Cells, Cultured; Dendrites; Electric Stimulation; Evoked Potentials; Hippocampus; Lidocaine; Male; Pyramidal Cells; Rats; Rats, Wistar; Sodium Channels | 1994 |
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
Topics: Action Potentials; Anesthetics, Local; Animals; Binding Sites; Etidocaine; Lidocaine; Mutagenesis, Site-Directed; Oocytes; Rats; Sodium Channels; Xenopus | 1994 |
Depression of glutamatergic and GABAergic synaptic responses in striatal spiny neurons by stimulation of presynaptic GABAB receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; Corpus Striatum; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Lidocaine; Male; Neurons; Pregnanolone; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Sodium Channel Blockers; Synapses | 1993 |
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites.
Topics: Action Potentials; Animals; Axons; Dendrites; In Vitro Techniques; Lidocaine; Pyramidal Cells; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels | 1994 |
Ultra-deep blockade of Na+ channels by a quaternary ammonium ion: catalysis by a transition-intermediate state?
Topics: Animals; Binding Sites; Catalysis; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Kinetics; Lidocaine; Membrane Potentials; Models, Biological; Sodium Channel Blockers; Sodium Channels | 1993 |
Membrane currents in CA1 pyramidal cells during spreading depression (SD) and SD-like hypoxic depolarization.
Topics: Anesthetics, Local; Animals; Cell Hypoxia; Cesium; Cortical Spreading Depression; Electric Conductivity; Electric Stimulation; Hippocampus; In Vitro Techniques; Lidocaine; Membrane Potentials; Neurons; Potassium; Pyramidal Cells; Rats | 1993 |
QX-314 blocks the potassium but not the sodium-dependent component of the opiate response in locus coeruleus neurons.
Topics: Anesthetics, Local; Animals; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Lidocaine; Locus Coeruleus; Narcotic Antagonists; Neural Conduction; Neurons; Potassium Channels; Rats; Receptors, Opioid; Sodium Channels | 1994 |
Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel.
Topics: Anesthetics, Local; Animals; Calcium Channels; Dose-Response Relationship, Drug; Electric Conductivity; Ion Channel Gating; Kinetics; Lidocaine; Lipid Bilayers; Membrane Potentials; Procaine; Sarcoplasmic Reticulum; Sheep | 1993 |
A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components.
Topics: Action Potentials; Animals; Cats; Cerebral Cortex; Dendrites; Electrophysiology; Humans; Ketamine; Lidocaine; Motor Cortex; Neural Pathways; Neurons; Nitrous Oxide; Periodicity; Sleep; Thalamus; Visual Cortex; Xylazine | 1993 |
Inhibition of brain cell excitability by lidocaine, QX314, and tetrodotoxin: a mechanism for analgesia from infused local anesthetics?
Topics: Analgesia; Anesthetics, Local; Animals; Brain; In Vitro Techniques; Infusions, Intravenous; Lidocaine; Male; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1993 |
Effects of local anesthetics on single channel behavior of skeletal muscle calcium release channel.
Topics: Anesthetics, Local; Animals; Calcium Channels; Calcium Radioisotopes; In Vitro Techniques; Lidocaine; Lipid Bilayers; Muscles; Procaine; Rabbits; Ryanodine; Sarcoplasmic Reticulum; Tetracaine | 1993 |
The local anaesthetic QX-314 enables enhanced whole-cell recordings of excitatory synaptic currents in rat hippocampal slices in vitro.
Topics: Anesthetics, Local; Animals; Cadmium; Cadmium Chloride; Chlorides; Hippocampus; In Vitro Techniques; Lidocaine; Potassium Channels; Pyramidal Tracts; Rats; Sodium Channels; Synapses; Tetrodotoxin | 1993 |
Local anesthetics block transient outward potassium currents in rat neocortical neurons.
Topics: Anesthetics, Local; Animals; Cells, Cultured; Cerebral Cortex; Lidocaine; Membrane Potentials; Microinjections; Neurons; Potassium Channels; Rats; Sodium Channels | 1993 |
Fast lidocaine block of cardiac and skeletal muscle sodium channels: one site with two routes of access.
Topics: Animals; Batrachotoxins; Binding Sites; Binding, Competitive; Biophysical Phenomena; Biophysics; Cattle; Electrochemistry; Heart; In Vitro Techniques; Kinetics; Lidocaine; Muscles; Myocardium; Rats; Sheep; Sodium; Sodium Channels | 1993 |
Visually evoked calcium action potentials in cat striate cortex.
Topics: Action Potentials; Animals; Calcium; Cats; Corpus Striatum; Dendrites; Evoked Potentials, Visual; Lidocaine; Neurons; Patch-Clamp Techniques; Photic Stimulation; Sodium; Sodium Channels | 1995 |
Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel.
Topics: Amino Acid Sequence; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Binding Sites; Brain Chemistry; Electric Conductivity; Electrophysiology; Lidocaine; Molecular Sequence Data; Mutagenesis, Site-Directed; Myocardium; Oocytes; Protein Conformation; Rats; Recombinant Proteins; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship; Transfection; Xenopus | 1995 |
Use-dependent blockers and exit rate of the last ion from the multi-ion pore of a K+ channel.
Topics: Binding Sites; Cell Line; Humans; Lidocaine; Potassium; Potassium Channel Blockers; Potassium Channels; Quaternary Ammonium Compounds; Shaker Superfamily of Potassium Channels; Tetraethylammonium Compounds | 1996 |
The origins of two-state spontaneous membrane potential fluctuations of neostriatal spiny neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Cell Size; Cesium; Electrolytes; Electrophysiology; Gallopamil; Lidocaine; Membrane Potentials; Neostriatum; Neurons; Potassium; Potassium Channel Blockers; Rats; Rats, Inbred Strains | 1996 |
Effect of spike blockade on the receptive-field size of amacrine and ganglion cells in the rabbit retina.
Topics: Anesthetics, Local; Animals; Cell Size; Dendrites; Evoked Potentials, Visual; Ion Channel Gating; Lidocaine; Microelectrodes; Photic Stimulation; Rabbits; Receptors, Presynaptic; Retina; Retinal Ganglion Cells; Sodium Channels; Tetrodotoxin; Visual Fields | 1996 |
Multiple open channel states revealed by lidocaine and QX-314 on rat brain voltage-dependent sodium channels.
Topics: Anesthetics, Local; Animals; Binding Sites; Brain; Cell Membrane; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; Lidocaine; Osmolar Concentration; Rats; Sodium Channels | 1996 |
Fast Na+ spike generation in dendrites of guinea-pig substantia nigra pars compacta neurons.
Topics: Anesthetics, Local; Animals; Calcium Channel Blockers; Cobalt; Dendrites; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; Gap Junctions; Guinea Pigs; Halothane; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Neurons; Octanols; Propionates; Sodium; Substantia Nigra; Time Factors | 1996 |
Electrotonic coupling between rat sympathetic preganglionic neurones in vitro.
Topics: Action Potentials; Adrenergic Fibers; Anesthetics, Local; Animals; Autonomic Fibers, Preganglionic; Calcium; Electrophysiology; Gap Junctions; Lidocaine; Membrane Potentials; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord; Tetrodotoxin | 1996 |
Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.
Topics: Anesthetics, Local; Animals; Calcium Channel Blockers; Hippocampus; Lidocaine; Membrane Potentials; Models, Neurological; Pyramidal Cells; Rats; Sodium Channels | 1996 |
Kinetics of slow inactivation of persistent sodium current in layer V neurons of mouse neocortical slices.
Topics: Anesthetics, Local; Animals; Axons; Cerebral Cortex; Cesium; Electrophysiology; Female; Kinetics; Lidocaine; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Neurons; Patch-Clamp Techniques; Sodium Channels; Tetrodotoxin | 1996 |
Direct inhibition of the actomyosin motility by local anesthetics in vitro.
Topics: Actins; Actomyosin; Anesthetics, Local; Animals; Hydrogen-Ion Concentration; Lidocaine; Muscle Contraction; Myosin Subfragments; Myosins; Osmolar Concentration; Protein Binding; Rabbits; Tetracaine | 1996 |
The effect of the sodium channel blocker QX-314 on recovery after acute spinal cord injury.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Female; Lidocaine; Rats; Rats, Wistar; Spinal Cord Injuries; Time Factors | 1997 |
The cytosolic inactivation domains of BKi channels in rat chromaffin cells do not behave like simple, open-channel blockers.
Topics: Adrenal Medulla; Anesthetics, Local; Animals; Calcium; Cell Membrane; Cells, Cultured; Cesium; Chlorisondamine; Chromaffin Cells; Cytosol; Decamethonium Compounds; Ion Channel Gating; Kinetics; Large-Conductance Calcium-Activated Potassium Channels; Lidocaine; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Rats; Shaker Superfamily of Potassium Channels; Sodium | 1997 |
Properties of calcium spikes revealed during GABAA receptor antagonism in hippocampal CA1 neurons from guinea pigs.
Topics: Animals; Bicuculline; Cadmium; Calcium; Calcium Channel Blockers; Electric Stimulation; Electrophysiology; Evoked Potentials; GABA-A Receptor Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Nifedipine; omega-Agatoxin IVA; Picrotoxin; Pyramidal Cells; Sodium Channel Blockers; Spider Venoms; Tetrodotoxin; Virulence Factors, Bordetella | 1997 |
5-HT inhibits lateral entorhinal cortical neurons of the rat in vitro by activation of potassium channel-coupled 5-HT1A receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthetics, Local; Animals; Electrophysiology; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Lidocaine; Lysine; Male; Neural Inhibition; Neurons; Perforant Pathway; Potassium; Potassium Channels; Propranolol; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sympatholytics | 1997 |
A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels.
Topics: Amino Acid Sequence; Anesthetics, Local; Benzocaine; Cell Line; Electric Conductivity; Embryo, Mammalian; Etidocaine; Humans; Kidney; Lidocaine; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Drug; Sodium Channels | 1998 |
Sodium channel selectivity filter regulates antiarrhythmic drug binding.
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Binding Sites; Female; In Vitro Techniques; Lidocaine; Models, Biological; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Rats; Sodium Channel Blockers; Sodium Channels; Xenopus | 1997 |
QX-314 inhibits ectopic nerve activity associated with neuropathic pain.
Topics: Action Potentials; Anesthetics, Local; Animals; Blood Pressure; Heart Rate; Lidocaine; Male; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Vagus Nerve | 1997 |
Participation of GABAA-mediated inhibition in ictallike discharges in the rat entorhinal cortex.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Neurons; Potassium Acetate; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1998 |
Evidence for postsynaptic induction and expression of NMDA receptor independent LTP.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Axons; Dizocilpine Maleate; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Male; Membrane Potentials; Models, Neurological; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Synapses | 1998 |
NMDA receptor activation triggers voltage oscillations, plateau potentials and bursting in neonatal rat lumbar motoneurons in vitro.
Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Electric Stimulation; Excitatory Amino Acid Agonists; Ganglia, Spinal; Lidocaine; Motor Neurons; N-Methylaspartate; Patch-Clamp Techniques; Periodicity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin; Tetrodotoxin | 1997 |
The weaver mutation causes a loss of inward rectifier current regulation in premigratory granule cells of the mouse cerebellum.
Topics: Anesthetics, Local; Animals; Cell Movement; Cerebellum; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Lidocaine; Male; Membrane Potentials; Mice; Mice, Neurologic Mutants; Nerve Degeneration; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Muscarinic | 1998 |
Local anesthetic block of batrachotoxin-resistant muscle Na+ channels.
Topics: Anesthetics, Local; Batrachotoxins; Benzocaine; Cells, Cultured; Drug Resistance; Etidocaine; Humans; Lidocaine; Muscles; Sodium Channels | 1998 |
N- and L-type calcium channel involvement in depolarization-induced suppression of inhibition in rat hippocampal CA1 cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Lidocaine; Male; Nickel; Nifedipine; omega-Conotoxin GVIA; Peptides; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1998 |
Functional and ionic properties of a slow afterhyperpolarization in ferret perigeniculate neurons in vitro.
Topics: Action Potentials; Anesthetics, Local; Animals; Apamin; Bicuculline; Calcium; Calcium Channel Blockers; Excitatory Postsynaptic Potentials; Female; Ferrets; GABA Antagonists; gamma-Aminobutyric Acid; Geniculate Bodies; Lidocaine; Male; Neurons; omega-Conotoxin GVIA; Peptides; Periodicity; Potassium; Potassium Channels; Sodium; Tetraethylammonium; Tetrodotoxin | 1998 |
Synaptic activation of plateaus in hindlimb motoneurons of decerebrate cats.
Topics: Action Potentials; Anesthetics, Local; Animals; Cats; Decerebrate State; Differential Threshold; Electric Conductivity; Excitatory Postsynaptic Potentials; Hindlimb; Intracellular Membranes; Lidocaine; Male; Motor Neurons; Neural Inhibition; Physical Stimulation; Recruitment, Neurophysiological; Sodium; Synapses; Synaptic Transmission | 1998 |
Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel.
Topics: Amino Acid Sequence; Anesthetics, Local; Animals; Binding Sites; Cysteine; Cytoplasm; Electrophysiology; Indicators and Reagents; Ion Channel Gating; Kinetics; Lidocaine; Mesylates; Mice; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Oocytes; Protein Conformation; Receptors, Cholinergic; Xenopus | 1998 |
RINm5f cells express inactivating BK channels whereas HIT cells express noninactivating BK channels.
Topics: Action Potentials; Alternative Splicing; Anesthetics, Local; Animals; Calcium; Charybdotoxin; Cricetinae; Cytosol; Glucose; In Vitro Techniques; Insulinoma; Large-Conductance Calcium-Activated Potassium Channels; Lidocaine; Pancreatic Neoplasms; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Rats; RNA; Trypsin; Tumor Cells, Cultured | 1999 |
Cellular mechanisms underlying spontaneous interictal spikes in an acute model of focal cortical epileptogenesis.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Acute Disease; Animals; Bicuculline; Brain; Cerebral Cortex; Disease Models, Animal; Epilepsies, Partial; Functional Laterality; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Lidocaine; Membrane Potentials; Reaction Time; Synaptic Transmission | 1999 |
Action potentials in the dendrites of retinal ganglion cells.
Topics: Action Potentials; Animals; Dendrites; Lidocaine; Membrane Potentials; Patch-Clamp Techniques; Rabbits; Retinal Ganglion Cells | 1999 |
The first-order giant neurons of the giant fiber system in the squid: electrophysiological and ultrastructural observations.
Topics: Action Potentials; Anesthetics, Local; Animals; Axons; Cells, Cultured; Decapodiformes; Electric Stimulation; Escape Reaction; Evoked Potentials; In Vitro Techniques; Lidocaine; Nerve Fibers; Neurons; Synapses; Tetrodotoxin | 1998 |
Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons.
Topics: Animals; Cerebellar Cortex; Electric Stimulation; Excitatory Postsynaptic Potentials; Guinea Pigs; In Vitro Techniques; Interneurons; Lidocaine; Membrane Potentials; Nerve Net; Reaction Time; Synaptic Transmission; Tetrodotoxin | 1999 |
Synergistic inhibition of lysophosphatidic acid signaling by charged and uncharged local anesthetics.
Topics: Anesthetics, Local; Animals; Benzocaine; Chloride Channels; Dose-Response Relationship, Drug; Female; Guanosine 5'-O-(3-Thiotriphosphate); Lidocaine; Lysophospholipids; Protein Kinase C; Signal Transduction; Xenopus | 1999 |
Selective protection of gray and white matter during spinal cord ischemic injury.
Topics: Animals; Brain; Disease Models, Animal; Evaluation Studies as Topic; Excitatory Amino Acid Antagonists; Injections, Spinal; Ischemia; Lidocaine; Male; Paraplegia; Piperazines; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium Chloride; Spinal Cord; Time Factors | 1999 |
Reduced Mg2+ blockade of synaptically activated N-methyl-D-aspartate receptor-channels in CA1 pyramidal neurons in kainic acid-lesioned rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Lidocaine; Magnesium; Male; Models, Neurological; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reference Values; Synaptic Transmission | 1999 |
Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells.
Topics: Adrenal Glands; Amino Acid Sequence; Animals; Calcium; Charybdotoxin; Chromaffin Cells; Cytosol; Expressed Sequence Tags; Gene Expression; Humans; Insulinoma; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channel beta Subunits; Large-Conductance Calcium-Activated Potassium Channels; Lidocaine; Molecular Sequence Data; Oocytes; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Rats; RNA, Messenger; Sequence Homology, Amino Acid; Trypsin; Tumor Cells, Cultured; Xenopus laevis | 1999 |
Presynaptic inhibition preferentially reduces in NMDA receptor-mediated component of transmission in rat midbrain dopamine neurons.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baclofen; Cesium; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Agonists; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Mesencephalon; N-Methylaspartate; Neurons; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum.
Topics: Anesthetics, Local; Animals; Apamin; Bicuculline; Calcium Channels; Cerebellum; Egtazic Acid; Evoked Potentials; In Vitro Techniques; Indoles; Lidocaine; Membrane Potentials; Neurons; Neurotoxins; Patch-Clamp Techniques; Rats; Synaptic Transmission; Virulence Factors, Bordetella | 1999 |
Pharmacological isolation of the synaptic and nonsynaptic components of the GABA-mediated biphasic response in rat CA1 hippocampal pyramidal cells.
Topics: Adenosine Triphosphate; Anesthetics, Local; Animals; Evoked Potentials; Fluorides; GABA Antagonists; Hippocampus; In Vitro Techniques; Lidocaine; Male; Models, Neurological; Neurons; Organophosphorus Compounds; Phosphinic Acids; Propanolamines; Pyramidal Cells; Quinine; Rats; Rats, Wistar; Receptors, GABA-A; Synapses; Synaptic Transmission | 1999 |
Paradoxical effect of QX-314 on persistent inward currents and bistable behavior in spinal motoneurons in vivo.
Topics: Anesthetics, Local; Animals; Axons; Cats; Lidocaine; Motor Neurons; Muscle, Skeletal; Neural Conduction; Regression Analysis; Spinal Cord | 1999 |
Locus coeruleus neurones in vitro: pH-sensitive oscillations of membrane potential in an electrically coupled network.
Topics: Acidosis; Animals; Cadmium; Calcium; Cells, Cultured; Culture Media; Hydrogen-Ion Concentration; Hypercapnia; Lidocaine; Locus Coeruleus; Magnesium; Membrane Potentials; Neurons; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1999 |
Direct inhibition of microtubule-based kinesin motility by local anesthetics.
Topics: Adenosine Triphosphatases; Anesthetics, Local; Animals; Biological Transport; Biomechanical Phenomena; Brain; Carbocyanines; Cattle; Enzyme Inhibitors; Fluorescent Dyes; Humans; Kinesins; Kinetics; Lidocaine; Microscopy, Fluorescence; Microtubules; Mutation; Rhodamines; Tetracaine | 2000 |
Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Bicuculline; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indoles; Interneurons; Isoxazoles; Kainic Acid; Lidocaine; Maleimides; Naphthalenes; Nerve Tissue Proteins; Patch-Clamp Techniques; Propionates; Protein Kinase C; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Presynaptic; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 2000 |
Unveiling synaptic plasticity: a new graphical and analytical approach.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Baclofen; Cells, Cultured; Computer Graphics; Data Display; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agonists; Lidocaine; Mathematical Computing; Memory; Models, Neurological; Neuronal Plasticity; Neurons; Rats; Regression Analysis; Signal Processing, Computer-Assisted; Synapses | 2000 |
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.
Topics: Anesthetics, Local; Animals; Binding Sites; Lidocaine; Muscle, Skeletal; Mutagenesis; Myocardium; NAV1.8 Voltage-Gated Sodium Channel; Protein Isoforms; Rats; Sodium Channels; Tetrodotoxin; Xenopus | 2000 |
Evidence of elevated intracellular calcium levels in weaver homozygote mice.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cerebellum; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Homozygote; Lidocaine; Mice; Mice, Neurologic Mutants; Neurons; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Stimulation, Chemical | 2000 |
Spinal tonicaine: potency and differential blockade of sensory and motor functions.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Cells, Cultured; Injections, Spinal; Lidocaine; Male; Motor Neurons; Neuromuscular Blockade; Neurons, Afferent; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channels; Spinal Cord; Structure-Activity Relationship | 2000 |
Participation of low-threshold calcium spikes in excitatory synaptic transmission in guinea pig medial frontal cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Calcium; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Frontal Lobe; Guinea Pigs; In Vitro Techniques; Lidocaine; Membrane Potentials; N-Methylaspartate; Potassium Acetate; Pyramidal Cells; Synaptic Transmission | 2000 |
Modulation of pacemaker activity by salmon gonadotropin-releasing hormone (sGnRH) in terminal nerve (TN)-GnRH neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Biological Clocks; Brain; Cytoplasm; Dose-Response Relationship, Drug; Female; Fishes; Gonadotropin-Releasing Hormone; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Perfusion; Reaction Time; Salmon; Sodium Channel Blockers; Thionucleotides | 2000 |
Linear to supralinear summation of AMPA-mediated EPSPs in neocortical pyramidal neurons.
Topics: Anesthetics, Local; Animals; Dendrites; Electric Stimulation; Evoked Potentials; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Lidocaine; Linear Models; Male; Neocortex; Neural Conduction; Nonlinear Dynamics; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synapses | 2000 |
Ionic mechanisms underlying repetitive high-frequency burst firing in supragranular cortical neurons.
Topics: Action Potentials; Aging; Animals; Calcium; Chelating Agents; Cycloleucine; Egtazic Acid; Female; Ferrets; In Vitro Techniques; Lidocaine; Male; Neurons; Phenytoin; Potassium; Potassium Channels; Pyramidal Cells; Sodium; Sodium Channels; Tetrodotoxin; Visual Cortex | 2000 |
Local anesthetic inhibition of m1 muscarinic acetylcholine signaling.
Topics: Acetylcholine; Anesthetics, Local; Animals; Benzocaine; Binding Sites; Cells, Cultured; CHO Cells; Choline; Cricetinae; Electrophysiology; GTP-Binding Proteins; Lidocaine; Patch-Clamp Techniques; Quinuclidinyl Benzilate; Receptors, Muscarinic; Signal Transduction; Xenopus | 2000 |
State-dependent cross-inhibition between transmitter-gated cation channels.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Cells, Cultured; Ion Channel Gating; Lidocaine; Mutagenesis, Site-Directed; Neurons; Nicotinic Antagonists; Receptor Cross-Talk; Receptors, Nicotinic; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Recombinant Proteins; Synapses; Xenopus | 2000 |
Characterization of a hyperpolarization-activated inward current in Cajal-Retzius cells in rat neonatal neocortex.
Topics: Animals; Animals, Newborn; Barium; Cesium; Chlorides; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Extracellular Space; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Intracellular Fluid; Ion Channels; Lidocaine; Linear Models; Membrane Potentials; Neocortex; Patch-Clamp Techniques; Potassium; Potassium Channels; Rats; Rats, Wistar; Sodium | 2000 |
Quaternary ammonium block of mutant Na+ channels lacking inactivation: features of a transition-intermediate mechanism.
Topics: Algorithms; Anesthetics, Local; Animals; Electrophysiology; Ion Channel Gating; Kinetics; Lidocaine; Muscle, Skeletal; Mutation; Oocytes; Patch-Clamp Techniques; Protein Conformation; Quaternary Ammonium Compounds; Rats; Recombinant Proteins; Signal Transduction; Sodium Channel Blockers; Sodium Channels; Xenopus laevis | 2000 |
Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method.
Topics: Acetylcholine; Amino Acid Substitution; Animals; Cysteine; Ethyl Methanesulfonate; In Vitro Techniques; Ion Channel Gating; Lidocaine; Membrane Potentials; Mice; Models, Molecular; Muscle, Skeletal; Mutagenesis, Site-Directed; Oocytes; Protein Structure, Secondary; Protein Subunits; Receptors, Cholinergic; Recombinant Proteins; Xenopus | 2001 |
Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels.
Topics: Anesthetics, Local; Animals; Barium; Binding Sites; Biophysical Phenomena; Biophysics; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; In Vitro Techniques; Ion Channel Gating; Kinetics; Lidocaine; Mutation; Oocytes; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Recombinant Fusion Proteins; Xenopus | 2001 |
Local anesthetic inhibition of G protein-coupled receptor signaling by interference with Galpha(q) protein function.
Topics: Amides; Anesthetics, Local; Animals; Binding Sites; Drug Interactions; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Lidocaine; Lysophospholipids; Oligonucleotides, Antisense; Oocytes; Receptor, Angiotensin, Type 1; Receptor, Muscarinic M1; Receptors, Angiotensin; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Receptors, Muscarinic; Ropivacaine; Signal Transduction; Trypsin; Xenopus laevis | 2001 |
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.
Topics: Amino Acid Substitution; Anesthetics, Local; Animals; Calcium Channel Blockers; Cells, Cultured; Conotoxins; Ethyl Methanesulfonate; Ion Channel Gating; Lidocaine; Mesylates; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Rats; Saxitoxin; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship; Tetrodotoxin; Transfection; Xenopus laevis | 2001 |
Potentiation of sensory responses in the anterior cingulate cortex following digit amputation in the anaesthetised rat.
Topics: Amputation, Surgical; Anesthesia; Anesthetics, Local; Animals; Electroshock; Excitatory Postsynaptic Potentials; Gyrus Cinguli; Lidocaine; Male; Neuronal Plasticity; Neurons, Afferent; Nociceptors; Phantom Limb; Rats; Rats, Sprague-Dawley; Synapses | 2001 |
Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics.
Topics: Anesthetics, Local; Animals; Benzocaine; CHO Cells; Cricetinae; Female; Heterotrimeric GTP-Binding Proteins; Inhibitory Concentration 50; Lidocaine; Models, Biological; Muscarinic Antagonists; Oocytes; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Xenopus laevis | 2001 |
Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics.
Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Dogs; Kidney Medulla; Lidocaine; Mepivacaine; Procaine; Protein Binding; Ropivacaine; Sodium Channels; Sodium-Potassium-Exchanging ATPase | 2001 |
Enhanced temporal stability of cholinergic hippocampal gamma oscillations following respiratory alkalosis in vitro.
Topics: 2-Amino-5-phosphonovalerate; Alkalosis, Respiratory; Animals; Carbachol; Carbon Dioxide; Cholinergic Fibers; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Hippocampus; Hydrogen-Ion Concentration; Lidocaine; Male; Methylamines; Midazolam; Nerve Tissue Proteins; Pentobarbital; Periodicity; Phosphinic Acids; Propanolamines; Quinoxalines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Time Factors | 2001 |
Ionic mechanisms underlying burst firing of layer III sensorimotor cortical neurons of the cat: an in vitro slice study.
Topics: Action Potentials; Anesthetics, Local; Animals; Apamin; Calcium; Calcium Channel Blockers; Cats; Chelating Agents; Egtazic Acid; Electrophysiology; Lidocaine; Manganese; Motor Cortex; Neurons; Organ Culture Techniques; Periodicity; Sodium; Somatosensory Cortex; Tetraethylammonium; Tetrodotoxin | 2001 |
Function of NMDA receptors and persistent sodium channels in a feedback pathway of the electrosensory system.
Topics: Anesthetics, Local; Animals; Antibodies; Brain Chemistry; Electric Fish; Electric Organ; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback; GABA Antagonists; Immunoblotting; Immunohistochemistry; Lidocaine; Piperazines; Pyramidal Cells; Pyridazines; Rabbits; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Tetrodotoxin | 2001 |
Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortex.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Cadmium; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Ion Channel Gating; Lidocaine; Male; Nickel; Organ Culture Techniques; Potassium Channel Blockers; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium Channels; Synapses; Tetraethylammonium; Tetrodotoxin | 2001 |
Electrophysiology of interneurons in the glomerular layer of the rat olfactory bulb.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthetics, Local; Animals; Cell Size; Choline; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Interneurons; Lidocaine; Male; Nickel; Nootropic Agents; Olfactory Bulb; Patch-Clamp Techniques; Periodicity; Quinoxalines; Rats; Rats, Sprague-Dawley | 2001 |
Development of a behavioral model of TMJ pain in rats: the TMJ formalin test.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Disease Models, Animal; Lidocaine; Male; Morphine; Nociceptors; Pain; Pain Measurement; Rats; Rats, Wistar; Temporomandibular Joint | 2001 |
Inhibition of wild-type and mutant neuronal nicotinic acetylcholine receptors by local anesthetics.
Topics: Anesthetics, Local; Animals; Electrophysiology; Lidocaine; Membrane Proteins; Mutation; Nicotinic Antagonists; Oocytes; Receptors, Nicotinic; Tetracaine; Xenopus laevis | 2001 |
Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.
Topics: Action Potentials; Anesthetics, Local; Animals; Biological Clocks; Cortical Spreading Depression; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Fever; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Kynurenic Acid; Lidocaine; Neurons; Rats; Rats, Sprague-Dawley; Seizures, Febrile; Synaptic Transmission | 2001 |
Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats.
Topics: Amiloride; Anesthetics, Local; Animals; Blood Gas Analysis; Body Fluids; Diuretics; Epithelium; Hemodynamics; Injections; Injections, Intravenous; Lidocaine; Male; Oocytes; Proteins; Pulmonary Alveoli; Pulmonary Gas Exchange; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Sodium Channels; Xenopus | 2002 |
Intracellular QX-314 causes depression of membrane potential oscillations in lamprey spinal neurons during fictive locomotion.
Topics: Action Potentials; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Glutamic Acid; In Vitro Techniques; Lidocaine; Locomotion; Neural Inhibition; Neurons; Patch-Clamp Techniques; Periodicity; Sodium; Spinal Cord | 2002 |
Effects of QX-314 on membrane properties of neurons in the ventrobasal thalamus.
Topics: Anesthetics, Local; Animals; Calcium Signaling; Cell Membrane; Lidocaine; Membrane Potentials; Microscopy, Video; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Ventral Thalamic Nuclei | 2002 |
High frequency stimulation-induced dendritic calcium waves in rat hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Benzoates; Calcium; Calcium Signaling; Dendrites; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glycine; Hippocampus; In Vitro Techniques; Lidocaine; Male; Microscopy, Confocal; N-Methylaspartate; Neurons; Organic Chemicals; Rats; Rats, Wistar | 2002 |
Postnatal changes in the overall postsynaptic currents evoked in CA1 pyramidal neurons of the rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; In Vitro Techniques; Lidocaine; Male; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar | 2002 |
Independent neuronal oscillators of the rat globus pallidus.
Topics: Action Potentials; Anesthetics, Local; Animals; Bicuculline; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Lidocaine; Methoxyhydroxyphenylglycol; Neurons; Organ Culture Techniques; Periodicity; Rats; Rats, Wistar | 2003 |
Functional significance of cannabinoid-mediated, depolarization-induced suppression of inhibition (DSI) in the hippocampus.
Topics: Action Potentials; Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Colforsin; Electric Stimulation; Enzyme Activators; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lidocaine; Male; Marine Toxins; Morpholines; Naphthalenes; Neural Inhibition; omega-Conotoxin GVIA; Oxazoles; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA-A; Sodium Channel Blockers | 2003 |
Voltage-gated Na+ channels enhance the temporal filtering properties of electrosensory neurons in the torus.
Topics: Action Potentials; Animals; Electrophysiology; Excitatory Postsynaptic Potentials; Gymnotiformes; Lidocaine; Neurons, Afferent; Sodium Channel Blockers; Sodium Channels | 2003 |
Local anaesthetics block hyperpolarization-activated inward current in rat small dorsal root ganglion neurones.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Electrophysiology; Ganglia, Spinal; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Inhibitory Concentration 50; Ion Channels; Lidocaine; Mepivacaine; Neurons; Potassium Channels; Pyrimidines; Rats; Tetraethylammonium; Time Factors | 2003 |
Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amphetamines; Animals; Bicuculline; Fluorobenzenes; GABA-A Receptor Antagonists; Glutamic Acid; Indoles; Lidocaine; Male; Patch-Clamp Techniques; Phenols; Pindolol; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Sodium Channel Blockers; Sulfonamides; Synapses; Tetrodotoxin; Time Factors | 2004 |
Contribution of intrinsic neuronal factors in the generation of cortically driven electrographic seizures.
Topics: Action Potentials; Anesthetics, Local; Animals; Calcium Channels; Cats; Cerebral Cortex; Cesium; Chelating Agents; Cortical Synchronization; Egtazic Acid; Electroencephalography; Electrophysiology; Lidocaine; Membrane Potentials; Neurons; Potassium Channels; Seizures; Sodium Channels | 2004 |
Voltage-dependent enhancement of electrical coupling by a subthreshold sodium current.
Topics: Animals; Auditory Pathways; Escape Reaction; Evoked Potentials; Goldfish; Lidocaine; Models, Neurological; Neurons; Potassium Channel Blockers; Presynaptic Terminals; Sodium Channel Blockers; Sodium Channels; Synaptic Transmission; Tetrodotoxin; Vestibulocochlear Nerve | 2004 |
NMDA receptor-mediated depolarizing after-potentials in the basal dendrites of CA1 pyramidal neurons.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Dendrites; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Antagonists; Gallopamil; Hippocampus; Lidocaine; Male; Models, Neurological; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Statistics, Nonparametric; Valine | 2004 |
Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.
Topics: Amino Acid Substitution; Anti-Arrhythmia Agents; Heart; Humans; Leucine; Lidocaine; Mexiletine; Mutation; Myocardium; Serine; Sodium Channel Blockers; Sodium Channels | 2004 |
Membrane bistability in thalamic reticular neurons during spindle oscillations.
Topics: Action Potentials; Anesthetics, Local; Animals; Biotin; Cats; Computer Simulation; Dose-Response Relationship, Radiation; Electric Stimulation; Electroencephalography; Evoked Potentials; Excitatory Postsynaptic Potentials; Intralaminar Thalamic Nuclei; Lidocaine; Membrane Potentials; Neural Pathways; Neurons; Patch-Clamp Techniques; Periodicity; Synapses; Time Factors | 2005 |
Local anesthetics inhibit thromboxane A2 signaling in Xenopus oocytes and human k562 cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthetics, Local; Animals; Calcium; Female; Humans; K562 Cells; Lidocaine; Oocytes; Signal Transduction; Thromboxane A2; Xenopus | 2004 |
The cortically evoked secondary depolarization affects the integrative properties of thalamic reticular neurons.
Topics: Anesthetics, Local; Animals; Cats; Cerebral Cortex; Dose-Response Relationship, Radiation; Efferent Pathways; Electric Stimulation; Excitatory Postsynaptic Potentials; Lidocaine; Membrane Potentials; Neurons; Thalamus; Time Factors | 2004 |
Synaptic depolarizing GABA Response in adults is excitatory and proconvulsive when GABAB receptors are blocked.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Drug Interactions; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Potassium Channel Blockers; Propanolamines; Pyridazines; Receptors, GABA-A; Synaptic Transmission | 2005 |
Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis; Carrageenan; Disease Models, Animal; Down-Regulation; Lidocaine; Male; Nociceptors; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X; Sensory Receptor Cells; Temporomandibular Joint; Temporomandibular Joint Disorders | 2005 |
[The filter region of the myocardial Na channel, together with ion selectivity, controls pharmacodynamics of anti-arrhythmia agents--an analysis using the channel altered by idiopathic ventricular fibrillation].
Topics: Anti-Arrhythmia Agents; Filtration; Heart; Humans; In Vitro Techniques; Lidocaine; Mexiletine; Muscle Proteins; NAV1.5 Voltage-Gated Sodium Channel; Sodium Channels; Ventricular Fibrillation | 2004 |
Presenilin attenuates receptor-mediated signaling and synaptic function.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Carbazoles; Cell Adhesion Molecules; Cell Line, Tumor; Cell Membrane; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DCC Receptor; Dipeptides; Endopeptidases; Excitatory Postsynaptic Potentials; Genes, DCC; Glutamic Acid; Indoles; Lidocaine; Membrane Proteins; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurites; Neuroblastoma; Neurons; Piperazines; Presenilin-1; Protein Processing, Post-Translational; Pyrroles; Quinoxalines; Rats; Receptors, Cell Surface; Recombinant Fusion Proteins; Second Messenger Systems; Synaptic Transmission; Transfection; Tumor Suppressor Proteins | 2005 |
Sodium channels in transient retinal bipolar cells enhance visual responses in ganglion cells.
Topics: Ambystoma; Animals; Choline; Dendrites; Interneurons; Ion Channel Gating; Larva; Lidocaine; Patch-Clamp Techniques; Photic Stimulation; Photoreceptor Cells, Vertebrate; Retinal Ganglion Cells; Sodium; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Time Factors; Visual Pathways | 2005 |
Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue.
Topics: Animals; Cadmium; Cell Line; Extracellular Fluid; Ganglia, Spinal; Humans; Intracellular Fluid; Lidocaine; Male; Neurons, Afferent; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Saxitoxin; Serine; Sodium; Sodium Channels; Tetrodotoxin | 2005 |
Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Aminobutyrates; Anesthetics, Local; Animals; Animals, Newborn; Cyclopropanes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Globus Pallidus; Glycine; In Vitro Techniques; Lidocaine; Membrane Potentials; Methoxyhydroxyphenylglycol; Neurons; Patch-Clamp Techniques; Proline; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sulfonamides; Synaptic Transmission; Xanthenes | 2005 |
Behaviorally relevant endocannabinoid action in hippocampus: dependence on temporal summation of multiple inputs.
Topics: Action Potentials; Animals; Behavior, Animal; Calcium; Calcium Channel Blockers; Calcium Signaling; Cannabinoid Receptor Modulators; Endocannabinoids; Excitatory Postsynaptic Potentials; Hippocampus; Lidocaine; Male; omega-Conotoxin GVIA; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2005 |
Dynamics of excitation and inhibition underlying stimulus selectivity in rat somatosensory cortex.
Topics: Action Potentials; Anesthetics, Local; Animals; Electric Conductivity; Electric Stimulation; Lidocaine; Male; Neural Inhibition; Neurons; Nonlinear Dynamics; Rats; Rats, Sprague-Dawley; Reaction Time; Somatosensory Cortex; Synapses; Time Factors; Vibrissae | 2005 |
NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Genes, Reporter; Glutamic Acid; Lac Operon; Lidocaine; Magnesium; Membrane Potentials; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Promoter Regions, Genetic; Protein Subunits; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Somatosensory Cortex; Synapses; Synaptic Transmission; Tetrodotoxin | 2006 |
Olfactory nerve stimulation-evoked mGluR1 slow potentials, oscillations, and calcium signaling in mouse olfactory bulb mitral cells.
Topics: Animals; Animals, Newborn; Aspartic Acid; Calcium Channel Blockers; Calcium Signaling; Diagnostic Imaging; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Imidazoles; In Vitro Techniques; Lidocaine; Mice; Mice, Inbred ICR; Neurons; Olfactory Bulb; Olfactory Nerve; Pyridazines; Receptors, Metabotropic Glutamate; Sodium Channel Blockers | 2006 |
Effects of systemic administration of lidocaine and QX-314 on hyperexcitability of spinal dorsal horn neurons after incision in the rat.
Topics: Action Potentials; Anesthetics, Local; Animals; Denervation; Dose-Response Relationship, Drug; Hyperalgesia; Lidocaine; Male; Pain, Postoperative; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2006 |
Impaired feedforward inhibition of the thalamocortical projection in epileptic Ca2+ channel mutant mice, tottering.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Age Factors; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy, Absence; Evoked Potentials; Excitatory Postsynaptic Potentials; Homeostasis; Lidocaine; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Picrotoxin; Pyramidal Cells; Somatosensory Cortex; Synaptic Transmission; Thalamic Nuclei; Valine | 2006 |
The wave phenomena in smooth muscle syncytia.
Topics: Algorithms; Animals; Biomechanical Phenomena; Calcium; Cholinergic Antagonists; Digestive System; Digestive System Physiological Phenomena; Giant Cells; Humans; Ion Channels; Lidocaine; Mathematics; Models, Biological; Muscle, Smooth; Neuromuscular Junction | 2005 |
An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Animals, Newborn; Aspartic Acid; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Lidocaine; Magnesium; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetrodotoxin | 2006 |
Pharmacology of a slowly inactivating outward current in hippocampal CA3 pyramidal neurons.
Topics: Animals; Calcium; Cations, Divalent; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Patch-Clamp Techniques; Potassium; Pyramidal Cells; Pyrimidines | 2006 |
Dendritic calcium spikes induce bi-directional synaptic plasticity in the lateral amygdala.
Topics: Action Potentials; Amygdala; Anesthetics, Local; Animals; Calcium; Calcium Channel Blockers; Dendrites; Electric Stimulation; Excitatory Postsynaptic Potentials; In Vitro Techniques; Lidocaine; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neuronal Plasticity; Neurons; Nickel; Patch-Clamp Techniques; Reaction Time; Spider Venoms; Synapses; Verapamil | 2007 |
Non-Gaussian membrane potential dynamics imply sparse, synchronous activity in auditory cortex.
Topics: Acoustic Stimulation; Anesthetics, Local; Animals; Animals, Newborn; Auditory Cortex; Cortical Synchronization; Electric Stimulation; Lidocaine; Membrane Potentials; Models, Neurological; Neural Inhibition; Neurons; Nonlinear Dynamics; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Time Factors; Wakefulness | 2006 |
Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Electric Stimulation; Excitatory Postsynaptic Potentials; Gyrus Cinguli; In Vitro Techniques; Lidocaine; Long-Term Synaptic Depression; Male; Membrane Potentials; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neuronal Plasticity; Oligopeptides; Patch-Clamp Techniques; Protein Structure, Tertiary; Pyramidal Cells; Receptors, AMPA; Synaptic Transmission; Time Factors | 2007 |
Involvement of persistent Na+ current in spike initiation in primary sensory neurons of the rat mesencephalic trigeminal nucleus.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Lidocaine; Neurons, Afferent; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Riluzole; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Trigeminal Nuclei | 2007 |
Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation.
Topics: Anesthetics, Local; Animals; Biological Clocks; Inhalation; Lidocaine; Medulla Oblongata; Mice; Mice, Inbred C57BL; Microinjections; Neurons; Sodium | 2007 |
The quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivo.
Topics: Action Potentials; Anesthesia, Local; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Intradermal Tests; Lidocaine; Mice; Nerve Block; Pain; Pain Measurement; Quaternary Ammonium Compounds; Random Allocation; Sciatic Nerve; Sciatic Neuropathy; Sodium Chloride; Survival Analysis; Time Factors | 2007 |
Neuroscience: a local route to pain relief.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Capsaicin; Cell Membrane Permeability; Electric Conductivity; Humans; Lidocaine; Nociceptors; Pain; Sodium; Sodium Channel Blockers; TRPV Cation Channels | 2007 |
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Capsaicin; Cell Membrane Permeability; Electric Conductivity; Ganglia, Spinal; Lidocaine; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; TRPV Cation Channels | 2007 |
Chillies: out of the frying pan and into the clinic?
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Capsaicin; Drug Interactions; Humans; Lidocaine; Pain; Rats; TRPV Cation Channels | 2007 |
Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels.
Topics: Amino Acids, Aromatic; Anesthetics, Local; Animals; Benzocaine; Binding Sites; Humans; Lidocaine; Muscle Proteins; NAV1.4 Voltage-Gated Sodium Channel; Oocytes; Sodium Channel Blockers; Sodium Channels; Static Electricity; Transfection; Xenopus | 2008 |
Lidocaine increases intracellular sodium concentration through a Na+-H+ exchanger in an identified Lymnaea neuron.
Topics: Amiloride; Anesthetics, Local; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Lidocaine; Lymnaea; Mepivacaine; Microscopy, Fluorescence; Neurons; Prilocaine; Sodium; Sodium-Hydrogen Exchangers; Up-Regulation | 2008 |
Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem.
Topics: Acoustic Stimulation; Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Auditory Pathways; Baclofen; Dose-Response Relationship, Drug; Ear; Egtazic Acid; Electric Stimulation; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Gerbillinae; In Vitro Techniques; Lidocaine; Models, Molecular; Neural Inhibition; Neurons; Olivary Nucleus; Organophosphorus Compounds; Patch-Clamp Techniques; Receptors, GABA-B; Sound Localization; Synaptic Transmission | 2008 |
Access and binding of local anesthetics in the closed sodium channel.
Topics: Anesthetics, Local; Binding Sites; Cocaine; Computer Simulation; Conotoxins; Lidocaine; Ligands; Models, Biological; Models, Molecular; Molecular Structure; Monte Carlo Method; Mutation; Protein Conformation; Sodium; Sodium Channels; Static Electricity; Tetracaine; Tetrodotoxin; Water | 2008 |
Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Dipyrone; Dose-Response Relationship, Drug; Lidocaine; Morphine; Mustard Plant; Pain; Plant Oils; Rats; Temporomandibular Joint; Tramadol | 2009 |
Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.
Topics: Action Potentials; Animals; Disks Large Homolog 4 Protein; Electric Stimulation; Excitatory Postsynaptic Potentials; Guanylate Kinases; Hippocampus; Intracellular Signaling Peptides and Proteins; Lidocaine; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Patch-Clamp Techniques; Pyramidal Cells; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synaptic Transmission | 2008 |
Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior.
Topics: Acoustic Stimulation; Anesthetics, Local; Animals; Behavior, Animal; Benzylamines; Biotin; Chromatography, High Pressure Liquid; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Inhibition, Psychological; Lidocaine; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Psychomotor Performance; Quinoxalines; Racemases and Epimerases; Rotarod Performance Test; Space Perception | 2009 |
Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Kinetics; Lidocaine; Models, Biological; Muscle Proteins; Patch-Clamp Techniques; Protein Structure, Tertiary; Rats; Sodium Channel Blockers; Sodium Channels; Xenopus | 2009 |
Postsynaptic action potentials are required for nitric-oxide-dependent long-term potentiation in CA1 neurons of adult GluR1 knock-out and wild-type mice.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Biophysics; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitroarginine; Receptors, AMPA; Synaptic Potentials; Tetrodotoxin | 2008 |
Pore dilation occurs in TRPA1 but not in TRPM8 channels.
Topics: Aldehydes; Allyl Compounds; Anesthetics, Local; Animals; Benzamides; Benzoxazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Carbamates; Cells, Cultured; HeLa Cells; Humans; Ion Channel Gating; Lidocaine; Membrane Potentials; Movement; Nerve Tissue Proteins; Porins; Quinolinium Compounds; Rats; Thiocyanates; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels | 2009 |
Involvement of nicotinic and muscarinic receptors in the endogenous cholinergic modulation of the balance between excitation and inhibition in the young rat visual cortex.
Topics: Acetylcholine; Aconitine; Animals; Cerebral Cortex; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Lidocaine; Luminescent Measurements; Membrane Potentials; Neural Conduction; Neural Inhibition; Neural Pathways; Neurons; Neurosecretion; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission; Visual Cortex | 2009 |
Homeostatic presynaptic suppression of neuronal network bursts.
Topics: Action Potentials; Anesthetics, Local; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; Green Fluorescent Proteins; Hippocampus; Inhibitory Postsynaptic Potentials; Lidocaine; N-Methylaspartate; Nerve Net; Neurons; Presynaptic Terminals; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptosomal-Associated Protein 25; Tetrodotoxin; Time Factors; Transfection; Valine; Vesicle-Associated Membrane Protein 2 | 2009 |
Glycine site of NMDA receptor serves as a spatiotemporal detector of synaptic activity patterns.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Biophysics; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Glial Fibrillary Acidic Protein; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Lidocaine; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synapses; Time Factors; Tubulin; Valine | 2009 |
Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents.
Topics: Animals; Cells, Cultured; Drug Therapy, Combination; Lidocaine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain Measurement; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Time Factors | 2009 |
QX-314 produces long-lasting local anesthesia modulated by transient receptor potential vanilloid receptors in mice.
Topics: Anesthetics, Local; Animals; Female; Lidocaine; Mice; Pain Measurement; Time Factors; TRPV Cation Channels | 2009 |
N-ethyl lidocaine (QX-314) protects striatal neurons against ischemia: an in vitro electrophysiological study.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Cerebral Cortex; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Microelectrodes; Neostriatum; Neural Pathways; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Sodium; Sodium Channel Blockers | 2010 |
Prolonged sensory-selective nerve blockade.
Topics: Anesthetics, Local; Animals; Drug Interactions; Injections, Subcutaneous; Lidocaine; Male; Nerve Block; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensory Receptor Cells; Surface-Active Agents | 2010 |
Selectively targeting pain in the trigeminal system.
Topics: Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Capsaicin; Electric Stimulation; Lidocaine; Mice; Mice, Knockout; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Reflex; Trigeminal Ganglion; TRPV Cation Channels | 2010 |
Asymmetric rostro-caudal inhibition in the primary olfactory cortex.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lidocaine; Nerve Net; Neural Inhibition; Olfactory Pathways; Patch-Clamp Techniques; Photolysis; Pyramidal Cells; Rats; Terphenyl Compounds | 2010 |
Active roles of electrically coupled bipolar cell network in the adult retina.
Topics: Action Potentials; Adaptation, Ocular; Anesthetics, Local; Animals; Axons; Biophysical Phenomena; Biophysics; Biotin; Calcium; Connexins; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; Gap Junctions; Glycine Agents; Goldfish; In Vitro Techniques; Lidocaine; Nerve Net; Patch-Clamp Techniques; Picrotoxin; Propionates; Protein Kinase C-alpha; Retina; Retinal Bipolar Cells; Sodium; Strychnine; Synaptic Potentials | 2010 |
Lumbar intrathecal administration of the quaternary lidocaine derivative, QX-314, produces irritation and death in mice.
Topics: Akathisia, Drug-Induced; Animals; Dose-Response Relationship, Drug; Double-Blind Method; Female; Injections, Spinal; Lidocaine; Lumbosacral Region; Mice; Pruritus; Random Allocation | 2010 |
Long-term self-renewable feeder-free human induced pluripotent stem cell-derived neural progenitors.
Topics: Antigens, Differentiation; Calcium Channel Blockers; Cell Culture Techniques; Cell Differentiation; Cell Line; Cell Shape; Cryopreservation; Gene Expression Profiling; Humans; Induced Pluripotent Stem Cells; Intermediate Filament Proteins; Lidocaine; Membrane Potentials; Nerve Tissue Proteins; Nestin; Neural Stem Cells; Neurons; Nifedipine; Potassium Channel Blockers; SOXB1 Transcription Factors; Tetraethylammonium; Transcription, Genetic | 2011 |
Characterization of dental nociceptive neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Capsaicin; Cells, Cultured; Fluorescent Dyes; Lidocaine; NAV1.8 Voltage-Gated Sodium Channel; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X2; Receptors, Purinergic P2X3; Reverse Transcriptase Polymerase Chain Reaction; Sensory System Agents; Sodium Channel Blockers; Sodium Channels; Tooth; Toothache; Transient Receptor Potential Channels; Trigeminal Ganglion | 2011 |
A comparison of the systemic toxicity of lidocaine versus its quaternary derivative QX-314 in mice.
Topics: Anesthetics, Local; Animals; Central Nervous System Diseases; Dose-Response Relationship, Drug; Electrocardiography; Heart Diseases; Injections, Intravenous; Lidocaine; Mice | 2011 |
Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review.
Topics: Analgesics; Animals; Drug Delivery Systems; Lidocaine; Male; Nociceptors; Pain; Rats; Sensory Receptor Cells; Sodium Channel Blockers; TRPV Cation Channels | 2011 |
Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmission.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Lidocaine; Male; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Polyamines; Receptors, AMPA; Tetrodotoxin; Valine | 2011 |
Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes.
Topics: Acetylcholine; Anesthetics, Local; Animals; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Dose-Response Relationship, Drug; Drug Synergism; Edrophonium; Female; In Vitro Techniques; Ion Channel Gating; Lidocaine; Membrane Potentials; Nicotinic Antagonists; Oocytes; Receptors, Nicotinic; Torpedo; Xenopus laevis | 2011 |
The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro.
Topics: Animals; Female; Humans; Lidocaine; Transient Receptor Potential Channels; TRPV Cation Channels; Xenopus laevis | 2011 |
Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.
Topics: Adaptation, Physiological; Animals; Animals, Newborn; Axons; Cell Adhesion Molecules; Cells, Cultured; Coculture Techniques; Collagen Type VII; Epidermolysis Bullosa, Junctional; Ganglia, Spinal; Growth Cones; Humans; Kalinin; Keratinocytes; Lidocaine; Mechanotransduction, Cellular; Membrane Potentials; Mice; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Neurofilament Proteins; Patch-Clamp Techniques; Physical Stimulation; Reaction Time; Sensory Receptor Cells; Skin; Sodium Channel Blockers; Tetrodotoxin; Time Factors; TRPV Cation Channels; Ubiquitin Thiolesterase | 2011 |
Activation of TRPA1 by membrane permeable local anesthetics.
Topics: Anesthetics, Local; Animals; Ankyrins; Calcium; Calcium Channels; Cell Membrane Permeability; HEK293 Cells; Humans; Intracellular Space; Ion Channel Gating; Lidocaine; Mice; Mustard Plant; Mutant Proteins; Nerve Tissue Proteins; Plant Oils; Rats; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels | 2011 |
Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus.
Topics: Acoustic Stimulation; Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Auditory Pathways; Biophysics; Calcium; Calcium Channel Blockers; Cyclic Nucleotide-Gated Cation Channels; Electric Stimulation; Female; Gene Expression Regulation, Developmental; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Lidocaine; Mibefradil; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nerve Net; Neural Inhibition; Neurons; Olivary Nucleus; Periodicity; Potassium Channels; Psychoacoustics; Pyrimidines; Reaction Time; Sound; Tetrodotoxin | 2011 |
α7-Containing and non-α7-containing nicotinic receptors respond differently to spillover of acetylcholine.
Topics: Acetylcholine; Aconitine; Anesthetics, Local; Animals; Biophysical Phenomena; Cadmium Chloride; Calcium Channel Blockers; Chick Embryo; Cholinesterase Inhibitors; Conotoxins; Echothiophate Iodide; Excitatory Postsynaptic Potentials; Female; Ganglia, Parasympathetic; Lidocaine; Male; Models, Biological; Neurons; Nicotinic Antagonists; omega-Conotoxin GVIA; Patch-Clamp Techniques; Protein Subunits; Receptors, Nicotinic; Time Factors | 2011 |
Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects.
Topics: Acids; Analgesics; Animals; Blotting, Western; Ganglia, Spinal; Immunohistochemistry; Lidocaine; Male; Mice; Nociceptors; Patch-Clamp Techniques; Rats, Sprague-Dawley; Sodium Channel Blockers; Solutions; TRPV Cation Channels | 2011 |
Delayed treatment with lidocaine reduces mouse microglial cell injury and cytokine production after stimulation with lipopolysaccharide and interferon γ.
Topics: Anesthetics, Local; Animals; Cells, Cultured; Cytokines; Cytoprotection; Dose-Response Relationship, Drug; Interferon-gamma; L-Lactate Dehydrogenase; Lidocaine; Lipopolysaccharides; Mice; Microglia | 2012 |
Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Anesthetics, Local; Animals; Animals, Newborn; Biophysics; CA1 Region, Hippocampal; Corpus Striatum; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Interneurons; Lidocaine; Male; Neural Pathways; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium Channel Blockers; Synapses; Synaptic Potentials; Tetrodotoxin | 2012 |
The generation of direction selectivity in the auditory system.
Topics: Action Potentials; Anesthetics, Local; Animals; Auditory Pathways; Biotin; Cesium; Cochlear Nucleus; Electric Stimulation; Female; Inferior Colliculi; Lidocaine; Patch-Clamp Techniques; Photic Stimulation; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sound Localization; Space Perception; Synaptic Transmission; Tetraethylammonium; Thalamus | 2012 |
Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action.
Topics: Acetanilides; Animals; Biomechanical Phenomena; Cells, Cultured; Enzyme Inhibitors; HEK293 Cells; Humans; Kidney; Lidocaine; Mice; Mice, Inbred C57BL; Models, Animal; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Piperazines; Ranolazine; Sodium Channels; Transfection | 2012 |
Frequency-dependent amplification of stretch-evoked excitatory input in spinal motoneurons.
Topics: Anesthetics, Local; Animals; Cats; Excitatory Postsynaptic Potentials; Lidocaine; Membrane Potentials; Motor Neurons; Muscle Stretching Exercises; Muscle, Skeletal; Sodium Channels; Spinal Cord | 2012 |
Local anesthetic inhibition of a bacterial sodium channel.
Topics: Acetanilides; Anesthetics, Local; Bacillus; Benzocaine; Binding Sites; Cell Line, Transformed; Cytoplasm; Eukaryota; HEK293 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Ion Channel Gating; Kinetics; Lidocaine; Piperazines; Ranolazine; Sodium; Sodium Channels | 2012 |
Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats.
Topics: Anesthetics, Local; Animals; Antipruritics; Capsaicin; Disease Models, Animal; Drug Administration Routes; Drug Therapy, Combination; Hyperalgesia; Lidocaine; Male; Neuralgia; Peripheral Nerves; Rats; Rats, Sprague-Dawley | 2012 |
Use of escin as a perforating agent on the IonWorks quattro automated electrophysiology platform.
Topics: Amphotericin B; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; CHO Cells; Cricetinae; Drug Evaluation, Preclinical; Escin; HEK293 Cells; Humans; Ionophores; Lidocaine; Reference Standards | 2013 |
Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation.
Topics: Anesthetics, Local; Animals; Capsaicin; Gene Expression; Hyperalgesia; Lidocaine; Male; Mandibular Nerve; Myelin Sheath; Nerve Regeneration; Neuralgia; Nociceptors; Pain Management; Pain Threshold; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; Trigeminal Nerve Injuries; TRPV Cation Channels | 2012 |
Overinhibition of corticostriatal activity following prenatal cocaine exposure.
Topics: Age Factors; Analysis of Variance; Anesthetics, Local; Animals; Biophysics; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Female; GABA Agents; Green Fluorescent Proteins; Hindlimb Suspension; In Vitro Techniques; Interneurons; Lidocaine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neural Inhibition; Neuronal Plasticity; Patch-Clamp Techniques; Pregnancy; Prenatal Exposure Delayed Effects; Quinoxalines; Quinpirole; Receptors, GABA-A; Rotarod Performance Test; Sodium Channel Blockers; Statistics, Nonparametric; Tetrodotoxin | 2013 |
Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.
Topics: Action Potentials; Anesthetics, Local; Animals; Axons; Behavior, Animal; Capsaicin; Chronic Pain; Disease Models, Animal; Lidocaine; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensory Receptor Cells; TRPV Cation Channels | 2013 |
Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314.
Topics: Action Potentials; Animals; Capsaicin; Cell Line, Tumor; Cesium; Connexins; Ganglia, Spinal; Humans; Ion Transport; Lidocaine; Rats; Rats, Sprague-Dawley; Sodium; TRPV Cation Channels | 2013 |
Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytes.
Topics: Animals; Gene Expression; Kinetics; Lidocaine; Oocytes; Quaternary Ammonium Compounds; TRPV Cation Channels; Xenopus laevis; Xenopus Proteins | 2013 |
Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus.
Topics: Anesthetics, Local; Animals; Animals, Newborn; CA1 Region, Hippocampal; Cyclic GMP; Electric Stimulation; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Mice; Mice, Knockout; Neurons; Nitric Oxide; Patch-Clamp Techniques; Pyrimidines; Receptors, N-Methyl-D-Aspartate; Tetraethylammonium | 2014 |
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Biophysics; Calcium; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Feedback, Physiological; GABA Antagonists; gamma-Aminobutyric Acid; Green Fluorescent Proteins; In Vitro Techniques; Lidocaine; Lysine; Male; Mice; Mice, Transgenic; Monte Carlo Method; Neostriatum; Neural Inhibition; Neural Pathways; Neurons; Oxidopamine; Parkinsonian Disorders; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Wistar; Reaction Time; Receptors, Dopamine D1; Receptors, Dopamine D2; Synaptic Transmission; Time Factors; Valine | 2013 |
PKC activation during training restores mushroom spine synapses and memory in the aged rat.
Topics: Aging; Anesthetics, Local; Animals; Brain-Derived Neurotrophic Factor; Bryostatins; Caprylates; Dendrites; ELAV Proteins; ELAV-Like Protein 4; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lidocaine; Maze Learning; Memory; Patch-Clamp Techniques; Protein Kinase C; Pyramidal Cells; Rats; Synapses; Time Factors | 2013 |
Voltage drives diverse endocannabinoid signals to mediate striatal microcircuit-specific plasticity.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Corpus Striatum; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Green Fluorescent Proteins; In Vitro Techniques; Lidocaine; Male; Membrane Transport Modulators; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Parvalbumins; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RGS Proteins; Signal Transduction; Synapses; TRPV Cation Channels | 2013 |
Pain fiber anesthetic reduces brainstem Fos after tooth extraction.
Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Brain Stem; Capsaicin; Dental Pulp; Electric Stimulation; Electromyography; Lidocaine; Male; Mandibular Nerve; Masticatory Muscles; Molar; Neural Pathways; Neurons, Afferent; Nociceptors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reflex; Sensory System Agents; Time Factors; Tooth Extraction; Trigeminal Caudal Nucleus | 2013 |
Potent and direct presynaptic modulation of glycinergic transmission in rat spinal neurons by atrial natriuretic peptide.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cyclic GMP; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Inhibitory Postsynaptic Potentials; Lidocaine; Neurons; Peptides, Cyclic; Potassium Channel Blockers; Presynaptic Terminals; Rats; Rats, Wistar; Spinal Cord; Thionucleotides | 2013 |
Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Calcium; Cell Line; Foot Injuries; Ganglia, Spinal; Injections; Lidocaine; Male; Mice, Knockout; Nerve Block; Patch-Clamp Techniques; Peripheral Nerves; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium Channel Blockers; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2014 |
Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats.
Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Hyperalgesia; Hypersensitivity, Delayed; Lidocaine; Male; Nerve Block; Nerve Fibers; Neural Conduction; Neurotoxicity Syndromes; Nociceptors; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels | 2014 |
Sidedness of carbamazepine accessibility to voltage-gated sodium channels.
Topics: Carbamazepine; Cell Membrane Permeability; Cells, Cultured; Humans; Lidocaine; NAV1.7 Voltage-Gated Sodium Channel; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels | 2014 |
Emulsified isoflurane enhances thermal transient receptor potential vanilloid-1 channel activation-mediated sensory/nociceptive blockade by QX-314.
Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Emulsions; Fat Emulsions, Intravenous; Ganglia, Spinal; Hot Temperature; Isoflurane; Lidocaine; Motor Neurons; Nerve Block; Nociceptors; Pain Measurement; Phospholipids; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Sensory Receptor Cells; Soybean Oil; Tail; TRPV Cation Channels | 2014 |
The modulation of the permeability and the cellular uptake of liposome by stable anchoring of lipid-conjugated pluronic on liposome.
Topics: Animals; Cell Membrane Permeability; Drug Carriers; Drug Compounding; Drug Stability; Fluorescein; Lidocaine; Liposomes; Mice; Nanoconjugates; NIH 3T3 Cells; Permeability; Poloxamer | 2014 |
The quaternary lidocaine derivative QX-314 produces long-lasting intravenous regional anesthesia in rats.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Animals; Cardiovascular System; Central Nervous System; Lidocaine; Phlebotomy; Rats, Sprague-Dawley; Tail; TRPV Cation Channels; Ultrasonography | 2014 |
Local anesthetic lidocaine inhibits TRPM7 current and TRPM7-mediated zinc toxicity.
Topics: Anesthetics, Local; Cells, Cultured; Cerebral Cortex; HEK293 Cells; Humans; Intracellular Space; Ions; Lidocaine; Membrane Potentials; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Procaine; Protein Serine-Threonine Kinases; TRPM Cation Channels; Zinc | 2015 |
External QX-314 inhibits evoked cranial primary afferent synaptic transmission independent of TRPV1.
Topics: Anesthetics, Local; Animals; Capsaicin; Cranial Nerves; Excitatory Postsynaptic Potentials; Lidocaine; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Reaction Time; TRPV Cation Channels | 2014 |
Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.
Topics: Action Potentials; Animals; Animals, Newborn; Biophysical Phenomena; Conditioning, Psychological; Disease Models, Animal; Epilepsies, Myoclonic; Excitatory Postsynaptic Potentials; Fear; Hippocampus; Hyperthermia, Induced; In Vitro Techniques; Lidocaine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Neural Inhibition; Sodium Channel Blockers | 2015 |
The Pronociceptive Effect of Paradoxical Sleep Deprivation in Rats: Evidence for a Role of Descending Pain Modulation Mechanisms.
Topics: Animals; Bicuculline; Lidocaine; Male; Morphine; Motor Activity; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Rats, Wistar; Sleep Deprivation | 2016 |
Photoswitchable fatty acids enable optical control of TRPV1.
Topics: Animals; Azo Compounds; Bradykinin; Capsaicin; Fatty Acids; Ganglia, Spinal; HEK293 Cells; Humans; In Vitro Techniques; Lidocaine; Lipid Metabolism; Mice; Photochemical Processes; Photochemistry; Serotonin; TRPV Cation Channels | 2015 |
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
Topics: Airway Remodeling; Anesthetics, Local; Animals; Animals, Newborn; Capsaicin; Cytokines; Disease Models, Animal; Freund's Adjuvant; Green Fluorescent Proteins; Interleukin-5; Lidocaine; Mice; Nociceptors; Ovalbumin; Respiratory Hypersensitivity; Time Factors; Vasoactive Intestinal Peptide | 2015 |
Selective Gating of Neuronal Activity by Intrinsic Properties in Distinct Motor Rhythms.
Topics: 4-Aminopyridine; Action Potentials; Anesthetics, Local; Animals; Ataxins; Central Pattern Generators; Excitatory Postsynaptic Potentials; Female; Gonadotropins; Humans; Lidocaine; Locomotion; Male; Nerve Tissue Proteins; Neural Inhibition; Periodicity; Potassium Channel Blockers; Sensory Gating; Swimming; Xenopus | 2015 |
Hitting a nerve to ease asthma.
Topics: Anesthetics, Local; Animals; Asthma; Bronchial Spasm; Inflammation; Lidocaine; Lung; Mice; Nociceptors | 2015 |
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
Topics: Adult; Aged; Anesthetics, Local; Animals; Antineoplastic Agents; Capsaicin; Diabetic Neuropathies; Female; Flagellin; Ganglia, Spinal; Humans; Hyperalgesia; Lidocaine; Male; Mice; Mice, Knockout; Middle Aged; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neuralgia; Neurofilament Proteins; Neurons; Paclitaxel; Peripheral Nerve Injuries; Sensory System Agents; Toll-Like Receptor 5 | 2015 |
Targeting Toll-like receptors to treat chronic pain.
Topics: Anesthetics, Local; Animals; Chronic Pain; Flagellin; Humans; Hyperalgesia; Lidocaine; Mice; Nerve Fibers, Myelinated; Neuralgia; Sensory Receptor Cells; Toll-Like Receptor 5 | 2015 |
Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil.
Topics: Acetanilides; Anesthetics, Local; Animals; Anti-Bacterial Agents; Antimetabolites; Carcinosarcoma; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Eating; Fluorouracil; Hyperalgesia; Leukocytes; Lidocaine; Male; Microbial Viability; Pain; Pain Management; Polymyxin B; Purines; Rats; Rats, Wistar; Stomatitis; Trigeminal Ganglion; TRPV Cation Channels | 2016 |
Quaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity.
Topics: Anesthetics, Local; Calcium; Calcium Channels; Cell Survival; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Lidocaine; NAV1.7 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Sodium Channel Blockers; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2016 |
Effects of a quaternary lidocaine derivative, QX-314, on the respiratory activity in brainstem-spinal cord preparation from newborn rats.
Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Brain Stem; In Vitro Techniques; Lidocaine; Neurons; Periodicity; Respiratory Center; Spinal Cord | 2016 |
Auditory Golgi cells are interconnected predominantly by electrical synapses.
Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Cesium; Chlorides; Cochlear Nucleus; Connexins; Electrical Synapses; Gap Junction delta-2 Protein; Green Fluorescent Proteins; Humans; Interleukin-2 Receptor alpha Subunit; Lidocaine; Mice; Mice, Transgenic; Nerve Net; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Potassium Channel Blockers; Reaction Time; Receptors, Metabotropic Glutamate | 2016 |
Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1-expressing Primary Afferents in Mice.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bone Neoplasms; Cyclic AMP Response Element-Binding Protein; Ganglia, Spinal; Lidocaine; Male; Mice; Mice, Inbred C3H; Movement; Pain; Pain Measurement; Postural Balance; Psychomotor Performance; TRPV Cation Channels; Weight-Bearing | 2016 |
Effects of Liposomes Charge on Extending Sciatic Nerve Blockade of N-ethyl Bromide of Lidocaine in Rats.
Topics: Anesthetics, Local; Animals; Immunohistochemistry; Lidocaine; Liposomes; Molecular Structure; Nerve Block; Proton Magnetic Resonance Spectroscopy; Rats; Sciatic Nerve; Time Factors | 2016 |
Cellular permeation of large molecules mediated by TRPM8 channels.
Topics: Anesthetics, Local; Animals; Cell Line; Ganglia, Spinal; Humans; Lidocaine; Nociceptors; Pain; Rats; Sensory Receptor Cells; Thermosensing; Transient Receptor Potential Channels; TRPM Cation Channels | 2017 |
Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants.
Topics: Acetamides; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Benzhydryl Compounds; Binding Sites; Carbamazepine; Cocaine; Humans; Lacosamide; Lamotrigine; Lidocaine; Molecular Docking Simulation; NAV1.4 Voltage-Gated Sodium Channel; Phenols; Phenytoin; Piperazines; Protein Binding; Pyrimidines; Quinidine; Sodium Channel Blockers; Triazines | 2017 |
The quaternary lidocaine derivative QX-314 in combination with bupivacaine for long-lasting nerve block: Efficacy, toxicity, and the optimal formulation in rats.
Topics: Anesthetics, Local; Animals; Bupivacaine; Lidocaine; Male; Models, Theoretical; Nerve Block; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Treatment Outcome | 2017 |
QX-OH, a QX-314 derivative agent, produces long-acting local anesthesia in rats.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Lidocaine; Male; Muscle, Skeletal; Nerve Block; Rats, Sprague-Dawley; Reflex; Sciatic Nerve | 2017 |
Addition of dexmedetomidine to QX-314 enhances the onset and duration of sciatic nerve block in rats.
Topics: Action Potentials; Animals; Dexmedetomidine; Hot Temperature; Lidocaine; Male; Nerve Block; Nociception; Ranidae; Rats, Sprague-Dawley; Sciatic Nerve; Time Factors | 2018 |
Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.
Topics: Anesthetics, Local; Animals; Bacterial Toxins; Gene Knockdown Techniques; Lidocaine; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred C57BL; Neurons; Pain; Staphylococcal Infections; TRPV Cation Channels | 2018 |
Nano-engineered microcapsules boost the treatment of persistent pain.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Cells, Cultured; Chronic Pain; Drug Delivery Systems; Hippocampus; Lidocaine; Male; Nanocapsules; Rats; Rats, Sprague-Dawley; Rats, Wistar; Treatment Outcome | 2018 |
QX-314 inhibits acid-induced activation of esophageal nociceptive C fiber neurons.
Topics: Acrylamides; Action Potentials; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Esophagus; Guinea Pigs; Hydrochloric Acid; Lidocaine; Nerve Fibers, Unmyelinated; Nociception; Patch-Clamp Techniques; TRPV Cation Channels | 2019 |
Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation.
Topics: Animals; Bupivacaine; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Signaling; Disease Models, Animal; Ganglia, Spinal; Humans; Lidocaine; Mice; Neurogenic Inflammation; Nociceptors; Pain; Sodium Channel Blockers; Sodium Channels | 2019 |
Co-Application of Eugenol and QX-314 Elicits the Prolonged Blockade of Voltage-Gated Sodium Channels in Nociceptive Trigeminal Ganglion Neurons.
Topics: Animals; Drug Interactions; Eugenol; Lidocaine; Male; Neurons; Nociception; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels | 2020 |
Atractylodin Produces Antinociceptive Effect through a Long-Lasting TRPA1 Channel Activation.
Topics: Analgesics; Animals; Calcium; Calcium Channels; Furans; Ganglia, Spinal; HEK293 Cells; Humans; Isothiocyanates; Lidocaine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nociception; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPC Cation Channels | 2021 |
Low potency inhibition of Na
Topics: Anesthetics, Local; HEK293 Cells; Humans; Lidocaine; Sodium; Sodium Channel Blockers | 2022 |