lidocaine has been researched along with prazosin in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (18.92) | 18.7374 |
| 1990's | 3 (8.11) | 18.2507 |
| 2000's | 17 (45.95) | 29.6817 |
| 2010's | 10 (27.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Wood, M | 1 |
| Schwartz, PJ; Vanoli, E | 1 |
| Horiguchi, Y; Kogi, K; Tani, T | 1 |
| Russell, RD; Stripling, JS | 1 |
| Schwartz, PJ; Vanoli, E; Zaza, A; Zuanetti, G | 1 |
| Insel, PA; Maisel, AS; Motulsky, HJ; Snavely, MD | 1 |
| Chan, JY; Chan, SH; Shih, CD | 1 |
| Altenburg, SP; Farah, MB | 1 |
| Berlioz, F; Carbon, C; Chariot, J; Farinotti, R; Julien, S; Rozé, C; Tsocas, A | 1 |
| Fatani, AJ; Furman, BL; Harvey, AL; Rowan, EG | 1 |
| Fukuda, I; Kamei, M; Karasawa, F; Nakai, T; Satoh, T; Uchihashi, Y | 1 |
| Chen, DY; Chen, HC; Liang, KC | 1 |
| Corrêa, FM; Peres-Polon, VL; Tavares, RF | 1 |
| Belardinelli, L; Dhalla, AK; Robertson, C; Wang, WQ | 1 |
| Higuchi, H; Kohjitani, A; Maeda, S; Miyawaki, T; Shimada, M; Yoshitomi, T | 1 |
| Ansah, OB; Linderoth, B; Meyerson, BA; Pertovaara, A; Song, Z | 1 |
| Kokare, DM; Kumar, S; Shelkar, GP; Singru, PS; Subhedar, NK | 1 |
2 review(s) available for lidocaine and prazosin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Plasma drug binding: implications for anesthesiologists.
Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Cardiac Surgical Procedures; Chlorpromazine; Dipyridamole; Disopyramide; Etidocaine; Female; Fentanyl; Half-Life; Humans; Imipramine; Kidney Diseases; Lidocaine; Liver; Mathematics; Meperidine; Methadone; Myocardial Infarction; Orosomucoid; Prazosin; Pregnancy; Propranolol; Protein Binding; Quinidine; Serum Albumin; Sex Factors | 1986 |
35 other study(ies) available for lidocaine and prazosin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Identification and prediction of promiscuous aggregating inhibitors among known drugs.
Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship | 2003 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
An experimental approach to the choice of antiarrhythmic therapy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil | 1986 |
Inhibitory effects of formaldehyde inhalation on the cardiovascular and respiratory systems in unanesthetized rabbits.
Topics: Animals; Atropine; Formaldehyde; Guanethidine; Heart Rate; Hemodynamics; Lidocaine; Male; Parasympatholytics; Phenoxybenzamine; Prazosin; Rabbits; Respiration; Sympatholytics | 1986 |
Monoaminergic and local anesthetic components of cocaine's effects on kindled seizure expression.
Topics: Amphetamine; Anesthetics, Local; Animals; Biogenic Amines; Cocaine; Drug Interactions; Haloperidol; Kindling, Neurologic; Lidocaine; Male; Metergoline; Prazosin; Propranolol; Rats; Seizures; Yohimbine | 1985 |
The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Disease Models, Animal; Electrocardiography; Hemodynamics; Lidocaine; Mexiletine; Prazosin; Propranolol; Stellate Ganglion | 1985 |
Quinidine is a competitive antagonist at alpha 1- and alpha 2-adrenergic receptors.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Blood Platelets; Humans; In Vitro Techniques; Kidney; Lidocaine; Myocardium; Prazosin; Quinidine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1984 |
Participation of hypothalamic paraventricular nucleus in locus ceruleus-induced baroreflex suppression in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Baroreflex; Denervation; Immune Sera; Lidocaine; Locus Coeruleus; Male; Microinjections; Neuropeptide Y; Paraventricular Hypothalamic Nucleus; Prazosin; Rats; Rats, Sprague-Dawley; Yohimbine | 1995 |
Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonidine; Drug Interactions; Lidocaine; Male; Mice; Phentolamine; Prazosin; Receptors, Adrenergic, alpha-2; Seizures; Time Factors; Yohimbine | 1999 |
Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo.
Topics: Adrenergic Antagonists; Animals; ATP-Binding Cassette Transporters; Bacterial Proteins; Cephalexin; Cephalosporins; Hexamethonium; Intestinal Absorption; Jejunum; Lidocaine; Male; Membrane Transport Proteins; Microvilli; Nifedipine; Prazosin; Rats; Rats, Wistar; Yohimbine | 1999 |
The effects of lignocaine on actions of the venom from the yellow scorpion "Leiurus quinquestriatus" in vivo and in vitro.
Topics: Animals; Atropine; Chickens; Drug Interactions; Guanethidine; Guinea Pigs; Hemodynamics; Hexamethonium; In Vitro Techniques; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Prazosin; Rabbits; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Sodium Channels; Tubocurarine | 2000 |
Effects of alpha adrenoreceptor antagonists, prazosin and. yohimbine, on intrathecal lidocaine-induced antinociception in mice.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Injections, Spinal; Lidocaine; Male; Mice; Pain Measurement; Prazosin; Reaction Time; Reflex; Yohimbine | 2000 |
Posttraining infusion of norepinephrine and corticotropin releasing factor into the bed nucleus of the stria terminalis enhanced retention in an inhibitory avoidance task.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Avoidance Learning; Corticotropin-Releasing Hormone; Electroshock; Idazoxan; Lidocaine; Locomotion; Male; Memory; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Wistar; Reflex, Startle; Septal Nuclei | 2001 |
Mechanisms involved in the water intake-related pressor response in the rat.
Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Brazil; Diazepam; Dose-Response Relationship, Drug; Drinking; Heart Rate; Idazoxan; Lidocaine; Losartan; Male; Mecamylamine; Models, Animal; Muscle Relaxants, Central; Prazosin; Quinine; Rats; Rats, Wistar; Sodium Chloride; Tropanes; Water | 2002 |
Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits.
Topics: Acetanilides; Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Female; Heart Rate; Lidocaine; Methoxamine; Phenylephrine; Piperazines; Potassium Channel Blockers; Prazosin; Quaternary Ammonium Compounds; Rabbits; Ranolazine; Torsades de Pointes | 2008 |
Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor.
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Clonidine; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Lidocaine; Male; Oxymetazoline; Prazosin; Receptors, Adrenergic, alpha-2; Yohimbine | 2008 |
Exploration of supraspinal mechanisms in effects of spinal cord stimulation: role of the locus coeruleus.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Local; Animals; Disease Models, Animal; Electric Stimulation; Hyperalgesia; Imidazoles; Lidocaine; Locus Coeruleus; Male; Neural Pathways; Neurons; Pain Threshold; Physical Stimulation; Prazosin; Rats; Rats, Wistar; Sciatica; Spinal Cord | 2013 |
Noradrenergic inputs from locus coeruleus to posterior ventral tegmental area are essential to support ethanol reinforcement.
Topics: Acetaldehyde Dehydrogenase Inhibitors; Adrenergic Agents; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic Neurons; Anesthetics, Local; Animals; Behavior, Animal; Benzazepines; Benzylamines; Central Nervous System Depressants; Conditioning, Operant; Disulfiram; Dopamine Antagonists; Ethanol; GABA-A Receptor Agonists; Lidocaine; Locus Coeruleus; Male; Muscimol; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Dopamine D1; Reinforcement, Psychology; Reward; Self Administration; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2017 |