lidocaine has been researched along with pilsicainide in 200 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (7.50) | 18.7374 |
| 1990's | 37 (18.50) | 18.2507 |
| 2000's | 104 (52.00) | 29.6817 |
| 2010's | 37 (18.50) | 24.3611 |
| 2020's | 7 (3.50) | 2.80 |
| Authors | Studies |
|---|---|
| Aisaka, K; Hayashimatsu, M; Miyano, S; Morita, M; Noguchi, T; Satoh, F; Shima, K; Sumoto, K | 1 |
| Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L | 1 |
| Sen, S; Sinha, N | 1 |
| Arita, M; Kiyosue, T; Sato, T; Wu, B | 1 |
| Kato, R; Koide, M; Miyahara, T; Sotobata, I; Toyama, J; Ukai, M; Yasui, S; Yokota, M | 1 |
| Hattori, Y; Inomata, N | 1 |
| Handa, S; Ogawa, S; Okada, Y; Sadanaga, T | 1 |
| Ikeda, N; Kamiya, K | 1 |
| Hashimoto, H; Nakashima, M; Satoh, N | 1 |
| Akaike, N; Inomata, N; Ishihara, T | 3 |
| Goto, T; Hayashi, H; Isikawa, S; Ito, A; Kato, R; Sotobata, I; Suzuki, M; Terazawa, T | 1 |
| Hara, H; Hashimoto, N; Ishida, Y; Nakamura, S; Ohta, H; Sasaki, T; Satoh, S; Takabatake, T; Ushiogi, Y; Yamamoto, Y | 1 |
| Hashimoto, K; Ishii, M; Komori, S; Mitsuhashi, H | 1 |
| Inomata, N; Ishihara, T | 1 |
| Aisaka, K; Hattori, Y; Hidaka, T; Ishihara, T; Satoh, F | 1 |
| Endoh, S; Hangai, K; Keitoku, M; Kinoshita, H; Morita, M; Ohtsuka, K; Satoh, S; Sekiguchi, N; Takishima, T; Watanabe, J | 1 |
| Hanaki, Y; Hieda, N; Ogawa, T; Ozawa, T; Sugiyama, S; Taki, K | 1 |
| Hattori, Y; Ishihara, T; Kodama, I; Kusunoki, T; Toyama, J; Yamada, K | 1 |
| Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K | 1 |
| Hatta, M; Hattori, Y; Hirose, N; Hirotsu, I; Ishihara, T; Kihara, T; Satoh, F | 1 |
| Aisaka, K; Hattori, Y; Hidaka, T; Inomata, N; Ishihara, T; Satoh, F | 1 |
| Aisaka, K; Hamasaki, S; Hidaka, T; Inomata, N; Ishihara, T; Morita, M | 1 |
| Aisaka, K; Hamasaki, S; Hidaka, T; Ishihara, T; Morita, M; Toyama, J; Yamada, K | 1 |
| Akaike, N; Yatani, A | 1 |
| Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Sakai, R; Shirayama, T; Yamahara, Y | 1 |
| Ogawa, S; Sadanaga, T | 1 |
| Ajiki, K; Inoue, H; Murakawa, Y; Nakajima, T; Ohkawa, S; Oikawa, N; Sugimoto, T; Usui, M; Yamashita, T | 1 |
| Higuchi, M; Itomine, T; Matsuzaki, T; Nakasone, J; Noguchi, K; Ojiri, Y; Sakanashi, M; Shiroma, N | 1 |
| Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Omori, I; Sakai, R; Shirayama, T; Yamahara, Y | 1 |
| Liu, JX; Ohtsuka, Y; Sakai, Y; Takeo, S; Tanonaka, K | 1 |
| Akaishi, M; Handa, S; Iwanaga, S; Ogawa, S; Okada, Y; Sadanaga, T; Tsutsumi, N; Yoshikawa, T | 1 |
| Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Omori, I; Sakai, R; Yamahara, Y | 1 |
| Akaike, N; Inomata, N; Ishihara, T; Ohno, T | 1 |
| Hatakeyama, N; Inoko, M; Kihara, Y; Momose, Y; Sasayama, S | 1 |
| Nakata, Y; Nakazato, K; Nakazato, Y; Ogura, S; Sumiyoshi, M; Tokano, T; Yamagami, S; Yamaguchi, H; Yasuda, M | 1 |
| Atarashi, H; Hayakawa, H; Hiejima, K; Inoue, H | 1 |
| Fujiki, A; Inoue, H; Tani, M; Yoshida, S | 1 |
| Baba, S; Funakoshi, M; Ishide, N; Iwabuchi, K; Katoh, H; Keitoku, M; Miura, M; Satoh, S; Shinozaki, T; Shirato, K; Suzuki, S; Takeuchi, M; Watanabe, J | 1 |
| Fujiki, A; Hayashi, H; Inoue, H; Tani, M; Usui, M | 1 |
| Atarashi, H; Hayakawa, H; Ino, T; Kuruma, A; Onodera, T; Saitoh, H | 1 |
| Annoura, M; Arakawa, K; Ideishi, M; Kumagai, K; Matsuo, K | 1 |
| Arita, M; Sato, T; Shigematsu, S | 1 |
| Gomi, A; Kohno, K; Nagano, N; Nakatani, H; Shimabukuro, T; Suda, Y; Takeuchi, Y | 1 |
| Fukui, E; Hayami, N; Inoue, M; Murakawa, Y; Omata, M; Sezaki, K; Yamashita, T | 1 |
| Ito, H; Nakamura, W; Segawa, K; Tanaka, S; Yoshimoto, N | 1 |
| Iwasa, A; Matsunaga, T; Okumura, K; Tabuchi, T; Tayama, S; Tsuchiya, T; Tsunoda, R; Yasue, H | 1 |
| Kanki, H; Mitamura, H; Ogawa, S; Sato, T; Shinagawa, K; Sueyoshi, K; Takatsuki, S | 1 |
| Asano, Y; Fukunami, M; Hoki, N; Hori, M; Kumagai, K; Ogita, H; Sanada, S; Shimonagata, T; Yamada, T | 1 |
| Hiraoka, M; Inoue, H; Kasanuki, H; Kato, T; Kodama, I; Mitamura, H; Ogawa, S; Sugimoto, T | 1 |
| Fujiki, A; Hayashi, H; Inoue, H; Mizumaki, K; Nagasawa, H; Usui, M | 1 |
| Matsuo, S; Ozeki, S; Utsunomiya, T; Yano, K | 1 |
| Ashihara, T; Nakazawa, K; Namba, T; Ohe, T | 1 |
| Kanki, H; Mitamura, H; Ogawa, S; Sato, T; Shinagawa, K; Takatsuki, S; Takeshita, A | 1 |
| Arita, M; Kaku, T; Kitabatake, A; Makita, N; Ono, K | 1 |
| Hashiguchi, M; Kasanuki, H; Rikihisa, T; Shiga, T; Urae, A | 1 |
| Akkaya, V; Atilgan, D; Demirel, S; Güven, O; Korkut, F; Kudat, H; Ozcan, M; Sözen, AB; Tükek, T | 1 |
| Izumi, T; Kitano, Y; Moriguchi, M; Niwano, S | 1 |
| Hayashi, Y; Hidaka, T; Inomata, N; Inoue, T; Komoriya, K | 1 |
| Aonuma, K; Azegami, K; Igawa, M; Nishizaki, M; Okishige, K; Yamawaki, N | 1 |
| Abe, T; Fuse, K; Murooka, H; Saigawa, T; Susa, R; Toeda, T; Yamaguchi, Y | 1 |
| Aye, NN; Hashimoto, K; Miyamoto, S; Teramatsu, T; Zhu, B | 1 |
| Abe, H; Kohshi, K; Nagatomo, T; Nakashima, Y; Numata, T | 2 |
| Kawano, Y; Mineda, Y; Nakata, Y; Nakazato, K; Nakazato, Y; Sekita, G; Sumiyoshi, M; Tokano, T; Yamashita, H; Yasuda, M | 1 |
| Abe, H; Hiraki, T; Ikeda, H; Imaizumi, T; Kumagai, K; Nakashima, H; Nakashima, Y; Oginosawa, Y; Saku, K | 1 |
| Emori, T; Hisamatsu, K; Kusano, KF; Matsubara, H; Morita, H; Nagase, S; Nakamura, K; Ohe, T; Takenaka, S | 1 |
| Azegami, K; Hiejima, K; Hirao, K; Horikawa, T; Kawabata, M; Motokawa, K; Suzuki, F; Suzuki, K | 1 |
| Fujii, Z; Fujimoto, K; Kawata, Y; Matsumoto, M; Matsuzaki, M; Minami, M; Nawata, C; Sakumura, T | 1 |
| Conway, DS; Lip, GY | 1 |
| Fujito, H; Mori, M; Saita, T | 1 |
| Kimura, M; Komatsu, T; Nakamura, S; Okumura, K; Owada, S; Tomita, H; Yomogida, K | 1 |
| Nattel, S | 1 |
| Hara, M; Kanki, H; Kurita, Y; Mitamura, H; Miyoshi, S; Ogawa, S; Sato, T; Shinagawa, K; Takeshita, A | 1 |
| Nakata, Y; Nakazato, Y | 1 |
| Aiba, T; Kamakura, S; Kurita, T; Shimizu, W | 1 |
| Aizawa, Y; Chinushi, M; Chinushi, Y; Toida, T | 1 |
| Abe, T; Fu, LT; Iinuma, H; Kirigaya, H; Nakada, M; Sagara, K; Sahara, M; Watanabe, H; Yamashita, T | 1 |
| Furuta, I; Kitahashi, T | 1 |
| Doi, A; Takagi, M; Takeuchi, K; Yoshikawa, J | 1 |
| Fujiki, A; Inoue, H; Mizumaki, K; Nishida, K; Sakabe, M; Sugao, M; Tsuneda, T | 1 |
| Imai, H; Matoba, Y; Nakagawa, M; Shiraishi, H; Shirayama, T; Yoshida, S | 1 |
| Hara, H; Ikeda-Murakami, K; Inuo, K; Izumi, T; Kojima, J; Niwano, S; Saito, J; Yoshida, T | 2 |
| Ashihara, T; Hirai, H; Ikeda, T; Kawase, A; Kubota, T; Nakazawa, K; Namba, T; Sugi, K | 1 |
| Katoh, T; Ono, T; Sutovsky, I; Takano, T; Takayama, H | 1 |
| Emori, T; Fukushima-Kusano, K; Kakishita, M; Kobayashi, M; Matsubara, H; Morita, H; Nagase, S; Nakamura, K; Ohe, T; Takenaka-Morita, S | 1 |
| Ikeda, K; Inuo, K; Izumi, T; Kojima, J; Moriguchi, M; Niwano, S; Saito, J | 1 |
| Aonuma, K; Doi, H; Hosokawa, N; Kato, K; Kubota, S; Nakamura, H; Nakao, M; Nitta, J; Nogami, A; Sagai, H; Sugiyasu, A; Tamaki, T; Yamauchi, Y; Yokoyama, K; Yumoto, K | 1 |
| Kubota, I; Nagai, S; Takeishi, Y | 1 |
| Kanmatsuse, K; Kasamaki, Y; Kofune, T; Masaki, R; Ohkubo, K; Okumura, Y; Oshikawa, N; Ozawa, Y; Saito, S; Watanabe, I; Yamada, T | 1 |
| Furuhashi, M; Hoshikawa, K; Sakai, E; Satoh, S; Shimamoto, K; Tsuchihashi, K; Uno, K | 1 |
| Hirano, Y; Hiraoka, M; Kawano, S; Orikabe, M; Wu, LM | 1 |
| Ebina, T; Ishikawa, T; Kimura, K; Kobayashi, T; Matsumoto, K; Matsushita, K; Mochida, Y; Nakagawa, T; Nakazawa, I; Ohkusu, Y; Sumita, S; Uchino, K; Umemura, S; Yamakawa, Y | 2 |
| Banba, K; Emori, T; Hina, K; Kita, T; Kusano, KF; Matsubara, H; Morita, H; Morita, ST; Nagase, S; Nakamura, K; Nishii, N; Ohe, T; Tani, Y; Watanabe, A | 1 |
| Ashikaga, K; Higuma, T; Iwasa, A; Kimura, M; Kobayashi, T; Motomura, S; Okumura, K; Owada, S; Sasaki, S | 1 |
| Kanmatsuse, K; Kofune, T; Masaki, R; Okubo, K; Okumura, Y; Oshikawa, N; Ozawa, Y; Saito, S; Sugimura, H; Takagi, Y; Wakita, R; Watanabe, I; Yamada, T | 1 |
| Arai, M; Kishi, R; Miyake, F; Nakazawa, K; Osada, K; Ryu, S; Takagi, A | 1 |
| Ando, A; Hirai, M; Inden, Y; Isobe, S; Murohara, T; Nonokawa, M; Okada, M; Suzuki, A; Takada, Y; Tomita, Y | 1 |
| Dohi, S; Iida, H; Oda, A; Osawa, Y; Tanahashi, S | 1 |
| Esato, M; Inoue, N; Kakugawa, H; Kametani, R; Kanemoto, M; Matsuzaki, M; Sawa, A; Shimizu, A; Ueyama, T; Yamagata, T; Yoshiga, Y | 1 |
| Imaki, R; Inuo, K; Izumi, T; Morohoshi, Y; Nakayama, S; Niwano, S; Yuge, M | 1 |
| Fujimura, A; Sakamoto, K; Shiga, T; Tsuruoka, S; Wakaumi, M | 1 |
| Kumagai, K; Nakashima, H; Noguchi, H; Ogawa, M; Saku, K; Tojo, H; Yasuda, T; Zhang, B | 1 |
| Funada, A; Horita, Y; Kaku, B; Kanaya, H; Kitajima, S; Matsumura, M; Satoh, T; Uno, Y; Yamazaki, T | 1 |
| Hiasa, G; Nishimura, K; Okayama, H; Sumimoto, T | 1 |
| Hashimoto, K; Honsho, S; Nakamura, Y; Sugiyama, A; Takahara, A | 1 |
| Aizawa, T; Fu, LT; Goda, A; Itoh, H; Kato, T; Kirigaya, H; Koike, A; Sagara, K; Yamashita, T | 1 |
| Fukumoto, K; Kamakura, S; Kusumoto, M; Matsumoto, K; Tanemura, M; Tsuchishita, Y; Ueno, K | 1 |
| Higa, N; Kosugi, T; Shimabukuro, M; Sunagawa, M; Takasu, N; Yamakawa, M | 1 |
| Azegami, K; Hirao, K; Isobe, M; Okishige, K; Otomo, K; Yamamoto, N | 1 |
| Kumagai, K; Miura, S; Nakashima, H; Noguchi, H; Ogawa, M; Saku, K; Tojo, H; Yasuda, T; Zhang, B | 1 |
| Aizawa, Y; Chinushi, M; Hirono, T; Komura, S; Sugiura, H | 1 |
| Echizen, H; Kishi, R; Kobayashi, S; Masuhara, K; Matsumoto, N; Mihara, K; Miyake, F; Nakazawa, K; Ogawa, R; Takagi, A; Takahashi, H | 1 |
| Mato, T; Moriwaki, R; Nakata, K; Takenouchi, S; Tsutsumi, H; Yamaguchi, A | 1 |
| Fujimura, A; Ioka, T; Ookami, H; Sakamoto, K; Tsuruoka, S; Wakaumi, M | 1 |
| Aihara, N; Kamakura, S; Kurita, T; Nagai, T; Noda, T; Satomi, K; Shimizu, W; Suyama, K | 1 |
| Aiba, T; Hidaka, I; Inagaki, M; Kamiya, A; Noda, T; Shimizu, W; Sugimachi, M; Sunagawa, K; Uemura, K; Zheng, C | 1 |
| Atarashi, H; Fukunami, M; Inoue, H; Kumagai, K; Okishige, K | 1 |
| Horiuchi, D; Komatsu, T; Nakamura, M; Okumura, K; Sato, Y; Tachibana, H | 1 |
| Abe, A; Ikeda, T; Ishiguro, H; Mera, H; Nakamura, K; Yoshino, H; Yotsukura, M; Yusu, S | 1 |
| Arakaki, T; Isomoto, S; Kawakami, A; Ono, K; Yamashita, S; Yano, K | 1 |
| Araki, S; Ogawa, H; Sadanaga, T; Tanaka, Y | 1 |
| Kumagai, K; Matsumoto, N; Nakashima, H; Noguchi, H; Ogawa, M; Saku, K; Tojo, H; Yasuda, T | 1 |
| Katoh, T; Kobayashi, Y; Morita, N; Ohara, T; Takano, T; Takayama, H; Yodogawa, K | 1 |
| Baltes, E; Strolin-Benedetti, M; Whomsley, R | 1 |
| Esato, M; Kametani, R; Kanemoto, M; Matsuzaki, M; Ohmura, M; Sawa, A; Shimizu, A; Sugi, N; Suzuki, S; Ueyama, T; Yamagata, T; Yoshiga, Y | 1 |
| Aizawa, Y; Chinushi, M; Furushima, H; Izumi, D; Watanabe, H | 1 |
| Morita, H; Morita, ST; Wu, J; Zipes, DP | 2 |
| Deschênes, I; Laurita, KR | 1 |
| Fujita, S; Ishikawa, Y; Kishi, R; Matsuda, H; Miyake, F; Nakazawa, K; Osada, K; Ryu, S; Sakurai, T; Takagi, A | 1 |
| Saikawa, T; Shinohara, T; Takahashi, N; Yoshimatsu, H | 1 |
| Aizawa, Y; Chinushi, M; Furushima, H; Izumi, D; Komura, S; Tanabe, Y; Washizuka, T | 1 |
| Endo, N; Hirosaka, A; Miura, E; Niitsuma, T; Owada, K; Sekiguchi, Y; Takeda, H; Tamagawa, K; Tsuburaya, R; Yoshisato, T | 1 |
| Banba, K; Kusano, KF; Miura, D; Morita, H; Nagase, S; Nakamura, K; Nishii, N; Ohe, T; Tada, T; Watanabe, A | 1 |
| Hamazaki, M; Hirose, M; Ohkubo, Y; Sekido, T; Takano, M; Yamada, M | 1 |
| Esato, M; Matsuzaki, M; Sawa, A; Shimizu, A; Sugi, N; Suzuki, S; Ueyama, T; Yoshiga, Y | 1 |
| Furukawa, Y; Hiromoto, K; Kanemori, T; Masuyama, T; Mine, T; Ohyanagi, M; Oka, K; Shimizu, H | 1 |
| Furukawa, T; Hachiya, H; Higuchi, K; Hirao, K; Isobe, M; Kawabata, M; Okada, H; Sasaki, T | 1 |
| Madias, JE | 1 |
| Banba, K; Hiramatsu, S; Kusano, KF; Morita, H; Nagase, S; Nakamura, K; Nishii, N; Ohe, T; Sakuragi, S; Watanabe, A | 1 |
| Aoyama, H; Enomoto, M; Hirayama, A; Imai, S; Kushiro, T; Saito, F; Takase, H; Yagi, H; Yamaji, S; Yokoyama, K | 1 |
| Hiramatsu, S; Karshima, E; Maruyama, T; Odashiro, K | 1 |
| Hikiji, W; Ikeda, N; Ishida, T; Kudo, K; Nishida, N; Tsuji, A; Usumoto, Y | 1 |
| Ashino, S; Hirayama, A; Kofune, M; Kofune, T; Nakai, T; Ohkubo, K; Okumura, Y; Watanabe, I | 1 |
| Komatsu, T; Kunigida, F; Nakamura, M; Ohshima, K; Orii, M; Ozawa, M; Sato, Y; Tachibana, H | 1 |
| Mori, K; Nagata, M; Oe, K | 1 |
| Horiuchi, D; Iwasa, A; Kimura, M; Okumura, K; Owada, S; Sasaki, K; Sasaki, S | 1 |
| Harada, M; Honjo, H; Ishiguro, YS; Kamiya, K; Kodama, I; Morishima, M; Nakagawa, H; Okuno, Y; Opthof, T; Sakuma, I; Suzuki, T; Takanari, H; Yamazaki, M | 1 |
| Dosdall, DJ | 1 |
| Fujimoto, N; Kasai, A; Kawasaki, A; Omichi, C | 1 |
| Hong, JH; Jang, IJ; Kim, BH; Kim, JR; Kim, JW; Kim, KP; Lim, KS; Shin, SG; Tanaka, T; Yu, KS | 1 |
| Fujiki, A; Fukaya, H; Hatakeyama, Y; Izumi, T; Kiryu, M; Kurokawa, S; Niwano, H; Niwano, S; Sasaki, T | 1 |
| Aizawa, Y; Chinushi, M; Furushima, H; Izumi, D; Tagawa, M | 1 |
| Iwasaki, H; Nagai, T; Nakamura, Y; Satoh, Y; Shinkai, N; Sugiyama, A; Takahara, A | 1 |
| Doi, A; Maeda, K; Nakagawa, E; Shimeno, K; Takagi, M; Tatsumi, H; Yoshiyama, M | 1 |
| Enjoji, Y; Funatsu, A; Kobayashi, T; Mizobuchi, M; Muranishi, H; Nakamura, S; Utsunomiya, M | 1 |
| Doi, A; Maeda, K; Shimeno, K; Takagi, M; Tatsumi, H; Yoshiyama, M | 1 |
| Echizen, H; Kishi, R; Kobayashi, S; Masuhara, K; Matsumoto, N; Miyake, F; Nakazawa, K; Ogawa, R; Sakaue, I; Takagi, A; Takahashi, H | 1 |
| Plosker, GL | 1 |
| Doi, M; Matsuzaki, M; Ohmiya, T; Ohno, M; Shimizu, A; Sugi, N; Ueyama, T; Yoshida, M; Yoshiga, Y | 1 |
| Adachi, T; Hisada, T; Ikewaki, K; Miyagawa, T; Ogata, K; Ohsuzu, F; Sakai, M; Sakurai, Y; Tsujimoto, T; Yakushiji, T | 1 |
| Bruno, C; Conte Camerino, D; Costanza, T; Desaphy, JF; Dipalma, A; Franchini, C; George, A; Lentini, G | 1 |
| Imai, T; Kajimoto, K; Kasanuki, H; Minami, Y | 1 |
| Doi, S; Hata, A; Hinokiyama, H; Ibata, T; Iijima, H; Komuro, R; Mito, S; Nakashita, C; Sato, M; Shiki, S | 1 |
| Ashino, S; Hirayama, A; Kasamaki, Y; Kofune, M; Kunimoto, S; Nagashima, K; Nakai, T; Ohkubo, K; Okumura, Y; Watanabe, I | 1 |
| Fukuda, K; Kondo, M; Kumagai, K; Miura, M; Nakano, M; Shimokawa, H; Shirato, K; Wakayama, Y; Watanabe, J; Yagi, T | 1 |
| Matsuzaki, M; Murata, K; Nose, Y; Tanaka, T; Ueyama, T; Wada, Y | 1 |
| Kaneko, Y; Kato, T; Kurabayashi, M; Nakajima, T | 1 |
| Fujiwara, R; Fukuzawa, K; Hirata, K; Imamura, K; Itoh, M; Kanda, G; Kumagai, H; Suzuki, A; Takami, K; Takami, M; Takei, A; Tanaka, S; Yoshida, A | 1 |
| Hagiwara, M; Namekata, I; Takahara, A; Takeda, K; Tanaka, H; Tsuneoka, Y | 1 |
| Hirayama, A; Kofune, M; Mano, H; Nagashima, K; Ohkubo, K; Okumura, Y; Sonoda, K; Watanabe, I | 1 |
| Adachi-Akahane, S; Ikeda, T; Kitahara, K; Nakamura, Y; Sugiyama, A; Takahara, A; Tanaka, H; Tsuneoka, Y; Yamazaki, H; Yamazaki, J | 1 |
| Hagiwara, M; Nozaki, S; Sugiyama, A; Suzuki, S; Takahara, A | 1 |
| Fukami, N; Nakamura, K | 1 |
| Du, H; Li, J; Lin, Y; Liu, W; Qiu, Q; Suo, W; Wei, Y; Wu, W; Yang, K; Zhang, Y; Zhao, G; Zheng, Y; Zhou, Z | 1 |
| Hirao, K; Obayashi, T; Yagishita, A; Yamauchi, Y | 1 |
| Hashiguchi, M; Mochizuki, M; Nakamura, K; Shiga, T; Shimizu, M; Tamura, HO | 1 |
| Aiba, T; Ishibashi, K; Kamakura, S; Kamakura, T; Kimura, T; Kusano, K; Makiyama, T; Miyamoto, K; Nakajima, I; Noda, T; Ogawa, H; Okamura, H; Shimizu, W; Takaki, H; Wada, M; Yasuda, S | 1 |
| Aonuma, K; Sekiguchi, Y; Tada, H; Yamasaki, H | 1 |
| Ai, T; Horie, M; Itoh, H; Makiyama, T; Shimizu, A; Turker, I; Ueyama, T; Vatta, M | 1 |
| Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Nakamura, Y; Sugiyama, A; Wada, T; Yamazaki, H | 1 |
| Doi, A; Hayashi, Y; Kakihara, J; Takagi, M; Tatsumi, H; Yoshiyama, M | 1 |
| Bahrudin, U; Hisatome, I; Inoue, M; Itoh, T; Kato, M; Kawata, Y; Kita, A; Li, P; Morimoto, Y; Murakami, T; Ninomiya, H; Nishio, K; Obara, Y; Saeki, Y; Sakane, I; Sugiyama, R; Tanaka, K; Tsujitani, S; Unno, M; Yamaguchi, H | 1 |
| Ito, H; Kawada, S; Miyamoto, M; Morimoto, Y; Morita, H; Nakagawa, K; Nishii, N; Tachibana, M; Ueoka, A; Watanabe, A | 1 |
| Fukasawa, M; Fuke, C; Kawakami, Y; Miyazaki, T; Ninomiya, K | 1 |
| Arakawa, S; Doi, Y; Etoh, R; Fukae, S; Ishimatsu, T; Kawano, H; Maemura, K; Tomichi, Y | 1 |
| Fujii, K | 1 |
| Aiba, T; Inoue, YY; Ishibashi, K; Kamakura, S; Kamakura, T; Kusano, K; Miyamoto, K; Nagase, S; Nagayama, T; Noda, T; Noguchi, T; Shimizu, W; Sugimachi, M; Takaki, H; Wada, M; Yasuda, S | 1 |
| Hasebe, H; Kurebayashi, N; Murakoshi, N; Yokoya, T | 1 |
| Hamaguchi, S; Hiiro, H; Irie, M; Namekata, I; Tanaka, H | 1 |
| Kamono, M; Komatsu, R; Miyazaki, K; Onuma, Y | 1 |
| Chen, SA; Chen, YC; Chen, YJ; Higa, S; Lin, FZ; Lin, YK; Liu, CM; Lu, YY; Wu, CI | 1 |
| Iwamoto, Y; Kobayashi, T; Kojima, T; Masutani, S; Mori, H; Muraji, S; Nabeshima, T; Sumitomo, N; Taki, M; Toda, K; Yoshiba, S | 1 |
| Fujikawa, H; Hirano, Y; Shibazaki, S | 1 |
| Deguchi, N; Hamaguchi, S; Hashimoto, T; Hiiro, H; Kaneko, M; Mizoguchi, M; Namekata, I; Takahashi, Y; Tanaka, H | 1 |
| Ichikawa, T; Kishimoto, T; Kume, M; Oya, S; Sakurai, S; Shiraishi, K; Takitani, Y; Yamada, H | 1 |
7 review(s) available for lidocaine and pilsicainide
| Article | Year |
|---|---|
Profiles of aprindine, cibenzoline, pilsicainide and pirmenol in the framework of the Sicilian Gambit. The Guideline Committee for Clinical Use of Antiarrhythmic Drugs in Japan (Working Group of Arrhythmias of the Japanese Society of Electrocardiology).
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Humans; Imidazoles; Lidocaine; Piperidines | 1999 |
Ventricular pacing failure after a single oral dose of pilsicainide in a patient with a permanent pacemaker and paroxysmal atrial fibrillation.
Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Electrocardiography; Equipment Failure; Female; Humans; Lidocaine; Pacemaker, Artificial; Sick Sinus Syndrome; Time Factors | 2000 |
New antiarrhythmic agents for atrial fibrillation.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Humans; Hydantoins; Imidazoles; Imidazolidines; Lidocaine; Phenethylamines; Piperazines; Sulfonamides | 2001 |
Pilsicainide for atrial fibrillation.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Catheter Ablation; Combined Modality Therapy; Electrophysiologic Techniques, Cardiac; Humans; Lidocaine; Pulmonary Veins; Sodium Channel Blockers | 2006 |
Pilsicainide.
Topics: Anti-Arrhythmia Agents; Humans; Lidocaine; Tachycardia | 2010 |
Pilsicainide Poisoning: An Autopsy Case and Review of Literature.
Topics: Accidents; Anti-Arrhythmia Agents; Drug Overdose; Humans; Lidocaine; Male; Middle Aged | 2018 |
A case of acute pilsicainide intoxication mimicking viral encephalitis.
Topics: Acute Disease; Anti-Arrhythmia Agents; Diagnosis, Differential; Electrocardiography; Encephalitis, Viral; Humans; Lidocaine; Male; Middle Aged; Substance-Related Disorders | 2017 |
25 trial(s) available for lidocaine and pilsicainide
| Article | Year |
|---|---|
Kinetics of frequency-dependent conduction delay by class I antiarrhythmic drugs in human atrium.
Topics: Anti-Arrhythmia Agents; Aprindine; Cardiac Pacing, Artificial; Disopyramide; Electrophysiology; Female; Heart Atria; Heart Conduction System; Humans; Kinetics; Lidocaine; Male; Mexiletine; Middle Aged; Sodium Channels | 1995 |
Conversion of recent-onset Atrial Fibrillation by a single oral dose of Pilsicainide (Pilsicainide Suppression Trial on atrial fibrillation). The PSTAF Investigators.
Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Time Factors; Treatment Outcome | 1996 |
Electrophysiologic mechanisms of adverse effects of class I antiarrhythmic drugs (cibenzoline, pilsicainide, disopyramide, procainamide) in induction of atrioventricular re-entrant tachycardia.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Disopyramide; Electrophysiology; Female; Heart Conduction System; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Procainamide; Tachycardia, Atrioventricular Nodal Reentry; Wolff-Parkinson-White Syndrome | 1996 |
Electrophysiologic and hemodynamic effects of a single oral dose of pilsicainide hydrochloride, a new class 1c antiarrhythmic agent.
Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Atrial Function; Electrocardiography; Electrophysiology; Female; Heart; Hemodynamics; Humans; Lidocaine; Male; Middle Aged; Tachycardia, Supraventricular | 1998 |
Mechanism of antiarrhythmic effects of class Ic drugs in paroxysmal atrial fibrillation in man.
Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiology; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged | 1998 |
Effect of cimetidine and probenecid on pilsicainide renal clearance in humans.
Topics: Adult; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Cimetidine; Cross-Over Studies; Enzyme Inhibitors; Humans; Kidney; Lidocaine; Male; Probenecid; Reference Values; Uricosuric Agents | 2000 |
Pilsicainide for conversion and maintenance of sinus rhythm in chronic atrial fibrillation: a placebo-controlled, multicenter study.
Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Chronic Disease; Drug Administration Schedule; Electric Countershock; Female; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Premedication; Prognosis; Recurrence; Treatment Outcome | 2000 |
Single oral administration of pilsicainide versus infusion of disopyramide for termination of paroxysmal atrial fibrillation: a multicenter trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Circadian Rhythm; Disopyramide; Female; Heart Rate; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Prospective Studies; Time Factors; Treatment Outcome | 2000 |
Bepridil prevents paroxysmal atrial fibrillation by a class III antiarrhythmic drug effect.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bepridil; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged | 2003 |
Low-dose flecainide infusion followed by oral pilsicainide is highly effective and safe for paroxysmal atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Therapy, Combination; Female; Flecainide; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged | 2003 |
Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.
Topics: Aged; Anti-Asthmatic Agents; Chronic Disease; Disopyramide; Exercise; Exercise Test; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Radionuclide Imaging; Tachycardia, Ventricular; Treatment Outcome; Ventricular Dysfunction, Left | 2004 |
Hybrid therapy with pilsicainide and pulmonary vein isolation for atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Catheter Ablation; Electrophysiology; Female; Heart Atria; Heart Block; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Pulmonary Veins; Refractory Period, Electrophysiological; Salvage Therapy; Treatment Outcome | 2005 |
Population pharmacokinetic and pharmacodynamic analysis of a class IC antiarrhythmic, pilsicainide, in patients with cardiac arrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Bundle-Branch Block; Creatinine; Electrocardiography; Female; Heart Conduction System; Humans; Kidney; Lidocaine; Male; Middle Aged; Models, Biological; Sex Factors; Sodium Channel Blockers | 2006 |
Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2.
Topics: Administration, Oral; Adult; Aged; Animals; Anti-Arrhythmia Agents; Area Under Curve; Arrhythmias, Cardiac; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cation Transport Proteins; Cetirizine; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Lidocaine; Male; Oocytes; Renal Insufficiency; Xenopus | 2006 |
Pharmacological conversion of persistent atrial fibrillation into sinus rhythm with oral pilsicainide: pilsicainide suppression trial for persistent atrial fibrillation II.
Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Contraindications; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Recovery of Function; Remission Induction; Thrombosis; Warfarin | 2006 |
Randomized crossover study of the long-term effects of pilsicainide and cibenzoline in preventing recurrence of symptomatic paroxysmal atrial fibrillation: influence of the duration of arrhythmia before therapy.
Topics: Adult; Age Factors; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cross-Over Studies; Disease-Free Survival; Female; Follow-Up Studies; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Recurrence; Tachycardia; Time Factors | 2006 |
Different effect of the pure Na+ channel-blocker pilsicainide on the ST-segment response in the right precordial leads in patients with normal left ventricular function.
Topics: Adult; Aged; Algorithms; Brugada Syndrome; Electrocardiography; Female; Heart Diseases; Humans; Lidocaine; Male; Middle Aged; Prospective Studies; Sodium Channel Blockers; Ventricular Function, Left | 2007 |
Discrimination of Brugada syndrome patients from individuals with the saddle-back type ST-segment elevation using a marker of the standard 12-lead electrocardiography.
Topics: Adult; Aged; Arrhythmias, Cardiac; Biomarkers; Brugada Syndrome; Diagnosis, Differential; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers | 2007 |
Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome.
Topics: Brugada Syndrome; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Ventricular Fibrillation | 2008 |
Sodium channel blockers enhance the temporal QT interval variability in the right precordial leads in Brugada syndrome.
Topics: Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Time Factors | 2008 |
Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Natriuretic Factor; Bepridil; Drug Therapy, Combination; Electrocardiography; Female; Flecainide; Follow-Up Studies; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Natriuretic Peptide, Brain; Sinoatrial Node; Treatment Outcome | 2008 |
A randomized study on the efficacy of intravenous cibenzoline and pilsicainide administered prior to electrical cardioversion in patients with lone paroxysmal and persistent atrial fibrillation.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Natriuretic Factor; Electric Countershock; Female; Humans; Imidazoles; Injections, Intravenous; Lidocaine; Male | 2009 |
An open-label, single-dose, parallel-group, dose-increasing study comparing the pharmacokinetics and tolerability of pilsicainide hydrochloride in healthy Korean and Japanese male subjects.
Topics: Adult; Anti-Arrhythmia Agents; Area Under Curve; Asian People; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrocardiography; Humans; Japan; Korea; Lidocaine; Male; Reference Values; Young Adult | 2009 |
Predicting the efficacy of antiarrhythmic agents for interrupting persistent atrial fibrillation according to spectral analysis of the fibrillation waves on the surface ECG.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Bepridil; Cross-Over Studies; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Humans; Lidocaine; Male; Middle Aged; Sensitivity and Specificity; Spectrum Analysis; Treatment Outcome | 2009 |
Pharmacokinetics of pilsicainide hydrochloride for injection in healthy Chinese volunteers: a randomized, parallel-group, open-label, single-dose study.
Topics: Administration, Intravenous; Adult; Anti-Arrhythmia Agents; Chemistry, Pharmaceutical; China; Dose-Response Relationship, Drug; Drugs, Generic; Female; Humans; Lidocaine; Male | 2014 |
168 other study(ies) available for lidocaine and pilsicainide
| Article | Year |
|---|---|
New antiarrhythmic agents. N-aryl-8-pyrrolizidinealkanamides.
Topics: Animals; Anti-Arrhythmia Agents; Lidocaine; Male; Mice; Mice, Inbred Strains; Structure-Activity Relationship | 1985 |
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2008 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs.
Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Dinitrophenols; Disopyramide; Flecainide; Glyburide; Guinea Pigs; Heart Ventricles; Imidazoles; Lidocaine; Mexiletine; Myocardium; Piperidines; Potassium; Procainamide; Pyridines | 1992 |
[Pharmacokinetics and pharmacodynamics of class I antiarrhythmic agents after a single oral administration].
Topics: Administration, Oral; Anti-Arrhythmia Agents; Aprindine; Flecainide; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone | 1992 |
Modes of the Na channel blocking action of pilsicainide, a new antiarrhythmic agent, in cardiac cells.
Topics: Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Myocardium; Sodium Channels | 1992 |
[Clinical significance of the use-dependent sodium channel block and reverse use-dependent potassium channel block of class I and class III antiarrhythmic agents and their values to predict drug efficacy].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Electrophysiology; Exercise Test; Humans; Lidocaine; Mexiletine; Middle Aged; Potassium Channels; Sodium Channels | 1992 |
[Estimation of depressant effects of class I antiarrhythmic drugs on intraventricular conduction--rate-dependent effects on QRS duration].
Topics: Anti-Arrhythmia Agents; Aprindine; Depression, Chemical; Disopyramide; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Humans; Lidocaine; Mexiletine; Sodium Channels; Ventricular Function | 1992 |
Effects of SUN-1165, N-(2,6-dimethylphenyl)-8-pyrrolizidine acetamide hydrochloride hemihydrate, a new class I antiarrhythmic drug, on ventricular arrhythmias, intraventricular conduction, and the refractory period in canine myocardial infarction.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Electric Stimulation; Electrocardiography; Heart Conduction System; Lidocaine; Myocardial Infarction; Refractory Period, Electrophysiological; Ventricular Function | 1992 |
Mechanisms of the anticholinergic effect of SUN 1165 in comparison with flecainide, disopyramide and quinidine in single atrial myocytes isolated from guinea-pig.
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardium; Parasympatholytics; Potassium Channels; Quinidine; Receptors, Cholinergic | 1991 |
Suppressive effect of SUN1165 on supraventricular tachycardia.
Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrocardiography; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Supraventricular; Wolff-Parkinson-White Syndrome | 1991 |
Pharmacokinetics of SUN 1165, a new antiarrhythmic agent, in renal dysfunction.
Topics: Acute Kidney Injury; Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Creatinine; Female; Half-Life; Humans; Lidocaine; Male; Middle Aged | 1991 |
Canine digitalis arrhythmia as a model for detecting Na-channel blocking antiarrhythmic drugs: a comparative study using other canine arrhythmia models and the new antiarrhythmic drugs, propafenone, tocainide, and SUN 1165.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Dogs; Epinephrine; Female; Ion Channels; Lidocaine; Ligation; Male; Ouabain; Propafenone; Propiophenones; Sodium; Tocainide | 1985 |
SUN 1165: a new antiarrhythmic Na current blocker in ventricular myocytes of guinea-pig.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Ion Channels; Kinetics; Lidocaine; Male; Myocardial Contraction; Myocardium; Sodium | 1987 |
Mechanism of inhibition by SUN 1165, a new Na channel blocking antiarrhythmic agent, of cardiac glycoside-induced triggered activity.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Caffeine; Dogs; Egtazic Acid; Electric Stimulation; Female; Heart Conduction System; In Vitro Techniques; Ion Channels; Lidocaine; Male; Perfusion; Purkinje Fibers; Strophanthidin | 1988 |
Effect of SUN 1165, a new potent antiarrhythmic agent, on the kinetics of rate-dependent block of Na channels and ventricular conduction of extrasystoles.
Topics: Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Cardiac Complexes, Premature; Disopyramide; Guinea Pigs; Heart Conduction System; Heart Ventricles; In Vitro Techniques; Ion Channels; Lidocaine; Male; Mexiletine; Papillary Muscles; Piperidines; Sodium | 1988 |
Different time courses of the blockade of sodium current by lignocaine and SUN 1165 in single myocytes isolated from guinea-pig atrium.
Topics: Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; Humans; In Vitro Techniques; Lidocaine; Male; Myocardium; Sodium Channels; Time Factors | 1989 |
Effects of N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate on the ventriculo-atrial conductivity of accessory pathways.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Atrioventricular Node; Electrophysiology; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Neural Conduction; Neural Pathways; Tachycardia, Atrioventricular Nodal Reentry | 1989 |
The effects of SUN 1165, a novel sodium channel blocker, on ischemia-induced mitochondrial dysfunction and leakage of lysosomal enzymes in canine hearts.
Topics: Animals; Blood Pressure; Cattle; Coronary Disease; Female; Heart; Lidocaine; Lysosomes; Male; Mitochondria; Oxygen Consumption; Sodium Channels | 1988 |
Use-dependent blocking action of newly developed lidocaine-analogs on maximum rate of rise of action potentials in guinea pig papillary muscle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Guinea Pigs; Kinetics; Lidocaine; Mexiletine; Papillary Muscles; Structure-Activity Relationship; Tocainide | 1987 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Temperature; Catalepsy; Cats; Central Nervous System; Chemical Phenomena; Chemistry; Disopyramide; Dogs; Electroencephalography; Female; Hypothermia; Lidocaine; Male; Mexiletine; Mice; Motor Activity; Muscle Relaxation; Pain; Rabbits; Rats; Rats, Inbred Strains; Seizures; Tremor; Vomiting | 1988 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 2nd communication: effect on the peripheral nervous system and peripheral organs.
Topics: Animals; Anti-Arrhythmia Agents; Autonomic Nervous System; Capillary Permeability; Chemical Phenomena; Chemistry; Digestive System; Disopyramide; Endocrine Glands; Female; Gastric Mucosa; Gastrointestinal Motility; Guinea Pigs; Ileum; Lidocaine; Male; Mexiletine; Mice; Peripheral Nerves; Pregnancy; Pupil; Rabbits; Rats; Rats, Inbred Strains; Trachea; Urinary Bladder; Urogenital System; Uterus; Vas Deferens | 1988 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 3rd communication: effect on cardiovascular system.
Topics: Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Blood Pressure; Cardiac Output; Chemical Phenomena; Chemistry; Dogs; Energy Metabolism; Female; Heart; Heart Rate; Hemodynamics; Kidney; Lidocaine; Male; Myocardial Contraction; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Respiration | 1988 |
N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165): a new potent and long-acting antiarrhythmic agent.
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cell Membrane; Coronary Circulation; Coronary Vessels; Disopyramide; Dogs; Epinephrine; Female; Guinea Pigs; Halothane; In Vitro Techniques; Lidocaine; Male; Myocardial Contraction; Ouabain; Papillary Muscles | 1985 |
N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165), a new antiarrhythmic agent: effects on cardiac conduction.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Duodenum; Electrocardiography; Female; Heart Conduction System; In Vitro Techniques; Infusions, Parenteral; Injections; Injections, Intra-Arterial; Injections, Intravenous; Lidocaine; Male; Rabbits; Refractory Period, Electrophysiological | 1985 |
Effects of a new antiarrhythmic compound SUN 1165 [N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride] on the sodium currents in isolated single rat ventricular cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Heart; In Vitro Techniques; Ion Channels; Lidocaine; Microelectrodes; Myocardium; Rats; Sodium | 1984 |
Ischemia enhances use-dependent sodium channel blockade by pilsicainide, a class IC antiarrhythmic agent.
Topics: Acute Disease; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chi-Square Distribution; Drug Evaluation; Electrocardiography; Exercise Test; Female; Humans; Lidocaine; Male; Middle Aged; Myocardial Ischemia; Risk Factors; Sodium Channels | 1994 |
Slow abnormal conduction in the low right atrium: its anatomic basis and relevance to atrial reentry.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Atrial Function, Right; Dogs; Electric Stimulation; Electrocardiography; Female; Heart Atria; Heart Block; Heart Conduction System; Lidocaine; Male; Piperidines; Pyridines; Refractory Period, Electrophysiological; Time Factors | 1994 |
Effects of pilsicainide on systemic hemodynamics and cardiac function of anesthetized dogs.
Topics: Anesthesia, Intravenous; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Dogs; Female; Flecainide; Heart; Hemodynamics; Lidocaine; Male; Myocardial Contraction; Propafenone | 1993 |
[Effect of pilsicainide hydrochloride on atrial fibrillation threshold].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged | 1993 |
Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class Ic antiarrhythmic agents.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Creatine Kinase; Flecainide; Heart; Lidocaine; Male; Metals; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rats; Rats, Wistar; Ventricular Function, Left | 1993 |
Clinical evaluation of the use-dependent QRS prolongation and the reverse use-dependent QT prolongation of class I and class III antiarrhythmic agents and their value in predicting efficacy.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Exercise Test; Female; Heart Rate; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Piperidines; Potassium Channels; Pyridines; Sodium Channels | 1993 |
Effects of pilsicainide on the atrial fibrillation threshold in guinea pig atria. A comparative study with disopyramide, lidocaine and flecainide.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Electrophysiology; Female; Flecainide; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Male | 1993 |
Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes.
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Disopyramide; Electric Conductivity; Flecainide; Guinea Pigs; Lidocaine; Male; Myocardium; Potassium; Potassium Channels; Propafenone | 1993 |
Mechanisms of negative inotropic effects of class Ic antiarrhythmic agents: comparative study of the effects of flecainide and pilsicainide on intracellular calcium handling in dog ventricular myocardium.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Calcium Channels; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Flecainide; Heart Ventricles; Lidocaine; Myocardial Contraction; Myocardium; Sarcolemma | 1996 |
Idiopathic ventricular fibrillation initiated by a short-coupled ventricular premature beat.
Topics: Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Humans; Lidocaine; Male; Propranolol; Ventricular Fibrillation; Verapamil | 1996 |
The rise time of the monophasic action potential--a new index of local use-dependent conductivity by sodium channel blockers in human myocardium.
Topics: Action Potentials; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Disopyramide; Female; Heart; Heart Conduction System; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Sodium Channels | 1997 |
Different effects of class Ic and III antiarrhythmic drugs on vagotonic atrial fibrillation in the canine heart.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Dogs; Electric Stimulation; Female; Lidocaine; Male; Pyrimidinones; Vagus Nerve | 1998 |
Class I antiarrhythmic drugs alter the severity of myocardial stunning by modulating ATP-sensitive K+ channels in guinea pig ventricular muscles.
Topics: Animals; Anti-Arrhythmia Agents; Glyburide; Guinea Pigs; Heart; Heart Ventricles; Imidazoles; Lidocaine; Male; Mexiletine; Myocardial Stunning; Potassium Channels | 1998 |
[Efficacy and safety of a single oral dose of pilsicainide in supraventricular arrhythmia after coronary artery bypass grafting].
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Coronary Artery Bypass; Female; Humans; Lidocaine; Male; Middle Aged; Postoperative Complications; Tachycardia, Supraventricular | 1998 |
Uniqueness of pilsicainide in class Ic antiarrhythmics.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Function; Calcium Channels; Dose-Response Relationship, Drug; Heart Atria; Lidocaine; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Rabbits | 1998 |
Class IC antiarrhythmic drugs, flecainide and pilsicainide, produce ST segment elevation simulating inferior myocardial ischemia.
Topics: Anti-Arrhythmia Agents; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Flecainide; Heart; Humans; Lidocaine; Male; Middle Aged; Myocardial Ischemia; Tachycardia, Ventricular | 1998 |
Effects of pilsicainide and propafenone on vagally induced atrial fibrillation: role of suppressant effect in conductivity.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Output; Dogs; Electric Conductivity; Electric Stimulation; Electrophysiology; Female; Heart Atria; Heart Rate; Humans; Lidocaine; Male; Propafenone; Vagus Nerve | 1998 |
Postrepolarization refractoriness as a potential anti-atrial fibrillation mechanism of pilsicainide, a pure sodium channel blocker with slow recovery kinetics.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Dogs; Drug Evaluation, Preclinical; Female; Kinetics; Lidocaine; Male; Sodium Channel Blockers | 1998 |
Dispersion of signal-averaged P wave duration on precordial body surface in patients with paroxysmal atrial fibrillation.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Body Surface Potential Mapping; Female; Follow-Up Studies; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Prognosis; Prospective Studies; Recurrence; ROC Curve; Tachycardia, Paroxysmal | 1999 |
ST segment elevation in the right precordial leads induced with class IC antiarrhythmic drugs: insight into the mechanism of Brugada syndrome.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Flecainide; Follow-Up Studies; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Procainamide; Recurrence; Tachycardia, Paroxysmal; Tachycardia, Ventricular; Wolff-Parkinson-White Syndrome | 1999 |
Pilsicainide intoxication in a patient with dehydration.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Dehydration; Electrocardiography; Female; Humans; Lidocaine; Poisoning | 1999 |
Effect of pilsicainide, a pure sodium channel blocker, on spiral waves during atrial fibrillation: theoretical analysis by numerical simulation.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Computer Simulation; Culture Techniques; Electrocardiography; Heart Atria; Humans; Lidocaine; Signal Processing, Computer-Assisted; Sodium Channel Blockers; Sodium Channels | 1999 |
Determination of refractory periods and conduction velocity during atrial fibrillation using atrial capture in dogs: direct assessment of the wavelength and its modulation by a sodium channel blocker, pilsicainide.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Female; Lidocaine; Male; Signal Processing, Computer-Assisted; Sodium Channels | 2000 |
Selective block of late currents in the DeltaKPQ Na(+) channel mutant by pilsicainide and lidocaine with distinct mechanisms.
Topics: Animals; Anti-Arrhythmia Agents; Cells, Cultured; Cricetinae; Electrophysiology; Humans; Lidocaine; Long QT Syndrome; Myocardium; Sodium Channel Blockers; Sodium Channels; Transfection | 2000 |
Effect of Valsalva maneuver on surface electrocardiographic P-wave dispersion in paroxysmal atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Prognosis; Sympathetic Nervous System; Tachycardia, Paroxysmal; Valsalva Maneuver | 2000 |
Transient appearance of antegrade conduction via an AV accessory pathway caused by atrial fibrillation in a patient with intermittent Wolff-Parkinson-White syndrome.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Electrocardiography; Heart Conduction System; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged; Procainamide; Wolff-Parkinson-White Syndrome | 2000 |
[Antiarrhythmic effects of pilsicainide hydrochloride and effects on cardiac function and ECG in dogs: comparison with disopyramide].
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disease Models, Animal; Disopyramide; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Hemodynamics; Infusions, Intravenous; Lidocaine; Ligation | 2000 |
A case of sinus pause due to the proarrhythmia of pilsicainide.
Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Consciousness Disorders; Electrocardiography; Humans; Lidocaine; Male; Sodium Channel Blockers | 2000 |
QT-prolonging class I drug, disopyramide, does not aggravate but suppresses adrenaline-induced arrhythmias. Comparison with cibenzoline and pilsicainide.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Disopyramide; Dogs; Drug Interactions; Electrocardiography; Epinephrine; Female; Heart Rate; Imidazoles; Lidocaine; Male | 2000 |
Effect of a single oral dose of pilsicainide on pacing thresholds in pacemaker patients with and without paroxysmal atrial fibrillation.
Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Pacing, Artificial; Drug Evaluation; Female; Humans; Lidocaine; Male; Pacemaker, Artificial | 2000 |
ST segment elevation in the right precordial leads following administration of class Ic antiarrhythmic drugs.
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Retrospective Studies | 2001 |
Relatively benign clinical course in asymptomatic patients with brugada-type electrocardiogram without family history of sudden death.
Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Death, Sudden, Cardiac; Electrocardiography; Electrophysiology; Follow-Up Studies; Humans; Lidocaine; Male; Medical Records; Middle Aged; Neural Conduction; Prognosis; Reaction Time; Syndrome; Ventricular Fibrillation | 2001 |
Syncope in patients with atrial flutter during treatment with class Ic antiarrhythmic drugs.
Topics: Adult; Anti-Arrhythmia Agents; Atrial Flutter; Catheter Ablation; Electrocardiography; Electrophysiologic Techniques, Cardiac; Exercise; Flecainide; Humans; Lidocaine; Male; Middle Aged; Syncope; Tachycardia | 2001 |
Appropriate dosing of pilsicainide hydrochloride in patients on hemodialysis.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Premature Complexes; Echocardiography; Electrocardiography, Ambulatory; Female; Humans; Kidney Failure, Chronic; Lidocaine; Male; Middle Aged; Renal Dialysis | 2001 |
ELISA for the quantification of pilsicainide.
Topics: Animals; Anti-Arrhythmia Agents; beta-Galactosidase; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin G; Indicators and Reagents; Lidocaine; Rabbits; Spectrophotometry, Infrared | 2001 |
[Efficacy of pilsicainide for the long-term prevention of paroxysmal atrial fibrillation: analysis based on the time of onset].
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; Female; Humans; Hypertension; Lidocaine; Male; Time | 2001 |
Effects of ionic remodeling on cardiac antiarrhythmic drug actions.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Down-Regulation; Electric Conductivity; Heart Failure; Humans; Ion Channels; Ion Transport; Lidocaine; Potassium Channel Blockers; Refractory Period, Electrophysiological; Tachycardia, Ectopic Atrial; Torsades de Pointes | 2001 |
Electropharmacologic effects of pilsicainide, a pure sodium channel blocker, on the remodeled atrium subjected to chronic rapid pacing.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Cardiac Pacing, Artificial; Chronic Disease; Dogs; Electrodes, Implanted; Female; Lidocaine; Male; Neural Conduction; Refractory Period, Electrophysiological; Sodium Channel Blockers; Time Factors | 2001 |
Images in cardiology: Successful treatment of atrial tachycardia-induced cardiomyopathy with pilsicainide.
Topics: Adolescent; Anti-Arrhythmia Agents; Cardiomegaly; Female; Humans; Lidocaine; Radiography; Stroke Volume; Tachycardia | 2001 |
Paradoxic abbreviation of repolarization in epicardium of the right ventricular outflow tract during augmentation of Brugada-type ST segment elevation.
Topics: Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiotonic Agents; Electrocardiography; Heart Ventricles; Humans; Isoproterenol; Lidocaine; Male; Middle Aged; Syndrome; Ventricular Fibrillation; Ventricular Function, Right | 2001 |
Class I antiarrhythmic drug and coronary vasospasm-induced T wave alternans and ventricular tachyarrhythmia in a patient with Brugada syndrome and vasospastic angina.
Topics: Acetylcholine; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Bundle-Branch Block; Humans; Lidocaine; Male; Middle Aged; Tachycardia, Ventricular; Vasodilator Agents; Ventricular Premature Complexes | 2002 |
J wave and ST segment elevation in the inferior leads: a latent type of variant Brugada syndrome?
Topics: Adult; Bundle-Branch Block; Diagnosis, Differential; Electrocardiography; Humans; Lidocaine; Male; Sodium Channel Blockers; Syndrome; Tachycardia, Ventricular; Ventricular Fibrillation | 2002 |
Quantification of pilsicainide in serum by capillary electrophoresis.
Topics: Anti-Arrhythmia Agents; Electrophoresis, Capillary; Humans; Lidocaine; Reproducibility of Results; Sensitivity and Specificity | 2002 |
Pilsicanide-induced marked T wave alternans and ventricular fibrillation in a patient with Brugada syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Electrocardiography; Humans; Lidocaine; Long QT Syndrome; Male; Syndrome; Ventricular Fibrillation | 2002 |
[Brugada syndrome occurring in an identical twin: a case report].
Topics: Anti-Arrhythmia Agents; Bundle-Branch Block; Diseases in Twins; Electrocardiography; Humans; Lidocaine; Male; Middle Aged; NAV1.5 Voltage-Gated Sodium Channel; Sodium Channels; Syndrome; Twins, Monozygotic; Ventricular Fibrillation | 2002 |
Atrial fibrillation threshold predicted long-term efficacy of pharmacological treatment of patients without structural heart disease.
Topics: Aged; Anti-Arrhythmia Agents; Aprindine; Atrial Fibrillation; Disopyramide; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Treatment Outcome | 2002 |
Evaluation of the effect of bepridil on paroxysmal atrial fibrillation: relationship between efficacy and the f-f interval in surface ECG recordings.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Bepridil; Calcium Channel Blockers; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Treatment Outcome | 2003 |
Widening of the excitable gap and enlargement of the core of reentry during atrial fibrillation with a pure sodium channel blocker in canine atria.
Topics: Acetylcholine; Animals; Atrial Fibrillation; Body Surface Potential Mapping; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart Atria; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Sodium Channel Blockers | 2003 |
Therapeutic monitoring of class I antiarrhythmic agents using high-resolution electrocardiography instead of blood samples.
Topics: Aged; Anti-Arrhythmia Agents; Drug Monitoring; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Piperidines | 2003 |
Risk stratification for asymptomatic patients with Brugada syndrome.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiac Pacing, Artificial; Electrocardiography; Follow-Up Studies; Heart; Humans; Lidocaine; Male; Middle Aged; Prognosis; Risk Assessment; Ventricular Fibrillation | 2003 |
Effect of pilsicainide on atrial electrophysiologic properties in the canine rapid atrial stimulation model.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Cardiac Pacing, Artificial; Diastole; Differential Threshold; Dogs; Electrophysiology; Heart Rate; Lidocaine; Refractory Period, Electrophysiological; Ventricular Function | 2003 |
Enhancement of J-ST-segment elevation by the glucose and insulin test in Brugada syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Bundle-Branch Block; Electrocardiography; Glucose; Heart Arrest; Humans; Insulin; Lidocaine; Male; Middle Aged; Syncope; Syndrome; Ventricular Fibrillation | 2003 |
Intravenous administration of class I antiarrhythmic drug induced T wave alternans in an asymptomatic Brugada syndrome patient.
Topics: Amiodarone; Anti-Arrhythmia Agents; Bundle-Branch Block; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiologic Techniques, Cardiac; Humans; Lidocaine; Male; Middle Aged; Signal Processing, Computer-Assisted; Syndrome; Ventricular Fibrillation | 2003 |
Right bundle branch block and coved-type ST-segment elevation mimicked by acute cholecystitis.
Topics: Aged; Bundle-Branch Block; Cholecystitis, Acute; Diagnosis, Differential; Electrocardiography; Female; Humans; Injections, Intravenous; Lidocaine; Sodium Channel Blockers | 2003 |
Effects of Na+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.
Topics: Action Potentials; Cation Transport Proteins; Cells, Cultured; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Lidocaine; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Sodium Channel Blockers; Trans-Activators; Transcriptional Regulator ERG | 2003 |
[Factors for successful conversion of atrial fibrillation using intravenous injection of pilsicainide hydrochloride].
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged | 2003 |
Ventricular arrhythmia induced by sodium channel blocker in patients with Brugada syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bundle-Branch Block; Electrocardiography; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers | 2003 |
[Brugada syndrome associated with ventricular fibrillation induced by administration of pilsicainide: a case report].
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Electrophysiology; Humans; Lidocaine; Male; Middle Aged; Syndrome; Ventricular Fibrillation | 2003 |
Mechanism of ST elevation and ventricular arrhythmias in an experimental Brugada syndrome model.
Topics: Animals; Disease Models, Animal; Dogs; Electrocardiography; Female; In Vitro Techniques; Lidocaine; Male; Pinacidil; Potassium Channels; Sodium Channel Blockers; Syndrome; Tachycardia, Ventricular | 2004 |
Brugada-like electrocardiographic pattern unmasked by fever.
Topics: Adult; Body Temperature; Bundle-Branch Block; Electrocardiography; Fever; Humans; Lidocaine; Male; Sodium Channel Blockers; Sodium Channels; Syndrome | 2004 |
Brugada syndrome-like ST-segment elevation increase exacerbated by vomiting.
Topics: Acetylcholine; Anti-Arrhythmia Agents; Coronary Vessels; Electrocardiography; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Syndrome; Ventricular Fibrillation; Vomiting | 2004 |
The effects of class Ic antiarrhythmics on tetrodotoxin-resistant Na+ currents in rat sensory neurons.
Topics: Algorithms; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Drug Interactions; Drug Resistance; Flecainide; Ganglia, Spinal; Lidocaine; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2004 |
Differentiation of the electrophysiological effects on the atrial myocardium between the pure Na channel blocker, pilsicainide, and flecainide.
Topics: Adult; Anti-Arrhythmia Agents; Atrial Flutter; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Heart Atria; Heart Conduction System; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Myocardium; Prospective Studies; Refractory Period, Electrophysiological; Research Design; Sodium Channel Blockers; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Ventricular; Treatment Outcome; Wolff-Parkinson-White Syndrome | 2004 |
Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Disease Models, Animal; Electrocardiography; Hemodynamics; KATP Channels; Lidocaine; Mexiletine; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rabbits; Sarcolemma; Sodium Channel Blockers; Stroke Volume; Ventricular Function, Left | 2004 |
Pilsicainide in breast milk from a mother: comparison with disopyramide and propafenone.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Breast Feeding; Disopyramide; Female; Humans; Lidocaine; Milk, Human; Propafenone | 2005 |
Effects of the NA+ channel blocker pilsicainide on the electrophysiologic properties of pulmonary veins in patients with atrial fibrillation.
Topics: Atrial Fibrillation; Electrophysiologic Techniques, Cardiac; Female; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Pulmonary Veins; Sodium Channel Blockers; Treatment Outcome | 2004 |
A case of the toxicity of pilsicainide hydrochloride with comparison of the serial serum pilsicainide levels and electrocardiographic findings.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Creatinine; Drug Overdose; Electrocardiography; Humans; Lidocaine; Male; Tachycardia, Ventricular | 2004 |
Three elderly cases with Brugada-type electrocardiographic pattern unmasked by pilsicainide at the toxic level.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Electrocardiography; Heart Block; Humans; Kidney Failure, Chronic; Lidocaine; Male | 2005 |
A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.
Topics: Animals; Atrial Fibrillation; Cardiac Pacing, Artificial; Disease Models, Animal; Electrocardiography; Lidocaine; Male; Rats; Rats, Sprague-Dawley | 2005 |
Pilsicainide-induced coronary vasospasm in a patient with Brugada-type electrocardiogram.
Topics: Aged; Anti-Arrhythmia Agents; Coronary Angiography; Coronary Vasospasm; Electrocardiography; Heart Arrest; Humans; Injections, Intravenous; Lidocaine; Male | 2005 |
Effect of protein binding of pilsicainide on the pharmacokinetics.
Topics: Aged; Anti-Arrhythmia Agents; C-Reactive Protein; Chromatography, High Pressure Liquid; Creatinine; Humans; Lidocaine; Middle Aged; Orosomucoid; Protein Binding | 2005 |
Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Electrocardiography; Heart Atria; Lidocaine; Male; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Thyrotoxicosis; Thyroxine | 2005 |
Long-term efficacy of hybrid pharmacologic and ablation therapy in patients with pilsicainide-induced atrial flutter.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Cardiac Pacing, Artificial; Catheter Ablation; Combined Modality Therapy; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Follow-Up Studies; Humans; Lidocaine; Male; Middle Aged; Prospective Studies; Sodium Channel Blockers; Treatment Outcome | 2005 |
Heart rate variability is a useful parameter for evaluation of anticholinergic effect associated with inducibility of atrial fibrillation.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Cholinergic Antagonists; Disopyramide; Dogs; Electrocardiography; Heart Atria; Heart Conduction System; Heart Rate; Lidocaine; Treatment Outcome | 2005 |
[Case in which magnesium sulfate effectively treated ventricular tachycardia due to overdose of pilsicainide hydrochloride].
Topics: Adult; Anti-Asthmatic Agents; Drug Overdose; Hemoperfusion; Humans; Infusions, Intravenous; Lidocaine; Magnesium Sulfate; Male; Suicide, Attempted; Tachycardia, Ventricular; Treatment Outcome | 2006 |
Pilsicainide-induced verapamil sensitive idiopathic left ventricular tachycardia.
Topics: Adult; Anti-Arrhythmia Agents; Drug Combinations; Electrocardiography; Humans; Lidocaine; Male; Tachycardia, Ventricular; Ventricular Dysfunction, Left; Verapamil | 2006 |
Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography; Electrophysiologic Techniques, Cardiac; Endocardium; Heart Conduction System; Heart Diseases; Heart Ventricles; Lidocaine; Male; Pericardium; Pinacidil; Tachycardia, Ventricular; Terfenadine; Ventricular Fibrillation | 2006 |
The full stomach test as a novel diagnostic technique for identifying patients at risk of Brugada syndrome.
Topics: Adult; Brugada Syndrome; Circadian Rhythm; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart; Humans; Lidocaine; Male; Middle Aged; Postprandial Period; Predictive Value of Tests; Sodium Channel Blockers; Stomach; Syncope; Vagus Nerve; Ventricular Fibrillation | 2006 |
Effects of antiarrhythmic drugs on apoptotic pathways in H9c2 cardiac cells.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Apoptosis; Caspases; Cell Line; Clone Cells; Diploidy; DNA Fragmentation; Dose-Response Relationship, Drug; Lidocaine; Membrane Potentials; Mitochondrial Membranes; Propranolol; Pyrimidinones; Signal Transduction; Time Factors; Verapamil | 2006 |
Spontaneous polymorphic ventricular tachycardia after administration of pilsicainide in a patient resuscitated from ventricular fibrillation.
Topics: Adult; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Electric Countershock; Humans; Lidocaine; Tachycardia, Ventricular; Ventricular Fibrillation | 2006 |
High-frequency potentials developed in wavelet-transformed electrocardiogram as a novel indicator for detecting Brugada syndrome.
Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Aged; Anti-Arrhythmia Agents; Brugada Syndrome; Cilostazol; Electrocardiography; Heart Conduction System; Humans; Isoproterenol; Lidocaine; Male; Middle Aged; Research Design; Tetrazoles; Time Factors; Vasodilator Agents | 2006 |
Comment on severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency.
Topics: Aged; Area Under Curve; Arrhythmias, Cardiac; Cetirizine; Drug Interactions; Female; Half-Life; Humans; Lidocaine; Metabolic Clearance Rate; Renal Insufficiency | 2006 |
Multiple premature beats triggered ventricular arrhythmias during pilsicainide infusion in a patient with inferior ST-segment elevation.
Topics: Adolescent; Anti-Arrhythmia Agents; Atrial Flutter; Electrocardiography; Humans; Infusions, Intravenous; Lidocaine; Male; Ventricular Fibrillation; Ventricular Premature Complexes | 2006 |
Temperature modulation of ventricular arrhythmogenicity in a canine tissue model of Brugada syndrome.
Topics: Action Potentials; Animals; Body Temperature; Brugada Syndrome; Disease Models, Animal; Dogs; Electrocardiography; Fever; Hypothermia, Induced; Lidocaine; Ventricular Dysfunction | 2007 |
How can a single mutation cause such arrhythmic havoc?
Topics: Action Potentials; Animals; Body Temperature; Brugada Syndrome; Disease Models, Animal; Dogs; Electrocardiography; Fever; Hypothermia, Induced; Ion Channels; Lidocaine; Mutation; Ventricular Dysfunction | 2007 |
Pilsicainide-induced ventricular tachycardia originating from right ventricular outflow tract.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Female; Humans; Lidocaine; Middle Aged; Tachycardia, Ventricular | 2007 |
Incidence and initial characteristics of pilsicainide-induced ventricular arrhythmias in patients with Brugada syndrome.
Topics: Adult; Aged; Arrhythmias, Cardiac; Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Humans; Incidence; Lidocaine; Male; Middle Aged; Sodium Channel Blockers | 2007 |
[Elderly Brugada syndrome with recurrent syncope, diagnosed by pilsicainide challenge test].
Topics: Aged; Brugada Syndrome; Electrocardiography; Humans; Lidocaine; Male; Recurrence; Syncope | 2007 |
Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein.
Topics: Acetylcholine; Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Dogs; Electric Stimulation; Electroencephalography; Heart Atria; Lidocaine; Male; Pulmonary Veins; Vagus Nerve; Vasodilator Agents | 2007 |
Pilsicainide-induced Brugada-type ECG and ventricular arrhythmias originating from the left posterior fascicle in a case with Brugada syndrome associated with idiopathic left ventricular tachycardia.
Topics: Anti-Arrhythmia Agents; Brugada Syndrome; Catheter Ablation; Electrocardiography; Electrophysiologic Techniques, Cardiac; Humans; Lidocaine; Male; Middle Aged; Tachycardia, Ventricular; Ventricular Septum | 2008 |
Clinical and electrophysiological characteristics of patients having atrial flutter with 1:1 atrioventricular conduction.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Flutter; Case-Control Studies; Catheter Ablation; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Heart Atria; Heart Conduction System; Heart Ventricles; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Retrospective Studies; Risk Factors | 2008 |
Re: Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome.
Topics: Brugada Syndrome; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Ventricular Fibrillation | 2008 |
Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 electrocardiogram in patients with Brugada syndrome.
Topics: Action Potentials; Adult; Aged; Brugada Syndrome; Case-Control Studies; Electrocardiography; Endocardium; Female; Heart Conduction System; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Pericardium; Sodium Channel Blockers | 2008 |
Menstruation-dependent idiopathic ventricular arrhythmia.
Topics: Adult; Anti-Asthmatic Agents; Electrocardiography, Ambulatory; Female; Humans; Lidocaine; Menstruation; Propranolol; Ventricular Premature Complexes | 2008 |
Acute fatal poisoning with pilsicainide and atenolol.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Chromatography, High Pressure Liquid; Depression; Female; Fibrosis; Forensic Pathology; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Lidocaine; Lung; Myocytes, Cardiac; Nephritis, Interstitial; Pulmonary Edema; Sodium Channel Blockers; Suicide; Young Adult | 2008 |
Action potential alternans in the right ventricular outflow tract in a patient with asymptomatic Brugada syndrome.
Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Lidocaine; Male; Ventricular Fibrillation; Ventricular Function, Right | 2009 |
Pilsicainide intoxication presenting as left ventricular dyssynchrony in a patient on hemodialysis.
Topics: Aged; Anti-Arrhythmia Agents; Diagnosis, Differential; Humans; Lidocaine; Male; Renal Dialysis; Ventricular Dysfunction, Left | 2009 |
Effect of pilsicainide on dominant frequency in the right and left atria and pulmonary veins during atrial fibrillation: association with its atrial fibrillation terminating effect.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Catheter Ablation; Echocardiography; Electrophysiologic Techniques, Cardiac; Fasting; Female; Heart Atria; Humans; Lidocaine; Male; Middle Aged; Pulmonary Veins; Treatment Outcome | 2009 |
Early termination of spiral wave reentry by combined blockade of Na+ and L-type Ca2+ currents in a perfused two-dimensional epicardial layer of rabbit ventricular myocardium.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Heart Rate; Heart Ventricles; Lidocaine; Pericardium; Rabbits; Sodium Channel Blockers; Sodium Channels; Tachycardia, Sinoatrial Nodal Reentry; Treatment Outcome; Verapamil | 2009 |
Mapping ventricular fibrillation: a simplified experimental model leads to a complicated result.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Heart Rate; Heart Ventricles; Lidocaine; Pericardium; Rabbits; Sodium Channel Blockers; Sodium Channels; Tachycardia, Ventricular; Treatment Outcome; Verapamil | 2009 |
Ischemia-induced Brugada-type ST-segment alternans and Brugada syndrome.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Brugada Syndrome; Bundle-Branch Block; Coronary Artery Disease; Diagnosis, Differential; Electrocardiography; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Myocardial Ischemia; Prospective Studies; Sodium Channel Blockers | 2010 |
Pilsicainide-induced ST segment elevation and ST segment depression in two patients with variant forms of Brugada-type electrocardiographic abnormalities.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Injections, Intravenous; Lidocaine; Male; Ventricular Premature Complexes | 2009 |
Simultaneous assessment of pharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects on atria of chronic atrioventricular block dogs.
Topics: Administration, Cutaneous; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrioventricular Block; Dogs; Female; Heart Atria; Lidocaine; Male | 2009 |
A predictor of positive drug provocation testing in individuals with saddle-back type ST-segment elevation.
Topics: Action Potentials; Adult; Brugada Syndrome; Electrocardiography; Female; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Predictive Value of Tests; ROC Curve; Sensitivity and Specificity; Sodium Channel Blockers; Time Factors | 2009 |
Ventricular late potential in patients with apparently normal electrocardiogram; predictor of Brugada syndrome.
Topics: Adult; Aged; Aged, 80 and over; Brugada Syndrome; Chi-Square Distribution; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Predictive Value of Tests; Retrospective Studies; ROC Curve; Sodium Channel Blockers; Statistics, Nonparametric; Syncope; Ventricular Premature Complexes | 2010 |
Conduction delay in right ventricle as a marker for identifying high-risk patients with Brugada syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Coronary Sinus; Death, Sudden, Cardiac; Electrocardiography; Electrophysiology; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Observer Variation; Risk Assessment; Sodium Channel Blockers; Ventricular Function, Right | 2010 |
A novel microsatellite polymorphism of sodium channel beta1-subunit gene (SCN1B) may underlie abnormal cardiac excitation manifested by coved-type ST-elevation compatible with Brugada syndrome in Japanese.
Topics: Adult; Age Factors; Aged; Asian People; Brugada Syndrome; Electrocardiography; Female; Genetic Predisposition to Disease; Humans; Japan; Lidocaine; Logistic Models; Male; Microsatellite Repeats; Middle Aged; Muscle Proteins; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Polymorphism, Genetic; Risk Factors; Sex Factors; Sodium Channel Blockers; Sodium Channels; Voltage-Gated Sodium Channel beta-1 Subunit; Voltage-Gated Sodium Channel beta-2 Subunit | 2010 |
Genotype-phenotype correlation in tissue models of Brugada syndrome simulating patients with sodium and calcium channelopathies.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Body Surface Potential Mapping; Brugada Syndrome; Calcium Channel Blockers; Channelopathies; Dogs; Endocardium; Genotype; Isoproterenol; Lidocaine; Male; Pericardium; Phenotype; Pinacidil; Sodium Channels; Tissue Culture Techniques; Vasodilator Agents; Verapamil | 2010 |
What variables were associated with the inducibility of ventricular fibrillation during electrophysiologic stimulation test in patients without apparent organic heart disease?
Topics: Brugada Syndrome; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Ventricular Fibrillation | 2010 |
Ventricular fibrillation diagnosed during electrophysiological study for non-sustained tachycardia.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Japan; Lidocaine; Male; Occupational Health; Tachycardia, Ventricular; Time Factors; Ventricular Fibrillation | 2010 |
Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.
Topics: Brain; Cell Line; Flecainide; Heart; Humans; Lidocaine; Mexiletine; Muscle Proteins; Muscle, Skeletal; NAV1.1 Voltage-Gated Sodium Channel; NAV1.4 Voltage-Gated Sodium Channel; NAV1.5 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Patch-Clamp Techniques; Sodium Channel Blockers; Sodium Channels | 2010 |
Comparison of acute reduction in left ventricular outflow tract pressure gradient in obstructive hypertrophic cardiomyopathy by disopyramide versus pilsicainide versus cibenzoline.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathy, Hypertrophic; Disopyramide; Echocardiography, Doppler; Female; Humans; Imidazoles; Lidocaine; Linear Models; Male; Middle Aged; Propranolol; Prospective Studies; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Pressure; Verapamil | 2010 |
[Two elderly case reports of renal excretion type drug poisoning caused by dehydration that was due to poor eating in home care].
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dehydration; Feeding and Eating Disorders; Female; Home Care Services; Humans; Lidocaine; Palliative Care; Rectal Neoplasms | 2010 |
A new criteria differentiating type 2 and 3 Brugada patterns from ordinary incomplete right bundle branch block.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Bundle-Branch Block; Diagnosis, Differential; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged | 2011 |
A sodium channel blocker, pilsicainide, produces atrial post-repolarization refractoriness through the reduction of sodium channel availability.
Topics: Action Potentials; Animals; Guinea Pigs; Heart Atria; In Vitro Techniques; Kinetics; Lidocaine; Male; Refractory Period, Electrophysiological; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2011 |
Right ventricular dysfunction in patients with Brugada-like electrocardiography: a two dimensional strain imaging study.
Topics: Brugada Syndrome; Echocardiography; Elasticity Imaging Techniques; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Sodium Channel Blockers; Ventricular Dysfunction, Right | 2011 |
Pilsicainide-induced polymorphic ventricular tachycardia.
Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Electrocardiography; Female; Humans; Lidocaine; Tachycardia, Ventricular | 2012 |
Rate-dependent and site-specific conduction block at the posterior right atrium and drug effects evaluated using a noncontact mapping system in patients with typical atrial flutter.
Topics: Action Potentials; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Flutter; Cardiac Pacing, Artificial; Catheter Ablation; Electrophysiologic Techniques, Cardiac; Female; Heart Atria; Heart Block; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Predictive Value of Tests; Sodium Channel Blockers; Time Factors; Voltage-Sensitive Dye Imaging | 2012 |
Electrophysiological effects of the class Ic antiarrhythmic drug pilsicainide on the guinea-pig pulmonary vein myocardium.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Function, Left; Electrophysiological Phenomena; Female; Guinea Pigs; Heart Atria; Lidocaine; Male; Myocardium; Pulmonary Veins; Treatment Outcome | 2012 |
Pharmacologic atrial defibrillation by drug delivery into the temporarily occluded coronary sinus. A canine study.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Balloon Occlusion; Cardiac Pacing, Artificial; Chronic Disease; Coronary Sinus; Dogs; Drug Delivery Systems; Injections, Intravenous; Lidocaine; Pyrimidinones; Treatment Outcome | 2012 |
Cardiohemodynamic and electrophysiological effects of anti-influenza drug oseltamivir in vivo and in vitro.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antiviral Agents; Arterial Pressure; Cardiac Pacing, Artificial; Coronary Circulation; Dogs; Electrocardiography; Female; Guinea Pigs; Heart Atria; Hemodynamics; Humans; In Vitro Techniques; Influenza, Human; Lidocaine; Male; Myocardial Contraction; Oseltamivir; Refractory Period, Electrophysiological | 2013 |
Electrophysiological effects of an anti-influenza drug oseltamivir on the guinea-pig atrium: comparison with those of pilsicainide.
Topics: Animals; Anti-Arrhythmia Agents; Antiviral Agents; Atrial Fibrillation; Atrial Function; Atrial Function, Left; Atrial Function, Right; Electrophysiological Phenomena; Guinea Pigs; Heart Atria; Humans; Influenza, Human; Lidocaine; Oseltamivir; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sodium Channel Blockers | 2013 |
Altered responses to vasopressors of a patient medicated with carvedilol, pilsicainide and enalapril.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Atrial Fibrillation; Carbazoles; Carvedilol; Drug Interactions; Enalapril; Humans; Hypotension; Lidocaine; Male; Middle Aged; Propanolamines; Vasoconstrictor Agents | 2014 |
Idiopathic ventricular fibrillation associated with early repolarization which was unmasked by a sodium channel blocker after catheter ablation of atrial fibrillation.
Topics: Atrial Fibrillation; Catheter Ablation; Electrocardiography; Female; Follow-Up Studies; Humans; Injections, Intravenous; Isoproterenol; Lidocaine; Middle Aged; Risk Assessment; Sodium Channel Blockers; Treatment Outcome; Ventricular Fibrillation | 2014 |
Quantitation of pilsicainide in microscale samples of human biological fluids using liquid chromatography-tandem mass spectrometry.
Topics: Adult; Chromatography, Liquid; Drug Monitoring; Humans; Lidocaine; Linear Models; Male; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Young Adult | 2015 |
Significance of electrocardiogram recording in high intercostal spaces in patients with early repolarization syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Humans; Lidocaine; Male; Prognosis; Recurrence; Risk Assessment; Ventricular Fibrillation | 2016 |
Right coronary cusp as a new window of ablation for pilsicainide-induced ventricular premature contractions in a patient with Brugada syndrome.
Topics: Adult; Brugada Syndrome; Electrocardiography; Electrophysiologic Techniques, Cardiac; Heart Ventricles; Humans; Lidocaine; Male; Pericardium; Sodium Channel Blockers; Ventricular Premature Complexes | 2016 |
A Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECG.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Base Sequence; Brugada Syndrome; DNA Mutational Analysis; Electrocardiography; HEK293 Cells; Humans; Lidocaine; Male; Mutation, Missense; NAV1.5 Voltage-Gated Sodium Channel | 2016 |
Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiovascular Physiological Phenomena; Electrocardiography; Heart; Heart Rate; Infusions, Intravenous; Lidocaine; Piperidines; Pyridines; Swine; Swine, Miniature; Verapamil | 2017 |
Utility of 12-lead and signal-averaged Holter electrocardiograms after pilsicainide provocation for risk stratification in Brugada syndrome.
Topics: Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography, Ambulatory; Female; Humans; Lidocaine; Male; Middle Aged; Retrospective Studies; Risk Assessment; Risk Factors; ROC Curve; Ventricular Fibrillation | 2017 |
Inhibitory effects of local anesthetics on the proteasome and their biological actions.
Topics: Anesthetics, Local; Animals; Cattle; Cell Line, Tumor; Cell Proliferation; Humans; Leupeptins; Lidocaine; Molecular Docking Simulation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability | 2017 |
Prognostic Significance of the Sodium Channel Blocker Test in Patients With Brugada Syndrome.
Topics: Administration, Intravenous; Adult; Aged; Brugada Syndrome; Death, Sudden, Cardiac; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Predictive Value of Tests; Progression-Free Survival; Risk Assessment; Risk Factors; Sodium Channel Blockers; Tachycardia, Ventricular; Time Factors; Ventricular Fibrillation | 2018 |
Successful treatment for various arrhythmias in an older patient treated with pilsicainide for paroxysmal supraventricular tachycardia.
Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Electrocardiography; Female; Humans; Lidocaine; Tachycardia, Paroxysmal; Tachycardia, Supraventricular | 2018 |
Clinical and Electrocardiographic Differences in Brugada Syndrome With Spontaneous or Drug-Induced Type 1 Electrocardiogram.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Prognosis; Ventricular Fibrillation | 2019 |
Pilsicainide Administration Unmasks a Phenotype of Brugada Syndrome in a Patient with Overlap Syndrome due to the E1784K SCN5A Mutation.
Topics: Adult; Anti-Arrhythmia Agents; Brugada Syndrome; Electrocardiography; Humans; Lidocaine; Long QT Syndrome; Male; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Phenotype; Ventricular Fibrillation | 2020 |
Involvement of the persistent Na
Topics: Action Potentials; Animals; Atrial Fibrillation; Cells, Cultured; Diastole; Guinea Pigs; Lidocaine; Male; Membrane Potentials; Myocytes, Cardiac; Pulmonary Veins; Pyridines; Sodium; Tetrodotoxin; Triazoles | 2019 |
Development of Pulmonary Edema Despite Negative Fluid Balance with Diuretics in a Patient with Heart Failure and Sigmoid Septum.
Topics: Aged, 80 and over; Diuretics; Furosemide; Heart Failure; Humans; Lidocaine; Male; Pulmonary Edema; Ventricular Outflow Obstruction; Ventricular Septum | 2020 |
Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Heart; Heart Rate; Lidocaine; Male; Myocardial Contraction; Phenylurea Compounds; Pinacidil; Rabbits; Sodium Channel Blockers; Tachycardia, Ventricular; Tetrazoles | 2020 |
Efficacy of a Subcutaneous Implantable Cardioverter Defibrillator in a Child with Early Repolarization Syndrome.
Topics: Anti-Arrhythmia Agents; Child; Death, Sudden, Cardiac; Defibrillators, Implantable; Electrocardiography; Humans; Lidocaine; Male; Ventricular Fibrillation | 2021 |
Pilsicainide intoxication mimicking hyperkalemia effectively managed by prompt diagnosis and emergency haemodialysis.
Topics: Anti-Arrhythmia Agents; Humans; Hyperkalemia; Lidocaine; Poisoning; Renal Dialysis | 2022 |
Negative Inotropic Effects of Class I Antiarrhythmics on Guinea Pig Ventricular Myocardium: Correlation with L-Type Ca
Topics: Animals; Anti-Arrhythmia Agents; Guinea Pigs; Lidocaine; Myocardium; Papillary Muscles; Propafenone | 2023 |
Cardiac Arrest Due to Pacing Failure From Pilsicainide Poisoning.
Topics: Anti-Arrhythmia Agents; Heart Arrest; Humans; Lidocaine | 2023 |