lidocaine and nifedipine

lidocaine has been researched along with nifedipine in 85 studies

Research

Studies (85)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (16.47)	18.7374
1990's	16 (18.82)	18.2507
2000's	33 (38.82)	29.6817
2010's	22 (25.88)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Dubinsky, B; Moore, JB; Press, JB; Sanfilippo, PJ; Urbanski, M	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Barecki, M; Casciano, CN; Clement, RP; Johnson, WW; Lew, K; Wang, E	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Sen, S; Sinha, N	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Brouillette, WJ; Brown, GB; Zha, C	1
Bennis, K; Ducki, S; Lesage, F; Vivier, D	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Basiez, M; Labrid, C; Leinot, M; Talvard, J	1
Narimatsu, A; Taira, N	1
Hanano, M; Iga, T; Okudaira, K; Sawada, Y; Sugiyama, Y; Yamazaki, M	1
Funae, Y; Imai, Y; Imaoka, S; Shimada, T	1
Hunt, CM; Stave, GM; Westerkam, WR	1
Chmel-Dunaj, GN; Jurevicius, J; Macianskiene, R; Muckus, K	1
Nebel, U; Wermelskirchen, D; Wilffert, B; Wirth, A	1
Cheng, YZ; Liu, TF; Wang, ZM	1
Schwartz, PJ; Vanoli, E	1
Humphreys, T; Lathrop, DA; Murphy, AM; Schwartz, A	1
Bentwich, Z; Bibi, H; Eliraz, A; Fink, A; Tabachnik, E	1
Appleby, DH; Van Lith, RM	1
Parratt, JR	1
Beinart, C; Saddekni, S; Sniderman, KW; Sos, TA; Weiner, MA	1
Hay, DW; Wadsworth, RM	1
Hess, DS; Scheinman, MM	1
Alps, BJ; Calder, C; Wilson, A	1
Bergey, JL; McCallum, JD; Nocella, K	1
Ginkawa, M; Kontani, H; Sakai, T	1
Watkins, PB	1
Hoener, BA	1
Bainton, CR; Strichartz, GR	1
Klangwarnwong, D; Manorot, M; Praisontarangkul, OA; Tonsuwannont, W	1
Ito, KI; Kato, H; Miura, M; Miyakawa, H; Yoshioka, M	1
Ferrier, GR; Howlett, SE; Zhu, JQ	1
Jaup, EA; Jodal, M; Lundgren, O; Timar Peregrin, A	1
Alger, BE; Lenz, RA; Wagner, JJ	1
Berlioz, F; Carbon, C; Chariot, J; Farinotti, R; Julien, S; Rozé, C; Tsocas, A	1
Freitas-da-Fonseca, A; Mårdh, PA; Martinez-de-Oliveira, J; Pina-Vaz, C; Rodrigues, AA	1
Antropoli, C; Antropoli, M; De Stefano, G; Molino, D; Perrotti, P	1
Farrugia, G; Gibbons, S; Holm, AN; Miller, SM; Ou, Y; Rae, JL; Rich, A; Sarr, MG; Strege, P; Szurszewski, JH	1
Antropoli, C; Antropoli, M; Attena, F; Balzano, A; Bove, A; De Stefano, G; Molino, D; Perrotti, P	1
Merenstein, D; Rosenbaum, D	1
Camara, AK; Chen, Q; Rhodes, SS; Riess, ML; Ropella, KM; Stowe, DF	1
Jankovic, SM; Jankovic, SV; Protic, BA	2
Camara, AK; Chen, Q; Rhodes, SS; Riess, ML; Stowe, DF	1
Hiroshi, N; Katoh, H; Okada, Y; Sakamoto, T; Shima, K; Tuzuki, N; Yanagawa, Y	1
Antropoli, C; Barbato, F; Grumetto, L; Perrotti, P	1
Comer, GR; Franchini, JL; Propst, JT; Yost, MJ	1
Kitano, H; Shinohara, H; Zakir Hossain, SM	1
Kaman, L; Medhi, B; Pandhi, P; Prakash, A; Prakash, O; Rao, RS	1
Cheng, Y; Efimov, IR; Mowrey, KA	1
Ando, H; Araki, N; Enosawa, S; Fujimura, A; Hasegawa, G; Nagai, H; Omasa, T; Tsuruoka, S; Wang, N; Yanagihara, H	1
Cantiello, F; Di Meo, S; Fusco, F; Iannuzzo, M; Imbimbo, C; Imperatore, V; Mirone, V; Scibelli, G	1
Antropoli, C; Cerutti, R; Cusato, M; Dominici, P; Giannotti, G; Grossi, E; Perrotti, P; Regazzi, M	1
Antropoli, C; Cerutti, R; Dominici, P; Grossi, E; Perrotti, P	1
Aoki, M; Haga, M; Hayashi, M; Nishigaki, R; Okudaira, K	1
Alaei, S; Baharvand, H; Gourabi, H; Hatami, M; Hemmesi, K; Kiani, S; Masoudi, N; Nemati, S	1
Cupić, V; Gojković-Bukarica, L; Heinle, H; Ivković, B; Novaković, R; Vladimirov, S	1
Nilsson, MF; Ritchie, H; Webster, WS	1
Dosen, PJ; Imtiaz, MS; Isbister, GK; Laver, DR; Thomas, PA; van Helden, DF	1
Abu-Kishk, I; Berkovitch, M; Efrati, Y; Klin, B	1
Grigoriev, A; Nikitina, A; Sidorova, A; Yaroshenko, I	1
Karavana, SY; Önder, T; Rençber, S; Sarıışık, AM; Türkoğlu, GC	1
Abdelghani, GM; Elghadban, HM; Mohamed, EA; Salem, AE	1

Reviews

5 review(s) available for lidocaine and nifedipine

Article	Year
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11 Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship	2016
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
New antiarrhythmic drugs. American journal of surgery, 1983, Volume: 145, Issue:6 Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half-Life; Humans; Hypertension; Lidocaine; Metoprolol; Nadolol; Nifedipine; Propanolamines; Propranolol; Tocainide; Verapamil	1983
Noninvasive tests of CYP3A enzymes. Pharmacogenetics, 1994, Volume: 4, Issue:4 Topics: Animals; Breath Tests; Cytochrome P-450 Enzyme System; Dapsone; Erythromycin; Humans; Hydrocortisone; Lidocaine; Liver; Midazolam; Nifedipine	1994
Recent advances in the pharmacotherapy of chronic anal fissure: an update. Asian journal of surgery, 2008, Volume: 31, Issue:3 Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Diltiazem; Fissure in Ano; Headache; Humans; Indoramin; Injections, Intralesional; Lidocaine; Nifedipine; Nitroglycerin; Ointments	2008

Trials

8 trial(s) available for lidocaine and nifedipine

Article	Year
Pharmacokinetics of oral lidocaine and nifedipine in patients with liver cirrhosis. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1996, Volume: 79, Issue:5 Topics: Administration, Oral; Adult; Anesthetics; Cross-Over Studies; Female; Hemodynamics; Humans; Lidocaine; Liver; Liver Cirrhosis; Male; Middle Aged; Nifedipine; Sensitivity and Specificity; Severity of Illness Index; Vasodilator Agents	1996
Conservative treatment of acute thrombosed external hemorrhoids with topical nifedipine. Diseases of the colon and rectum, 2001, Volume: 44, Issue:3 Topics: Acute Disease; Administration, Topical; Adult; Female; Hemorrhoids; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Pain Measurement; Prospective Studies; Thrombosis; Treatment Outcome	2001
Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study. Diseases of the colon and rectum, 2002, Volume: 45, Issue:11 Topics: Administration, Topical; Adolescent; Adult; Aged; Chronic Disease; Double-Blind Method; Drug Combinations; Female; Fissure in Ano; Humans; Hydrocortisone; Lidocaine; Male; Manometry; Middle Aged; Nifedipine; Prospective Studies; Recurrence; Treatment Outcome	2002
Serum levels and possible haemodynamic effects following anorectal application of an ointment containing nifedipine and lignocaine : a study in healthy volunteers. Clinical drug investigation, 2006, Volume: 26, Issue:8 Topics: Administration, Topical; Adult; Anal Canal; Anesthetics, Local; Blood Pressure; Chromatography, High Pressure Liquid; Electrocardiography; Female; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Ointments	2006
Periprostatic nerve block (PNB) alone vs PNB combined with an anaesthetic-myorelaxant agent cream for prostate biopsy: a prospective, randomized double-arm study. BJU international, 2009, Volume: 103, Issue:9 Topics: Aged; Anesthetics, Local; Biopsy, Needle; Drug Therapy, Combination; Epidemiologic Methods; Humans; Lidocaine; Male; Middle Aged; Nerve Block; Neuromuscular Depolarizing Agents; Nifedipine; Pain; Pain Measurement; Prostatic Neoplasms; Treatment Outcome; Ultrasonography, Interventional	2009
Pharmacokinetics of anorectal nifedipine and lidocaine (lignocaine) ointment following haemorrhoidectomy: an open-label, single-dose, phase IV clinical study. Clinical drug investigation, 2009, Volume: 29, Issue:4 Topics: Administration, Topical; Adult; Aged; Anal Canal; Anesthetics, Local; Area Under Curve; Blood Pressure; Chromatography, High Pressure Liquid; Drug Combinations; Electrocardiography; Female; Heart Rate; Hemorrhoids; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Ointments; Vasodilator Agents	2009
Topical nifedipine with lidocaine ointment versus active control for pain after hemorrhoidectomy: results of a multicentre, prospective, randomized, double-blind study. Canadian journal of surgery. Journal canadien de chirurgie, 2010, Volume: 53, Issue:1 Topics: Adult; Anesthetics, Local; Calcium Channel Blockers; Double-Blind Method; Drug Combinations; Female; Hemorrhoids; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Ointments; Pain, Postoperative; Prospective Studies	2010
Potential combination topical therapy of anal fissure: development, evaluation, and clinical study†. Drug delivery, 2018, Volume: 25, Issue:1 Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Drug Combinations; Drug Compounding; Drug Therapy, Combination; Excipients; Female; Fissure in Ano; Gels; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Prospective Studies; Vasodilator Agents; Young Adult	2018

Other Studies

72 other study(ies) available for lidocaine and nifedipine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity. Journal of medicinal chemistry, 1988, Volume: 31, Issue:11 Topics: Amines; Anesthetics, Local; Animals; Calcium Channel Blockers; Drug Evaluation, Preclinical; Heterocyclic Compounds; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Rabbits; Trachea	1988
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chemical research in toxicology, 2001, Volume: 14, Issue:12 Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Mice; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Substrate Specificity	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands. Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1 Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels	2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
[Prolongation of the effective refractory period on isolated guinea pig atria by some anti-arrhythmia agents: relevance in a comparison of their potentialities]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1979, Volume: 173, Issue:4 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Lidocaine; Myocardial Contraction; Nifedipine; Verapamil	1979
Effects of atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog. Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 294, Issue:2 Topics: Action Potentials; Anesthetics, Local; Animals; Atrioventricular Node; Benzazepines; Calcium; Coronary Circulation; Coronary Vessels; Diltiazem; Dogs; Female; Heart Conduction System; In Vitro Techniques; Injections; Lidocaine; Male; Neural Conduction; Nifedipine; Procaine; Quinidine; Vasodilator Agents; Verapamil	1976
Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes. Pharmaceutical research, 1992, Volume: 9, Issue:9 Topics: Animals; Chlorpromazine; Dipyridamole; Disopyramide; Drug Interactions; In Vitro Techniques; Lidocaine; Liver; Male; Nifedipine; Ouabain; Propranolol; Quinidine; Rats; Rats, Wistar; Sodium; Taurocholic Acid; Verapamil	1992
Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity. Biochemistry, 1992, Jul-07, Volume: 31, Issue:26 Topics: Animals; Benzene Derivatives; Benzoflavones; Catalysis; Cholic Acid; Cholic Acids; Cytochrome P-450 Enzyme System; Enzyme Activation; Humans; Lidocaine; NADPH-Ferrihemoprotein Reductase; Nifedipine; Oxidation-Reduction; Phosphatidylcholines; Phosphatidylserines; Phospholipids; Rabbits; Rats; Testosterone	1992
Effect of age and gender on the activity of human hepatic CYP3A. Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Humans; Lidocaine; Microsomes, Liver; Middle Aged; Nifedipine; Oxidoreductases, N-Demethylating; Quinidine; Sex Factors; Smoking	1992
Influence of action potential duration and resting potential on effects of quinidine, lidocaine and ethmozin on Vmax in guinea-pig papillary muscles. Journal of molecular and cellular cardiology, 1991, Volume: 23 Suppl 1 Topics: Action Potentials; Animals; Female; Guinea Pigs; Lidocaine; Male; Membrane Potentials; Moricizine; Nifedipine; Papillary Muscles; Potassium; Quinidine; Time Factors	1991
45Ca2+ movements induced by Ca2+ chloride in isolated rat aorta under K(+)-free conditions. European journal of pharmacology, 1991, Jan-17, Volume: 192, Issue:3 Topics: Amiloride; Animals; Aorta, Thoracic; Benzothiazoles; Calcium; Calcium Chloride; Calcium Radioisotopes; Flunarizine; In Vitro Techniques; Indomethacin; Lanthanum; Lidocaine; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Piperidines; Potassium; Rats; Thiazoles; Vasoconstriction	1991
Early afterdepolarization induced by ryanodine in atrial fibers of mouse heart. Methods and findings in experimental and clinical pharmacology, 1990, Volume: 12, Issue:8 Topics: Action Potentials; Animals; Female; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Male; Mice; Nifedipine; Ryanodine; Tetrodotoxin	1990
An experimental approach to the choice of antiarrhythmic therapy. European heart journal, 1986, Volume: 7 Suppl A Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil	1986
Effects of bepridil on force development and transmembrane electrical activity of adult canine Purkinje strands: comparison with nisoldipine and lidocaine. European journal of pharmacology, 1985, Dec-03, Volume: 118, Issue:3 Topics: Animals; Bepridil; Calcium Channel Blockers; Dogs; Female; Heart Conduction System; Lidocaine; Male; Membrane Potentials; Nifedipine; Nisoldipine; Purkinje Fibers; Pyrrolidines; Time Factors	1985
Leukotrienes (LTC4, LTD4) confer glass non-adherence on leukocytes of asthmatic individuals. Dependency on cyclooxygenase products and calcium ion. Immunology letters, 1985, Volume: 10, Issue:6 Topics: Asthma; Calcium; Cell Adhesion; Child; Cyclooxygenase Inhibitors; Dinoprostone; Glass; Humans; Indomethacin; Lanthanum; Leukocyte Adherence Inhibition Test; Leukocytes; Lidocaine; Nifedipine; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; SRS-A; Trifluoperazine	1985
Quinidine-nifedipine interaction. Drug intelligence & clinical pharmacy, 1985, Volume: 19, Issue:11 Topics: Aged; Biological Availability; Drug Interactions; Humans; Lidocaine; Male; Myocardial Infarction; Nifedipine; Quinidine	1985
Pharmacological agents to aid the clinician in combating myocardial ischaemia. European heart journal, 1983, Volume: 4 Suppl D Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Coronary Disease; Dogs; Humans; Ion Channels; Lidocaine; Male; Myocardial Infarction; Myocardium; Nifedipine; Nitroglycerin; Rats; Sodium	1983
Arterial spasm during renal angioplasty. Radiology, 1983, Volume: 149, Issue:1 Topics: Adolescent; Adult; Aged; Angioplasty, Balloon; Arterial Occlusive Diseases; Arteriosclerosis; Child; Female; Fibromuscular Dysplasia; Heparin; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Nitroglycerin; Premedication; Renal Artery; Spasm; Tolazoline; Verapamil	1983
The effects of calcium channel inhibitors on twitches and noradrenaline contractions of the rat bisected vas deferens. European journal of pharmacology, 1983, Mar-04, Volume: 87, Issue:4 Topics: Animals; Calcium Channel Blockers; In Vitro Techniques; Ion Channels; Lidocaine; Male; Muscle Contraction; Nifedipine; Nitroprusside; Norepinephrine; Rats; Vas Deferens; Verapamil	1983
The beneficial effect of nicardipine compared with nifedipine and verapamil in limiting myocardial infarct size in baboons. Arzneimittel-Forschung, 1983, Volume: 33, Issue:6 Topics: Animals; Calcium Channel Blockers; Female; Hemodynamics; Lidocaine; Male; Myocardial Infarction; Nicardipine; Nifedipine; Nitroblue Tetrazolium; Papio; Pyridines; Verapamil	1983
Antiarrhythmic evaluation of verapamil, nifedipine, perhexiline and skf 525-A in four canine models of cardiac arrhythmias. European journal of pharmacology, 1981, Mar-26, Volume: 70, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Calcium; Dogs; Female; Heart Rate; Lidocaine; Male; Myocardial Contraction; Nifedipine; Perhexiline; Piperidines; Proadifen; Pyridines; Verapamil	1981
A simple method for measurement of ureteric peristaltic function in vivo and the effects of drugs acting on ion channels applied from the ureter lumen in anesthetized rats. Japanese journal of pharmacology, 1993, Volume: 62, Issue:4 Topics: 4-Aminopyridine; Anesthesia; Animals; Benzopyrans; Cromakalim; Glyburide; Ion Channels; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Rats; Rats, Sprague-Dawley; Ureter; Vasodilator Agents	1993
Predicting the hepatic clearance of xenobiotics in humans from in vitro data. Biopharmaceutics & drug disposition, 1994, Volume: 15, Issue:4 Topics: Biological Availability; Chlorzoxazone; Cytochrome P-450 Enzyme System; Humans; Hydrocortisone; Lidocaine; Liver; Mathematics; Metabolic Clearance Rate; Mexiletine; Nifedipine; Predictive Value of Tests; Rifampin; Xenobiotics	1994
Concentration dependence of lidocaine-induced irreversible conduction loss in frog nerve. Anesthesiology, 1994, Volume: 81, Issue:3 Topics: Action Potentials; Animals; Calcium Channels; Drug Interactions; In Vitro Techniques; Kinetics; Lidocaine; Nerve Block; Neural Conduction; Nifedipine; Peripheral Nervous System Diseases; Rana catesbeiana; Sciatic Nerve; Sensitivity and Specificity	1994
Properties of calcium spikes revealed during GABAA receptor antagonism in hippocampal CA1 neurons from guinea pigs. Journal of neurophysiology, 1997, Volume: 78, Issue:5 Topics: Animals; Bicuculline; Cadmium; Calcium; Calcium Channel Blockers; Electric Stimulation; Electrophysiology; Evoked Potentials; GABA-A Receptor Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Nifedipine; omega-Agatoxin IVA; Picrotoxin; Pyramidal Cells; Sodium Channel Blockers; Spider Venoms; Tetrodotoxin; Virulence Factors, Bordetella	1997
Contribution of a voltage-sensitive calcium release mechanism to contraction in cardiac ventricular myocytes. The American journal of physiology, 1998, Volume: 274, Issue:1 Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Guinea Pigs; Heart Ventricles; Lidocaine; Male; Membrane Potentials; Myocardial Contraction; Nifedipine; Ryanodine; Sodium Channel Blockers; Thapsigargin; Time Factors; Verapamil	1998
Nervous control of alkaline secretion in the duodenum as studied by the use of cholera toxin in the anaesthetized rat. Acta physiologica Scandinavica, 1998, Volume: 162, Issue:2 Topics: Alkalies; Anesthesia; Anesthetics, Local; Animals; Atropine; Calcium Channel Blockers; Cholera Toxin; Duodenum; Granisetron; Hexamethonium; Lidocaine; Male; Muscarinic Antagonists; Myenteric Plexus; Nicotinic Antagonists; Nifedipine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists	1998
N- and L-type calcium channel involvement in depolarization-induced suppression of inhibition in rat hippocampal CA1 cells. The Journal of physiology, 1998, Oct-01, Volume: 512 ( Pt 1) Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Lidocaine; Male; Nickel; Nifedipine; omega-Conotoxin GVIA; Peptides; Pyramidal Cells; Rats; Rats, Sprague-Dawley	1998
Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3 Topics: Adrenergic Antagonists; Animals; ATP-Binding Cassette Transporters; Bacterial Proteins; Cephalexin; Cephalosporins; Hexamethonium; Intestinal Absorption; Jejunum; Lidocaine; Male; Membrane Transport Proteins; Microvilli; Nifedipine; Prazosin; Rats; Rats, Wistar; Yohimbine	1999
Inhibition of germ tube formation by Candida albicans by local anesthetics: an effect related to ionic channel blockade. Current microbiology, 2000, Volume: 40, Issue:3 Topics: Amides; Anesthetics, Local; Calcium; Candida albicans; Dose-Response Relationship, Drug; Ion Channels; Lanthanum; Lidocaine; Nifedipine; Ropivacaine; Verapamil	2000
Sodium current in human jejunal circular smooth muscle cells. Gastroenterology, 2002, Volume: 122, Issue:1 Topics: Anesthetics, Local; Calcium Channel Blockers; Calcium Channels, L-Type; Humans; Jejunum; Kinetics; Lidocaine; Membrane Potentials; Molecular Sequence Data; Muscle, Smooth; NAV1.5 Voltage-Gated Sodium Channel; Nifedipine; Patch-Clamp Techniques; RNA, Messenger; Sequence Homology, Amino Acid; Sodium; Sodium Channels; Tetrodotoxin	2002
Is topical nifedipine effective for chronic anal fissures? The Journal of family practice, 2003, Volume: 52, Issue:3 Topics: Administration, Topical; Anesthetics, Local; Chronic Disease; Double-Blind Method; Evidence-Based Medicine; Fissure in Ano; Humans; Lidocaine; Nifedipine; Ointments; Pain Measurement; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome; Vasodilator Agents; Wound Healing	2003
How inotropic drugs alter dynamic and static indices of cyclic myoplasmic [Ca2+] to contractility relationships in intact hearts. Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:4 Topics: Animals; Calcium; Digoxin; Dopamine; Guinea Pigs; Lidocaine; Muscle Contraction; Myocardial Contraction; Myocardium; Nifedipine; Signal Processing, Computer-Assisted; Ventricular Function; Ventricular Function, Left; Ventricular Pressure	2003
Contractile effect of acetylcholine on isolated ampullar segment of Fallopian tubes. Pharmacological research, 2004, Volume: 49, Issue:1 Topics: Acetylcholine; Adult; Aged; Diamines; Fallopian Tubes; Female; Follicular Phase; Humans; Lidocaine; Luteal Phase; Mecamylamine; Menopause; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Piperidines; Pirenzepine; Verapamil	2004
Negative inotropic drugs alter indexes of cytosolic [Ca(2+)]-left ventricular pressure relationships after ischemia. American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:2 Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cytosol; Diacetyl; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Lidocaine; Myocardial Ischemia; Myocardial Reperfusion Injury; Nifedipine; Osmolar Concentration; Pressure; Ventricular Function, Left	2004
Contractile effect of acetylcholine on isolated isthmic segment of fallopian tubes. Methods and findings in experimental and clinical pharmacology, 2004, Volume: 26, Issue:2 Topics: Acetylcholine; Adult; Aged; Atropine; Diamines; Dose-Response Relationship, Drug; Fallopian Tubes; Female; Follicular Phase; Humans; Lidocaine; Luteal Phase; Mecamylamine; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Piperidines; Pirenzepine; Postmenopause; Receptors, Muscarinic	2004
Intubation without premedication may worsen outcome for unconsciousness patients with intracranial hemorrhage. The American journal of emergency medicine, 2005, Volume: 23, Issue:2 Topics: Analgesics, Opioid; Anesthetics, Local; Anti-Anxiety Agents; Diazepam; Emergency Medicine; Female; Fentanyl; Glasgow Outcome Scale; Humans; Intracranial Hemorrhages; Intubation, Intratracheal; Lidocaine; Male; Middle Aged; Nicardipine; Nifedipine; Outcome and Process Assessment, Health Care; Pentazocine; Premedication; Retrospective Studies; Unconsciousness; Vasodilator Agents	2005
Novel tissue engineered tubular heart tissue for in vitro pharmaceutical toxicity testing. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2007, Volume: 13, Issue:4 Topics: Animal Testing Alternatives; Animals; Apoptosis; Caspase 3; Collagen; Isoproterenol; Lidocaine; Microscopy, Confocal; Myocytes, Cardiac; Nifedipine; Rats; Tissue Engineering; Toxicity Tests; Xenobiotics	2007
Drug assessment based on detection of L-glutamate released from C6 glioma cells using an enzyme-luminescence method. Analytical chemistry, 2008, May-15, Volume: 80, Issue:10 Topics: 4-Aminopyridine; Animals; Brain Neoplasms; Carbamazepine; Cell Line, Tumor; Enzymes; Flunarizine; Glioma; Glutamic Acid; Lidocaine; Luminescence; Nickel; Nifedipine; Rats; Veratridine	2008
Membrane time constant during internal defibrillation strength shocks in intact heart: effects of Na+ and Ca2+ channel blockers. Journal of cardiovascular electrophysiology, 2009, Volume: 20, Issue:1 Topics: Animals; Calcium Channel Blockers; Cell Membrane; Computer Simulation; Dose-Response Relationship, Drug; Electric Countershock; In Vitro Techniques; Kinetics; Lidocaine; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Nifedipine; Rabbits; Sodium Channel Blockers	2009
Human CYP3A4-introduced HepG2 cells: in vitro screening system of new chemicals for the evaluation of CYP3A4-inhibiting activity. Xenobiotica; the fate of foreign compounds in biological systems, 2008, Volume: 38, Issue:11 Topics: Ammonia; Animals; Atorvastatin; Cell Line, Tumor; Cricetinae; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Heptanoic Acids; Humans; Ketoconazole; Lidocaine; Nifedipine; Pyrroles	2008
Contribution of rat pulmonary metabolism to the elimination of lidocaine, midazolam, and nifedipine. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:7 Topics: Animals; Drug Administration Routes; Drug Evaluation, Preclinical; Forecasting; In Vitro Techniques; Lidocaine; Lung; Male; Microsomes; Microsomes, Liver; Midazolam; Nifedipine; Rats; Rats, Wistar	2010
Long-term self-renewable feeder-free human induced pluripotent stem cell-derived neural progenitors. Stem cells and development, 2011, Volume: 20, Issue:3 Topics: Antigens, Differentiation; Calcium Channel Blockers; Cell Culture Techniques; Cell Differentiation; Cell Line; Cell Shape; Cryopreservation; Gene Expression Profiling; Humans; Induced Pluripotent Stem Cells; Intermediate Filament Proteins; Lidocaine; Membrane Potentials; Nerve Tissue Proteins; Nestin; Neural Stem Cells; Neurons; Nifedipine; Potassium Channel Blockers; SOXB1 Transcription Factors; Tetraethylammonium; Transcription, Genetic	2011
The novel phenylpropiophenone derivates induced relaxation of isolated rat aorta. Arzneimittel-Forschung, 2012, Volume: 62, Issue:7 Topics: Animals; Aorta; In Vitro Techniques; Lidocaine; Male; Nifedipine; Phenylephrine; Propafenone; Propiophenones; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilation	2012
The effect on rat embryonic heart rate of Na+, K+, and Ca2+ channel blockers, and the human teratogen phenytoin, changes with gestational age. Birth defects research. Part B, Developmental and reproductive toxicology, 2013, Volume: 98, Issue:5 Topics: Animals; Calcium Channel Blockers; Female; Gestational Age; Heart Rate, Fetal; Lidocaine; Nifedipine; Phenethylamines; Phenytoin; Potassium Channel Blockers; Pregnancy; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sulfonamides	2013
Pharmacological approaches that slow lymphatic flow as a snakebite first aid. PLoS neglected tropical diseases, 2014, Volume: 8, Issue:2 Topics: Animals; Elapid Venoms; Female; First Aid; Humans; Lidocaine; Lymphatic System; Male; Nifedipine; Rats; Respiration; Snake Bites	2014
Anal fissure in children: a 10-year clinical experience with nifedipine gel with lidocaine. Minerva pediatrica, 2016, Volume: 68, Issue:3 Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Child, Preschool; Drug Combinations; Female; Fissure in Ano; Humans; Infant; Lidocaine; Male; Nifedipine; Recurrence; Retrospective Studies; Treatment Outcome; Vasodilator Agents; Wound Healing	2016
Development of a HPLC-MS/MS method for the simultaneous determination of nifedipine and lidocaine in human plasma. Journal of pharmaceutical and biomedical analysis, 2016, Nov-30, Volume: 131 Topics: Chromatography, High Pressure Liquid; Humans; Lidocaine; Nifedipine; Reproducibility of Results; Tandem Mass Spectrometry	2016
Preparation and characterization of textile-based carrier systems for anal fissure treatment. Journal of microencapsulation, 2017, Volume: 34, Issue:8 Topics: Alginates; Anesthetics, Local; Drug Carriers; Drug Delivery Systems; Drug Liberation; Fissure in Ano; Glucuronic Acid; Hexuronic Acids; Humans; Lidocaine; Nifedipine; Tampons, Surgical; Textiles; Vasodilator Agents	2017