lidocaine has been researched along with nifedipine in 85 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 14 (16.47) | 18.7374 |
1990's | 16 (18.82) | 18.2507 |
2000's | 33 (38.82) | 29.6817 |
2010's | 22 (25.88) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
Dubinsky, B; Moore, JB; Press, JB; Sanfilippo, PJ; Urbanski, M | 1 |
Duffy, EM; Jorgensen, WL | 1 |
Topliss, JG; Yoshida, F | 1 |
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
Barecki, M; Casciano, CN; Clement, RP; Johnson, WW; Lew, K; Wang, E | 1 |
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Sen, S; Sinha, N | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Brouillette, WJ; Brown, GB; Zha, C | 1 |
Bennis, K; Ducki, S; Lesage, F; Vivier, D | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
Basiez, M; Labrid, C; Leinot, M; Talvard, J | 1 |
Narimatsu, A; Taira, N | 1 |
Hanano, M; Iga, T; Okudaira, K; Sawada, Y; Sugiyama, Y; Yamazaki, M | 1 |
Funae, Y; Imai, Y; Imaoka, S; Shimada, T | 1 |
Hunt, CM; Stave, GM; Westerkam, WR | 1 |
Chmel-Dunaj, GN; Jurevicius, J; Macianskiene, R; Muckus, K | 1 |
Nebel, U; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
Cheng, YZ; Liu, TF; Wang, ZM | 1 |
Schwartz, PJ; Vanoli, E | 1 |
Humphreys, T; Lathrop, DA; Murphy, AM; Schwartz, A | 1 |
Bentwich, Z; Bibi, H; Eliraz, A; Fink, A; Tabachnik, E | 1 |
Appleby, DH; Van Lith, RM | 1 |
Parratt, JR | 1 |
Beinart, C; Saddekni, S; Sniderman, KW; Sos, TA; Weiner, MA | 1 |
Hay, DW; Wadsworth, RM | 1 |
Hess, DS; Scheinman, MM | 1 |
Alps, BJ; Calder, C; Wilson, A | 1 |
Bergey, JL; McCallum, JD; Nocella, K | 1 |
Ginkawa, M; Kontani, H; Sakai, T | 1 |
Watkins, PB | 1 |
Hoener, BA | 1 |
Bainton, CR; Strichartz, GR | 1 |
Klangwarnwong, D; Manorot, M; Praisontarangkul, OA; Tonsuwannont, W | 1 |
Ito, KI; Kato, H; Miura, M; Miyakawa, H; Yoshioka, M | 1 |
Ferrier, GR; Howlett, SE; Zhu, JQ | 1 |
Jaup, EA; Jodal, M; Lundgren, O; Timar Peregrin, A | 1 |
Alger, BE; Lenz, RA; Wagner, JJ | 1 |
Berlioz, F; Carbon, C; Chariot, J; Farinotti, R; Julien, S; Rozé, C; Tsocas, A | 1 |
Freitas-da-Fonseca, A; Mårdh, PA; Martinez-de-Oliveira, J; Pina-Vaz, C; Rodrigues, AA | 1 |
Antropoli, C; Antropoli, M; De Stefano, G; Molino, D; Perrotti, P | 1 |
Farrugia, G; Gibbons, S; Holm, AN; Miller, SM; Ou, Y; Rae, JL; Rich, A; Sarr, MG; Strege, P; Szurszewski, JH | 1 |
Antropoli, C; Antropoli, M; Attena, F; Balzano, A; Bove, A; De Stefano, G; Molino, D; Perrotti, P | 1 |
Merenstein, D; Rosenbaum, D | 1 |
Camara, AK; Chen, Q; Rhodes, SS; Riess, ML; Ropella, KM; Stowe, DF | 1 |
Jankovic, SM; Jankovic, SV; Protic, BA | 2 |
Camara, AK; Chen, Q; Rhodes, SS; Riess, ML; Stowe, DF | 1 |
Hiroshi, N; Katoh, H; Okada, Y; Sakamoto, T; Shima, K; Tuzuki, N; Yanagawa, Y | 1 |
Antropoli, C; Barbato, F; Grumetto, L; Perrotti, P | 1 |
Comer, GR; Franchini, JL; Propst, JT; Yost, MJ | 1 |
Kitano, H; Shinohara, H; Zakir Hossain, SM | 1 |
Kaman, L; Medhi, B; Pandhi, P; Prakash, A; Prakash, O; Rao, RS | 1 |
Cheng, Y; Efimov, IR; Mowrey, KA | 1 |
Ando, H; Araki, N; Enosawa, S; Fujimura, A; Hasegawa, G; Nagai, H; Omasa, T; Tsuruoka, S; Wang, N; Yanagihara, H | 1 |
Cantiello, F; Di Meo, S; Fusco, F; Iannuzzo, M; Imbimbo, C; Imperatore, V; Mirone, V; Scibelli, G | 1 |
Antropoli, C; Cerutti, R; Cusato, M; Dominici, P; Giannotti, G; Grossi, E; Perrotti, P; Regazzi, M | 1 |
Antropoli, C; Cerutti, R; Dominici, P; Grossi, E; Perrotti, P | 1 |
Aoki, M; Haga, M; Hayashi, M; Nishigaki, R; Okudaira, K | 1 |
Alaei, S; Baharvand, H; Gourabi, H; Hatami, M; Hemmesi, K; Kiani, S; Masoudi, N; Nemati, S | 1 |
Cupić, V; Gojković-Bukarica, L; Heinle, H; Ivković, B; Novaković, R; Vladimirov, S | 1 |
Nilsson, MF; Ritchie, H; Webster, WS | 1 |
Dosen, PJ; Imtiaz, MS; Isbister, GK; Laver, DR; Thomas, PA; van Helden, DF | 1 |
Abu-Kishk, I; Berkovitch, M; Efrati, Y; Klin, B | 1 |
Grigoriev, A; Nikitina, A; Sidorova, A; Yaroshenko, I | 1 |
Karavana, SY; Önder, T; Rençber, S; Sarıışık, AM; Türkoğlu, GC | 1 |
Abdelghani, GM; Elghadban, HM; Mohamed, EA; Salem, AE | 1 |
5 review(s) available for lidocaine and nifedipine
Article | Year |
---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship | 2016 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
New antiarrhythmic drugs.
Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half-Life; Humans; Hypertension; Lidocaine; Metoprolol; Nadolol; Nifedipine; Propanolamines; Propranolol; Tocainide; Verapamil | 1983 |
Noninvasive tests of CYP3A enzymes.
Topics: Animals; Breath Tests; Cytochrome P-450 Enzyme System; Dapsone; Erythromycin; Humans; Hydrocortisone; Lidocaine; Liver; Midazolam; Nifedipine | 1994 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Diltiazem; Fissure in Ano; Headache; Humans; Indoramin; Injections, Intralesional; Lidocaine; Nifedipine; Nitroglycerin; Ointments | 2008 |
8 trial(s) available for lidocaine and nifedipine
Article | Year |
---|---|
Pharmacokinetics of oral lidocaine and nifedipine in patients with liver cirrhosis.
Topics: Administration, Oral; Adult; Anesthetics; Cross-Over Studies; Female; Hemodynamics; Humans; Lidocaine; Liver; Liver Cirrhosis; Male; Middle Aged; Nifedipine; Sensitivity and Specificity; Severity of Illness Index; Vasodilator Agents | 1996 |
Conservative treatment of acute thrombosed external hemorrhoids with topical nifedipine.
Topics: Acute Disease; Administration, Topical; Adult; Female; Hemorrhoids; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Pain Measurement; Prospective Studies; Thrombosis; Treatment Outcome | 2001 |
Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study.
Topics: Administration, Topical; Adolescent; Adult; Aged; Chronic Disease; Double-Blind Method; Drug Combinations; Female; Fissure in Ano; Humans; Hydrocortisone; Lidocaine; Male; Manometry; Middle Aged; Nifedipine; Prospective Studies; Recurrence; Treatment Outcome | 2002 |
Serum levels and possible haemodynamic effects following anorectal application of an ointment containing nifedipine and lignocaine : a study in healthy volunteers.
Topics: Administration, Topical; Adult; Anal Canal; Anesthetics, Local; Blood Pressure; Chromatography, High Pressure Liquid; Electrocardiography; Female; Heart Rate; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Ointments | 2006 |
Periprostatic nerve block (PNB) alone vs PNB combined with an anaesthetic-myorelaxant agent cream for prostate biopsy: a prospective, randomized double-arm study.
Topics: Aged; Anesthetics, Local; Biopsy, Needle; Drug Therapy, Combination; Epidemiologic Methods; Humans; Lidocaine; Male; Middle Aged; Nerve Block; Neuromuscular Depolarizing Agents; Nifedipine; Pain; Pain Measurement; Prostatic Neoplasms; Treatment Outcome; Ultrasonography, Interventional | 2009 |
Pharmacokinetics of anorectal nifedipine and lidocaine (lignocaine) ointment following haemorrhoidectomy: an open-label, single-dose, phase IV clinical study.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Anesthetics, Local; Area Under Curve; Blood Pressure; Chromatography, High Pressure Liquid; Drug Combinations; Electrocardiography; Female; Heart Rate; Hemorrhoids; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Ointments; Vasodilator Agents | 2009 |
Topical nifedipine with lidocaine ointment versus active control for pain after hemorrhoidectomy: results of a multicentre, prospective, randomized, double-blind study.
Topics: Adult; Anesthetics, Local; Calcium Channel Blockers; Double-Blind Method; Drug Combinations; Female; Hemorrhoids; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Ointments; Pain, Postoperative; Prospective Studies | 2010 |
Potential combination topical therapy of anal fissure: development, evaluation, and clinical study†.
Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Drug Combinations; Drug Compounding; Drug Therapy, Combination; Excipients; Female; Fissure in Ano; Gels; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Prospective Studies; Vasodilator Agents; Young Adult | 2018 |
72 other study(ies) available for lidocaine and nifedipine
Article | Year |
---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity.
Topics: Amines; Anesthetics, Local; Animals; Calcium Channel Blockers; Drug Evaluation, Preclinical; Heterocyclic Compounds; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Rabbits; Trachea | 1988 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Mice; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Substrate Specificity | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
[Prolongation of the effective refractory period on isolated guinea pig atria by some anti-arrhythmia agents: relevance in a comparison of their potentialities].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Lidocaine; Myocardial Contraction; Nifedipine; Verapamil | 1979 |
Effects of atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog.
Topics: Action Potentials; Anesthetics, Local; Animals; Atrioventricular Node; Benzazepines; Calcium; Coronary Circulation; Coronary Vessels; Diltiazem; Dogs; Female; Heart Conduction System; In Vitro Techniques; Injections; Lidocaine; Male; Neural Conduction; Nifedipine; Procaine; Quinidine; Vasodilator Agents; Verapamil | 1976 |
Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes.
Topics: Animals; Chlorpromazine; Dipyridamole; Disopyramide; Drug Interactions; In Vitro Techniques; Lidocaine; Liver; Male; Nifedipine; Ouabain; Propranolol; Quinidine; Rats; Rats, Wistar; Sodium; Taurocholic Acid; Verapamil | 1992 |
Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity.
Topics: Animals; Benzene Derivatives; Benzoflavones; Catalysis; Cholic Acid; Cholic Acids; Cytochrome P-450 Enzyme System; Enzyme Activation; Humans; Lidocaine; NADPH-Ferrihemoprotein Reductase; Nifedipine; Oxidation-Reduction; Phosphatidylcholines; Phosphatidylserines; Phospholipids; Rabbits; Rats; Testosterone | 1992 |
Effect of age and gender on the activity of human hepatic CYP3A.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Humans; Lidocaine; Microsomes, Liver; Middle Aged; Nifedipine; Oxidoreductases, N-Demethylating; Quinidine; Sex Factors; Smoking | 1992 |
Influence of action potential duration and resting potential on effects of quinidine, lidocaine and ethmozin on Vmax in guinea-pig papillary muscles.
Topics: Action Potentials; Animals; Female; Guinea Pigs; Lidocaine; Male; Membrane Potentials; Moricizine; Nifedipine; Papillary Muscles; Potassium; Quinidine; Time Factors | 1991 |
45Ca2+ movements induced by Ca2+ chloride in isolated rat aorta under K(+)-free conditions.
Topics: Amiloride; Animals; Aorta, Thoracic; Benzothiazoles; Calcium; Calcium Chloride; Calcium Radioisotopes; Flunarizine; In Vitro Techniques; Indomethacin; Lanthanum; Lidocaine; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Piperidines; Potassium; Rats; Thiazoles; Vasoconstriction | 1991 |
Early afterdepolarization induced by ryanodine in atrial fibers of mouse heart.
Topics: Action Potentials; Animals; Female; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Male; Mice; Nifedipine; Ryanodine; Tetrodotoxin | 1990 |
An experimental approach to the choice of antiarrhythmic therapy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil | 1986 |
Effects of bepridil on force development and transmembrane electrical activity of adult canine Purkinje strands: comparison with nisoldipine and lidocaine.
Topics: Animals; Bepridil; Calcium Channel Blockers; Dogs; Female; Heart Conduction System; Lidocaine; Male; Membrane Potentials; Nifedipine; Nisoldipine; Purkinje Fibers; Pyrrolidines; Time Factors | 1985 |
Leukotrienes (LTC4, LTD4) confer glass non-adherence on leukocytes of asthmatic individuals. Dependency on cyclooxygenase products and calcium ion.
Topics: Asthma; Calcium; Cell Adhesion; Child; Cyclooxygenase Inhibitors; Dinoprostone; Glass; Humans; Indomethacin; Lanthanum; Leukocyte Adherence Inhibition Test; Leukocytes; Lidocaine; Nifedipine; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; SRS-A; Trifluoperazine | 1985 |
Quinidine-nifedipine interaction.
Topics: Aged; Biological Availability; Drug Interactions; Humans; Lidocaine; Male; Myocardial Infarction; Nifedipine; Quinidine | 1985 |
Pharmacological agents to aid the clinician in combating myocardial ischaemia.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Coronary Disease; Dogs; Humans; Ion Channels; Lidocaine; Male; Myocardial Infarction; Myocardium; Nifedipine; Nitroglycerin; Rats; Sodium | 1983 |
Arterial spasm during renal angioplasty.
Topics: Adolescent; Adult; Aged; Angioplasty, Balloon; Arterial Occlusive Diseases; Arteriosclerosis; Child; Female; Fibromuscular Dysplasia; Heparin; Humans; Lidocaine; Male; Middle Aged; Nifedipine; Nitroglycerin; Premedication; Renal Artery; Spasm; Tolazoline; Verapamil | 1983 |
The effects of calcium channel inhibitors on twitches and noradrenaline contractions of the rat bisected vas deferens.
Topics: Animals; Calcium Channel Blockers; In Vitro Techniques; Ion Channels; Lidocaine; Male; Muscle Contraction; Nifedipine; Nitroprusside; Norepinephrine; Rats; Vas Deferens; Verapamil | 1983 |
The beneficial effect of nicardipine compared with nifedipine and verapamil in limiting myocardial infarct size in baboons.
Topics: Animals; Calcium Channel Blockers; Female; Hemodynamics; Lidocaine; Male; Myocardial Infarction; Nicardipine; Nifedipine; Nitroblue Tetrazolium; Papio; Pyridines; Verapamil | 1983 |
Antiarrhythmic evaluation of verapamil, nifedipine, perhexiline and skf 525-A in four canine models of cardiac arrhythmias.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Calcium; Dogs; Female; Heart Rate; Lidocaine; Male; Myocardial Contraction; Nifedipine; Perhexiline; Piperidines; Proadifen; Pyridines; Verapamil | 1981 |
A simple method for measurement of ureteric peristaltic function in vivo and the effects of drugs acting on ion channels applied from the ureter lumen in anesthetized rats.
Topics: 4-Aminopyridine; Anesthesia; Animals; Benzopyrans; Cromakalim; Glyburide; Ion Channels; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Rats; Rats, Sprague-Dawley; Ureter; Vasodilator Agents | 1993 |
Predicting the hepatic clearance of xenobiotics in humans from in vitro data.
Topics: Biological Availability; Chlorzoxazone; Cytochrome P-450 Enzyme System; Humans; Hydrocortisone; Lidocaine; Liver; Mathematics; Metabolic Clearance Rate; Mexiletine; Nifedipine; Predictive Value of Tests; Rifampin; Xenobiotics | 1994 |
Concentration dependence of lidocaine-induced irreversible conduction loss in frog nerve.
Topics: Action Potentials; Animals; Calcium Channels; Drug Interactions; In Vitro Techniques; Kinetics; Lidocaine; Nerve Block; Neural Conduction; Nifedipine; Peripheral Nervous System Diseases; Rana catesbeiana; Sciatic Nerve; Sensitivity and Specificity | 1994 |
Properties of calcium spikes revealed during GABAA receptor antagonism in hippocampal CA1 neurons from guinea pigs.
Topics: Animals; Bicuculline; Cadmium; Calcium; Calcium Channel Blockers; Electric Stimulation; Electrophysiology; Evoked Potentials; GABA-A Receptor Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Nifedipine; omega-Agatoxin IVA; Picrotoxin; Pyramidal Cells; Sodium Channel Blockers; Spider Venoms; Tetrodotoxin; Virulence Factors, Bordetella | 1997 |
Contribution of a voltage-sensitive calcium release mechanism to contraction in cardiac ventricular myocytes.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Guinea Pigs; Heart Ventricles; Lidocaine; Male; Membrane Potentials; Myocardial Contraction; Nifedipine; Ryanodine; Sodium Channel Blockers; Thapsigargin; Time Factors; Verapamil | 1998 |
Nervous control of alkaline secretion in the duodenum as studied by the use of cholera toxin in the anaesthetized rat.
Topics: Alkalies; Anesthesia; Anesthetics, Local; Animals; Atropine; Calcium Channel Blockers; Cholera Toxin; Duodenum; Granisetron; Hexamethonium; Lidocaine; Male; Muscarinic Antagonists; Myenteric Plexus; Nicotinic Antagonists; Nifedipine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists | 1998 |
N- and L-type calcium channel involvement in depolarization-induced suppression of inhibition in rat hippocampal CA1 cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Lidocaine; Male; Nickel; Nifedipine; omega-Conotoxin GVIA; Peptides; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1998 |
Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo.
Topics: Adrenergic Antagonists; Animals; ATP-Binding Cassette Transporters; Bacterial Proteins; Cephalexin; Cephalosporins; Hexamethonium; Intestinal Absorption; Jejunum; Lidocaine; Male; Membrane Transport Proteins; Microvilli; Nifedipine; Prazosin; Rats; Rats, Wistar; Yohimbine | 1999 |
Inhibition of germ tube formation by Candida albicans by local anesthetics: an effect related to ionic channel blockade.
Topics: Amides; Anesthetics, Local; Calcium; Candida albicans; Dose-Response Relationship, Drug; Ion Channels; Lanthanum; Lidocaine; Nifedipine; Ropivacaine; Verapamil | 2000 |
Sodium current in human jejunal circular smooth muscle cells.
Topics: Anesthetics, Local; Calcium Channel Blockers; Calcium Channels, L-Type; Humans; Jejunum; Kinetics; Lidocaine; Membrane Potentials; Molecular Sequence Data; Muscle, Smooth; NAV1.5 Voltage-Gated Sodium Channel; Nifedipine; Patch-Clamp Techniques; RNA, Messenger; Sequence Homology, Amino Acid; Sodium; Sodium Channels; Tetrodotoxin | 2002 |
Is topical nifedipine effective for chronic anal fissures?
Topics: Administration, Topical; Anesthetics, Local; Chronic Disease; Double-Blind Method; Evidence-Based Medicine; Fissure in Ano; Humans; Lidocaine; Nifedipine; Ointments; Pain Measurement; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome; Vasodilator Agents; Wound Healing | 2003 |
How inotropic drugs alter dynamic and static indices of cyclic myoplasmic [Ca2+] to contractility relationships in intact hearts.
Topics: Animals; Calcium; Digoxin; Dopamine; Guinea Pigs; Lidocaine; Muscle Contraction; Myocardial Contraction; Myocardium; Nifedipine; Signal Processing, Computer-Assisted; Ventricular Function; Ventricular Function, Left; Ventricular Pressure | 2003 |
Contractile effect of acetylcholine on isolated ampullar segment of Fallopian tubes.
Topics: Acetylcholine; Adult; Aged; Diamines; Fallopian Tubes; Female; Follicular Phase; Humans; Lidocaine; Luteal Phase; Mecamylamine; Menopause; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Piperidines; Pirenzepine; Verapamil | 2004 |
Negative inotropic drugs alter indexes of cytosolic [Ca(2+)]-left ventricular pressure relationships after ischemia.
Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cytosol; Diacetyl; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Lidocaine; Myocardial Ischemia; Myocardial Reperfusion Injury; Nifedipine; Osmolar Concentration; Pressure; Ventricular Function, Left | 2004 |
Contractile effect of acetylcholine on isolated isthmic segment of fallopian tubes.
Topics: Acetylcholine; Adult; Aged; Atropine; Diamines; Dose-Response Relationship, Drug; Fallopian Tubes; Female; Follicular Phase; Humans; Lidocaine; Luteal Phase; Mecamylamine; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Piperidines; Pirenzepine; Postmenopause; Receptors, Muscarinic | 2004 |
Intubation without premedication may worsen outcome for unconsciousness patients with intracranial hemorrhage.
Topics: Analgesics, Opioid; Anesthetics, Local; Anti-Anxiety Agents; Diazepam; Emergency Medicine; Female; Fentanyl; Glasgow Outcome Scale; Humans; Intracranial Hemorrhages; Intubation, Intratracheal; Lidocaine; Male; Middle Aged; Nicardipine; Nifedipine; Outcome and Process Assessment, Health Care; Pentazocine; Premedication; Retrospective Studies; Unconsciousness; Vasodilator Agents | 2005 |
Novel tissue engineered tubular heart tissue for in vitro pharmaceutical toxicity testing.
Topics: Animal Testing Alternatives; Animals; Apoptosis; Caspase 3; Collagen; Isoproterenol; Lidocaine; Microscopy, Confocal; Myocytes, Cardiac; Nifedipine; Rats; Tissue Engineering; Toxicity Tests; Xenobiotics | 2007 |
Drug assessment based on detection of L-glutamate released from C6 glioma cells using an enzyme-luminescence method.
Topics: 4-Aminopyridine; Animals; Brain Neoplasms; Carbamazepine; Cell Line, Tumor; Enzymes; Flunarizine; Glioma; Glutamic Acid; Lidocaine; Luminescence; Nickel; Nifedipine; Rats; Veratridine | 2008 |
Membrane time constant during internal defibrillation strength shocks in intact heart: effects of Na+ and Ca2+ channel blockers.
Topics: Animals; Calcium Channel Blockers; Cell Membrane; Computer Simulation; Dose-Response Relationship, Drug; Electric Countershock; In Vitro Techniques; Kinetics; Lidocaine; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Nifedipine; Rabbits; Sodium Channel Blockers | 2009 |
Human CYP3A4-introduced HepG2 cells: in vitro screening system of new chemicals for the evaluation of CYP3A4-inhibiting activity.
Topics: Ammonia; Animals; Atorvastatin; Cell Line, Tumor; Cricetinae; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Heptanoic Acids; Humans; Ketoconazole; Lidocaine; Nifedipine; Pyrroles | 2008 |
Contribution of rat pulmonary metabolism to the elimination of lidocaine, midazolam, and nifedipine.
Topics: Animals; Drug Administration Routes; Drug Evaluation, Preclinical; Forecasting; In Vitro Techniques; Lidocaine; Lung; Male; Microsomes; Microsomes, Liver; Midazolam; Nifedipine; Rats; Rats, Wistar | 2010 |
Long-term self-renewable feeder-free human induced pluripotent stem cell-derived neural progenitors.
Topics: Antigens, Differentiation; Calcium Channel Blockers; Cell Culture Techniques; Cell Differentiation; Cell Line; Cell Shape; Cryopreservation; Gene Expression Profiling; Humans; Induced Pluripotent Stem Cells; Intermediate Filament Proteins; Lidocaine; Membrane Potentials; Nerve Tissue Proteins; Nestin; Neural Stem Cells; Neurons; Nifedipine; Potassium Channel Blockers; SOXB1 Transcription Factors; Tetraethylammonium; Transcription, Genetic | 2011 |
The novel phenylpropiophenone derivates induced relaxation of isolated rat aorta.
Topics: Animals; Aorta; In Vitro Techniques; Lidocaine; Male; Nifedipine; Phenylephrine; Propafenone; Propiophenones; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilation | 2012 |
The effect on rat embryonic heart rate of Na+, K+, and Ca2+ channel blockers, and the human teratogen phenytoin, changes with gestational age.
Topics: Animals; Calcium Channel Blockers; Female; Gestational Age; Heart Rate, Fetal; Lidocaine; Nifedipine; Phenethylamines; Phenytoin; Potassium Channel Blockers; Pregnancy; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sulfonamides | 2013 |
Pharmacological approaches that slow lymphatic flow as a snakebite first aid.
Topics: Animals; Elapid Venoms; Female; First Aid; Humans; Lidocaine; Lymphatic System; Male; Nifedipine; Rats; Respiration; Snake Bites | 2014 |
Anal fissure in children: a 10-year clinical experience with nifedipine gel with lidocaine.
Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Child, Preschool; Drug Combinations; Female; Fissure in Ano; Humans; Infant; Lidocaine; Male; Nifedipine; Recurrence; Retrospective Studies; Treatment Outcome; Vasodilator Agents; Wound Healing | 2016 |
Development of a HPLC-MS/MS method for the simultaneous determination of nifedipine and lidocaine in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Lidocaine; Nifedipine; Reproducibility of Results; Tandem Mass Spectrometry | 2016 |
Preparation and characterization of textile-based carrier systems for anal fissure treatment.
Topics: Alginates; Anesthetics, Local; Drug Carriers; Drug Delivery Systems; Drug Liberation; Fissure in Ano; Glucuronic Acid; Hexuronic Acids; Humans; Lidocaine; Nifedipine; Tampons, Surgical; Textiles; Vasodilator Agents | 2017 |