lidocaine and nicardipine

lidocaine has been researched along with nicardipine in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.41)18.7374
1990's6 (22.22)18.2507
2000's13 (48.15)29.6817
2010's6 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA1
Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Jolivette, LJ; Ward, KW1
Jolivette, LJ; Nagilla, R; Ward, KW1
Colby, DW; Collins, SR; Feng, BY; May, BC; Prusiner, SB; Shoichet, BK; Toyama, BH; Weissman, J; Wille, H1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Artursson, P; Mateus, A; Matsson, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brown, BS1
Alps, BJ; Calder, C; Wilson, A1
Honda, N; Miyagawa, A; Mizutani, A; Oyama, T; Taniguchi, K1
Akaike, N; Kobayashi, T; Miyake, N; Nishioka, K; Omura, T1
Attolini, L; Bruguerolle, B; Gantenbein, M; Grignon, S; Jacob, D1
Albat, B; Nargeot, J; Quignard, JF; Richard, S; Ryckwaert, F1
Cromeens, DM; Evans, GR; Gherardini, G; Gürlek, A; Joly, GA; Kilbourn, RG; Langstein, H; Lundeberg, T; Sukumaran, AV; Wang, B; Williams, J1
Strichartz, GR; Xiong, Z1
Adachi, N; Arai, T; Nagaro, T; Shimizu, I; Tabo, E; Yorozuya, T1
Boussofara, M; Bracco, D; Chrayti, H; Ravussin, P1
Hiroshi, N; Katoh, H; Okada, Y; Sakamoto, T; Shima, K; Tuzuki, N; Yanagawa, Y1
Koolen, PG; Lee, BT; Lin, SJ; Ricci, JA; Shah, J; Tobias, AM1

Reviews

1 review(s) available for lidocaine and nicardipine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for lidocaine and nicardipine

ArticleYear
The effect of calcium channel antagonist administered by iontophoresis on the pain threshold.
    Acta anaesthesiologica Belgica, 1995, Volume: 46, Issue:2

    Topics: Adult; Calcium Channel Blockers; Diltiazem; Drug Combinations; Female; Humans; Iontophoresis; Lidocaine; Male; Nicardipine; Pain; Sensory Thresholds; Time Factors; Verapamil

1995
[Comparison of three protocols in the control of cardiovascular response to suspended laryngoscopy in ENT surgery].
    La Tunisie medicale, 2004, Volume: 82, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Female; Heart Rate; Humans; Laryngoscopy; Lidocaine; Male; Middle Aged; Nicardipine; Postoperative Complications; Propanolamines; Risk Factors

2004

Other Studies

24 other study(ies) available for lidocaine and nicardipine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Rational use of in vitro P-glycoprotein assays in drug discovery.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera

2001
Identification and prediction of promiscuous aggregating inhibitors among known drugs.
    Journal of medicinal chemistry, 2003, Oct-09, Volume: 46, Issue:21

    Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship

2003
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human.
    Xenobiotica; the fate of foreign compounds in biological systems, 2005, Volume: 35, Issue:2

    Topics: Administration, Oral; Animals; Area Under Curve; Dogs; Haplorhini; Humans; Models, Statistical; Rats; Software; Species Specificity; Xenobiotics

2005
Small-molecule aggregates inhibit amyloid polymerization.
    Nature chemical biology, 2008, Volume: 4, Issue:3

    Topics: Acetophenones; Animals; Benzopyrans; beta-Lactamase Inhibitors; beta-Lactamases; Clioquinol; Congo Red; Detergents; Flavanones; Mice; Microscopy, Electron, Transmission; Molecular Structure; Molecular Weight; Particle Size; Peptide Termination Factors; Phenolphthaleins; Phthalimides; Prions; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sensitivity and Specificity; Structure-Activity Relationship

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Species independence in brain tissue binding using brain homogenates.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Electrophysiological effects of ACC-9358, a novel class I antiarrhythmic agent, on isolated canine Purkinje fibers and ventricular muscle.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Female; Heart; Heart Conduction System; Heart Ventricles; In Vitro Techniques; Lidocaine; Male; Nicardipine; Potassium; Purkinje Fibers; Pyrrolidines

1989
The beneficial effect of nicardipine compared with nifedipine and verapamil in limiting myocardial infarct size in baboons.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:6

    Topics: Animals; Calcium Channel Blockers; Female; Hemodynamics; Lidocaine; Male; Myocardial Infarction; Nicardipine; Nifedipine; Nitroblue Tetrazolium; Papio; Pyridines; Verapamil

1983
Ca(2+)-antagonistic action of bevantolol on hypothalamic neurons in vitro: its comparison with those of other beta-adrenoceptor antagonists, a local anesthetic and a Ca(2+)-antagonist.
    Brain research, 1996, Jan-15, Volume: 706, Issue:2

    Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Calcium Channel Blockers; Hypothalamus, Middle; Lidocaine; Neurons; Nicardipine; Patch-Clamp Techniques; Propanolamines; Propranolol; Rats; Rats, Wistar

1996
Effects of calcium antagonists on binding of local anesthetics to plasma proteins and erythrocytes in mice.
    Pharmacology, 1996, Volume: 53, Issue:4

    Topics: Anesthetics, Local; Animals; Blood Proteins; Bupivacaine; Calcium Channel Blockers; Diltiazem; Erythrocytes; In Vitro Techniques; Lidocaine; Male; Mice; Nicardipine; Protein Binding; Verapamil

1996
A novel tetrodotoxin-sensitive Na+ current in cultured human coronary myocytes.
    Circulation research, 1997, Volume: 80, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adult; Calcium Channel Agonists; Calcium Channel Blockers; Cnidarian Venoms; Coronary Vessels; Dose-Response Relationship, Drug; Humans; Ion Channel Gating; Lidocaine; Male; Middle Aged; Muscle, Smooth, Vascular; Neurotoxins; Nicardipine; Patch-Clamp Techniques; Sodium Channels; Tetrodotoxin; Veratridine

1997
Drug-induced vasodilation in an in vitro and in vivo study: the effects of nicardipine, papaverine, and lidocaine on the rabbit carotid artery.
    Plastic and reconstructive surgery, 1997, Volume: 100, Issue:6

    Topics: Administration, Topical; Anastomosis, Surgical; Animals; Blood Pressure; Carotid Arteries; Dose-Response Relationship, Drug; Follow-Up Studies; Ischemia; Isotonic Solutions; Lidocaine; Microcirculation; Microsurgery; Monitoring, Physiologic; Nicardipine; Norepinephrine; Papaverine; Rabbits; Regional Blood Flow; Single-Blind Method; Surgical Flaps; Ultrasonography, Doppler; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

1997
Inhibition by local anesthetics of Ca2+ channels in rat anterior pituitary cells.
    European journal of pharmacology, 1998, Dec-11, Volume: 363, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Calcium Channel Blockers; Clone Cells; Dihydropyridines; Dose-Response Relationship, Drug; Lidocaine; Membrane Potentials; Nicardipine; Patch-Clamp Techniques; Pituitary Gland, Anterior; Rats

1998
[Effects of intravenous nicardipine, prostaglandin E1, nitroglycerin, sodium nitroprusside, and epidural lidocaine on hepatic and renal blood flow during hypotensive anesthesia].
    Masui. The Japanese journal of anesthesiology, 2000, Volume: 49, Issue:12

    Topics: Aged; Alprostadil; Anesthesia, General; Arthroplasty, Replacement, Hip; Female; Glomerular Filtration Rate; Humans; Hypotension, Controlled; Infusions, Intravenous; Injections, Epidural; Intraoperative Period; Kidney Tubules; Lidocaine; Liver Circulation; Middle Aged; Nicardipine; Nitroglycerin; Nitroprusside; Renal Circulation; Vasodilator Agents

2000
Intubation without premedication may worsen outcome for unconsciousness patients with intracranial hemorrhage.
    The American journal of emergency medicine, 2005, Volume: 23, Issue:2

    Topics: Analgesics, Opioid; Anesthetics, Local; Anti-Anxiety Agents; Diazepam; Emergency Medicine; Female; Fentanyl; Glasgow Outcome Scale; Humans; Intracranial Hemorrhages; Intubation, Intratracheal; Lidocaine; Male; Middle Aged; Nicardipine; Nifedipine; Outcome and Process Assessment, Health Care; Pentazocine; Premedication; Retrospective Studies; Unconsciousness; Vasodilator Agents

2005
Comparing the Outcomes of Different Agents to Treat Vasospasm at Microsurgical Anastomosis during the Papaverine Shortage.
    Plastic and reconstructive surgery, 2016, Volume: 138, Issue:3

    Topics: Administration, Topical; Aged; Anastomosis, Surgical; Drug Substitution; Female; Free Tissue Flaps; Graft Survival; Humans; Intraoperative Complications; Lidocaine; Microsurgery; Middle Aged; Nicardipine; Outcome Assessment, Health Care; Papaverine; Parasympatholytics; Retrospective Studies; Vasoconstriction

2016