lidocaine has been researched along with monoethylglycinexylidide in 316 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (15.82) | 18.7374 |
| 1990's | 166 (52.53) | 18.2507 |
| 2000's | 78 (24.68) | 29.6817 |
| 2010's | 18 (5.70) | 24.3611 |
| 2020's | 4 (1.27) | 2.80 |
| Authors | Studies |
|---|---|
| Nelson, SD; Nelson, WL; Trager, WF | 1 |
| Embro, WJ; Munson, ES | 1 |
| Atkinson, AJ; Collinsworth, KA; Harrison, DC; Perlroth, F; Strong, JM; Winkle, RA | 1 |
| Nation, RL; Selig, M; Triggs, EJ | 1 |
| Branson, RD; Davis, K; Johnson, DJ; Purcell, PN; Schroeder, TJ | 1 |
| Balderson, GA; Chen, Y; Hickman, PE; Lynch, SV; Potter, JM; Strong, RW | 1 |
| Heng, KK; Lim, NK; Lim, SM; Poh, LH; Seah, ML | 1 |
| Chen, Y; Potter, JM | 1 |
| Becker, H; Ebener, T; Groteguth, R; Niederau, C; Stremmel, W; Strohmeyer, G; Wojdat, R; Zoedler, M | 1 |
| A-Kader, HH; Balistreri, WF; Gremse, DA; Pedersen, SH; Pesce, AJ; Rossi, SJ; Ryckman, FC; Schroeder, TJ; Vine, WH | 1 |
| Sallie, RW; Tredger, JM; Williams, R | 1 |
| Chen, Y; Potter, JM; Ravenscroft, PJ | 2 |
| Balderson, G; Hickman, PE; Lynch, SV; Potter, JM; Strong, R | 1 |
| Fumagalli, C; Zoppi, F | 1 |
| Pond, SM; Rivory, LP; Roberts, MS | 1 |
| Balderson, G; Henderson, A; Hickman, PE; Lynch, SV; Potter, JM; Scott, CB; Strong, RW; Walker, NI | 1 |
| Allam, M; du Souich, P; Hartemann, D; Saunier, C | 1 |
| Sanyal, AJ; Zfass, AM | 1 |
| Gray, MR; Saville, BA; Tam, YK | 1 |
| Bargetzi, M; Luo, HS; Meyer, B; Renner, EL; Stalder, GA | 1 |
| Chiba, M; Fujita, S; Masubuchi, Y; Suzuki, T; Umeda, S | 1 |
| Alexander, JW; Balistreri, WF; Brunson, ME; Pedersen, SH; Penn, I; Pesce, AJ; Ryckman, FC; Schroeder, TJ; Tchervenkov, JI; Tressler, TP | 1 |
| Adam, R; Astarcioglu, I; Azoulay, D; Bao, YM; Bismuth, H; Bonhomme, L; Fredj, G | 1 |
| Ban, T; Hiraoka, I; Itoh, M; Oshita, S; Sakabe, T | 1 |
| Binder, L; Burdelski, M; Lautz, HU; Oellerich, M; Pichlmayr, R | 1 |
| Belzer, FO; D'Alessandro, AM; Hafez, GR; Hoffmann, RM; Kalayoglu, M; Knechtle, SJ; Lorentzen, D; Pirsch, JD; Reed, A; Sollinger, HW | 1 |
| Beyrau, R; Burdelski, M; Gubernatis, G; Lamesch, P; Lautz, HU; Oellerich, M; Pichlmayr, R; Ringe, B; Wittekind, C | 1 |
| Angelo, HR; Laub, MS; Milman, N; Munch, EP | 1 |
| Druckenbrod, RW; Mendenhall, CL; Myre, SA; Schroeder, TJ; Stanberry, EA | 1 |
| Barlow, JC; Lener, ME; Sands, MF; Watson, WA; Wilton, JH | 1 |
| Coutts, RT; Finegan, BA; Ke, J; Koo, WW; Tam, YK | 1 |
| Ban, T; Hiraoka, I; Morimoto, Y; Oshita, S | 1 |
| Burdelski, M; Herrmann, H; Lautz, HU; Oellerich, M; Schmidt, FW; Schulz, M | 1 |
| Coutts, RT; Gray, MR; Ke, J; Tam, YK; Wyse, DG | 1 |
| Barstow, L; Small, RE | 1 |
| Beyrau, R; Burdelski, M; Gubernatis, G; Lamesch, P; Oellerich, M; Pichlmayr, R; Ringe, B | 1 |
| A-Kader, HH; Balistreri, WF; Gremse, DA; Schroeder, TJ | 1 |
| Yamane, J | 1 |
| Bunzendahl, H; Burdelski, M; Gubernatis, G; Herrmann, H; Lamesch, P; Oellerich, M; Pichlmayr, R; Ringe, B | 1 |
| al-Asady, SA; Black, GL; Lennard, MS; Tucker, GT; Woods, HF | 1 |
| Angelo, H; Bach, FW; Dejgård, A; Ekman, R; Jensen, S; Kastrup, J; Petersen, P | 1 |
| Aoyama, T; Bargetzi, MJ; Gonzalez, FJ; Meyer, UA | 1 |
| Asada, A; Fujimori, M; Fujita, S; Funae, Y; Imaoka, S; Nakahira, Y; Oda, Y | 1 |
| Alexander, JW; Brunson, ME; Gremse, DA; Mansour, ME; Penn, I; Pesce, AJ; Ryckman, FC; Schroeder, TJ; Suchy, FJ; Theuerling, AW | 1 |
| Bornscheuer, A; Burdelski, M; Gubernatis, G; Lamesch, P; Luebbe, N; Oellerich, M; Raith, H; Raude, E; Ringe, B; Scheruhn, M | 1 |
| Estes, NA; Garan, H; Greenblatt, DJ; Manolis, AS; Ruskin, JN | 1 |
| Takata, T | 1 |
| du Souich, P; Gariépy, L; Marleau, S; Ong, H | 1 |
| Satoh, Y | 1 |
| Bortfeld, S; Burdelski, M; Kämmerling, C; Lamesch, P; Neuhaus, P; Oellerich, M; Raith, H; Raude, E; Ringe, B; Scheruhn, M | 1 |
| Burdelski, M; Lamesch, P; Oellerich, M; Pichlmayr, R; Raith, H; Raude, E; Ringe, B; Scheruhn, M; Schmidt, FW; Schulz, M | 1 |
| Hanawa, K; Hasegawa, Y; Kawamoto, T; Ohno, H; Saegusa, Y; Watanabe, M | 1 |
| Heinzow, BG; McLean, AJ; Somogyi, A | 1 |
| Elliott, HL; Kelman, AW; Meredith, PA; Thomson, AH; Whiting, B | 1 |
| Clements, MJ; Endrenyi, L; Feuer, KF; Nelson, SD; Pang, KS; Terrell, JA | 1 |
| Cross, R; Foster, J; Patterson, JH; Powell, JR; Wargin, W | 1 |
| Hovi-Viander, M; Kanto, J; Laurikainen, E; Lindberg, R | 1 |
| Kuhnert, BR; Kuhnert, PM; Philipson, EH; Pimental, R; Syracuse, CD; Zuspan, KJ | 1 |
| Kreul, JF; Melby, MJ; Raehl, CL | 1 |
| Cusson, J; Lawand, S; Matthews, C; Nattel, S; Talajic, M | 1 |
| Benjamin, DM; Greenblatt, DJ; Harmatz, JS; Willis, CR; Zinny, MA | 1 |
| Echizen, H; Inoue, R; Ishizaki, T; Kushida, K; Suganuma, T; Tomono, Y | 1 |
| Crouch, DJ; Deyman, ME; Finkle, BS; Margot, P; Peat, MA | 1 |
| Duce, BR; Smith, ER | 1 |
| Ishizaki, T; Kushida, K; Oka, K; Suganuma, T | 1 |
| Broughton, A; Grant, AO; Klinger, JK; Stambler, BS; Starmer, CF; Strauss, HC | 1 |
| Barchowsky, A; Klinger, JK; Luzzi, FA; Strauss, HC; Wenger, TL | 1 |
| Kanto, J; Laurikainen, E; Lindberg, R; Marttila, R | 1 |
| Baldwin, RP; Halbert, MK | 1 |
| Abernethy, DR; Benjamin, DM; Greenblatt, DJ; Willis, CR | 1 |
| Kuhnert, BR; Philipson, EH; Syracuse, CD | 1 |
| Evers, H; Luostarinen, V; Lyytikäinen, MT; Wahlén, A | 1 |
| Drayer, DE; Lorenzo, B; Reidenberg, MM; Werns, S | 1 |
| Lennard, MS; Tucker, GT; Woods, HF | 1 |
| Bridges, RR; Hawkins, JD; Jennison, TA | 1 |
| Atkinson, AJ; Davison, R; Parker, M | 1 |
| Jones, DA; McBurney, A; Stanley, PJ; Tovey, C; Ward, JW | 1 |
| Dornbusch, J; Rothstein, P; Shaywitz, BA | 1 |
| Barchowsky, A; Routledge, PA; Shand, DG; Stargel, WW | 1 |
| Aarons, LJ; Bending, MR; Bennett, PN; Rowland, M; Steiner, JA | 1 |
| Davis, LE; Neff-Davis, CA; Wilcke, JC | 1 |
| Waller, ES | 1 |
| Fukuda, S; Takeshita, H; Toda, N | 1 |
| Bomhard, M; Dorer, J; Joeres, R; Keller, F; Klinker, H; Richter, E; Zilly, W | 1 |
| Böhrer, H; Böttiger, BW; Martin, E; Schmidt, H; Schröter, J; Wandel, C | 1 |
| Bihari, DJ; Dalton, RN; Mason, RC; Maynard, ND; Smithies, MN | 1 |
| Cakaloglu, Y; Devlin, J; Tredger, JM; Williams, R | 1 |
| Armstrong, VW; Kaltefleiter, M; Loss, M; Luy-Kaltefleiter, M; Oellerich, M; Ringe, B; Schütz, E; Wieland, E; Winkler, M | 1 |
| Armstrong, VW; Helmhold, M; Kaltefleiter, M; Luy, M; Oellerich, M; Ringe, B; Schütz, E; Wieland, E | 1 |
| De Bac, C; Duca, F; Lecce, R; Livoli, D; Pasquazzi, C; Taliani, G | 1 |
| Armstrong, VW; Lehmann, U; Oellerich, M; Pape, D; Regel, G; Schütz, E | 1 |
| Asada, A; Fujimori, M; Kariya, N; Nakamoto, T; Nishi, S; Oda, Y | 1 |
| Kaminski, DL; Li, AP; Rasmussen, A; Xu, L | 1 |
| Broughan, TA; Castellani, WJ; Hermann, RE; Malchesky, PS; Nakayama, S; Sato, N; Tanaka, J; Vogt, DP; Walsh, RM | 1 |
| Nacke, A; Reichel, C; Sauerbruch, T; Spengler, U; Sudhop, T; Wienkoop, G | 1 |
| Arvela, P; Bäckstrom, M; Pelkonen, O; Rautio, A; Sotaniemi, EA | 1 |
| Bianchi, GP; Fabbri, A; Marchesini, G | 1 |
| Shaw-Stiffel, TA; Ziebell, J | 1 |
| Amiot, B; Groehler, K; Hu, MY; Hu, WS; Mann, HJ; Olson, D; Rao, S; Remmel, RP; Shatford, RA; Sielaff, TD | 1 |
| Chamelian, M; du Souich, P; Lécrivain, A; Robichaud, A | 1 |
| Baue, AE; Chandel, B; Jellinek, M; Kurtz, M; Matthews, M; Rana, WU; Shapiro, MJ | 1 |
| Nacke, A; Reichel, C; Spengler, U; Wienkoop, G | 1 |
| Attolini, L; Bruguerolle, B; Lorec, AM; Roucoules, X | 1 |
| Beyrau, R; Christians, U; Esselmann, H; Kaltefleiter, M; Kohlhaw, K; Linck, A; Luy, M; Oellerich, M; Ringe, B; Sürig, T | 1 |
| Bevilacqua, G; Campanella, PG; Collecchi, P; Della Capanna, S; Di Stefano, R; Mosca, F; Pietrabissa, A; Scarcello, E; Turini, L | 1 |
| Biceglia, O; Bottiglieri, ME; Costanzo, A; Forte, G; Grimaldi, E; Rocco, P; Rossi, R; Zampella, G | 1 |
| Watkins, PB | 1 |
| Cerra, FB; Hu, MY; Sielaff, TD | 1 |
| Ambrosino, G; Borin, L; Brolese, A; Burra, P; Carraro, P; Cillo, U; Cionfoli, M; Tedeschi, U; Varagnolo, M; Zanus, G | 1 |
| Alvarez, S; Arzani, L; Borzone, S; Caglieris, S; Campo, N; Celle, G; Lantieri, PB; Risso, D; Testa, R | 1 |
| Andersson, T; Bannister, J; Lamont, M; Noble, DW; Scott, DB | 1 |
| Cerra, FB; Hu, WS; Mann, HJ; Nyberg, SL; Peshwa, MV; Remmel, RP | 1 |
| Fernández-Trigo, V; Marco, C; Steves, MA; Veloso, EV | 1 |
| Aimo, G; Arrigoni, A; Benedetti, P; Cappello, N; Gindro, T; Meloni, A; Molino, GP; Rizzetto, M; Verme, G | 1 |
| Alvarez, S; Borzone, S; Caglieris, S; Campo, N; Testa, R; Zentilin, P | 1 |
| Balderson, GA; Burrow, B; Henderson, A; Hickman, PE; Lynch, SV; Ong, TH; Potter, JM; Strong, RW; Wright, M | 1 |
| Miyata, M; Sakurabayashi, I; Seo, N; Shimanuki, K; Soda, K; Yamanaka, T; Yoshida, Y | 1 |
| Armstrong, VW; Burdelski, M; Hartmann, H; Oellerich, M; Polzien, F; Ringe, B; Schütz, E | 1 |
| Bendixen, D; Flachs, H; Halvorsen, AC; Hjelt, K | 1 |
| Contos, MJ; Duckworth, PF; Edinboro, LE; Luketic, VA; Mills, AS; Poklis, A; Purdum, PP; Sanyal, AJ; Shiffman, ML | 1 |
| Buckels, JA; Da Silva, RF; Harrison, RF; Hubscher, SG; Karayalçin, K; Mayer, AD; McMaster, P; Mirza, DF | 1 |
| Gross, AS; Pritchard-Davies, R; Shenfield, GM | 1 |
| Abdulnour, I; Bowkett, J; Gleeson, A; Hardy, KJ; Jones, RM; Michell, ID; Pzybylowski, G | 1 |
| Boni, M; Caputo, M; Frameglia, M; Guglielmi, A; Schinella, M; Veraldi, GF | 1 |
| Alfani, D; Berloco, P; Bruzzone, P; Cortesini, R; Rossi, M | 1 |
| Balderson, G; Henderson, A; Hickman, PE; Lynch, SV; Potter, JM; Strong, RW; Wright, M | 1 |
| Luo, H; Meyer-Wyss, B; Renner, E; Scholer, A | 1 |
| Deng, JF; Huang, YS; Lee, SD; Lin, YF; Lo, KJ; Lu, RH; Wang, YJ; Wu, JC | 1 |
| Reichen, J | 1 |
| Kashii, A; Kiyozaki, H; Miyata, M; Sakurabayashi, I; Seo, N; Shimanuki, K; Suzuki, W | 1 |
| de Ville de Goyet, J; Feyaerts, A; Hausleithner, V; Lambotte, L; Lerut, J; Otte, JB; Reding, R; Wallemacq, P | 1 |
| Dusci, LJ; Hackett, LP; Ilett, K; Lebedevs, TH; Roberts, MJ; Wojnar-Horton, RE; Yapp, P | 1 |
| Balderson, G; Henderson, A; Hickman, PE; Lynch, SV; Potter, JM; Strong, RW; Walker, NI; Wright, M | 1 |
| Kai, T; Kiyozaki, H; Miyata, M; Sakurabayashi, I; Satake, M; Shimanuki, K; Shinohara, K; Soda, K; Suzuki, W | 1 |
| Bermudo, L; Durán, JA | 1 |
| Fisher, RA; Luketic, VA; Posner, MP; Purdum, PP; Sanyal, AJ; Shiffman, ML | 1 |
| Burdelski, M; Hartmann, H; Lautz, HU; Oellerich, M; Pichlmayr, R; Ringe, B | 1 |
| Adam, R; Astarcioglu, I; Azoulay, D; Bao, YM; Bismuth, H; Bonhomme, L; Chiche, L; Fredj, G; Lemoine, A | 1 |
| Davies, EA; Elkhammas, EA; Ferguson, RM; Greenson, J; Henry, ML; Salazar, A; Tesi, RJ | 1 |
| Broccoli, AV; Ishitani, MB; Pruett, TL; Rosenlof, LK; Sawyer, RG; Stevenson, WC | 1 |
| Edinboro, LE; Fisher, RA; Luketic, VA; Posner, MP; Purdum, PP; Raymond, P; Sanyal, AJ; Shiffman, ML | 1 |
| Allin, R; Hickman, R; Lotz, Z; Mets, B; Van Dyk, J | 1 |
| Alfani, D; Bachetoni, A; Berloco, P; Bruzzone, P; Carboni, F; Casciaro, G; Cortesini, R; Iappelli, M; Marciani, A; Rossi, M | 1 |
| Adam, R; Azoulay, D; Beaune, P; Bismuth, H; Dolizy, I; Fredj, G; Gries, JM; Lemoine, A | 1 |
| Aita, P; Borsatti, E; Cannizzaro, R; Freschi, A; Galligioni, E; Monfardini, S; Robieux, I; Sorio, R; Vitali, V | 1 |
| Ishikawa, A; Misawa, S; Tanaka, E | 1 |
| Barr, SB; Duffy, LF; Kerzner, B; Seeff, L; Soldin, SJ | 1 |
| O'Neal, CL; Poklis, A | 1 |
| Jonas, MM; LaQuaglia, MP; Leichtner, AM; Shamberger, RC | 1 |
| Amoroso, B; Campagnutta, E; Cannizzaro, R; Robieux, I; Sorio, R; Tumolo, S; Valentini, M | 1 |
| Freys, G | 1 |
| Autschbach, R; Dalichau, H; Falk, V; Lange, H; Mohr, FW; Oellerich, M; Walther, T | 1 |
| Ben-Zvi, Z; Goldin, G; Van Creveld, C; Yagil, R | 1 |
| Ferrara, SD; Frison, G; Mazzo, M; Orlando, R; Padrini, R; Palatini, P; Tedeschi, L; Zordan, R | 1 |
| du Souich, P; Lê, KT; Maurice, H | 1 |
| Becker, H; Ebener, C; Roeher, HD; Zoedler, T | 1 |
| Luketic, VA; Sanyal, AJ; Shiffman, ML; Thompson, EB | 1 |
| Armstrong, VW; Burdelski, M; Nolte-Buchholtz, S; Oellerich, M; Schütz, E | 1 |
| Balderson, GA; Henderson, A; Hickman, PE; Lynch, SV; Potter, JM; Strong, RW | 1 |
| Contis, J; Fairchild, R; Kaminski, D; Solomon, H | 1 |
| Armstrong, VW; Burdelski, M; Kaltefleiter, M; Luy-Kaltefleiter, M; Oellerich, M; Ringe, B; Schütz, E | 1 |
| Collins, JM; Parker, RJ; Strong, JM | 1 |
| Biceglia, O; De Biasio, MC; De Crescenzo, OD; Forte, GB; Minerva, A; Paceli, M; Rocco, P | 1 |
| Bertolissi, A; Cartei, G; Cioschi, B; Marsilio, P; Rizzi, V; Tabaro, G | 1 |
| Beale, R; Bihari, DJ; Dalton, RN; Mason, RC; Maynard, ND; Smithies, MN | 1 |
| Beste, M; Breuer, N; Eigler, FW; Erhard, J; Goebell, H; Lange, R; von Schönfeld, J; Zotz, RB | 1 |
| Lehmann, U; Oellerich, M; Pape, D; Regel, G | 1 |
| Beste, M; Breuer, N; Eigler, FW; Erhard, J; Goebell, H; Lange, R; Mahl, M; von Schönfeld, J; Zotz, RB | 1 |
| Fujimori, M; Funae, Y; Imaoka, S; Nakamoto, T; Oda, Y | 1 |
| Hahn, C; Lüers, C; Nacke, A; Pohl, C; Reichel, C; Sauerbruch, T; Spengler, U; Sudhop, T; Wienkoop, G | 1 |
| Andreeva, M; Armstrong, VW; Niedmann, PD; Oellerich, M; Schütz, E; Wieland, E | 1 |
| Beeker, T; Corno, V; Demetriou, AA; Eguchi, S; Hewitt, WR; Kamlot, A; Middleton, Y; Rozga, J | 1 |
| Groothuis, GM; Hof, IH; Kranenburg, K; Maring, JK; Meijer, DK; Merema, M; Olinga, P; Slooff, MJ | 1 |
| Boudjema, K; Calon, B; Freys, G; Hamel, G; Otteni, JC; Pain, L; Pottecher, T | 1 |
| Orlando, R; Palatini, P | 1 |
| DiBisceglie, AM; Elin, RJ; Fried, MW; Kleiner, DE; Ruddel, M; Sampson, M | 1 |
| Oellerich, M; Potter, JM | 1 |
| Ghent, CN; Wall, WJ | 1 |
| Boudjema, K; Clever, B; Freys, G; Lehmann, C; Levy, S; Saada, A; Steib, A | 1 |
| Adam, R; Azoulay, D; Bismuth, H; Davoll, S; Debuire, B; Lemoine, A; Pham, P; Salvucci, M | 1 |
| Horsmans, Y; Lambotte, L; Leclercq, I; Saliez, A; Wallemacq, PE | 1 |
| Walson, PD | 1 |
| Alvarez, S; Arzani, L; Caglieris, S; Campo, N; Celle, G; Giannini, E; Lantieri, PB; Risso, D; Testa, R | 1 |
| Cifuentes, A; García-Valdecasas, JC; Gonzalez, FX; Grande, L; López-Boado, MA; Net, M; Palacín, J; Rimola, A; Rull, R; Tabet, J; Taurá, P; Valero, R; Visa, J | 1 |
| Actis, GC; Arrigoni, A; Benedetti, P; Cappello, N; Gindro, T; Martinasso, G; Perardi, S; Rizzetto, M; Rosina, F; Verme, G | 1 |
| Angelo, HR; Laub, M; Milman, N; Munch, EP | 1 |
| Merion, RM; Williams, TC; Woodside, KJ | 1 |
| Borzone, S; Caglieris, S; Ghia, M; Giannini, E; Mattioli, F; Mereto, E; Risso, D; Testa, R | 1 |
| Armstrong, VW; Niedmann, PD; Oellerich, M; Schütz, E; Shipkova, M; Wieland, E | 1 |
| Boerth, RC; Fillingim, E; Gremse, DA; Hoff, CJ; Wells, DJ | 1 |
| Ishida, Y; Keogh, A; Okamoto, M; Strain, A | 1 |
| Armstrong, VW; Oellerich, M; Schütz, E; Shipkova, M | 1 |
| Chamuleau, RA; Daalhuisen, J; Flendrig, LM; Jörning, GG; Ladiges, NC; Maas, MA; Sommeijer, D; Te Velde, AA | 1 |
| Kakiuchi, Y; Kihara, S; Kohda, Y; Miyabe, M; Sato, S; Takahashi, S; Toyooka, H | 1 |
| Flouvat, B; Laroche, N; Leneveu, A; Roux, A | 1 |
| Nacke, A; Reichel, C; Sauerbruch, T; Skodra, T; Spengler, U | 1 |
| Bass, S; Boyles, J; Carter, WG; Dirikolu, L; Harkins, JD; Karpiesiuk, W; Lehner, A; Mundy, GD; Rees, WA; Tobin, T; Woods, WE | 1 |
| Casagrande, F; Cobelli, C; Fabris, L; Jemmolo, RM; Lirussi, F; Okolicsanyi, L; Paleari, D; Rigon, M; Strazzabosco, M; Toffolo, G; Viaggi, S | 1 |
| Aita, P; Boiocchi, M; Cannizzaro, R; Colussi, AM; Corona, G; Robieux, I; Sorio, R; Toffoli, G; Tumolo, S | 1 |
| Isohanni, MH; Neuvonen, PJ; Olkkola, KT | 3 |
| Bartellini, M; Levi, D; Miguez, C; Muñoz, AE; Niselman, V; Podestá, A; Rubio, M; Terg, R | 1 |
| Bergslien, O; Dale, O; Rygnestad, T; Zahlsen, K | 1 |
| Jeyaraj, PR; Joseph, VT; Ong, HS; Soo, KC; Tan, SY | 1 |
| Ahmed, AM; Ahmed, HA; Armstrong, VW; El Desoky, ES; Nafeh, MA; Oellerich, M; Schütz, E | 1 |
| Botta, F; Celle, G; Ceppa, P; Fasoli, A; Giannini, E; Lantieri, PB; Risso, D; Testa, R | 1 |
| Kupcová, V; Schmidtová, K; Szántová, M; Turecký, L | 1 |
| Kupcová, V | 1 |
| Chen, HM; Lu, PP; Shyr, MH; Tan, PP | 1 |
| Kakiuchi, Y; Kohda, Y; Miyabe, M; Momose, Y | 1 |
| Chichester, C; McKindley, DS; Raymond, R | 1 |
| Backman, JT; Kivistö, KT; Neuvonen, PJ; Taavitsainen, P; Wang, JS; Wen, X | 1 |
| Fiegel, HC; Kaufmann, PM; Kluth, D; Kneser, U; Pollok, JM; Rogiers, X | 1 |
| Ono, T; Ozaki, M; Sakio, H; Sato, T; Yasuda, S | 1 |
| Büntemeyer, H; Duvar, S; Lehmann, J; Lünsdorf, H; Müthing, J; Strauss, M; Werner, A | 1 |
| Botta, F; Caglieris, S; Celle, G; Dardano, G; Fasoli, A; Giannini, E; Lantieri, PB; Risso, D; Testa, R; Valente, U | 1 |
| Bornscheuer, A; Heine, J; Herrmann, H; Höltje, M; Leuwer, M; Mahr, KH; Marx, G; Piepenbrock, S; Rueckoldt, H; Vangerow, B | 1 |
| Callivà, R; Cavallari, A; Cescon, M; Ercolani, G; Grazi, GL; Mazziotti, A; Pierangeli, F | 1 |
| Botta, F; Giannini, E; Romagnoli, P; Testa, R | 1 |
| Boldt, J; Hüttner, I; Kumle, B; Piper, SN; Schmidt, CC; Suttner, SW | 1 |
| Barreca, T; Botta, F; Cataldi, A; Fasoli, A; Franceschini, R; Giannini, E; Rolandi, E; Tenerelli, P; Testa, R | 1 |
| Artru, AA; Mautz, DS; Momota, Y; Powers, KM; Ueda, Y | 1 |
| Botta, F; Fasoli, A; Giannini, E; Risso, D; Romagnoli, P; Testa, R | 1 |
| Botta, F; Ceppa, P; Fasoli, A; Giannini, E; Risso, D; Romagnoli, P; Testa, R | 1 |
| Baker, AB; Gao, L; Ramzan, I | 1 |
| Bertoli, M; Calò, L; Floreani, M; Orlando, R; Padrini, R; Palatini, P; Piccoli, P | 1 |
| Rygnestad, T; Samdal, F | 1 |
| Inomata, S; Tanaka, E; Yasuhara, H | 1 |
| Azzena, G; Brogli, M; Galavotti, D; Morsiani, E; Pazzi, P; Puviani, AC; Tosatti, S; Valieri, L | 1 |
| Haertel, C; Lenhart, A; Meier-Hellmann, A; Michel, C; Rank, N; Spies, C; Welte, M | 1 |
| Armstrong, VW; Igonin, AA; Kukes, VG; Oellerich, M; Shipkova, M | 1 |
| Průsa, R; Sídlová, K | 1 |
| Bachmann, S; Dobis, C; Keck, H; Knoop, M; Meyer, A; Neuhaus, P | 1 |
| Armstrong, VW; Oellerich, M | 1 |
| Casparrini, G; Giuliani, M; Grossi, GB; Lajolo, C; Pileri, M | 1 |
| Asada, A; Kariya, N; Matsuura, Y; Nishi, S; Shimadzu, K | 1 |
| Botta, F; Ceppa, P; Fasoli, A; Giannini, E; Romagnoli, P; Testa, E; Testa, R | 1 |
| Boerth, RC; Gremse, DA; Hoff, CJ; Sindel, LJ; Wells, DJ | 1 |
| Biollaz, J; Buclin, T; Corpataux, JM; Mosimann, F; Munafo, A | 1 |
| Ishii, T; Kaneko, H; Katagiri, M; Maeda, T; Otsuka, Y; Shiba, T; Takagi, S; Tamura, A; Tsuchiya, M | 1 |
| Armstrong, VW; Niedmann, PD; Oellerich, M; Shipkova, M; Streit, F | 1 |
| Baba, Y; Inomata, S; Kakiuchi, Y; Kohda, Y; Miyabe, M; Nagashima, A; Nakayama, S; Okuyama, K; Tanaka, E; Toyooka, H; Yamasaki, Y | 1 |
| Rózański, J | 1 |
| Bellini, T; Brogli, M; Galavotti, D; Morsiani, E; Pazzi, P; Puviani, AC; Ricci, D | 1 |
| Borro, P; Botta, F; Chiarbonello, B; Fasoli, A; Fumagalli, A; Giannini, E; Malfatti, F; Polegato, S; Romagnoli, P; Savarino, V; Testa, E; Testa, R | 1 |
| Danhof, M; Groeneveld, AB; Swart, EL; Touw, DJ; van der Hoven, B | 1 |
| Boulet, J; Chichester, C; McKindley, DS; Sachdeva, K; Wang, P | 1 |
| Ali, MA; Chang, YJ; Rana, MW; Shapiro, MJ; Taylor, WH | 1 |
| Grzelak, I; Hevelke, P; Krawczyk, M; Kuczyńska, J; Pachecka, J; Paluszkiewicz, R; Pszenny, C; Tomaszewski, P; Zieniewicz, K | 1 |
| Chang, FY; Chiang, JH; Huang, YS; Lee, SD; Wu, JC | 1 |
| Alexson, SE; Diczfalusy, M; Halldin, M; Swedmark, S | 1 |
| Jakob, SM; Rosenberg, PH; Ruokonen, E; Takala, J | 1 |
| Apparaju, S; Desai, PB; Genter, MB | 1 |
| Becker, HD; Dauner, M; Doser, M; Linti, C; Planck, H; Schenk, M; Viebahn, R; Zipfel, A | 1 |
| Botta, F; Chiarbonello, B; Colla, G; Fasoli, A; Giannini, E; Malfatti, F; Risso, D; Romagnoli, P; Testa, E; Testa, R | 1 |
| Behrmann, C; Fleig, WE; Kleber, G; Meiss, F; Steudel, N; Sziegoleit, U; Zipprich, A | 1 |
| Breda, L; Brogli, M; Galavotti, D; Gambari, R; Guarniero, S; Mischiati, C; Morsiani, E; Puviani, AC; Ricci, D; Sereni, A | 1 |
| Baldassarre, M; Furlanut, M; Licari, M; Pea, F | 1 |
| Fukuda, T; Homma, M; Kakiuchi, Y; Kohda, Y; Miyabe, M; Toyooka, H | 1 |
| Blome, M; Boldt, J; Kumle, B; Lehmann, A; Piper, SN; Suttner, SW | 1 |
| Hashimoto, Y; Moriya, F; Nakanishi, A | 1 |
| Asada, A; Funao, T; Oda, Y; Tanaka, K | 1 |
| Hashimoto, Y; Moriya, F | 1 |
| De Martin, S; Floreani, M; Orlando, R; Padrini, R; Palatini, P; Piccoli, P | 1 |
| Fukuda, Y; Matsuyama, K; Miyake, H; Tashiro, S; Yogita, S | 1 |
| Armstrong, VW; Hein, OV; Kox, WJ; Oellerich, M; Ohring, R; Schilling, A; Spies, C | 1 |
| Kuczyñska, J; Pachecka, J; Piwowarska, J | 1 |
| Calmus, Y; Cherruau, B; Conti, F; Dousset, B; Guérin, C; Houssin, D; Soubrane, O | 1 |
| Armstrong, VW; Braun, JP; Buehner, S; Dohmen, P; Grosse, J; Konertz, W; Kox, WJ; Lochs, H; Moshirzadeh, M; Oellerich, M; Schlaefke, A; Schroeder, T; Spies, C; Streit, F | 1 |
| Berry, DP; Dennison, AR; Lloyd, TD; Orr, S | 1 |
| Armstrong, VW; Brown, SA; Kenkel, JM; Lipschitz, AH; Luby, M; Oellerich, M; Rohrich, RJ; Shepherd, G; Streit, F | 1 |
| Leopold, A; Moursi, AM; Weaver, JS; Wilson, S | 1 |
| Chen, MF; Lee, WC | 1 |
| Bagonluri, MT; Boison, JO; Reid, RS; Woodbury, MR | 1 |
| Bartges, J; Cox, SK; Hamner, T | 1 |
| Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E | 1 |
| Britto, MR; Mainka, MB; Parivar, K; Sarapa, N | 1 |
| Ilkiw, JE; Pypendop, BH | 1 |
| Ilkiw, JE; Pypendop, BH; Stanley, SD; Thomasy, SM | 1 |
| Ahonen, J; Isohanni, MH; Neuvonen, PJ; Olkkola, KT | 1 |
| Angelini, GD; Ascione, R; Cohen, A; Lovell, AT; Rajakaruna, C; Reeves, BC; Talpahewa, S | 1 |
| Addario, L; Ascione, A; De Luca, M; Di Costanzo, GG; Galeota Lanza, A; Giannelli, E; Lampasi, F; Macr, M; Picciotto, FP; Scaglione, G; Tartaglione, MT; Tritto, G; Utech, W | 1 |
| Jia, QB; Wang, WT; Wang, ZX; Yan, LN; Zhang, RM | 1 |
| Drozdzik, M; Gawronska-Szklarz, B; Loniewski, I; Musial, HD; Paprota, B | 1 |
| Kałdońska, M; Millo, B; Mokrzycka, M; Pawlik, A | 1 |
| Brennscheidt, U; Brunnmüller, U; Proppe, D; Seiler, KU; Thomann, P | 1 |
| Galle, PR; Kanzler, S; Teufel, A | 1 |
| Brown, KA; de Solis, CN; Dickey, EJ; McKenzie, HC | 1 |
| Ballesteros, S; García, M; Martínez, MA; Segura, LJ | 1 |
| Cavalli, Rde C; da Cunha, SP; Duarte, G; Duarte, Lde B; Lanchote, VL; Marques, MP; Moisés, EC | 1 |
| Cao, W; Dong, P; Meng, X; Ouyang, X; Wang, Z; Zhang, R; Zhao, H | 1 |
| Benfeldt, E; Hansen, SH; Kissmeyer, AM; Rist, GM; Rolsted, K | 1 |
| Baur, H; Grotz, MR; Hildebrand, F; Krettek, C; Mahlke, L; Pape, HC; Probst, C; van Griensven, M | 1 |
| Cavalli, RC; da Cunha, SP; Dantas Móises, EC; de Barros Duarte, L; Duarte, G; Lanchote, VL | 1 |
| Borneman, R; Brayfield, C; Gerlach, JC; Müller, C; Puhl, G; Schmelzer, E; Zeilinger, K | 1 |
| Liang, MZ; Nan, F; Qin, YP; Xiang, J; Yu, Q; Zhang, C | 1 |
| Aguillon, D; Basquin, C; Bellissant, E; Boudjema, K; Compagnon, P; Laviolle, B; Mallédant, Y; Morel, I; Seguin, P; Turmel, V | 1 |
| Aragón, C; Bauer, I; Brandenburger, T; Eulenburg, V; Hermanns, H; Jadasz, J; Kremer, D; Küry, P; Schlösser, L; Werdehausen, R | 1 |
| ter Weijden, E; van den Broek, MP; Ververs, FF | 1 |
| Barker, SA; Da Cunha, AF; Messenger, KM; Nevarez, JG; Queiroz-Williams, P; Stout, RW; Tully, TN | 1 |
| Brown, SA; Kenkel, JM; Oni, G | 1 |
| Armstrong, G; Beg, N; Hewitt, EA; Katz, S; Vancaillie, TG | 1 |
| Carrasco-Portugal, MC; Flores-Murrieta, FJ; González-Zamora, JF; Jiménez-Bravo, MA; Pérez-Guillé, BE; Soriano-Rosales, RE; Toledo-López, A; Villegas-Alvarez, F | 1 |
| Brown, S; Kenkel, J; Oni, G | 1 |
| Frenz, M; Neumann, S; Oellerich, M; Streit, F | 1 |
| Kenkel, J; Oni, G; Rasko, Y | 1 |
| Könitz, V; Meier, J; Paulke, A; Reyher, C; Toennes, SW; Wunder, C; Zacharowski, K | 1 |
| Di Salvo, A; Galarini, R; Giusepponi, D; Moretti, S; Saluti, G | 1 |
| Feng, YH; Gui, Y; Hu, XD; Liang, S; Liu, JB; Qian, LX; Qiu, LY; Zhai, L; Zu, Y | 1 |
| Kushner, H; Martell, B; Mayer, P; Mize, A; Richardson, E | 1 |
| de Rooster, H; Devriendt, N; Paepe, D; Serrano, G | 1 |
| Bailey, S; Dzikiti, BT; Escobar, A; Maney, JK; Thorogood, JC | 1 |
| Christians, U; Crouch, CE; Fernandez-Bustamante, A; Hendrickse, A; Henthorn, TK; Kaizer, AM; Schniedewind, B; Wilkey, BJ | 1 |
| Arthur, RM; Blea, J; Katzman, S; Knych, HK; McKemie, DS | 1 |
10 review(s) available for lidocaine and monoethylglycinexylidide
| Article | Year |
|---|---|
[Monoethylglycinexylidide (MEGX)-test. A test for the assessment of prognosis before and after liver transplantation].
Topics: Fluorescence Polarization Immunoassay; Hepatitis, Chronic; Humans; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests; Liver Transplantation; Prognosis | 1995 |
Noninvasive tests of CYP3A enzymes.
Topics: Animals; Breath Tests; Cytochrome P-450 Enzyme System; Dapsone; Erythromycin; Humans; Hydrocortisone; Lidocaine; Liver; Midazolam; Nifedipine | 1994 |
MEGX test in hepatology: the long-sought ultimate quantitative liver function test?
Topics: Humans; Lidocaine; Liver Function Tests; Metabolic Clearance Rate; Predictive Value of Tests | 1993 |
[Drugs predicting hepatic function].
Topics: Humans; Lidocaine; Liver; Liver Transplantation | 1993 |
The use of lidocaine as a test of liver function in liver transplantation.
Topics: Humans; Lidocaine; Liver Function Tests; Liver Transplantation | 1996 |
[Importance of determination of monoethylglycinexylidide (MEGX)--as a liver function test in hepatology and liver transplantation].
Topics: Animals; Humans; Lidocaine; Liver Diseases; Liver Function Tests; Liver Transplantation | 1999 |
Potential use of pharmacological markers to quantitatively assess liver function during liver transplantation surgery.
Topics: Adult; Antipyrine; Biomarkers; Breath Tests; Caffeine; Coloring Agents; Galactose; Humans; Indocyanine Green; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Postoperative Period; Reference Values | 2000 |
The clinical importance of conventional and quantitative liver function tests in liver transplantation.
Topics: Chlorzoxazone; Humans; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Midazolam | 2000 |
The MEGX test: a tool for the real-time assessment of hepatic function.
Topics: Anesthetics, Local; Animals; Dealkylation; Humans; Lidocaine; Liver Circulation; Liver Function Tests; Liver Transplantation | 2001 |
[Liver function test to predict hepatic failure after liver resection--expensive and without clinical relevance?].
Topics: Bilirubin; Disease Progression; Hepatectomy; Humans; Indocyanine Green; Lidocaine; Liver; Liver Cirrhosis; Liver Failure; Liver Function Tests; Liver Regeneration; Postoperative Complications; Predictive Value of Tests; Prognosis; Risk Factors; Tomography, Emission-Computed, Single-Photon | 2007 |
54 trial(s) available for lidocaine and monoethylglycinexylidide
| Article | Year |
|---|---|
Reliability of the MEGX test in the selection of liver grafts.
Topics: Adult; Female; Humans; Lidocaine; Liver Function Tests; Liver Transplantation; Male; Tissue Donors | 1991 |
Lack of acute effect on lidocaine pharmacokinetics from parenteral nutrition.
Topics: Adult; Amino Acids; Chromatography, High Pressure Liquid; Dialysis; Female; Humans; Lidocaine; Male; Parenteral Nutrition, Total | 1990 |
The pharmacokinetics and pharmacodynamics of lignocaine and MEGX in healthy subjects.
Topics: Adult; Blood Pressure; Double-Blind Method; Electrocardiography; Humans; Kinetics; Lidocaine; Male; Phonocardiography; Random Allocation | 1987 |
Effect of duration of lidocaine infusion and route of cimetidine administration on lidocaine pharmacokinetics.
Topics: Adult; Cimetidine; Dealkylation; Drug Interactions; Humans; Infusions, Intravenous; Kinetics; Lidocaine; Male | 1986 |
Lignocaine metabolite formation: an indicator for liver dysfunction and predictor of survival in surgical intensive care patients.
Topics: Aged; Bilirubin; Blood Pressure; Critical Care; Critical Illness; Female; Humans; Lidocaine; Liver; Liver Function Tests; Male; Middle Aged; Postoperative Care; Prognosis; Sensitivity and Specificity | 1995 |
Increasing splanchnic blood flow in the critically III.
Topics: Adult; Aged; Anesthetics, Local; Coloring Agents; Critical Illness; Dopamine; Dopamine Agonists; Gastric Mucosa; Hemodynamics; Humans; Hydrogen-Ion Concentration; Indocyanine Green; Lidocaine; Middle Aged; Multiple Organ Failure; Single-Blind Method; Splanchnic Circulation; Systemic Inflammatory Response Syndrome | 1995 |
Metabolic liver function and lipoprotein metabolism after orthotopic liver transplantation in patients on immunosuppressive therapy with FK 506 or cyclosporine.
Topics: Adolescent; Adult; Antilymphocyte Serum; Apolipoprotein A-I; Apolipoproteins B; Azathioprine; Bilirubin; Cholesterol; Cyclosporine; Drug Administration Schedule; Drug Therapy, Combination; Europe; Humans; Lidocaine; Liver Function Tests; Liver Transplantation; Methylprednisolone; Middle Aged; Prednisolone; Tacrolimus; Time Factors | 1995 |
Which lidocaine dose should be used for the MEGX liver function test?
Topics: Dose-Response Relationship, Drug; Double-Blind Method; Humans; Lidocaine; Liver Function Tests | 1995 |
The yin and yang of lidocaine and cyclosporine metabolism in liver graft recipients.
Topics: Cyclosporine; Drug Interactions; Humans; Lidocaine; Liver Transplantation; Metabolic Clearance Rate; Microsomes, Liver; Models, Theoretical; NADP; Prospective Studies | 1994 |
Monoethylglycinexylidide formation in compensated cirrhosis: correlation with Child-Pugh score.
Topics: Adult; Aged; Analysis of Variance; Contraindications; Female; Humans; Lidocaine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Regression Analysis | 1994 |
The effect of oral omeprazole on the disposition of lignocaine.
Topics: Administration, Oral; Adult; Double-Blind Method; Drug Interactions; Humans; Lidocaine; Male; Omeprazole | 1994 |
Serum lidocaine and MEGX concentrations after pharyngeal anesthesia for gastroscopy.
Topics: Adult; Age Factors; Anesthesia, Local; Female; Gastroscopy; Gels; Humans; Lidocaine; Male; Oropharynx; Time Factors | 1994 |
The effect of liver disease and food on plasma MEGX concentrations.
Topics: Adult; Aged; Aging; Eating; Female; Humans; Injections, Intravenous; Lidocaine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged | 1994 |
Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis.
Topics: Adult; Chronic Disease; Female; Follow-Up Studies; Galactose; Hepatitis; Humans; Indocyanine Green; Lidocaine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Prognosis; Prospective Studies; Prothrombin Time; Serum Albumin | 1993 |
Histological comparison of donor livers and lidocaine metabolism in the utilization of organs for liver transplantation.
Topics: Humans; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Organ Preservation; Survival Analysis; Tissue Donors | 1993 |
Liver function assessment by MEGX. Application to oncology.
Topics: Adult; Aged; Aged, 80 and over; Evaluation Studies as Topic; Female; Humans; Lidocaine; Liver; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Neoplasms | 1996 |
Assessment of metabolic liver function and hepatic blood flow during cardiopulmonary bypass.
Topics: Adult; Aged; Cardiopulmonary Bypass; Coronary Artery Bypass; Drug Monitoring; Humans; Indocyanine Green; Lidocaine; Liver; Liver Circulation; Male; Metabolic Clearance Rate; Middle Aged; Monitoring, Intraoperative; Prospective Studies; Sensitivity and Specificity; Time Factors | 1996 |
Lidocaine elimination and monoethylglycinexylidide formation in the dehydrated camel.
Topics: Anesthetics, Local; Animals; Biotransformation; Camelus; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dehydration; Female; Fluorescence Polarization; Injections, Intravenous; Lidocaine; Liver; Regional Blood Flow; Water Deprivation | 1995 |
[The peripheral blood lymphocyte subpopulations in chronic anti-HCV-positive liver disease: their significance and correlation with liver function].
Topics: Adult; Biopsy; Female; Hepatitis C; Hepatitis, Chronic; Humans; Lidocaine; Liver; Liver Cirrhosis; Lymphocyte Subsets; Male; Middle Aged | 1996 |
Liver function tests and lidocaine metabolism (MEGX test) during i.v. CMF therapy in breast cancer.
Topics: Adult; Aged; Anesthetics, Local; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Fluorouracil; Humans; Lidocaine; Liver Function Tests; Methotrexate; Middle Aged; Prospective Studies | 1996 |
The low-dose monoethylglycinexylidide test: assessment of liver function with fewer side effects.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Liver; Liver Cirrhosis; Liver Failure; Liver Function Tests; Male; Middle Aged; Predictive Value of Tests; Reference Values | 1997 |
Early assessment of transplanted liver function: lignocaine clearance test (MEGX).
Topics: Anesthetics, Local; Biotransformation; Double-Blind Method; Enzymes; Half-Life; Humans; Lidocaine; Liver Function Tests; Liver Transplantation; Middle Aged; Prothrombin Time; Treatment Outcome | 1997 |
Orthotopic liver transplantation with preservation of portocaval flow compared with venovenous bypass.
Topics: Adult; Hemodynamics; Humans; Lidocaine; Liver Function Tests; Liver Transplantation; Middle Aged; Portasystemic Shunt, Surgical; Prospective Studies | 1997 |
Acute cyclosporine toxicity after liver transplantation is predicted by the lidocaine monoethylglycinexylidide test in the donor.
Topics: Adolescent; Adult; Aged; Cyclosporine; Female; Humans; Kidney Diseases; Lidocaine; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Nervous System Diseases; Prognosis; Prospective Studies; Tissue Donors | 1997 |
Monoethyl glycine xylidide (MEGX) test evaluation in primary biliary cirrhosis: comparison with Mayo score.
Topics: Adult; Aged; Evaluation Studies as Topic; Female; Humans; Lidocaine; Liver Cirrhosis, Biliary; Liver Function Tests; Male; Middle Aged; Prognosis; Prospective Studies; Survival Rate | 1997 |
The plasma concentration of lidocaine's principal metabolite increases during continuous epidural anesthesia in infants and children.
Topics: Anesthesia, Epidural; Anesthetics, Local; Child, Preschool; Female; Humans; Infant; Lidocaine; Male | 1998 |
The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans.
Topics: Adult; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Lidocaine; Liver Function Tests; Male; Mixed Function Oxygenases; Reproducibility of Results; Rifampin | 1998 |
Effect of erythromycin and itraconazole on the pharmacokinetics of oral lignocaine.
Topics: Administration, Oral; Adult; Anesthetics, Local; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Double-Blind Method; Drug Interactions; Erythromycin; Female; Humans; Itraconazole; Lidocaine; Male; Mixed Function Oxygenases; Placebos; Protein Synthesis Inhibitors | 1999 |
Lidocaine and monoethylglycinexylidide serum determinations to analyze liver function of cirrhotic patients after oral administration.
Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Bilirubin; Female; Half-Life; Hepatitis A; Hepatitis B; Humans; Lidocaine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Partial Thromboplastin Time; Sensitivity and Specificity; Serum Albumin; Severity of Illness Index | 1999 |
Focus on mobilisation after lower abdominal surgery. A double-blind randomised comparison of epidural bupivacaine with morphine vs. lidocaine with morphine for postoperative analgesia.
Topics: Abdomen; Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Blood Pressure; Bupivacaine; Consciousness; Double-Blind Method; Female; Follow-Up Studies; Glycoproteins; Humans; Lidocaine; Locomotion; Male; Middle Aged; Morphine; Muscle, Skeletal; Pain, Postoperative; Respiration | 1999 |
Low-dose dopexamine in patients undergoing hemihepatectomy: an evaluation of effects on reduction of hepatic dysfunction and ischaemic liver injury.
Topics: Adult; Aged; Antithrombin III; Dopamine; Dopamine Agonists; Double-Blind Method; Female; Hemodynamics; Hepatectomy; Hepatic Veins; Humans; Lactic Acid; Lidocaine; Liver; Liver Function Tests; Male; Middle Aged; Oxygen; Oxyhemoglobins; Prospective Studies; Prothrombin; Reperfusion Injury; Transaminases; Vasodilator Agents | 2000 |
Low-flow desflurane and sevoflurane anesthesia minimally affect hepatic integrity and function in elderly patients.
Topics: Aged; Aged, 80 and over; Anesthetics, Inhalation; Desflurane; Female; Gastric Mucosa; Glutathione Transferase; Humans; Isoflurane; Lidocaine; Liver; Male; Methyl Ethers; Sevoflurane | 2000 |
N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study.
Topics: Acetylcysteine; Adult; Aged; Blood Flow Velocity; Coloring Agents; Double-Blind Method; Female; Free Radical Scavengers; Hemodynamics; Humans; Indocyanine Green; Infusions, Intravenous; Injections, Intravenous; Lidocaine; Liver; Liver Circulation; Liver Function Tests; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Oxygen Consumption; Prospective Studies; Shock, Septic; Survival Analysis | 2000 |
The monoethylglycinexylidide (MEGX) test as a marker of hepatic dysfunction in septic patients with pneumonia.
Topics: Adult; Aged; Biomarkers; Cytokines; Female; Humans; Lidocaine; Liver; Male; Middle Aged; Pneumonia; Sepsis | 2000 |
A preliminary evaluation of the discriminative power of the monoethylglycinexylidide formation test after intravenous and oral administration of lidocaine.
Topics: Administration, Oral; Area Under Curve; Diagnosis, Differential; Female; Half-Life; Humans; Infusions, Intravenous; Lidocaine; Liver Cirrhosis; Male; Reference Values; Statistics, Nonparametric | 2001 |
Plasma lidocaine concentrations during continuous thoracic epidural anesthesia after clonidine premedication in children.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Analgesics; Anesthesia, Epidural; Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Local; Child; Child, Preschool; Clonidine; Drug Interactions; Humans; Infant; Lidocaine; Male; Methyl Ethers; Preanesthetic Medication; Sevoflurane; Thoracic Vertebrae; Urologic Surgical Procedures | 2001 |
[The effect of hyperlipidemia on metabolism, distribution and secretion of lidocaine in patients with primary hyperlipidemia].
Topics: Adult; Area Under Curve; Body Mass Index; Half-Life; Humans; Hypercholesterolemia; Hyperlipidemias; Injections, Intravenous; Lidocaine; Lipoproteins, HDL; Middle Aged; Triglycerides | 2000 |
Endotoxic shock alters the pharmacokinetics of lidocaine and monoethylglycinexylidide.
Topics: Animals; Blood Pressure; Carboxylesterase; Carboxylic Ester Hydrolases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Hemodynamics; Lidocaine; Liver; Male; Mixed Function Oxygenases; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Shock, Septic | 2002 |
Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.
Topics: Anti-Arrhythmia Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP1A2 Inhibitors; Double-Blind Method; Fluvoxamine; Humans; Infusions, Intravenous; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index | 2004 |
Effect of itraconazole on the pharmacokinetics of inhaled lidocaine.
Topics: Administration, Inhalation; Adult; Anesthetics, Local; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Female; Humans; Itraconazole; Lidocaine; Male | 2004 |
The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor.
Topics: Adult; Aged; Area Under Curve; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Half-Life; Humans; Isoxazoles; Lidocaine; Liver Diseases; Male; Matched-Pair Analysis; Metabolic Clearance Rate; Middle Aged; Sulfonamides | 2005 |
Effect of ciprofloxin on the pharmacokinetics of intravenous lidocaine.
Topics: Adult; Anesthetics, Local; Anti-Infective Agents; Biotransformation; Ciprofloxacin; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Half-Life; Humans; Injections, Intravenous; Lidocaine; Male | 2005 |
Splanchnic organ injury during coronary surgery with or without cardiopulmonary bypass: a randomized, controlled trial.
Topics: Aged; Alanine Transaminase; Amylases; Aspartate Aminotransferases; Blood Glucose; Carbohydrates; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Female; Glucagon; Humans; Inactivation, Metabolic; Insulin; Intestinal Absorption; Intestinal Diseases; Intestine, Small; Ischemia; Lidocaine; Liver; Liver Diseases; Liver Function Tests; Male; Middle Aged; Pancreas; Pancreatic Diseases; Postoperative Complications; Risk; Splanchnic Circulation | 2006 |
Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.
Topics: Administration, Oral; Adult; Anesthetics, Local; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Erythromycin; Female; Fluvoxamine; Half-Life; Humans; Lidocaine; Male; Metabolic Clearance Rate; Nausea | 2006 |
Serum concentrations of lidocaine and its metabolites after prolonged infusion in healthy horses.
Topics: Anesthetics, Local; Animals; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Horses; Infusions, Parenteral; Lidocaine; Male; Safety; Time Factors | 2008 |
Pharmacokinetics of lidocaine and its metabolite in peridural anesthesia administered to pregnant women with gestational diabetes mellitus.
Topics: Adult; Anesthesia, Epidural; Anesthetics, Local; Area Under Curve; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Diabetes, Gestational; Female; Humans; Lidocaine; Metabolic Clearance Rate; Pregnancy; Time Factors; Young Adult | 2008 |
Is dopexamine superior to dopamine in the treatment of multiple trauma patients--a prospective, double-blind, randomised study.
Topics: Adolescent; Adult; Blood Pressure; Critical Care; Dopamine; Double-Blind Method; Female; Gastric Mucosa; Humans; Length of Stay; Lidocaine; Male; Middle Aged; Multiple Organ Failure; Multiple Trauma; Oxygen Consumption; Prospective Studies; Respiration, Artificial; Splanchnic Circulation; Trauma Severity Indices; Vasodilator Agents; Viscera; Wounds, Nonpenetrating; Young Adult | 2010 |
Distribution of bupivacaine enantiomers and lidocaine and its metabolite in the placental intervillous space and in the different maternal and fetal compartments in term pregnant women.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Bupivacaine; Chorionic Villi; Female; Humans; Lidocaine; Placenta; Pregnancy; Stereoisomerism; Tissue Distribution; Umbilical Arteries; Umbilical Veins; Young Adult | 2011 |
Effect of an anesthesia with propofol compared with desflurane on free radical production and liver function after partial hepatectomy.
Topics: Aged; Anesthetics, Inhalation; Desflurane; Female; Free Radicals; Hepatectomy; Humans; Isoflurane; Lidocaine; Liver; Liver Function Tests; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Propofol; Prospective Studies; Recovery of Function; Single-Blind Method; Treatment Outcome | 2012 |
Pharmacokinetics of lidocaine and its active metabolite monoethylglycinexylidide after a single intravenous administration in chickens (Gallus domesticus) anesthetized with isoflurane.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Local; Animals; Area Under Curve; Chickens; Female; Half-Life; Injections, Intravenous; Isoflurane; Lidocaine | 2012 |
Lignocaine plasma levels following topical gel application in laparoscopic and hysteroscopic procedures.
Topics: Administration, Topical; Algorithms; Anesthetics, Local; Area Under Curve; Calibration; Female; Gas Chromatography-Mass Spectrometry; Gels; Humans; Hysteroscopy; Laparoscopy; Lidocaine; Prospective Studies | 2012 |
Comparison of five commonly-available, lidocaine-containing topical anesthetics and their effect on serum levels of lidocaine and its metabolite monoethylglycinexylidide (MEGX).
Topics: Absorption; Adult; Anesthetics, Local; Female; Humans; Lidocaine; Male; Middle Aged; Nonprescription Drugs; Pharmaceutical Vehicles | 2012 |
Topical lidocaine enhanced by laser pretreatment: a safe and effective method of analgesia for facial rejuvenation.
Topics: Administration, Cutaneous; Analgesia; Analysis of Variance; Anesthetics, Combined; Anesthetics, Local; Benzocaine; Biotransformation; Cosmetic Techniques; Equipment Design; Facial Pain; Humans; Laser Therapy; Lasers, Gas; Lasers, Solid-State; Lidocaine; Ointments; Pain Measurement; Rejuvenation; Skin Absorption; Skin Aging; Surveys and Questionnaires; Tetracaine; Texas; Treatment Outcome | 2013 |
Pharmacokinetics of Lidocaine and Its Metabolites Following Vaginal Administration of Lidocaine Gel to Healthy Female Subjects.
Topics: Administration, Intravaginal; Adult; Anesthetics, Local; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Volunteers; Humans; Lidocaine; Young Adult | 2017 |
252 other study(ies) available for lidocaine and monoethylglycinexylidide
| Article | Year |
|---|---|
N-Hydroxyamide metabolites of lidocaine. Synthesis, characterization, quantitation, and mutagenic potential.
Topics: Animals; Carcinogens; Deuterium; Humans; Isotope Labeling; Lidocaine; Mass Spectrometry; Mice; Mutagens; Salmonella; Stereoisomerism | 1978 |
Lidocaine, monoethylglycinexylidide, and isolated human uterine muscle.
Topics: Adult; Depression, Chemical; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Lidocaine; Middle Aged; Pregnancy; Uterine Contraction | 1978 |
Pharmacokinetics and metabolism of lidocaine in patients with renal failure.
Topics: Computers; Ethylamines; Glycine; Half-Life; Humans; Kidney Failure, Chronic; Kinetics; Lidocaine; Xylenes | 1975 |
Gas chromatographic method for the quantitative determination of lidocaine and its metabolite monoethylglycinexylidide in plasma.
Topics: Chromatography, Gas; Lidocaine; Methods | 1976 |
Monoethylglycinexylidide production parallels changes in hepatic blood flow and oxygen delivery in lung injury managed with positive end-expiratory pressure.
Topics: Animals; Blood Flow Velocity; Critical Illness; Disease Models, Animal; Dogs; Evaluation Studies as Topic; Female; Hemodynamics; Injections, Intravenous; Lidocaine; Liver Circulation; Male; Oxygen Consumption; Positive-Pressure Respiration; Respiratory Distress Syndrome | 1992 |
MEGX as a test of donor liver function.
Topics: Adult; Child; Follow-Up Studies; Graft Survival; Humans; Lidocaine; Liver Function Tests; Liver Transplantation; Survival Analysis; Tissue Donors | 1992 |
The MEGX test as a measure of liver viability in an isolated liver perfusion circuit.
Topics: Animals; Cell Survival; Humans; In Vitro Techniques; Lidocaine; Liver; Liver Transplantation; Perfusion; Swine; Transplantation, Heterologous | 1992 |
Fluorescence polarization immunoassay and HPLC assays compared for measuring monoethylglycinexylidide in liver-transplant patients.
Topics: Bilirubin; Cholesterol; Chromatography, High Pressure Liquid; Fluorescence Polarization; Humans; Lidocaine; Liver Transplantation; Quality Control; Reference Values; Triglycerides | 1992 |
[Liver function tests in a clinical comparison].
Topics: Cholinesterases; Factor V; Factor VII; Galactose; Hepatic Encephalopathy; Humans; Indocyanine Green; Lidocaine; Liver Cirrhosis; Liver Function Tests; Metabolic Clearance Rate; Prealbumin; Prothrombin Time; Reference Values; Serum Albumin | 1992 |
Monoethylglycinexylide formation in assessing pediatric donor liver function.
Topics: Adult; Aging; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Child; Child, Preschool; Female; Humans; Infant; Lidocaine; Liver; Liver Function Tests; Male; Tissue Donors | 1992 |
Extrahepatic production of the lignocaine metabolite monoethylglycinexylidide (MEGX).
Topics: Adult; Female; Humans; Injections, Intravenous; Lidocaine; Liver; Liver Transplantation | 1992 |
A quick, sensitive high-performance liquid chromatography assay for monoethylglycinexylidide and lignocaine in serum/plasma using solid-phase extraction.
Topics: Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Humans; Lidocaine; Liver Transplantation; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Trimethoprim | 1992 |
Lignocaine metabolism and MEGX production in the liver transplant donor.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Biotransformation; Humans; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Tissue Donors | 1992 |
Improved measurement of MEGX in serum with the abbott TDx.
Topics: Humans; Lidocaine; Liver Transplantation; Reagent Kits, Diagnostic | 1992 |
Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophilic drugs.
Topics: Computer Simulation; Diffusion; Lidocaine; Liver; Mathematical Computing; Models, Biological; Perfusion; Pharmacokinetics; Propranolol; Taurocholic Acid; Tissue Distribution | 1992 |
Impaired hepatic metabolism of i.v. lignocaine as an index of cellular damage from carbon monoxide poisoning.
Topics: Adult; Carbon Monoxide Poisoning; Humans; Lidocaine; Liver; Male; Prognosis | 1992 |
Effect of acute and chronic moderate hypoxia on the kinetics of lidocaine and its metabolites and on regional blood flow.
Topics: Animals; Dogs; Hypoxia; Kinetics; Lidocaine; Regional Blood Flow | 1992 |
MEGX: from bench to bedside.
Topics: Humans; Indocyanine Green; Lidocaine; Liver Cirrhosis; Liver Function Tests; Liver Transplantation; Predictive Value of Tests; Survival Analysis | 1992 |
High-performance liquid chromatographic method for the simultaneous determination of monoethylglycinexylidide and lignocaine.
Topics: Chromatography, High Pressure Liquid; Humans; Lidocaine; Reference Standards; Spectrophotometry, Ultraviolet; Trimethoprim | 1992 |
Experimental studies of transient mass transfer and reaction in the liver: interpretation with a heterogeneous compartment model.
Topics: Animals; Extracellular Space; In Vitro Techniques; Lidocaine; Liver; Male; Mathematical Computing; Models, Biological; Pharmacokinetics; Rats; Rats, Inbred Strains | 1992 |
Quantitation of intrinsic drug-metabolizing capacity in human liver biopsy specimens: support for the intact-hepatocyte theory.
Topics: Adrenergic beta-Antagonists; Ethanolamines; Hepatitis, Chronic; Humans; Lidocaine; Liver; Liver Cirrhosis; Liver Diseases | 1991 |
Selective 3-hydroxylation deficiency of lidocaine and its metabolite in Dark Agouti rats.
Topics: Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Hydroxylation; Lidocaine; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains | 1991 |
Selection criteria for liver transplant donors.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Fluorescence Polarization Immunoassay; Humans; Infant; Lidocaine; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Tissue Donors | 1991 |
[Voltage-dependent effects of lidocaine and its metabolite, monoethylglycine xylidide (MEGX), on maximum rate of rise (Vmax) of action potential upstroke in guinea-pig papillary muscles].
Topics: Action Potentials; Animals; Female; Guinea Pigs; In Vitro Techniques; Lidocaine; Male; Papillary Muscles | 1991 |
Predictors of one-year pretransplant survival in patients with cirrhosis.
Topics: Humans; Indocyanine Green; Lidocaine; Liver Cirrhosis; Liver Function Tests; Liver Transplantation; Prospective Studies; Sensitivity and Specificity; Survival Analysis | 1991 |
The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation.
Topics: Biopsy; Fatty Liver; Humans; Lidocaine; Liver; Liver Transplantation; Postoperative Complications; Sterol O-Acyltransferase | 1991 |
Functional state of the donor liver and early outcome of transplantation.
Topics: Graft Survival; Humans; Lidocaine; Liver Diseases; Liver Function Tests; Liver Transplantation; Prognosis; Prospective Studies; Regression Analysis; Tissue Donors | 1991 |
[Serum concentration of lidocaine and its active metabolite monoethylglycinexylidine during fiberoptic bronchoscopy under local anesthesia].
Topics: Aerosols; Aged; Anesthetics, Local; Bronchoscopy; Female; Fiber Optic Technology; Humans; Lidocaine; Male; Middle Aged | 1991 |
Effects of controlled liver injury and ethanol pretreatment on monoethylglycine xylidide formation in the rat.
Topics: Animals; Body Weight; Caffeine; Diet; Ethanol; Half-Life; Hepatectomy; Indocyanine Green; Lidocaine; Liver; Male; Organ Size; Rats; Rats, Inbred Strains; Regression Analysis | 1991 |
Lidocaine absorption and metabolism after oropharyngeal application in young and young-elderly adults.
Topics: Absorption; Adult; Age Factors; Aged; Dosage Forms; Gels; Humans; Lidocaine; Middle Aged; Oropharynx; Sputum; Vocal Cords | 1991 |
[Effects of lidocaine and its metabolite, monoethylglycine xylidide (MEGX), on transmembrane action potentials in guinea-pig papillary muscles].
Topics: Action Potentials; Animals; Female; Guinea Pigs; Lidocaine; Muscles | 1990 |
Lidocaine metabolite formation as a measure of liver function in patients with cirrhosis.
Topics: Adult; Aged; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Prognosis; Prospective Studies; Time Factors | 1990 |
Quantification of three lidocaine metabolites and their conjugates.
Topics: Acetaminophen; Chemistry Techniques, Analytical; Drug Stability; Glucuronates; Glucuronidase; Humans; Hydrolysis; Lidocaine; Sulfates | 1990 |
Liver function assessment by drug metabolism.
Topics: Acetamides; Adult; Allopurinol; Aminopyrine; Caffeine; Half-Life; Humans; Indocyanine Green; Lidocaine; Liver; Liver Circulation; Liver Diseases; Liver Function Tests; Metabolic Clearance Rate; Middle Aged; Oxypurinol; Pyrimidines; Sorbitol | 1990 |
Assessment of liver function in the early postoperative period after liver transplantation with ICG, MEGX, and GAL tests.
Topics: Galactose; Humans; Indocyanine Green; Lidocaine; Liver Function Tests; Liver Transplantation; Postoperative Period | 1990 |
Assessment of lidocaine metabolite formation as a quantitative liver function test in children.
Topics: Adolescent; Bilirubin; Child; Child, Preschool; Chronic Disease; Fluoroimmunoassay; Humans; Infant; Lidocaine; Liver Diseases; Liver Function Tests; Prognosis; Prothrombin Time; Serum Albumin | 1990 |
[Pharmacokinetics of lidocaine and its metabolites in dog. Comparison between normal and CCl4-induced hepatic lesion].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Lidocaine | 1989 |
Lignocaine metabolite formation as a measure of pre-transplant liver function.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cytochrome P-450 Enzyme System; Evaluation Studies as Topic; Female; Graft Survival; Humans; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Preoperative Care; Prognosis; Prospective Studies; Time Factors | 1989 |
Inhibition of lignocaine metabolism by beta-adrenoceptor antagonists in rat and human liver microsomes.
Topics: Adrenergic beta-Antagonists; Animals; Dose-Response Relationship, Drug; Glutathione; Humans; Lidocaine; Microsomes, Liver; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Lidocaine treatment of painful diabetic neuropathy and endogenous opioid peptides in plasma.
Topics: Adult; beta-Endorphin; Diabetic Neuropathies; Dynorphins; Endorphins; Female; Humans; Lidocaine; Male; Middle Aged; Pain; Radioimmunoassay | 1989 |
Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Lidocaine; Microsomes, Liver; Molecular Structure | 1989 |
Metabolism of lidocaine by purified rat liver microsomal cytochrome P-450 isozymes.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hydroxylation; Isoenzymes; Lidocaine; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Lidocaine metabolism as an index of liver function in hepatic transplant donors and recipients.
Topics: Biopsy; Brain Death; Humans; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Tissue Donors | 1989 |
Donor rating in human liver transplantation: correlation of oxygen consumption after revascularization with MEGX formation in donors.
Topics: Humans; Lidocaine; Liver; Liver Circulation; Liver Function Tests; Liver Transplantation; Oxygen Consumption; Prognosis; Tissue Donors; Transplantation, Homologous | 1989 |
Therapeutic serum lidocaine and metabolite concentrations in patients undergoing electrophysiologic study after discontinuation of intravenous lidocaine infusion.
Topics: Aged; Anesthesia, Local; Arrhythmias, Cardiac; Electrophysiology; Female; Half-Life; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Time Factors | 1989 |
[Effect of dopamine on lidocaine metabolism in patients after partial liver resection--a pharmacokinetic analysis].
Topics: Dopamine; Humans; Lidocaine; Liver | 1989 |
Lidocaine and indocyanine green kinetics: effect of hypoxemia and/or hypercapnia.
Topics: Animals; Arteries; Carbon Dioxide; Hydrogen-Ion Concentration; Hypercapnia; Hypoxia; Indocyanine Green; Kinetics; Lidocaine; Male; Oxygen; Rabbits | 1987 |
[Pharmacokinetics of lidocaine and monoethylglycinexylidide after the intratracheal administration of lidocaine].
Topics: Anesthesia, Endotracheal; Humans; Lidocaine | 1988 |
Evaluation of quantitative liver function tests in liver donors.
Topics: Humans; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Prognosis; Prospective Studies; Tissue Donors | 1987 |
Monoethylglycinexylidide formation kinetics: a novel approach to assessment of liver function.
Topics: Chromatography, High Pressure Liquid; Fluorescence Polarization; Humans; Injections, Intravenous; Kinetics; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests; Statistics as Topic | 1987 |
[High-performance liquid chromatographic method for plasma or serum level monitoring of lidocaine and its active metabolites].
Topics: Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Lidocaine | 1986 |
Influence of hydralazine on the pharmacokinetics of orally administered d-propranolol and lidocaine in conscious dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Drug Combinations; Drug Interactions; Half-Life; Hydralazine; Lidocaine; Propranolol | 1987 |
An enzyme-distributed system for lidocaine metabolism in the perfused rat liver preparation.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; In Vitro Techniques; Kinetics; Lidocaine; Liver; Male; Models, Biological; Perfusion; Rats; Rats, Inbred Strains | 1986 |
Serum concentrations and urinary excretion of lidocaine and its two desethylated metabolites after spinal anaesthesia using lidocaine or lidocaine with phenylephrine.
Topics: Aged; Anesthesia, Spinal; Dealkylation; Humans; Injections, Spinal; Kinetics; Lidocaine; Male; Middle Aged; Phenylephrine; Time Factors | 1985 |
Lidocaine disposition in mother, fetus, and neonate after spinal anesthesia.
Topics: Adult; Anesthesia, Spinal; Female; Fetus; Humans; Infant, Newborn; Kinetics; Lidocaine; Pregnancy | 1986 |
Pharmacokinetics of endotracheally administered lidocaine.
Topics: Anesthesia, Endotracheal; Half-Life; Humans; Lidocaine; Middle Aged | 1986 |
Age-dependent lidocaine disposition in patients with acute myocardial infarction.
Topics: Adult; Age Factors; Aged; Body Weight; Chromatography, High Pressure Liquid; Female; Heart Failure; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Male; Middle Aged; Myocardial Infarction; Regression Analysis | 1985 |
Lidocaine plasma concentrations following administration of intraoral lidocaine solution.
Topics: Absorption; Chromatography, Gas; Half-Life; Humans; Kinetics; Lidocaine; Male; Mouth Mucosa; Random Allocation | 1985 |
Plasma concentrations of lidocaine and its principal metabolites during intermittent epidural anesthesia.
Topics: Adult; Anesthesia, Epidural; Castration; Chromatography, High Pressure Liquid; Drug Administration Schedule; Female; Humans; Hysterectomy; Kinetics; Lidocaine; Middle Aged; Models, Biological | 1985 |
Concentrations of lidocaine and monoethylglycylxylidide (MEGX) in lidocaine associated deaths.
Topics: Autopsy; Humans; Lidocaine; Tissue Distribution | 1985 |
The acute antiarrhythmic and toxic effects in mice and dogs of 2-ethylamino-2',6-'acetoxylidine (L-86), a metabolite of lidocaine.
Topics: Acetanilides; Administration, Oral; Animals; Arrhythmias, Cardiac; Blood Pressure; Chloroform; Dogs; Electrocardiography; Ethylamines; Female; Lethal Dose 50; Lidocaine; Male; Mice; Mice, Inbred Strains; Respiratory Insufficiency; Seizures; Vomiting; Xylenes | 1971 |
Simultaneous determination of lidocaine and its principal metabolites by liquid chromatography on silica gel, with aqueous eluent.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Fluorescence Polarization; Humans; Immunologic Techniques; Kinetics; Lidocaine | 1984 |
Lipid solubility modulates pH potentiation of local anesthetic block of Vmax reactivation in guinea pig myocardium.
Topics: Action Potentials; Anesthetics, Local; Animals; Electrophysiology; Guinea Pigs; Heart; Hydrogen-Ion Concentration; Kinetics; Lidocaine; Lipids; Membrane Potentials; Octanols; Solubility; Water | 1984 |
Simultaneous determination of lidocaine and its metabolites in plasma and myocardium.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Dogs; Female; Lidocaine; Male; Myocardium; Oxidation-Reduction | 1984 |
Penetration of lidocaine and its active desethylated metabolite into cerebrospinal fluid in man.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Kinetics; Lidocaine; Male | 1983 |
Determination of lidocaine and active metabolites in blood serum by liquid chromatography with electrochemical detection.
Topics: Bupivacaine; Chromatography, Liquid; Electrochemistry; Humans; Lidocaine; Time Factors | 1984 |
Simultaneous determination of lidocaine and its deethylated metabolites using gas-liquid chromatography with nitrogen-phosphorus detection.
Topics: Chromatography, Gas; Humans; Kinetics; Lidocaine; Male; Nitrogen; Phosphorus | 1984 |
Maternal, fetal, and neonatal lidocaine levels following local perineal infiltration.
Topics: Adolescent; Adult; Female; Fetal Blood; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Kinetics; Lidocaine; Male; Maternal-Fetal Exchange; Pregnancy | 1984 |
Antithrombotic effects of lidocaine and related compounds on laser-induced microvascular injury.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cricetinae; Female; Lasers; Lidocaine; Microcirculation; Thrombosis; Tocainide | 1981 |
Plasma levels, protein binding, and elimination data of lidocaine and active metabolites in cardiac patients of various ages.
Topics: Aged; Aging; Aspartate Aminotransferases; Bilirubin; Biotransformation; Blood Proteins; Creatinine; Female; Heart Diseases; Humans; Kinetics; Lidocaine; Male; Middle Aged; Protein Binding | 1983 |
Time-dependent kinetics of lignocaine in the isolated perfused rat liver.
Topics: Animals; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Lidocaine; Liver; Male; Perfusion; Rats; Rats, Inbred Strains; Sex Factors; Time Factors | 1983 |
A single-step assay for lidocaine and its major metabolite, monoethylglycinexylidide, in plasma by gas-liquid chromatography and nitrogen phosphorus detection.
Topics: Chromatography, Gas; Humans; Kinetics; Lidocaine; Nitrogen; Phosphorus | 1982 |
Excessive serum lidocaine levels during maintenance infusions: mechanisms and prevention.
Topics: Aged; Arrhythmias, Cardiac; Body Weight; Chromatography, Gas; Disease Susceptibility; Heart Arrest; Heart Failure; Hemodynamics; Humans; Hypotension; Infusions, Parenteral; Lidocaine; Liver Diseases; Metabolic Clearance Rate; Middle Aged; Myocardial Infarction; Time Factors | 1982 |
Plasma concentrations of lignocaine and its metabolites during fibreoptic bronchoscopy.
Topics: Aged; Bronchoscopy; Fiber Optic Technology; Humans; Lidocaine; Middle Aged; Time Factors | 1982 |
Prolonged seizures associated with the use of viscous lidocaine.
Topics: Absorption; Administration, Oral; Child, Preschool; Female; Humans; Infant; Lidocaine; Male; Seizures | 1982 |
Saliva concentrations of lidocaine and its metabolites in man.
Topics: Biotransformation; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Lidocaine; Saliva | 1982 |
Pharmacokinetics of lidocaine and its deethylated metabolite: dose and time dependency studies in man.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Kinetics; Lidocaine; Male; Time Factors | 1982 |
A rapid analytical procedure for the determination of concentrations of lidocaine and its two active metabolites in canine serum.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Lidocaine | 1982 |
Pharmacokinetic principles of lidocaine dosing in relation to disease state.
Topics: Adult; Age Factors; Aged; Animals; Dogs; Drug Therapy, Combination; Half-Life; Heart Failure; Humans; Kidney Diseases; Kinetics; Lidocaine; Liver Diseases; Metabolic Clearance Rate; Middle Aged; Time Factors | 1981 |
Modifications by lidocaine and its N-dealkylated metabolites of the response of the isolated rabbit aorta to transmural electrical stimulation.
Topics: Alkylation; Animals; Aorta, Thoracic; Bretylium Compounds; Calcium; Cocaine; Electric Stimulation; Lidocaine; Male; Muscle Contraction; Norepinephrine; Phentolamine; Potassium; Rabbits | 1980 |
[Lidocaine elimination and MEGX formation after oral lidocaine administration--a practicable test for assessment of quantitative liver function].
Topics: Administration, Oral; Humans; Lidocaine; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Metabolic Clearance Rate; Reference Values | 1993 |
Importance of cytochrome P-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients.
Topics: Aryl Hydrocarbon Hydroxylases; Breath Tests; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Lidocaine; Liver Transplantation; Male; Oxidoreductases, N-Demethylating; Predictive Value of Tests; Regression Analysis; Tacrolimus | 1994 |
Relationship of apolipoproteins AI, B and lipoprotein Lp(a) to hepatic function of liver recipients during the early post-transplant period.
Topics: Adult; Alanine Transaminase; Apolipoprotein A-I; Apolipoproteins B; Aspartate Aminotransferases; Biomarkers; Cholesterol; Female; Humans; Lidocaine; Lipoprotein(a); Liver Function Tests; Liver Transplantation; Male; Middle Aged; Postoperative Period; Time Factors | 1995 |
Hepatic lidocaine metabolism in chronic hepatitis C virus hepatitis with or without steatosis.
Topics: Adult; Aged; Fatty Liver; Female; Hepatitis C; Humans; Lidocaine; Liver; Male; Middle Aged | 1995 |
Monoethylglycinexylidide as an early predictor of posttraumatic multiple organ failure.
Topics: Adult; Aged; Bilirubin; Diagnosis, Differential; Female; Humans; Lidocaine; Liver Function Tests; Male; Middle Aged; Multiple Organ Failure; Prognosis; Prospective Studies; ROC Curve; Sensitivity and Specificity; Time Factors; Wounds and Injuries | 1995 |
The monoethylglycinexylidide test is more useful for evaluating liver function than indocyanine green test: case of a patient with remarkably decreased indocyanine green half-life.
Topics: Humans; Indocyanine Green; Lidocaine; Liver; Liver Function Tests; Male; Middle Aged | 1995 |
Rifampicin induction of lidocaine metabolism in cultured human hepatocytes.
Topics: Aged; Cells, Cultured; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Lidocaine; Liver; Male; Middle Aged; Rifampin | 1995 |
Monoethylglycinexylidide formation as an independent measure of warm hepatic ischemia and reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Hot Temperature; Lidocaine; Liver; Liver Diseases; Male; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Transaminases | 1995 |
CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients.
Topics: Administration, Oral; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Capsules; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Epilepsy; Female; Humans; Injections, Intravenous; Isoenzymes; Kidney Diseases; Kidney Function Tests; Lidocaine; Liver; Liver Diseases, Alcoholic; Liver Function Tests; Male; Middle Aged; Mixed Function Oxygenases; Peptide Fragments; Procollagen; Umbelliferones | 1995 |
Hepatic lidocaine metabolism and liver histology.
Topics: Humans; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests; Sensitivity and Specificity | 1995 |
Quantitative liver testing with MEG-X: more optimism?
Topics: Autoimmune Diseases; Biopsy; Hepatitis; Hepatitis C; Lidocaine; Liver; Reproducibility of Results | 1995 |
A technique for porcine hepatocyte harvest and description of differentiated metabolic functions in static culture.
Topics: Animals; Biotransformation; Cell Separation; Cell Survival; Lidocaine; Liver; Male; Oxygen Consumption; Swine | 1995 |
Effect of dehydration and hyperosmolal hydration on lignocaine and metabolites disposition in conscious rabbits.
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Dehydration; Dinoprostone; Lidocaine; Male; Osmolar Concentration; Plasma Volume; Rabbits; Renin | 1994 |
MEGX (monoethylglycinexylidide): a novel in vivo test to measure early hepatic dysfunction after hypovolemic shock.
Topics: Animals; Biotransformation; Ischemia; Lidocaine; Liver; Liver Function Tests; Male; Microsomes, Liver; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Shock | 1995 |
Rapid simultaneous determination of lidocaine, bupivacaine, and their two main metabolites using capillary gas-liquid chromatography with nitrogen phosphorus detector.
Topics: Bupivacaine; Chromatography, Gas; Humans; Lidocaine; Nitrogen; Phosphorus; Reproducibility of Results | 1994 |
Effect of cyclosporine-A pretreatment on lidocaine metabolite formation in the regenerating rat liver.
Topics: Animals; Cyclosporine; Hepatectomy; Lidocaine; Liver; Liver Regeneration; Male; Organ Size; Rats; Rats, Inbred Lew; Reference Values | 1994 |
Monoethylglycinexylidide production as a measure in predicting hepatic histology.
Topics: Adult; Biomarkers; Female; Hepatitis, Chronic; Humans; Injections, Intravenous; Lidocaine; Liver Cirrhosis; Male; Middle Aged; Predictive Value of Tests; Severity of Illness Index; Time Factors | 1994 |
Enhancement of cytochrome P450 function of collagen-entrapped hepatocytes by the addition of liver extracellular matrix components.
Topics: Animals; Cells, Cultured; Collagen; Cytochrome P-450 Enzyme System; Drug Combinations; Extracellular Matrix; Laminin; Lidocaine; Liver; Proteoglycans; Rats | 1994 |
Early predictive markers of irreversible graft dysfunction after liver transplantation.
Topics: Actuarial Analysis; Adult; Aspartate Aminotransferases; Biomarkers; Factor V; Female; Graft Survival; Humans; Lidocaine; Liver Transplantation; Male; Middle Aged; Predictive Value of Tests; Retrospective Studies; Sensitivity and Specificity; Treatment Failure | 1994 |
Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver.
Topics: Albumins; Animals; Artificial Organs; Biotransformation; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Glucose; Lactates; Lactic Acid; Lidocaine; Liver; Male; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Time Factors; Urea | 1994 |
Current status in liver function tests: technical considerations.
Topics: Humans; Indocyanine Green; Lidocaine; Liver Function Tests | 1994 |
Monoethylglicinexylidide test: a prognostic indicator of survival in cirrhosis.
Topics: Adult; Female; Follow-Up Studies; Humans; Lidocaine; Life Tables; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Sensitivity and Specificity; Survival Rate | 1994 |
Omeprazole decreased formation of monoethylglycinexylidide in a patient with chronic active hepatitis.
Topics: Adult; Esophagitis, Peptic; Hepatitis C; Hepatitis, Chronic; Humans; Lidocaine; Male; Mixed Function Oxygenases; Omeprazole | 1994 |
The value of the donor MEGX test in predicting liver allograft recipient outcome.
Topics: Adolescent; Adult; Child; Child, Preschool; Graft Rejection; Humans; Infant; Lidocaine; Liver Function Tests; Liver Transplantation; Middle Aged; Predictive Value of Tests; Tissue Donors; Transplantation, Homologous; Treatment Outcome | 1994 |
Influence of gender on the monoethylglycinexylidide test in normal subjects and liver donors.
Topics: Adult; Contraceptives, Oral, Hormonal; Female; Humans; Lidocaine; Liver; Liver Transplantation; Male; Middle Aged; Sex Characteristics; Smoking; Tissue Donors | 1994 |
Lignocaine gel used for lubrication of intranasal and endotracheal tubes in premature neonates.
Topics: Female; Gels; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intubation; Intubation, Intratracheal; Lidocaine; Lubrication; Male; Positive-Pressure Respiration; Prospective Studies | 1994 |
Hepatic lidocaine metabolism and liver histology in patients with chronic hepatitis and cirrhosis.
Topics: Adult; Aged; Alanine Transaminase; Chronic Disease; Female; Hepatitis; Humans; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Sensitivity and Specificity | 1994 |
The role of dynamic and morphological studies in the assessment of potential liver donors.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Child; Child, Preschool; Female; Graft Rejection; Humans; Infant; Lidocaine; Liver; Liver Transplantation; Male; Middle Aged; Prospective Studies; Tissue Donors | 1994 |
Donor hyaluronic acid and MEGX levels do not accurately predict posttransplant liver function.
Topics: Evaluation Studies as Topic; Humans; Hyaluronic Acid; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Organ Preservation; Tissue Donors | 1993 |
Evaluation of the liver function of cirrhotic patients based on the formation of monoethylglycine xylidide (MEGX) from lidocaine.
Topics: Adult; Aged; Evaluation Studies as Topic; Female; Fluorescence Polarization Immunoassay; Humans; Lidocaine; Liver; Liver Cirrhosis, Alcoholic; Liver Cirrhosis, Biliary; Liver Function Tests; Male; Middle Aged; Portasystemic Shunt, Surgical; Sclerotherapy | 1993 |
Monoethylglycinexylidide clearance test: its role as a part of brain-dead donors' evaluation for liver transplantation.
Topics: Brain Death; Humans; Lidocaine; Liver Transplantation; Metabolic Clearance Rate; Prognosis; Tissue Donors | 1993 |
Use of monoethylglycinexylidide as a liver function test in the liver transplant recipient.
Topics: Adolescent; Adult; Aged; Bilirubin; Female; Humans; Lidocaine; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Time Factors | 1993 |
Assessment of lidocaine metabolite formation in comparison with other quantitative liver function tests.
Topics: Adolescent; Adult; Aminopyrine; Breath Tests; Child; Galactose; Humans; Lidocaine; Liver Diseases; Liver Function Tests | 1993 |
Lidocaine metabolite formation as a measure of perioperative liver function.
Topics: Adult; Aged; Alanine Transaminase; Antithrombin III; Aspartate Aminotransferases; Bilirubin; Female; Humans; Indocyanine Green; Injections, Intravenous; Lidocaine; Liver; Liver Function Tests; Male; Middle Aged; Postoperative Care; Preoperative Care | 1993 |
The unreliability of the lidocaine/monoethylglycinexylidide test for assessment of liver donors.
Topics: Adult; Aged; Child; Child, Preschool; Graft Survival; Humans; Infant; Lidocaine; Liver; Liver Transplantation; Middle Aged; Prognosis; Reproducibility of Results; Retrospective Studies; Tissue Donors | 1993 |
Excretion of lignocaine and its metabolite monoethylglycinexylidide in breast milk following its use in a dental procedure. A case report.
Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Female; Humans; Lidocaine; Milk, Human; Time Factors | 1993 |
Lignocaine metabolism and liver function testing in primary graft failure following orthotopic liver transplantation.
Topics: Female; Graft Rejection; Humans; Lidocaine; Liver Diseases; Liver Function Tests; Liver Transplantation; Middle Aged | 1993 |
[Evaluation of lidocaine metabolite (monoethylglycinexylidide) as a liver function test].
Topics: Evaluation Studies as Topic; Female; Fluorescence Polarization Immunoassay; Humans; Lidocaine; Liver Diseases; Liver Function Tests; Male; Middle Aged | 1993 |
Hepatic lidocaine metabolism is useful in the selection of patients in need of liver transplantation.
Topics: Hepatitis; Humans; Lidocaine; Liver; Liver Cirrhosis; Liver Diseases; Liver Transplantation | 1993 |
Assessment of prognosis in transplant candidates by use of the Pugh-MEGX score.
Topics: Adult; Female; Humans; Lidocaine; Life Tables; Liver Cirrhosis; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Probability; Prognosis; Proportional Hazards Models; Survival Analysis | 1993 |
Limits of the MEGX test in the selection of liver grafts for transplantation.
Topics: Adenosine; Adult; Allopurinol; Female; Glutathione; Graft Survival; Humans; Insulin; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Male; Organ Preservation; Organ Preservation Solutions; Prognosis; Raffinose; Solutions; Tissue Donors; Treatment Outcome | 1993 |
Safe use of liver donors with MEGX values less than 90 ng/mL.
Topics: Adenosine; Adult; Alanine Transaminase; Allopurinol; Analysis of Variance; Aspartate Aminotransferases; Female; Glutathione; Humans; Insulin; Lidocaine; Liver Function Tests; Liver Transplantation; Male; Organ Preservation; Organ Preservation Solutions; Prothrombin Time; Raffinose; Solutions; Tissue Donors | 1993 |
Hepatic lidocaine metabolism and complications of cirrhosis. Implications for assessing patient priority for hepatic transplantation.
Topics: Adult; Aged; Contraindications; Humans; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests; Liver Transplantation; Middle Aged; Risk Factors; Time Factors | 1993 |
Effect of hypoxia on the hepatic metabolism of lidocaine in the isolated perfused pig liver.
Topics: Analysis of Variance; Animals; Energy Metabolism; Hypoxia; In Vitro Techniques; Kinetics; Lidocaine; Liver; Liver Function Tests; Male; Metabolic Clearance Rate; Perfusion; Swine; Time Factors | 1993 |
Comprehensive evaluation of brain-dead donors for liver transplantation: personal experience.
Topics: Brain Death; Humans; Kidney Transplantation; Lidocaine; Liver Transplantation; Tissue Donors | 1993 |
Lidocaine metabolite formation in the liver donor as a predictive test for the safe and efficient introduction of cyclosporine in the recipient.
Topics: Adolescent; Adult; Aged; Brain Death; Child; Cyclosporine; Cytochrome P-450 Enzyme System; Female; Humans; Isoenzymes; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Prognosis; Tissue Donors | 1993 |
Pharmacokinetics of vinorelbine in patients with liver metastases.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Female; Half-Life; Humans; Lidocaine; Liver Function Tests; Liver Neoplasms; Middle Aged; Vinblastine; Vinorelbine | 1996 |
Changes in the metabolism of three model substrates catalysed by different P450 isozymes when administered as a cocktail to the carbon tetrachloride-intoxicated rat.
Topics: Animals; Biotransformation; Caffeine; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Hydantoins; Injections, Intravenous; Isoenzymes; Lidocaine; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Theophylline | 1995 |
Preliminary assessment of glycine conjugation of para-aminobenzoic acid as a quantitative test of liver function.
Topics: 4-Aminobenzoic Acid; Adolescent; Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Child; Child, Preschool; Female; Glycine; Hippurates; Humans; Lidocaine; Liver Diseases; Liver Function Tests; Male; Middle Aged; Prothrombin Time | 1995 |
Sensitive HPLC for simultaneous quantification of lidocaine and its metabolites monoethylglycinexylidide and glycinexylidide in serum.
Topics: Chromatography, High Pressure Liquid; Humans; Lidocaine; Liver Function Tests; Sensitivity and Specificity | 1996 |
Long-term hepatic regeneration and function in infants and children following liver resection.
Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Hepatectomy; Humans; Infant; Lidocaine; Liver; Liver Function Tests; Liver Neoplasms; Liver Regeneration; Magnetic Resonance Imaging; Male; Retrospective Studies | 1996 |
Lignocaine metabolism as an assessment of liver dysfunction.
Topics: Critical Care; Humans; Lidocaine; Liver Function Tests; Sensitivity and Specificity | 1996 |
Effect of moderate or severe liver dysfunction on the pharmacokinetics of gamma-hydroxybutyric acid.
Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Humans; Hydroxybutyrates; Lidocaine; Liver Cirrhosis; Male; Middle Aged | 1996 |
First-pass metabolism of lidocaine in the anesthetized rabbit. Contribution of the small intestine.
Topics: Anesthesia; Animals; Aorta, Thoracic; Biotransformation; Epithelium; Injections, Intravenous; Intestine, Small; Jugular Veins; Lidocaine; Liver; Lung; Male; Mesenteric Veins; Rabbits | 1996 |
Evaluation of liver function tests to predict operative risk in liver surgery.
Topics: Galactose; Humans; Indocyanine Green; Lidocaine; Liver Diseases; Liver Failure; Liver Function Tests; Postoperative Complications; Predictive Value of Tests; Risk Factors | 1995 |
Use of hepatic lidocaine metabolism to monitor patients with chronic liver disease.
Topics: Anesthetics, Local; Chronic Disease; Genetic Variation; Humans; Infusions, Intravenous; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests | 1996 |
Prognostic value of the monoethylglycinexylidide test in pediatric liver transplant candidates.
Topics: Adolescent; Child; Child, Preschool; Chronic Disease; Female; Humans; Infant; Lidocaine; Liver Failure; Liver Function Tests; Liver Transplantation; Male; Prognosis; Prospective Studies; Sensitivity and Specificity; Survival Analysis | 1996 |
The use of the lidocaine-monoethylglycinexylidide test in the liver transplant recipient.
Topics: Adolescent; Adult; Aged; Female; Hepatic Artery; Humans; Lidocaine; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Prognosis; Survival Analysis; Thrombosis | 1996 |
Prognostic value of the monoethylglycinexylidide liver function test in assessing donor liver suitability.
Topics: Humans; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Tissue Donors | 1996 |
The value of serial determination of MEGX and hyaluronic acid early after orthotopic liver transplantation.
Topics: Adolescent; Adult; Graft Rejection; Graft Survival; Humans; Hyaluronic Acid; Lidocaine; Liver Transplantation; Middle Aged; Receptors, Interleukin-2 | 1996 |
Identification of 2,6-xylidine as a major lidocaine metabolite in human liver slices.
Topics: Aniline Compounds; Biotransformation; Gas Chromatography-Mass Spectrometry; Humans; Lidocaine; Models, Chemical | 1996 |
Liver function and splanchnic ischemia in critically ill patients.
Topics: Critical Illness; Gastric Mucosa; Hemodynamics; Humans; Hydrogen-Ion Concentration; Indocyanine Green; Ischemia; Lidocaine; Liver; Liver Function Tests; Prospective Studies; Splanchnic Circulation | 1997 |
Value of an extended monoethylglycinexylidide formation test and other dynamic liver function tests in liver transplant donors.
Topics: Adult; Female; Humans; Lidocaine; Liver Function Tests; Liver Transplantation; Male; Tissue Donors | 1997 |
[Multiple organ failure after severe trauma: predictable by the MEGX liver function test?].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Critical Care; Humans; Injury Severity Score; Lidocaine; Liver Function Tests; Multiple Organ Failure; Multiple Trauma | 1996 |
Conventional and quantitative liver function tests after hepatic transplantation: a prospective long-term follow-up.
Topics: Adult; Bilirubin; Humans; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Metabolic Clearance Rate; Middle Aged; Prospective Studies; Time Factors | 1997 |
Effect of phenobarbital on the pharmacokinetics of lidocaine, monoethylglycinexylidide and 3-hydroxylidocaine in the rat: correlation with P450 isoform levels.
Topics: Anesthetics, Local; Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hypnotics and Sedatives; Isoenzymes; Lidocaine; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley | 1997 |
Determination of MEGX by HPLC with fluorescence detection.
Topics: 4-Chloro-7-nitrobenzofurazan; Chromatography, High Pressure Liquid; Fluorescence Polarization Immunoassay; Fluorescent Dyes; Fluorometry; Humans; Lidocaine; Reagent Kits, Diagnostic; Sensitivity and Specificity | 1997 |
Isolation of human hepatocytes from livers rejected for whole organ transplantation.
Topics: Cell Culture Techniques; Cell Separation; Cells, Cultured; Diazepam; Humans; Lidocaine; Liver; Liver Transplantation; Middle Aged; Patient Selection; Perfusion; Tissue Donors | 1997 |
Value of the in vitro or in vivo monoethylglycinexylidide test for predicting liver graft function.
Topics: Adenosine; Allopurinol; Glutathione; Humans; Insulin; Lidocaine; Liver Transplantation; Organ Preservation; Organ Preservation Solutions; Raffinose; Tissue Donors | 1997 |
The effect of age on plasma MEGX concentrations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Fluorescence Polarization Immunoassay; Humans; Lidocaine; Male; Middle Aged; Reference Values; Reproducibility of Results | 1997 |
Assessment of monoethylglycinexylidide as measure of liver function for patients with chronic viral hepatitis.
Topics: Adult; Biopsy; Chronic Disease; Female; Hepatitis, Viral, Human; Humans; Lidocaine; Liver; Liver Function Tests; Male; Middle Aged | 1997 |
The lidocaine monoethylglycinexylidide test of liver function.
Topics: Humans; Lidocaine; Liver Function Tests; Liver Transplantation; Monitoring, Physiologic; Prognosis; Tissue Donors | 1996 |
The monoethylglycinexylidide test does not correctly evaluate lidocaine metabolism after ischemic liver injury in the rat.
Topics: Animals; Bilirubin; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzymes; Fluorescence Polarization Immunoassay; Ischemia; Lidocaine; Liver; Liver Circulation; Male; Rats; Rats, Wistar; Reperfusion Injury; Sensitivity and Specificity | 1997 |
Toxicity of lidocaine desethyl metabolites.
Topics: Administration, Topical; Anesthetics, Local; Humans; Lidocaine | 1997 |
Monoethylglycinexylidide formation measurement as a hepatic function test to assess severity of chronic liver disease.
Topics: Adolescent; Adult; Age Factors; Aged; Anesthetics, Local; Case-Control Studies; Diagnosis, Differential; Female; Hepatitis, Chronic; Humans; Lidocaine; Liver; Liver Cirrhosis; Male; Microsomes, Liver; Middle Aged; Safety; Severity of Illness Index; Sex Factors; Time Factors | 1997 |
Value of MEGX test in predicting survival after liver transplantation from non-heart-beating donor pigs.
Topics: Adenosine; Allopurinol; Animals; Glutathione; Graft Survival; Heart Arrest; Insulin; Lidocaine; Liver; Liver Transplantation; Organ Preservation; Organ Preservation Solutions; Raffinose; Survival Rate; Swine; Tissue Donors | 1997 |
Serum concentrations of lignocaine and its metabolite monoethylglycinexylidide during fibre-optic bronchoscopy in local anaesthesia.
Topics: Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Area Under Curve; Body Weight; Bronchoscopy; Chromatography, High Pressure Liquid; Drug Administration Schedule; Female; Fiber Optic Technology; Humans; Lidocaine; Male; Middle Aged | 1998 |
Prospective multivariate analysis of donor monoethylglycine xylidide (MEGX) testing in liver transplantation. Transplantation Society of Michigan Scientific Studies Committee.
Topics: Adult; Chi-Square Distribution; Graft Survival; Humans; Lidocaine; Liver Function Tests; Liver Transplantation; Logistic Models; Middle Aged; Organ Preservation; Predictive Value of Tests; Prospective Studies; Statistics, Nonparametric; Tissue Donors | 1998 |
Effects of reduced glutathione and n-acetylcysteine on lidocaine metabolism in cimetidine treated rats.
Topics: Acetylcysteine; Anesthetics, Local; Animals; Cimetidine; Drug Interactions; Fluorescence Polarization Immunoassay; Free Radical Scavengers; Glutathione; Histamine H2 Antagonists; Injections, Intraperitoneal; Lidocaine; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Determination of monoethylglycinexylidide by fluorescence polarization immunoassay in highly icteric serum samples: modified precipitation procedure and HPLC compared.
Topics: Chemical Precipitation; Chromatography, High Pressure Liquid; Fluorescence Polarization Immunoassay; Humans; Hyperbilirubinemia; Kidney Failure, Chronic; Lidocaine; Liver Transplantation; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity | 1998 |
Hepatic function as assessed by lidocaine metabolism in sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Case-Control Studies; Child; Child, Preschool; Coloring Agents; Dye Dilution Technique; Female; Half-Life; Homozygote; Humans; Indocyanine Green; Infant; Lidocaine; Liver; Liver Circulation; Liver Function Tests; Male; Time Factors | 1998 |
Evaluation of the function of primary human hepatocytes co-cultured with the human hepatic stellate cell (HSC) line LI90.
Topics: Cell Division; Cell Line; Cell Size; Child; Coculture Techniques; Cytochrome P-450 Enzyme System; Humans; Lidocaine; Liver; Liver, Artificial; Microscopy, Phase-Contrast; Urea | 1998 |
Monoethylglycinexylidide (MEGX) liver function test is not compromised by 3-hydroxy MEGX in humans.
Topics: Animals; Fluorescence Polarization Immunoassay; Humans; Hydroxylation; Lidocaine; Liver Function Tests; Sensitivity and Specificity | 1998 |
Commercially available media for flushing extracorporeal bioartificial liver systems prior to connection to the patient's circulation: an in vitro comparative study in two and three dimensional porcine hepatocyte cultures.
Topics: Animals; Artificial Organs; Aspartate Aminotransferases; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; L-Lactate Dehydrogenase; Lidocaine; Liver; Male; Organ Culture Techniques; Swine | 1998 |
Capillary gas chromatographic method for the measurement of small concentrations of monoethylglycinexylidide and lidocaine in plasma.
Topics: Chromatography, Gas; Humans; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests; Reproducibility of Results; Sensitivity and Specificity | 1998 |
Lidocaine in the horse: its pharmacological effects and their relationship to analytical findings.
Topics: Anesthetics, Local; Animals; Chromatography; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Horses; Injections, Subcutaneous; Lidocaine; Random Allocation; Reproducibility of Results | 1998 |
The monoethylglycinexylidide test for grading of liver cirrhosis.
Topics: Adult; Discriminant Analysis; Female; Humans; Lidocaine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Models, Biological; Sensitivity and Specificity | 1999 |
Pharmacokinetics of oral etoposide in patients with hepatocellular carcinoma.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Aspartate Aminotransferases; Bilirubin; Biological Availability; Blood Proteins; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Etoposide; Humans; Lidocaine; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Metabolic Clearance Rate; Middle Aged; Protein Binding; Serum Albumin; Ultrafiltration | 1999 |
The viability of liver graft for transplantation after prolonged warm ischaemia.
Topics: Alanine Transaminase; Animals; Bilirubin; Graft Survival; Ischemia; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Organ Preservation; Swine; Temperature; Time Factors | 1999 |
Assessment of liver function by the MEGX test in patients with schistosomiasis and cirrhosis.
Topics: Adult; Aged; Case-Control Studies; Cohort Studies; Female; Humans; Lidocaine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; ROC Curve; Schistosomiasis | 1999 |
Progressive liver functional impairment is associated with an increase in AST/ALT ratio.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Chronic Disease; Clinical Enzyme Tests; Disease Progression; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Lidocaine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Prognosis; Retrospective Studies; ROC Curve; Sensitivity and Specificity | 1999 |
[Monoethylglycinexylidide--a metabolite of lidocaine--as an index of liver function in chronic hepatic parenchymal diseases].
Topics: Adult; Aged; Chronic Disease; Female; Fluorescence Polarization Immunoassay; Humans; Lidocaine; Liver Diseases; Liver Function Tests; Male; Middle Aged | 1999 |
Dynamic measurement of metabolic function in the rat liver: an application of reverse microdialysis.
Topics: Animals; Cytochrome P-450 Enzyme System; Lidocaine; Liver; Male; Microdialysis; Rats; Rats, Sprague-Dawley | 1999 |
Effect of plasma alpha1-acid glycoprotein concentration on the accumulation of lidocaine metabolites during continuous epidural anesthesia in infants and children.
Topics: Anesthesia, Epidural; Anesthetics, Local; Child; Child, Preschool; Female; Humans; Infant; Lidocaine; Male; Orosomucoid; Protein Binding | 1999 |
Effect of endotoxin shock on the clearance of lidocaine and indocyanine green in the perfused rat liver.
Topics: Anesthetics, Local; Animals; Cimetidine; Coloring Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endotoxins; Enzyme Inhibitors; Indocyanine Green; Isoenzymes; Lidocaine; Liver; Male; Metabolic Clearance Rate; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Shock, Septic | 1999 |
Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro.
Topics: Anesthetics, Local; Autopsy; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Fluvoxamine; Humans; In Vitro Techniques; Ketoconazole; Lidocaine; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases | 1999 |
Influence of pancreatic islets on growth and differentiation of hepatocytes in co-culture.
Topics: Albumins; Animals; Biotransformation; Cell Division; Coculture Techniques; Collagen; Culture Media; Culture Media, Conditioned; Glucagon; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Lidocaine; Liver; Rats; Rats, Inbred Lew | 1999 |
[Lidocaine metabolism associated with epidural anesthesia in patients for hepatic surgery].
Topics: Aged; Anesthesia, Epidural; Anesthetics, Local; Cytochrome P-450 Enzyme System; Female; Hepatectomy; Humans; Inactivation, Metabolic; Injections, Epidural; Lidocaine; Liver; Male; Middle Aged | 1999 |
Cultivation of immortalized human hepatocytes HepZ on macroporous CultiSpher G microcarriers.
Topics: Amino Acids, Branched-Chain; Anesthetics, Local; Bioreactors; Biotransformation; Cell Culture Techniques; Cell Division; Cell Line, Transformed; Cold Temperature; Culture Media; Humans; L-Lactate Dehydrogenase; Lidocaine; Liver; Liver, Artificial; Microscopy, Electron; Microscopy, Electron, Scanning; Microspheres; Oxygen Consumption; Phenylalanine; Tyrosine | 2000 |
Can the MEGX test and serum bile acids improve the prognostic ability of Child-Pugh's score in liver cirrhosis?
Topics: Adult; Aged; Bile Acids and Salts; Female; Humans; Lidocaine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Predictive Value of Tests; Prognosis; Prospective Studies; ROC Curve | 1999 |
The lidocaine (MEGX) test as an index of hepatic function: its clinical usefulness in liver surgery.
Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Carcinoma, Hepatocellular; Female; Hepatectomy; Humans; Lidocaine; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Postoperative Complications; Predictive Value of Tests; Prothrombin Time; Quaternary Ammonium Compounds; Serum Albumin; Tissue Donors; Waiting Lists | 2000 |
Oral or intravenous lidocaine administration to perform megx test?
Topics: Administration, Oral; Diagnosis, Differential; Hepatitis; Humans; Infusions, Intravenous; Lidocaine; Liver Cirrhosis; Liver Function Tests; Predictive Value of Tests | 2000 |
Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis.
Topics: Adipose Tissue; Adult; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Leptin; Lidocaine; Liver Cirrhosis; Male; Middle Aged; Organ Size; Reference Values | 2000 |
Concentrations of lidocaine and monoethylglycine xylidide in brain, cerebrospinal fluid, and plasma during lidocaine-induced epileptiform electroencephalogram activity in rabbits: the effects of epinephrine and hypocapnia.
Topics: Anesthetics, Local; Animals; Brain; Cerebrospinal Fluid Pressure; Electroencephalography; Epilepsy; Epinephrine; Hypocapnia; Lidocaine; Rabbits | 2000 |
The monoethylglycinexylidide test does not impair psychometric performance in patients with chronic hepatitis or cirrhosis.
Topics: Adult; Aged; Female; Hepatic Encephalopathy; Hepatitis, Chronic; Humans; Lidocaine; Liver Cirrhosis; Male; Middle Aged | 2000 |
Histologic determinants of monoethylglycinexylidide formation in patients with chronic hepatitis C.
Topics: Adult; Aged; Female; Hepatitis C, Chronic; Humans; Lidocaine; Male; Middle Aged; Regression Analysis | 2000 |
Effects of chronic renal failure and hemodialysis on the monoethylglycinexylidide liver function test.
Topics: Humans; Injections, Intravenous; Kidney Failure, Chronic; Lidocaine; Liver Function Tests; Male; Middle Aged; Renal Dialysis | 2000 |
Plasma concentrations of monoethylglycinexylidide during and after breast augmentation.
Topics: Female; Humans; Lidocaine; Mammaplasty; Time Factors | 2000 |
Radial flow bioreactor outperforms hollow-fiber modules as a perfusing culture system for primary porcine hepatocytes.
Topics: Animals; Bioreactors; Carbon Dioxide; Cell Separation; Cytochrome P-450 Enzyme System; Dextrans; Equipment Design; Hepatocytes; Humans; Lidocaine; Liver; Liver, Artificial; Microspheres; Oxygen; Perfusion; Swine | 2000 |
[Dynamic liver function study using the lidocaine test].
Topics: Humans; Lidocaine; Liver; Liver Function Tests | 2000 |
The validity of the MEGX test in correlation with histology after orthotopic rat liver transplantation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Cholinesterases; Lidocaine; Liver Transplantation; Male; Rats; Rats, Inbred Lew; Reproducibility of Results; Transplantation, Isogeneic | 1994 |
Could local anesthesia while breast-feeding be harmful to infants?
Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Breast Feeding; Chromatography, High Pressure Liquid; Female; Humans; Lidocaine; Milk, Human; Safety | 2001 |
The effects of norepinephrine and prostaglandin E1 on pharmacokinetics of lidocaine in isolated perfused rat liver.
Topics: Alprostadil; Animals; Drug Interactions; In Vitro Techniques; Lidocaine; Liver; Male; Models, Biological; Norepinephrine; Perfusion; Portal Pressure; Rats; Rats, Sprague-Dawley | 2001 |
Long-term follow up of chronic hepatitis C patients after alpha-interferon treatment: a functional study.
Topics: Adult; Antiviral Agents; Female; Follow-Up Studies; Hepatitis C, Chronic; Humans; Interferon-alpha; Lidocaine; Liver; Liver Function Tests; Male; Middle Aged; Recurrence | 2001 |
Assessment of hepatic function in cystic fibrosis by lidocaine metabolism.
Topics: Adolescent; Adult; Case-Control Studies; Child; Cystic Fibrosis; Dye Dilution Technique; Female; Half-Life; Humans; Indocyanine Green; Lidocaine; Liver; Liver Circulation; Liver Function Tests; Male | 2001 |
Reassessment of monoethylglycinexylidide as preoperative liver function test in a rat model of liver cirrhosis and man.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Disease Models, Animal; Hepatectomy; Hepatitis; Hepatitis C, Chronic; Humans; Indicators and Reagents; Indocyanine Green; Lidocaine; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Organic Chemicals; Prothrombin Time; Rats; Rats, Wistar; Regression Analysis; Serum Albumin; Thioacetamide | 2001 |
Rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of monoethylglycinexylidide.
Topics: Chromatography, Liquid; Humans; Lidocaine; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Long-term expression of highly differentiated functions by isolated porcine hepatocytes perfused in a radial-flow bioreactor.
Topics: Albumins; Ammonia; Animals; Bioreactors; Cells, Cultured; Hepatocytes; Hydrogen-Ion Concentration; Lidocaine; Oxygen; Swine; Urea | 2001 |
Impairment of cytochrome P-450-dependent liver activity in cirrhotic patients with Helicobacter pylori infection.
Topics: Aged; Breath Tests; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Female; Galactose; Helicobacter Infections; Helicobacter pylori; Humans; Immunoglobulin G; Lidocaine; Liver; Liver Cirrhosis; Male; Middle Aged; Retrospective Studies; Tumor Necrosis Factor-alpha | 2001 |
Correlation between midazolam and lignocaine pharmacokinetics and MEGX formation in healthy volunteers.
Topics: Adult; Drug Interactions; Erythromycin; Female; Humans; Hypnotics and Sedatives; Lidocaine; Liver Function Tests; Male; Midazolam; Time Factors | 2002 |
Deferoxamine and hespan complex as a resuscitative adjuvant in hemorrhagic shock rat model.
Topics: Animals; Deferoxamine; Hydroxyethyl Starch Derivatives; Iron Chelating Agents; Isotonic Solutions; Lidocaine; Liver Circulation; Male; Rats; Rats, Sprague-Dawley; Resuscitation; Ringer's Lactate; Shock, Hemorrhagic | 2002 |
Biochemical function of the donor liver in living related liver transplantation.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Family; Female; Hepatectomy; Hippurates; Humans; Ketone Bodies; L-Lactate Dehydrogenase; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Living Donors; Male; Retrospective Studies | 2002 |
Risk of hepatic failure after transcatheter arterial chemoembolization for hepatocellular carcinoma: predictive value of the monoethylglycinexylidide test.
Topics: Aged; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Female; Humans; Lidocaine; Liver Failure; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Osmolar Concentration; Predictive Value of Tests; Risk Factors | 2002 |
Involvement of liver carboxylesterases in the in vitro metabolism of lidocaine.
Topics: Anesthetics, Local; Animals; Carboxylesterase; Carboxylic Ester Hydrolases; Hydrolysis; Hydroxylation; In Vitro Techniques; Lidocaine; Male; Microsomes, Liver; Rabbits; Rats; Species Specificity; Swine | 2002 |
Effect of dopamine-induced changes in splanchnic blood flow on MEGX production from lidocaine in septic and cardiac surgery patients.
Topics: Adult; Aged; Dopamine; Female; Humans; Lidocaine; Male; Middle Aged; Sepsis; Splanchnic Circulation; Thoracic Surgery | 2002 |
Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Animals; Blotting, Western; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Epoxide Hydrolases; Kinetics; Lidocaine; Male; Microsomes; Microsomes, Liver; Olfactory Mucosa; Polychlorinated Dibenzodioxins; Rats; Rats, Sprague-Dawley | 2002 |
Cultivation of porcine hepatocytes in polyurethane nonwovens as part of a biohybrid liver support system.
Topics: Albumins; Ammonia; Animals; Bioreactors; Cell Survival; Cells, Cultured; Glucose; Hepatocytes; L-Lactate Dehydrogenase; Lidocaine; Liver, Artificial; Oxygen Consumption; Polyurethanes; Rats; Rats, Inbred Lew; Surface Properties; Swine | 2002 |
MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is correlated with residual liver function: a European study.
Topics: Adult; Aged; Epidemiologic Methods; Female; Humans; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Prognosis | 2003 |
Functional significance of hepatic arterial flow reserve in patients with cirrhosis.
Topics: Adenosine; Adult; Blood Flow Velocity; Blood Volume; Coloring Agents; Female; Galactose; Hepatic Artery; Humans; Indocyanine Green; Lidocaine; Liver Cirrhosis; Male; Middle Aged; Pulse; Regional Blood Flow; Severity of Illness Index; Vasodilation | 2003 |
Modulation of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) gene expression in isolated porcine hepatocytes perfused within a radial-flow bioreactor after low-temperature storing.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Bioreactors; Cell Culture Techniques; Cell Survival; Gene Expression; Genes, bcl-2; Hepatocytes; Lidocaine; Liver, Artificial; Perfusion; Preservation, Biological; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Swine | 2003 |
MEGX disposition in critically-ill trauma patients: subsequent assessments during the first week following trauma.
Topics: Adult; Aged; APACHE; Area Under Curve; Biomarkers; Critical Illness; Female; Half-Life; Humans; Lidocaine; Liver; Liver Function Tests; Male; Time Factors; Wounds and Injuries | 2002 |
Chromatographic determination of free lidocaine and its active metabolites in plasma from patients under epidural anesthesia.
Topics: Adult; Anesthesia, Epidural; Anesthetics, Local; Blood Proteins; Chromatography, High Pressure Liquid; Humans; Lidocaine; Male; Middle Aged; Protein Binding; Time Factors | 2002 |
Influence of prolonged cardiopulmonary bypass times on splanchnic perfusion and markers of splanchnic organ function.
Topics: Aged; Antigens, Neoplasm; Biomarkers; Biomarkers, Tumor; Carbon Dioxide; Cardiopulmonary Bypass; Coronary Artery Bypass; Female; Gastric Mucosa; Glutathione Transferase; Humans; Isoenzymes; Lectins, C-Type; Lidocaine; Liver; Liver Function Tests; Male; Pancreas; Pancreatitis-Associated Proteins; Prospective Studies; Splanchnic Circulation; Time Factors | 2003 |
Distributions of ethanol and intubation-related lidocaine in the brain of a trauma patient who was brain dead for about 5 days.
Topics: Anesthetics, Local; Autopsy; Brain; Brain Death; Cardiopulmonary Resuscitation; Central Nervous System Depressants; Ethanol; Gels; Humans; Intubation, Intratracheal; Lidocaine; Male; Middle Aged; Subarachnoid Hemorrhage; Tissue Distribution | 2003 |
The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats.
Topics: Anesthetics, Local; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Gas Analysis; Brain; Bupivacaine; Chromatography, High Pressure Liquid; Hemodynamics; Hydrogen-Ion Concentration; Lidocaine; Male; Quinidine; Rats; Rats, Sprague-Dawley; Seizures | 2003 |
Tissue distribution of lidocaine in critical care patients after intubation.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Cardiopulmonary Resuscitation; Child; Child, Preschool; Critical Care; Humans; Intubation, Intratracheal; Japan; Lidocaine; Male; Middle Aged; Tissue Distribution | 2003 |
Experimental study of the evaluation of liver function on the opposite side during portacaval anastomosis and ligation of the left portal branch.
Topics: Animals; Carcinoma, Hepatocellular; Dogs; Humans; Indocyanine Green; Lidocaine; Ligation; Liver Circulation; Liver Function Tests; Liver Neoplasms; Models, Animal; Portacaval Shunt, Surgical; Portal Vein | 2004 |
N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: extended case report.
Topics: Acetylcysteine; Adult; Aged; Antioxidants; Female; Hemodynamics; Humans; Lactates; Lidocaine; Liver; Liver Circulation; Liver Function Tests; Magnetic Resonance Spectroscopy; Male; Middle Aged; Oxygen Consumption; Prospective Studies; Shock, Septic; Signal Transduction; Survival Analysis; Vasoconstriction | 2004 |
Liquid chromatographic method for the determination of lidocaine and monoethylglycine xylidide in human serum containing various concentrations of bilirubin for the assessment of liver function.
Topics: Bilirubin; Calibration; Chromatography, High Pressure Liquid; Humans; Lidocaine; Liver Diseases; Liver Function Tests; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2004 |
Use of lidocaine metabolism to test liver function during the long-term follow-up of liver transplant recipients.
Topics: Adolescent; Adult; Female; Follow-Up Studies; Humans; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Prospective Studies; Time Factors | 2004 |
Splanchnic oxygen transport, hepatic function and gastrointestinal barrier after normothermic cardiopulmonary bypass.
Topics: Adult; Aged; Aged, 80 and over; Cardiopulmonary Bypass; Coloring Agents; Female; Flurothyl; Gastrointestinal Tract; Humans; Lactic Acid; Lactulose; Lidocaine; Liver; Liver Function Tests; Male; Mannitol; Middle Aged; Oxygen; Postoperative Complications; Prospective Studies; Splanchnic Circulation; Sucrose; Time Factors | 2004 |
Development of a protocol for cryopreservation of hepatocytes for use in bioartificial liver systems.
Topics: Animals; Bilirubin; Bioreactors; Cell Count; Cells, Cultured; Cryopreservation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Hepatocytes; Lidocaine; Liver; Liver, Artificial; Organ Preservation; Swine; Time Factors | 2004 |
Pharmacokinetics and safety of lidocaine and monoethylglycinexylidide in liposuction: a microdialysis study.
Topics: Adipose Tissue; Adult; Anesthetics, Local; Dose-Response Relationship, Drug; Female; Humans; Lidocaine; Lipectomy; Metabolic Clearance Rate; Microdialysis; Postoperative Period; Risk Assessment | 2004 |
Pharmacokinetics of lidocaine delivered from a transmucosal patch in children.
Topics: Administration, Buccal; Anesthetics, Local; Central Nervous System; Child; Child, Preschool; Drug Delivery Systems; Fluorescence Polarization Immunoassay; Humans; Lidocaine | 2002 |
Assessment of hepatic reserve for indication of hepatic resection: how I do it.
Topics: Carcinoma, Hepatocellular; Female; Hepatectomy; Humans; Lidocaine; Liver Cirrhosis; Liver Failure; Liver Function Tests; Liver Neoplasms; Male; Patient Selection; Postoperative Complications; Statistics, Nonparametric; Treatment Outcome | 2005 |
Analysis of lidocaine and its major metabolite, monoethylglycinexylidide, in elk velvet antler by liquid chromatography with UV detection and confirmation by electrospray ionization tandem mass spectrometry.
Topics: Animals; Antlers; Chromatography, Liquid; Lidocaine; Male; Ruminants; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Monoethylglycinexylidide and lidocaine determination in porcine microsomal preparations.
Topics: Animals; Chromatography, High Pressure Liquid; Indicators and Reagents; Lidocaine; Microsomes; Reference Standards; Solutions; Spectrophotometry, Ultraviolet; Swine | 2005 |
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes.
Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal | 2005 |
Assessment of the hemodynamic effects of lidocaine administered IV in isoflurane-anesthetized cats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Blood Pressure; Cats; Drug Interactions; Heart Rate; Hemodynamics; Isoflurane; Lidocaine; Pain | 2005 |
Pharmacokinetics of lidocaine and its active metabolite, monoethylglycinexylidide, after intravenous administration of lidocaine to awake and isoflurane-anesthetized cats.
Topics: Anesthesia, General; Anesthetics; Anesthetics, Combined; Animals; Area Under Curve; Cats; Drug Interactions; Half-Life; Injections, Intravenous; Isoflurane; Lidocaine | 2005 |
Prognostic value of quantitative liver function tests in viral cirrhosis: a prospective study.
Topics: Adult; Disease Progression; Epidemiologic Methods; Female; Galactose; Hepatitis, Viral, Human; Humans; Lidocaine; Liver Cirrhosis; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Prognosis; Severity of Illness Index | 2006 |
[Evaluation of the liver reserve using lidocaine test on experimental liver injuries in rats].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Lidocaine; Liver; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Random Allocation; Rats; Rats, Wistar | 2006 |
Lidocaine metabolism in isolated perfused liver from streptozotocin-induced diabetic rats.
Topics: Anesthetics, Local; Animals; Body Weight; Diabetes Mellitus, Experimental; In Vitro Techniques; Lidocaine; Liver; Rats; Rats, Wistar | 2006 |
Assessment of liver function in children with acute lymphoblastic leukemia in remission.
Topics: Adolescent; Adult; Area Under Curve; Child; Diagnosis, Differential; Female; Half-Life; Hepatitis, Chronic; Humans; Lidocaine; Liver; Liver Function Tests; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Values; Remission Induction | 2006 |
Pharmacokinetics of tilidine and naloxone in patients with severe hepatic impairment.
Topics: Adult; Aged; Analgesics, Opioid; Area Under Curve; Biotransformation; Chromatography, Gas; Female; Half-Life; Humans; Lidocaine; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Naloxone; Narcotic Antagonists; Tilidine | 2007 |
Reporting a fatality during tumescent liposuction.
Topics: Adult; Ambulatory Care; Anesthetics, Local; Drug Overdose; Epilepsy, Tonic-Clonic; Epinephrine; Fatal Outcome; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Lidocaine; Lipectomy; Malpractice; Mepivacaine; Vasoconstrictor Agents | 2008 |
[Determination of monoethylglycinexylidide concentration in serum using solid phase extraction and capillary gas chromatography-mass spectrometry].
Topics: Animals; Blood Chemical Analysis; Calibration; Gas Chromatography-Mass Spectrometry; Lidocaine; Rats; Reproducibility of Results; Solid Phase Extraction; Time Factors | 2008 |
Cutaneous in vivo metabolism of topical lidocaine formulation in human skin.
Topics: Adolescent; Adult; Anesthetics, Local; Biotransformation; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Humans; Lidocaine; Liver; Male; Mass Spectrometry; Skin; Young Adult | 2009 |
Lidocaine/monoethylglycinexylidide test, galactose elimination test, and sorbitol elimination test for metabolic assessment of liver cell bioreactors.
Topics: Animals; Bioreactors; Cell Culture Techniques; Cells, Cultured; Galactose; Hepatocytes; Humans; Lidocaine; Liver; Liver Function Tests; Liver, Artificial; Sorbitol; Swine | 2010 |
[Determination of lidocaine and its metabolites in human plasma by liquid chromatography in combination with tandem mass spectrometry].
Topics: Anesthetics, Local; Chromatography, High Pressure Liquid; Humans; Lidocaine; Tandem Mass Spectrometry | 2010 |
Lidocaine metabolites inhibit glycine transporter 1: a novel mechanism for the analgesic action of systemic lidocaine?
Topics: Anesthetics, Local; Animals; Astrocytes; Blotting, Western; Cerebral Cortex; Female; Glycine; Glycine Plasma Membrane Transport Proteins; Lidocaine; Microglia; Microscopy, Fluorescence; Mitochondria; N-substituted Glycines; Neurons; Oligodendroglia; Oocytes; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Xenopus laevis | 2012 |
Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures.
Topics: Animals; Cattle; Chromatography, Liquid; Drug Monitoring; Humans; Infant, Newborn; Lidocaine; Linear Models; Reproducibility of Results; Seizures; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Can fractional lasers enhance transdermal absorption of topical lidocaine in an in vivo animal model?
Topics: Administration, Cutaneous; Anesthetics, Local; Animals; Drug Delivery Systems; Lasers, Solid-State; Lidocaine; Skin Absorption; Swine | 2012 |
Pharmacokinetics of lidocaine and its metabolite as a hepatic function marker in dogs.
Topics: Anesthetics, Local; Animals; Area Under Curve; Biomarkers; Dogs; Female; Lidocaine; Liver; Male | 2011 |
Formation of monoethylglycinexylidide (MEGX) in clinically healthy dogs.
Topics: Anesthetics, Local; Animals; Dogs; Female; Lidocaine; Liver; Liver Function Tests; Male | 2011 |
Use of lidocaine in endotracheal intubation. Blood and urine concentrations in patients and deceased after unsuccessful resuscitation.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Cardiopulmonary Resuscitation; Cardiovascular Surgical Procedures; Cohort Studies; Forensic Toxicology; Gels; Humans; Intubation, Intratracheal; Lidocaine; Middle Aged | 2014 |
Flexible Method for Analysis of Lidocaine and Its Metabolite in Biological Fluids.
Topics: Acetonitriles; Animals; Biotransformation; Cats; Cattle; Chromatography, Liquid; Dogs; Formates; Horses; Humans; Lidocaine; Limit of Detection; Milk; Reproducibility of Results; Solid Phase Extraction; Solvents; Tandem Mass Spectrometry | 2016 |
Shear wave elastography results correlate with liver fibrosis histology and liver function reserve.
Topics: Animals; Dogs; Elasticity Imaging Techniques; Female; Lidocaine; Liver; Liver Cirrhosis, Experimental; Male | 2016 |
Evaluation of different blood tests in dogs with extrahepatic portosystemic shunts to assess shunt closure after surgical treatment.
Topics: Ammonia; Animals; Bile Acids and Salts; Dog Diseases; Dogs; Hematologic Tests; Hyaluronic Acid; Lidocaine; Portal System; Portasystemic Shunt, Transjugular Intrahepatic; Prospective Studies | 2022 |
Effects of two continuous infusion doses of lidocaine on isoflurane minimum anesthetic concentration in chickens.
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Chickens; Cross-Over Studies; Female; Heart Rate; Isoflurane; Lidocaine; Prospective Studies; Pulmonary Alveoli | 2023 |
Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation.
Topics: Hepatectomy; Humans; Lidocaine; Liver | 2023 |
Pharmacokinetics and metabolism of lidocaine HCl 2% with epinephrine in horses following a palmar digital nerve block.
Topics: Anesthetics, Local; Animals; Epinephrine; Horses; Lidocaine; Nerve Block | 2023 |