lidocaine has been researched along with mexiletine in 253 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 128 (50.59) | 18.7374 |
| 1990's | 49 (19.37) | 18.2507 |
| 2000's | 45 (17.79) | 29.6817 |
| 2010's | 25 (9.88) | 24.3611 |
| 2020's | 6 (2.37) | 2.80 |
| Authors | Studies |
|---|---|
| Bódi, I; Frank, L; Hankovszky, OH; Hideg, K | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Anger, T; Madge, DJ; Mulla, M; Riddall, D | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Calogeropoulou, T; Horváth, Z; Koini, EN; Koncz, I; Koufaki, M; Papazafiri, P; Papp, GJ; Varró, A; Vassilopoulos, A; Virág, L | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Sen, S; Sinha, N | 1 |
| Bruno, C; Budriesi, R; Carbonara, R; Carocci, A; Catalano, A; Colabufo, NA; Conte Camerino, D; De Palma, A; Desaphy, JF; Di Mola, A; Franchini, C; Ghelardini, C; Lentini, G; Perrone, MG | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Bennis, K; Ducki, S; Lesage, F; Vivier, D | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Julian, DG | 1 |
| Theisen, K | 1 |
| Carson, IW; Lyons, SM; Shanks, RG | 1 |
| Coumel, P; Krikler, D; Rosen, MR; Wellens, HJ; Zipes, DP | 1 |
| Chiariello, M; Condorelli, M; Ferro, G; Santinelli, V; Tari, MG | 1 |
| Adgey, AA; Webb, SW | 1 |
| Flanagan, RJ; Hayler, AM; Holt, DW; Loizou, M | 1 |
| Adgey, AA; Campbell, NP; Pantridge, JF | 1 |
| Anderson, JL; Harrison, DC; Meffin, PJ; Winkle, RA | 1 |
| Holt, DW; Joseph, SP | 1 |
| Troup, PJ; Zipes, DP | 1 |
| Williams, EM | 1 |
| Allen, JD; James, RG; Kelly, JG; Shanks, RG; Zaidi, SA | 1 |
| Shaw, TR | 1 |
| Kidner, PH | 1 |
| Arita, M; Kiyosue, T; Sato, T; Wu, B | 1 |
| Kato, R; Koide, M; Miyahara, T; Sotobata, I; Toyama, J; Ukai, M; Yasui, S; Yokota, M | 1 |
| Chin, M; Franz, M; Herre, JM; Katzung, B; Newman, D; Scheinman, MM | 1 |
| Furukawa, T; Hiraoka, M; Marumo, F; Nitta, J; Sawanobori, T; Sunami, A | 1 |
| Handa, S; Ogawa, S; Okada, Y; Sadanaga, T | 1 |
| Ikeda, N; Kamiya, K | 1 |
| Ballew, KA; Geraets, DR; Scott, SD | 1 |
| Kamiya, K; Kodama, I; Toyama, J | 1 |
| Gries, FA; Ziegler, D | 1 |
| Annesley, T; vasBinder, E | 1 |
| Ackerman, WE; Bellinger, K; Colclough, GW; Juneja, MM | 1 |
| Fukami, M; Hashimoto, T; Itoh, Y; Koike, H; Kumakura, S; Miyake, S; Mizuno, H; Shiga, H; Shimoji, Y; Yorikane, R | 1 |
| Brose, WG; Tanelian, DL | 1 |
| Dai, RH; Shi, HM; Wang, SY | 1 |
| Chiavarelli, M; Chiavarelli, R; del Basso, P; Fabi, F; Stati, T | 1 |
| Desai, DM; Gal, J; Meyer-Lehnert, S | 1 |
| Kyo, K; Niijima, S; Ohtsuka, C; Saito, M; Sato, Y; Tada, H; Takahashi, H; Takahashi, K; Yabuta, K | 1 |
| Leffler, J; Lüderitz, B; Nitsch, J | 1 |
| Roden, DM | 2 |
| Podrid, PJ | 2 |
| Arita, M; Kiyosue, T; Ono, K | 1 |
| Lüderitz, B; Manz, M; Wagner, WL | 1 |
| Aisaka, K; Hattori, Y; Hidaka, T; Ishihara, T; Satoh, F | 1 |
| Graboys, TB; Grossbard, CL; Lown, B; Patt, MV | 1 |
| Kawakubo, K; Murakawa, Y; Nozaki, A; Sugimoto, T; Toda, I | 1 |
| Martinez, R; Swerdlow, CD | 1 |
| Grauer, K; Gums, J; Skluth, H | 1 |
| Barbey, JT; Echt, DS; Kopelman, HA; Murray, KT; Roden, DM; Siddoway, LA; Woosley, RL | 1 |
| Snyder, DW | 1 |
| Lampert, S; Lown, B; Podrid, PJ; Ravid, S | 1 |
| Burchiel, KJ; Chabal, C; Russell, LC | 1 |
| Aguglia, F; De Marzio, P; Gnecchi, M | 1 |
| Horowitz, JD; Louis, WJ; Morgan, DJ | 1 |
| Costard-Jäckle, A; Franz, MR | 1 |
| Yamaguchi, I | 1 |
| Somberg, J | 1 |
| Roden, DM; Siddoway, LA; Woosley, RL | 1 |
| Roy, D | 1 |
| Boysen, G; Kastrup, J; Petersen, P; Zeeberg, I | 1 |
| Muzio, L; Romanò, M; Spinelli, A | 1 |
| Blum, R; Hession, M; Lampert, S; Lown, B; Podrid, PJ; Stein, J | 1 |
| Andersson, KE; Wettrell, G | 1 |
| Morganroth, J; Nestico, PF | 2 |
| Huang, SK; Marcus, FI | 1 |
| Bernard, R; de Hemptinne, J; Gillet, JM; Lewinson, H; Liebens, I; Renard, M; Shita, A; Waterschoot, P | 1 |
| Bauman, JL; Deal, BJ; Gallastegui, JL; Hariman, RJ; Martinez, JJ; Miller, SM; Scagliotti, D | 1 |
| Horowitz, LN; Morganroth, J | 1 |
| Di Biase, M; Favale, S; Rizzon, P; Visani, L | 1 |
| Eigenberg, MC | 1 |
| Easley, AR; Mann, DE; Reiter, MJ | 1 |
| Hattori, Y; Ishihara, T; Kodama, I; Kusunoki, T; Toyama, J; Yamada, K | 1 |
| Woosley, RL | 1 |
| Hammill, SC; Kreeger, RW | 1 |
| Linderer, EM; Tippe, A | 1 |
| Geibel, A; Hohnloser, S; Just, H; Meinertz, T; Treese, N; Zehender, M | 1 |
| Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K | 1 |
| Hatta, M; Hattori, Y; Hirose, N; Hirotsu, I; Ishihara, T; Kihara, T; Satoh, F | 1 |
| Elharrar, V | 1 |
| Nattel, S | 1 |
| Jaszlits, L; Kürthy, M; Rabloczky, G; Toldy, L; Varró, A; Zubovics, Z | 1 |
| Steiner, C; Vozeh, S | 1 |
| Dynon, MK; Goble, AJ; Horowitz, JD; Louis, WJ; Macdonald, PS; Morgan, DJ; Sia, ST; Woodward, E | 1 |
| Schwartz, PJ; Vanoli, E | 1 |
| Chan, MC; Harris, FJ; Lee, G; Lui, HK; Mason, DT | 1 |
| Kastrup, J; Petersen, P | 1 |
| Abete, P; Bonaduce, D; Canonico, V; Ferrara, N; Leosco, D; Longobardi, G; Morgano, G; Rengo, F | 1 |
| Kasahara, T; Kawashima, I; Manabe, A; Nakayama, S; Sakamoto, K; Shirasaki, K | 1 |
| Hirosawa, K; Kasanuki, H; Onishi, S | 1 |
| Collignon, P; Legrand, V | 1 |
| Gupta, RN; Lew, M | 1 |
| Fukuzaki, H; Itoh, S; Kobayashi, K | 1 |
| Berman, ND; Burke, GH; Loukides, JE | 1 |
| Schwartz, PJ; Vanoli, E; Zaza, A; Zuanetti, G | 1 |
| Burali, A; Forzoni, M; Lucioli, F | 1 |
| Kitagawa, H; Kohei, H; Takeda, F | 1 |
| Sanna, GP | 1 |
| Opie, LH | 1 |
| Almotrefi, AA; Baker, JB | 1 |
| Schmitz, W | 1 |
| Hillis, WS; Whiting, B | 1 |
| Somberg, JC | 1 |
| Doherty, JU; Josephson, ME; Kienzle, MG; Williams, PD; Zygmont, D | 1 |
| Fossati, C; Giustiniani, S | 1 |
| Jahrmärker, H; Theisen, K | 1 |
| Bonatti, V; Botti, G; Favaro, L; Finardi, A; Rolli, A | 1 |
| Codecà, L; Gruppillo, P; Masoni, A; Masoni, C; Padovan, GC | 2 |
| Duff, HJ; Oates, JA; Roden, DM; Woosley, RL | 1 |
| Mohiuddin, SM; Ross, WB | 1 |
| Lüderitz, B | 1 |
| Courtney, KR | 1 |
| Castleden, CM; Clarkson, EJ; Duffin, HM | 1 |
| Arpino, I; Barbi, S; Guidi, ML; Pala, F; Sabato, AF; Sammartino, M | 1 |
| Bhatia, ML; Kaul, U; Mohan, JC | 1 |
| Rosen, MR; Wit, AL | 1 |
| Block, PJ; Winkle, RA | 1 |
| Pottage, A | 1 |
| Colley, DG; Duff, HJ; Maffucci, R; Marney, S; Oates, JA; Primm, RK; Roden, DM; Woosley, RL | 1 |
| Rossi, L | 1 |
| Harrison, DC; Mead, RH | 1 |
| Hellestrand, KJ | 1 |
| Heger, JJ; Prystowsky, EN; Zipes, DP | 1 |
| Luck, JC; Mann, DE; Pratt, CM; Wyndham, CR | 1 |
| Follath, F; Vozeh, S; Wenk, M | 1 |
| Fritz, KW; Kirchner, E; Lüllwitz, E; Scheld, H | 1 |
| Gülzow, J; Hildenbrand, H; Hönerloh, HJ; Lenarz, T | 1 |
| Abinader, EG | 1 |
| Geisler, C; Keiding, S | 1 |
| Cho, YW; Kuemmerle, HP; Singh, BN | 1 |
| Nademanee, K; Singh, BN | 1 |
| Flouvat, B | 1 |
| Witkowska, M | 1 |
| Mouselimis, N; Wester, HA | 1 |
| Atallah, G; Kirkorian, G; Moleur, P; Touboul, P | 1 |
| Hirosawa, K; Kasanuki, H; Ohnishi, S | 1 |
| Hashimoto, K; Imai, S; Satoh, H; Shibuya, T | 1 |
| Chiariello, M; Condorelli, M; Santinelli, V; Stanislao, M | 1 |
| Chiariello, M; Condorelli, M; Ferro, G; Tari, MG; Ungaro, B; Vigorito, C | 1 |
| Fritz, KW; Hempelmann, G; Riethmüller, H | 1 |
| Boyle, DM | 1 |
| Condorelli, M; De Luca, N; Rengo, F; Ricciardelli, B; Sacca', L; Trimarco, B; Volpe, M | 1 |
| Bury, RW; Hale, G; Higginbotham, M; Mashford, ML; Zuidland, P | 1 |
| Kékány, P; Keltai, M; Mádai, A | 1 |
| Chiariello, M; Clarizia, M; Condorelli, M; Santinelli, V; Stanislao, M; Turco, P | 1 |
| Adgey, AA; Logan, KR; McIlwaine, WJ; Pantridge, JF | 1 |
| Bonaduce, D; Condorelli, M; D'Ascia, C; De Luca, N; Rengo, F; Ricciardelli, B; Trimarco, B; Volpe, M | 1 |
| Kakinohana, O; Okuda, Y | 1 |
| Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Sakai, R; Shirayama, T; Yamahara, Y | 1 |
| Brown, RH; Hirshman, C; Robbins, W; Staats, P | 1 |
| Harada, H; Kamiyama, T; Nakai, K; Takeo, S; Tanonaka, K | 1 |
| Loi, CM; Schmucker, DL; Vestal, RE; Wei, X | 1 |
| Hoener, BA | 1 |
| Fukuda, H; Kasuda, H; Nemoto, K; Shimizu, R | 1 |
| Beric, A; Edmondson, EA; Simpson, RK; Stubler, DK | 1 |
| Christie, JM; Markowsky, SJ; Valdes, C | 1 |
| Boulton, AJ | 1 |
| Akaishi, M; Handa, S; Iwanaga, S; Ogawa, S; Okada, Y; Sadanaga, T; Tsutsumi, N; Yoshikawa, T | 1 |
| Aizawa, Y; Mitamura, H; Miyazaki, T; Miyoshi, S; Ogawa, S; Soejima, K | 1 |
| Short, S; Zapp, JJ | 1 |
| Jarvi, EJ; Loi, CM; Vestal, RE; Wei, X | 1 |
| Galer, BS; Harle, J; Rowbotham, MC | 1 |
| Brown, RH; Foster, WM; Groeben, H | 1 |
| Aihara, M; Hatakeyama, K; Hinohara, Y; Kamiya, Y; Kanemura, H; Nakazawa, S; Sata, Y; Shimoda, C | 1 |
| Adgey, AA; Allen, JD; Devine, AB; Stewart, AJ | 1 |
| Duggan, S; Loomis, C; Milne, B | 1 |
| Fernández del Pozo, B; Fernández, C; Pérez-Vizcaíno, F; Tamargo, J; Zaragozá, F | 1 |
| Zemenick, RB | 1 |
| Arita, M; Sato, T; Shigematsu, S | 1 |
| Imagawa, N; Sato, S | 1 |
| Backx, PH; Sah, RL; Tsushima, RG | 1 |
| Hayashi, R; Miki, J; Momoi, H; Ohara, S; Yanagisawa, N | 1 |
| Hayashi, R; Ohara, S; Tsuyuzaki, J | 1 |
| Hatano, Y; Ishikawa, T; Kinoshita, H | 1 |
| Kanazawa, I; Sakurai, M | 1 |
| Dai, R; Friedman, FK; Thummel, KE; Vestal, RE; Wei, X; Zhai, S | 1 |
| Miyamoto, A; Oki, J; Takahashi, S | 1 |
| Davis, MD; Kuhnert, SM; Phillips, WJ | 1 |
| Enoki, H; Hata, H; Kobayashi, K; Maniwa, S; Ohmori, I; Ohta, H | 1 |
| Chen, LL; Mao, J | 1 |
| Horiuchi, J; Sato, Y | 1 |
| Bräu, ME; Dreimann, M; Hempelmann, G; Olschewski, A; Vogel, W | 1 |
| Dojo, M; Hatano, Y; Iranami, H; Kimoto, Y; Kinoshita, H | 1 |
| Ishii, K; Moriuchi, H; Nakahara, T; Sakamato, K; Yunoki, M | 1 |
| Kawano, T; Kitahata, H; Kuroda, Y; Nakaya, Y; Oshita, S; Tomiyama, Y; Tsutsumi, Y | 1 |
| Ishii, K; Kubota, Y; Moriuchi, H; Nakahara, T; Sakamato, K; Yunoki, M | 1 |
| Heidenreich, F; Schiltz, K; Steiner, J; Weissenborn, K | 1 |
| Fukuzawa, M; Funakoshi, S; Kugaya, Y; Maeda, Y; Murakami, T; Nakamura, M; Takano, M; Tsukiai, S; Yamasaki, M | 1 |
| Blackburn-Munro, G; Erichsen, HK; Hao, JX; Xu, XJ | 1 |
| Dupre, D; Guillet, G; Kupfer, I; Legroux-Crespel, E; Misery, L; Sassolas, B | 1 |
| Fu, LT; Iinuma, H; Sagara, K; Sahara, M; Watanabe, H; Yamashita, T | 1 |
| Akiba, I; Barsoumian, EL; Iizuka, M; Imoto, K; Mori, M; Nishimura, S; Sasaki, S; Seki, T | 1 |
| Attal, N; Bouhassira, D; Brasseur, L; Chauvin, M; Rouaud, J | 1 |
| Ishii, K; Karikomi, Y; Kubota, Y; Nakahara, T; Sakamoto, K | 1 |
| Ando, A; Hirai, M; Inden, Y; Isobe, S; Murohara, T; Nonokawa, M; Okada, M; Suzuki, A; Takada, Y; Tomita, Y | 1 |
| Hiraoka, M; Kimura, A; Kitabatake, A; Makita, N; Sakurada, H; Sasaki, K; Shirai, N; Sunami, A; Tohse, N; Yokoi, H | 1 |
| Imaki, R; Inuo, K; Izumi, T; Morohoshi, Y; Nakayama, S; Niwano, S; Yuge, M | 1 |
| Backx, PH; Li, RA; Tomaselli, GF; Tsang, SY; Tsushima, RG | 1 |
| Sasaki, K | 1 |
| Onishi, S; Yokoyama, Y | 1 |
| Dojo, M; Hatano, Y; Kimoto, Y; Kinoshita, H; Nakahata, K | 1 |
| Guite, JW; Hehir, D; Milovcich, K; Nathan, A; Rose, JB | 1 |
| Carr, DB; Challapalli, V; Lau, J; McNicol, ED; Tremont-Lukats, IW | 2 |
| Weiser, T | 1 |
| Ebell, MH | 1 |
| Al-Shurbaji, A; Alván, G; Berninger, E; Idrizbegovic, E; Karlsson, KK; Meurling, L; Nordmark, J | 1 |
| Carroll, I | 1 |
| Chen, YW; Cheng, KI; Chu, CC; Chu, KS; Huang, KL; Tzeng, JI; Wang, JJ | 1 |
| Grafe, P; Hilmer, VB; Lang, PM | 1 |
| Carroll, IR; Kaplan, KM; Mackey, SC | 1 |
| Schere, D; Silberstein, SD | 1 |
| Bräu, ME; Li, Y; Olschewski, A; Schnoebel-Ehehalt, R; Tang, B; Wolff, M | 1 |
| Bailey, A; DI Maria, M; Howley, LW; Schaffer, MS | 1 |
| Fujimaki, Y; Isose, S; Kanai, K; Kuwabara, S; Misawa, S; Nasu, S; Noto, Y; Sakurai, K; Sekiguchi, Y; Shibuya, K; Yokote, K | 1 |
| Marmura, MJ | 1 |
| Bruno, C; Conte Camerino, D; Costanza, T; Desaphy, JF; Dipalma, A; Franchini, C; George, A; Lentini, G | 1 |
| Anderson, JL; Bair, TL; Bunch, TJ; Crandall, BG; Day, JD; Lappe, DL; Mader, KM; Mahapatra, S; May, HT; Molden, J; Muhlestein, JB; Murdock, D; Osborn, JS; Weiss, JP | 1 |
| Berner, R; Creutzfeldt, R; Hufnagel, M; Jakob, A; Staszewski, O; Winterpacht, A | 1 |
| Hirose, S; Nakazawa, M; Niijima, S; Okumura, A; Shimizu, T; Shimono, K; Yamashita, S | 1 |
| Feige, K; Hoppe, S; Hopster, K; Huber, K; Kietzmann, M; Tappenbeck, K | 1 |
| Clede, L; de la Cuadra-Fontaine, JC; Elgueta, F; Fierro, C; Valderrama, A | 1 |
| Aoki, T; Enomoto, R; Matsuoka, N; Shimoshige, Y; Tsukamoto, M | 1 |
| Osadchii, OE | 1 |
| Lu, K; Lu, Y; Mi, J; Wang, K; Wang, Y | 1 |
| Blinova, K; Chan, D; Crumb, WJ; Erato, C; Florian, J; Guo, P; Hong, M; Johannesen, L; Lin, J; Mason, JW; Mutlib, A; Sanabria, C; Stockbridge, N; Stohlman, J; Strauss, DG; Ugander, M; Vicente, J; Waite-Labott, K; Wang, J | 1 |
| Hosseini, M; Johannesen, L; Mason, JW; Pueyo, E; Sager, PT; Strauss, DG; Vicente, J | 1 |
| Chang, SY; Chen, WC; Yeh, YH | 1 |
| Atayee, RS; Edmonds, KP; Hakim, RC | 1 |
| Bergau, D; Bystricky, W; Carter, D; Gintant, G; Kamradt, K; Maier, C; Welsh, P | 1 |
| Boles, U; Galvin, J; Gul, EE; Keaney, J; Keelan, E; Refila, B; Szeplaki, G | 1 |
| Atayee, RS; Edmonds, KP; Geiger-Hayes, J; Hausdorff, J; Naidu, D; Saphire, ML | 1 |
| Gramlich, D; Heimberger, T; Karck, M; Katus, HA; Lugenbiel, P; Müller, ME; Rahm, AK; Rivinius, R; Ruhparwar, A; Schmack, B; Thomas, D; Ullrich, ND; Uludag, E; Weis, T | 1 |
| Iolascon, G | 1 |
| Senet, P | 1 |
| Deschênes, I; Zheng, Y | 1 |
| Ackerman, MJ; Gao, X; Giudicessi, JR; Kim, M; Shannon, K; Stutzman, MJ; Tester, DJ; Ye, D; Zhou, W | 1 |
40 review(s) available for lidocaine and mexiletine
| Article | Year |
|---|---|
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Models, Molecular; Mutation; Nerve Tissue Proteins; Neuroprotective Agents; Protein Binding; Sodium Channel Blockers; Sodium Channels; Stroke | 2001 |
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship | 2016 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Cardiac arrhythmias - a short review.
Topics: Adrenergic beta-Agonists; Arrhythmias, Cardiac; Digitalis Glycosides; Electric Countershock; Electrocardiography; Humans; Lidocaine; Mexiletine; Pacemaker, Artificial; Phenytoin; Procainamide; Quinidine; Verapamil | 1976 |
Anti-arrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Anesthetics; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Dogs; Humans; Intraoperative Complications; Lidocaine; Mexiletine; Phenytoin; Procainamide; Succinylcholine | 1979 |
The role of antiarrhythmic drugs in prevention of sudden cardiac death.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Death, Sudden; Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Random Allocation; Tocainide | 1985 |
Ventricular arrhythmias. An assessment of newer therapeutic agents.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Flecainide; Humans; Lidocaine; Mexiletine; Tocainide; United States | 1989 |
Class IB antiarrhythmic drugs: tocainide, mexiletine, and moricizine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Tocainide | 1989 |
[The interaction of antiarrhythmic drugs with other drugs].
Topics: Adrenergic beta-Agonists; Amiodarone; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Digoxin; Drug Interactions; Humans; Lidocaine; Mexiletine; Phenytoin; Procainamide; Quinidine | 1985 |
Antiarrhythmic drug therapy. Recent advances and current status.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil | 1985 |
Clinical pharmacology of old and new antiarrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide | 1985 |
Antiarrhythmic drugs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium Channel Blockers; Cell Membrane; Disopyramide; Electrophysiology; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide | 1986 |
Cardiovascular drugs. I: Antidysrhythmic drugs.
Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Cardiovascular Agents; Disopyramide; Drug Interactions; Humans; Kinetics; Lidocaine; Mexiletine; Phenytoin; Procainamide; Tocainide; Verapamil | 1986 |
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment.
Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil | 1986 |
Antiarrhythmic drug therapy of ventricular arrhythmias.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil | 1986 |
Antiarrhythmic agents for chronic ventricular arrhythmias.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Procainamide; Propranolol; Quinidine; Tocainide | 1987 |
Class 1B agents lidocaine, mexiletine, tocainide, phenytoin.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Phenytoin; Tocainide | 1987 |
New antiarrhythmic drugs: tocainide, mexiletine, flecainide, encainide, and amiodarone.
Topics: Administration, Oral; Amiodarone; Anilides; Anti-Arrhythmia Agents; Drug Interactions; Encainide; Flecainide; Heart Conduction System; Humans; Lidocaine; Mexiletine; Tachycardia; Tocainide | 1987 |
Tocainide and mexiletine. Orally effective lidocaine analogues.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Kinetics; Lidocaine; Mexiletine; Propylamines; Tocainide | 1985 |
Antiarrhythmic drug therapy (Part 2). Benefits and hazards.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Propafenone; Propiophenones; Tocainide | 1985 |
[Electrophysiological classification of newer antiarrhythmic drugs (author's transl)].
Topics: Action Potentials; Adrenergic beta-Antagonists; Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Quinidine; Sodium; Tocainide | 1980 |
Antiarrhythmic drug therapy for sustained ventricular tachycardia.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bethanidine; Calcium Channel Blockers; Disopyramide; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Encainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Phenytoin; Piperidines; Procainamide; Quinidine; Tachycardia; Tocainide | 1984 |
[Therapy of cardiac arrhythmias].
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Digitalis Glycosides; Electric Countershock; Electroconvulsive Therapy; Humans; Lidocaine; Mexiletine; Phenytoin | 1984 |
[Medical treatment of extrasystole and tachycardia (author's transl)].
Topics: Action Potentials; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium; Cardiac Complexes, Premature; Digoxin; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Quinidine; Tachycardia; Tachycardia, Paroxysmal; Verapamil | 1980 |
Electropharmacology of antiarrhythmic drugs.
Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Electric Conductivity; Heart Atria; Heart Ventricles; Humans; Lidocaine; Membrane Potentials; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Procainamide; Propranolol; Purkinje Fibers; Quinidine; Tocainide; Verapamil | 1983 |
Hemodynamic effects of antiarrhythmic drugs.
Topics: Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Bretylium Compounds; Calcium Channel Blockers; Disopyramide; Dose-Response Relationship, Drug; Encainide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Myocardial Contraction; Phenytoin; Piperidines; Procainamide; Quinidine; Tocainide | 1983 |
Clinical profiles of newer class I antiarrhythmic agents--tocainide, mexiletine, encainide, flecainide and lorcainide.
Topics: Administration, Oral; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Dose-Response Relationship, Drug; Electrophysiology; Encainide; Flecainide; Hemodynamics; Humans; Injections, Intravenous; Kinetics; Lidocaine; Mexiletine; Piperidines; Tocainide | 1983 |
Therapy with investigational antiarrhythmic drugs.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Tocainide | 1984 |
Comparison of the efficacy of newly developed antiarrhythmic drugs in the treatment of ventricular tachyarrhythmias.
Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Coronary Disease; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Piperidines; Tachycardia; Tocainide; Ventricular Fibrillation | 1984 |
Investigational antiarrhythmic drugs for the treatment of ventricular rhythm disturbances.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Tocainide | 1984 |
[Clinical pharmacology of anti-arrhythymia agents. II. Lignocaine, mexiletine, tocainide, phenytoin].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Kinetics; Lidocaine; Mexiletine; Tocainide | 1981 |
[New antiarrythmic drugs: mexiletine, tocainide, lorcainide, encainide, flecainide, propafenone, cipralan, sotalol].
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Electrophysiology; Encainide; Flecainide; Hemodynamics; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Sotalol; Tocainide | 1982 |
Causes of neuropathic pain.
Topics: Animals; Blood Glucose; Diabetic Neuropathies; Humans; Leg; Lidocaine; Mexiletine; Pain; Regional Blood Flow | 1993 |
Systemic lidocaine for neuropathic pain relief.
Topics: Administration, Oral; Analgesics; Animals; Humans; Lidocaine; Mexiletine; Neuralgia; Sodium Channel Blockers | 2000 |
Systemic administration of local anesthetic agents to relieve neuropathic pain.
Topics: Administration, Oral; Anesthetics, Intravenous; Anesthetics, Local; Flecainide; Humans; Lidocaine; Mexiletine; Nervous System Diseases; Pain; Randomized Controlled Trials as Topic; Tocainide | 2005 |
Systemic administration of local anesthetics to relieve neuropathic pain: a systematic review and meta-analysis.
Topics: Anesthetics, Local; Humans; Lidocaine; Mexiletine; Pain; Peripheral Nervous System Diseases; Randomized Controlled Trials as Topic; Treatment Outcome | 2005 |
Systemic lidocaine or mexiletine for neuropathic pain.
Topics: Administration, Oral; Anesthetics; Evidence-Based Medicine; Humans; Infusions, Intravenous; Lidocaine; Mexiletine; Neuralgia; Practice Guidelines as Topic | 2006 |
Intravenous lidocaine for neuropathic pain: diagnostic utility and therapeutic efficacy.
Topics: Anesthetics, Local; Humans; Infusions, Intravenous; Lidocaine; Mexiletine; Pain; Peripheral Nervous System Diseases | 2007 |
Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias.
Topics: Anesthetics, Local; Humans; Infusions, Intravenous; Lidocaine; Mexiletine; Practice Guidelines as Topic; SUNCT Syndrome; Trigeminal Autonomic Cephalalgias | 2010 |
Is systemic administration of local anesthetic agents effective for relieving neuropathic pain? A Cochrane Review summary with commentary.
Topics: Anesthetics, Local; Humans; Lidocaine; Mexiletine; Neuralgia; Randomized Controlled Trials as Topic; Treatment Outcome | 2020 |
30 trial(s) available for lidocaine and mexiletine
| Article | Year |
|---|---|
Side-effects of mexiletene.
Topics: Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Propylamines | 1978 |
The role of antiarrhythmic drugs in prevention of sudden cardiac death.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Death, Sudden; Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Random Allocation; Tocainide | 1985 |
[Combination of sotalol with the class I B substances mexiletine or tocainide in complex ventricular extrasystole].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Sotalol; Tocainide | 1987 |
Mexiletine and tocainide: a comparison of antiarrhythmic efficacy, adverse effects, and predictive value of lidocaine testing.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Drug Evaluation; Drug Resistance; Drug Therapy, Combination; Electric Stimulation; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Prospective Studies; Quinidine; Random Allocation; Tocainide | 1989 |
Chronic pain treatment with intravenous lidocaine.
Topics: Double-Blind Method; Humans; Infusions, Intravenous; Lidocaine; Mexiletine; Nervous System Diseases; Pain Measurement; Pain, Intractable | 1986 |
Electrophysiologic testing of tocainide and mexiletine for ventricular tachycardia: assessment of the need to test both drugs.
Topics: Drug Evaluation; Heart Ventricles; Humans; Lidocaine; Mexiletine; Prospective Studies; Tachycardia; Tocainide | 1986 |
Comparison of intravenous mexiletine and lidocaine for the treatment of ventricular arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Drug Evaluation; Electrocardiography; Female; Heart Ventricles; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Random Allocation; Time Factors | 1986 |
Dercum's disease (adiposis dolorosa). Treatment of the severe pain with intravenous lidocaine.
Topics: Adiposis Dolorosa; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Mexiletine; Pain | 1987 |
[Comparative study of the anti-arrhythmic activity of mexiletine and lidocaine in ventricular hyperkinetic arrhythmias].
Topics: Aged; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Propylamines; Tachycardia | 1981 |
Selection of an antiarrhythmic drug for a sudden-death-prevention trial.
Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Compounds; Clinical Trials as Topic; Death, Sudden; Encainide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Moricizine; Morpholines; Phenothiazines; Piperidines; Tocainide; Verapamil | 1982 |
[Hemodynamic effects of mexiletine and lidocaine in coronary surgery patients].
Topics: Cardiac Surgical Procedures; Female; Hemodynamics; Humans; Lidocaine; Mexiletine; Postoperative Period; Propylamines | 1983 |
[The effect of anti-arrhythmic drugs on myocardial function (author's transl)].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Disease; Depression, Chemical; Disopyramide; Echocardiography; Humans; Lidocaine; Mexiletine; Middle Aged; Myocardial Contraction; Placebos; Propafenone; Propiophenones; Tocainide | 1982 |
Mexiletine in clinical practice.
Topics: Acute Disease; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Propylamines | 1980 |
Disopyramide and mexiletine: which is the agent of choice in the long term-oral treatment of lidocaine-responsive arrhythmias? Efficacy comparison in a randomized trial.
Topics: Arrhythmias, Cardiac; Clinical Trials as Topic; Disopyramide; Electrocardiography; Humans; Lidocaine; Mexiletine; Propylamines; Pyridines; Random Allocation | 1980 |
Mexiletine vs. lignocaine in the management of ventricular arrhythmias after open-heart surgery.
Topics: Arrhythmias, Cardiac; Cardiac Surgical Procedures; Clinical Trials as Topic; Female; Heart Ventricles; Humans; Infant, Newborn; Lidocaine; Male; Mexiletine; Middle Aged; Propylamines; Random Allocation | 1982 |
[Hemodynamic effects of lidocaine and mexiletine in acute heart infarction].
Topics: Acute Disease; Female; Hemodynamics; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propylamines | 1982 |
Kinetics of frequency-dependent conduction delay by class I antiarrhythmic drugs in human atrium.
Topics: Anti-Arrhythmia Agents; Aprindine; Cardiac Pacing, Artificial; Disopyramide; Electrophysiology; Female; Heart Atria; Heart Conduction System; Humans; Kinetics; Lidocaine; Male; Mexiletine; Middle Aged; Sodium Channels | 1995 |
Systemic lidocaine therapy for poststroke pain.
Topics: Adult; Aged; Algorithms; Cerebrovascular Disorders; Drug Monitoring; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Injections, Intravenous; Lidocaine; Male; Mexiletine; Pain Measurement; Pain, Intractable; Retrospective Studies | 1993 |
Response to intravenous lidocaine infusion predicts subsequent response to oral mexiletine: a prospective study.
Topics: Administration, Oral; Adult; Aged; Anesthetics, Local; Anti-Arrhythmia Agents; Double-Blind Method; Female; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged; Neuralgia; Prognosis; Prospective Studies | 1996 |
Intravenous lidocaine and oral mexiletine block reflex bronchoconstriction in asthmatic subjects.
Topics: Adult; Anesthetics, Local; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Histamine; Humans; Lidocaine; Male; Mexiletine; Premedication; Prospective Studies; Reflex; Vagus Nerve | 1996 |
Mexiletine in the treatment of spasmodic torticollis.
Topics: Administration, Oral; Adult; Analysis of Variance; Anesthetics, Local; Dystonia; Electromyography; Female; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged; Surveys and Questionnaires; Torticollis | 1998 |
Positive symptoms in multiple sclerosis: their treatment with sodium channel blockers, lidocaine and mexiletine.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Multiple Sclerosis; Pain; Seizures; Sodium Channel Blockers | 1999 |
[Clinical applications and the effect of mexiletine on refractory epilepsies].
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Lidocaine; Male; Mexiletine; Time Factors | 2000 |
Systemic lidocaine in pain due to peripheral nerve injury and predictors of response.
Topics: Adult; Aged; Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temperature; Humans; Hyperalgesia; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged; Neuralgia; Pain; Pain Threshold; Peripheral Nerve Injuries; Physical Stimulation; Sensory Thresholds; Touch; Treatment Outcome | 2004 |
Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.
Topics: Aged; Anti-Asthmatic Agents; Chronic Disease; Disopyramide; Exercise; Exercise Test; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Radionuclide Imaging; Tachycardia, Ventricular; Treatment Outcome; Ventricular Dysfunction, Left | 2004 |
The effect of intravenously administered mexiletine on tinnitus - a pilot study.
Topics: Adult; Anesthetics, Local; Anti-Arrhythmia Agents; Female; Humans; Injections, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged; Otoacoustic Emissions, Spontaneous; Pilot Projects; Reflex, Acoustic; Severity of Illness Index; Stapedius; Tinnitus; Treatment Outcome | 2006 |
Differential contribution of sodium channel subtypes to action potential generation in unmyelinated human C-type nerve fibers.
Topics: Action Potentials; Anesthetics, Local; Anti-Arrhythmia Agents; Electric Stimulation; Electrophysiology; Humans; In Vitro Techniques; Lidocaine; Membrane Potentials; Mexiletine; Nerve Fibers, Unmyelinated; Sensory Thresholds; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2007 |
Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial.
Topics: Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Drug Therapy, Combination; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; Heart Rate; Humans; Lidocaine; Long QT Syndrome; Male; Mexiletine; Moxifloxacin; Phenethylamines; Prospective Studies; Sodium Channel Blockers; Sulfonamides; Young Adult | 2016 |
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.
Topics: Adult; Biomarkers; Calcium Channel Blockers; Cross-Over Studies; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Heart; Heart Rate; Humans; Lidocaine; Long QT Syndrome; Male; Mexiletine; Phenethylamines; Potassium Channel Blockers; Sodium; Sodium Channel Blockers; Sulfonamides; Torsades de Pointes; Verapamil | 2016 |
T vector velocity: A new ECG biomarker for identifying drug effects on cardiac ventricular repolarization.
Topics: Action Potentials; Adult; Databases, Factual; Double-Blind Method; Electrocardiography; Female; Heart; Humans; Lidocaine; Male; Mexiletine; Phenethylamines; Potassium Channel Blockers; Ranolazine; Sodium Channel Blockers; Sulfonamides; Verapamil; Young Adult | 2019 |
184 other study(ies) available for lidocaine and mexiletine
| Article | Year |
|---|---|
New antiarrhythmic agents. 2,2,5,5-Tetramethyl-3-pyrroline-3-carboxamides and 2,2,5,5-tetramethylpyrrolidine-3-carboxamindes.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Evaluation, Preclinical; Indicators and Reagents; Magnetic Resonance Spectroscopy; Nicotine; Ouabain; Rats; Spectrophotometry, Infrared; Structure-Activity Relationship | 1986 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
5,7,8-Trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury.
Topics: Action Potentials; Amides; Animals; Anti-Arrhythmia Agents; Antioxidants; Benzopyrans; Benzoxazines; Female; Heart; Lipid Peroxidation; Male; Myocardial Reperfusion Injury; Papillary Muscles; Rabbits; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.
Topics: Animals; Anti-Arrhythmia Agents; Aorta; Ataxia; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Caco-2 Cells; Guinea Pigs; Heart; Heart Rate; HEK293 Cells; Humans; Ion Channel Gating; Mexiletine; Mice; NAV1.5 Voltage-Gated Sodium Channel; Permeability; Sodium Channels; Stereoisomerism; Vasodilator Agents | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
[Drug therapy of tachyarrhythmias (author's transl)].
Topics: Action Potentials; Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Tachycardia; Verapamil | 1978 |
Newer antiarrhythmic drugs.
Topics: Administration, Oral; Adult; Amiodarone; Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Child; Edrophonium; Electrophysiology; Heart Conduction System; Heart Ventricles; Humans; Injections, Intravenous; Lidocaine; Mexiletine; Recurrence; Tachycardia; Tocainide; Verapamil; Wolff-Parkinson-White Syndrome | 1978 |
[Effects of mexiletine and lidocaine on myocardial performance in heart disease patients in various functional classes].
Topics: Adult; Arrhythmias, Cardiac; Cardiac Output; Coronary Disease; Heart Diseases; Heart Rate; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Contraction; Myocardial Infarction; Propylamines; Systole | 1978 |
The treatment of ventricular arrhythmias in acute myocardial infarction.
Topics: Anti-Arrhythmia Agents; Electric Countershock; Electrocardiography; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Procainamide; Time Factors; Ventricular Fibrillation | 1979 |
Simple gas-liquid chromatographic method for the measurement of mexiletine and lignocaine in blood-plasma or serum.
Topics: Chromatography, Gas; Humans; Lidocaine; Mexiletine; Microchemistry; Propylamines; Structure-Activity Relationship | 1979 |
Mexiletine in the management of ventricular dysrhythmias.
Topics: Administration, Oral; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Resistance; Humans; Injections, Intravenous; Lidocaine; Mexiletine; Middle Aged; Propylamines | 1977 |
Antiarrhythmic drugs: clinical pharmacology and therapeutic uses.
Topics: Acebutolol; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bretylium Compounds; Digitalis Glycosides; Disopyramide; Humans; Kinetics; Lidocaine; Mexiletine; Oxytocin; Phenytoin; Procainamide; Propranolol; Quinidine; Verapamil | 1978 |
New antiarrhythmic drugs.
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Papaverine; Phenothiazines | 1978 |
Mexiletine in isolated tissue models.
Topics: Action Potentials; Animals; Depression, Chemical; In Vitro Techniques; Lidocaine; Membrane Potentials; Mexiletine; Myocardial Contraction; Propylamines; Purkinje Fibers; Rabbits | 1977 |
Comparison of the effects of lignocaine and mexiletine on experimental ventricular arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Dogs; Lidocaine; Mexiletine; Propylamines; Tachycardia; Ventricular Fibrillation | 1977 |
The effect of mexiletine on left ventricular ejection: a comparison with lignocaine and propranolol.
Topics: Heart; Heart Ventricles; Humans; Lidocaine; Mexiletine; Physical Exertion; Propranolol; Propylamines | 1977 |
Prevention of ventricular arrhythmias after myocardial infarction.
Topics: Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Procainamide; Propranolol; Quinidine; Ventricular Fibrillation | 1977 |
Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs.
Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Dinitrophenols; Disopyramide; Flecainide; Glyburide; Guinea Pigs; Heart Ventricles; Imidazoles; Lidocaine; Mexiletine; Myocardium; Piperidines; Potassium; Procainamide; Pyridines | 1992 |
[Pharmacokinetics and pharmacodynamics of class I antiarrhythmic agents after a single oral administration].
Topics: Administration, Oral; Anti-Arrhythmia Agents; Aprindine; Flecainide; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone | 1992 |
Effects of sympathetic stimulation on use dependence of lidocaine, mexiletine, and quinidine in an intact canine model.
Topics: Action Potentials; Animals; Chromatography, High Pressure Liquid; Dogs; Electric Stimulation; Female; Heart Conduction System; In Vitro Techniques; Lidocaine; Male; Mexiletine; Quinidine; Sodium Channels; Stellate Ganglion; Sympathetic Nervous System | 1992 |
Combined class I antiarrhythmic agents have differential effects on tonic and use dependent block of maximum rate of depolarisation of action potentials in guinea pig cardiac muscle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aprindine; Disopyramide; Drug Combinations; Guinea Pigs; Lidocaine; Mexiletine; Myocardium; Quinidine; Sodium Channels | 1992 |
[Clinical significance of the use-dependent sodium channel block and reverse use-dependent potassium channel block of class I and class III antiarrhythmic agents and their values to predict drug efficacy].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Electrophysiology; Exercise Test; Humans; Lidocaine; Mexiletine; Middle Aged; Potassium Channels; Sodium Channels | 1992 |
[Estimation of depressant effects of class I antiarrhythmic drugs on intraventricular conduction--rate-dependent effects on QRS duration].
Topics: Anti-Arrhythmia Agents; Aprindine; Depression, Chemical; Disopyramide; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Humans; Lidocaine; Mexiletine; Sodium Channels; Ventricular Function | 1992 |
Toxicity potential of oral lidocaine in a patient receiving mexiletine.
Topics: Administration, Oral; Cardiomyopathy, Dilated; Central Nervous System; Female; Humans; Lidocaine; Mexiletine; Middle Aged | 1992 |
A combination of inactivated sodium channel blockers causes competitive interaction on dV/dtmax of single ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Cells, Cultured; Guinea Pigs; Heart; Ion Channel Gating; Lidocaine; Membrane Potentials; Mexiletine; Sodium Channels | 1991 |
[Treatment of pain in diabetic polyneuropathy].
Topics: Analgesics; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Carbamazepine; Diabetic Neuropathies; Gangliosides; Humans; Lidocaine; Linolenic Acids; Mexiletine; Pain | 1991 |
Liquid chromatographic analysis of mexiletine in serum, with alternate application to tocainide, procainamide, and N-acetylprocainamide.
Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Lidocaine; Mexiletine; Procainamide; Tocainide | 1991 |
The management of oral mexiletine and intravenous lidocaine to treat chronic painful symmetrical distal diabetic neuropathy.
Topics: Chronic Disease; Diabetic Neuropathies; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Lidocaine; Mexiletine; Middle Aged; Pain; Pain Measurement | 1991 |
Antiarrhythmic and cardiovascular profiles of the fused indole compound (3aR,12R,12aR,12bS)-12-amino-2,3,3a,4,11,12,12a,12b-octahydro-10-hydrox yisoquino [2,1,8-lma]carbazol-5(1H)-one hydrochloride 1.5 hydrate.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carbazoles; Chloroform; Disopyramide; Dogs; Female; Flecainide; Heart; Heart Conduction System; Hemodynamics; Isoquinolines; Lidocaine; Male; Mexiletine; Mice; Mice, Inbred ICR; Myocardial Contraction; Ouabain | 1991 |
Neuropathic pain can be relieved by drugs that are use-dependent sodium channel blockers: lidocaine, carbamazepine, and mexiletine.
Topics: Adult; Aged; Carbamazepine; Female; Humans; Lidocaine; Male; Mexiletine; Neuralgia; Peripheral Nerve Injuries; Sodium Channels | 1991 |
[Primary research on the clinical significance of ventricular late potentials (VLPs), and the impact of mexiletine, lidocaine and Astragalus membranaceus on VLPs].
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Astragalus propinquus; Drugs, Chinese Herbal; Electrocardiography, Ambulatory; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Myocarditis | 1991 |
Vascular effects of lignocaine after coronary artery surgery.
Topics: Coronary Artery Bypass; Drug Evaluation; Humans; Lidocaine; Mexiletine; Muscle Contraction; Phenytoin; Saphenous Vein; Tachycardia | 1990 |
Reversed-phase LC resolutions of chiral antiarrhythmic agents via derivatization with homochiral isothiocyanates.
Topics: Anti-Arrhythmia Agents; Chromatography, Liquid; Flecainide; Humans; Indicators and Reagents; Lidocaine; Male; Mexiletine; Propafenone; Thiocyanates; Tocainide | 1990 |
Mexiletine add-on therapy for treatment of intractable epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Status Epilepticus | 1990 |
[Acute myocardial uptake of lidocaine, mexiletine and amiodarone].
Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiac Catheterization; Coronary Disease; Humans; Injections, Intravenous; Lidocaine; Mexiletine; Myocardium; Time Factors | 1990 |
Antiarrhythmic drugs. Clinical pharmacology of the old and the new agents.
Topics: Acecainide; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden; Delayed-Action Preparations; Disopyramide; Heart Arrest; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Procainamide; Resuscitation; Tocainide | 1985 |
Comparison of the inhibitory effects of mexiletine and lidocaine on the calcium current of single ventricular cells.
Topics: Action Potentials; Animals; Calcium; Guinea Pigs; Heart; Ion Channels; Lidocaine; Mexiletine; Sodium; Ventricular Function | 1986 |
Effect of SUN 1165, a new potent antiarrhythmic agent, on the kinetics of rate-dependent block of Na channels and ventricular conduction of extrasystoles.
Topics: Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Cardiac Complexes, Premature; Disopyramide; Guinea Pigs; Heart Conduction System; Heart Ventricles; In Vitro Techniques; Ion Channels; Lidocaine; Male; Mexiletine; Papillary Muscles; Piperidines; Sodium | 1988 |
Combination antiarrhythmic therapy for management of malignant ventricular arrhythmia.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Quinidine; Tachycardia; Tocainide | 1988 |
Effects of antiarrhythmic drugs on the repetitive extrasystole threshold and the ventricular fibrillation threshold.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Disopyramide; Dogs; Heart; Lidocaine; Mexiletine; Procainamide; Ventricular Fibrillation | 1989 |
Lidocaine & tocainide & mexiletine.
Topics: Drug Interactions; Humans; Lidocaine; Mexiletine; Tocainide | 1989 |
Congestive heart failure induced by six of the newer antiarrhythmic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Encainide; Female; Heart Failure; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Moricizine; Phenothiazines; Piperidines; Propafenone; Risk Factors; Stroke Volume; Tocainide | 1989 |
The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Injections, Intravenous; Lidocaine; Male; Mexiletine; Neural Conduction; Neuroma; Rats; Rats, Inbred Strains; Sciatic Nerve; Stress, Mechanical; Tocainide | 1989 |
Lidocaine, mexiletine and propafenone in the treatment of arrhythmias complicating myocardial infarction. A case report.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Heart Atria; Heart Ventricles; Hemodynamics; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propafenone; Propiophenones; Propylamines; Tachycardia | 1985 |
Prediction of acute myocardial disposition of antiarrhythmic drugs.
Topics: Anti-Arrhythmia Agents; Humans; Lidocaine; Mexiletine; Models, Biological; Myocardium | 1989 |
Frequency-dependent antiarrhythmic drug effects on postrepolarization refractoriness and ventricular conduction time in canine ventricular myocardium in vivo.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Female; Heart; Heart Conduction System; Heart Ventricles; Lidocaine; Male; Mexiletine; Quinidine | 1989 |
[2 cases of lidocaine-resistant ventricular tachycardia treated with i.v. mexiletine during complicated acute myocardial infarct].
Topics: Aged; Aged, 80 and over; Drug Resistance; Electrocardiography; Female; Heart Ventricles; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Myocardial Infarction; Tachycardia | 1987 |
Mexiletine and tocainide: does response to one predict response to the other?
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electric Stimulation; Electrocardiography; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Propylamines; Stroke Volume; Tachycardia; Tocainide; Ventricular Fibrillation | 1986 |
[Hemodynamic repercussions and clinical tolerance of 6 class I anti-arrhythmia agents in acute myocardial infarction].
Topics: Ajmaline; Anti-Arrhythmia Agents; Benzeneacetamides; Fluorenes; Hemodynamics; Lidocaine; Mexiletine; Myocardial Infarction; Piperidines; Tocainide | 1986 |
Second generation antiarrhythmic agents: have we reached antiarrhythmic Nirvana?
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Tocainide | 1987 |
Mexitil and cross-allergenicity.
Topics: Cross Reactions; Humans; Lidocaine; Mexiletine; Tocainide | 1987 |
Efficacy of class Ib (lidocaine-like) antiarrhythmic agents for prevention of sustained ventricular tachycardia secondary to coronary artery disease.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Disease; Electrophysiology; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Procainamide; Tachycardia; Tocainide; Ventricular Fibrillation | 1987 |
Use-dependent blocking action of newly developed lidocaine-analogs on maximum rate of rise of action potentials in guinea pig papillary muscle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Guinea Pigs; Kinetics; Lidocaine; Mexiletine; Papillary Muscles; Structure-Activity Relationship; Tocainide | 1987 |
Mexiletine and tocainide: a profile of two lidocaine analogs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Heart; Humans; In Vitro Techniques; Lidocaine; Mexiletine; Tocainide | 1987 |
Action of tocainide and mexiletine on the excitation threshold of myelinated nerves.
Topics: Action Potentials; Animals; Electrophysiology; In Vitro Techniques; Lidocaine; Membrane Potentials; Mexiletine; Myelin Sheath; Nerve Fibers; Rana esculenta; Sodium; Tocainide | 1987 |
Prediction of efficacy and tolerance of oral mexiletine by intravenous lidocaine application.
Topics: Administration, Oral; Adult; Aged; Arrhythmias, Cardiac; Female; Humans; Injections, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged | 1988 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Temperature; Catalepsy; Cats; Central Nervous System; Chemical Phenomena; Chemistry; Disopyramide; Dogs; Electroencephalography; Female; Hypothermia; Lidocaine; Male; Mexiletine; Mice; Motor Activity; Muscle Relaxation; Pain; Rabbits; Rats; Rats, Inbred Strains; Seizures; Tremor; Vomiting | 1988 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 2nd communication: effect on the peripheral nervous system and peripheral organs.
Topics: Animals; Anti-Arrhythmia Agents; Autonomic Nervous System; Capillary Permeability; Chemical Phenomena; Chemistry; Digestive System; Disopyramide; Endocrine Glands; Female; Gastric Mucosa; Gastrointestinal Motility; Guinea Pigs; Ileum; Lidocaine; Male; Mexiletine; Mice; Peripheral Nerves; Pregnancy; Pupil; Rabbits; Rats; Rats, Inbred Strains; Trachea; Urinary Bladder; Urogenital System; Uterus; Vas Deferens | 1988 |
Recovery from use-dependent block of Vmax and restitution of action potential duration in canine cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Disopyramide; Dogs; Electrophysiology; Heart Conduction System; Lidocaine; Mexiletine; Microelectrodes; Purkinje Fibers; Sodium; Tetrodotoxin | 1988 |
Relationship between use-dependent effects of antiarrhythmic drugs on conduction and Vmax in canine cardiac Purkinje fibers.
Topics: Action Potentials; Amitriptyline; Anesthesia, Local; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; Heart Conduction System; Kinetics; Lidocaine; Mexiletine; Microelectrodes; Procainamide; Purkinje Fibers | 1987 |
Pharmacological investigation of a new anti-arrhythmic agent, GYKI-23 107.
Topics: Aconitum; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Chemical Phenomena; Chemistry; Dogs; Female; Hemodynamics; Lidocaine; Male; Mexiletine; Mice; Ouabain; Propylamines; Rats | 1987 |
Estimates of the population pharmacokinetic parameters and performance of Bayesian feedback: a sensitivity analysis.
Topics: Bayes Theorem; Lidocaine; Mexiletine; Models, Biological; Monte Carlo Method; Pharmaceutical Preparations; Pharmacokinetics; Probability | 1987 |
Short-term myocardial uptake of lidocaine and mexiletine in patients with ischemic heart disease.
Topics: Adult; Aged; Blood Flow Velocity; Cardiac Catheterization; Coronary Circulation; Coronary Disease; Female; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Male; Mexiletine; Middle Aged; Myocardium; Propylamines | 1986 |
An experimental approach to the choice of antiarrhythmic therapy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil | 1986 |
Effect of mexiletine on reperfusion-induced ventricular arrhythmias: comparison with lidocaine.
Topics: Animals; Arrhythmias, Cardiac; Constriction; Coronary Circulation; Coronary Vessels; Dogs; Female; Hemodynamics; Lidocaine; Male; Mexiletine | 1986 |
[Effects of antiarrhythmic drugs on rat erythrocytes, isolated hepatocytes and dipalmitoyl phosphatidyl choline (DPPC)-liposomes].
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Cell Membrane; Erythrocyte Membrane; Hemolysis; In Vitro Techniques; Lidocaine; Liposomes; Liver; Male; Mexiletine; Pulmonary Surfactants; Rats; Rats, Inbred Strains | 1985 |
The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of paroxysmal tachycardias.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathies; Chromatography, High Pressure Liquid; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propafenone; Propiophenones; Quinidine; Tachycardia, Paroxysmal; Time Factors; Tocainide; Verapamil | 1985 |
Haemodynamic effects of class I antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Disopyramide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide | 1985 |
Liquid chromatographic determination of mexiletine and tocainide in human plasma with fluorescence detection after reaction with a modified o-phthalaldehyde reagent.
Topics: Chromatography, Liquid; Drug Stability; Humans; Lidocaine; Mexiletine; o-Phthalaldehyde; Propylamines; Spectrometry, Fluorescence; Tocainide | 1985 |
[Anti-arrhythmia agents (II): Mexiletine, aprindine, tocainide and amiodarone].
Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Humans; Lidocaine; Mexiletine; Tocainide | 1985 |
Comparative electropharmacology of mexiletine, lidocaine and quinidine in a canine Purkinje fiber model.
Topics: Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Electric Conductivity; Heart; In Vitro Techniques; Lidocaine; Membrane Potentials; Mexiletine; Propylamines; Purkinje Fibers; Quinidine; Sodium; Time Factors | 1986 |
The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Disease Models, Animal; Electrocardiography; Hemodynamics; Lidocaine; Mexiletine; Prazosin; Propranolol; Stellate Ganglion | 1985 |
[Ventricular fibrillation caused by myocardial infarction refractory to electric shock and xylocaine. Positive response to intravenous mexiletine].
Topics: Electric Countershock; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propylamines; Ventricular Fibrillation | 1985 |
Inhibition of sympathetic nervous system by mexiletine, an antiarrhythmic agent, and its antagonism against ouabain.
Topics: Animals; Aorta, Thoracic; Arrhythmias, Cardiac; Electric Stimulation; Epinephrine; Guinea Pigs; In Vitro Techniques; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle, Smooth, Vascular; Nicotine; Norepinephrine; Ouabain; Portal Vein; Potassium Chloride; Propylamines; Pulmonary Artery; Rabbits; Rats; Rats, Inbred Strains; Sympatholytics; Tyramine | 1985 |
New drugs in the management of ventricular arrhythmias.
Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Compounds; Drug Interactions; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Propafenone; Propiophenones; Tocainide | 1984 |
Drugs and the heart. IV. Antiarrhythmic agents.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Heart Conduction System; Hemodynamics; Humans; Lidocaine; Mexiletine; Procainamide; Quinidine; Verapamil | 1980 |
The antifibrillatory potency of aprindine, mexiletine, tocainide and lignocaine compared on Langendorff-perfused hearts of rabbits and guinea-pigs.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; In Vitro Techniques; Indenes; Lidocaine; Male; Mexiletine; Ouabain; Perfusion; Propylamines; Rabbits; Tocainide; Ventricular Fibrillation | 1980 |
Antiarrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil | 1983 |
New directions in antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil | 1984 |
[Oral maintenance treatment with mexiletine after acute administration of xilocaine (author's transl)].
Topics: Administration, Oral; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Female; Humans; Injections, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged; Propylamines; Tachycardia, Paroxysmal | 1981 |
Antiarrhythmic therapy: new additions and future expectations.
Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Bretylium Tosylate; Disopyramide; Encainide; Humans; Lidocaine; Mexiletine; Tocainide; Verapamil | 1983 |
[Drug therapy of arrhythmia in coronary cardiopathy].
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Cardiac Complexes, Premature; Coronary Disease; Disopyramide; Electrocardiography; Humans; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Tachycardia; Tocainide | 1983 |
Depressant effects of drugs used in myotonia therapy.
Topics: Animals; In Vitro Techniques; Ion Channels; Lidocaine; Mexiletine; Muscle Contraction; Myotonia; Phenytoin; Procainamide; Quinidine; Rana catesbeiana; Tocainide | 1982 |
In vivo and in vitro studies on the effect of sodium antagonists on the bladder in man and rat.
Topics: Adult; Aged; Animals; Dose-Response Relationship, Drug; Female; Humans; Ion Channels; Lidocaine; Male; Mexiletine; Middle Aged; Muridae; Muscle Contraction; Propylamines; Urinary Bladder; Urinary Incontinence | 1983 |
The amino acid cerebral pool after toxic doses of lidocaine and mexiletine. An experimental study on guinea pigs.
Topics: Amino Acids; Ammonia; Animals; Brain Chemistry; Guinea Pigs; Lidocaine; Mexiletine; Propylamines | 1984 |
Acute effects of anti-arrhythmic drugs on cardiac pacing threshold.
Topics: Adult; Aged; Ajmaline; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrophysiology; Female; Heart; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Propranolol; Verapamil | 1984 |
Molecular basis for the antigenicity of lidocaine analogs: tocainide and mexiletine.
Topics: Aged; Anti-Arrhythmia Agents; Antigens; Cross Reactions; Drug Hypersensitivity; Female; Humans; Intradermal Tests; Lidocaine; Mexiletine; Propylamines; Structure-Activity Relationship; Tocainide | 1984 |
Nursing care for survivors of sudden cardiac death.
Topics: Adaptation, Psychological; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Heart Arrest; Heart Conduction System; Humans; Lidocaine; Mexiletine; Moricizine; Nursing Assessment; Phenothiazines; Tocainide | 1984 |
Drug therapy of cardiac arrhythmias.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Biological Availability; Encainide; Half-Life; Humans; Imidazoles; Intestinal Absorption; Kinetics; Lidocaine; Metabolic Clearance Rate; Mexiletine; Propafenone; Propiophenones; Protein Binding; Tachycardia; Tocainide | 1983 |
Experience with NONMEM: analysis of serum concentration data in patients treated with mexiletine and lidocaine.
Topics: Computers; Female; Humans; Kinetics; Lidocaine; Male; Mexiletine; Models, Biological; Propylamines; Software | 1984 |
[Effect of membrane-effective drugs (anti-arrhythmia agents) on acoustically evoked brain-stem potentials].
Topics: Animals; Anti-Arrhythmia Agents; Audiometry; Audiometry, Evoked Response; Lidocaine; Mexiletine; Phenytoin; Procainamide; Rabbits | 1984 |
Mexiletine in lidocaine-resistant ventricular tachycardia.
Topics: Heart Ventricles; Humans; Lidocaine; Mexiletine; Propylamines; Tachycardia | 1984 |
[Cholestatic hepatitis during treatment with mexiletine/lidocaine].
Topics: Cholestasis, Intrahepatic; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Propylamines | 1984 |
Clinical pharmacology of antiarrhythmic drugs: a review and overview, part II.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Humans; Kinetics; Lidocaine; Mexiletine; Phenytoin; Procainamide; Propranolol; Tocainide | 1981 |
Advances in antiarrhythmic therapy. The role of newer antiarrhythmic drugs.
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Atrioventricular Node; Humans; Lidocaine; Mexiletine; Tocainide; Verapamil | 1982 |
[Determination of plasma concentrations of anti-arrhythmia agents].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biological Availability; Disopyramide; Dose-Response Relationship, Drug; Humans; Lidocaine; Mexiletine; Procainamide; Propranolol; Quinidine | 1981 |
Tocainide--an alternative to mexiletine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Tocainide | 1982 |
Availability of electrophysiological approach to the selection and assessment of antiarrhythmic drugs for recurrent ventricular tachycardia.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Procainamide; Recurrence; Tachycardia; Verapamil | 1983 |
Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations.
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Dogs; Female; Lidocaine; Male; Mexiletine; Phenytoin; Verapamil | 1983 |
Intravenous mexiletine in management of lidocaine-resistant ventricular tachycardia.
Topics: Adult; Drug Resistance; Female; Humans; Injections, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propylamines; Tachycardia | 1983 |
Intropic effects of several antiarrhythmic drugs.
Topics: Ajmaline; Anti-Arrhythmia Agents; Aprindine; Blood Pressure; Bunaftine; Coronary Disease; Disopyramide; Heart Rate; Hemodynamics; Humans; Lidocaine; Mexiletine; Middle Aged; Myocardial Contraction; Phenytoin; Procainamide | 1983 |
[Comparative haemodynamic studies with mexiletine and lidocaine in patients with coronary heart disease after aorto-coronary bypass (author's transl)].
Topics: Cardiac Output; Coronary Artery Bypass; Coronary Disease; Hemodynamics; Humans; Lidocaine; Mexiletine; Propylamines; Stroke Volume; Time Factors; Vascular Resistance | 1981 |
[Mexiletine in the treatment of lidocaine-resistant ventricular tachycardia. Preliminary results].
Topics: Drug Resistance; Female; Humans; Lidocaine; Male; Mexiletine; Myocardial Infarction; Propylamines; Tachycardia; Tachycardia, Paroxysmal | 1982 |
[Antiarrhythmic treatment with mexiletine in acute myocardial infarction (author's transl)].
Topics: Aged; Arrhythmias, Cardiac; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propylamines | 1981 |
Recurrence of ventricular fibrillation in acute ischemic heart disease.
Topics: Acute Disease; Anti-Arrhythmia Agents; Coronary Disease; Female; Heart Arrest; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Quinidine; Recurrence; Resuscitation; Ventricular Fibrillation | 1981 |
[Efficacy of disopyramide and mexiletine per os in the chronic treatment of ventricular arrhythmias sensitive to lidocaine].
Topics: Arrhythmias, Cardiac; Disopyramide; Humans; Lidocaine; Mexiletine; Middle Aged; Propylamines; Pyridines | 1981 |
[The plasma concentration measurement of local anesthetics, thiobarbiturates and mexiletine by HPLC with automatic pre-treatment system].
Topics: Anesthetics, Intravenous; Anesthetics, Local; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Lidocaine; Mepivacaine; Mexiletine; Reproducibility of Results; Thiobarbiturates | 1995 |
Prevention of bronchoconstriction by an orally active local anesthetic.
Topics: Animals; Bronchi; Bronchoconstriction; Bronchography; Dogs; Histamine; Lidocaine; Mexiletine; Tomography, X-Ray Computed | 1995 |
Mexiletine and lidocaine reduce post-ischemic functional and biochemical dysfunction of perfused hearts.
Topics: Adenosine Triphosphate; Animals; Calcium; Creatine Kinase; Lidocaine; Mexiletine; Myocardial Contraction; Myocardial Ischemia; Myocardium; Perfusion; Potassium; Rats; Rats, Wistar; Sodium | 1995 |
Characterization of the independent and combined effects of two inhibitors on oxidative drug metabolism in rat liver microsomes.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cimetidine; Kinetics; Lidocaine; Male; Mexiletine; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 1995 |
Predicting the hepatic clearance of xenobiotics in humans from in vitro data.
Topics: Biological Availability; Chlorzoxazone; Cytochrome P-450 Enzyme System; Humans; Hydrocortisone; Lidocaine; Liver; Mathematics; Metabolic Clearance Rate; Mexiletine; Nifedipine; Predictive Value of Tests; Rifampin; Xenobiotics | 1994 |
[Intravenous lidocaine in the treatment of post treatment neuropathy].
Topics: Administration, Oral; Aged; Diabetes Mellitus; Diabetic Neuropathies; Drug Therapy, Combination; Humans; Injections, Intravenous; Insulin; Lidocaine; Male; Mexiletine; Sensation Disorders | 1994 |
Neurotoxicity of lidocaine combined with mexiletine.
Topics: Administration, Oral; Cardiomyopathies; Drug Therapy, Combination; Humans; Injections, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged; Nervous System Diseases; Tachycardia, Ventricular | 1993 |
Clinical evaluation of the use-dependent QRS prolongation and the reverse use-dependent QT prolongation of class I and class III antiarrhythmic agents and their value in predicting efficacy.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Exercise Test; Female; Heart Rate; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Piperidines; Potassium Channels; Pyridines; Sodium Channels | 1993 |
Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disopyramide; Electrocardiography; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Procainamide; Syndrome; Tachycardia, Ventricular; Verapamil | 1996 |
Temporomandibular joint pain as a neuropathy.
Topics: Administration, Oral; Drug Therapy, Combination; Facial Pain; Humans; Injections, Intravenous; Lidocaine; Mexiletine; Peripheral Nervous System Diseases; Temporomandibular Joint Dysfunction Syndrome | 1995 |
Relative potency of mexiletine, lidocaine, and tocainide as inhibitors of rat liver CYP1A1 activity.
Topics: Animals; Anti-Arrhythmia Agents; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Immunoblotting; In Vitro Techniques; Kinetics; Lidocaine; Male; Mexiletine; Microsomes, Liver; Oxidoreductases; Rats; Rats, Sprague-Dawley; Tocainide | 1995 |
[Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures].
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Seizures; Status Epilepticus | 1997 |
Effects of blockade of fast and slow inward current channels on ventricular fibrillation in the pig heart.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disopyramide; Electrocardiography; Flecainide; Lidocaine; Mexiletine; Models, Biological; Sodium-Potassium-Exchanging ATPase; Swine; Ventricular Fibrillation; Verapamil | 1996 |
Use of differential normal pulse voltammetry for the measurement of locus coeruleus catecholaminergic metabolism in an acute anaesthetized rodent model of allodynia: effect of mexiletine.
Topics: Anesthesia; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Catecholamines; Electrodes, Implanted; Electrophysiology; Glycine Agents; Lidocaine; Locus Coeruleus; Male; Mexiletine; Oxidation-Reduction; Pain; Rats; Rats, Sprague-Dawley; Strychnine | 1997 |
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle.
Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro Techniques; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Quinidine; Rats; Rats, Sprague-Dawley | 1997 |
Lidocaine and oral mexiletine block reflex bronchoconstriction in asthmatic subjects.
Topics: Administration, Oral; Aerosols; Anesthetics, Local; Asthma; Bronchoconstriction; Humans; Injections, Intravenous; Intubation, Intratracheal; Lidocaine; Mexiletine; Reflex | 1997 |
Class I antiarrhythmic drugs alter the severity of myocardial stunning by modulating ATP-sensitive K+ channels in guinea pig ventricular muscles.
Topics: Animals; Anti-Arrhythmia Agents; Glyburide; Guinea Pigs; Heart; Heart Ventricles; Imidazoles; Lidocaine; Male; Mexiletine; Myocardial Stunning; Potassium Channels | 1998 |
Effects of lidocaine and mexiletine on defibrillation energy requirements in animals treated with flecainide.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Electric Countershock; Flecainide; Lidocaine; Mexiletine; Ventricular Fibrillation | 1998 |
Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation.
Topics: Anesthetics, Local; Animals; Benzocaine; Electrophysiology; Female; Horse Diseases; Horses; Hyperkalemia; In Vitro Techniques; Lidocaine; Membrane Potentials; Mexiletine; Mutagenesis, Site-Directed; Oocytes; Paralyses, Familial Periodic; Point Mutation; Rats; Sodium Channels; Xenopus laevis | 1998 |
Mexiletine in the treatment of blepharospasm: experience with the first three patients.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Blepharospasm; Electromyography; Female; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged | 1999 |
Differential effects of lidocaine and mexiletine on relaxations to ATP-sensitive K+ channel openers in rat aortas.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Lidocaine; Male; Mexiletine; Potassium Channels; Rats; Rats, Inbred WKY; Vasodilation | 1999 |
Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide.
Topics: Anti-Arrhythmia Agents; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Immunoblotting; In Vitro Techniques; Kinetics; Lidocaine; Mexiletine; Models, Molecular; Oxidoreductases; Tocainide | 1999 |
[A successful treatment with intravenous lidocaine followed by oral mexiletine in a patient with Lennox-Gastaut syndrome].
Topics: Administration, Oral; Adolescent; Epilepsies, Myoclonic; Epilepsy, Absence; Epilepsy, Generalized; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Syndrome; Treatment Outcome | 1999 |
Lidocaine and mexiletine therapy for erythromelalgia.
Topics: Administration, Oral; Adult; Drug Therapy, Combination; Erythromelalgia; Follow-Up Studies; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Pain Measurement | 1999 |
[Effect of mexiletine on spontaneous sensory afferent activity in spontaneous diabetic rats (WBN/Kob rats)].
Topics: Action Potentials; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Disease Models, Animal; Lidocaine; Mexiletine; Nerve Fibers; Neurons, Afferent; Peripheral Nervous System Diseases; Rats; Rats, Inbred Strains; Rats, Wistar | 2000 |
Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na(+) currents in rat sensory neurons.
Topics: Amitriptyline; Analgesics; Anesthetics, Local; Animals; Cells, Cultured; Diethylcarbamazine; Drug Interactions; Electric Stimulation; Lidocaine; Memantine; Membrane Potentials; Mexiletine; Neurons, Afferent; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2001 |
Mild alkalinization and acidification differentially modify the effects of lidocaine or mexiletine on vasorelaxation mediated by ATP-sensitive K+ channels.
Topics: Acids; Alkalies; Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; ATP-Binding Cassette Transporters; Cromakalim; Endothelium, Vascular; Hydrogen-Ion Concentration; In Vitro Techniques; KATP Channels; Lidocaine; Mexiletine; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Vasodilator Agents | 2001 |
Lidocaine potentiates atrial natriuretic peptide-induced relaxation of bovine tracheal smooth muscle.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Natriuretic Factor; Cattle; Cyclic GMP; Drug Interactions; Drug Synergism; In Vitro Techniques; Lidocaine; Methacholine Chloride; Mexiletine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Donors; Nitro Compounds; Nitroprusside; Trachea | 2001 |
Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Calcium; Diazoxide; Heart Ventricles; Lidocaine; Male; Mexiletine; Mitochondria, Heart; Oxygen Consumption; Potassium Channels; Rats; Rats, Wistar | 2001 |
Mexiletine inhibits pharmacological actions of salbutamol through blockade of beta2-adrenoceptors in bovine tracheal smooth muscle.
Topics: Adrenergic beta-Antagonists; Albuterol; Animals; Anti-Arrhythmia Agents; Bronchodilator Agents; Cattle; Cyclic AMP; Lidocaine; Mexiletine; Muscle Relaxation; Muscle, Smooth; Trachea | 2001 |
[Lipomatosis dolorosa--a frequently overlooked disease picture].
Topics: Adiposis Dolorosa; Diagnosis, Differential; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Lidocaine; Mexiletine; Middle Aged | 2002 |
Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine.
Topics: Aged; Aged, 80 and over; Animals; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Drug Interactions; Humans; Least-Squares Analysis; Lidocaine; Male; Mexiletine; Rabbits; Tachycardia, Ventricular | 2002 |
A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.
Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Lamotrigine; Lidocaine; Male; Mexiletine; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Time Factors; Tocainide; Triazines | 2003 |
[Treatment of familial erythermalgia with the association of lidocaine and mexiletine].
Topics: Administration, Oral; Adolescent; Adult; Anesthetics, Local; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Erythromelalgia; Female; Humans; Injections, Intravenous; Lidocaine; Male; Mexiletine; Sodium Channel Blockers; Treatment Outcome | 2003 |
Nifekalant hydrochloride, a novel class III antiarrhythmic agent, suppressed postoperative recurrent ventricular tachycardia in a patient undergoing coronary artery bypass grafting and the Dor approach.
Topics: Aged; Anti-Arrhythmia Agents; Coronary Artery Bypass; Drug Resistance; Electric Countershock; Electrocardiography; Humans; Lidocaine; Male; Mexiletine; Potassium Channel Blockers; Pyrimidinones; Tachycardia, Ventricular | 2003 |
Stable expression and characterization of human PN1 and PN3 sodium channels.
Topics: Anesthetics, Local; Animals; Cell Line; Cloning, Molecular; DNA, Complementary; Electrophysiology; Humans; Lidocaine; Mexiletine; NAV1.7 Voltage-Gated Sodium Channel; NAV1.8 Voltage-Gated Sodium Channel; Neuropeptides; Rats; Sodium Channel Blockers; Sodium Channels; Transfection | 2003 |
Characterization of mexiletine as an antagonist of beta-adrenoceptor in Chinese hamster ovary cells expressing cloned human beta-adrenoceptors.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Binding, Competitive; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Drug Interactions; Female; Humans; Iodine Radioisotopes; Isoproterenol; Kinetics; Lidocaine; Mexiletine; Pindolol; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Transfection | 2004 |
Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.
Topics: Amino Acid Substitution; Anti-Arrhythmia Agents; Heart; Humans; Leucine; Lidocaine; Mexiletine; Mutation; Myocardium; Serine; Sodium Channel Blockers; Sodium Channels | 2004 |
Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Disease Models, Animal; Electrocardiography; Hemodynamics; KATP Channels; Lidocaine; Mexiletine; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rabbits; Sarcolemma; Sodium Channel Blockers; Stroke Volume; Ventricular Function, Left | 2004 |
A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.
Topics: Amino Acid Substitution; Amino Acids, Aromatic; Anesthetics, Local; Animals; Cysteine; Female; Lidocaine; Mexiletine; Mutagenesis, Site-Directed; Receptors, Drug; Sodium Channel Blockers; Sodium Channels; Tryptophan; Xenopus laevis | 2005 |
[The filter region of the myocardial Na channel, together with ion selectivity, controls pharmacodynamics of anti-arrhythmia agents--an analysis using the channel altered by idiopathic ventricular fibrillation].
Topics: Anti-Arrhythmia Agents; Filtration; Heart; Humans; In Vitro Techniques; Lidocaine; Mexiletine; Muscle Proteins; NAV1.5 Voltage-Gated Sodium Channel; Sodium Channels; Ventricular Fibrillation | 2004 |
Systemic lidocaine and mexiletine for the treatment of a patient with total ulcerative colitis.
Topics: Adult; Anesthetics, Local; Colitis, Ulcerative; Drug Therapy, Combination; Humans; Lidocaine; Male; Mexiletine | 2005 |
Inhibitory effects of lidocaine and mexiletine on vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels and the role of kinases in the porcine coronary artery.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Lidocaine; Membrane Potentials; Mexiletine; Potassium Channels; Protein Kinase C; Protein-Tyrosine Kinases; Swine; Vasodilation | 2005 |
Primary erythromelalgia in a child responding to intravenous lidocaine and oral mexiletine treatment.
Topics: Administration, Oral; Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Child; Erythromelalgia; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine | 2005 |
Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.
Topics: Ambroxol; Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Benzocaine; Drug Resistance; Lidocaine; Mexiletine; NAV1.2 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neurons, Afferent; Patch-Clamp Techniques; Rats; Recombinant Proteins; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2006 |
The cutaneous analgesic effect of class I antiarrhythmic drugs.
Topics: Analgesics; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Bupivacaine; Dose-Response Relationship, Drug; Flecainide; Injections, Subcutaneous; Lidocaine; Male; Mexiletine; Pain Measurement; Pain Threshold; Quinidine; Rats; Rats, Sprague-Dawley; Reflex; Skin; Sodium Channel Blockers; Time Factors | 2007 |
Mexiletine therapy for chronic pain: survival analysis identifies factors predicting clinical success.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Choice Behavior; Chronic Disease; Female; Humans; Kaplan-Meier Estimate; Lidocaine; Male; Mexiletine; Middle Aged; Neuralgia; Predictive Value of Tests; Retrospective Studies; Sodium Channel Blockers | 2008 |
Intravenous lidocaine infusion for the treatment of post-acoustic neuroma resection headache: a case report.
Topics: Analgesics, Opioid; Anesthetics, Local; Headache; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged; Neuroma, Acoustic; Neurosurgical Procedures; Otologic Surgical Procedures; Postoperative Complications | 2009 |
Mexiletine and lidocaine suppress the excitability of dorsal horn neurons.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Female; Lidocaine; Male; Mexiletine; Neural Inhibition; Posterior Horn Cells; Rats | 2009 |
Neonatal long QT syndrome type 3 predicted by positive lidocaine challenge.
Topics: Anti-Arrhythmia Agents; Bradycardia; Electrocardiography; Female; Humans; Infant, Newborn; Lidocaine; Long QT Syndrome; Mexiletine; Propranolol | 2010 |
Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain.
Topics: Adult; Aged; Axons; Electric Conductivity; Electrophysiological Phenomena; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Neuralgia; Pain Threshold; Paresthesia; Radial Nerve; Sensory Receptor Cells; Sodium Channels | 2010 |
Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.
Topics: Brain; Cell Line; Flecainide; Heart; Humans; Lidocaine; Mexiletine; Muscle Proteins; Muscle, Skeletal; NAV1.1 Voltage-Gated Sodium Channel; NAV1.4 Voltage-Gated Sodium Channel; NAV1.5 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Patch-Clamp Techniques; Sodium Channel Blockers; Sodium Channels | 2010 |
Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks.
Topics: Acetanilides; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cohort Studies; Defibrillators, Implantable; Drug Therapy, Combination; Electric Countershock; Electrocardiography; Female; Humans; Hypoglycemia; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Ischemia; Piperazines; Ranolazine; Sotalol; Stroke Volume; Tachycardia, Ventricular; Treatment Outcome | 2011 |
Primary erythromelalgia in a 12-year-old boy: positive response to sodium channel blockers despite negative SCN9A mutations.
Topics: Administration, Oral; Amines; Analgesics; Child; Cyclohexanecarboxylic Acids; Diagnosis, Differential; DNA Mutational Analysis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Erythromelalgia; Gabapentin; gamma-Aminobutyric Acid; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine; NAV1.7 Voltage-Gated Sodium Channel; Nitroprusside; Sodium Channel Blockers; Treatment Outcome; Vasodilator Agents | 2012 |
Oral mexiletine for lidocaine-responsive neonatal epilepsy.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Infusions, Intravenous; Lidocaine; Male; Mexiletine | 2013 |
Lidocaine and structure-related mexiletine induce similar contractility-enhancing effects in ischaemia-reperfusion injured equine intestinal smooth muscle in vitro.
Topics: Animals; Creatine Kinase; Horses; Intestines; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle, Smooth; Reperfusion Injury; Voltage-Gated Sodium Channel Blockers | 2013 |
Erythromelagia: a rare and hard-to-treat condition: a 9-year-old boy responsive to intravenous lidocaine and oral mexilitene.
Topics: Administration, Intravenous; Administration, Oral; Child; Erythromelalgia; Humans; Lidocaine; Male; Mexiletine; Voltage-Gated Sodium Channel Blockers | 2013 |
New index of pain triggered by spinal activation of voltage-dependent sodium channels.
Topics: Amitriptyline; Animals; gamma-Aminobutyric Acid; Injections, Spinal; Lidocaine; Male; Mexiletine; Mice; Mice, Inbred ICR; Morphine; Nociceptive Pain; Pain Management; Pain Measurement; Pregabalin; Spine; Voltage-Gated Sodium Channel Agonists; Voltage-Gated Sodium Channels | 2013 |
Effects of Na+ channel blockers on extrasystolic stimulation-evoked changes in ventricular conduction and repolarization.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiological Phenomena; Female; Flecainide; Guinea Pigs; Heart Ventricles; Lidocaine; Mexiletine; Quinidine; Sodium Channel Blockers; Tachycardia, Ventricular | 2014 |
Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.
Topics: Anti-Arrhythmia Agents; HEK293 Cells; Humans; Lidocaine; Membrane Potentials; Mexiletine; NAV1.5 Voltage-Gated Sodium Channel; NAV1.7 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Sodium Channel Blockers | 2015 |
Surfactant-assisted dispersive liquid-liquid microextraction combined with field-amplified sample stacking in capillary electrophoresis for the determination of mexiletine and lidocaine.
Topics: Electrophoresis, Capillary; Humans; Lidocaine; Limit of Detection; Liquid Phase Microextraction; Mexiletine; Surface-Active Agents | 2017 |
Case Report: Utility of Ketamine, Lidocaine, and Mexiletine as Nonopioid Adjuvants in Complex Cancer-Associated Pain.
Topics: Adult; Analgesics; Analgesics, Opioid; Anesthetics, Local; Cancer Pain; Carcinoma, Squamous Cell; Female; Humans; Ketamine; Lidocaine; Mexiletine; Pain, Intractable; Rectal Neoplasms | 2018 |
Ventricular Tachycardia Storm After Standard Radiofrequency Pulmonary Vein Isolation.
Topics: Aged; Anti-Arrhythmia Agents; Cicatrix; Electric Countershock; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Pulmonary Veins; Radiofrequency Ablation; Tachycardia, Ventricular; Treatment Outcome | 2019 |
A Multi-Centered Case Series Highlighting the Clinical Use and Dosing of Lidocaine and Mexiletine for Refractory Cancer Pain.
Topics: Administration, Oral; Adult; Aged; Anesthetics, Local; Cancer Pain; Female; Humans; Infusions, Intravenous; Lidocaine; Male; Mexiletine; Middle Aged; Pain, Intractable; Retrospective Studies | 2020 |
Inhibition of cardiac K
Topics: Animals; Anti-Arrhythmia Agents; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Oocytes; Potassium Channel Blockers; Protein Isoforms; Shal Potassium Channels; Xenopus laevis | 2020 |
[Paroxysmal vascular acrosyndromes: Practical approach to diagnosis and management].
Topics: Antibodies, Antinuclear; Aspirin; Calcium Channel Blockers; Erythromelalgia; Gabapentin; Humans; Iloprost; Lidocaine; Mexiletine; Raynaud Disease; Small Fiber Neuropathy; Sodium Channel Blockers | 2022 |
Protein 14-3-3 Influences the Response of the Cardiac Sodium Channel Na
Topics: 14-3-3 Proteins; Anti-Arrhythmia Agents; HEK293 Cells; Humans; Lidocaine; Mexiletine; Quinidine; Sodium Channels | 2023 |
Functional characterization and identification of a therapeutic for a novel SCN5A-F1760C variant causing type 3 long QT syndrome refractory to all guideline-directed therapies.
Topics: Anti-Arrhythmia Agents; Humans; Infant; Lidocaine; Long QT Syndrome; Mexiletine; NAV1.5 Voltage-Gated Sodium Channel | 2023 |