lidocaine has been researched along with haloperidol in 50 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 13 (26.00) | 18.7374 |
1990's | 4 (8.00) | 18.2507 |
2000's | 16 (32.00) | 29.6817 |
2010's | 15 (30.00) | 24.3611 |
2020's | 2 (4.00) | 2.80 |
Authors | Studies |
---|---|
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
Topliss, JG; Yoshida, F | 1 |
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
Caron, G; Ermondi, G | 1 |
Abraham, MH; Acree, WE; Ibrahim, A | 1 |
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Ahman, M; Holmén, AG; Wan, H | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Glen, RC; Lowe, R; Mitchell, JB | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Sen, S; Sinha, N | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Bellman, K; Knegtel, RM; Settimo, L | 1 |
Brouillette, WJ; Brown, GB; Zha, C | 1 |
Artursson, P; Mateus, A; Matsson, P | 1 |
Bennis, K; Ducki, S; Lesage, F; Vivier, D | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
Chłoń-Rzepa, G; Dąbrowska, M; Jankowska, A; Komsta, Ł; Pawłowski, M; Ślusarczyk, M; Starek, M; Zagórska, A | 1 |
Albert, DJ; Richmond, SE | 1 |
Friedman, SJ; Skehan, P | 1 |
Pierson, C; Quadri, SK; Spies, HG | 1 |
Akaoka, H; Buda, M; Charléty, P; Chouvet, G; Saunier, CF | 1 |
Ahlemeyer, B; Krieglstein, J | 1 |
Kim, HK; Sato, T; Suzuki, TA; Yoneyama, T | 1 |
Dill, PL; Duarte, TE; Nagourney, RA; Su, YZ; Weisenthal, LM | 1 |
Russell, RD; Stripling, JS | 1 |
Benediktov, II; Blinov, PS | 1 |
Ueda, I; Wada, T | 1 |
Kadzielawa, K | 1 |
Williams, JE | 1 |
Calesnick, B; Capetola, R; Ferko, AP | 1 |
Finley, RR; Leeds, AL | 1 |
Bittencourt, AL; Takahashi, RN | 1 |
Bardgett, ME; Henry, JD | 1 |
Itthagarun, A; Tay, FR | 1 |
Ellis, LD; Soanes, KH | 1 |
Ba-M'hamed, S; Bennis, M; Ouhaz, Z | 1 |
Baastrup, C; Benedetti, F; Grosen, K; Hall, KT; Jensen, TS; Kaptchuk, TJ; Moslemi, K; Petersen, GL; Price, DD; Skyt, I; Svensson, P; Vase, L | 1 |
Li, H; Li, P; Li, S; Wang, R | 1 |
3 review(s) available for lidocaine and haloperidol
Article | Year |
---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pain; Potassium Channels, Tandem Pore Domain; Structure-Activity Relationship | 2016 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Different interventions for preventing postoperative catheter-related bladder discomfort: a systematic review and meta-analysis.
Topics: Chlorpheniramine; Dexmedetomidine; Gabapentin; Haloperidol; Humans; Ketamine; Lidocaine; Meperidine; Nefopam; Pain, Postoperative; Pregabalin; Tolterodine Tartrate; Tramadol; Urinary Bladder; Urinary Catheters | 2022 |
47 other study(ies) available for lidocaine and haloperidol
Article | Year |
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[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity.
Topics: Analgesics; Benzeneacetamides; Cyclic Nucleotide Phosphodiesterases, Type 7; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Phenylbutyrates; Phosphodiesterase 4 Inhibitors; Principal Component Analysis; Quantitative Structure-Activity Relationship; TRPA1 Cation Channel; Xanthines | 2021 |
Reactivity and aggression in the rat: induction by alpha-adrenergic blocking agents injected ventral to anterior septum but not into lateral septum.
Topics: Adrenergic alpha-Antagonists; Aggression; Anesthesia, Local; Animals; Atropine; Haloperidol; Humans; Hydralazine; Lidocaine; Male; Phentolamine; Propranolol; Rats; Receptors, Adrenergic, alpha; Reflex, Startle; Scopolamine; Septum Pellucidum; Tolazoline; Vocalization, Animal | 1977 |
The inhibition of sterol synthesis by anesthetics.
Topics: Acetates; Anesthetics, Local; Animals; Cell Line; Chlorpromazine; Diphenylacetic Acids; Glioma; Haloperidol; Ketamine; Lidocaine; Lipids; Pentobarbital; Rats; Sterols; Tetracaine | 1979 |
Effects of centrally acting drugs on serum prolactin levels in rhesus monkeys.
Topics: Anesthetics; Animals; Estradiol; Female; Haloperidol; Halothane; Haplorhini; Immobilization; Ketamine; Lidocaine; Macaca mulatta; Pentobarbital; Phenoxybenzamine; Phentolamine; Prolactin; Propranolol; Sympatholytics | 1978 |
Inhibition of nigral dopamine neurons by systemic and local apomorphine: possible contribution of dendritic autoreceptors.
Topics: Animals; Apomorphine; Benzazepines; Bicuculline; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Ergolines; Evoked Potentials; gamma-Aminobutyric Acid; Haloperidol; Injections, Intravenous; Lidocaine; Male; Microinjections; Neurons; Phenethylamines; Quinpirole; Rats; Rats, Wistar; Substantia Nigra | 1992 |
Testing drug effects against hypoxic damage of cultured neurons during long-term recovery.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Brain Ischemia; Cell Count; Cell Survival; Cells, Cultured; Chick Embryo; Clonazepam; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Flunarizine; Haloperidol; Imipramine; Ketamine; Lidocaine; Nafronyl; Neurons; Pyrithioxin; Telencephalon | 1989 |
Effect of dopamine and haloperidol on the c-wave and light peak of light-induced retinal responses in chick eye.
Topics: Animals; Chickens; Dopamine; Dose-Response Relationship, Drug; Electroretinography; Haloperidol; Injections; Lidocaine; Retina; Synaptic Transmission; Vitreous Body | 1987 |
Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C.
Topics: Cell Survival; Chlorpromazine; Drug Resistance; Drug Synergism; Haloperidol; Humans; Imipramine; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Lidocaine; Protein Kinase C; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1987 |
Monoaminergic and local anesthetic components of cocaine's effects on kindled seizure expression.
Topics: Amphetamine; Anesthetics, Local; Animals; Biogenic Amines; Cocaine; Drug Interactions; Haloperidol; Kindling, Neurologic; Lidocaine; Male; Metergoline; Prazosin; Propranolol; Rats; Seizures; Yohimbine | 1985 |
[Methods of anesthesia in obstetric surgery].
Topics: Anesthesia, Obstetrical; Anesthetics; Anesthetics, Local; Antipsychotic Agents; Atropine; Diphenhydramine; Droperidol; Female; Haloperidol; Halothane; Histamine H1 Antagonists; Humans; Ketamine; Lidocaine; Methoxyflurane; Parasympatholytics; Pregnancy; Pregnanediones; Promethazine; Trichloroethylene | 1974 |
Determination of inorganic phosphate by the molybdovanadate method in the presence of ATP and some interfering organic bases.
Topics: Adenosine Triphosphate; Alcohols; Anesthetics, Local; Chlorpromazine; Diazepam; Haloperidol; Hydroxyzine; Lidocaine; Methods; Molybdenum; Perphenazine; Phenothiazines; Phosphates; Procaine; Prochlorperazine; Spectrophotometry; Tranquilizing Agents; Trichloroacetic Acid; Vanadium | 1970 |
The EEG effects of dopa in the rabbit depending upon the level of brain-stem section.
Topics: Animals; Brain Stem; Cerebral Cortex; Cerebral Decortication; Chlorpromazine; Decerebrate State; Dihydroxyphenylalanine; Electrocardiography; Electrodes, Implanted; Electroencephalography; Gallamine Triethiodide; Haloperidol; Imipramine; Injections, Intra-Arterial; Lidocaine; Limbic System; Phenoxybenzamine; Rabbits; Stereotaxic Techniques | 1974 |
Microlaryngoscopy under neurolept analgesia.
Topics: Aged; Anesthesia, Local; Female; Haloperidol; Humans; Laryngoscopy; Lidocaine; Male; Methods; Neuroleptanalgesia; Phenoperidine | 1972 |
The inhibitory action of dopamine on the rat anterior tibialis muscle preparation.
Topics: Animals; Anura; Chlorpromazine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Edrophonium; Electric Stimulation; Haloperidol; In Vitro Techniques; Injections, Intra-Arterial; Injections, Intravenous; Lidocaine; Male; Muscle Contraction; Muscles; Neural Conduction; Paralysis; Rats; Sciatic Nerve; Time Factors; Tubocurarine | 1974 |
Improving drug therapy in the elderly.
Topics: Aged; Benzodiazepines; Drug Therapy; Female; Haloperidol; Histamine H1 Antagonists; Humans; Lidocaine; Male | 1993 |
Mazindol and lidocaine are antinociceptives in the mouse formalin model: involvement of dopamine receptor.
Topics: Anesthetics, Local; Animals; Benzazepines; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Haloperidol; Lidocaine; Male; Mazindol; Mice; Naloxone; Narcotic Antagonists; Nociceptors; Pain Measurement; Receptors, Dopamine; Receptors, Opioid | 1997 |
Locomotor activity and accumbens Fos expression driven by ventral hippocampal stimulation require D1 and D2 receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Benzazepines; Brain Chemistry; Cycloleucine; Dextroamphetamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Agonists; Genes, Immediate-Early; Glutamic Acid; Haloperidol; Hippocampus; Kainic Acid; Lidocaine; Locomotion; Male; N-Methylaspartate; Neural Pathways; Neuroprotective Agents; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1999 |
Self-contamination of deep dentin by dentin fluid.
Topics: Acid Etching, Dental; Adult; Anesthetics, Local; Dental Caries; Dental Cavity Preparation; Dental Impression Materials; Dentin; Dentinal Fluid; Epinephrine; Epoxy Resins; Humans; Lidocaine; Mepivacaine; Microscopy, Electron; Microscopy, Electron, Scanning; Odontoblasts; Phosphoric Acids; Polyvinyls; Replica Techniques; Siloxanes; Smear Layer; Vasoconstrictor Agents | 2000 |
A larval zebrafish model of bipolar disorder as a screening platform for neuro-therapeutics.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Bipolar Disorder; Dark Adaptation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; GABA Antagonists; Haloperidol; Larva; Lidocaine; Pentylenetetrazole; Seizures; Video Recording; Zebrafish | 2012 |
Haloperidol treatment at pre-exposure phase reduces the disturbance of latent inhibition in rats with neonatal ventral hippocampus lesions.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Haloperidol; Hippocampus; Lidocaine; Motor Activity; Rats; Rats, Sprague-Dawley; Schizophrenia; Schizotypal Personality Disorder; Taste | 2014 |
Dopaminergic tone does not influence pain levels during placebo interventions in patients with chronic neuropathic pain.
Topics: Adult; Aged; Anesthetics, Local; Carbidopa; Chronic Pain; Dopamine; Dopamine Agents; Drug Combinations; Female; Haloperidol; Humans; Levodopa; Lidocaine; Male; Middle Aged; Motivation; Neuralgia; Placebo Effect; Placebos; Psychological Tests; Retrospective Studies; Suggestion | 2018 |