lidocaine has been researched along with diphenhydramine in 87 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (26.44) | 18.7374 |
| 1990's | 17 (19.54) | 18.2507 |
| 2000's | 24 (27.59) | 29.6817 |
| 2010's | 17 (19.54) | 24.3611 |
| 2020's | 6 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Hashimoto, N; Nezu Ji, J; Nikaido, H; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Caron, G; Ermondi, G | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Freund, M; Peterson, RN | 1 |
| Papadimituiou, JM; Sforcina, D | 1 |
| Verrill, PJ | 1 |
| Johnson, HL; Maibach, HI | 1 |
| Asakura, K; Kataura, A; Kojima, T; Narita, S; Shirasaki, H | 1 |
| Izumi, H; Karita, K | 1 |
| Barnes, M; Blakeslee, DB; Carnel, SB; Oswald, SG | 1 |
| Weiss, M | 1 |
| Katona, PG; Rigel, DF | 1 |
| Ellis, E; Gallo, WJ | 1 |
| Altura, BM; Altura, BT | 1 |
| Benediktov, II; Blinov, PS | 1 |
| Altura, BM; Zweifach, BW | 1 |
| Gault, FP; Yules, RB | 1 |
| Kośmider, S; Smolarz, W | 1 |
| Büchi, J; Koller, RJ; Perlia, X | 1 |
| Dowdy, EG; Yamanaka, I | 1 |
| Bass, KD | 1 |
| Magazanik, LG | 1 |
| Munsey, WF | 1 |
| Kopp, WL | 1 |
| Karmen, A; Keren, G; Knapp, AB; Levitt, B; Maguire, W; Miura, DS; Somberg, JC | 1 |
| Gorchynski, J; Green, SM; Rothrock, SG | 1 |
| Ernst, AA; Mall, G; Marvez-Valls, E; Patterson, J; Weiss, SJ; Xie, X | 1 |
| Dire, DJ; Hogan, DE | 1 |
| McDonnell, KP; Winn, RE | 1 |
| Baroody, FM; Naclerio, RM; Wagenmann, M | 1 |
| Anand, P; Ernst, AA; Nick, T; Wassmuth, S | 1 |
| Green, SM | 1 |
| Ernst, AA; Marvez-Valls, E; Nick, TG; Wahle, M | 1 |
| Aitken-Nichol, C; McGinity, JW; Zhang, F | 1 |
| Kim, R; Lee, J; Meredith, R; Rodu, B; Salter, M; Smith, J; Spencer, S; Weppelmann, B | 1 |
| Baroni, C; Bondi, E; Carrassi, A; Gatti, M; Lodi, G; Porter, SR; Prete, A | 1 |
| Muszynski, MJ; Rajyaguru, JM | 1 |
| Bartfield, JM; Jandreau, SW; Raccio-Robak, N | 1 |
| Huang, RC; Kuo, CC; Lou, BS | 1 |
| Gerayli, A; Leung, AY; Ridgeway, BM; Wallace, MS; Yaksh, TL | 1 |
| Erdal, S; Karacay, S; Turhal, NS | 1 |
| Pragst, F; Sporkert, F | 1 |
| Dibble, SL; Dodd, MJ; Greenspan, D; Larson, P; MacPhail, L; Miaskowski, C; Paul, SM; Shiba, G | 1 |
| Arase, S; Miyaoka, Y; Skrebova, N; Takiwaki, H | 1 |
| Chen, E; McSweeney, TD; Reilley, TE; Tibbits, DL; Xia, Y | 1 |
| JAKUBOWSKI, W; MEYER, RA | 1 |
| CAMPOLATTARO, JP; HAROLDSON, JH | 1 |
| KANE, JP; WELBORN, JF | 1 |
| DEJONG, RH | 1 |
| Simon, HB | 1 |
| Chan, A; Ignoffo, RJ | 1 |
| Faden, H | 1 |
| Apiliogullari, B; Apiliogullari, S; Balasar, M; Duman, A; Keles, B; Yilmaz, H | 1 |
| Beck, M; Drum, M; Nusstein, J; Reader, A; Willett, J | 1 |
| Chen, YC; Chen, YW; Chu, CC; Hung, CH; Li, ZY; Wang, JJ | 1 |
| Montagnese, TA; Setty, M | 1 |
| Adamo, A; Behnam, M; Beingessner, RL; Chen, J; Jamison, TF; Jensen, KF; Monbaliu, JC; Myerson, AS; Revalor, EM; Snead, DR; Stelzer, T; Weeranoppanant, N; Wong, SY; Zhang, P | 1 |
| Brown, SD; Huffman, J; Kirk, LM; Lewis, PO; Luu, Y; Ogle, A | 1 |
| Adhikari, S; Alexander, K; Boddu, SHS; Daftardar, S; Fratev, F; Rivera, M; Sirimulla, S | 1 |
| Alvarez, K; Bina, B; Hersh, EV; Hilario, M; McLaughlin, B | 1 |
| Elad, S; Yarom, N | 1 |
| Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD | 1 |
| Morley-Forster, PK; Moulin, DE; Pirani, Z; Rohfritsch, C; Stitt, L | 1 |
| Hershey, AD; Kabbouche, M; Maconochie, I; Murphy, B; Qaiser, S; Werner, K | 1 |
| Anghelache, M; Ascenzi, P; Bucatariu, SM; Calin, M; Carnuta, M; Constantin, M; Fundueanu, G; Nicolescu, A; Prisacaru, I; Rusu, D; Varganici, CD | 1 |
| Ahn, DK; Ju, JS; Kim, MS; Lim, JS; Oh, JS; Park, JH; Son, JY; Yoon, HW | 1 |
| Algarra, M; Bjelaković, MS; Dučić, T; Gojgić Cvijović, GD; Kop, TJ; Korićanac, L; Liang, X; Mi, L; Mitrović, A; Nešić, MD; Petković, M; Stepić, M; Žakula, J | 1 |
| Browne, T; Cervantes, A; Logan, BK; Nelson, BN; Strathmann, FG | 1 |
| Iwata, YT; Kanamori, T; Kuwayama, K; Miyaguchi, H; Okada, Y; Segawa, H; Tsujikawa, K; Yamamuro, T | 1 |
6 review(s) available for lidocaine and diphenhydramine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Effects of local anesthetics, antihistamines, and glucocorticoids on peripheral blood flow and vascular smooth muscle.
Topics: Anesthetics, Local; Animals; Blood Vessels; Cats; Diphenhydramine; Dogs; Glucocorticoids; Histamine; Histamine H1 Antagonists; Humans; Hydrocortisone; In Vitro Techniques; Inflammation; Lidocaine; Mepivacaine; Microcirculation; Muscle, Smooth; Procaine; Promethazine; Rabbits; Rats; Regional Blood Flow; Shock, Hemorrhagic; Tetracaine | 1974 |
What is the role of diphenhydramine in local anesthesia?
Topics: Anesthesia, Local; Anesthetics, Local; Diphenhydramine; Drug Hypersensitivity; Emergency Medical Services; Humans; Lidocaine; Wounds and Injuries | 1996 |
Management of primary herpetic gingivostomatitis in young children.
Topics: Acyclovir; Administration, Oral; Aluminum Hydroxide; Analgesics; Anesthetics, Local; Antacids; Antiviral Agents; Child; Child, Preschool; Diphenhydramine; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Fluid Therapy; Humans; Incidence; Infant; Lidocaine; Magnesium Hydroxide; Male; New York; Stomatitis, Herpetic | 2006 |
True Allergy to Amide Local Anesthetics: A Review and Case Presentation.
Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Contraindications, Drug; Diphenhydramine; Drug Hypersensitivity; Facial Pain; Female; Humans; Lidocaine; Oral Surgical Procedures; Pain Measurement; Pain, Postoperative; Treatment Outcome | 2018 |
Intravenous Migraine Treatment in Children and Adolescents.
Topics: Administration, Intravenous; Adolescent; Akathisia, Drug-Induced; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Basal Ganglia Diseases; Child; Dexamethasone; Dihydroergotamine; Diphenhydramine; Dopamine Antagonists; Emergency Service, Hospital; Enzyme Inhibitors; Fluid Therapy; Glucocorticoids; Hospitalization; Humans; Hypnotics and Sedatives; Ketorolac; Lidocaine; Magnesium; Migraine Disorders; Prochlorperazine; Propofol; Valproic Acid; Vasoconstrictor Agents | 2020 |
18 trial(s) available for lidocaine and diphenhydramine
| Article | Year |
|---|---|
Treatment of radiation- and chemotherapy-induced stomatitis.
Topics: Administration, Topical; Cocaine; Diphenhydramine; Drug Combinations; Humans; Kaolin; Lidocaine; Mouth Mucosa; Pectins; Propiophenones; Stomatitis; Tongue | 1990 |
Efficacy of diphenhydramine hydrochloride for local anesthesia before oral surgery.
Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Diphenhydramine; Double-Blind Method; Female; Humans; Lidocaine; Male; Preanesthetic Medication; Tooth Extraction | 1987 |
Validation of diphenhydramine as a dermal local anesthetic.
Topics: Adult; Anesthesia, Local; Diphenhydramine; Double-Blind Method; Female; Humans; Injections, Intradermal; Lidocaine; Male; Pain; Pain Measurement; Prospective Studies; Time Factors | 1994 |
1% lidocaine versus 0.5% diphenhydramine for local anesthesia in minor laceration repair.
Topics: Adult; Anesthesia, Local; Diphenhydramine; Double-Blind Method; Emergency Service, Hospital; Female; Humans; Injections, Intradermal; Injury Severity Score; Lidocaine; Linear Models; Male; Multivariate Analysis; Pain; Pain Measurement; Prospective Studies; Suture Techniques; Wounds, Penetrating | 1994 |
Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic.
Topics: Adult; Anesthetics, Local; Diphenhydramine; Double-Blind Method; Drug Hypersensitivity; Humans; Injections, Subcutaneous; Lidocaine; Male; Necrosis; Pain; Pain Measurement; Prospective Studies; Skin Diseases; Time Factors | 1993 |
Lidocaine versus diphenhydramine for anesthesia in the repair of minor lacerations.
Topics: Adolescent; Adult; Anesthetics, Local; Diphenhydramine; Evaluation Studies as Topic; Female; Humans; Injections; Lidocaine; Male; Middle Aged; Prospective Studies; Skin; Suture Techniques; Sutures | 1993 |
Comparison trial of four injectable anesthetics for laceration repair.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Diphenhydramine; Double-Blind Method; Drug Therapy, Combination; Epinephrine; Female; Humans; Injections, Intradermal; Lidocaine; Male; Pain Measurement; Prospective Studies; Sutures; Treatment Outcome; Wound Healing; Wounds and Injuries | 1996 |
Sucralfate for radiation mucositis: results of a double-blind randomized trial.
Topics: Anti-Ulcer Agents; Diphenhydramine; Double-Blind Method; Drug Therapy, Combination; Esophageal Neoplasms; Esophagus; Head and Neck Neoplasms; Humans; Lidocaine; Mucous Membrane; Radiation Injuries; Sucralfate | 1997 |
Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation.
Topics: Adolescent; Aluminum Hydroxide; Amphotericin B; Antineoplastic Agents; Bone Marrow Transplantation; Child; Child, Preschool; Colistin; Diphenhydramine; Drug Combinations; Drug Therapy, Combination; Humans; Infant; Lidocaine; Magnesium Hydroxide; Mouth Mucosa; Stomatitis; Tobramycin; Transplantation Conditioning | 1997 |
Randomized trial of diphenhydramine versus benzyl alcohol with epinephrine as an alternative to lidocaine local anesthesia.
Topics: Adult; Anesthetics, Local; Benzyl Alcohol; Diphenhydramine; Double-Blind Method; Drug Combinations; Drug Hypersensitivity; Epinephrine; Female; Humans; Injections, Subcutaneous; Lidocaine; Male; Middle Aged; Pain; Pain Measurement; Prospective Studies; Statistics, Nonparametric; Survival Analysis; Time Factors; Vasoconstrictor Agents | 1998 |
Concentration-effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and II.
Topics: Adult; Aged; Anesthetics, Local; Blood Pressure; Cold Temperature; Complex Regional Pain Syndromes; Diphenhydramine; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Pain; Pain Measurement | 2000 |
Efficacy of treatment to relieve mucositis-induced discomfort.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Antineoplastic Agents; Diphenhydramine; Female; Humans; Lidocaine; Male; Middle Aged; Mouthwashes; Neoplasms; Palliative Care; Severity of Illness Index; Sodium Bicarbonate; Sodium Chloride; Stomatitis | 2000 |
Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis.
Topics: Aluminum Hydroxide; Analysis of Variance; Anesthetics, Local; Antacids; Anti-Infective Agents, Local; Antineoplastic Agents; Chi-Square Distribution; Chlorhexidine; Diphenhydramine; Drug Combinations; Female; Humans; Lidocaine; Magnesium Hydroxide; Male; Middle Aged; Mouth Mucosa; Mouthwashes; Outcome Assessment, Health Care; Proportional Hazards Models; Sodium Bicarbonate; Sodium Chloride; Stomatitis; Survival Analysis | 2000 |
Comparison of effects of lidocaine hydrochloride, buffered lidocaine, diphenhydramine, and normal saline after intradermal injection.
Topics: Adult; Analysis of Variance; Anesthetics, Local; Diphenhydramine; Double-Blind Method; Female; Hand; Humans; Hypesthesia; Injections, Intradermal; Lidocaine; Male; Pain; Pain Measurement; Sodium Chloride; Time Factors | 2002 |
Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Diphenhydramine; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Injections, Intravenous; Lidocaine; Male; Pain; Pain Measurement; Propofol; Sodium Chloride; Treatment Outcome | 2007 |
The anesthetic efficacy of diphenhydramine and the combination diphenhydramine/lidocaine for the inferior alveolar nerve block.
Topics: Adult; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Local; Bicuspid; Cross-Over Studies; Dental Pulp; Dental Pulp Test; Diphenhydramine; Epinephrine; Female; Humans; Incisor; Injections; Lidocaine; Lip; Male; Mandibular Nerve; Molar; Nerve Block; Pain; Prospective Studies; Time Factors; Treatment Outcome; Vasoconstrictor Agents; Young Adult | 2008 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Method; Doxepin; Fatigue; Female; Head and Neck Neoplasms; Humans; Lidocaine; Linear Models; Male; Middle Aged; Mouthwashes; Pain; Radiation Injuries; Stomatitis | 2019 |
Intravenous lidocaine in the management of chronic peripheral neuropathic pain: a randomized-controlled trial.
Topics: Aged; Anesthetics, Local; Chronic Pain; Cross-Over Studies; Diabetic Neuropathies; Diphenhydramine; Double-Blind Method; Female; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Neuralgia, Postherpetic; Pain Measurement; Peripheral Nervous System Diseases; Quality of Life | 2019 |
63 other study(ies) available for lidocaine and diphenhydramine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carnitine; Carrier Proteins; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Humans; Male; Membrane Proteins; Mice; Mice, Inbred C3H; Organic Cation Transport Proteins; Solute Carrier Family 22 Member 5; Tetraethylammonium; Tissue Distribution; Tritium | 2001 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Identification and prediction of promiscuous aggregating inhibitors among known drugs.
Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Species independence in brain tissue binding using brain homogenates.
Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity | 2011 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
The inhibition of the motility of human spermatozoa by various pharmacologic agents.
Topics: Adenosine Monophosphate; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Chlorpromazine; Depression, Chemical; Diphenhydramine; Histamine H1 Antagonists; Humans; Lidocaine; Male; Parasympatholytics; Sperm Motility; Structure-Activity Relationship | 1975 |
The effects of drugs on monocytic fusion in vivo.
Topics: Adenosine Triphosphatases; Animals; Calcium; Cell Fusion; Cell Membrane; Cortisone; Cyclic AMP; Diphenhydramine; Edetic Acid; Glucagon; Insulin; Isoproterenol; Lidocaine; Lysosomes; Male; Mice; Mice, Inbred C57BL; Monocytes; Ouabain; Pyrilamine; Tetracaine; Trifluoperazine; Verapamil | 1975 |
Adverse reactions to local anaesthetics and vasoconstrictor drugs.
Topics: Anaphylaxis; Anesthesia, Dental; Anesthetics, Local; Arteriosclerosis; Blood Pressure; Coronary Disease; Diazepam; Diphenhydramine; Drug Hypersensitivity; Drug Interactions; Epinephrine; Heart Rate; Humans; Hydrocortisone; Hyperthyroidism; Lidocaine; Nitroglycerin; Norepinephrine; Pulse; Seizures; Stress, Psychological; Syncope; Vasoconstrictor Agents | 1975 |
Contact urticaria syndrome. Contact urticaria to diethyltoluamide (immediate-type hypersensitivity).
Topics: Adult; Ammonium Sulfate; Atropine; Benzamides; Benzocaine; Chlorpheniramine; DEET; Dermatitis, Contact; Diphenhydramine; Female; Histamine; Humans; Hypersensitivity, Immediate; Insect Repellents; Lidocaine; p-Methoxy-N-methylphenethylamine; Patch Tests; Urticaria | 1975 |
Study on the dye leakage response of nasal mucosa following topical, capsaicin challenge in guinea pigs.
Topics: Administration, Intranasal; Administration, Topical; Animals; Atropine; Benzenesulfonates; Capsaicin; Chromones; Coloring Agents; Diphenhydramine; Exudates and Transudates; Guinea Pigs; Histamine; Histamine Release; Injections, Subcutaneous; Lidocaine; Male; Methacholine Chloride; Nasal Mucosa; Nasal Provocation Tests; Substance P | 1992 |
Axon reflex flare evoked by nicotine in human skin.
Topics: Adult; Axons; Capsaicin; Diphenhydramine; Female; Humans; Injections, Intradermal; Lidocaine; Male; Middle Aged; Nerve Fibers; Nicotine; Receptors, Histamine; Reflex; Regional Blood Flow; Skin; Vasodilation | 1992 |
Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction.
Topics: Absorption; Antipyrine; Biological Availability; Caffeine; Diphenhydramine; Dose-Response Relationship, Drug; Humans; Ketanserin; Lidocaine; Liver Diseases; Metronidazole; Nomifensine; Triamterene | 1990 |
Effects of antihistamines and local anesthetics on excess tachycardia in conscious dogs.
Topics: Anesthetics, Local; Animals; Atropine; Chlorpheniramine; Diphenhydramine; Dogs; Dose-Response Relationship, Drug; Histamine; Histamine H1 Antagonists; Lidocaine; Male; Procaine; Promethazine; Pyrilamine; Tachycardia | 1986 |
[Methods of anesthesia in obstetric surgery].
Topics: Anesthesia, Obstetrical; Anesthetics; Anesthetics, Local; Antipsychotic Agents; Atropine; Diphenhydramine; Droperidol; Female; Haloperidol; Halothane; Histamine H1 Antagonists; Humans; Ketamine; Lidocaine; Methoxyflurane; Parasympatholytics; Pregnancy; Pregnanediones; Promethazine; Trichloroethylene | 1974 |
Pharmacologic properties of antihistamines in relation to vascular reactivity.
Topics: Adrenalectomy; Animals; Atropine; Blood Circulation; Blood Vessels; Chlorpheniramine; Chlorpromazine; Diphenhydramine; Histamine; Histamine H1 Antagonists; Isoproterenol; Lidocaine; Mesentery; Phenoxybenzamine; Phentolamine; Promethazine; Rats; Serotonin; Vasomotor System; Yohimbine | 1965 |
Effect of drugs on after-nystagmus induced by lateral vestibular nucleus stimulation.
Topics: Animals; Cats; Chlorpromazine; Cyclizine; Dimenhydrinate; Diphenhydramine; Electric Stimulation; Hydroxyzine; Lidocaine; Meclizine; Nystagmus, Pathologic; Pentobarbital; Phenothiazines; Piperazines; Prochlorperazine; Promethazine; Tripelennamine; Vestibular Nuclei | 1967 |
[Antiarrhythmic effect of sviomarin in experimental and clinical glycoside poisoning].
Topics: Animals; Arrhythmias, Cardiac; Digitalis Glycosides; Diphenhydramine; Dogs; Electrocardiography; Female; Heart Failure; Histamine H1 Antagonists; Humans; Injections, Intramuscular; Injections, Intravenous; Lidocaine; Male; Ouabain; Theophylline | 1969 |
[Relationship between chemical structure, physio-chemical properties, chemical reactivity and effect of various local anesthetics with position isomerism. 31. 1].
Topics: Acetanilides; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Local; Animals; Anthelmintics; Benzocaine; Binding Sites; Blood Pressure; Chemical Phenomena; Chemistry; Cocaine; Diphenhydramine; Ethylamines; Hydroxides; Isomerism; Lethal Dose 50; Lidocaine; Mice; Procaine; Propylamines; Quaternary Ammonium Compounds; Rabbits; Rats; Structure-Activity Relationship; Sulfanilamides | 1974 |
The effects of ketamine on spiral-cut strips of rabbit aorta.
Topics: Animals; Aorta; Diphenhydramine; Dose-Response Relationship, Drug; Histamine; Isoproterenol; Ketamine; Lidocaine; Muscle Contraction; Muscle, Smooth; Phentolamine; Phenylephrine; Procaine; Propranolol; Quinidine; Rabbits | 1974 |
Tissue response to diphenhydramine hydrochloride.
Topics: Animals; Anterior Chamber; Connective Tissue; Diphenhydramine; Injections, Subcutaneous; Lidocaine; Procaine; Rabbits; Sodium Chloride | 1970 |
[Effect of some membrane stabilizers on the function of the neuromuscular synapse].
Topics: Acetylcholine; Alcohols; Amobarbital; Animals; Anura; Chlorpromazine; Diphenhydramine; In Vitro Techniques; Lidocaine; Membranes; Neuromuscular Junction; Pentobarbital; Procaine; Promethazine; Rana temporaria | 1971 |
Diphenhydramine for local anesthesia in "caine" sensitive patients. A case report.
Topics: Adult; Anesthesia, Local; Diphenhydramine; Drug Hypersensitivity; Female; Humans; Lidocaine; Warts | 1966 |
Anaphylaxis from alphazurine 2G during lymphography.
Topics: Adult; Coloring Agents; Diphenhydramine; Drug Hypersensitivity; Epinephrine; Hodgkin Disease; Humans; Hydrocortisone; Injections, Intradermal; Injections, Intravenous; Lidocaine; Lymphography; Male; Middle Aged; Phimosis; Skin Tests; Urticaria | 1966 |
The cimetidine-lidocaine interaction.
Topics: Cimetidine; Diphenhydramine; Drug Interactions; Female; Guanidines; Humans; Lidocaine; Male; Middle Aged | 1983 |
Fatality secondary to massive overdose of dimenhydrinate.
Topics: Adult; Arrhythmias, Cardiac; Cardiopulmonary Resuscitation; Charcoal; Colon; Dimenhydrinate; Diphenhydramine; Dopamine; Drug Overdose; Female; Humans; Infarction; Lidocaine; Lorazepam; Nonprescription Drugs; Phenytoin; Status Epilepticus; Suicide | 1993 |
Comparison of the secretory response of the nasal mucosa to methacholine and histamine.
Topics: Adult; Atropine; Diphenhydramine; Dose-Response Relationship, Drug; Female; Histamine; Humans; Kinetics; Lidocaine; Male; Methacholine Chloride; Nasal Mucosa; Receptors, Cholinergic; Receptors, Histamine H1; Reflex; Tachyphylaxis; Terfenadine | 1993 |
Hot melt extrusion of acrylic films.
Topics: Acrylic Resins; Diphenhydramine; Drug Carriers; Hot Temperature; Lidocaine; X-Ray Diffraction | 1996 |
Sensitization of Burkholderia cepacia to antibiotics by cationic drugs.
Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; Azithromycin; Burkholderia cepacia; Cations; Ceftazidime; Dibucaine; Diphenhydramine; Drug Therapy, Combination; Famotidine; Gentamicins; Lidocaine; Microbial Sensitivity Tests; Structure-Activity Relationship; Theobromine; Theophylline | 1998 |
Inhibition of Na(+) current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Diclofenac; Diphenhydramine; Histamine H1 Antagonists; In Vitro Techniques; Lidocaine; Membrane Potentials; Models, Molecular; Rats; Rats, Long-Evans; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship; Tripelennamine | 2000 |
Use of headspace solid-phase microextraction (HS-SPME) in hair analysis for organic compounds.
Topics: Antidepressive Agents, Tricyclic; Cannabinoids; Chlormethiazole; Diphenhydramine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Lidocaine; Methadone; Nicotine; Poisoning; Sensitivity and Specificity; Solvents; Substance Abuse Detection; Tramadol | 2000 |
Localized heat urticaria: a clinical study using laser Doppler flowmetry.
Topics: Administration, Topical; Aged; Cimetidine; Diphenhydramine; Female; Histamine; Histamine H1 Antagonists; Hot Temperature; Humans; Laser-Doppler Flowmetry; Lidocaine; Male; Middle Aged; Phenothiazines; Skin; Time Factors; Urticaria | 2001 |
USE OF TRIPELENNAMINE AND DIPHENHYDRAMINE AS LOCAL ANESTHETICS.
Topics: Anesthetics; Anesthetics, Local; Biomedical Research; Dental Care; Diphenhydramine; Drug Hypersensitivity; Epinephrine; Humans; Lidocaine; Tooth Extraction; Tripelennamine | 1964 |
DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL) AS A LOCAL ANESTHETIC IN PROCAINE AND LIDOCAINE SENSITIVE PATIENTS.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics; Anesthetics, Local; Diphenhydramine; Drug Hypersensitivity; Humans; Lidocaine; Procaine; Tooth Extraction; Toxicology | 1964 |
CONDUCTION ANESTHESIA USING DIPHENHYDRAMINE HYDROCHLORIDE.
Topics: Anesthesia; Anesthesia, Conduction; Diphenhydramine; Drug Hypersensitivity; Humans; Lidocaine; Pharmacology; Tooth Extraction; Toxicology | 1964 |
ARTERIAL CARBON DIOXIDE AND OXYGEN TENSIONS DURING SPINAL BLOCK.
Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthesia, Spinal; Blood Gas Analysis; Carbon Dioxide; Cesarean Section; Diphenhydramine; Drug Therapy; Female; Gangrene; Geriatrics; Halothane; Heart Diseases; Humans; Hydroxyzine; Levallorphan; Lidocaine; Lung Diseases; Metaraminol; Methoxamine; Obesity; Oxygen; Oxygen Inhalation Therapy; Pregnancy; Respiration; Surgical Procedures, Operative | 1965 |
On call: I am a 71-year-old man with diabetes and high blood pressure. Ever since I can remember, I've been bothered by painful canker sores two or three times a year. My doctor says they aren't caused by my medication and I think he's right, since the ca
Topics: Aged; Anesthetics, Local; Carboxymethylcellulose Sodium; Diphenhydramine; Drug Combinations; Humans; Lidocaine; Magnesium Oxide; Male; Stomatitis, Aphthous | 2004 |
Survey of topical oral solutions for the treatment of chemo-induced oral mucositis.
Topics: Administration, Buccal; Adrenal Cortex Hormones; Aluminum Hydroxide; Diphenhydramine; Drug Compounding; Drug Utilization Review; Humans; Lidocaine; Magnesium Hydroxide; Mouth Diseases; Mouthwashes; Mucositis; Nystatin; Pharmaceutical Services; Reproducibility of Results; Surveys and Questionnaires | 2005 |
Spinal anesthesia with diphenhydramine and pheniramine in rats.
Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Injections, Spinal; Lidocaine; Male; Nerve Block; Pheniramine; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
A clinical report of the management of episodic idiopathic pruritus occurring during endodontic therapy.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Dental Anxiety; Diazepam; Diphenhydramine; Female; Histamine Antagonists; Humans; Hypercholesterolemia; Hypnotics and Sedatives; Injections, Intravenous; Lidocaine; Pruritus; Root Canal Therapy; Simvastatin; Time Management | 2013 |
On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system.
Topics: Chemistry, Pharmaceutical; Diazepam; Diphenhydramine; Lidocaine; Pharmaceutical Preparations; Pharmacopoeias as Topic | 2016 |
Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations.
Topics: Administration, Oral; Aluminum Hydroxide; Analgesics; Antineoplastic Agents; Diphenhydramine; Drug Combinations; Drug Compounding; Drug Packaging; Drug Stability; Drug Storage; Humans; Lidocaine; Magnesium Hydroxide; Mouth Mucosa; Mouthwashes; Neoplasms; Simethicone; Stomatitis; Syringes; Temperature | 2017 |
Elucidation of the orientation of selected drugs with 2-hydroxylpropyl-β-cyclodextrin using 2D-NMR spectroscopy and molecular modeling.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Calorimetry, Differential Scanning; Crystallography, X-Ray; Dextromethorphan; Diphenhydramine; Drug Compounding; Excipients; Freeze Drying; Lidocaine; Microscopy, Electron, Scanning; Molecular Docking Simulation; Molecular Dynamics Simulation; Pharmaceutical Preparations; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical | 2018 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
A new sponge-type hydrogel based on hyaluronic acid and poly(methylvinylether-alt-maleic acid) as a 3D platform for tumor cell growth.
Topics: Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Diphenhydramine; Hep G2 Cells; Humans; Hyaluronic Acid; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrogels; Lidocaine; Liver Neoplasms; Maleates; Propranolol | 2020 |
Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic.
Topics: Analgesics; Anesthesia, Local; Anesthetics, Local; Animals; Diphenhydramine; Drug Synergism; Injections, Subcutaneous; Lidocaine; Male; Mannitol; Pain Measurement; Rats; Rats, Sprague-Dawley | 2020 |
SR-FTIR spectro-microscopic interaction study of biochemical changes in HeLa cells induced by Levan-C
Topics: Adsorption; Cell Adhesion; Cell Culture Techniques; Cell Proliferation; Diphenhydramine; Fructans; Glucans; Hep G2 Cells; Humans; Hyaluronic Acid; Hydrogels; Lidocaine; Maleates; Propranolol; Spectroscopy, Fourier Transform Infrared; Synchrotrons | 2020 |
Qualitative LC-Q-TOF Analysis of Umbilical Cord Tissue via Data-Dependent Acquisition as an Indicator of In Utero Exposure to Toxic Adulterating Substances.
Topics: Analgesics, Opioid; Caffeine; Cocaine; Diphenhydramine; Drug Contamination; Female; Humans; Levamisole; Lidocaine; Phenacetin; Pregnancy; Umbilical Cord; Xylazine | 2022 |
Distribution profiles of diphenhydramine and lidocaine in scalp, axillary, and pubic hairs measured by micro-segmental hair analysis: good indicator for discrimination between administration and external contamination of the drugs.
Topics: Diphenhydramine; Emollients; Hair; Humans; Lidocaine; Ointments; Pharmaceutical Preparations; Scalp | 2022 |