lidocaine and dextromethorphan

lidocaine has been researched along with dextromethorphan in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's1 (4.76)18.2507
2000's10 (47.62)29.6817
2010's7 (33.33)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Barecki, M; Casciano, CN; Clement, RP; Johnson, WW; Lew, K; Wang, E1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Mateus, A; Matsson, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dingledine, R; Goldstein, A; Kendig, J1
Abdel-Rahman, MS; Barat, SA1
Ben-Abraham, R; Flaishon, R; Lalayev, G; Niv, D; Weinbroum, AA; Yashar, T1
Weinbroum, AA1
Chang, AS; Cohen, SP; Larkin, T; Mao, J1
Borel, CO; Lee, MS; Liou, HS; Wu, CT; Yang, CP; Yi, HD; Yu, JC1
Chen, YW; Hou, CH; Lin, CN; Lin, MT; Tu, CH; Tzeng, JI; Wang, JJ1
Chen, YW; Chu, CC; Chu, KS; Lin, CN; Lin, MT; Tzeng, JI; Wang, JJ1
Barbera, N; Busardò, FP; Indorato, F; Romano, G1
Gao, XF; He, YL; Hu, C; Mei, YA; Yao, JJ1
Amini, S; Ghalamkari, M; Khatuni, M; Peiman, S; Rahimi, B1
Adhikari, S; Alexander, K; Boddu, SHS; Daftardar, S; Fratev, F; Rivera, M; Sirimulla, S1
Bal, SK; Bhuniya, S; Datta, A; Mohapatra, PR; Panigrahi, MK1
Adamowicz, P; Bigosińska, J; Gil, D; Suchan, M; Tokarczyk, B1

Reviews

1 review(s) available for lidocaine and dextromethorphan

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

6 trial(s) available for lidocaine and dextromethorphan

ArticleYear
Combined pre-incisional oral dextromethorphan and epidural lidocaine for postoperative pain reduction and morphine sparing: a randomised double-blind study on day-surgery patients.
    Anaesthesia, 2001, Volume: 56, Issue:7

    Topics: Aged; Ambulatory Surgical Procedures; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Dextromethorphan; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Follow-Up Studies; Heart Rate; Humans; Lidocaine; Middle Aged; Morphine; Pain, Postoperative; Respiration

2001
Dextromethorphan reduces immediate and late postoperative analgesic requirements and improves patients' subjective scorings after epidural lidocaine and general anesthesia.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:6

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Dextromethorphan; Diclofenac; Double-Blind Method; Female; Hernia, Inguinal; Humans; Lidocaine; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Preanesthetic Medication

2002
The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic pain.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:6

    Topics: Administration, Oral; Adult; Anesthetics, Local; Databases, Factual; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Humans; Injections, Intravenous; Ketamine; Lidocaine; Male; Middle Aged; Pain; Pain Measurement; Peripheral Nervous System Diseases; Predictive Value of Tests; Receptors, N-Methyl-D-Aspartate; ROC Curve

2004
The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy.
    Anesthesia and analgesia, 2005, Volume: 100, Issue:2

    Topics: Analgesics, Opioid; Anesthetics, Local; Cholecystectomy, Laparoscopic; Dextromethorphan; Digestive System; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Injections, Intravenous; Lidocaine; Male; Meperidine; Middle Aged; Pain Measurement; Pain, Postoperative

2005
The Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy: A Randomized, Double-blind, Placebo-controlled Trial.
    Journal of bronchology & interventional pulmonology, 2017, Volume: 24, Issue:4

    Topics: Analgesics; Anesthetics, Local; Anti-Anxiety Agents; Antitussive Agents; Anxiety; Bronchoscopy; Cough; Dextromethorphan; Female; Humans; Hypnotics and Sedatives; Lidocaine; Male; Midazolam; Middle Aged; Patient Satisfaction; Premedication; Prospective Studies

2017
Dextromethorphan premedication in the alleviation of cough during flexible bronchoscopy in adults: A randomized double-blind placebo-controlled trial.
    Respirology (Carlton, Vic.), 2023, Volume: 28, Issue:5

    Topics: Adolescent; Adult; Bronchoscopy; Cough; Dextromethorphan; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Premedication

2023

Other Studies

14 other study(ies) available for lidocaine and dextromethorphan

ArticleYear
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.
    Chemical research in toxicology, 2001, Volume: 14, Issue:12

    Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Mice; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Substrate Specificity

2001
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2014
Effects of narcotic opiates and serotonin on the electrical behavior of neurons in the guinea pig myenteric plexus.
    Life sciences, 1974, Jun-01, Volume: 14, Issue:11

    Topics: Acetylcholine; Action Potentials; Animals; Antitussive Agents; Dextromethorphan; Electric Stimulation; Guinea Pigs; Ileum; Levorphanol; Lidocaine; Male; Morphinans; Morphine; Muscle, Smooth; Naloxone; Neurons; Serotonin; Structure-Activity Relationship

1974
Decreased cocaine- and lidocaine-induced seizure response by dextromethorphan and DNQX in rat.
    Brain research, 1997, May-09, Volume: 756, Issue:1-2

    Topics: Anesthetics, Local; Animals; Cocaine; Dextromethorphan; Excitatory Amino Acid Antagonists; Incidence; Injections, Intravenous; Lidocaine; Male; Narcotics; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures

1997
Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats.
    European journal of pharmacology, 2006, Aug-21, Volume: 544, Issue:1-3

    Topics: Anesthetics, Local; Animals; Area Under Curve; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Lidocaine; Male; Nerve Block; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Time Factors

2006
Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:5

    Topics: Analgesia; Anesthetics, Local; Animals; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Injections, Subcutaneous; Lethal Dose 50; Lidocaine; Male; Pain Measurement; Rats; Rats, Sprague-Dawley

2007
The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome.
    Forensic science international, 2013, Apr-10, Volume: 227, Issue:1-3

    Topics: Adult; Anesthetics, Local; Antitussive Agents; Bile; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Citalopram; Codeine; Dextromethorphan; Drug Contamination; Drug Overdose; Drug Users; Female; Forensic Pathology; Forensic Toxicology; Gastrointestinal Contents; Humans; Illicit Drugs; Kidney; Lidocaine; Liver; Lung; Male; Methadone; Morphine; Morphine Derivatives; Narcotics; Pyrrolidines; Selective Serotonin Reuptake Inhibitors; Substance-Related Disorders; Vitreous Body

2013
Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclic AMP-Dependent Protein Kinases; Dextromethorphan; GTP-Binding Proteins; Guanidines; HEK293 Cells; Humans; Ion Channel Gating; Lidocaine; Muscle Proteins; Mutagenesis, Site-Directed; Mutant Proteins; Mutation; NAV1.2 Voltage-Gated Sodium Channel; Neurons; Phenazocine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, sigma; Sigma-1 Receptor; Signal Transduction; Sodium Channels; Transfection

2012
Elucidation of the orientation of selected drugs with 2-hydroxylpropyl-β-cyclodextrin using 2D-NMR spectroscopy and molecular modeling.
    International journal of pharmaceutics, 2018, Jul-10, Volume: 545, Issue:1-2

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Calorimetry, Differential Scanning; Crystallography, X-Ray; Dextromethorphan; Diphenhydramine; Drug Compounding; Excipients; Freeze Drying; Lidocaine; Microscopy, Electron, Scanning; Molecular Docking Simulation; Molecular Dynamics Simulation; Pharmaceutical Preparations; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical

2018
Drugs detection in fingerprints.
    Journal of pharmaceutical and biomedical analysis, 2024, Jan-20, Volume: 238

    Topics: Chromatography, Liquid; Codeine; Dextromethorphan; Humans; Hydroxyzine; Lidocaine; Pharmaceutical Preparations; Pseudoephedrine; Sertraline; Substance Abuse Detection; Tandem Mass Spectrometry; Trazodone

2024