lidocaine has been researched along with caffeine in 95 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 24 (25.26) | 18.7374 |
1990's | 13 (13.68) | 18.2507 |
2000's | 27 (28.42) | 29.6817 |
2010's | 24 (25.26) | 24.3611 |
2020's | 7 (7.37) | 2.80 |
Authors | Studies |
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Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
Duffy, EM; Jorgensen, WL | 1 |
Topliss, JG; Yoshida, F | 1 |
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
Jolivette, LJ; Ward, KW | 1 |
Carrupt, PA; Martel, S; Ottaviani, G | 2 |
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
Ahman, M; Holmén, AG; Wan, H | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Glen, RC; Lowe, R; Mitchell, JB | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Sen, S; Sinha, N | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Chłoń-Rzepa, G; Dąbrowska, M; Jankowska, A; Komsta, Ł; Pawłowski, M; Ślusarczyk, M; Starek, M; Zagórska, A | 1 |
Moffat, AC | 1 |
Clarke, IM; Ellis, FR | 1 |
Druckenbrod, RW; Mendenhall, CL; Myre, SA; Schroeder, TJ; Stanberry, EA | 1 |
Suarez-Kurtz, G; Sudo, RT; Zapata-Sudo, G | 1 |
Weiss, M | 1 |
Barstow, L; Small, RE | 1 |
Inomata, N; Ishihara, T | 1 |
Gomez, J; Rodriguez, A | 1 |
Kosumian, VK | 1 |
Appell, LH; Blythe, LL; Craig, AM; Slizeski, ML | 1 |
Ahn, HY; Karaki, H; Urakawa, N | 1 |
Klatt, EC; Montgomery, S; Namiki, T; Noguchi, TT | 1 |
Clodi, PH; Hartl, O | 1 |
Inesi, G; Johnson, PN | 1 |
Deptalla, H; Wiegershausen, B | 1 |
Camu, F | 1 |
Denborough, MA; Moulds, RF | 1 |
Doutre, LP; Périssat, J | 1 |
Brimblecombe, RW; Webb, SN | 1 |
Bagnasco, G; Cometti, A; Maggi, N | 1 |
Bianchi, CP; Strobel, GE | 1 |
Bianchi, CP; Novotny, I | 1 |
Bianchi, CP; Bolton, TC | 1 |
Wali, FA | 1 |
Bozkurt, A; Onur, R | 1 |
Jakovljević, V | 1 |
Herlofson, BB; Røed, A | 1 |
Hassanein, T; Van Thiel, DH | 1 |
Arvela, P; Mustajoki, P; Mustajoki, S; Pelkonen, O; Rautio, A | 1 |
Hamilton, J | 1 |
Ishikawa, A; Misawa, S; Tanaka, E | 1 |
Duncan, CJ; Harding, RJ | 1 |
Campos, E; Chayet, L; Collados, L; García, L; Kettlun, AM; Traverso-Cori, A; Valenzuela, MA | 1 |
De Giovanni, N; Fucci, N | 1 |
Amirav, A; Dagan, S; Shahar, T | 1 |
Baker, AB; Gao, L; Ramzan, I | 1 |
MIYABE, I; SUGIYAMA, S | 1 |
Mano, Y; Miyamoto, K; Nomura, M; Takeshita, H; Watanabe, M; Yokogawa, K | 1 |
Kaiho, F; Nikko, H; Suzuki, J; Suzuki, M; Wada, H; Yamaguchi, K | 1 |
Guy, RH; Kalia, YN; Sekkat, N | 1 |
Brockmöller, J; Coupez, R; Lochs, H; Roots, I; Thomsen, T; Wittstock, M | 1 |
Danylovych, IuV | 1 |
Homma, M; Inoue, J; Kato, H; Murata, K; Ogasawara, T; Takeuchi, S | 1 |
Kapur, R; Smith, MD | 1 |
Cadet-Taïrou, A; Evrard, I; Legleye, S | 1 |
Michniak-Kohn, B; Zhang, J | 1 |
Barbera, N; Busardò, FP; Indorato, F; Romano, G | 1 |
Bustillos, JO; Carvalho, DG; Carvalho, VM; Chasin, AA; Diaz, E; Fukushima, AR; Spinosa, Hde S | 1 |
Ferrão, MF; Marcelo, MC; Mariotti, KC; Ortiz, RS | 1 |
de Bairros, AV; dos Santos, A; Lapachinske, SF; Okai, GG; Yonamine, M | 1 |
Caffarel-Salvador, E; Donnelly, RF; McCarthy, HO; McElnay, JC; Mooney, K; Tuan-Mahmood, TM; Woolfson, AD | 1 |
Augusti, R; De Carvalho, TC; Filgueiras, PR; França, HS; Merlo, BB; Ortiz, RS; Rodrigues, RR; Romão, W; Santos, H; Souza, LM; Tosato, F; Vaz, BG | 1 |
Costa, HB; de Souza, LM; Filgueiras, PR; Merlo, BB; Poppi, RJ; Rodrigues, RR; Romão, W; Santos, H; Vaz, BG | 1 |
Chiba, K; Haraya, K; Kato, M; Sugiyama, Y | 1 |
Vargas, RA | 1 |
Anzanello, MJ; Ferrão, MF; Fogliatto, FS; Kahmann, A; Marcelo, MCA; Mariotti, KC; Ortiz, RS | 1 |
Almeida, TS; Carvalho, JPF; Freire, CSR; Mota, JP; Rosado, C; Silva, NHCS; Silvestre, AJD; Vilela, C | 1 |
Chan, P; Chen, CY; Leung, YM; Shiao, LR; Wong, KL; Wu, KC | 1 |
Arana, VA; Arango-Meriño, L; Granados-Reyes, J; Mancera-Barros, J; Quevedo-Castro, C; Sarmiento-Gutiérrez, ÁE | 1 |
Browne, T; Cervantes, A; Logan, BK; Nelson, BN; Strathmann, FG | 1 |
Abuohashish, H; Alabdulsalam, Z; Alfaraj, R; Alfaraj, Z; Alhawaj, H; Alsunni, H; Omar, O | 1 |
Dick, JE; Kong, EF; Krushinski, LE; Vannoy, KJ | 1 |
3 review(s) available for lidocaine and caffeine
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Assessment of liver function: the current situation.
Topics: Caffeine; Cytochrome P-450 Enzyme System; Humans; Lidocaine; Liver; Liver Circulation; Liver Diseases; Liver Function Tests; Metabolic Clearance Rate; Protein Binding | 1995 |
Potential use of pharmacological markers to quantitatively assess liver function during liver transplantation surgery.
Topics: Adult; Antipyrine; Biomarkers; Breath Tests; Caffeine; Coloring Agents; Galactose; Humans; Indocyanine Green; Lidocaine; Liver; Liver Function Tests; Liver Transplantation; Postoperative Period; Reference Values | 2000 |
1 trial(s) available for lidocaine and caffeine
Article | Year |
---|---|
Pharmacokinetics of levetiracetam in patients with moderate to severe liver cirrhosis (Child-Pugh classes A, B, and C): characterization by dynamic liver function tests.
Topics: Adult; Anticonvulsants; Caffeine; Humans; Kidney Function Tests; Levetiracetam; Lidocaine; Liver Cirrhosis, Alcoholic; Liver Function Tests; Male; Middle Aged; Piracetam; Sorbitol | 2005 |
91 other study(ies) available for lidocaine and caffeine
Article | Year |
---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water | 2006 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity.
Topics: Analgesics; Benzeneacetamides; Cyclic Nucleotide Phosphodiesterases, Type 7; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Phenylbutyrates; Phosphodiesterase 4 Inhibitors; Principal Component Analysis; Quantitative Structure-Activity Relationship; TRPA1 Cation Channel; Xanthines | 2021 |
The standardisation of thin-layer chromatographic systems for the identification of basic drugs.
Topics: Amitriptyline; Amphetamine; Caffeine; Chromatography, Thin Layer; Codeine; Hydrogen-Ion Concentration; Lidocaine; Meperidine; Pharmaceutical Preparations; Quinine; Silicon Dioxide; Solvents; Strychnine | 1975 |
An evaluation of procaine in the treatment of malignant hyperpyrexia.
Topics: Anesthesia, General; Animals; Caffeine; Contracture; Dose-Response Relationship, Drug; Drug Evaluation; Halothane; Humans; In Vitro Techniques; Lidocaine; Male; Malignant Hyperthermia; Muscle Contraction; Perfusion; Procaine; Rats | 1975 |
Effects of controlled liver injury and ethanol pretreatment on monoethylglycine xylidide formation in the rat.
Topics: Animals; Body Weight; Caffeine; Diet; Ethanol; Half-Life; Hepatectomy; Indocyanine Green; Lidocaine; Liver; Male; Organ Size; Rats; Rats, Inbred Strains; Regression Analysis | 1991 |
Halothane cooling contractures of skinned mammalian muscle fibers.
Topics: Action Potentials; Animals; Caffeine; Calcium; Cold Temperature; Halothane; In Vitro Techniques; Lidocaine; Muscle Contraction; Muscles; Procaine; Rabbits; Sarcoplasmic Reticulum | 1990 |
Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction.
Topics: Absorption; Antipyrine; Biological Availability; Caffeine; Diphenhydramine; Dose-Response Relationship, Drug; Humans; Ketanserin; Lidocaine; Liver Diseases; Metronidazole; Nomifensine; Triamterene | 1990 |
Liver function assessment by drug metabolism.
Topics: Acetamides; Adult; Allopurinol; Aminopyrine; Caffeine; Half-Life; Humans; Indocyanine Green; Lidocaine; Liver; Liver Circulation; Liver Diseases; Liver Function Tests; Metabolic Clearance Rate; Middle Aged; Oxypurinol; Pyrimidines; Sorbitol | 1990 |
Mechanism of inhibition by SUN 1165, a new Na channel blocking antiarrhythmic agent, of cardiac glycoside-induced triggered activity.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Caffeine; Dogs; Egtazic Acid; Electric Stimulation; Female; Heart Conduction System; In Vitro Techniques; Ion Channels; Lidocaine; Male; Perfusion; Purkinje Fibers; Strophanthidin | 1988 |
An evaluation of the results of a drug sample analysis.
Topics: Amphetamines; Caffeine; Cocaine; Drug Contamination; Heroin; Humans; Illicit Drugs; Lidocaine; Methaqualone; Phenobarbital; Procaine; Spain; Substance-Related Disorders | 1989 |
[Experience using spinal anesthesia in a central regional hospital].
Topics: Acetanilides; Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Spinal; Caffeine; Ephedrine; Evaluation Studies as Topic; Hospitals, District; Humans; Lidocaine; Middle Aged; Preanesthetic Medication; Procaine; Russia; Surgical Procedures, Operative; Trimecaine | 1985 |
Evaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals.
Topics: Acepromazine; Animals; Apomorphine; Caffeine; Chromatography, Thin Layer; Clonixin; Cocaine; Dimethyl Sulfoxide; Drug Interactions; Female; Furosemide; Horses; Lidocaine; Pharmaceutical Preparations; Phenylbutazone | 1987 |
Caffeine-induced contraction in vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Caffeine; Calcium; In Vitro Techniques; Lidocaine; Magnesium; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Potassium; Procaine; Rabbits; Verapamil | 1987 |
Misrepresentation of stimulant street drugs: a decade of experience in an analysis program.
Topics: Adult; Amphetamines; Caffeine; Cocaine; Ephedrine; Humans; Illicit Drugs; Lidocaine | 1986 |
[Therapy of arrhythmias].
Topics: Ajmaline; Arrhythmias, Cardiac; Atrial Fibrillation; Bradycardia; Caffeine; Cardiac Complexes, Premature; Digitalis Glycosides; Heart Block; Humans; Lidocaine; Metaproterenol; Phenytoin; Procainamide; Tachycardia; Ventricular Fibrillation; Verapamil | 1973 |
The effect of methylxanthines and local anesthetics on fragmented sarcoplasmic reticulum.
Topics: Adenosine Triphosphatases; Aminophylline; Anesthetics, Local; Animals; Biological Transport, Active; Caffeine; Calcium; Cell Membrane Permeability; Endoplasmic Reticulum; Hot Temperature; Lidocaine; Muscles; Procaine; Rabbits; Tetracaine; Theophylline; Veratrine; Xanthines | 1969 |
[Influence of local anesthetics on the excitation activity of bradykinin on smooth muscle. II. Potentiation of bradykinin contraction in the guinea pig ileum].
Topics: Acetylcholine; Aminocaproates; Anesthetics, Local; Angiotensin II; Animals; Bradykinin; Caffeine; Cocaine; Drug Synergism; Eledoisin; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Procaine; Serotonin; Tetracaine | 1969 |
Effects of local anesthetics on glucose-stimulated insulin secretion from rat pancreas in vitro.
Topics: Anesthetics, Local; Animals; Antigens; Bupivacaine; Caffeine; Calcium; Cyclic AMP; Dibucaine; Glucose; In Vitro Techniques; Insulin; Insulin Antibodies; Insulin Secretion; Lidocaine; Mepivacaine; Neutralization Tests; Pancreas; Potassium; Prilocaine; Procaine; Rats; Stimulation, Chemical; Tetracaine | 1973 |
Procaine in malignant hyperpyrexia.
Topics: Aged; Caffeine; Female; Halothane; Humans; In Vitro Techniques; Lidocaine; Malignant Hyperthermia; Muscle Contraction; Procaine; Relaxation | 1972 |
[Propofan as an antalgic in general surgery. Apropos of 50 cases].
Topics: Acetaminophen; Analgesics; Aspirin; Bone Diseases; Caffeine; Chlorpheniramine; Dextropropoxyphene; Drug Combinations; Fractures, Bone; Humans; Lidocaine; Peritoneal Diseases; Postoperative Care; Suppositories; Tablets; Wounds and Injuries | 1972 |
Further studies on the interaction between acetylcholine antagonists and anticholinesterases on cat soleus muscle.
Topics: Acetylcholine; Animals; Caffeine; Carboxylic Acids; Cats; Cholinesterase Inhibitors; Drug Interactions; Glycolates; Lidocaine; Muscle Contraction; Muscles; Neostigmine; Piperidines; Sarin; Stereoisomerism | 1973 |
GLC analysis of multicomponent suppository formulations.
Topics: Acetaminophen; Amides; Aminopyrine; Aspirin; Benzoates; Caffeine; Chlorpheniramine; Chromatography, Gas; Dextropropoxyphene; Ethylamines; Lidocaine; Malonates; Phenacetin; Sulfadimethoxine; Suppositories | 1971 |
An in-vitro model of anesthetic hypertonic hyperpyrexia, halothane--caffeine-induced muscle contractures: prevention of contracture by procainamide.
Topics: Anesthesia, Inhalation; Animals; Anura; Caffeine; Culture Techniques; Drug Synergism; Fever; Halothane; Lidocaine; Models, Biological; Muscle Contraction; Procainamide; Rana pipiens; Sarcoplasmic Reticulum; Time Factors | 1971 |
The effect of xylocaine on oxygen consumption in the frog sartorius.
Topics: Animals; Anura; Caffeine; Calcium; Hydrogen-Ion Concentration; In Vitro Techniques; Lidocaine; Muscle Contraction; Muscles; Oxygen Consumption; Potassium | 1967 |
Action of local anesthetics on coupling systems in muscle.
Topics: Action Potentials; Animals; Anura; Caffeine; Carbon Isotopes; Drug Synergism; Electrophysiology; Extracellular Space; Hydrogen-Ion Concentration; In Vitro Techniques; Lidocaine; Muscle Contraction; Muscles; Procaine; Tetracaine | 1967 |
The effects and interactions of caffeine, lignocaine and carbachol at the chick neuromuscular junction.
Topics: Animals; Caffeine; Calcium; Carbachol; Chickens; Dose-Response Relationship, Drug; In Vitro Techniques; Lidocaine; Muscle Contraction; Neuromuscular Junction; Tetraethylammonium Compounds | 1984 |
The effects of sodium selenite on rat diaphragm muscle.
Topics: Animals; Caffeine; Diaphragm; Electric Stimulation; Female; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Muscles; Potassium Chloride; Procaine; Rats; Selenious Acid; Selenium; Tetrodotoxin | 1983 |
[The effect of methylxanthine on myocardial excitability].
Topics: Animals; Caffeine; Female; Guinea Pigs; Heart Rate; Lidocaine; Male; Pentoxifylline; Xanthines | 1982 |
Inhibitory effects of HgCl2 on excitation-secretion coupling at the motor nerve terminal and excitation-contraction coupling in the muscle cell.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Caffeine; Calcium; Dantrolene; Diaphragm; Electric Stimulation; In Vitro Techniques; Lidocaine; Magnesium; Mercuric Chloride; Methylmercury Compounds; Motor Neurons; Muscle Contraction; Muscle, Skeletal; Nerve Endings; Phrenic Nerve; Potassium Chloride; Rats; Rats, Wistar; Ruthenium Red; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and in healthy men.
Topics: Adult; Arginine; Caffeine; Coumarins; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Heme; Humans; Isoenzymes; Lidocaine; Male; Middle Aged; Porphyrias, Hepatic; Reference Values | 1994 |
Premature babies and pharmacology.
Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Central Nervous System Stimulants; Drug Combinations; Humans; Ibuprofen; Infant, Newborn; Infant, Premature; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pharmacology; Prilocaine | 1995 |
Changes in the metabolism of three model substrates catalysed by different P450 isozymes when administered as a cocktail to the carbon tetrachloride-intoxicated rat.
Topics: Animals; Biotransformation; Caffeine; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Hydantoins; Injections, Intravenous; Isoenzymes; Lidocaine; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Theophylline | 1995 |
Protective effect of lidocaine on cell damage in the perfused rat heart.
Topics: Animals; Caffeine; Calcium; Creatine Kinase; Drug Synergism; Heart; Lidocaine; Myocardium; Oxygen; Perfusion; Rats; Rats, Wistar | 1996 |
Human placental ecto-enzymes: studies on the plasma membrane anchorage and effect of inhibitors of ATP-metabolizing enzymes.
Topics: 5'-Nucleotidase; Alkaline Phosphatase; Amitriptyline; Apyrase; Caffeine; Cell Membrane; Endopeptidases; Enzyme Inhibitors; Female; Fluphenazine; Glycosylphosphatidylinositols; Humans; Lidocaine; Microvilli; Nucleotides; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase D; Placenta; Type C Phospholipases | 1997 |
Adulterants encountered in the illicit cocaine market.
Topics: Caffeine; Central Nervous System Stimulants; Cocaine; Drug Contamination; Gas Chromatography-Mass Spectrometry; Illicit Drugs; Lidocaine; Rome | 1998 |
Laser desorption fast gas chromatography-mass spectrometry in supersonic molecular beams.
Topics: Caffeine; Gas Chromatography-Mass Spectrometry; Humans; Lasers; Lidocaine; Pesticides; Pharmaceutical Preparations; Plant Leaves; Spectrometry, Mass, Fast Atom Bombardment; Water Supply | 1998 |
[CASE OF SUCCESSFUL TREATMENT OF SHOCK IN TONSILLECTOMY AND MEASURES FOR PREVENTING IT].
Topics: Blood Sedimentation; Blood Transfusion; Caffeine; Cyanosis; Drug Hypersensitivity; Electrocardiography; Glycosuria; Infusions, Parenteral; Lidocaine; Oxygen Inhalation Therapy; Procaine; Respiratory Insufficiency; Shock; Shock, Septic; Spasm; Tonsillectomy; Toxicology | 1963 |
Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.
Topics: Animals; Area Under Curve; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Cytochrome P-450 Enzyme System; Half-Life; Isoenzymes; Lidocaine; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats; Rats, Wistar; Tolbutamide; Transaminases | 2004 |
[The problems of multiple-chemical sensitivity patients in using medicinal drugs].
Topics: Adult; Aspirin; Caffeine; Contraindications; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Environmental Exposure; Female; Humans; Lidocaine; Male; Middle Aged; Multiple Chemical Sensitivity; Pharmaceutical Preparations; Surveys and Questionnaires | 2004 |
Porcine ear skin as a model for the assessment of transdermal drug delivery to premature neonates.
Topics: Administration, Cutaneous; Age Factors; Animals; Caffeine; Diffusion; Ear; Humans; In Vitro Techniques; Infant, Newborn; Infant, Premature; Iontophoresis; Lidocaine; Models, Animal; Permeability; Phenobarbital; Skin; Swine | 2004 |
[Characteristics of passive Ca2+ -transport from cells of the myometrium sarcoplasmic reticulum in rats].
Topics: Animals; Biological Transport; Caffeine; Calcium; Cells, Cultured; Female; Hydrogen-Ion Concentration; Lidocaine; Magnesium; Myocytes, Smooth Muscle; Myometrium; Rats; Sarcoplasmic Reticulum | 2007 |
[Case of intractable ventricula fibrillation by a multicomponent dietary supplement containing ephedra and caffeine overdose].
Topics: Adult; Caffeine; Dietary Supplements; Drug Overdose; Drug Synergism; Electric Countershock; Ephedra; Female; Humans; Hypokalemia; Lidocaine; Magnesium; Pyrimidinones; Ventricular Fibrillation | 2007 |
Treatment of cardiovascular collapse from caffeine overdose with lidocaine, phenylephrine, and hemodialysis.
Topics: Adolescent; Anti-Arrhythmia Agents; Caffeine; Cardiotonic Agents; Combined Modality Therapy; Drug Overdose; Electrocardiography; Humans; Lidocaine; Male; Phenylephrine; Renal Dialysis; Suicide, Attempted | 2009 |
Composition, purity and perceived quality of street cocaine in France.
Topics: Acetaminophen; Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Data Collection; Diltiazem; Drug Contamination; Drug Users; Female; France; Humans; Illicit Drugs; Lidocaine; Male; Middle Aged; Smoking; Young Adult | 2010 |
Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine.
Topics: Administration, Cutaneous; Animals; Azepines; Caffeine; Calorimetry, Differential Scanning; Electric Conductivity; Emulsions; Glycerides; Glycerol; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Ketoprofen; Lidocaine; Myristates; Organic Chemicals; Permeability; Skin; Sulfur Compounds; Surface-Active Agents; Swine; Water | 2011 |
The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome.
Topics: Adult; Anesthetics, Local; Antitussive Agents; Bile; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Citalopram; Codeine; Dextromethorphan; Drug Contamination; Drug Overdose; Drug Users; Female; Forensic Pathology; Forensic Toxicology; Gastrointestinal Contents; Humans; Illicit Drugs; Kidney; Lidocaine; Liver; Lung; Male; Methadone; Morphine; Morphine Derivatives; Narcotics; Pyrrolidines; Selective Serotonin Reuptake Inhibitors; Substance-Related Disorders; Vitreous Body | 2013 |
Purity and adulterant analysis of crack seizures in Brazil.
Topics: Aminobenzoates; Benzene; Biphenyl Compounds; Brazil; Caffeine; Chromatography, Gas; Chromatography, Liquid; Crack Cocaine; Cyclooctanes; Drug Contamination; Lidocaine; Mass Spectrometry; Naphthalenes; Nitriles; Pyridines; Smoke | 2014 |
Profiling cocaine by ATR-FTIR.
Topics: Caffeine; Cluster Analysis; Cocaine; Discriminant Analysis; Dopamine Uptake Inhibitors; Drug Contamination; Humans; Lidocaine; Phenacetin; Principal Component Analysis; Spectroscopy, Fourier Transform Infrared | 2015 |
Analysis of cocaine and its adulterants in drugs for international trafficking seized by the Brazilian Federal Police.
Topics: Aminopyrine; Brazil; Caffeine; Cocaine; Crime; Drug Contamination; Gas Chromatography-Mass Spectrometry; Humans; Levamisole; Lidocaine; Narcotics; Phenacetin | 2015 |
Potential of hydrogel-forming and dissolving microneedles for use in paediatric populations.
Topics: Administration, Cutaneous; Adolescent; Analgesics; Animals; Caffeine; Child; Female; Humans; Hydrogels; Lidocaine; Male; Microinjections; Needles; Pain; Pediatrics; Physicians; Public Opinion; Rats, Sprague-Dawley; Skin; Swine; Transdermal Patch | 2015 |
Thin layer chromatography coupled to paper spray ionization mass spectrometry for cocaine and its adulterants analysis.
Topics: Benzocaine; Caffeine; Chromatography, Thin Layer; Cocaine; Drug Contamination; Humans; Lidocaine; Mass Spectrometry; Narcotics; Phenacetin | 2016 |
A survey of adulterants used to cut cocaine in samples seized in the Espírito Santo State by GC-MS allied to chemometric tools.
Topics: Caffeine; Cocaine; Drug Contamination; Gas Chromatography-Mass Spectrometry; Humans; Lidocaine; Narcotics; Principal Component Analysis | 2016 |
Prediction of inter-individual variability on the pharmacokinetics of CYP1A2 substrates in non-smoking healthy volunteers.
Topics: Area Under Curve; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Healthy Volunteers; Humans; Lidocaine; Monte Carlo Method; Phenacetin; Theophylline | 2016 |
Effects of GABA, Neural Regulation, and Intrinsic Cardiac Factors on Heart Rate Variability in Zebrafish Larvae.
Topics: Acetylcholine; Animals; Bicuculline; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Cholinergic Agonists; Dopamine; Dopamine Agents; Ethanol; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Heart; Heart Rate; Larva; Lidocaine; Methacholine Chloride; Muscarinic Agonists; Muscimol; Zebrafish | 2017 |
Wavenumber selection method to determine the concentration of cocaine and adulterants in cocaine samples.
Topics: Caffeine; Cocaine; Drug Contamination; Levamisole; Lidocaine | 2018 |
Topical Drug Delivery Systems Based on Bacterial Nanocellulose: Accelerated Stability Testing.
Topics: Administration, Topical; Bacteria; Biocompatible Materials; Caffeine; Cellulose; Diclofenac; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Stability; Humans; Ibuprofen; Lidocaine; Nanoparticles | 2020 |
Perturbation of Ca
Topics: Adenosine Triphosphate; Anesthetics, Local; Animals; Biological Transport; Caffeine; Calcium; Cell Line, Tumor; Cytosol; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Lidocaine; Macrocyclic Compounds; Mice; Microfluidic Analytical Techniques; Neurons; Oxazoles; Ryanodine Receptor Calcium Release Channel | 2021 |
Cutting agents in cocaine: A temporal study of the period 2015-2017 in the Northern Region of Colombia.
Topics: Aporphines; Caffeine; Cocaine; Codeine; Colombia; Drug Contamination; Drug Trafficking; Humans; Imidazoles; Levamisole; Lidocaine; Phenacetin; Spatio-Temporal Analysis; Tetramisole | 2021 |
Qualitative LC-Q-TOF Analysis of Umbilical Cord Tissue via Data-Dependent Acquisition as an Indicator of In Utero Exposure to Toxic Adulterating Substances.
Topics: Analgesics, Opioid; Caffeine; Cocaine; Diphenhydramine; Drug Contamination; Female; Humans; Levamisole; Lidocaine; Phenacetin; Pregnancy; Umbilical Cord; Xylazine | 2022 |
Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study.
Topics: Anesthetics, Local; Animals; Caffeine; Drug Interactions; Humans; Lidocaine; Pain; Rats; Rats, Wistar; Voltage-Gated Sodium Channels | 2022 |
Reagentless Voltammetric Identification of Cocaine from Complex Powders.
Topics: Benzocaine; Caffeine; Carbon Fiber; Cocaine; Levamisole; Lidocaine; Powders; Procaine; Water | 2022 |