lidocaine has been researched along with 2,6-xylidine in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Nelson, SD; Nelson, WL; Trager, WF | 1 |
| Kwapiszewski, W; Piranowicz-Chaber, E; Skulski, L | 1 |
| Kwapiszewski, W; Pirianowicz-Chaber, E; Skulski, L | 1 |
| Smith, DJ | 1 |
| Bryant, MS; Harrell, RE; Hinson, JA; Simmons, HF | 1 |
| Beardsley, T | 1 |
| Collins, JM; Parker, RJ; Strong, JM | 1 |
| Friskopp, J; Huledal, G | 1 |
| Duan, JD; Jeffrey, AM; Williams, GM | 1 |
| Boyne, MT; Colatsky, T; Hartman, NR; Mao, JJ; Patel, V; Racoosin, JA; Taylor, K; Wasserman, AM; Zhou, H | 1 |
| Bulder, AS; Essers, M; Hoogenboom, RL; Mengelers, MJ; van Eijkeren, JC; van Vuuren, AM; van Wikselaar, PG; Zeilmaker, MJ; Zuidema, T | 1 |
| Bakhtiar, R; Engel, BJ; Green, C; King, B; Li, Q; Magers, T; Shoup, R | 1 |
| Abdel-Rehim, M; Hadjmohammadi, M; Karimiyan, H; Moein, MM; Uheida, A | 1 |
| Johnson, GE; Kirkland, DJ; Sheil, ML; Streicker, MA | 1 |
| Essers, M; Hoogenboom, R; Lautz, L; Pinckaers, N; Punt, A; Rijkers, D; Stoopen, G | 1 |
| Abdelshafi, NA; Attia, KAM; Eid, SM; El-Olemy, A; Emad F Abbas, A | 1 |
1 review(s) available for lidocaine and 2,6-xylidine
| Article | Year |
|---|---|
A weight of evidence assessment of the genotoxicity of 2,6-xylidine based on existing and new data, with relevance to safety of lidocaine exposure.
Topics: Activation, Metabolic; Anesthetics, Local; Aniline Compounds; Animals; Humans; Lidocaine; Mutagenicity Tests; Mutagens | 2021 |
15 other study(ies) available for lidocaine and 2,6-xylidine
| Article | Year |
|---|---|
N-Hydroxyamide metabolites of lidocaine. Synthesis, characterization, quantitation, and mutagenic potential.
Topics: Animals; Carcinogens; Deuterium; Humans; Isotope Labeling; Lidocaine; Mass Spectrometry; Mice; Mutagens; Salmonella; Stereoisomerism | 1978 |
[Amino acid derivatives of 2,6 and p-aminobenzoic acid. I. Synthesis of derivatives of 2,6-xylidine and various derivatives of PAB].
Topics: 4-Aminobenzoic Acid; Aniline Compounds; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chemical Phenomena; Chemistry; Drug Evaluation; Humans; Lidocaine; Procainamide; Tocainide | 1989 |
[Amino acid derivatives of 2,6-xylidine and p-aminobenzoic acid. II. Synthesis of derivatives of N-(p-aminobenzoylaminoalkylacyl)-2,6-xylidines and study of their resistance to proteolytic factors].
Topics: Aniline Compounds; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Drug Resistance; Gastric Juice; Humans; Hydrolysis; In Vitro Techniques; Lidocaine; Pancreatin; Pepsin A; Tocainide | 1989 |
Determination and temperature effects of lidocaine (lignocaine) hydrochloride, epinephrine, methylparaben, 2,6-dimethylaniline, and p-hydroxybenzoic acid in USP lidocaine injection by ion-pair reversed-phase high pressure liquid chromatography.
Topics: Aniline Compounds; Chromatography, High Pressure Liquid; Drug Packaging; Epinephrine; Humans; Hydroxybenzoates; Lidocaine; Parabens; Quality Control; Reference Values; Temperature; Xylenes | 1981 |
2,6-Dimethylaniline--hemoglobin adducts from lidocaine in humans.
Topics: Aniline Compounds; Animals; Dose-Response Relationship, Drug; Hemoglobins; Humans; In Vitro Techniques; Lidocaine; Male; Mice; Mice, Inbred Strains | 1994 |
Take the pain? Lidocaine comes under suspicion as a carcinogen.
Topics: Aniline Compounds; Animals; Carcinogens; Humans; Lidocaine; Rats | 1994 |
Identification of 2,6-xylidine as a major lidocaine metabolite in human liver slices.
Topics: Aniline Compounds; Biotransformation; Gas Chromatography-Mass Spectrometry; Humans; Lidocaine; Models, Chemical | 1996 |
Plasma levels of lidocaine and prilocaine after application of Oraqix, a new intrapocket anesthetic, in patients with advanced periodontitis.
Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Aniline Compounds; Chromatography, Liquid; Dental Scaling; Female; Follow-Up Studies; Gels; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Linear Models; Male; Mass Spectrometry; Middle Aged; Mouthwashes; Periodontal Pocket; Periodontitis; Prilocaine; Regression Analysis; Root Planing; Safety; Toluidines; Water | 2001 |
Assessment of the medicines lidocaine, prilocaine, and their metabolites, 2,6-dimethylaniline and 2-methylaniline, for DNA adduct formation in rat tissues.
Topics: Aniline Compounds; Animals; DNA Adducts; Lidocaine; Male; Prilocaine; Rats; Rats, Inbred F344; Toluidines | 2008 |
More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems.
Topics: Anesthetics, Local; Aniline Compounds; Benzocaine; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Lidocaine; Liver; Methemoglobin; Methemoglobinemia | 2014 |
Concentrations of dimethylaniline and other metabolites in milk and tissues of dairy cows treated with lidocaine.
Topics: Aniline Compounds; Animals; Carcinogens; Cattle; Cattle Diseases; Female; Food Contamination; Lidocaine; Meat; Milk; Mutagens; Time Factors | 2015 |
Measurement of lidocaine and 2,6-dimethylaniline in minipig plasma, skin, and dermal tapes using UHPLC with electrospray MS/MS.
Topics: Adhesives; Administration, Cutaneous; Aniline Compounds; Animals; Chromatography, High Pressure Liquid; Female; Lidocaine; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Skin; Swine; Tandem Mass Spectrometry | 2018 |
Polyacrylonitrile / graphene oxide nanofibers for packed sorbent microextraction of drugs and their metabolites from human plasma samples.
Topics: Acrylic Resins; Anesthetics, Local; Aniline Compounds; Chromatography, Liquid; Graphite; Humans; Hydrogen-Ion Concentration; Lidocaine; Limit of Detection; Nanofibers; Prilocaine; Solid Phase Microextraction; Tandem Mass Spectrometry; Toluidines | 2019 |
In vitro metabolism of lidocaine in subcellular post-mitochondrial fractions and precision cut slices from cattle liver.
Topics: Anesthetics, Local; Aniline Compounds; Animals; Biotransformation; Cattle; In Vitro Techniques; Lidocaine; Liver; Mitochondria; Subcellular Fractions | 2021 |
An innovative nanoparticle-modified carbon paste sensor for ultrasensitive detection of lignocaine and its extremely carcinogenic metabolite residues in bovine food samples: Application of NEMI, ESA, AGREE, ComplexGAPI, and RGB12 algorithms.
Topics: Animals; Carbon; Carcinogens; Cattle; Electrochemical Techniques; Electrodes; Lidocaine; Nanoparticles; Spectroscopy, Fourier Transform Infrared | 2023 |