licochalcone-b has been researched along with derrone* in 1 studies
1 other study(ies) available for licochalcone-b and derrone
| Article | Year |
|---|---|
Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury.
Licorice and its constituents, especially licorice flavonoids have been reported to possess significant hepatoprotective activities. However, previous studies mainly focus on the extract and major compounds, and few reports are available on other licorice compounds.. This work aims to evaluate the in vitro hepatoprotective activities of licorice compounds and screen active compounds, and to establish the structure-activity relationship.. A compound library consisting of 180 compounds from three medicinal licorice species, Glycyrrhiza uralensis, G. glabra and G. inflata was established. HepG2 cells were incubated with the compounds, together with the treatment of 0.35% CCl. A total of 62 compounds at 10 µM showed protective effects against CCl. Compounds 5, 76, 104, 107, 111, 118 and 144 possess potent activities against both CCl Topics: Acetaminophen; Carbon Tetrachloride; Chalcones; Chemical and Drug Induced Liver Injury; Flavonoids; Glycyrrhiza; Hep G2 Cells; Humans; Liver; Molecular Structure; Phenols; Plant Extracts; Protective Agents; Structure-Activity Relationship | 2017 |