Compounds > liarozole
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liarozole and tretinoin

liarozole has been researched along with tretinoin in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's23 (58.97)18.2507
2000's11 (28.21)29.6817
2010's5 (12.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brodie, AM; Clement, OO; Gediya, LK; Goloubeva, OG; Handratta, VD; Huynh, CK; Nanne, IP; Njar, VC; Patel, JB; Soprano, DR1
Cheng, M; Hao, C; Li, F; Lv, X; Ren, J; Song, S; Sun, B; Zhao, D1
Cheng, MS; Han, J; Lin, B; Liu, K; Su, X; Sun, B; Zhao, DM; Zhao, LY1
Borghgraef, P; Coene, MC; Cools, W; Goossens, J; Janssen, PA; Stoppie, P; Van Nyen, G; Van Wauwe, J1
Bowden, C; Coene, MC; De Coster, R; End, D; Krekels, M; Van Ginckel, R; Wouters, W1
Coene, MC; Cools, W; De Coster, R; Dillen, A; van Dun, J; Wouters, W1
Coene, MC; Cools, W; Goossens, J; Monbaliu, J; Van Wauwe, JP1
Acevedo, P; Bertram, JS1
Borgers, M; Coene, MC; Daneels, G; De Coster, R; Moeremans, M; Ramaekers, FC; Schalken, JA; Smets, G; Van Ginckel, R; Van Wauwe, J1
Kris, MG; Miller, VA; Muindi, JR; Rigas, JR; Tong, WP; Venkatraman, E; Warrell, RP1
Coene, MC; Cools, W; Goossens, J; Lauwers, W; Le Jeune, L; Van Hove, C; Van Nyen, G; Van Wauwe, J1
Decree, J; Degreef, H; Dockx, P1
Bruynseels, J; De Coster, R; Wouters, W1
Cromie, MA; Elder, JT; Kang, S; Kaplan, A; Voorhees, JJ1
Coene, MC; Cools, W; Janssens, B; Krekels, MD; Van Ginckel, R; Van Hove, C; Wouters, W; Zimmerman, J1
Duell, EA; Kang, S; Kim, KJ; Voorhees, JJ1
Hall, AK1
Borgers, M; De Coster, R; Ramaekers, F; Smets, G; Van heusden, J; Wouters, W; Xhonneux, B1
de Rooij, DG; Gaemers, IC; Hoogerbrugge, JW; Themmen, AP; van der Saag, PT; van Pelt, AM1
Coene, MC; Cools, W; Dillen, L; Krekels, MD; van Dun, J; Van Hove, C; Verhoeven, A; Wouters, W1
Borgers, M; Dillen, L; Krekels, MD; Ramaekers, FC; Smets, G; Van heusden, J; Wouters, W1
Petkovich, M; Schulkes, RK; Sonneveld, E; van den Brink, CE; van der Burg, B; van der Leede, BM; van der Saag, PT1
Miller, WH1
De Coster, R; Freyne, E; Raeymaekers, A; Sanz, G; Venet, M; Wauwe, JV; Wouters, W1
Mehta, K; Parthasarathy, R1
Maden, M; Sonneveld, E; van den Brink, CE; van der Leede, BJ; van der Saag, PT1
Lotan, R1
Gooding, WE; Grandis, JR; Smith, DC; Suscovich, TJ; Trump, DL; Zeng, Q1
Kauffman, FC; Levin, AA; Pignatello, MA1
Bruwiere, H; Dillen, L; Floren, W; Janicot, M; Janssen, B; Moelans, P; Sanz, G; van der Leede, BJ; van Dun, J; Van Ginckel, R; Van Heusden, J; Van Hove, C; Venet, M; Willemsens, G; Wouters, W1
Njar, VC1
Coogan, MP; Jayne, M; Pautus, S; Simons, C; Yee, SW1
van Steensel, MA1
Agudo, M; Connor, S; Corcoran, JP; Goncalves, MB; Maden, M; McMahon, S; Minger, SL1
Blockhuys, S; Borgers, M; Gånemo, A; Pavez Loriè, E; Törmä, H; Vahlquist, A; van de Plassche, L; Wouters, L1
Chamcheu, JC; Pavez Loriè, E; Törmä, H; Vahlquist, A1
Britten, J; Catherino, WH; Delgado, T; Gilden, M; Levy, G; Malik, M1
Endres, M; Freyer, D; Gertz, K; Hellmann-Regen, J; Kronenberg, G; Uhlemann, R1
Akira, S; Amiya, T; Fujisawa, K; Hashimoto, E; Kabashima, K; Kiyono, H; Kogure, Y; Kubo, M; Kunisawa, J; Kurashima, Y; Miyake, K; Otsuka, A; Sato, S; Sato, T; Shibata, N; Suzuki, Y1

Reviews

5 review(s) available for liarozole and tretinoin

ArticleYear
Experimental studies with liarozole (R 75,251): an antitumoral agent which inhibits retinoic acid breakdown.
    The Journal of steroid biochemistry and molecular biology, 1992, Volume: 43, Issue:1-3

    Topics: Animals; Antineoplastic Agents; Cell Division; Humans; Imidazoles; Neoplasms, Experimental; Plasminogen Activators; Testosterone; Tetradecanoylphorbol Acetate; Tretinoin

1992
P450-dependent enzymes as targets for prostate cancer therapy.
    The Journal of steroid biochemistry and molecular biology, 1996, Volume: 56, Issue:1-6 Spec N

    Topics: Adenocarcinoma; Aldehyde-Lyases; Androgen Antagonists; Androgens; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Cattle; Clinical Trials as Topic; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Imidazoles; Ketoconazole; Male; Mice; Neoplasm Proteins; Prostatic Neoplasms; Rats; Rats, Wistar; Salvage Therapy; Steroid 17-alpha-Hydroxylase; Tretinoin; Tumor Cells, Cultured

1996
The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer.
    Cancer, 1998, Oct-15, Volume: 83, Issue:8

    Topics: Antineoplastic Agents; Cell Differentiation; Chemoprevention; Cytochrome P-450 Enzyme Inhibitors; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Imidazoles; Neoplasms; Phenotype; Receptors, Retinoic Acid; Retinoids; Tretinoin

1998
Cytochrome p450 retinoic acid 4-hydroxylase inhibitors: potential agents for cancer therapy.
    Mini reviews in medicinal chemistry, 2002, Volume: 2, Issue:3

    Topics: Animals; Antineoplastic Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Design; Enzyme Inhibitors; Humans; Imidazoles; Retinoic Acid 4-Hydroxylase; Tretinoin

2002
Emerging drugs for ichthyosis.
    Expert opinion on emerging drugs, 2007, Volume: 12, Issue:4

    Topics: Animals; Drug Design; Humans; Ichthyosis; Imidazoles; Keratolytic Agents; Molecular Structure; Tretinoin

2007

Trials

4 trial(s) available for liarozole and tretinoin

ArticleYear
Modulation of all-trans retinoic acid pharmacokinetics by liarozole.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:6

    Topics: Antineoplastic Agents; Humans; Imidazoles; Neoplasms; Tretinoin

1994
Inhibition of the metabolism of endogenous retinoic acid as treatment for severe psoriasis: an open study with oral liarozole.
    The British journal of dermatology, 1995, Volume: 133, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Arthritis, Psoriatic; Female; Humans; Imidazoles; Male; Middle Aged; Psoriasis; Severity of Illness Index; Treatment Outcome; Tretinoin

1995
Determination of intermediate biomarker expression levels by quantitative reverse transcription-polymerase chain reaction in oral mucosa of cancer patients treated with liarozole.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:6

    Topics: Actins; Antineoplastic Agents, Hormonal; Biomarkers; Carcinoma, Squamous Cell; DNA Primers; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Humans; Imidazoles; Mouth Mucosa; Mouth Neoplasms; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor alpha; Tretinoin; Up-Regulation

2000
Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole.
    Acta dermato-venereologica, 2009, Volume: 89, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Aged; Biomarkers; Dermatologic Agents; Double-Blind Method; Female; Humans; Ichthyosis, Lamellar; Imidazoles; Interleukin-1alpha; Male; Middle Aged; Polymerase Chain Reaction; Receptors, Retinoic Acid; RNA, Messenger; Skin; Tretinoin; Tumor Necrosis Factor-alpha

2009

Other Studies

30 other study(ies) available for liarozole and tretinoin

ArticleYear
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
    Journal of medicinal chemistry, 2004, Dec-30, Volume: 47, Issue:27

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Male; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Microsomes, Liver; Neoplasm Transplantation; Prostatic Neoplasms; Retinoic Acid 4-Hydroxylase; Stereoisomerism; Transplantation, Heterologous; Tretinoin

2004
Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1).
    Bioorganic & medicinal chemistry, 2015, Mar-15, Volume: 23, Issue:6

    Topics: Cell Differentiation; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Models, Molecular; Molecular Structure; Phenylpropionates; Retinoic Acid 4-Hydroxylase; Small Molecule Libraries; Structure-Activity Relationship; Tretinoin

2015
Design, synthesis, and biological evaluation of amide imidazole derivatives as novel metabolic enzyme CYP26A1 inhibitors.
    Bioorganic & medicinal chemistry, 2015, Oct-15, Volume: 23, Issue:20

    Topics: Amides; Cell Differentiation; Cell Proliferation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Design; HL-60 Cells; Humans; Imidazoles; Models, Molecular; Molecular Structure; Retinoic Acid 4-Hydroxylase; Structure-Activity Relationship

2015
Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:2

    Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Cricetinae; Female; Imidazoles; Injections, Subcutaneous; Keratins; Mesocricetus; Microsomes, Liver; Ovariectomy; Rats; Rats, Inbred Strains; Tretinoin; Vagina

1992
Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells.
    Cancer research, 1992, May-15, Volume: 52, Issue:10

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cytochrome P-450 Enzyme Inhibitors; Drug Synergism; Female; Humans; Imidazoles; Kinetics; Tretinoin; Tritium; Tumor Cells, Cultured

1992
Effects of cytochrome P-450 inhibitors on the in vivo metabolism of all-trans-retinoic acid in rats.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Imidazoles; Ketoconazole; Male; Rats; Rats, Inbred Strains; Tretinoin

1990
Liarozole potentiates the cancer chemopreventive activity of and the up-regulation of gap junctional communication and connexin43 expression by retinoic acid and beta-carotene in 10T1/2 cells.
    Carcinogenesis, 1995, Volume: 16, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; beta Carotene; Carotenoids; Cell Communication; Cell Transformation, Neoplastic; Cells, Cultured; Connexin 43; Drug Synergism; Fibroblasts; Gap Junctions; Humans; Imidazoles; Mice; Mice, Inbred C3H; Skin; Tretinoin; Up-Regulation

1995
Liarozole, an antitumor drug, modulates cytokeratin expression in the Dunning AT-6sq prostatic carcinoma through in situ accumulation of all-trans-retinoic acid.
    The Prostate, 1995, Volume: 27, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Imidazoles; Immunoblotting; Immunohistochemistry; Keratins; Male; Neoplasm Transplantation; Organ Size; Prostate; Prostatic Neoplasms; Random Allocation; Rats; Rats, Inbred F344; Tretinoin; Tumor Cells, Cultured; Vimentin

1995
Liarozole fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid.
    Biochemical pharmacology, 1994, Feb-11, Volume: 47, Issue:4

    Topics: Androgen Antagonists; Animals; Antineoplastic Agents; Cricetinae; Imidazoles; Male; Mesocricetus; Microsomes, Liver; Tretinoin

1994
Retinoid induction of CRABP II mRNA in human dermal fibroblasts: use as a retinoid bioassay.
    The Journal of investigative dermatology, 1996, Volume: 106, Issue:3

    Topics: Biological Assay; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Fibroblasts; Humans; Imidazoles; Receptors, Retinoic Acid; Retinaldehyde; Retinoids; RNA, Messenger; Skin; Tretinoin

1996
Analysis of the oxidative catabolism of retinoic acid in rat Dunning R3327G prostate tumors.
    The Prostate, 1996, Volume: 29, Issue:1

    Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Female; Imidazoles; Kinetics; Liver; Male; NADP; Oxidation-Reduction; Prostatic Neoplasms; Rats; Rats, Wistar; Tretinoin

1996
Liarozole inhibits human epidermal retinoic acid 4-hydroxylase activity and differentially augments human skin responses to retinoic acid and retinol in vivo.
    The Journal of investigative dermatology, 1996, Volume: 107, Issue:2

    Topics: Androgen Antagonists; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Synergism; Epidermis; Humans; Imidazoles; Retinoic Acid 4-Hydroxylase; Skin; Tretinoin; Vitamin A

1996
Liarozole amplifies retinoid-induced apoptosis in human prostate cancer cells.
    Anti-cancer drugs, 1996, Volume: 7, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; beta Carotene; Blotting, Northern; Cell Division; DNA Fragmentation; Drug Synergism; Genes, bcl-2; Humans; Imidazoles; Male; Prostatic Neoplasms; Retinoids; RNA, Messenger; Thymosin; Tretinoin; Tumor Cells, Cultured

1996
Liarozole potentiates the all-trans-retinoic acid-induced structural remodelling in human breast carcinoma MCF-7 cells in vitro.
    European journal of cell biology, 1996, Volume: 71, Issue:1

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma; Cell Adhesion Molecules; Cell Division; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Imidazoles; Neoplasm Proteins; Tretinoin

1996
Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis.
    Endocrinology, 1997, Volume: 138, Issue:4

    Topics: Animals; Gene Expression Regulation; Imidazoles; Male; Mice; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoic Acid Receptor gamma; Retinoid X Receptors; RNA, Messenger; Spermatogenesis; Testis; Transcription Factors; Tretinoin

1997
Induction of the oxidative catabolism of retinoid acid in MCF-7 cells.
    British journal of cancer, 1997, Volume: 75, Issue:8

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cytosol; Female; Humans; Imidazoles; Keratolytic Agents; Oxidation-Reduction; Reproducibility of Results; Retinoids; Retinol-Binding Proteins; Tretinoin; Tumor Cells, Cultured

1997
The antiproliferative activity of all-trans-retinoic acid catabolites and isomers is differentially modulated by liarozole-fumarate in MCF-7 human breast cancer cells.
    British journal of cancer, 1998, Volume: 77, Issue:8

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Chromatography, High Pressure Liquid; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Imidazoles; Stereoisomerism; Tretinoin; Tumor Cells, Cultured

1998
Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1998, Volume: 9, Issue:8

    Topics: Blotting, Northern; Blotting, Western; Breast Neoplasms; Chromatography; Colonic Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Female; Humans; Hydroxylation; Imidazoles; Microsomes; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase; Retinoic Acid Receptor alpha; Retinoic Acid Receptor gamma; Substrate Specificity; Transfection; Tretinoin; Tumor Cells, Cultured

1998
Synthesis of LIAZAL, a retinoic acid metabolism blocking agent (RAMBA) with potential clinical applications in oncology and dermatology.
    Bioorganic & medicinal chemistry letters, 1998, Feb-03, Volume: 8, Issue:3

    Topics: Animals; Antineoplastic Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dermatologic Agents; Enzyme Inhibitors; Humans; Imidazoles; Magnetic Resonance Spectroscopy; Molecular Structure; Rats; Retinoic Acid 4-Hydroxylase; Tretinoin

1998
Altered metabolism of all-trans-retinoic acid in liposome-encapsulated form.
    Cancer letters, 1998, Dec-25, Volume: 134, Issue:2

    Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Carriers; Enzyme Inhibitors; Imidazoles; Liposomes; Male; Microsomes, Liver; Rats; Teratocarcinoma; Testicular Neoplasms; Tretinoin; Tumor Cells, Cultured

1998
Embryonal carcinoma cell lines stably transfected with mRARbeta2-lacZ: sensitive system for measuring levels of active retinoids.
    Experimental cell research, 1999, Aug-01, Volume: 250, Issue:2

    Topics: Animals; Carcinoma, Embryonal; Chick Embryo; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gene Expression Regulation, Developmental; Genes, Reporter; Imidazoles; Isomerism; Ketoconazole; Limb Buds; Mesoderm; Mice; Promoter Regions, Genetic; Receptors, Retinoic Acid; Retinoids; Time Factors; Transcriptional Activation; Transfection; Tretinoin; Tumor Cells, Cultured

1999
Are we ready to use surrogate end points and surrogate tissues to evaluate response to chemopreventive and therapeutic intervention?
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Biomarkers; Biopsy; Clinical Trials as Topic; Health Services Research; Humans; Imidazoles; Mouth; Mucous Membrane; Neoplasms; Treatment Outcome; Tretinoin

2000
Liarozole markedly increases all trans-retinoic acid toxicity in mouse limb bud cell cultures: a model to explain the potency of the aromatic retinoid (E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl)-1-propenyl] benzoic acid.
    Toxicology and applied pharmacology, 2002, Feb-01, Volume: 178, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzoates; Cells, Cultured; Chondrogenesis; Chromatography, High Pressure Liquid; Drug Synergism; Enzyme Inhibitors; Imidazoles; Limb Buds; Mice; Retinoids; Structure-Activity Relationship; Tretinoin

2002
Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.
    British journal of cancer, 2002, Feb-12, Volume: 86, Issue:4

    Topics: Animals; Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Cell Division; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Mixed Function Oxygenases; Retinoic Acid 4-Hydroxylase; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Tretinoin; Tumor Cells, Cultured

2002
Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles.
    Bioorganic & medicinal chemistry, 2006, Jun-01, Volume: 14, Issue:11

    Topics: Benzofurans; Binding Sites; Cell Line, Tumor; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Humans; Imidazoles; Ligands; Models, Molecular; Molecular Structure; Protein Conformation; Retinoic Acid 4-Hydroxylase; Stereoisomerism; Structure-Activity Relationship; Tretinoin; Triazoles; Tumor Cells, Cultured

2006
Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways.
    Developmental biology, 2009, Feb-15, Volume: 326, Issue:2

    Topics: Animals; Cell Differentiation; Cells, Cultured; Doublecortin Domain Proteins; Doublecortin Protein; Enzyme Inhibitors; Fibroblast Growth Factors; Hedgehog Proteins; Imidazoles; Microtubule-Associated Proteins; Neurons; Neuropeptides; Prosencephalon; Pyrroles; Rats; Rats, Wistar; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Signal Transduction; Stem Cells; Tretinoin

2009
Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis.
    Archives of dermatological research, 2009, Volume: 301, Issue:7

    Topics: Acyltransferases; Alcohol Oxidoreductases; Androgen Antagonists; Benzothiazoles; Biomarkers; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Epidermis; Feedback, Physiological; Gene Expression Regulation, Enzymologic; Heparin-binding EGF-like Growth Factor; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Keratin-2; Keratin-4; Keratinocytes; Receptors, Retinoic Acid; Retinal Dehydrogenase; Retinoic Acid 4-Hydroxylase; Tretinoin; Triazoles; Vitamin A

2009
Leiomyoma fibrosis inhibited by liarozole, a retinoic acid metabolic blocking agent.
    Fertility and sterility, 2012, Volume: 98, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Cell Proliferation; Dose-Response Relationship, Drug; Extracellular Matrix; Extracellular Matrix Proteins; Female; Humans; Imidazoles; Leiomyoma; Tretinoin; Tumor Cells, Cultured; Uterine Neoplasms

2012
Accelerated degradation of retinoic acid by activated microglia.
    Journal of neuroimmunology, 2013, Mar-15, Volume: 256, Issue:1-2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Cells, Cultured; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Nitric Oxide; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Messenger; Time Factors; Tretinoin; Tumor Necrosis Factor-alpha

2013
The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis.
    Immunity, 2014, Apr-17, Volume: 40, Issue:4

    Topics: Adenosine Triphosphate; Animals; Cell Degranulation; Cytochrome P-450 Enzyme System; Dermatitis; Fibroblasts; Imidazoles; Immunity, Innate; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Microbiota; Receptors, Purinergic P2X7; Retinoic Acid 4-Hydroxylase; Skin; Toll-Like Receptor 2; Tretinoin

2014