lewis-x-antigen and cyclopamine

lewis-x-antigen has been researched along with cyclopamine* in 1 studies

Other Studies

1 other study(ies) available for lewis-x-antigen and cyclopamine

Article	Year
Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+ cell compartment and the in vitro tumorigenic capability of neuroblastoma cells. Cancer letters, 2011, Nov-28, Volume: 310, Issue:2 Sonic hedgehog (Hh) developmental pathway deregulation has been proven to play an essential role in several malignancies as neuroblastoma. We found that Hh signaling is active in neuroblastoma, as most pathway components, including GLI1, were expressed in cell lines and tumor samples. Furthermore, SHH ligand expression was found in cell lines and tumors, and GLI1 up-regulation was achieved in response to SHH treatment, suggesting an autocrine mechanism of aberrant activation. A decrease of proliferation and tumorigenic potential, as well as increased apoptosis and a dramatic decrease in the percentage of CD15+ cell population were produced upon Hh inhibition by cyclopamine. Topics: AC133 Antigen; Antigens, CD; Apoptosis; Biomarkers, Tumor; Cell Growth Processes; Cell Line, Tumor; Female; Fucosyltransferases; Gene Expression Regulation, Neoplastic; Glycoproteins; Hedgehog Proteins; Humans; Lewis X Antigen; Male; Neoplastic Stem Cells; Neuroblastoma; Peptides; Signal Transduction; Transcription Factors; Veratrum Alkaloids; Zinc Finger Protein GLI1	2011

Article

Year

Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+ cell compartment and the in vitro tumorigenic capability of neuroblastoma cells.

Cancer letters, 2011, Nov-28, Volume: 310, Issue:2

Sonic hedgehog (Hh) developmental pathway deregulation has been proven to play an essential role in several malignancies as neuroblastoma. We found that Hh signaling is active in neuroblastoma, as most pathway components, including GLI1, were expressed in cell lines and tumor samples. Furthermore, SHH ligand expression was found in cell lines and tumors, and GLI1 up-regulation was achieved in response to SHH treatment, suggesting an autocrine mechanism of aberrant activation. A decrease of proliferation and tumorigenic potential, as well as increased apoptosis and a dramatic decrease in the percentage of CD15+ cell population were produced upon Hh inhibition by cyclopamine.

Topics: AC133 Antigen; Antigens, CD; Apoptosis; Biomarkers, Tumor; Cell Growth Processes; Cell Line, Tumor; Female; Fucosyltransferases; Gene Expression Regulation, Neoplastic; Glycoproteins; Hedgehog Proteins; Humans; Lewis X Antigen; Male; Neoplastic Stem Cells; Neuroblastoma; Peptides; Signal Transduction; Transcription Factors; Veratrum Alkaloids; Zinc Finger Protein GLI1

2011