levorphanol and glaucine

Twenty-four inpatients affected by chronic cough completed a single-dose double-blind cross-over study of placebo, glaucine 30 mg and dextromethorphan 30 mg. The study was carried out using a balanced incomplete block design, each patient receiving two of the three experimental treatments. Objective evaluation of cough was ensured by means of a writing cough recorder. Coughs after dextromethorphan and glaucine were fewer than coughs after placebo: however only glaucine was significantly different from placebo in reducing coughs. Treatments were well tolerated: clinical results included a reduction in pulse rate after both dextromethorphan and glaucine , and a large number of patients reporting side effects after dextromethorphan administration.

Topics: Adult; Aged; Antitussive Agents; Aporphines; Clinical Trials as Topic; Cough; Dextromethorphan; Double-Blind Method; Female; Headache; Humans; Levorphanol; Male; Middle Aged; Pulse; Random Allocation; Sleep Wake Disorders; Vision Disorders