levorphanol and dimemorfan

Ion-selective electrodes (ISEs) responsive to the antitussives dextromethorphan and dimemorfan were constructed by the fixation of an ion-exchanger, ammonium tetraphenylborate, on a Millipore membrane by means of a plasma-polymerization technique. The electrodes showed a Nernstian response over the range of 10(-5)-10(-2) M dextromethorphan and dimemorphan, and the working pH range was 5-7. The interference from common cations such as Na+, K+ and Ca2+ was negligible but some organic cations interfered weakly. The electrodes were applied successfully for the determination of the drugs in pharmaceutical preparations.

Topics: Dextromethorphan; Electrodes; Levorphanol; Membrane Potentials; Morphinans

Topics: Animals; Antineoplastic Agents; Antitussive Agents; Carcinoma, Ehrlich Tumor; Dextromethorphan; Female; Levorphanol; Lipid Metabolism; Mice; Mice, Inbred Strains; Morphinans; Neoplasms, Experimental; Sarcoma 180