levorphanol has been researched along with chlornaltrexamine* in 2 studies
2 other study(ies) available for levorphanol and chlornaltrexamine
| Article | Year |
|---|---|
Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties.
Chlornaltrexamine (CNA) produces ultralong-lasting (3--6 days) narcotic antagonism in mice and persistent stereospecific binding to rat-brain homogenate. Protection studies in mice suggest that CNA mediates its narcotic antagonist effects by interacting with the same receptors that are occupied by naloxone. A single icv dose of CNA also has been found to inhibit the development of physical dependence in mice for at least 3 days. These studies suggest that CNA exerts its sustained effects by selective covalent association with opioid receptors. Topics: Alkylating Agents; Analgesics; Animals; Humans; In Vitro Techniques; Male; Mice; Molecular Conformation; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Rats; Receptors, Opioid; Time Factors | 1979 |
6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty.
Topics: Alkylating Agents; Analgesia; Binding, Competitive; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Receptors, Opioid | 1978 |