Page last updated: 2024-09-04

levofloxacin and warfarin

levofloxacin has been researched along with warfarin in 35 studies

Compound Research Comparison

Studies (levofloxacin)	Trials (levofloxacin)	Recent Studies (post-2010) (levofloxacin)	Studies (warfarin)	Trials (warfarin)	Recent Studies (post-2010) (warfarin)
4,346	581	2,209	36,573	2,143	14,728

Protein Interaction Comparison

Protein	Taxonomy	levofloxacin (IC50)	warfarin (IC50)
Vitamin K epoxide reductase complex subunit 1	Homo sapiens (human)		0.0088

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.86)	18.2507
2000's	21 (60.00)	29.6817
2010's	12 (34.29)	24.3611
2020's	1 (2.86)	2.80

Authors

Authors	Studies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Gozalbes, R; Pineda-Lucena, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS	1
Fowler, C; Liao, S; Nayak, RK; Palmer, M	1
Locke, C; Ravnan, SL	1
Cinetto, L; Gheno, G	1
Fugate, SE; Jones, CB	1
Burrows, MM; Enlow, AM; Greenwood, MC; Kilpatrick, DM; Lower, DL; Yamreudeewong, W	1
Fugit, RV; Glasheen, JJ; Prochazka, AV	2
Anderson, HG; McCall, KL; Scott, JC	1
Bell, CM; Kopp, A; Mamdami, MM; Stroud, LF	1
Cole, J; Mathews, S; Ryono, RA	1
Glasheen, JJ; Prochazka, AV	2
Ismail, HM; Smalligan, RD; Vadlamudi, RS	1
Ahmed, A; Fay, WP; Kaus, CA; Stephens, JC	1
Carroll, DG; Carroll, DN	1
Gracia García, B; Jodar Masanés, R; Leiva Badosa, E; Mercadal Orfila, G; Perayre Badía, M; Reynaldo Martínez, C	1
Abe, Y; Ikegami, Y; Nemoto, C; Shimada, J; Tase, C; Tsukada, Y	1
Bomgaars, LR; Kim, S; Moffett, BS	1
Chen, H; Li, H; Lin, J; Liu, X; Xu, S; Xu, Y; Yuan, Z	1

Reviews

2 review(s) available for levofloxacin and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Interactions between warfarin and three commonly prescribed fluoroquinolones. The Annals of pharmacotherapy, 2008, Volume: 42, Issue:5 Topics: Aza Compounds; Ciprofloxacin; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Fluoroquinolones; Humans; International Normalized Ratio; Levofloxacin; Moxifloxacin; Ofloxacin; Quinolines; Warfarin	2008

Trials

3 trial(s) available for levofloxacin and warfarin

Article	Year
Absence of an effect of levofloxacin on warfarin pharmacokinetics and anticoagulation in male volunteers. Journal of clinical pharmacology, 1996, Volume: 36, Issue:11 Topics: Administration, Oral; Adult; Anti-Infective Agents; Anticoagulants; Blood Coagulation; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Humans; Levofloxacin; Liver; Male; Ofloxacin; Warfarin	1996
Impact of preemptive warfarin dose reduction on anticoagulation after initiation of trimethoprim-sulfamethoxazole or levofloxacin. Journal of thrombosis and thrombolysis, 2008, Volume: 26, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Anticoagulants; Blood Coagulation; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Female; Humans; International Normalized Ratio; Levofloxacin; Male; Middle Aged; Ofloxacin; Trimethoprim, Sulfamethoxazole Drug Combination; Warfarin	2008
Readmissions for warfarin-related bleeding in pediatric patients after hospital discharge. Pediatric blood & cancer, 2013, Volume: 60, Issue:9 Topics: Adolescent; Anti-Bacterial Agents; Anticoagulants; Asian; Cardiac Surgical Procedures; Child; Child, Preschool; Citalopram; Female; Hospital Information Systems; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Patient Readmission; Postoperative Hemorrhage; Risk Factors; Selective Serotonin Reuptake Inhibitors; Time Factors; Warfarin	2013

Other Studies

30 other study(ies) available for levofloxacin and warfarin

Article	Year
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
The antitubercular activity of various nitro(triazole/imidazole)-based compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles	2017
Levofloxacin and warfarin interaction. Pharmacotherapy, 2001, Volume: 21, Issue:7 Topics: Aged; Anti-Infective Agents; Anticoagulants; Blood Coagulation; Drug Interactions; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Warfarin	2001
Levofloxacin-warfarin interaction. European journal of clinical pharmacology, 2001, Volume: 57, Issue:5 Topics: Administration, Oral; Aged; Anti-Infective Agents; Anticoagulants; Drug Interactions; Female; Follow-Up Studies; Hemorrhage; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Warfarin	2001
Levofloxacin and warfarin interaction. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Anticoagulants; Drug Administration Schedule; Drug Synergism; Female; Humans; International Normalized Ratio; Levofloxacin; Male; Middle Aged; Ofloxacin; Prothrombin Time; Warfarin	2002
Effect of levofloxacin coadministration on the international normalized ratios during warfarin therapy. Pharmacotherapy, 2003, Volume: 23, Issue:3 Topics: Aged; Aged, 80 and over; Drug Interactions; Drug Therapy, Combination; Female; Hospitals, Veterans; Humans; International Normalized Ratio; Levofloxacin; Male; Middle Aged; Ofloxacin; Warfarin	2003
Effect of levofloxacin coadministration on the international normalized ratios during warfarin therapy--a comment. Pharmacotherapy, 2003, Volume: 23, Issue:8 Topics: Anticoagulants; Drug Interactions; Drug Therapy, Combination; Humans; International Normalized Ratio; Levofloxacin; Ofloxacin; Warfarin	2003
Retrospective evaluation of a possible interaction between warfarin and levofloxacin. Pharmacotherapy, 2005, Volume: 25, Issue:1 Topics: Aged; Body Temperature; Data Collection; Drug Administration Schedule; Drug Interactions; Drug Prescriptions; Drug Therapy, Combination; Felodipine; Female; Humans; International Normalized Ratio; Levofloxacin; Male; Medical Records; Middle Aged; Ofloxacin; Outpatients; Randomized Controlled Trials as Topic; Retrospective Studies; Time Factors; Treatment Outcome; Warfarin	2005
The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens. Journal of general internal medicine, 2005, Volume: 20, Issue:7 Topics: Administration, Oral; Aged; Anti-Infective Agents; Anticoagulants; Azithromycin; Cohort Studies; Drug Interactions; Female; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Platelet Aggregation Inhibitors; Prazosin; Retrospective Studies; Trimethoprim, Sulfamethoxazole Drug Combination; Warfarin	2005
The safety of levofloxacin in elderly patients on warfarin. The American journal of medicine, 2005, Volume: 118, Issue:12 Topics: Acute Disease; Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticoagulants; Case-Control Studies; Drug Interactions; Female; Hemorrhage; Humans; Levofloxacin; Male; Odds Ratio; Ofloxacin; Ontario; Thrombosis; Warfarin	2005
Anticoagulation-related outcomes in patients receiving warfarin after starting levofloxacin or gatifloxacin. Pharmacotherapy, 2006, Volume: 26, Issue:10 Topics: Aged; Anticoagulants; Databases as Topic; Drug Monitoring; Drug Therapy, Combination; Female; Fluoroquinolones; Gatifloxacin; Hospitals, Veterans; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Retrospective Studies; Risk Assessment; Risk Factors; Treatment Outcome; United States; Warfarin	2006
The safety of levofloxacin in patients on warfarin. The American journal of medicine, 2007, Volume: 120, Issue:4 Topics: Anti-Bacterial Agents; Anticoagulants; Drug Interactions; Hemorrhage; Humans; International Normalized Ratio; Levofloxacin; Ofloxacin; Thrombosis; Warfarin	2007
Interaction between warfarin and levofloxacin: case series. Southern medical journal, 2007, Volume: 100, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticoagulants; Drug Interactions; Female; Hemorrhage; Humans; Levofloxacin; Male; Ofloxacin; Pericardial Effusion; Retroperitoneal Space; Warfarin	2007
Further evidence of a clinically significant levofloxacin-warfarin interaction. Southern medical journal, 2008, Volume: 101, Issue:6 Topics: Anti-Bacterial Agents; Anticoagulants; Drug Interactions; Hemorrhage; Humans; International Normalized Ratio; Levofloxacin; Ofloxacin; Risk Factors; Warfarin	2008
Retrospective assessment of potential interaction between levofloxacin and warfarin. Pharmacy world & science : PWS, 2009, Volume: 31, Issue:2 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticoagulants; Biomarkers; Drug Interactions; Female; Humans; Inpatients; International Normalized Ratio; Levofloxacin; Male; Middle Aged; Ofloxacin; Retrospective Studies; Time Factors; Warfarin	2009
Acute renal failure caused by severe coagulopathy induced by the interaction between warfarin potassium and levofloxacin: a case report. Journal of anesthesia, 2012, Volume: 26, Issue:6 Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Anticoagulants; Blood Coagulation Disorders; Cardiomyopathy, Dilated; Drug Interactions; Hematuria; Humans; International Normalized Ratio; Levofloxacin; Male; Ofloxacin; Shock; Urinary Tract Infections; Warfarin	2012
Light-Triggered Fluorescence Self-Reporting Nitric Oxide Release from Coumarin Analogues for Accelerating Wound Healing and Synergistic Antimicrobial Applications. Journal of medicinal chemistry, 2022, 01-13, Volume: 65, Issue:1 Topics: Animals; Anti-Bacterial Agents; Biofilms; Cell Movement; Cell Proliferation; Coumarins; Drug Synergism; Female; Fluorescence; Human Umbilical Vein Endothelial Cells; Humans; Levofloxacin; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Donors; Wound Healing	2022