Page last updated: 2024-09-04

levofloxacin and nalidixic acid

levofloxacin has been researched along with nalidixic acid in 54 studies

Compound Research Comparison

Studies (levofloxacin)	Trials (levofloxacin)	Recent Studies (post-2010) (levofloxacin)	Studies (nalidixic acid)	Trials (nalidixic acid)	Recent Studies (post-2010) (nalidixic acid)
4,346	581	2,209	3,246	87	340

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.85)	18.2507
2000's	29 (53.70)	29.6817
2010's	21 (38.89)	24.3611
2020's	3 (5.56)	2.80

Authors

Authors	Studies
Chen, S; Cui, S; McDermott, PF; Meng, J; Paulsen, I; White, DG; Zhao, S	1
Choi, TY; Pai, H; Seo, MR	1
Catalan, A; de la Campa, AG; Dominguez, L; Escudero, JA; Gonzalez-Zorn, B; Lopez, G; Moreno, MA; Rivero, E; San Millan, A	1
Barth, AL; Castanheira, M; Gales, AC; Nicoletti, AG; Pereira, AS; Pignatari, AC	1
Campos, J; García-Cobos, S; Pérez-Vázquez, M; Román, F	1
Aubry, A; Cambau, E; Jarlier, V; Matrat, S; Petrella, S; Sougakoff, W	1
Courvalin, P; Galimand, M; Périchon, B	1
Arakawa, Y; Kato, H; Kimura, K; Konda, T; Shibata, N; Shibayama, K; Suzuki, S; Wachino, J; Yamane, K	1
Andres, P; Centrón, D; Galas, M; Guerriero, L; Petroni, A; Quiroga, C; Quiroga, MP; Soler Bistué, AJ; Tokumoto, M; Tolmasky, ME; Vargas, LJ; Zorreguieta, A	1
Iredell, JR; Partridge, SR; Zong, Z	1
Arakawa, Y; Chen, L; Chen, ZL; Deng, YT; Gao, JH; Liu, JH; Zeng, ZL	1
Carmeli, Y; Chmelnitsky, I; Navon-Venezia, S; Strahilevitz, J	1
Cattoir, V; Nordmann, P; Poirel, L	1
Hiramatsu, K; Kikuchi, K; Ohtsuka, M; Ono, Y; Sasaki, T; Shimizu, K; Takahashi, N	2
Bremont, S; Charavay, F; Courvalin, P; Goarant, C; Le Hello, S; O'Connor, O; Page, S; Vernel-Pauillac, F	1
Chen, Z; Deng, Y; Huang, L; Liu, J; Lü, D; Ma, J; Wang, M; Wang, X; Xu, X; Zeng, Z; Zhang, Y	1
Baptista, BC; Correia, JD; da Fonseca, JD; Martínez-Martínez, L; Pomba, C	1
Guo, Q; Hooper, DC; Wang, M; Wang, X; Wu, S; Xu, X; Ye, X	1
Bartalesi, F; Bartoloni, A; Gamboa, H; Gotuzzo, E; Mantella, A; Pallecchi, L; Riccobono, E; Rossolini, GM; Sennati, S	1
Accogli, M; Caprioli, A; Carattoli, A; Cerquetti, M; Fortini, D; García-Fernández, A; Giufrè, M; Graziani, C; Luzzi, I	1
Caddick, JM; Gunell, M; Hakanen, AJ; Huovinen, P; Jalava, J; Kotilainen, P; Lilly, AJ; Piddock, LJ; Siitonen, A; Webber, MA	1
Albertí, S; Bengoechea, JA; Doménech-Sánchez, A; Llobet, E; Martínez-Martínez, L; Padilla, E	1
Ahmed, S; Calderwood, SB; Faruque, AS; Hooper, DC; Jacoby, GA; Khan, WA; Kim, HB; LaRocque, RC; Park, CH; Qadri, F; Salam, MA; Wang, M	1
Bartalesi, F; Bartoloni, A; Gotuzzo, E; Mantella, A; Pallecchi, L; Riccobono, E; Rossolini, GM; Sennati, S; Trigoso, C	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Hakanen, AJ; Huovinen, P; Kotilainen, P; Lehtopolku, M; Nakari, UM; Siitonen, A	1
Blango, MG; Mulvey, MA	1
Ahn, JH; Bae, IK; Lee, JE; Lee, JJ; Lee, SH; Park, I; Park, KS; Sun, HI; Woo, GJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Bialek, S; Chevalier, J; Davin, A; Lavigne, JP; Leflon-Guibout, V; Marcon, E; Moreau, R; Nicolas-Chanoine, MH; Pagès, JM	1
Gozalbes, R; Pineda-Lucena, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Ashenden, S; Bender, A; Cokol, M; Karakoc, I; Kuru, N; Mason, DJ; Meral, S; Stott, I; Weinstein, ZB	1
Blaskovich, MAT; Pham, TDM; Ziora, ZM	1
Maskell, JP; Sefton, AM; Williams, JD	1
Aguilar, L; Garcia-Mendez, E; Jiménez De Anta, MT; Marco, F; Mensa, J; Ruiz, J; Sierra, JM; Vila, J	1
Aracil, B; Campos, J; Cantón, R; Pérez-Vázquez, M; Román, F	1
Chiu, SS; Chow, KH; Ho, AY; Ho, PL; Lai, EL; Lau, YL; Mak, GC; Tsang, KW	1
Ho, PL; Lau, SK; Mak, GC; Tse, CW; Wong, SS	1
Bilker, WB; Fishman, NO; Lautenbach, E; Mao, X; Metlay, JP; Nachamkin, I; Tolomeo, P	1
Cambau, E; Cattoir, V; Denamur, E; Lascols, C; Legrand, P; Lesprit, P; Soussy, CJ	1
Ryzhko, IV; Trishina, AV; Verkina, LM	1
Cho, JK; Kim, JH; Kim, KS	1
Ardanuy, C; Calatayud, L; de la Campa, AG; Garmendia, J; Liñares, J; Marti, S; Puig, C; Tirado-Vélez, JM; Tubau, F	1
Åhman, J; Kahlmeter, G; Matuschek, E; Petersen, A; Sjölund-Karlsson, M; Skov, R; Stegger, M; Torpdahl, M	1
Hidalgo, AA; Millanao, AR; Mora, AY; Mora, GC; Saavedra, CP; Valenzuela, LM; Villagra, NA	1
Dogan, A; Donmez, F	1
Ebrahimzadeh, F; Gholami, S; Jafari-Sales, A; Rostami, A; Zadeh, FA	1
Gunardi, WD; Moehario, LH; Nainggolan, IM; Nathania, I; Nusatia, ACM; Tjoa, E; Yasmon, A	1

Reviews

3 review(s) available for levofloxacin and nalidixic acid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Quinolone antibiotics. MedChemComm, 2019, Oct-01, Volume: 10, Issue:10 Topics:	2019
Globally Vibrio cholera antibiotics resistance to RNA and DNA effective antibiotics: A systematic review and meta-analysis. Microbial pathogenesis, 2022, Volume: 172 Topics: Anti-Bacterial Agents; Cephalothin; Cholera; Cholera Toxin; Ciprofloxacin; Drug Resistance, Bacterial; Furazolidone; Gatifloxacin; Humans; Levofloxacin; Microbial Sensitivity Tests; Nalidixic Acid; Nitrofurantoin; Norfloxacin; Novobiocin; Rifampin; Vibrio cholerae; Virulence Factors	2022

Other Studies

51 other study(ies) available for levofloxacin and nalidixic acid

Article	Year
Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Animals; Anti-Infective Agents; DNA Topoisomerases; Drug Resistance, Bacterial; Fluoroquinolones; Gene Targeting; Genes, Bacterial; Mutation; Salmonella Infections, Animal; Salmonella typhimurium	2007
Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; Cephalosporins; Drug Resistance, Multiple, Bacterial; Escherichia coli; Humans; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Plasmids; Quinolones	2007
First characterization of fluoroquinolone resistance in Streptococcus suis. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Amino Acid Sequence; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Bacterial; Female; Fluoroquinolones; Genes, Bacterial; Humans; Male; Molecular Sequence Data; Point Mutation; RNA, Ribosomal, 16S; Sequence Alignment; Streptococcus suis	2007
First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: Anti-Bacterial Agents; Ciprofloxacin; Conjugation, Genetic; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Integrons; Latin America; Molecular Sequence Data; Plasmids	2007
Fluoroquinolone resistance in Haemophilus influenzae is associated with hypermutability. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: Anti-Infective Agents; Drug Resistance, Bacterial; Fluoroquinolones; Genes, Bacterial; Haemophilus Infections; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Mutation	2007
Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:5 Topics: Anti-Infective Agents; DNA; DNA Gyrase; DNA, Superhelical; Enzyme Inhibitors; Mycobacterium leprae; Quinolones; Topoisomerase II Inhibitors	2007
Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7 Topics: Amino Acid Motifs; Amino Acid Sequence; Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; Conjugation, Genetic; Conserved Sequence; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Escherichia coli; Escherichia coli Proteins; Fluoroquinolones; Genes, rRNA; Methylation; Methyltransferases; Microbial Sensitivity Tests; Molecular Sequence Data; Norfloxacin; Plasmids; Sequence Analysis, DNA; Sequence Homology, Amino Acid	2007
New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chitosan; Conjugation, Genetic; DNA, Bacterial; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Fluoroquinolones; Humans; Malates; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Transformation, Bacterial; Uncoupling Agents	2007
Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12 Topics: Alleles; Amino Acid Sequence; Argentina; Bacterial Proteins; Base Sequence; beta-Lactamases; Cross Infection; DNA Transposable Elements; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Integrons; Microbial Sensitivity Tests; Molecular Sequence Data; Polymerase Chain Reaction; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid	2007
RmtC 16S rRNA methyltransferase in Australia. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2 Topics: Aminoglycosides; Anti-Bacterial Agents; Australia; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Drug Resistance, Bacterial; Genes, rRNA; Humans; Methyltransferases; Microbial Sensitivity Tests; Proteus Infections; Proteus mirabilis; RNA, Ribosomal, 16S	2008
Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8 Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Fluoroquinolones; Methyltransferases; Plasmids; RNA, Ribosomal, 16S; Swine; Swine Diseases	2008
Plasmid-mediated qnrB2 and carbapenemase gene bla(KPC-2) carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8 Topics: Anti-Infective Agents; Bacterial Proteins; beta-Lactamases; Carbapenems; Ciprofloxacin; Drug Resistance, Bacterial; Enterobacter cloacae; Genes, Bacterial; Microbial Sensitivity Tests; Plasmids; Quinolones	2008
Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10 Topics: Aged; Base Sequence; DNA Primers; DNA, Bacterial; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Female; Fluoroquinolones; France; Genes, Bacterial; Humans; Models, Genetic; Molecular Sequence Data; Plasmids	2008
Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10 Topics: Alleles; Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; Chromosomes, Bacterial; DNA Primers; DNA, Bacterial; Drug Resistance, Bacterial; Fluoroquinolones; Genes, Bacterial; Gram-Negative Bacterial Infections; Humans; Molecular Sequence Data; Sequence Homology, Amino Acid; Stenotrophomonas maltophilia	2008
Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:11 Topics: Amino Acid Substitution; Base Sequence; DNA Gyrase; DNA Mutational Analysis; DNA Primers; DNA Probes; DNA Topoisomerase IV; DNA, Bacterial; Drug Resistance, Bacterial; Fluoroquinolones; Genes, Bacterial; Humans; Nucleic Acid Denaturation; Point Mutation; Polymerase Chain Reaction; Streptococcus pneumoniae; Thermodynamics	2008
High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2 Topics: Acetyltransferases; Adolescent; Adult; Aged; Animals; Animals, Domestic; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Cambodia; Cephalosporins; China; Conjugation, Genetic; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Escherichia coli Proteins; Female; Humans; Male; Mali; Microbial Sensitivity Tests; Middle Aged; Nasal Cavity; Plasmids; Quinolones; Young Adult	2009
Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1 Topics: Animals; Anti-Bacterial Agents; Dogs; Drug Resistance, Bacterial; Escherichia coli; Genes, Bacterial; Humans; Plasmids; Virulence	2009
New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5 Topics: Amino Acid Sequence; Anti-Infective Agents; Bacterial Proteins; Base Sequence; Conjugation, Genetic; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Polymerase Chain Reaction; Proteus Infections; Proteus mirabilis; Quinolones; Sequence Analysis, DNA	2009
High prevalence of qnr genes in commensal enterobacteria from healthy children in Peru and Bolivia. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6 Topics: Bacterial Proteins; Base Sequence; Bolivia; Child; Child, Preschool; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Humans; Infant; Klebsiella pneumoniae; Molecular Sequence Data; Peru; Plasmids; Polymerase Chain Reaction; Quinolones	2009
Emergence of quinolone-resistant Bordetella pertussis in Japan. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Anti-Bacterial Agents; Bordetella pertussis; Child; DNA Gyrase; Fluoroquinolones; Humans; Japan; Microbial Sensitivity Tests; Mutation; Nalidixic Acid; Quinolones	2009
First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Drug Resistance, Bacterial; Escherichia coli; Genes, Bacterial; Microbial Sensitivity Tests; Plasmids; Poultry; Poultry Diseases; Quinolones; Salmonella enterica	2009
Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9 Topics: Bacterial Proteins; Drug Resistance, Bacterial; Electroporation; Genotype; Microbial Sensitivity Tests; Plasmids; Polymerase Chain Reaction; Quinolones; Salmonella enterica	2009
Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bronchoalveolar Lavage Fluid; Culture Media; Defensins; DNA, Bacterial; Drug Resistance, Bacterial; Genotype; Humans; Klebsiella Infections; Klebsiella pneumoniae; Lipopolysaccharides; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Phenotype; Plasmids; Polymyxin B; Polysaccharides; Repressor Proteins; RNA, Bacterial	2010
Transferable quinolone resistance in Vibrio cholerae. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2 Topics: Anti-Bacterial Agents; Bacterial Proteins; Chromosomes, Bacterial; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Transposable Elements; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; Mutation; Polymerase Chain Reaction; Quinolones; Vibrio cholerae	2010
Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2 Topics: Anti-Bacterial Agents; DNA Transposable Elements; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Genotype; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Polymerase Chain Reaction; Quinolones	2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3 Topics: Anti-Bacterial Agents; Campylobacter coli; Campylobacter Infections; Campylobacter jejuni; Carbapenems; Drug Resistance, Multiple, Bacterial; Erythromycin; Feces; Finland; Humans; Macrolides; Microbial Sensitivity Tests; Minocycline; Tigecycline	2010
Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5 Topics: Animals; Anti-Bacterial Agents; Biofilms; Cell Membrane Permeability; Cells, Cultured; Drug Resistance, Bacterial; Endosomes; Escherichia coli; Escherichia coli Infections; Female; Humans; Mice; Mice, Inbred CBA; Microbial Sensitivity Tests; Recurrence; Urinary Bladder; Urinary Tract Infections; Urothelium	2010
Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7 Topics: Animals; Bacterial Proteins; Chickens; Citrobacter; Citrobacter freundii; Escherichia coli; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Polymerase Chain Reaction; Quinolones; Swine	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:10 Topics: Animals; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Bacterial Proteins; beta-Lactams; Biological Transport; Caenorhabditis elegans; Drug Resistance, Bacterial; Ertapenem; Klebsiella pneumoniae; Reverse Transcriptase Polymerase Chain Reaction; Virulence	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Prediction of Antibiotic Interactions Using Descriptors Derived from Molecular Structure. Journal of medicinal chemistry, 2017, 05-11, Volume: 60, Issue:9 Topics: Anti-Bacterial Agents; Drug Interactions; Molecular Structure	2017
Selection of resistant variants of respiratory pathogens by quinolones. International journal of antimicrobial agents, 1999, Volume: 12, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Haemophilus influenzae; Humans; Levofloxacin; Microbial Sensitivity Tests; Moraxella catarrhalis; Nalidixic Acid; Ofloxacin; Pneumonia, Bacterial; Streptococcus pneumoniae	1999
In vitro activity of gemifloxacin against clinical isolates of Neisseria gonorrhoeae with and without mutations in the gyrA gene. International journal of antimicrobial agents, 2003, Volume: 22, Issue:1 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Genes, Bacterial; Gonorrhea; Humans; In Vitro Techniques; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Nalidixic Acid; Naphthyridines; Neisseria gonorrhoeae; Ofloxacin; Quinolines	2003
Laboratory detection of Haemophilus influenzae with decreased susceptibility to nalidixic acid, ciprofloxacin, levofloxacin, and moxifloxacin due to GyrA and ParC mutations. Journal of clinical microbiology, 2004, Volume: 42, Issue:3 Topics: Aza Compounds; Base Sequence; Ciprofloxacin; DNA Gyrase; DNA Primers; DNA Topoisomerase IV; Fluoroquinolones; Haemophilus Infections; Haemophilus influenzae; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Nalidixic Acid; Ofloxacin; Polymerase Chain Reaction; Quinolines	2004
Decreased levofloxacin susceptibility in Haemophilus influenzae in children, Hong Kong. Emerging infectious diseases, 2004, Volume: 10, Issue:11 Topics: Anti-Bacterial Agents; Carrier State; Child; Child, Preschool; Drug Resistance, Bacterial; Haemophilus influenzae; Hong Kong; Humans; Infant; Levofloxacin; Nalidixic Acid; Nasopharynx; Ofloxacin	2004
Reduced levofloxacin susceptibility and tetracycline resistance in a clinical isolate of Haemophilus quentini identified by 16S rRNA sequencing. Journal of clinical microbiology, 2005, Volume: 43, Issue:10 Topics: Anti-Bacterial Agents; Bacteremia; Bacterial Typing Techniques; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Female; Haemophilus; Haemophilus Infections; Humans; Infant, Newborn; Levofloxacin; Nalidixic Acid; Ofloxacin; Phenotype; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Tetracycline Resistance	2005
Phenotypic and genotypic characterization of fecal Escherichia coli isolates with decreased susceptibility to fluoroquinolones: results from a large hospital-based surveillance initiative. The Journal of infectious diseases, 2006, Jul-01, Volume: 194, Issue:1 Topics: Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Electrophoresis, Gel, Pulsed-Field; Escherichia coli; Escherichia coli Infections; Feces; Fluoroquinolones; Genotype; Hospitals; Humans; Levofloxacin; Microbial Sensitivity Tests; Mutation; Nalidixic Acid; Ofloxacin; Phenotype; Population Surveillance; Solvents	2006
In vivo selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but susceptibility to nalidixic acid. The Journal of antimicrobial chemotherapy, 2006, Volume: 58, Issue:5 Topics: Aged; Anti-Bacterial Agents; Bacteremia; DNA Topoisomerases; Drug Resistance; Escherichia coli; Escherichia coli Infections; Humans; Levofloxacin; Male; Nalidixic Acid; Ofloxacin	2006
[Lack of levofloxacin and moxyfloxacin efficacy in experimental plague of albino mice infected with nalidixic acid resistant pathogen (Nal(r))]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2010, Volume: 55, Issue:11-12 Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Drug Resistance, Bacterial; Lethal Dose 50; Levofloxacin; Mice; Models, Animal; Nalidixic Acid; Ofloxacin; Plague; Virulence; Yersinia pestis	2010
Prevalence and characterization of plasmid-mediated quinolone resistance genes in Salmonella isolated from poultry in Korea. Avian pathology : journal of the W.V.P.A, 2013, Volume: 42, Issue:3 Topics: Animals; Blotting, Southern; Ciprofloxacin; DNA Primers; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Escherichia coli; Gene Transfer, Horizontal; Levofloxacin; Microbial Sensitivity Tests; Nalidixic Acid; Plasmids; Polymerase Chain Reaction; Poultry; Poultry Diseases; Quinolones; Republic of Korea; Salmonella; Salmonella Infections, Animal	2013
Molecular characterization of fluoroquinolone resistance in nontypeable Haemophilus influenzae clinical isolates. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Typing Techniques; Base Sequence; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA, Bacterial; Drug Resistance, Bacterial; Female; Fluoroquinolones; Genetic Variation; Haemophilus Infections; Haemophilus influenzae; Humans; Levofloxacin; Male; Microbial Sensitivity Tests; Middle Aged; Multilocus Sequence Typing; Nalidixic Acid; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Infections; Sequence Analysis, DNA	2015
Development of a Pefloxacin Disk Diffusion Method for Detection of Fluoroquinolone-Resistant Salmonella enterica. Journal of clinical microbiology, 2015, Volume: 53, Issue:11 Topics: Anti-Bacterial Agents; Bacteremia; Base Sequence; Ciprofloxacin; Disk Diffusion Antimicrobial Tests; DNA Gyrase; DNA Topoisomerase IV; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Humans; Levofloxacin; Nalidixic Acid; Ofloxacin; Pefloxacin; Salmonella enterica; Salmonella Infections; Sequence Analysis, DNA	2015
Cysteine auxotrophy drives reduced susceptibility to quinolones and paraquat by inducing the expression of efflux-pump systems and detoxifying enzymes in S. Typhimurium. Biochemical and biophysical research communications, 2019, 07-23, Volume: 515, Issue:2 Topics: Anti-Bacterial Agents; Bacterial Proteins; Ciprofloxacin; Cysteine; Drug Resistance, Multiple, Bacterial; Gene Deletion; Gene Expression; Genes, Bacterial; Humans; Levofloxacin; Membrane Transport Proteins; Mutation; Nalidixic Acid; Paraquat; Quinolones; Reactive Oxygen Species; Salmonella typhimurium; Sulfur	2019
Investigation of the effects of three different generations of fluoroquinolone derivatives on antioxidant and immunotoxic enzyme levels in different rat tissues. Drug and chemical toxicology, 2022, Volume: 45, Issue:6 Topics: Adenosine Deaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Ciprofloxacin; COVID-19; Creatinine; Fluoroquinolones; Glucose; Glutathione; Glutathione Peroxidase; Levofloxacin; Lipid Peroxidation; Malondialdehyde; Moxifloxacin; Nalidixic Acid; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; SARS-CoV-2; Superoxide Dismutase; Triglycerides	2022
Hotspots sequences of gyrA, gyrB, parC, and parE genes encoded for fluoroquinolones resistance from local Salmonella Typhi strains in Jakarta. BMC microbiology, 2022, 10-18, Volume: 22, Issue:1 Topics: Amino Acids; Anti-Bacterial Agents; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Nalidixic Acid; Quinolones; Salmonella; Salmonella enterica; Salmonella typhi; Typhoid Fever	2022