Compounds > levofloxacin
Page last updated: 2024-09-04

levofloxacin and mibefradil

levofloxacin has been researched along with mibefradil in 6 studies

Compound Research Comparison

Studies
(levofloxacin)		Trials
(levofloxacin)		Recent Studies (post-2010)
(levofloxacin)		Studies
(mibefradil)		Trials
(mibefradil)		Recent Studies (post-2010) (mibefradil)
4,3465812,20966769143

Protein Interaction Comparison

ProteinTaxonomylevofloxacin (IC50)mibefradil (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.156
Voltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)1.0476
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.333
Voltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)0.4122
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)0.5
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
ATP-dependent translocase ABCB1Homo sapiens (human)1.58
Cytochrome P450 3A4Homo sapiens (human)0.2575
Cytochrome P450 2D6Homo sapiens (human)0.063
Cytochrome P450 2C9 Homo sapiens (human)2.14
Sodium channel protein type 4 subunit alphaRattus norvegicus (Norway rat)0.5
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.34
ATP-dependent translocase ABCB1Mus musculus (house mouse)7.4
Sodium channel protein type 1 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 4 subunit alphaHomo sapiens (human)0.98
Cytochrome P450 2J2Homo sapiens (human)2.14
Voltage-dependent L-type calcium channel subunit beta-3Rattus norvegicus (Norway rat)1
Voltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)0.878
Sodium channel protein type 7 subunit alphaHomo sapiens (human)0.98
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.333
Voltage-dependent N-type calcium channel subunit alpha-1BRattus norvegicus (Norway rat)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.4543
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.333
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.2795
Sodium channel protein type 5 subunit alphaHomo sapiens (human)0.74
Sodium channel protein type 9 subunit alphaHomo sapiens (human)0.74
Sodium channel protein type 2 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 3 subunit alphaHomo sapiens (human)0.98
Voltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)0.4187
Sodium channel protein type 11 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 8 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 10 subunit alphaHomo sapiens (human)0.98

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Keserü, GM1
Nagashima, R; Nishikawa, T; Tobita, M1
Lombardo, F; Obach, RS; Waters, NJ1
Jia, L; Sun, H1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1

Other Studies

6 other study(ies) available for levofloxacin and mibefradil

ArticleYear
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010