Compounds > levofloxacin
Page last updated: 2024-09-04

levofloxacin and methapyrilene

levofloxacin has been researched along with methapyrilene in 7 studies

Compound Research Comparison

Studies
(levofloxacin)		Trials
(levofloxacin)		Recent Studies (post-2010)
(levofloxacin)		Studies
(methapyrilene)		Trials
(methapyrilene)		Recent Studies (post-2010) (methapyrilene)
4,3465812,209206325

Protein Interaction Comparison

ProteinTaxonomylevofloxacin (IC50)methapyrilene (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.744
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.391
Muscarinic acetylcholine receptor M2Homo sapiens (human)1.665
Muscarinic acetylcholine receptor M5Homo sapiens (human)3.265
Alpha-2A adrenergic receptorHomo sapiens (human)1.165
Cytochrome P450 2D6Homo sapiens (human)2.7564
Muscarinic acetylcholine receptor M1Homo sapiens (human)4.773
Alpha-2B adrenergic receptorHomo sapiens (human)3.318
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.391
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.628
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.744
Sodium-dependent serotonin transporterHomo sapiens (human)0.2
Histamine H1 receptorHomo sapiens (human)0.016
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.843
5-hydroxytryptamine receptor 6Homo sapiens (human)3.091
Sodium-dependent dopamine transporter Homo sapiens (human)2.757

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Ekins, S; Williams, AJ; Xu, JJ1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1

Other Studies

7 other study(ies) available for levofloxacin and methapyrilene

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012