Page last updated: 2024-09-04

levofloxacin and ketoconazole

levofloxacin has been researched along with ketoconazole in 18 studies

Compound Research Comparison

Studies (levofloxacin)	Trials (levofloxacin)	Recent Studies (post-2010) (levofloxacin)	Studies (ketoconazole)	Trials (ketoconazole)	Recent Studies (post-2010) (ketoconazole)
4,346	581	2,209	6,202	706	1,269
4,346	581	2,209	149	0	120

Protein Interaction Comparison

Protein	Taxonomy	ketoconazole (IC50)
Solute carrier family 22 member 1	Homo sapiens (human)	2.6
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	Homo sapiens (human)	0.34
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	Mus musculus (house mouse)	0.36
Bile salt export pump	Homo sapiens (human)	3.44
Steroid 17-alpha-hydroxylase/17,20 lyase	Homo sapiens (human)	1.5811
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	6.7
ATP-dependent translocase ABCB1	Homo sapiens (human)	4.6771
Cytochrome P450 3A4	Homo sapiens (human)	0.2303
Steroid 21-hydroxylase	Homo sapiens (human)	6.655
Cytochrome P450 2C8	Homo sapiens (human)	0.06
Aromatase	Homo sapiens (human)	1.4111
Steroid 17-alpha-hydroxylase/17,20 lyase	Rattus norvegicus (Norway rat)	2.0802
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	5.425
Cholesterol side-chain cleavage enzyme, mitochondrial	Rattus norvegicus (Norway rat)	3.32
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	1.067
Cytochrome P450 2A2	Rattus norvegicus (Norway rat)	0.456
Cytochrome P450 11B1, mitochondrial	Bos taurus (cattle)	0.38
Cytochrome P450 11B1, mitochondrial	Homo sapiens (human)	0.4519
Translocator protein	Rattus norvegicus (Norway rat)	3.76
Cytochrome P450 7A1	Rattus norvegicus (Norway rat)	1.2975
Cytochrome P450 11B2, mitochondrial	Homo sapiens (human)	0.5179
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	3.8
Thromboxane-A synthase	Homo sapiens (human)	2.165
Gonadotropin-releasing hormone receptor	Rattus norvegicus (Norway rat)	2
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.531
Type-1 angiotensin II receptor	Oryctolagus cuniculus (rabbit)	0.0078
Cytochrome P450 4F2	Homo sapiens (human)	1.6
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	Homo sapiens (human)	0.4144
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	1.9036
Lanosterol 14-alpha demethylase	Homo sapiens (human)	0.19
Cytochrome P450 7A1	Mus musculus (house mouse)	1.2975
Lanosterol 14-alpha demethylase	Rattus norvegicus (Norway rat)	0.083
Epoxide hydrolase 1	Homo sapiens (human)	0.04
Cytochrome P450 2D6	Homo sapiens (human)	2.774
Cytochrome P450 3A5	Homo sapiens (human)	0.2535
Bifunctional epoxide hydrolase 2	Homo sapiens (human)	0.04
Sterol 14-alpha demethylase	Trypanosoma cruzi strain CL Brener	0.014

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (33.33)	29.6817
2010's	12 (66.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Keserü, GM	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Jia, L; Sun, H	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Aytemir, MD; Ozçelik, B	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS	1
Gao, F; Huang, G; Xiao, J	1

Reviews

2 review(s) available for levofloxacin and ketoconazole

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Current scenario of tetrazole hybrids for antibacterial activity. European journal of medicinal chemistry, 2019, Dec-15, Volume: 184 Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Tetrazoles	2019

Other Studies

16 other study(ies) available for levofloxacin and ketoconazole

Article	Year
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities. European journal of medicinal chemistry, 2010, Volume: 45, Issue:9 Topics: Animals; Anti-Infective Agents; Antiviral Agents; Bacteria; Cell Line; Chlorocebus aethiops; Drug Evaluation, Preclinical; Fungi; Herpesvirus 1, Human; Mannich Bases; Microbial Sensitivity Tests; Parainfluenza Virus 3, Human; Pyrones; Spectrum Analysis; Vero Cells	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
The antitubercular activity of various nitro(triazole/imidazole)-based compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles	2017