Compounds > levofloxacin
Page last updated: 2024-09-04

levofloxacin and gentamicin sulfate

levofloxacin has been researched along with gentamicin sulfate in 61 studies

Compound Research Comparison

Studies
(levofloxacin)		Trials
(levofloxacin)		Recent Studies (post-2010)
(levofloxacin)		Studies
(gentamicin sulfate)		Trials
(gentamicin sulfate)		Recent Studies (post-2010) (gentamicin sulfate)
4,3465812,209384292

Protein Interaction Comparison

ProteinTaxonomylevofloxacin (IC50)gentamicin sulfate (IC50)
30S ribosomal protein S6Escherichia coli K-120.028
30S ribosomal protein S7Escherichia coli K-120.028
50S ribosomal protein L15Escherichia coli K-120.028
50S ribosomal protein L10Escherichia coli K-120.028
50S ribosomal protein L11Escherichia coli K-120.028
50S ribosomal protein L7/L12Escherichia coli K-120.028
50S ribosomal protein L19Escherichia coli K-120.028
50S ribosomal protein L1Escherichia coli K-120.028
50S ribosomal protein L20Escherichia coli K-120.028
50S ribosomal protein L27Escherichia coli K-120.028
50S ribosomal protein L28Escherichia coli K-120.028
50S ribosomal protein L29Escherichia coli K-120.028
50S ribosomal protein L31Escherichia coli K-120.028
50S ribosomal protein L31 type BEscherichia coli K-120.028
50S ribosomal protein L32Escherichia coli K-120.028
50S ribosomal protein L33Escherichia coli K-120.028
50S ribosomal protein L34Escherichia coli K-120.028
50S ribosomal protein L35Escherichia coli K-120.028
50S ribosomal protein L36Escherichia coli K-120.028
30S ribosomal protein S10Escherichia coli K-120.028
30S ribosomal protein S11Escherichia coli K-120.028
30S ribosomal protein S12Escherichia coli K-120.028
30S ribosomal protein S13Escherichia coli K-120.028
30S ribosomal protein S16Escherichia coli K-120.028
30S ribosomal protein S18Escherichia coli K-120.028
30S ribosomal protein S19Escherichia coli K-120.028
30S ribosomal protein S20Escherichia coli K-120.028
30S ribosomal protein S2Escherichia coli K-120.028
30S ribosomal protein S3Escherichia coli K-120.028
30S ribosomal protein S4Escherichia coli K-120.028
30S ribosomal protein S5Escherichia coli K-120.028
30S ribosomal protein S8Escherichia coli K-120.028
30S ribosomal protein S9Escherichia coli K-120.028
50S ribosomal protein L13Escherichia coli K-120.028
50S ribosomal protein L14Escherichia coli K-120.028
50S ribosomal protein L16Escherichia coli K-120.028
50S ribosomal protein L23Escherichia coli K-120.028
30S ribosomal protein S15Escherichia coli K-120.028
50S ribosomal protein L17Escherichia coli K-120.028
50S ribosomal protein L21Escherichia coli K-120.028
50S ribosomal protein L30Escherichia coli K-120.028
50S ribosomal protein L6Escherichia coli K-120.028
30S ribosomal protein S14Escherichia coli K-120.028
30S ribosomal protein S17Escherichia coli K-120.028
30S ribosomal protein S1Escherichia coli K-120.028
50S ribosomal protein L18Escherichia coli K-120.028
50S ribosomal protein L2Escherichia coli K-120.028
50S ribosomal protein L3Escherichia coli K-120.028
50S ribosomal protein L24Escherichia coli K-120.028
50S ribosomal protein L4Escherichia coli K-120.028
50S ribosomal protein L22Escherichia coli K-120.028
50S ribosomal protein L5Escherichia coli K-120.028
30S ribosomal protein S21Escherichia coli K-120.028
50S ribosomal protein L25Escherichia coli K-120.028
50S ribosomal protein L36 2Escherichia coli K-120.028

Research

Studies (61)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's38 (62.30)29.6817
2010's23 (37.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Clark, NC; Donlan, RM; Dumas, N; Jensen, B; Kohlerschmidt, D; Limberger, RJ; McDougal, LK; Musser, KA; Patel, JB; Shin, DH; Thompson, J; Weigel, LM; Zhu, W1
Barth, AL; Castanheira, M; Gales, AC; Nicoletti, AG; Pereira, AS; Pignatari, AC1
Bonomo, RA; Endimiani, A; Hujer, AM; Hujer, KM; Luzzaro, F; Mantengoli, E; Migliavacca, R; Pagani, L; Rossolini, GM; Toniolo, A1
Hovde, LB; Kroeger, LA; Mitropoulos, IF; Rotschafer, JC; Schafer, J1
Liu, Y; Shi, W; Wang, M; Wu, S; Xu, X; Ye, X; Zhang, Y1
Chen, M; Guo, P; Sun, H; Wang, H; Xu, Y; Yang, Q; Zhu, Y1
Clark, NC; Hageman, J; McDonald, LC; McDougal, LK; Patel, JB; Zhu, W1
Calvo, J; Martínez-Martínez, L; Salas, C1
Baudry, PJ; DeCorby, M; Hoban, DJ; Johnson, J; Karlowsky, JA; Lagacé-Wiens, P; Laing, N; McCracken, M; Mulvey, MR; Nichol, KA; Tailor, F; Vashisht, R; Walkty, A; Weshnoweski, B; Wierzbowski, A; Zhanel, GG1
Arakawa, Y; Suzuki, S; Wachino, J; Yamane, K1
Baudry, PJ; DeCorby, M; Hoban, DJ; Mataseje, L; Mulvey, MR; Nichol, K; Zhanel, GG1
Danese, P; DeVito, J; Franceschi, F; Lawrence, L; Sutcliffe, J1
Petersen, JM; Urich, SK1
Bethel, CR; Bonomo, RA; Carias, LL; Endimiani, A; Fox, WR; Hall, GS; Hujer, AM; Hujer, KM; Hutton, RA; Jacobs, MR; Jenkins, SG; Paterson, DL; Perez, F; Rice, LB; Tenover, FC1
Lombardo, F; Obach, RS; Waters, NJ1
Benton, BM; Draghi, DC; Krause, KM; Pillar, C; Sahm, DF; Thornsberry, C1
Benton, BM; Debabov, DV; Difuntorum, S; Krause, KM; Renelli, M; Wu, TX1
Carmeli, Y; Chmelnitsky, I; Navon-Venezia, S; Strahilevitz, J1
Craft, DW; Hachmeister, L; Hong, SG; Kim, SY; Moland, ES; Sayed, SD; Thomson, KS1
Cauda, R; D'Inzeo, T; De Pascale, G; Fadda, G; Fiori, B; Leone, F; Rossi, M; Sali, M; Sanguinetti, M; Spanu, T; Trecarichi, EM; Tumbarello, M1
Bratu, S; Georgescu, C; Landman, D; Martin, DA; Quale, J1
Amsler, KM; Bush, K; Davies, TA; Jacobs, MR; Shang, W1
Biek, D; Ge, Y; Sahm, DF; Talbot, GH1
Cattoir, V; Nordmann, P; Poirel, L1
Chen, H; Chen, M; Wang, H; Yang, H; Yang, Q1
Amicosante, G; De Luca, F; Luzzaro, F; Migliavacca, R; Mugnaioli, C; Pagani, L; Perilli, M; Pini, B; Pollini, S; Rossolini, GM; Spalla, M; Toniolo, A1
Gentry, DR; Gwynn, MN; Holmes, DJ; McCloskey, L; Rittenhouse, SF; Scangarella, N; Shawar, R1
Bennett, JW; Herrera, ML; Jorgensen, JH; Lewis, JS; Wickes, BW1
Chen, Z; Deng, Y; Huang, L; Liu, J; Lü, D; Ma, J; Wang, M; Wang, X; Xu, X; Zeng, Z; Zhang, Y1
Baptista, BC; Correia, JD; da Fonseca, JD; Martínez-Martínez, L; Pomba, C1
Cui, L; Hiramatsu, K; Neoh, HM; Shoji, M1
Bell, JM; Biedenbach, DJ; Jones, RN; Sader, HS; Turnidge, JD1
Guo, Q; Hooper, DC; Wang, M; Wang, X; Wu, S; Xu, X; Ye, X1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Hafkin, B; Hoban, DJ; Kaplan, N; Karlowsky, JA; Zhanel, GG1
Chen, H; Chen, M; Liu, Y; Ma, Y; Nichols, WW; Sun, W; Wang, H; Zhang, J; Zhao, C1
Han, S; Hwang, JK; Lee, K; Rukayadi, Y; Yong, D1
Arhin, FF; Draghi, DC; Moeck, G; Parr, TR; Pillar, CM; Sahm, DF1
Albertí, S; Bengoechea, JA; Doménech-Sánchez, A; Llobet, E; Martínez-Martínez, L; Padilla, E1
Ahmed, S; Calderwood, SB; Faruque, AS; Hooper, DC; Jacoby, GA; Khan, WA; Kim, HB; LaRocque, RC; Park, CH; Qadri, F; Salam, MA; Wang, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Dunman, PM; Hood, MI; Jacobs, AC; Sayood, K; Skaar, EP1
Aquino, EE; León, CF; Otero, DM; Robledo, IE; Santana, JL; Santé, MI; Vázquez, GJ1
Hakanen, AJ; Huovinen, P; Kotilainen, P; Lehtopolku, M; Nakari, UM; Siitonen, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Chang, SC; Chen, YC; Hsia, KC; Li, SY; Liao, MH; Lin, YC; Sheng, WH1
Blango, MG; Mulvey, MA1
Carmeli, Y; Chmelnitsky, I; Goren, MG; Navon-Venezia, S1
Carmeli, Y; Chmelnitsky, I; Goren, MG; Leavitt, A; Navon-Venezia, S; Ofek, I1
Janechek, MJ; Jones, RN; Mendes, RE; Moet, GJ1
Barber, M; Eberly, LE; Feeney, LA; Miller, GH; Summers, A; Wortmann, G; Zapor, MJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Bulens, SN; Fosheim, GE; Limbago, BM; McDougal, LK; Nicholson, A; Patel, JB; Shearer, JE; Summers, AO1
Aytemir, MD; Ozçelik, B1
Bavari, S; Bowlin, TL; Butler, MM; Moir, DT; Panchal, RG; Peet, NP; Shinabarger, DL; Williams, JD1
Clark, M; Doolittle, J; Giddings, MC; Khatun, J; Ramkissoon, K; Secrest, A; Su, HC; Wolfgang, MC1
Hamprecht, A; Higgins, PG; Schneiders, T; Seifert, H1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chopra, S; Kushwaha, P; Modukuri, RK; Pasupuleti, M; Rao, KB; Sashidhara, KV; Shukla, PK; Singh, P; Soni, I1
Aung, TT; Beuerman, RW; Caroline, V; Chew, YS; Koh, JJ; Lakshminarayanan, R; Li, J; Lin, H; Liu, S; Pang, LM; Tan, AL; Tan, DT; Verma, C1
Du, XL; Huo, HR; Li, C; Li, J; Li, JT; Li, X; Ma, H; Sui, F; Sui, YP; Wang, WH; Wang, ZJ; Xin, JJ; Zhan, HD; Zhou, HY1

Trials

1 trial(s) available for levofloxacin and gentamicin sulfate

ArticleYear
In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Anti-Bacterial Agents; Cephalosporins; Enterobacteriaceae; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Skin Diseases, Bacterial; Staphylococcus

2008

Other Studies

60 other study(ies) available for levofloxacin and gentamicin sulfate

ArticleYear
High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1

    Topics: Acetamides; Aminoglycosides; Biofilms; Catheters, Indwelling; Chloramphenicol; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; Female; Fluoroquinolones; Humans; Linezolid; Macrolides; Microbial Sensitivity Tests; Micrococcus; Middle Aged; Morganella morganii; Oxazolidinones; Penicillins; Pseudomonas aeruginosa; Rifampin; Staphylococcus aureus; Tetracyclines; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Catheterization; Vancomycin; Vancomycin Resistance

2007
First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Conjugation, Genetic; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Integrons; Latin America; Molecular Sequence Data; Plasmids

2007
Spread in an Italian hospital of a clonal Acinetobacter baumannii strain producing the TEM-92 extended-spectrum beta-lactamase.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6

    Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Cross Infection; Humans; Italy; Microbial Sensitivity Tests

2007
Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9

    Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Ceftazidime; Colistin; Colony Count, Microbial; Drug Combinations; Drug Resistance, Multiple, Bacterial; Microbial Sensitivity Tests

2007
Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11

    Topics: Anti-Infective Agents; Base Sequence; Ciprofloxacin; DNA, Bacterial; Drug Resistance, Bacterial; Enterobacter cloacae; Enterobacteriaceae; Gene Expression Regulation, Bacterial; Genes, Bacterial; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid

2007
Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11

    Topics: Acinetobacter; Acinetobacter Infections; Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; beta-Lactams; Blotting, Southern; Carbapenems; China; Chloramphenicol; Colistin; Cross Infection; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Hospitals; Humans; Imipenem; Integrons; Microbial Sensitivity Tests; Molecular Epidemiology; Molecular Sequence Data; Rifampin; Sequence Analysis, DNA

2007
Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Carbon-Oxygen Ligases; Conjugation, Genetic; DNA Transposable Elements; DNA, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus faecalis; Humans; Michigan; Microbial Sensitivity Tests; Plasmids; Polymerase Chain Reaction; Restriction Mapping; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance

2008
Activity of Tigecycline against Coryneform Bacteria of Clinical Interest and Listeria monocytogenes.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4

    Topics: Actinomycetales; Anti-Bacterial Agents; Humans; Listeria monocytogenes; Microbial Sensitivity Tests; Minocycline; Tigecycline

2008
Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; beta-Lactamases; Canada; Drug Resistance, Bacterial; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Male; Microbial Sensitivity Tests; Middle Aged; Population Surveillance

2008
Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4

    Topics: Anti-Bacterial Agents; Conjugation, Genetic; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Fluoroquinolones; Hospitals; Humans; Japan; Microbial Sensitivity Tests; Plasmids; Prevalence

2008
Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Bacterial Proteins; beta-Lactamases; Canada; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Fluoroquinolones; Gentamicins; Humans; Intensive Care Units; Microbial Sensitivity Tests

2008
In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Anti-Infective Agents; Bacteria; Community-Acquired Infections; Cross Infection; Enterococcus; Humans; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones; Respiratory System; Staphylococcus; Staphylococcus aureus; Streptococcus; Streptococcus pneumoniae

2008
In vitro susceptibility of isolates of Francisella tularensis types A and B from North America.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6

    Topics: Anti-Bacterial Agents; Francisella tularensis; Humans; Microbial Sensitivity Tests; North America; Tularemia

2008
Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Aged; Bacterial Proteins; Base Sequence; beta-Lactamases; DNA Primers; DNA, Bacterial; Drug Resistance, Bacterial; Genes, Bacterial; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Microbial Sensitivity Tests; Molecular Epidemiology; Plasmids; Quinolones; United States

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Lipoglycopeptides; Microbial Sensitivity Tests; Prospective Studies; Staphylococcus aureus; Streptococcus; Streptococcus pneumoniae; United States

2008
In vitro activity of telavancin against resistant gram-positive bacteria.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; In Vitro Techniques; Lipoglycopeptides; Methicillin Resistance; Microbial Sensitivity Tests; Staphylococcus; Streptococcus

2008
Plasmid-mediated qnrB2 and carbapenemase gene bla(KPC-2) carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8

    Topics: Anti-Infective Agents; Bacterial Proteins; beta-Lactamases; Carbapenems; Ciprofloxacin; Drug Resistance, Bacterial; Enterobacter cloacae; Genes, Bacterial; Microbial Sensitivity Tests; Plasmids; Quinolones

2008
In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8

    Topics: Acinetobacter baumannii; Amikacin; Drug Resistance, Multiple, Bacterial; Drug Synergism; Microbial Sensitivity Tests; Minocycline; Tigecycline

2008
Bloodstream infections caused by extended-spectrum-beta-lactamase- producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; beta-Lactamases; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Multivariate Analysis; Risk Factors; Treatment Failure

2008
Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Bacterial Proteins; beta-Lactamases; Drug Resistance, Bacterial; Endemic Diseases; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; New York City; Sequence Analysis, DNA

2008
In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; United States

2008
Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10

    Topics: Aged; Base Sequence; DNA Primers; DNA, Bacterial; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Female; Fluoroquinolones; France; Genes, Bacterial; Humans; Models, Genetic; Molecular Sequence Data; Plasmids

2008
High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:12

    Topics: Acetyltransferases; Anti-Bacterial Agents; Bacterial Proteins; China; Conjugation, Genetic; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Hospitals, Teaching; Humans; Microbial Sensitivity Tests; Plasmids; Polymerase Chain Reaction; Prevalence; Quinolones

2008
First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:11

    Topics: Base Sequence; beta-Lactam Resistance; beta-Lactamases; Data Collection; DNA Primers; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Genes, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Integrons; Italy; Molecular Epidemiology; Molecular Sequence Data

2008
Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:12

    Topics: Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; Bridged Bicyclo Compounds, Heterocyclic; Diterpenes; Drug Resistance, Bacterial; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Pleuromutilins; Polycyclic Compounds; Sequence Analysis, DNA; Staphylococcus aureus

2008
KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1

    Topics: Anti-Bacterial Agents; beta-Lactamases; Enterobacter cloacae; Female; Humans; Liver Transplantation; Microbial Sensitivity Tests; Middle Aged; Pseudomonas putida; RNA, Ribosomal, 16S

2009
High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2

    Topics: Acetyltransferases; Adolescent; Adult; Aged; Animals; Animals, Domestic; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Cambodia; Cephalosporins; China; Conjugation, Genetic; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Escherichia coli Proteins; Female; Humans; Male; Mali; Microbial Sensitivity Tests; Middle Aged; Nasal Cavity; Plasmids; Quinolones; Young Adult

2009
Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Dogs; Drug Resistance, Bacterial; Escherichia coli; Genes, Bacterial; Humans; Plasmids; Virulence

2009
Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Chromosome Walking; DNA-Binding Proteins; Genetic Engineering; Genome, Bacterial; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Point Mutation; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2009
Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Anti-Bacterial Agents; Asia; Drug Resistance, Bacterial; Europe; Gram-Positive Bacteria; Humans; Latin America; Microbial Sensitivity Tests; North America; Pacific Ocean; Quality Control; Teicoplanin; Vancomycin

2009
New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5

    Topics: Amino Acid Sequence; Anti-Infective Agents; Bacterial Proteins; Base Sequence; Conjugation, Genetic; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Polymerase Chain Reaction; Proteus Infections; Proteus mirabilis; Quinolones; Sequence Analysis, DNA

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8

    Topics: Anti-Bacterial Agents; Benzofurans; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enterobacteriaceae; Enterococcus; Microbial Sensitivity Tests; Moraxella catarrhalis; Pyrones; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pneumoniae

2009
Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9

    Topics: Anti-Bacterial Agents; China; Cities; Drug Resistance, Multiple, Bacterial; Humans; Methicillin-Resistant Staphylococcus aureus; Staphylococcal Infections; Vancomycin; Vancomycin Resistance

2009
In vitro activities of panduratin A against clinical Staphylococcus strains.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10

    Topics: Anti-Bacterial Agents; Chalcones; Humans; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus; Zingiberaceae

2009
Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:11

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus faecium; Glycopeptides; Gram-Positive Bacteria; Humans; Lipoglycopeptides; Microbial Sensitivity Tests; Staphylococcus aureus; Streptococcus

2009
Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Bronchoalveolar Lavage Fluid; Culture Media; Defensins; DNA, Bacterial; Drug Resistance, Bacterial; Genotype; Humans; Klebsiella Infections; Klebsiella pneumoniae; Lipopolysaccharides; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Phenotype; Plasmids; Polymyxin B; Polysaccharides; Repressor Proteins; RNA, Bacterial

2010
Transferable quinolone resistance in Vibrio cholerae.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Chromosomes, Bacterial; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Transposable Elements; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; Mutation; Polymerase Chain Reaction; Quinolones; Vibrio cholerae

2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Bacterial Proteins; Cations, Monovalent; Culture Media; Drug Resistance, Bacterial; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Humans; Microbial Sensitivity Tests; Oligonucleotide Array Sequence Analysis; Proteomics; Sodium Chloride; Virulence Factors

2010
Detection of KPC in Acinetobacter spp. in Puerto Rico.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Acinetobacter; Acinetobacter Infections; Adult; Aged; Aged, 80 and over; beta-Lactam Resistance; beta-Lactamases; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Population Surveillance; Puerto Rico

2010
Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Anti-Bacterial Agents; Campylobacter coli; Campylobacter Infections; Campylobacter jejuni; Carbapenems; Drug Resistance, Multiple, Bacterial; Erythromycin; Feces; Finland; Humans; Macrolides; Microbial Sensitivity Tests; Minocycline; Tigecycline

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5

    Topics: Acinetobacter baumannii; Acinetobacter Infections; Aminoglycosides; beta-Lactamases; Carbapenems; Cephalosporins; DNA Gyrase; Drug Resistance, Bacterial; Drug Resistance, Multiple; Fluoroquinolones; Humans; Taiwan

2010
Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Biofilms; Cell Membrane Permeability; Cells, Cultured; Drug Resistance, Bacterial; Endosomes; Escherichia coli; Escherichia coli Infections; Female; Humans; Mice; Mice, Inbred CBA; Microbial Sensitivity Tests; Recurrence; Urinary Bladder; Urinary Tract Infections; Urothelium

2010
Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6

    Topics: Academic Medical Centers; Bacterial Proteins; Base Sequence; beta-Lactamases; Carbapenems; DNA Primers; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Escherichia coli; Escherichia coli Infections; Humans; In Vitro Techniques; Israel; Microbial Sensitivity Tests; Molecular Epidemiology; Plasmids; Time Factors

2010
Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7

    Topics: Bacterial Proteins; beta-Lactamases; Carbapenems; Drug Resistance, Bacterial; Humans; Israel; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Epidemiology; Phylogeny; Plasmids; Polymerase Chain Reaction

2010
In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6

    Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Humans; In Vitro Techniques; Linezolid; Lipoglycopeptides; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Virginiamycin

2010
In vitro activity of the aminoglycoside antibiotic arbekacin against Acinetobacter baumannii-calcoaceticus isolated from war-wounded patients at Walter Reed Army Medical Center.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7

    Topics: Acinetobacter baumannii; Aminoglycosides; Anti-Bacterial Agents; Carbapenems; Dibekacin; Hospitals, Military; Humans; Microbial Sensitivity Tests; Warfare

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Emergence of resistance among USA300 methicillin-resistant Staphylococcus aureus isolates causing invasive disease in the United States.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Anti-Bacterial Agents; Clindamycin; Doxycycline; Drug Resistance, Multiple; Gentamicins; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mupirocin; Plasmids; Polymerase Chain Reaction; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; United States

2010
A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:9

    Topics: Animals; Anti-Infective Agents; Antiviral Agents; Bacteria; Cell Line; Chlorocebus aethiops; Drug Evaluation, Preclinical; Fungi; Herpesvirus 1, Human; Mannich Bases; Microbial Sensitivity Tests; Parainfluenza Virus 3, Human; Pyrones; Spectrum Analysis; Vero Cells

2010
Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Anti-Bacterial Agents; Gram-Negative Aerobic Bacteria; Gram-Positive Bacteria; Indoles; Microbial Sensitivity Tests

2010
The development of ciprofloxacin resistance in Pseudomonas aeruginosa involves multiple response stages and multiple proteins.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11

    Topics: Anti-Infective Agents; Bacterial Proteins; Ciprofloxacin; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Two-Dimensional; Methylmalonate-Semialdehyde Dehydrogenase (Acylating); Microbial Sensitivity Tests; Pseudomonas aeruginosa; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Succinate-Semialdehyde Dehydrogenase

2010
In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Acinetobacter baumannii; Acinetobacter Infections; Bacterial Proteins; Carbapenems; Drug Resistance, Bacterial; Fatal Outcome; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Reverse Transcriptase Polymerase Chain Reaction

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus.
    ACS medicinal chemistry letters, 2015, Jul-09, Volume: 6, Issue:7

    Topics:

2015
N-Lipidated Peptide Dimers: Effective Antibacterial Agents against Gram-Negative Pathogens through Lipopolysaccharide Permeabilization.
    Journal of medicinal chemistry, 2015, Aug-27, Volume: 58, Issue:16

    Topics: Animals; Anti-Bacterial Agents; Carbapenems; Cell Membrane; Cell Survival; Drug Resistance, Bacterial; Enterobacteriaceae; Fatty Acids; Female; Fibroblasts; Gram-Negative Bacteria; Hemolysis; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Lipopeptides; Lipopolysaccharides; Male; Mice; Microbial Sensitivity Tests; Permeability; Rabbits

2015
Synthesis of biscoumarin and dihydropyran derivatives with promising antitumor and antibacterial activities.
    Bioorganic & medicinal chemistry letters, 2015, Dec-01, Volume: 25, Issue:23

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Carboplatin; Cell Line, Tumor; Cell Proliferation; Coumarins; Crystallography, X-Ray; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Models, Molecular; Pyrans; Staphylococcus aureus

2015