levodopa methyl ester has been researched along with levodopa in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (17.57) | 18.7374 |
| 1990's | 35 (47.30) | 18.2507 |
| 2000's | 12 (16.22) | 29.6817 |
| 2010's | 12 (16.22) | 24.3611 |
| 2020's | 2 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Akiyama, Y; Itoh, A; Koshimura, K; Miwa, S; Ohue, T | 1 |
| Borisenko, SA; Männistö, PT; Törnwall, M; Tuomainen, P; Tuominen, RK | 1 |
| Bramante, L; Quinn, NP; Ruggieri, S; Steiger, MJ; Stocchi, F | 1 |
| Goshima, Y; Kubo, T; Misu, Y; Nakamura, S; Yue, JL | 1 |
| Agnoli, A; Carta, A; Jenner, P; Marsden, CD; Quinn, N; Ruggieri, S; Ryatt, J; Stocchi, F | 1 |
| Goshima, Y; Misu, Y; Nakamura, S; Ohno, K | 1 |
| Meadows, GG; Thrall, BD | 1 |
| Carey, RJ | 1 |
| Goshima, Y; Misu, Y; Nakamura, S | 2 |
| Abdallah, RM; Meadows, GG; Pierson, HF | 1 |
| Kleedorfer, B; Lees, AJ; Stern, GM | 1 |
| Agnoli, A; Carta, A; Marsden, CD; Quinn, NP; Ruggieri, S; Steiger, MJ; Stocchi, F | 1 |
| Borchardt, RT; Hu, M | 1 |
| Agnoli, A; Carta, A; Catarci, M; Ruggieri, S; Stocchi, F | 1 |
| Beart, PM; Cook, CJ; Hashizume, M; Jackson, DM; Tabar, J | 1 |
| Kuhr, WG; May, LJ; Wightman, RM | 1 |
| Chirakal, R; Firnau, G; Garnett, ES | 1 |
| Agnoli, A; Antonini, A; Bragoni, M; Carta, A; Ruggieri, SA; Stocchi, F | 1 |
| Domino, EF; Greenberg, HS; Hood, TW | 1 |
| Chase, TN; Fabbrini, G; Juncos, JL; Mouradian, MM; Serrati, C | 1 |
| Abdallah, RM; Meadows, GG; Starkey, JR | 1 |
| Meadows, GG; Pierson, HF | 2 |
| Barboni, E; D'Erme, M; Fiori, A; Minelli, A; Rosei, MA; Voltattorni, CB | 1 |
| Cooper, DR; Jenner, P; Marrel, C; Marsden, CD; Quinn, N; Testa, B; van de Waterbeemd, H | 1 |
| Abdallah, RM; Desai, PR; Meadows, GG; Pierson, HF | 1 |
| Geffard, M; Goshima, Y; Misu, Y; Nakamura, S; Okamura, H; Yue, JL | 1 |
| Acerbi, D; Mariotti, F; Rondelli, I; Ventura, P | 1 |
| Martí, MJ; Tolosa, ES; Valldeoriola, F | 1 |
| Goshima, Y; Misu, Y; Miyamae, T; Nakamura, S; Yue, JL | 1 |
| Goshima, Y; Misu, Y; Miyamae, T; Okumura, F; Sato, K | 1 |
| Barbato, L; Marsden, CD; O'Connel, MT; Patsalos, PN; Quinn, NP; Ruggieri, S; Stocchi, F | 1 |
| Jenner, P; Marsden, CD; Rose, S | 1 |
| Eller, RV; Gash, DM; Greenamyre, JT; Kurlan, R; Ovadia, A; Zhang, Z | 1 |
| Goshima, Y; Kubo, T; Misu, Y; Miyamae, T; Nakamura, S; Yue, JL | 1 |
| Barbato, L; Bramante, L; Nordera, G; Ruggieri, S; Stocchi, F; Vacca, L | 1 |
| Goshima, Y; Misu, Y; Miyamae, T; Yue, JL | 2 |
| Bonastre, M; Chase, TN; Engber, TM; Marin, C; Papa, S; Tolosa, E | 1 |
| De Souza Silva, MA; Häcker, R; Huston, JP; Mattern, C; Nogueira, PJ; Schwarting, RK | 1 |
| Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T; Ohshima, E; Okumura, Y; Shimizu, M; Sugiyama, Y; Suzuki, F | 1 |
| Domino, EF; Emborg-Knott, ME | 1 |
| Domino, EF; Ni, L | 2 |
| Hayashi, H; Ishii, S; Kagamiyama, H; Okamoto, A | 1 |
| Arai, N; Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T | 1 |
| Goshima, Y; Misu, Y; Miyamae, T; Nishihama, M; Okumura, F | 1 |
| Domino, EF; Ni, L; Zhang, H | 1 |
| Abe, K; Kashihara, K; Manabe, Y; Shiro, Y; Warita, H | 1 |
| Abe, K; Kashihara, K; Manabe, Y; Murakami, T | 1 |
| Acerbi, D; Bettini, R; Caponetti, G; Catellani, PL; Cocconi, D; Colombo, P; Magi, N; Musa, R; Santi, P; Ventura, P | 1 |
| Fenoll, LG; García-Cánovas, F; García-Ruiz, PA; Rodríguez-López, JN; Tudela, J; Varón, R | 1 |
| Geurts, M; Hermans, E; Maloteaux, JM | 1 |
| Froelick, GJ; Kim, DS; Palmiter, RD | 1 |
| Colpaert, F; Domino, EF; Marien, M; Ni, L | 1 |
| Fang, YZ; He, PG; Ning, L; Wang, AF; Wang, J; Zhang, SH; Zhou, Y | 1 |
| Fang, Y; Wang, J | 1 |
| Bernardi, G; Esposito, Z; Martorana, A; Palmieri, MG; Pierantozzi, M; Sancesario, G; Stefani, A | 1 |
| McCairn, KW; Turner, RS | 1 |
| Itoh, S; Oo, C | 1 |
| Cacciatore, I; Conte, C; Cornacchia, C; Minelli, A; Pinnen, F; Prudenzi, E; Taha, E | 1 |
| Dall'Armi, V; Kulisevsky, J; Lamberti, P; Obeso, JA; Stocchi, F; Zappia, M | 1 |
| Bosco, D; Bosco, F; Fava, A; Plastino, M; Rotondo, A | 1 |
| Cai, Y; Liu, Z; Ren, T; Wu, N; Yang, X; Yuan, W | 1 |
| Huang, R; Jiang, W; Li, R; Li, Y; Liang, T | 1 |
| Cai, Y; Liao, M; Liu, Z; Yang, X; Yuan, W; Zheng, R | 1 |
| Chen, Z; Huang, R; Li, R; Liang, T; Lin, X; Zhang, S | 1 |
| Chun, IK; Gwak, HS; Lee, KE; Lee, YH | 1 |
| Chun, IK; Gwak, HS; Kim, KH; Lee, KE; Lee, YH; Rhie, JY; Yoon, IK | 1 |
| Bonastre, M; Cortés, R; Giralt, A; Marin, C; Mengod, G; Obeso, JA; Schapira, AH | 1 |
| Campisi, G; De Caro, V; Giannola, LI; Scaturro, AL | 1 |
| Auger, F; Barthelemy, C; Bezard, E; Bordet, R; Carta, N; Defebvre, L; Demailly, A; Deramecourt, V; Devedjian, JC; Devos, D; Duce, J; Fisichella, M; Kuchcinski, G; Laloux, C; Lannoy, D; Li, Q; Moreau, C; Odou, P; Pioli, E; Rolland, AS | 1 |
| Capelli, C; Charlier, B; Cilia, R; Coglianese, A; Conti, V; D'Urso, A; de Grazia, U; Eleopra, R; Izzo, V; Molteni, L | 1 |
2 review(s) available for levodopa methyl ester and levodopa
| Article | Year |
|---|---|
New and emerging strategies for improving levodopa treatment.
Topics: Animals; Catechol O-Methyltransferase Inhibitors; Delayed-Action Preparations; Dyskinesia, Drug-Induced; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease | 1994 |
Review on the relationship between nicotinic acetylcholine receptors and dopaminergic neurotransmission in the central nervous system--dopa is an endogenous neuroactive substance.
Topics: Animals; Catecholamines; Corpus Striatum; Dihydroxyphenylalanine; In Vitro Techniques; Levodopa; Motor Activity; Nicotine; Rats; Receptors, Nicotinic; Synapses | 1993 |
6 trial(s) available for levodopa methyl ester and levodopa
| Article | Year |
|---|---|
Intravenous boluses and continuous infusions of L-dopa methyl ester in fluctuating patients with Parkinson's disease.
Topics: Aged; Double-Blind Method; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Levodopa; Male; Middle Aged; Motor Skills; Neurologic Examination; Parkinson Disease | 1992 |
Comparison between a fast and a slow release preparation of levodopa and a combination of the two: a clinical and pharmacokinetic study.
Topics: Aged; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease | 1994 |
Fluctuating parkinsonism: a pilot study of single afternoon dose of levodopa methyl ester.
Topics: Administration, Oral; Aged; Analysis of Variance; Antiparkinson Agents; Circadian Rhythm; Delayed-Action Preparations; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Infusions, Parenteral; Levodopa; Male; Middle Aged; Parkinson Disease; Pilot Projects | 1996 |
Influence of layer position on in vitro and in vivo release of levodopa methyl ester and carbidopa from three-layer matrix tablets.
Topics: Administration, Oral; Antiparkinson Agents; Biological Availability; Carbidopa; Chemistry, Pharmaceutical; Cross-Over Studies; Drug Delivery Systems; Humans; Levodopa; Pilot Projects; Tablets, Enteric-Coated | 2002 |
Melevodopa/carbidopa effervescent formulation in the treatment of motor fluctuations in advanced Parkinson's disease.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antiparkinson Agents; Carbidopa; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Intention to Treat Analysis; Levodopa; Male; Middle Aged; Parkinson Disease; Treatment Outcome | 2010 |
Daily motor performance after switching levodopa to melevodopa: an open-label on advanced Parkinson's disease with "delayed-on" and/or"wearing-off".
Topics: Antiparkinson Agents; Drug Substitution; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Psychomotor Performance; Quality of Life | 2011 |
66 other study(ies) available for levodopa methyl ester and levodopa
| Article | Year |
|---|---|
L-dopa administration enhances exocytotic dopamine release in vivo in the rat striatum.
Topics: Animals; Calcium Channel Blockers; Corpus Striatum; Dihydropyridines; Dopamine; Exocytosis; Levodopa; Male; Nomifensine; Potassium; Rats; Rats, Inbred Strains; Sodium Channels; Tetrodotoxin | 1992 |
Effect of nitecapone and clorgyline, given intracerebro-ventricularly on L-dopa metabolism in the rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Carbidopa; Catechols; Cerebral Ventricles; Clorgyline; Corpus Striatum; Dopamine; Homovanillic Acid; Hypothalamus; Injections, Intraventricular; Levodopa; Male; Pentanones; Prolactin; Rats; Rats, Wistar; Thyrotropin | 1992 |
The clinical efficacy of single morning doses of levodopa methyl ester: dispersible Madopar and Sinemet plus in Parkinson disease.
Topics: Benserazide; Carbidopa; Drug Combinations; Humans; Levodopa; Middle Aged; Parkinson Disease | 1992 |
Evidence for L-dopa systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat.
Topics: Animals; Blood Pressure; Calcium; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Heart Rate; Levodopa; Male; Medulla Oblongata; Norepinephrine; Rats; Rats, Inbred Strains | 1992 |
Picomolar concentrations of L-dopa stereoselectively potentiate activities of presynaptic beta-adrenoceptors to facilitate the release of endogenous noradrenaline from rat hypothalamic slices.
Topics: Animals; Cocaine; Electric Stimulation; Hydrazines; Hypothalamus; In Vitro Techniques; Isoproterenol; Levodopa; Male; Norepinephrine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Stereoisomerism | 1991 |
Effect of L-dopa methylester and glutathione depletion on murine B16BL6 melanoma growth in vitro.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Transformation, Neoplastic; Glutathione; Levodopa; Melanoma, Experimental; Methionine Sulfoximine; Mice | 1991 |
Chronic L-dopa treatment in the unilateral 6-OHDA rat: evidence for behavioral sensitization and biochemical tolerance.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Carbidopa; Corpus Striatum; Denervation; Drug Tolerance; Functional Laterality; Homovanillic Acid; Levodopa; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1991 |
L-dihydroxyphenylalanine methyl ester is a potent competitive antagonist of the L-dihydroxyphenylalanine-induced facilitation of the evoked release of endogenous norepinephrine from rat hypothalamic slices.
Topics: Animals; Binding, Competitive; Carbidopa; Cocaine; Hydrazines; Hypothalamus; In Vitro Techniques; Levodopa; Norepinephrine; Propranolol; Rats; Structure-Activity Relationship; Sulpiride | 1991 |
Ascorbate in the treatment of experimental transplanted melanoma.
Topics: Animals; Ascorbic Acid; Dehydroascorbic Acid; Female; Levodopa; Lung Neoplasms; Male; Malondialdehyde; Melanoma, Experimental; Mice; Neoplasm Transplantation | 1991 |
Subcutaneous and sublingual levodopa methyl ester in Parkinson's disease.
Topics: Administration, Sublingual; Antiparkinson Agents; Drug Administration Schedule; Female; Humans; Injections, Subcutaneous; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease | 1991 |
The clinical efficacy of oral levodopa methyl ester solution in reversing afternoon "off" periods in Parkinson's disease.
Topics: Administration, Oral; Aged; Benserazide; Drug Combinations; Humans; Levodopa; Middle Aged; Parkinson Disease | 1991 |
Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2).
Topics: 2,4-Dinitrophenol; Antihypertensive Agents; Biological Transport; Carrier Proteins; Cell Line; Dinitrophenols; Epithelial Cells; Epithelium; Glucose; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa; Intestines; Levodopa; Models, Biological; Phenylalanine; Protein Binding; Temperature | 1990 |
L-dopa methyl ester antagonizes competitively L-dopa-induced facilitation of noradrenaline release from rat hypothalamic slices.
Topics: Animals; Binding, Competitive; Hypothalamus; In Vitro Techniques; Levodopa; Norepinephrine; Phenylalanine; Propranolol; Rats | 1990 |
Jejunal delivery of levodopa methyl ester.
Topics: Humans; Jejunostomy; Levodopa; Male; Middle Aged; Parkinson Disease; Time Factors | 1989 |
The effects on central dopamine function of chronic L-dopa (methyl ester hydrochloride) treatment of mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Body Temperature; Bromocriptine; Dextroamphetamine; Dopamine; Levodopa; Mice; Mice, Inbred Strains; Motor Activity; Receptors, Dopamine; Stereotyped Behavior | 1989 |
Differentiation of dopamine overflow and uptake processes in the extracellular fluid of the rat caudate nucleus with fast-scan in vivo voltammetry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Benztropine; Bupropion; Caudate Nucleus; Dopamine; Electric Stimulation; Electrochemistry; Extracellular Space; Kinetics; Levodopa; Male; Microelectrodes; Neurotransmitter Uptake Inhibitors; Nomifensine; Piperazines; Propiophenones; Rats; Rats, Inbred Strains | 1988 |
High yield synthesis of 6-[18F]fluoro-L-dopa.
Topics: Arsenic; Arsenicals; Boranes; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Fluorides; Fluorine; Isomerism; Isotope Labeling; Levodopa; Radioisotopes; Silanes; Silicon Compounds; Solvents | 1986 |
Continuous dopaminergic stimulation in the management of complicated Parkinson's disease.
Topics: Adult; Ergolines; Female; Humans; Infusions, Intravenous; Levodopa; Lisuride; Male; Middle Aged; Parkinson Disease | 1988 |
Possible treatment of Parkinson's disease with intrathecal medication in the MPTP model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Homovanillic Acid; Infusion Pumps; Injections, Spinal; Levodopa; Parkinson Disease, Secondary; Pyridines; Time Factors | 1988 |
Levodopa methyl ester treatment of Parkinson's disease.
Topics: Administration, Oral; Female; Humans; Infusions, Intravenous; Levodopa; Male; Middle Aged; Parkinson Disease | 1987 |
Interaction between specific dietary factors and experimental chemotherapy of metastatic melanoma.
Topics: Animals; Ascorbic Acid; Diet; Female; Levodopa; Lung Neoplasms; Melanoma; Mice; Mice, Inbred Strains; Phenylalanine; Tyrosine | 1986 |
Modulation of peroxidation in murine melanoma by dietary tyrosine-phenylalanine restriction, levodopa methylester chemotherapy, and sodium ascorbate supplementation.
Topics: Animals; Ascorbic Acid; Diet; Female; Levodopa; Lipid Peroxides; Liver; Malondialdehyde; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenylalanine; Tyrosine | 1985 |
Inhibitors binding to L-aromatic amino acid decarboxylase.
Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Binding Sites; Caffeic Acids; Catechols; Hydroxyindoleacetic Acid; Levodopa; Phenylacetates; Pyridoxal Phosphate; Spectrophotometry; Structure-Activity Relationship | 1982 |
L-Dopa methyl ester--a candidate for chronic systemic delivery of L-Dopa in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Levodopa; Limbic System; Male; Mice; Parkinson Disease; Reserpine | 1984 |
Sodium ascorbate enhancement of carbidopa-levodopa methyl ester antitumor activity against pigmented B16 melanoma.
Topics: Animals; Antineoplastic Agents; Ascorbic Acid; Carbidopa; Cell Line; Diet; Drug Synergism; Drug Therapy, Combination; Female; Injections, Intraperitoneal; Levodopa; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Phenylalanine; Tyrosine | 1983 |
Dietary influence of tyrosine and phenylalanine on the response of B16 melanoma to carbidopa-levodopa methyl ester chemotherapy.
Topics: Animals; Carbidopa; Diet; Drug Evaluation, Preclinical; Female; Levodopa; Melanoma; Mice; Neoplasms, Experimental; Phenylalanine; Tyrosine | 1982 |
Baroreceptor-aortic nerve-mediated release of endogenous L-3,4-dihydroxyphenylalanine and its tonic depressor function in the nucleus tractus solitarii of rats.
Topics: Animals; Aorta; Blood Pressure; Electric Stimulation; Heart Rate; Hypertension; Immunohistochemistry; Levodopa; Male; Medulla Oblongata; Nervous System; Nervous System Physiological Phenomena; Phenylephrine; Potassium; Pressoreceptors; Rats; Rats, Wistar; Reflex; Tyrosine 3-Monooxygenase | 1994 |
Simultaneous determination of levodopa methyl ester, levodopa, 3-O-methyldopa and dopamine in plasma by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Humans; Levodopa; Oxidation-Reduction; Rats; Tyrosine | 1994 |
Endogenously released DOPA is probably relevant to nicotine-induced increases in locomotor activities of rats.
Topics: alpha-Methyltyrosine; Animals; Corpus Striatum; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Injections, Intraventricular; Levodopa; Male; Mecamylamine; Methyltyrosines; Motor Activity; Nerve Fibers; Nicotine; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tyrosine 3-Monooxygenase | 1993 |
L-dopa potentiates presynaptic inhibitory alpha 2-adrenoceptor- but not facilitatory angiotensin II receptor-mediated modulation of noradrenaline release from rat hypothalamic slices.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Brimonidine Tartrate; Hypothalamus; In Vitro Techniques; Levodopa; Male; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Angiotensin; Synapses; Yohimbine | 1993 |
Chronic administration does not alter the accumulation of L-dopa into muscle.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Carbidopa; Dopamine; Drug Therapy, Combination; Homovanillic Acid; Levodopa; Long-Term Care; Male; Metabolic Clearance Rate; Muscles; Rats; Rats, Wistar | 1994 |
Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetamides; Analysis of Variance; Animals; Anticonvulsants; Antiparkinson Agents; Brain; Carbidopa; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Levodopa; Macaca mulatta; Male; Motor Activity; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors | 1994 |
Depressor action of L-threo-dihydroxyphenylserine in the rat nucleus tractus solitarii.
Topics: Animals; Blood Pressure; Bradycardia; Depression, Chemical; Dose-Response Relationship, Drug; Droxidopa; Drug Interactions; Heart Rate; Hypotension; Levodopa; Male; Rats; Rats, Wistar; Solitary Nucleus; Stereoisomerism | 1996 |
MK-801 prevents levodopa-induced motor response alterations in parkinsonian rats.
Topics: Animals; Antiparkinson Agents; Benserazide; Dizocilpine Maleate; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease; Prosencephalon; Rats; Rats, Sprague-Dawley; Rotation | 1996 |
Intranasal administration of the dopaminergic agonists L-DOPA, amphetamine, and cocaine increases dopamine activity in the neostriatum: a microdialysis study in the rat.
Topics: Administration, Intranasal; Amphetamine; Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Agonists; Levodopa; Male; Microdialysis; Rats; Rats, Wistar; Sodium Chloride | 1997 |
L-DOPA cyclohexyl ester is a novel stable and potent competitive antagonist against L-DOPA, as compared to L-DOPA methyl ester.
Topics: Animals; Antiparkinson Agents; Blood Pressure; Dose-Response Relationship, Drug; Levodopa; Male; Microinjections; Rats; Rats, Wistar; Solitary Nucleus | 1997 |
MPTP-Induced hemiparkinsonism in nonhuman primates 6-8 years after a single unilateral intracarotid dose.
Topics: Animals; Antiparkinson Agents; Carotid Arteries; Dopamine Agents; Drug Administration Schedule; Female; Follow-Up Studies; Infusions, Intra-Arterial; Levodopa; Macaca nemestrina; Motor Activity; MPTP Poisoning; Parkinson Disease, Secondary; Rotation | 1998 |
Trihexyphenidyl potentiation of L-DOPA: reduced effectiveness three years later in MPTP-induced chronic hemiparkinsonian monkeys.
Topics: Animals; Antiparkinson Agents; Chronic Disease; Dopamine Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Female; Levodopa; Macaca nemestrina; MPTP Poisoning; Parkinson Disease, Secondary; Treatment Outcome; Trihexyphenidyl | 1998 |
Aromatic L-amino acid decarboxylase: conformational change in the flexible region around Arg334 is required during the transaldimination process.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alanine Racemase; Amino Acids; Aminoethylphosphonic Acid; Arginine; Aromatic-L-Amino-Acid Decarboxylases; Benzenesulfonates; Chromatography, High Pressure Liquid; Chymotrypsin; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Kinetics; Levodopa; Plasmids; Protein Binding; Protein Conformation; Spectrophotometry; Time Factors; Trypsin | 1998 |
[Is endogenously released DOPA itself an upstream factor for increase in glutamate release and delayed neuronal cell death induced by transient ischemia in rats?].
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Cell Death; Corpus Striatum; Dihydroxyphenylalanine; Glutamic Acid; Hippocampus; Hydrazines; Ischemic Attack, Transient; Levodopa; Male; Rats; Rats, Wistar | 1998 |
An L-dopaergic relay from the posterior hypothalamic nucleus to the rostral ventrolateral medulla and its cardiovascular function in anesthetized rats.
Topics: Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Catecholamines; Electric Stimulation; Heart Rate; Hypothalamus, Posterior; Levodopa; Male; Medulla Oblongata; Microdialysis; Rats; Rats, Wistar; Tetrodotoxin | 1999 |
L-dopaergic components in the caudal ventrolateral medulla in baroreflex neurotransmission.
Topics: alpha-Methyltyrosine; Animals; Aorta; Baroreflex; Blood Pressure; Catecholamines; Cobalt; Heart Rate; Levodopa; Male; Medulla Oblongata; Microinjections; Nervous System Physiological Phenomena; Phenylephrine; Pressoreceptors; Rats; Rats, Wistar; Solitary Nucleus; Synaptic Transmission | 1999 |
Nicotine alone and in combination with L-DOPA methyl ester or the D(2) agonist N-0923 in MPTP-induced chronic hemiparkinsonian monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Dopamine Agonists; Drug Interactions; Female; Levodopa; Macaca nemestrina; Motor Activity; Nicotine; Parkinson Disease, Secondary; Receptors, Dopamine D2; Rotation; Tetrahydronaphthalenes; Thiophenes | 1999 |
Effects of repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Caudate Nucleus; Corpus Striatum; Dopamine; Drug Resistance; Globus Pallidus; Levodopa; Male; Oxidopamine; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra | 2000 |
Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Cabergoline; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Drug Antagonism; Ergolines; Levodopa; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Synaptic Transmission | 2002 |
Kinetic characterisation of the reaction mechanism of mushroom tyrosinase on tyramine/dopamine and L-tyrosine methyl esther/L-dopa methyl esther.
Topics: Agaricales; Dopamine; Kinetics; Levodopa; Magnetic Resonance Spectroscopy; Monophenol Monooxygenase; Oxygen; Structure-Activity Relationship; Thermodynamics; Tyramine | 2002 |
Opposite modulation of regulators of G protein signalling-2 RGS2 and RGS4 expression by dopamine receptors in the rat striatum.
Topics: Animals; Benzazepines; Corpus Striatum; Dopamine Antagonists; In Situ Hybridization; Levodopa; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Dopamine D2; RGS Proteins; RNA, Messenger; Salicylamides | 2002 |
Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum.
Topics: Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Behavior, Animal; Body Weight; Cocaine; Corpus Striatum; Dopamine; Dopamine Agonists; Immunohistochemistry; Levodopa; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neurons; Proto-Oncogene Proteins c-fos; Receptors, Dopamine D1; Receptors, Opioid, mu; Signal Transduction; Sodium Chloride | 2002 |
Effects of (+/-)-idazoxan alone and in combination with L-DOPA methyl ester in MPTP-induced hemiparkinsonian monkeys.
Topics: Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Idazoxan; Levodopa; Macaca nemestrina; Parkinson Disease, Secondary; Time Factors | 2003 |
Determination of levodopa methyl ester and its metabolites in rat serum by CZE with amperometric detection.
Topics: Animals; Biotransformation; Buffers; Electrochemistry; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Levodopa; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Determination, purity assessment and chiral separation of levodopa methyl ester in bulk and formulation pharmaceuticals.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Levodopa; Pharmaceutical Preparations; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2006 |
L-dopa modulates motor cortex excitability in Alzheimer's disease patients.
Topics: Acetylcholine; Afferent Pathways; Aged; Aged, 80 and over; Alzheimer Disease; Cholinergic Agents; Dopamine; Dopamine Agents; Evoked Potentials, Motor; Female; Humans; Levodopa; Male; Middle Aged; Motor Cortex; Neural Inhibition; Neural Pathways; Nootropic Agents; Reaction Time; Synaptic Transmission; Time Factors; Transcranial Magnetic Stimulation | 2008 |
Biperiden enhances L-DOPA methyl ester and dopamine D(l) receptor agonist SKF-82958 but antagonizes D(2)/D(3) receptor agonist rotigotine antihemiparkinsonian actions.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Benzazepines; Biperiden; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Levodopa; Macaca nemestrina; Muscarinic Antagonists; Parkinsonian Disorders; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Thiophenes | 2008 |
Deep brain stimulation of the globus pallidus internus in the parkinsonian primate: local entrainment and suppression of low-frequency oscillations.
Topics: Action Potentials; Algorithms; Animals; Antiparkinson Agents; Deep Brain Stimulation; Disease Models, Animal; Elbow; Electric Stimulation; Female; Globus Pallidus; Levodopa; Macaca fascicularis; Neural Inhibition; Neurons; Parkinsonian Disorders; Periodicity; Time Factors | 2009 |
A feasibility study of differential delivery of levodopa ester and benserazide using site-specific intestinal loops in rats.
Topics: Animals; Antiparkinson Agents; Benserazide; Delayed-Action Preparations; Drug Combinations; Feasibility Studies; Infusion Pumps; Intestinal Absorption; Intestinal Mucosa; Intestines; Levodopa; Male; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2010 |
N-acetyl-L-methionyl-L-Dopa-methyl ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity.
Topics: Animals; Animals, Newborn; Antiparkinson Agents; Apoptosis; Cells, Cultured; Cytoprotection; Female; Glutathione; Heme Oxygenase-1; Levodopa; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Neurons; Oxidative Stress; Parkinson Disease; Pregnancy | 2010 |
Sustained-release formulation of levodopa methyl ester/benserazide for prolonged suppressing dyskinesia expression in 6-OHDA-leisoned rats.
Topics: Animals; Antiparkinson Agents; Benserazide; Delayed-Action Preparations; Disease Models, Animal; Dopamine Agents; Drug Combinations; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Reaction Time | 2011 |
Effects of l-dopa methyl ester on visual cortex injury induced by amblyopia and its underlying mechanism.
Topics: Amblyopia; Animals; Cats; Female; Levodopa; Male; Nerve Growth Factor; Nissl Bodies; Visual Cortex | 2012 |
Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats.
Topics: Animals; Antiparkinson Agents; Benserazide; Brain; Dopamine and cAMP-Regulated Phosphoprotein 32; Drug Carriers; Drug Delivery Systems; Dynorphins; Dyskinesia, Drug-Induced; Levodopa; Male; Microscopy, Electron, Scanning; Mitogen-Activated Protein Kinase Kinases; Nanomedicine; Nanoparticles; Particle Size; Phosphorylation; Proto-Oncogene Proteins c-fos; Rats; tau Proteins | 2012 |
L-dopa methyl ester attenuates amblyopia-induced neuronal injury in visual cortex of amblyopic cat.
Topics: Amblyopia; Animals; Apoptosis; Cats; Dopamine; Gene Expression; Levodopa; Neurons; Proto-Oncogene Proteins c-fos; Up-Regulation; Visual Cortex | 2013 |
Design and evaluation of levodopa methyl ester intranasal delivery systems.
Topics: Administration, Intranasal; Animals; Antiparkinson Agents; Chemistry, Pharmaceutical; Drug Delivery Systems; Hydrogen-Ion Concentration; Levodopa; Male; Nasal Mucosa; Rabbits; Serous Membrane; Time Factors | 2011 |
Pharmacokinetic evaluation of formulated levodopa methyl ester nasal delivery systems.
Topics: Administration, Intranasal; Animals; Biological Availability; Chemistry, Pharmaceutical; Drug Delivery Systems; Levodopa; Male; Rats; Rats, Sprague-Dawley | 2014 |
Early L-dopa, but not pramipexole, restores basal ganglia activity in partially 6-OHDA-lesioned rats.
Topics: Animals; Antiparkinson Agents; Basal Ganglia; Benserazide; Benzothiazoles; Corpus Striatum; Hippocampus; Levodopa; Male; Motor Activity; Neurogenesis; Oxidopamine; Parkinsonian Disorders; Pramipexole; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D3; Substantia Nigra; Time Factors | 2014 |
Potential transbuccal delivery of l-DOPA methylester prodrug: stability in the environment of the oral cavity and ability to cross the mucosal tissue.
Topics: Antiparkinson Agents; Drug Delivery Systems; Drug Stability; Levodopa; Mouth; Mouth Mucosa; Parkinson Disease; Prodrugs | 2016 |
Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine; Dopamine Agonists; Dyskinesia, Drug-Induced; Infusions, Intraventricular; Levodopa; Macaca; Male; Motor Activity; Parkinson Disease; Parkinsonian Disorders; Pilot Projects | 2020 |
Development and Validation of a New LC-MS/MS Bioanalytical Method for the Simultaneous Determination of Levodopa, Levodopa Methyl Ester, and Carbidopa in Human Plasma Samples.
Topics: Carbidopa; Chromatography, Liquid; Humans; Levodopa; Male; Middle Aged; Reproducibility of Results; Tandem Mass Spectrometry | 2023 |