levodopa has been researched along with tyrosine in 436 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 130 (29.82) | 18.7374 |
| 1990's | 95 (21.79) | 18.2507 |
| 2000's | 93 (21.33) | 29.6817 |
| 2010's | 94 (21.56) | 24.3611 |
| 2020's | 24 (5.50) | 2.80 |
| Authors | Studies |
|---|---|
| Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
| Cha, SH; Chairoungdua, A; Endou, H; Enomoto, A; Goya, T; Kanai, Y; Kim, DK; Kim, JY; Kobayashi, Y; Matsuo, H | 1 |
| Innocenti, A; Nishimori, I; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Innocenti, A; Nishimori, I; Onishi, S; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Innocenti, A; Kaila, K; Nishimori, I; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Nishimori, I; Pastorek, J; Pastorekova, S; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Nishimori, I; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Ferry, JG; Innocenti, A; Scozzafava, A; Supuran, CT; Zimmerman, SA | 1 |
| Arslan, O; Aydin, M; Guler, OO; Innocenti, A; Isik, S; Kockar, F; Scozzafava, A; Supuran, CT | 1 |
| Hilvo, M; Innocenti, A; Parkkila, S; Scozzafava, A; Supuran, CT | 1 |
| Hall, RA; Innocenti, A; Mühlschlegel, FA; Scozzafava, A; Supuran, CT | 1 |
| Innocenti, A; Leewattanapasuk, W; Manole, G; Mühlschlegel, FA; Scozzafava, A; Supuran, CT | 1 |
| Bertucci, A; Supuran, CT; Tambutté, S; Vullo, D; Zoccola, D | 1 |
| Capasso, C; Carginale, V; De Luca, V; Rossi, M; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Akdemir, A; Capasso, C; Carginale, V; De Luca, V; Rossi, M; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Sueishi, Y; Takemoto, T | 1 |
| Capasso, C; Del Prete, S; Supuran, CT; Vullo, D | 1 |
| AlOthman, Z; Capasso, C; Del Prete, S; Donald, WA; Osman, SM; Supuran, CT; Vullo, D | 1 |
| Mulder, AH; Schipper, J; Stoof, JC | 1 |
| Daniel, PM; Moorhouse, SR; Pratt, OE | 1 |
| Lane, JD; McBride, WJ; Shea, PA; Smith, JE | 1 |
| Butler, IJ; Koslow, SH | 1 |
| MacDonald, E; Pispa, JP | 1 |
| Dengler, HJ; Gugler, R; Hengstmann, JH | 1 |
| Bouyer, JJ; Dedet, L; Joseph, JP; Rougeul, A | 1 |
| Kameyama, T; Nabeshima, T | 1 |
| Hirooka, Y; Mitsuma, T; Nihei, N | 1 |
| Halbhübner, K; Herken, H; Kehr, W; Loos, D | 1 |
| Bunney, WE; Kopanda, RT; Murphy, DL | 1 |
| Brown, R; Carlsson, A; Snider, SR; Waldeck, B | 1 |
| Baldessarini, RJ; Harris, JE | 1 |
| Borri, P; Borri-Voltattorni, C; Minelli, A | 1 |
| Wirz-Justice, A | 1 |
| Awapara, J; Srinivasan, K | 1 |
| Lee, MS; Lee, TH | 1 |
| Bennett, JL; Boff, M; Seed, JL | 1 |
| Clay, KL; Murphy, RC | 1 |
| Kehr, W; Thiede, M; Zimmermann, R | 2 |
| Barbeau, A; Bélanger, F; Butterworth, RF | 1 |
| Bradford, HF; De Belleroche, J | 1 |
| Carlsson, A | 1 |
| Poirier, LJ | 1 |
| Ekel, TM; Hearing, VJ | 1 |
| Frei, E; Wick, MM | 1 |
| Cooper, RL; Linnoila, M | 2 |
| Schulte, J | 1 |
| Neuhoff, V; Vaughan, PF | 1 |
| Burlet, DB | 1 |
| Maître, L; Waldmeier, PC | 1 |
| Kehr, W | 1 |
| Tissot, R | 1 |
| Corne, SJ; Goodwin, BL; Johnson, RD; Ruthven, CR; Sandler, M; Stephens, RJ | 1 |
| Alper, A; Dougher, GJ; Finch, CE; Hody, G; Jonec, V; Morton-Smith, W; Walker, JP | 1 |
| Birkmayer, W; Danielczyk, W; Neumayer, E; Riederer, P | 1 |
| Costall, B; Naylor, RJ | 1 |
| Creese, I; Iversen, SD | 1 |
| Kato, T; Kooi, M; Ozawa, H; Sugawara, K | 1 |
| Bykhovskaia, KM; Matlina, EA; Vaĭsman, SM; Vasil'ev, VN | 1 |
| Cotzias, GC; Tang, LC | 1 |
| Clayton, PT; Hyland, K | 1 |
| Itoh, T; Kamisaki, Y; Takao, Y | 1 |
| Hasegawa, S; Konagaya, Y; Maruyama, W; Mokuno, K; Nakahara, D; Naoi, M; Takahashi, A; Watanabe, H | 1 |
| Aimola, P; Lanza, B; Miranda, M; Pacioni, G; Ragnelli, AM | 1 |
| Melamed, E | 1 |
| Bjurling, P; Gillberg, PG; Långström, B; Miwa, S; Odano, I; Watanabe, Y; Yumoto, N | 1 |
| Sgaragli, GP; Tipton, KF; Valoti, M | 1 |
| Kaakkola, S; Männistö, PT; Tuomainen, P; Wurtman, RJ | 1 |
| Antoni, G; Bjurling, P; Långström, B; Malmborg, P; Watanabe, Y | 1 |
| Jenner, P; Marsden, CD; Rose, S | 2 |
| Abe, T; Kikuchi, T; Nozaki, Y; Takahashi, S; Tohgi, H | 1 |
| Deleu, D; Ebinger, G; Michotte, Y; Sarre, S | 3 |
| Deleu, D; Ebinger, G; Herregodts, P; Michotte, Y; Sarre, S | 1 |
| Wikberg, T | 1 |
| Cedarbaum, JM; Guttman, M; Leger, G | 1 |
| Slominski, A | 2 |
| Brown, JW; Freeman, GB; Ieni, JR; Soblosky, JS; Thurmond, JB | 1 |
| Colzi, A; Da Prada, M; Zürcher, G | 1 |
| August, TF; Bayne, WF; Eisenhandler, R; Musson, DG; Titus, DC; Yeh, KC | 1 |
| Chattopadhyay, S; Das, A | 1 |
| De Herdt, P; Maitre, L; Waldmeier, PC | 1 |
| Appelman, EH; DeJesus, OT; Mukherjee, J; Nickles, JR; Sunderland, JJ | 1 |
| Bordet, S; Commissiong, JW; Karoum, F; Zhang, C | 1 |
| Faull, KF; Maddaluno, JF | 1 |
| Glatt, H | 1 |
| Fujitake, J; Kuno, S; Mizuta, E | 1 |
| Cedarbaum, JM; Guttman, M; Léger, G; Reches, A | 1 |
| Paus, R; Slominski, A | 2 |
| Hyland, K; Surtees, R | 1 |
| Dissing, IC; Gerdes, AM; Güttler, F; Lou, H; Lykkelund, C; Pakkenberg, H; Rasmussen, V | 1 |
| Jastreboff, P; Pawelek, J; Slominski, A | 1 |
| Cedarbaum, JM; Kutt, H; McDowell, FH | 2 |
| August, TF; Bush, DF; Lasseter, KC; Musson, DG; Schwartz, S; Smith, ME; Titus, DC; Yeh, KC | 1 |
| Berchou, RC; Galloway, MP; Kareti, D; Kesaree, N; LeWitt, PA; Nelson, MV; Schlick, P | 1 |
| Borisenko, SA | 1 |
| Luquin, MR; Obeso, JA; Vaamonde, J | 1 |
| Baruzzi, A; Contin, M; Martinelli, P; Procaccianti, G; Riva, R | 1 |
| de Jong, AP; Haan, EA; Manson, JI; Ouvrier, RA; Wadman, SK; Wise, GA | 1 |
| Boomsma, F; Hovestadt, A; Man in't Veld, AJ; Meerwaldt, JD; Schalekamp, MA | 1 |
| Hisaka, A; Ihara, M; Sawasaki, Y; Takehana, H; Tomimoto, K; Tsuchiya, Y; Yano, M | 1 |
| Cohen, Y; el Gemayel, G; Jacquot, C; Prioux-Guyonneau, M; Trouvin, JH | 1 |
| Lee, M; Nohta, H; Ohkura, Y; Umegae, Y | 1 |
| Nagatsu, T; Naoi, M; Takahashi, T | 1 |
| Bretton, C; Hof, P; Ofori, S; Schorderet, M | 1 |
| Lindström, P; Ohlsson, L | 1 |
| Cabanes, J; García-Cánovas, F; García-Carmona, F; Lozano, JA | 1 |
| Da Prada, M; Haefely, WE; Kettler, R; Schaffner, R; Zürcher, G | 1 |
| Bolognia, J; McLane, J; Murray, M; Osber, M; Pawelek, J; Słominski, A | 1 |
| Pawelek, J; Slominski, A | 1 |
| Bomirski, A; Kuklinska, E; Moellmann, G; Pawelek, J; Słominski, A | 1 |
| Kaakkola, S; Lindén, IB; Männistö, PT; Nissinen, E; Pohto, P; Schultz, E | 1 |
| Aime, S; Crippa, PR | 1 |
| De Jesus, OT; Mukherjee, J | 1 |
| Reimherr, FW; Ward, M; Wender, PH; Wood, DR | 1 |
| Lindström, P; Sehlin, J | 1 |
| Berman, ML; Tennant, F | 1 |
| Allen, JG; Bird, H; Malcolm, SL; Marion, MH; Marsden, CD; O'Leary, CG; Quinn, NP | 1 |
| Allen, JG; Hardie, RJ; Lees, AJ; Malcolm, SL; Stern, GM | 1 |
| Chase, TN; Fabbrini, G; Juncos, JL; Mouradian, MM; Serrati, C | 1 |
| Gancher, ST; Merrick, D; Nutt, JG; Woodward, WR | 1 |
| Abdallah, RM; Meadows, GG; Starkey, JR | 1 |
| Bennett, BA; Freed, CR | 1 |
| Meadows, GG; Pierson, HF | 2 |
| Blonder, J; Cohen, BE; Normand, M; Peled, I; Quint, J; Szeinberg, A | 1 |
| Reches, A | 1 |
| McConnell, H | 1 |
| Gergely, A; Kiss, T | 1 |
| Rorie, DK; Tyce, GM | 1 |
| Bermejo Pareja, F; de Yébenes, JG; Martinez-Martin, P; Muradas, V | 1 |
| Hirose, S; Ishimitsu, T | 1 |
| Eplov, L; Nielsen, M; Scheel-Krüger, J | 1 |
| Kohsaka, M; Mori, A; Takeuchi, H | 1 |
| Colombo, JP; Küffer, H; Peheim, E; Richterich, R | 1 |
| Granerus, AK; Jagenburg, R; Rödjer, S; Svanborg, A | 1 |
| Boulton, AA; Wu, PH | 1 |
| Andén, NE; Engel, J | 1 |
| Merzel, J; Raw, I; Schmidt, BJ | 1 |
| Carlsson, A; Eriksson, T; Hagman, M; Jagenburg, R | 1 |
| Hakim, AA | 1 |
| Haubrich, DR; Pflueger, AB | 1 |
| Bullard, WP; Capson, TL | 1 |
| Fernstrom, JD; Fernstrom, MH; Volk, EA | 1 |
| Zavodskaya, IS | 1 |
| Jergil, B; Lindbladh, C; Rorsman, H; Rosengren, E | 1 |
| Brown, JW; Kramarcy, NR; Thurmond, JB | 1 |
| Muldoon, SM; Rorie, DK; Tyce, GM | 1 |
| Fellman, JH; Nutt, JG | 1 |
| Barnett, TA; Hageman, JH; Riner, S; Valenzuela, D | 1 |
| DiSorbo, DM; Harris, NA; Nathanson, L | 1 |
| Beers, MF; Hurtig, H; Melvin, G; Scarpa, A; Stern, M | 1 |
| Stern, L; Tenenhouse, A; Yu, EW | 1 |
| Blagoeva, PM | 1 |
| Asahara, K; Hirose, S; Imaizumi, M; Ishimitsu, T | 1 |
| Aguado, EG; Bazán, E; de Yébenes, JG; Gervas, JJ; Muradás, V | 1 |
| Baldessarini, RJ | 1 |
| Bennett, JL; Kilts, CD; Seed, JL | 1 |
| Nellaiappan, K; Ramalingam, K | 1 |
| Lubahn, DB; McCarty, KS; Seigler, HF; Stowers, S; Wortman, J | 1 |
| Fahn, S; Prasad, AL | 1 |
| Carlsson, A; Eriksson, T | 1 |
| Lipke, H; Luther, JP | 1 |
| Abdallah, RM; Desai, PR; Meadows, GG; Pierson, HF | 1 |
| Fahn, S; Reches, A | 1 |
| Porter, JC; Reymond, MJ | 1 |
| Fahn, S; Mielke, LR; Reches, A | 1 |
| Riederer, P | 1 |
| Bowers, RR; Hadfield, TL; Shieh, SJ | 1 |
| Altar, A; Goldwag, D; Lytle, LD; Terry, RL | 1 |
| Wick, MM | 1 |
| Baines, AD; Chan, W | 1 |
| Bagchi, P; Bagchi, SP; Smith, TM | 1 |
| Deleu, D; Ebinger, G; Michotte, Y; Sarre, S; Van Belle, K | 1 |
| Kaakkola, S; Kask, A; Männistö, PT; Törnwall, M; Tuomainen, P | 1 |
| Abe, T; Saheki, M; Takahashi, S; Tohgi, H; Tsukamoto, Y; Yamazaki, K | 1 |
| Carey, RJ; Dai, H; Huston, JP; Pinheiro-Carrera, M; Schwarting, RK; Tomaz, C | 1 |
| Hashiguti, H; Ikeda, T; Maruyama, W; Nakahara, D; Naoi, M | 1 |
| Callaghan, S; Gardner, ML; Lindsey, NJ; Schallreuter-Wood, KU; Wood, JM | 1 |
| Cheng, J; Eisner, M; Moss, SC; Zschack, P | 1 |
| García-Borrón, JC; Jiménez-Cervantes, C; Lozano, JA; Solano, F | 1 |
| Himori, N; Mishima, K | 1 |
| Aruoma, OI; Dexter, DT; Evans, PJ; Halliwell, B; Jenner, A; Jenner, P; Kaur, H; Lees, AJ; Marsden, DC; Spencer, JP | 1 |
| Acerbi, D; Mariotti, F; Rondelli, I; Ventura, P | 1 |
| Bredberg, E; Lennernäs, H; Paalzow, L | 1 |
| Fernandes, MH; Pinto-do-O, PC; Soares-da-Silva, P | 1 |
| Akaike, N; Himori, N; Kurasawa, M; Mishima, K; Tanaka, Y | 1 |
| Bostian, KA; Foor, F; Morin, N | 1 |
| Garcia-Borron, JC; Jimenez-Cervantes, C; Lozano, JA; Solano, F; Valverde, P | 1 |
| Balaraman, K; Hoti, SL | 1 |
| Batterman, S; Pras, N; Van Uden, W; Visser, JF; Woerdenbag, HJ | 1 |
| Bennett, JP; Schuh, LA | 1 |
| Baraldo, M; Benetello, P; Furlanut, M; Hassan, E; Zara, G | 1 |
| Carter, JH; Gancher, ST; Hammerstad, JP; Nutt, JG; Woodward, W | 1 |
| Gordin, A; Harjola, VP; Karlsson, M; Keränen, T; Korpela, K; Pentikäinen, PJ; Rita, H; Seppälä, L; Wikberg, T | 1 |
| Cohen, G; DiRocco, A; Merchant, CA; Molinari, S; Moros, D; Mytilineou, C; Yahr, MD | 1 |
| Chang, WY; Webster, RA | 1 |
| Rinne, UK; Ruottinen, HM | 1 |
| Channing, MA; Eckelman, WC; Kawai, K; Kubodera, A; Ohta, H | 1 |
| Joseph, JA; Miller, JW; Selhub, J | 1 |
| Antila, S; Gordin, A; Keränen, T; Koulu, M; Scheinin, M; Sundberg, S; Wikberg, T | 1 |
| Bai, G; Christensen, BM; Li, J; Yoshino, TP | 1 |
| Brenci, S; Indiveri, F; Lotti, G; Musso, NR; Setti, M | 1 |
| Achilli, G; Banting, A; Banting, S; Le Bars, D; Weil-Fugazza, J | 1 |
| O'Connell, MT; Patsalos, PN; Quinn, NP; Tison, F | 1 |
| Brannan, T; Prikhojan, A; Yahr, MD | 1 |
| Misu, Y; Miyamae, T; Okumura, Y; Ueda, H; Yue, JL | 1 |
| Misu, Y; Miyamae, T; Ueda, H; Yue, JL | 1 |
| Brenci, S; Indiveri, F; Lotti, G; Musso, NR | 2 |
| Hattori, Y; Kanazawa, I; Kowa, H; Kuno, S; Mizuno, Y; Narabayashi, H; Tohgi, H; Tsukamoto, Y; Yamamoto, M; Yanagisawa, N; Yokochi, M | 1 |
| Crevoisier, C; Dingemanse, J; Kleinbloesem, CH; Wood, ND; Zürcher, G | 1 |
| Baraldo, M; Benetello, P; Fortunato, M; Furlanut, M; Pea, F | 1 |
| Benedito, E; Cubillana, JD; García-Borrón, JC; Jiménez-Cervantes, C; Jiménez-Cervantes, J; Lozano, JA; Meyer zum Gottesberge, AM; Pérez, D; Solano, F | 1 |
| Antkiewicz-Michaluk, L; Krygowska-Wajs, A; Romańska, I; Szczudlik, A; Vetulani, J | 1 |
| Bousquet, B; Garnier, JP; Letellier, S; Spy, J | 1 |
| Blandini, F; Desideri, S; Martignoni, E; Nappi, G; Pacchetti, C; Rivellini, D | 1 |
| Gies, C; Gleiter, CH; Löschmann, PA; Luippold, G; Mühlbauer, B | 1 |
| Carlsson, A; Fasth, KJ; Hartvig, P; Långström, B; Neu, H; Sonesson, C; Tedroff, J; Torstenson, R; Waters, N | 1 |
| Crevoisier, C; Dingemanse, J; Gasser, UE; Kleinbloesem, CH; Lankhaar, G | 1 |
| Jaskowski, P; Kömpf, D; Moser, A; Siebecker, F; Vieregge, P | 1 |
| Hearing, VJ; Potterf, SB | 1 |
| Crevoisier, C; Dingemanse, J; Gasser, UE; Lankhaar, G; Ouwerkerk, M | 1 |
| Cohen, G; Dembiec-Cohen, D; Yakushin, S | 1 |
| Beiske, A; Fotteler, B; Jorga, KM; Larsen, JP; Moe, B; Schleimer, M; Schmitt, M | 1 |
| Buchholz, J; Iacono, RP; Kuniyoshi, S; Liu, H; Schoonenberg, T | 1 |
| Furlanut, M; Wu, G | 1 |
| Schoser, BG; Stuerenburg, HJ | 1 |
| Blandini, F; Desideri, S; Godi, L; Mancini, F; Martignoni, E; Nappi, G; Pacchetti, C | 1 |
| Gomes, P; Soares-da-Silva, P | 1 |
| Baccard, M; Bousquet, B; Garnier, JP; Kerneis, Y; Le Bricon, T; Letellier, S; Revol, M; Spy, J; Stoitchkov, K | 1 |
| Asmakova, LS; Bondarenko, NA; Gudasheva, TA; Kalinina, TS; Ostrovskaya, RU; Seredenin, SB; Voronina, TA; Zaitseva, NI | 1 |
| Blandini, F; di Jeso, F; Martignoni, E; Nappi, G; Ricotti, R | 1 |
| Chung, HY; Jun, YS; Kim, YJ; No, JK; Rhee, SH; Shim, KH; Soung, DY; Yokozawa, T | 1 |
| Bareiss, M; Blessing, H; Carvey, P; Jankowski, S; Ling, ZD; Schwarz, J; Storch, A | 1 |
| Jackson, M; Jenner, P; Treseder, SA | 1 |
| Chen, C; Wilcoxen, K; Zhu, YF | 1 |
| Alves, TL; Carvalho, GM; Freire, DM | 1 |
| Bankiewicz, KS; Bringas, J; Budinger, TF; Cunningham, J; Eberling, JL; Harvey-White, J; Jagust, W; Kohutnicka, M; Pivirotto, P | 1 |
| Bräutigam, C; Hoffman, GF; Hyland, K; Knust, A; Sharma, RK; Wevers, RA | 1 |
| Liu, MC; Ranasinghe, JG; Sakakibara, Y; Suiko, M | 1 |
| Chang, JY; Liu, LZ | 1 |
| Franceschi, C; Galeazzi, L; Giunta, S; Ronchi, P; Valli, B | 1 |
| DeJesus, OT; Stein, TD | 1 |
| Jenner, P; Rose, S; Treseder, SA | 1 |
| Ikota, N; Matsushima, Y; Nakagawa, H; Ozawa, T; Sumiki, E | 1 |
| Blandini, F; Fancellu, R; Mangiagalli, A; Martignoni, E; Nappi, G; Pacchetti, C; Samuele, A | 1 |
| Hainzl, D; Loureiro, AI; Parada, A; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Fenoll, LG; García-Cánovas, F; García-Ruiz, PA; García-Sevilla, F; Rodríguez-López, JN; Tudela, J; Varón, R | 1 |
| Charlton, CG; Lamango, N; Latinwo, L; Lee, ES; Liu, XX; Zhao, WQ | 1 |
| Buhmann, C; Oechsner, M; Strauss, J; Stuerenburg, HJ | 1 |
| Benzie, IF; Buswell, JA; Shi, YL | 1 |
| Ali, S | 1 |
| Fowler, B; Kuhn, W; Müller, T; Woitalla, D | 1 |
| Bousquet, B; Garnier, JP; Ghanem, G; Le Bricon, T; Letellier, S; Morel, P; Stoitchkov, K; Tsankov, N | 2 |
| Calvi-Gries, F; Crevoisier, C; Nilsen, T; Zerr, P | 1 |
| Bandmann, O; Deuschl, G; Goertz, M; Hefter, H; Hoffmann, G; Jost, W; Müller, U; Oertel, W; Zöfel, P; Zschocke, J | 1 |
| Maass, A; Moser, A; Scholz, J | 1 |
| Amicarelli, F; Bonfigli, A; Cesare, P; Miranda, M; Pacioni, G; Zarivi, O | 1 |
| Ali, S; Haq, I; Iqbal, J; Qadeer, MA | 1 |
| Ipe, BI; Mahima, S; Thomas, KG | 1 |
| Blandini, F; Bono, G; Calandrella, D; Fancellu, R; Mangiagalli, A; Martignoni, E; Nappi, G; Pacchetti, C; Riboldazzi, G; Samuele, A | 1 |
| IMAIZUMI, R; KANIIKE, K; NAMBA, J; YOSHIDA, H | 1 |
| Almeida, L; Falcão, A; Loureiro, A; Machado, R; Maia, J; Silveira, P; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Bertram, HJ; Ley, JP | 1 |
| Bergquist, J; Markides, KE; Sjöberg, PJ; Törnkvist, A | 1 |
| Kudrin, VS; Lavrentyeva, AV; Melnikova, VI; Rayevsky, KS; Ugrumov, MV | 1 |
| Masuda, N; Nagae, Y; Nakashima, A; Niina, M; Saxer, C | 1 |
| Schmidt, WJ; Srinivasan, J | 1 |
| Fuxe, K; Owman, C | 1 |
| Arnold, LA; Egami, K; Hyland, K; Jinnah, HA; Kasim, S | 1 |
| Muhlack, S; Müller, T; Przuntek, H; Twiehaus, S; Welnic, J; Woitalla, D | 1 |
| Fang, B; He, W; Ruan, L; Shen, P; Wang, Y; Yu, Z | 1 |
| Kudrin, VS; Lavrent'eva, AV; Mel'nikov, VI; Raevskiĭ, KS; Ugriumov, MV | 1 |
| Ali, S; Haq, IU; Qadeer, MA; Rajoka, MI | 1 |
| Birk Møller, L; Diepold, K; Güttler, F; Hougaard, P; Romstad, A; Rostasy, K; Schütz, B; Wilken, B | 1 |
| Kudrin, VS; Lavrent'eva, AV; Mel'nikova, VI; Raevskii, KS; Ugryumov, MV | 1 |
| Benkelfat, C; Casey, KF; Delaney, JS; Kolivakis, T; Leyton, M | 1 |
| Bonnet, S; Boumendjel, A; Mariotte, AM; Okombi, S; Perrier, E; Rival, D | 1 |
| Casadevall, A; Chaskes, S; Dadachova, E; Frases, S | 1 |
| Huang, Y; Li, B; Paskewitz, SM | 1 |
| Benkelfat, C; Casey, KF; Leyton, M; Young, SN | 1 |
| Carl, JL; Karimi, M; Loftin, S; Perlmutter, JS | 1 |
| Bremen, D; Erdmann, C; Goetze, O; Muhlack, S; Müller, T; Przuntek, H; Woitalla, D | 1 |
| Abe, T; Isobe, C; Kikuchi, T; Murata, T; Sato, C; Terayama, Y | 1 |
| Fukui, Y; Han, SY; Jeong, YG; Kawk, JH; Kim, CT; Lee, NS; Sawada, K | 1 |
| Elsinga, PH; Hatano, K; Ishiwata, K | 1 |
| Gülçin, I | 1 |
| Muhlack, S; Müller, T; Welnic, J | 1 |
| Sikander, A | 1 |
| Fujii, Y; Furubayashi, A; Hiradate, S | 1 |
| Baccard, M; Basset-Seguin, N; Bousquet, B; Cassinat, B; Dubertret, L; Garnier, JP; Kerob, D; Le Bricon, T; Lebbé, C; Letellier, S; Morel, P; Stoitchkov, K | 1 |
| aan het Rot, M; Baker, GB; Benkelfat, C; Booij, L; Leyton, M; Young, SN | 1 |
| Ander, L; Kolf, K; Muhlack, S; Müller, T; Woitalla, D | 1 |
| Flieger, M; Novotná, J; Olsovská, J; Spízek, J | 1 |
| Gao, H; Kawabata, J; Nishida, J; Saito, S | 1 |
| Ali, S; Shultz, JL | 1 |
| Charlton, C; Chen, H; King, J; Lee, ES | 1 |
| Carton, Y; Kohler, LJ; Mastore, M; Nappi, AJ | 1 |
| Jiang, L; Luo, WC; Xiao, T; Xie, XY; Xue, CB; Yan, L | 1 |
| Acharya, C; Kumar, V; Kundu, SC; Sen, R | 1 |
| Nucci, NV; Scott, JN; Vanderkooi, JM | 1 |
| Amaral, VG; Carducci, C; Giovanniello, T; Lorenzoni, PJ; Scola, RH; Teive, HA; Werneck, LC | 1 |
| Casadevall, A; Dadachova, EA; Howell, RC; Schweitzer, AD | 1 |
| Barrett, SP; Benkelfat, C; Brunelle, C; Leyton, M; Pihl, RO; Young, SN | 1 |
| Kim, DS; Park, KC; Park, SH; Shin, JW; Youn, SW | 1 |
| Decatur, CL; Lopez, VM; Lynch, RM; McKay, BS; Stamer, WD | 1 |
| Wang, Q; Ye, R; Zhou, X | 1 |
| Almeida, L; Costa, R; Falcão, A; Lopes, C; Loureiro, AI; Machado, R; Nunes, T; Rocha, J; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Asmus, F; Doherty, E; Gasser, T; King, MD; Langseth, A; Lynch, T; Munz, M; Nestor, T | 1 |
| Krishnaveni, R; Neelgund, YF; Rathod, V; Thakur, MS | 1 |
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| Kuhn, W; Müller, T | 1 |
| Li, SB; Lv, XY; Nie, HL; Qiu, T; Xue, Y; Zhang, HT; Zhou, LM; Zhu, LM | 1 |
| Ates, B; Aytan, E; Geckil, H; Kurt, AG; Ozer, U | 1 |
| Muhlack, S; Müller, T | 2 |
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| Acosta, JR; García-Cánovas, F; García-Molina, F; García-Ruiz, PA; Munoz-Munoz, JL; Rodríguez-López, JN; Tudela, J | 1 |
| Almeida, L; Costa, R; Falcão, A; Fernandes-Lopes, C; Loureiro, AI; Machado, R; Nunes, T; Rocha, JF; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Hsu, FL; Hsu, KY; Lin, SJ; Uang, YS; Wang, LH; Yang, LM | 1 |
| Min, K; Park, DH; Yoo, YJ | 1 |
| Dean, RT; Foxwell, AR; Nelson, M; Tyrer, P | 1 |
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| Adamiak, U; Bialecka, M; Gawronska-Szklarz, B; Kaldonska, M; Klodowska-Duda, G; Safranow, K; Wyska, E | 1 |
| Chaube, R; Chourasia, TK; Joy, KP; Singh, V | 1 |
| Andreoni, S; Begni, B; Brighina, L; Difrancesco, JC; Ferrarese, C; Galbussera, A; Piazza, F; Piolti, R; Prigione, A | 1 |
| Jadhav, JP; Surwase, SN | 1 |
| Houlden, H; Paisán-Ruiz, C | 1 |
| Ali, S; Haq, I | 1 |
| Brunk, UT; Dunlop, RA; Rodgers, KJ | 1 |
| García-Cánovas, F; García-Molina, F; García-Ruíz, PA; Martínez-Ortiz, F; Muñoz-Muñoz, JL; Rodríguez-López, JN; Tudela, J | 1 |
| Cheng, C; Gao, J; Guo, Y; Jin, X; Li, K; Li, Y; Wang, J; Wang, Z | 1 |
| Kream, RM; Ptáček, R; Stefano, GB | 1 |
| Bolívar, F; de Anda, R; Gosset, G; Hernández-Chávez, G; Martínez, A; Muñoz, AJ | 1 |
| Muhlack, S; Müller, T; Woitalla, D | 1 |
| Bendigiri, C; Kumar, AR; Pimprikar, P; Rao, A; Zinjarde, S | 1 |
| Blau, N; Dill, P; Jakobs, C; Schneider, J; Tekin, M; Thöny, B; Trachsel, D; Weber, P | 1 |
| Pawelek, J; Slominski, A; Zmijewski, MA | 1 |
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| Choi, YJ; Chung, HY; Ha, YM; Kim, JA; Kim, JM; Lee, EK; Lee, HJ; Lee, JY; Moon, HR; Park, D; Park, JY; Park, YJ | 1 |
| Khan, MH; Kumar, V; Raghavendra, S; Ramesh, CK | 1 |
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| Ishihara, A; Kihira, K; Kimura, Y; Matsumoto, M; Miyachi, T; Nakamura, T; Ohtsuki, T; Yamawaki, T | 1 |
| Delépée, R; Maunit, B; Salwiński, A | 1 |
| Askmark, H; Johansson, A; Lennernäs, H; Nyholm, D | 1 |
| Krzyściak, W | 1 |
| Kubo, I; Satooka, H | 1 |
| Baker, H; Morgan, LD; Patel, BA; Yeoman, MS | 1 |
| Apine, OA; Jadhav, JP; Patil, SA; Surwase, SN | 1 |
| Andolina, D; Cabib, S; Conversi, D; Cruciani, F; Giacovazzo, G; Pascucci, T; Puglisi-Allegra, S | 1 |
| Devreese, B; Dolashki, A; Gushterova, A; Tchorbanov, B; Van Beeumen, J; Voelter, W | 1 |
| Hirosawa, T; Kihira, K; Kimura, Y; Onzawa, Y; Shirasuna, M; Taogoshi, T; Uzuhashi, K | 1 |
| Kadam, RS; Kompella, UB; Scheinman, RI | 1 |
| Castellar, MR; Obón, JM; Solano, F | 1 |
| Ho, A; Peritore, CS; Schaus, SE; Yamamoto, BK | 1 |
| Fukui, M; Kang, KS; Wen, Y; Yamabe, N; Zhu, BT | 1 |
| Chatamra, K; Dutta, S; Johansson, A; Locke, C; Nyholm, D; Odin, P; Othman, AA | 1 |
| Adir, N; Fishman, A; Goldfeder, M; Kanteev, M | 1 |
| Blau, N; Hoffmann, GF; Kühn, AA; Opladen, T | 1 |
| García-Cánovas, F; García-Molina, F; García-Molina, Mdel M; García-Ruiz, PA; Muñoz-Muñoz, JL; Rodríguez-López, JN; Varon, R | 1 |
| Blais, E; Gupta, P; Hannan, M; Kumarathasan, P; Mitchel, R; Saravanamuthu, A; Trivedi, A; Vincent, R; Whitman, S; Wyatt, H | 1 |
| Bapat, V; Inamdar, S; Jadhav, J; Joshi, S | 1 |
| Ali, S; Rizvi, N | 1 |
| Bendlin, BB; Buyan-Dent, L; Christian, BT; DeJesus, OT; Gallagher, CL; Harding, SJ; Holden, JE; Li, CT; Nickles, RJ; Oh, J; Okonkwo, O; Palotti, M; Stone, CK | 1 |
| Kohno, M; Niwano, Y; Tada, M | 1 |
| Ba, M; Kong, M; Liu, C; Qiu, H; Zhang, H; Zhang, Y | 1 |
| Cardoso, MA; de Carvalho, KA; de Francisco, TM; de Oliveira Vilhena, R; Gasparetto, JC; Guimarães de Francisco, TM; Martins, CA; Pontarolo, R; Ribeiro, RP | 1 |
| Chai, B; Chen, X; Qiao, Y; Qiu, C; Wang, H | 1 |
| Cao, L; Hao, H; Hao, K; Li, F; Liu, H; Qi, Q; Wang, H | 1 |
| Berna, J; Garcia-Canovas, F; Garcia-Molina, Mdel M; Ortiz-Ruiz, CV; Tomas, V; Tudela, J | 1 |
| Fukuda, K | 1 |
| Garcia-Canovas, F; Garcia-Molina, Mdel M; Maria-Solano, MA; Ortiz-Ruiz, CV; Tomas, V; Tudela, J; Varon, R | 1 |
| Ballesta de Los Santos, M; Berna, J; Fenoll, J; Garcia-Canovas, F; Garcia-Ruiz, PA; Ortiz-Ruiz, CV; Tudela, J | 1 |
| Harada, N; Kakiuchi, T; Kanazawa, M; Muramatsu, S; Ohba, H; Tsukada, H | 1 |
| Imai, Y; Kanaoka, T; Ochiai, A; Tanaka, S; Tanaka, T; Taniguchi, M; Yoshida, H | 1 |
| Bennett, MR; Law, BJ; Micklefield, J; Shepherd, SA; Struck, AW; Wong, LS; Zhuo, Y | 1 |
| Akhavan, N; Bean, A; Brown, M; Gonzalez, A; Hatlestad, G; Lloyd, A; Sunnadeniya, R; Symonds, VV | 1 |
| Baba, T; Inoue, Y; Kohno, M; Miyaji, A | 1 |
| Bishnoi, P; Charde, SY; Raut, PP | 1 |
| Asensio, MJ; García-Sanz, P; Herranz, AS; Moratalla, R; Solís, O | 1 |
| Abebe, A; Evans, J; Sugumaran, M; Zheng, D | 1 |
| Asanuma, M; Miyazaki, I | 1 |
| Chai, WM; Peng, Y; Wang, R; Wei, MK; Yang, Q | 1 |
| Kreis, K; Kuntner, C; Langer, O; Mairinger, S; Muchitsch, V; Stanek, J; Wanek, T; Wingelhofer, B | 1 |
| Bryjak, J; Cieńska, M; Koźlecki, T; Labus, K; Lewańczuk, M; Liesiene, J | 1 |
| Chen, LS; Chen, QX; Cui, Y; Hu, YH; Wang, Q; Yu, F; Zheng, J | 1 |
| Herrman, L; Kinkel, M; Muhlack, S; Müller, T | 1 |
| Choi, DK; Kim, BW; Lee, HU; Park, JY; Yoon, SH | 1 |
| Berna, J; Garcia-Canovas, F; Garcia-Jimenez, A; Garcia-Ruiz, PA; Rodríguez-López, JN; Saura-Sanmartin, A; Teruel-Puche, JA | 1 |
| Fogliano, V; Janssen, RH; Lakemond, CMM; Renzone, G; Scaloni, A; Vincken, JP | 1 |
| Arce, CA; Bisig, CG; Dentesano, YM; Ditamo, Y; Hansen, C | 1 |
| Dhawan, SS; Lal, RK; Shanker, K; Singh, M; Singh, SK | 1 |
| Li, Y; Macka, M; Nesterenko, PN; Paull, B; Stanley, R | 1 |
| Suo, H; Tang, XL; Zheng, RC; Zheng, YG | 1 |
| Azagury, A; Cho, DY; Estrellas, KM; Fiecas, M; Furtado, S; Laulicht, B; Mancini, A; Mathiowitz, E; Reineke, J | 1 |
| Chen, Y; Chu, H; Feng, W; Liu, W | 1 |
| Bian, N; Bu, X; Hao, D; Li, Y; Liu, H; Pei, J; Wang, J; Zhang, F; Zhang, X; Zhen, X | 1 |
| Hassanvand, Z; Jalali, F | 1 |
| Burman, J; Emami Khoonsari, P; Herman, S; Kultima, K; Landtblom, AM; Niemelä, V; Nyholm, D; Spjuth, O; Sundblom, J | 1 |
| Barba, P; Cline, GW; Febres, G; Harris, PE; Korner, J; Leibel, RL; Maffei, A; Rayat, GR; Slifstein, M | 1 |
| Adipah, FK; Du, G; Fordjour, E; Zhou, J; Zhou, S | 1 |
| Ding, Y; Lu, XY; Ran, GQ; Tan, D; Zhao, JP; Zhu, XL | 1 |
| Balskus, EP; Bess, EN; Bisanz, JE; Maini Rekdal, V; Turnbaugh, PJ | 1 |
| Artamonova, A; Hayes, KC; Koledova, VV; Rha, C; Sambanthamurthi, R; Schneider, K; Sinskey, AJ; Subramaniam, A; Weinberg, RP | 1 |
| Du, D; Guo, N; Liu, W; Shang, Q; Wu, Y; You, X; Zhang, L | 1 |
| Bentley, WE; Hörnström, D; Järbur, I; Payne, GF; Pitzer, J; Sjöberg, G; van Maris, AJA; VanArsdale, E | 1 |
| Gözaydın, G; Han, X; Liang, H; Ma, X; Ning, W; Poon, NY; Yan, N; Yang, H; Zhou, K | 1 |
| Tang, XL; Zheng, RC; Zheng, YG; Zhu, HQ | 1 |
| Jayabaskaran, C; Jayakumar, KS; Jiby, MV; Padmesh Pillai, P; Saranya, G | 1 |
| Dántola, ML; Lorente, C; Neyra Recky, JR; Serrano, MP | 1 |
| Blau, N; Burlina, A; Burlina, AP; Cazzorla, C; Giuliani, A; Gragnaniello, V; Gueraldi, D; Hoffmann, G; Opladen, T; Polo, G | 1 |
| Cardoso, R; da S Gonçalves Vianez, JL; de Molfetta, FA; Nahum Alves, C; Santana da Costa, K; Souza da Costa, CH; Valente, R | 1 |
| Jayabaskaran, C; Jayakumar, KS; Jiby, MV; Nair, RA; Pillai, PP; Saranya, G; Sruthi, D | 1 |
| Ho, Y; Hsu, KY; Huang, YJ; Lin, SJ; Tai, L; Uang, YS; Wang, LH | 1 |
| Biswas, S; Das, AK; Ghosh, T; Kori, DKK | 1 |
| Cha, GS; Mok, JA; Park, CM; Yun, CH | 1 |
| Tarasek, D; Wojtasek, H | 1 |
| Chen, Q; Guo, Z; Han, M; Liu, W; Zhang, L | 1 |
| Fan, G; Ge, Q; Hao, S; Lee, SM; Li, L; Liu, X; Qiu, C; Shao, Y; Shi, C; Tang, B; Wu, X | 1 |
| Medeiros, WB; Medina, KJD; Sponchiado, SRP | 1 |
| Karau, A; Pezolt, C; Schobert, R; Schrey, H | 1 |
| Gąsowska-Bajger, B; Wojtasek, H | 1 |
| Chen, L; Kang, Y; Wang, R; Wu, H; Wu, W; Ye, J; Zhang, F; Zhang, H | 1 |
| Guo, X; Liu, H; Luo, Y; Ma, H; Wu, X | 1 |
| Che, D; Dong, J; Gao, P; Huangfu, M; Jiang, W; Yang, T; Zhang, J; Zhang, W | 1 |
| Erbacher, C; Heininen, J; Kostiainen, R; Kotiaho, T; Teppo, J | 1 |
| Bavan, T; Binz, E; Irmler, S; Portmann, R | 1 |
| Kaewjua, K; Siangproh, W | 1 |
10 review(s) available for levodopa and tyrosine
| Article | Year |
|---|---|
Monoamine precursors and analogues.
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; Drug Interactions; Drug Synergism; Humans; Levodopa; Mice; Parkinson Disease; Rats; Receptors, Drug; Stimulation, Chemical; Tremor; Tryptophan; Tyrosine | 1975 |
Noradrenergic influences on dopaminergic function and the pharmacology of dihydroxyphenylserine (DOPS): implication for Parkinson's disease.
Topics: Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Carbidopa; Dopamine; Droxidopa; Levodopa; Locus Coeruleus; Myocardium; Norepinephrine; Pargyline; Parkinson Disease; Serine; Stereoisomerism; Tyrosine | 1985 |
Pharmacokinetics of levodopa.
Topics: Administration, Oral; Age Factors; Amino Acids; Biological Availability; Biological Transport; Biotransformation; Blood-Brain Barrier; Gastric Emptying; Humans; Intestinal Absorption; Kinetics; Levodopa; Methyltyrosines; Time Factors; Tissue Distribution; Tyrosine | 1984 |
Towards defining receptors for L-tyrosine and L-dopa.
Topics: Animals; Cell Membrane; Cell Nucleus; Levodopa; Receptors, Amino Acid; Receptors, Neurotransmitter; Tyrosine | 1994 |
PET tracers for imaging of the dopaminergic system.
Topics: Animals; Brain; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Design; Humans; Levodopa; Ligands; Positron-Emission Tomography; Radioactive Tracers; Receptors, Dopamine; Synaptic Transmission; Tyrosine | 2006 |
[Synthesis of monoamines by non-monoaminergic neurons: illusion or reality?].
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Brain; Corpus Striatum; Dopamine; Humans; Hypothalamus; Levodopa; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Serotonin; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2009 |
Psychiatric implications of endogenous morphine: up-to-date review.
Topics: Animals; Catecholamines; Dopamine; Humans; Leukocytes; Levodopa; Morphine; Morphine Dependence; Mytilus edulis; Nitric Oxide; Opioid Peptides; Signal Transduction; Tyrosine | 2010 |
L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions.
Topics: Animals; Humans; Levodopa; Melanins; Melanocytes; Melanoma; Models, Biological; Monophenol Monooxygenase; Oxidative Stress; Skin Neoplasms; Structure-Activity Relationship; Tyrosine | 2012 |
Activity of selected aromatic amino acids in biological systems.
Topics: Biomarkers; Cardiovascular Diseases; Enzyme Activation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Levodopa; Melanins; Monophenol Monooxygenase; Nervous System Diseases; Oxidative Stress; Renal Insufficiency, Chronic; Serotonin; Tryptophan; Tyrosine | 2011 |
Yeast: A platform for the production of
Topics: Levodopa; Metabolic Engineering; Saccharomyces cerevisiae; Tyrosine | 2023 |
37 trial(s) available for levodopa and tyrosine
| Article | Year |
|---|---|
Tetrahydrobiopterin and Parkinson's disease.
Topics: Adult; Antiparkinson Agents; Benserazide; Biopterins; Clinical Trials as Topic; Drug Combinations; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies.
Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Biological Availability; Carbidopa; Clinical Trials as Topic; Delayed-Action Preparations; Drug Combinations; Fasting; Half-Life; Humans; Intestinal Absorption; Levodopa; Middle Aged; Parkinson Disease; Random Allocation; Reference Values; Tablets; Tyrosine | 1989 |
Controlled-release carbidopa/levodopa (Sinemet 50/200 CR4): clinical and pharmacokinetic studies.
Topics: Aged; Antiparkinson Agents; Carbidopa; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Humans; Levodopa; Middle Aged; Parkinson Disease; Random Allocation; Tyrosine | 1989 |
An open trial of L-tyrosine in the treatment of attention deficit disorder, residual type.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Clinical Trials as Topic; Female; Humans; Levodopa; Male; Middle Aged; Phenylalanine; Psychiatric Status Rating Scales; Tyrosine | 1987 |
Clinical significance of the relationship between O-methyldopa levels and levodopa intake.
Topics: Animals; Carbidopa; Corpus Striatum; Delayed-Action Preparations; Drug Combinations; Female; Humans; Levodopa; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
The pharmacokinetics of intravenous and oral levodopa in patients with Parkinson's disease who exhibit on-off fluctuations.
Topics: Absorption; Administration, Oral; Adult; Carboxy-Lyases; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Half-Life; Humans; Infusions, Intravenous; Kinetics; Levodopa; Male; Middle Aged; Parkinson Disease; Random Allocation; Tyrosine | 1986 |
Human transplacental transfer of carbidopa/levodopa.
Topics: Antiparkinson Agents; Carbidopa; Dopamine; Female; Fetus; Homovanillic Acid; Humans; Levodopa; Maternal-Fetal Exchange; Parkinson Disease; Pregnancy; Tyrosine | 1995 |
Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients.
Topics: Aged; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine Agents; Double-Blind Method; Enzyme Inhibitors; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine | 1996 |
COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers.
Topics: Adult; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Catechols; Cross-Over Studies; Dopamine; Double-Blind Method; Enzyme Inhibitors; Human Growth Hormone; Humans; Levodopa; Male; Nitriles; Placebos; Prolactin; Tyrosine | 1996 |
Clinical drug monitoring by microdialysis: application to levodopa therapy in Parkinson's disease.
Topics: Antiparkinson Agents; Area Under Curve; Drug Monitoring; Half-Life; Humans; Levodopa; Microdialysis; Parkinson Disease; Tyrosine | 1996 |
Effects of tolcapone, a catechol-O-methyltransferase inhibitor, on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Area Under Curve; Benzophenones; Catechol O-Methyltransferase Inhibitors; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 1997 |
Pharmacodynamics of benserazide assessed by its effects on endogenous and exogenous levodopa pharmacokinetics.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Antiparkinson Agents; Benserazide; Carboxy-Lyases; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Levodopa; Male; Middle Aged; Tyrosine | 1997 |
Levodopa and 3-O-methyldopa in cerebrospinal fluid after levodopa-carbidopa association.
Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Chromatography, High Pressure Liquid; Drug Combinations; Electrochemistry; Female; Humans; Levodopa; Male; Middle Aged; Tyrosine | 1997 |
Increase in salsolinol level in the cerebrospinal fluid of parkinsonian patients is related to dementia: advantage of a new high-performance liquid chromatography methodology.
Topics: Adult; Aged; Antiparkinson Agents; Chromatography, High Pressure Liquid; Dementia; Female; Homovanillic Acid; Humans; Isoquinolines; Levodopa; Male; Middle Aged; Parkinson Disease; Psychiatric Status Rating Scales; Tyrosine | 1997 |
Pharmacokinetic studies with a dual-release formulation of levodopa, a novel principle in the treatment of Parkinson's disease.
Topics: Adolescent; Adult; Antiparkinson Agents; Cross-Over Studies; Delayed-Action Preparations; Female; Food; Humans; Levodopa; Male; Parkinson Disease; Tablets; Tyrosine | 1998 |
Comparative single- and multiple-dose pharmacokinetics of levodopa and 3-O-methyldopa following a new dual-release and a conventional slow-release formulation of levodopa and benserazide in healthy subjects.
Topics: Benserazide; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Fasting; Humans; Levodopa; Metabolic Clearance Rate; Time Factors; Tyrosine | 1998 |
The effect of tolcapone on the pharmacokinetics of benserazide.
Topics: Aged; Antiparkinson Agents; Benserazide; Benzophenones; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Hydrazines; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Time Factors; Tolcapone; Tyrosine | 1999 |
Pharmacodynamic modelling of levodopa, 3-O-methyldopa and their effects: an application of the Dixon equation.
Topics: Aged; Drug Interactions; Female; Humans; Levodopa; Male; Models, Statistical; Parkinson Disease; Tyrosine | 1999 |
Peripheral markers of oxidative stress in Parkinson's disease. The role of L-DOPA.
Topics: Antiparkinson Agents; Biomarkers; Blood Platelets; Dopamine; Female; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; In Vitro Techniques; Levodopa; Linear Models; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Sodium Salicylate; Superoxide Dismutase; Tyrosine | 1999 |
Determination of hydroxyl free radical formation in human platelets using high-performance liquid chromatography with electrochemical detection.
Topics: Adult; Antiparkinson Agents; Blood Platelets; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Hydroxybenzoates; Hydroxyl Radical; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1999 |
Effects of food on the pharmacokinetics of levodopa in a dual-release formulation.
Topics: Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Fasting; Female; Food; Food-Drug Interactions; Half-Life; Humans; Levodopa; Male; Time Factors; Tyrosine | 2003 |
The phenylalanine loading test in the differential diagnosis of dystonia.
Topics: Administration, Oral; Adult; Diagnosis, Differential; Dystonia; Female; Humans; Levodopa; Male; Middle Aged; Phenylalanine; Predictive Value of Tests; Reference Values; Sensitivity and Specificity; Time Factors; Tyrosine | 2003 |
Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide.
Topics: Acetophenones; Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Catechol O-Methyltransferase Inhibitors; Cross-Over Studies; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Tyrosine | 2003 |
Chronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's disease.
Topics: Adult; Aged; Analysis of Variance; Antiparkinson Agents; Area Under Curve; Benserazide; Biological Availability; Dihydroxyphenylalanine; Drug Administration Routes; Drug Administration Schedule; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Time Factors; Tyrosine | 2004 |
Cocaine craving, euphoria, and self-administration: a preliminary study of the effect of catecholamine precursor depletion.
Topics: Adult; Catecholamines; Circadian Rhythm; Cocaine; Cocaine-Related Disorders; Diet, Protein-Restricted; Dopamine Agents; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Euphoria; Humans; Levodopa; Male; Phenylalanine; Self Administration; Time Factors; Tyrosine | 2005 |
Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers.
Topics: Adult; Diet, Protein-Restricted; Dopamine; Dopamine Agents; Humans; Levodopa; Male; Pain Measurement; Phenylalanine; Self Administration; Surveys and Questionnaires; Time Factors; Tobacco Use Disorder; Tyrosine | 2006 |
Pharmacokinetic behaviour of levodopa and 3-O-methyldopa after repeat administration of levodopa/carbidopa with and without entacapone in patients with Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Area Under Curve; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Female; Humans; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Parkinson Disease; Tyrosine | 2006 |
Acute levodopa administration reduces cortisol release in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Benserazide; Down-Regulation; Enzyme Inhibitors; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Levodopa; Male; Middle Aged; Neural Pathways; Parkinson Disease; Raphe Nuclei; Serotonin; Tyrosine | 2007 |
Mood-elevating effects of d-amphetamine and incentive salience: the effect of acute dopamine precursor depletion.
Topics: Adult; Affect; Attention; Carbidopa; Central Nervous System Stimulants; Dextroamphetamine; Dopamine; Double-Blind Method; Drug Combinations; Humans; Levodopa; Male; Motivation; Neuropsychological Tests; Pain Measurement; Phenylalanine; Reaction Time; Tyrosine | 2007 |
Comparison of 200 mg retarded release levodopa/carbidopa - with 150 mg levodopa/carbidopa/entacapone application: pharmacokinetics and efficacy in patients with Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Carbidopa; Catechols; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine | 2007 |
The role of dopamine in alcohol self-administration in humans: individual differences.
Topics: Adult; Alcohol Drinking; Amino Acids; Analysis of Variance; Dopamine; Dopamine Agents; Double-Blind Method; Ethanol; Heart Rate; Humans; Individuality; Levodopa; Male; Phenylalanine; Self Administration; Tyrosine | 2008 |
Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor, and controlled-release levodopa/carbidopa 200 mg/50 mg : randomized, double-blind, placebo-controlled, crossover study in healthy subjects.
Topics: Acetophenones; Adult; Antiparkinson Agents; Area Under Curve; Carbidopa; Catechol O-Methyltransferase Inhibitors; Cross-Over Studies; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Humans; Levodopa; Male; Time Factors; Tyrosine; Young Adult | 2008 |
Homocysteine levels after acute levodopa intake in patients with Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Dihydroxyphenylalanine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Severity of Illness Index; Statistics as Topic; Time Factors; Tyrosine | 2009 |
Pharmacokinetic-pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide: a single-center, Phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects.
Topics: Acetophenones; Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Tyrosine; Young Adult | 2009 |
Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease.
Topics: Age of Onset; Aged; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Drug Combinations; Drug Therapy, Combination; Dyskinesias; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Nitrophenols; Parkinson Disease; Severity of Illness Index; Tolcapone; Tyrosine | 2010 |
Inhibition of catechol-O-methyltransferase modifies acute homocysteine rise during repeated levodopa application in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Biological Availability; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Combinations; Drug Therapy, Combination; Female; Half-Life; Homocysteine; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine | 2011 |
Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Benzophenones; Catechols; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Nitrophenols; Parkinson Disease; Pilot Projects; Self Report; Single-Blind Method; Sweden; Tolcapone; Tyrosine | 2012 |
389 other study(ies) available for levodopa and tyrosine
| Article | Year |
|---|---|
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location.
Topics: Amino Acid Sequence; Amino Acid Transport Systems, Neutral; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 6; Humans; Molecular Sequence Data; Oocytes; Rats; Sequence Analysis, DNA; Sequence Homology; Xenopus laevis | 2002 |
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
Topics: Amines; Amino Acids; Carbonic Anhydrases; Catalysis; Enzyme Activation; Humans; Kinetics; Mitochondrial Proteins; Protein Isoforms; Structure-Activity Relationship | 2007 |
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
Topics: Amines; Amino Acid Sequence; Amino Acids; Carbonic Anhydrases; Cloning, Molecular; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; Molecular Sequence Data; Protein Isoforms; Protein Subunits | 2007 |
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
Topics: Amines; Amino Acid Sequence; Amino Acids; Carbonic Anhydrases; Enzyme Activation; Enzyme Activators; Humans; Isoenzymes; Molecular Sequence Data; Sequence Homology, Amino Acid | 2007 |
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
Topics: Amines; Amino Acids; Antigens, Neoplasm; Carbonic Anhydrase IX; Carbonic Anhydrases; Conserved Sequence; Enzyme Activation; Humans; Isoenzymes; Kinetics; Molecular Sequence Data; Molecular Structure; Neoplasms; Sequence Alignment; Structure-Activity Relationship | 2008 |
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
Topics: Amines; Amino Acids; Binding Sites; Carbonic Anhydrase III; Carbonic Anhydrase IV; Cell Membrane; Cytosol; Enzyme Activation; Histidine; Humans; Isoenzymes; Molecular Structure; Morpholines; Serotonin; Stereoisomerism | 2008 |
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
Topics: Amines; Amino Acids; Archaea; Carbonic Anhydrases; Catalysis; Molecular Structure; Phenylalanine; Stereoisomerism; Tyrosine | 2008 |
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
Topics: Amino Acids; Candida albicans; Carbonic Anhydrases; Catalysis; Catalytic Domain; Cryptococcus neoformans; Drug Design; Enzyme Activation; Epinephrine; Humans; Kinetics; Models, Chemical; Protein Isoforms; Saccharomyces cerevisiae; Tryptophan | 2009 |
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
Topics: Amines; Amino Acid Sequence; Amino Acids; Animals; Carbonic Anhydrases; Enzyme Activators; Humans; Kinetics; Mice; Molecular Sequence Data; Protein Isoforms; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2009 |
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.
Topics: Amines; Amino Acids; Candida albicans; Carbonic Anhydrase I; Carbonic Anhydrases; Cryptococcus neoformans; Enzyme Activation; Structure-Activity Relationship | 2010 |
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
Topics: Amines; Amino Acids; Candida glabrata; Carbonic Anhydrases; Catalytic Domain; Enzyme Activation; Humans; Kinetics; Models, Molecular; Recombinant Proteins; Structure-Activity Relationship | 2010 |
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
Topics: Amines; Amino Acids; Animals; Anthozoa; Carbonic Anhydrases; Enzyme Activation; Humans; Isoenzymes; Kinetics; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2010 |
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
Topics: Amines; Amino Acids; Carbon Dioxide; Carbonic Anhydrases; Enzyme Activation; Gram-Negative Chemolithotrophic Bacteria; Kinetics | 2012 |
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
Topics: Amines; Amino Acids; Bacteria; Carbonic Anhydrases; Catalysis; Structure-Activity Relationship; Sulfur Compounds | 2013 |
Evaluation of scavenging rate constants of DOPA and tyrosine enantiomers against multiple reactive oxygen species and methyl radical as measured with ESR trapping method.
Topics: Dihydroxyphenylalanine; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Kinetics; Levodopa; Methane; Reactive Oxygen Species; Spin Trapping; Stereoisomerism; Tyrosine | 2015 |
Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from Malassezia globosa with amines and amino acids.
Topics: Amines; Amino Acids; Antifungal Agents; Carbonic Anhydrases; Dandruff; Dose-Response Relationship, Drug; Ligands; Malassezia; Molecular Structure; Structure-Activity Relationship | 2016 |
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
Topics: Amines; Amino Acids; Burkholderia pseudomallei; Carbonic Anhydrases; Dose-Response Relationship, Drug; Humans; Molecular Structure; Structure-Activity Relationship | 2017 |
On the specificity and mechanism of action of m-tyrosine in antagonizing the central effects of reserpine in rats.
Topics: Animals; Brain; Brain Chemistry; Corpus Striatum; Dopamine; In Vitro Techniques; Levodopa; Male; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains; Reserpine; Stimulation, Chemical; Time Factors; Tyrosine | 1976 |
Amino acid precursors of monoamine neurotransmitters and some factors influencing their supply to the brain.
Topics: Amino Acids, Essential; Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Carbon Radioisotopes; Histidine; Levodopa; Neurotransmitter Agents; Osmolar Concentration; Phenylalanine; Protein Precursors; Rats; Tryptophan; Tyrosine | 1976 |
Neurochemical changes following the administration of precursors of biogenic amines.
Topics: 5-Hydroxytryptophan; Acetylcholine; Amino Acids; Animals; Brain; Choline; Dopamine; gamma-Aminobutyric Acid; Levodopa; Male; Neurotransmitter Agents; Norepinephrine; Rats; Serotonin; Tryptophan; Tyrosine | 1977 |
Biogenic amine synthesis defect in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Amines; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Intellectual Disability; Levodopa; Male; NADH, NADPH Oxidoreductases; Neurotransmitter Agents; Phenylketonurias; Probenecid; Seizures; Serotonin; Tyrosine | 1977 |
Evidence for inhibition of dopamine-beta-hydroxylase in vivo after sub-acute pyrazole treatment in rats.
Topics: Animals; Brain; Disulfiram; Dopamine; Dopamine beta-Hydroxylase; Hypothalamus; Levodopa; Male; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Piperazines; Pyrazoles; Rats; Reserpine; Serotonin; Tyrosine | 1977 |
Malignant pheochromocytoma. Effect of oral alpha-methyl-p-tyrosine upon catecholamine metabolism.
Topics: Administration, Oral; Adrenal Gland Neoplasms; Adult; Catecholamines; Humans; Levodopa; Long-Term Care; Male; Norepinephrine; Pheochromocytoma; Tyrosine | 1979 |
Modification of spontaneous ECoG and behavior in cat by monoamine precursors.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Biogenic Amines; Cats; Electroencephalography; Levodopa; Sleep; Tryptophan; Tyrosine | 1979 |
[Relationship between biogenic amines and analgesic action of difenamizole in heat induced reflexes].
Topics: 5-Hydroxytryptophan; Aminopyrine; Analgesics; Animals; Biogenic Amines; Brain Chemistry; Drug Synergism; Fenclonine; Levodopa; Male; Mice; Morphine; Pyrazoles; Rats; Reflex; Reserpine; Serotonin; Tyrosine | 1976 |
[The effect of various amines on TRH contents in rat brain (author's transl)].
Topics: 5-Hydroxytryptophan; Amines; Animals; Brain Chemistry; Fenclonine; Fusaric Acid; Levodopa; Male; Methods; Radioimmunoassay; Rats; Reserpine; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine; Tyrosine | 1976 |
Action of dopamine agonists on parkinson-like muscle rigidity induced by 6-aminonicotinamide.
Topics: 6-Aminonicotinamide; Animals; Brain Chemistry; Corpus Striatum; Diencephalon; Dihydroxyphenylalanine; Electromyography; Levodopa; Limbic System; Lisuride; Male; Muscles; Niacinamide; Parkinson Disease, Secondary; Rats; Tyrosine | 1979 |
Sleep and behavioral changes possibly reflecting central receptor hypersensitivity following catecholamine synthesis inhibition in man.
Topics: Behavior; Bipolar Disorder; Dopamine; Humans; Levodopa; Norepinephrine; Receptors, Neurotransmitter; Sleep; Substance Withdrawal Syndrome; Tryptophan; Tyrosine | 1977 |
Studies on the synthesis and subcellular distribution of dopamine in the rat adrenal medulla.
Topics: Adrenal Medulla; Animals; Cell Fractionation; Dopamine; Epinephrine; Levodopa; Male; Norepinephrine; Rats; Time Factors; Tritium; Tyrosine; Tyrosine 3-Monooxygenase | 1975 |
Amphetamine-induced inhibition of tyrosine hydroxylation in homogenates of rat corpus striatum.
Topics: Amphetamine; Animals; Corpus Striatum; In Vitro Techniques; Levodopa; Male; Nerve Endings; Rats; Receptors, Drug; Synaptosomes; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 1975 |
Interaction of N-(DL-seryl)N'-(2,3,4-trihydroxybenzyl)-hydrazine with L-dopa decarboxylase from pig kidney.
Topics: 5-Hydroxytryptophan; Animals; Benserazide; Dopa Decarboxylase; Hydrazines; Kidney; Kinetics; Levodopa; Protein Binding; Spectrophotometry; Spectrophotometry, Ultraviolet; Swine; Tyrosine | 1977 |
Theoretical and therapeutic potential of indolamine precursors in affective disorders.
Topics: 5-Hydroxytryptophan; Amino Acids; Bipolar Disorder; Depression; Emotions; Female; Humans; Levodopa; Male; Phenylalanine; Serotonin; Sex Factors; Tryptophan; Tyrosine | 1977 |
Substrate specificity and other properties of DOPA decarboxylase from guinea pig kidneys.
Topics: 5-Hydroxytryptophan; Animals; Dopa Decarboxylase; Guinea Pigs; Kidney; Levodopa; Pyridoxal Phosphate; Substrate Specificity; Tyrosine | 1978 |
Effect of alpha-MSH on the tyrosinase activity and the rate of melanin accumulation of melanoma cells in vitro.
Topics: Animals; Catechol Oxidase; Cells, Cultured; In Vitro Techniques; Levodopa; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Mice; Monophenol Monooxygenase; Neoplasms, Experimental; Puromycin; Tyrosine | 1977 |
Phenol oxidase activity: inductionin female schistosomes by in vitro incubation.
Topics: Animals; Catechol Oxidase; Dopamine; Enzyme Induction; Female; Levodopa; Male; Schistosoma mansoni; Tyrosine | 1978 |
New procedure for isolation of amino acids based on selective hydrolysis of trimethylsilyl derivatives.
Topics: Amino Acids; Gas Chromatography-Mass Spectrometry; Humans; Levodopa; Methyldopa; Trimethylsilyl Compounds; Tyrosine | 1979 |
Methoxytyrosine formation as an indicator of catechol-O-methyltransferase activity in rat liver in vivo.
Topics: Amino Acids; Animals; Carboxy-Lyases; Catechol O-Methyltransferase; Hydrazines; Levodopa; Liver; Male; Rats; Time Factors; Tyrosine | 1977 |
Hypokinesia produced by anterolateral hypothalamic 6-hydroxydopamine lesions and its reversal by some antiparkinson drugs.
Topics: Animals; Antiparkinson Agents; Apomorphine; Brain; Bromocriptine; Dopamine; Hydroxydopamines; Hypothalamus; Hypothalamus, Anterior; Levodopa; Male; Models, Neurological; Motor Activity; Norepinephrine; Piribedil; Rats; Receptors, Dopamine; Serotonin; Tyrosine | 1978 |
Biochemical evidence for the presence of presynaptic receptors on dopaminergic nerve terminals.
Topics: Acetylcholine; Animals; Bungarotoxins; Corpus Striatum; Dopamine; Haloperidol; In Vitro Techniques; Levodopa; Potassium; Receptors, Dopamine; Receptors, Nicotinic; Sheep; Synaptosomes; Tyrosine | 1978 |
Dopaminergic agonists in animal models of parkinsonism.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Cats; Disease Models, Animal; Haplorhini; Levodopa; Parkinson Disease, Secondary; Piribedil; Rats; Reserpine; Tyrosine | 1975 |
Mammalian tyrosinase. A comparison of tyrosine hydroxylation and melanin formation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Binding Sites; Catechol Oxidase; Dihydroxyphenylalanine; Dopamine; Kinetics; Levodopa; Melanins; Melanocytes; Mice; Monophenol Monooxygenase; Time Factors; Tyrosine | 1976 |
Selective incorporation of L-3,4-dihydroxyphenylalanine by S-91 Cloudman melanoma in vitro.
Topics: Cells, Cultured; Cycloheximide; Levodopa; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Neoplasms, Experimental; Theophylline; Tyrosine | 1977 |
Reinstatement of vaginal cycles in aged female rats.
Topics: Aging; Animals; Benserazide; Carbidopa; Dose-Response Relationship, Drug; Drug Interactions; Estrus; Female; Fusaric Acid; Hypophysectomy; Levodopa; Phenoxybenzamine; Pimozide; Pregnancy; Propranolol; Rats; Tyrosine; Vagina | 1976 |
[Effect of halothane on catecholamine metabolism in the brain stem of rats].
Topics: Animals; Brain Stem; Catecholamines; Dopamine; Halothane; Levodopa; Male; Norepinephrine; Rats; Sympathetic Nervous System; Tyrosine | 1976 |
The metabolism of tyrosine, tyramine and L-3,4-dihydroxyphenylalanine by cerebral and thoracic ganglia of the locust, Schistocerca gregaria.
Topics: Animals; Brain; Ganglia; Grasshoppers; Levodopa; Spinal Cord; Tyramine; Tyrosine | 1976 |
[Endogenous catecholamines and excitability of the superior cervical ganglion of the rat (author's transl)].
Topics: Animals; Benserazide; Catecholamines; Chromaffin System; Ganglia, Autonomic; Guanethidine; Iproniazid; Levodopa; Male; Rats; Rats, Inbred Strains; Reserpine; Tyrosine | 1976 |
Comparison of short and long-lasting effects of pargyline on cerebral dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cisterna Magna; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Injections; Injections, Intravenous; Levodopa; Methyldopa; Monoamine Oxidase; Pargyline; Rats; Time Factors; Tyrosine | 1976 |
Influence of L-3-methoxytyrosine on monoamine synthesis in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Brain; Dihydroxyphenylalanine; Dopamine; Hydrazines; Hydroxyindoleacetic Acid; Levodopa; Liver; Male; Myocardium; Norepinephrine; Rats; Serotonin; Tryptophan; Tyrosine | 1975 |
[Hypothetical concept: the physiopathological entity of monoaminergic psychoses].
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Behavior, Animal; Bipolar Disorder; Blood-Brain Barrier; Catecholamines; Diet; Humans; Levodopa; Neurons; Rats; Schizophrenia; Serotonin; Sexual Behavior; Tryptophan; Tyrosine | 1975 |
Metatyramine as a dopaminergic agonist.
Topics: 3-Methoxy-4-hydroxyphenylethanol; Animals; Dopamine; Drug Interactions; Exploratory Behavior; Homovanillic Acid; Levodopa; Motor Activity; Phenylacetates; Rats; Receptors, Drug; Reserpine; Tyramine; Tyrosine | 1975 |
Aging and the passage of L-tyrosine, L-DOPA, and inulin into mouse brain slices in vitro.
Topics: Aging; Animals; Biological Transport, Active; Brain; Brain Stem; Corpus Striatum; Hypothalamus; In Vitro Techniques; Inulin; Levodopa; Male; Mice; Mice, Inbred C57BL; Tritium; Tyrosine | 1975 |
Proceedings: Methoxytyrosine formation as in indicator of catechol-O-methyltransferase activity in rats in vivo.
Topics: Animals; Catechol O-Methyltransferase; Levodopa; Methyl Ethers; Rats; Tyrosine | 1975 |
Dopaminergic supersensitivity in parkinsonism.
Topics: Aged; Benzyl Compounds; Brain; Brain Chemistry; Dopamine; Drug Therapy, Combination; Female; Humans; Hydrazines; Hydroxyindoleacetic Acid; Levodopa; Nerve Degeneration; Norepinephrine; Parkinson Disease; Psychoses, Substance-Induced; Serotonin; Tryptophan; Tyrosine | 1975 |
Actions of dopaminergic agonists on motor function.
Topics: Amantadine; Animals; Apomorphine; Behavior; Dextroamphetamine; Disease Models, Animal; Dopamine Antagonists; Humans; Hyperkinesis; Levodopa; Methylphenidate; Motor Activity; Movement Disorders; Phenethylamines; Piribedil; Rats; Stereotyped Behavior; Tyrosine | 1975 |
Behavioral correlates of dopaminergic supersensitivity.
Topics: Animals; Animals, Newborn; Apomorphine; Behavior; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxydopamines; Hypothalamus; Levodopa; Motor Activity; Nerve Degeneration; Rats; Receptors, Drug; Stereotyped Behavior; Substantia Nigra; Tranylcypromine; Tyrosine | 1975 |
General pharmacological actions of N-acetoacetyl-3-hydroxytyrosine.
Topics: Acetoacetates; Analgesics; Animals; Anticonvulsants; Anura; Blood Pressure; Body Temperature; Female; Guinea Pigs; In Vitro Techniques; Levodopa; Male; Mice; Motor Activity; Muscle Contraction; Muscle, Smooth; Muscles; Rats; Sleep; Tyrosine | 1975 |
[Mechanisms of catecholamine synthesis disorders in the adrenals of rats subjected to physical fatigue].
Topics: Adrenal Glands; Animals; Catecholamines; Dopamine; Epinephrine; Fatigue; Levodopa; Male; Norepinephrine; Rats; Tyrosine | 1975 |
Modification of the actions of some neuroactive drugs by growth hormone.
Topics: Animals; Apomorphine; Behavior, Animal; Dihydroxyphenylalanine; Dopamine; Drug Synergism; Growth Hormone; Levodopa; Male; Mice; Oxotremorine; Parkinson Disease; Psychotropic Drugs; Tyrosine | 1976 |
Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology.
Topics: 5-Hydroxytryptophan; Aromatic-L-Amino-Acid Decarboxylases; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dopa Decarboxylase; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Levodopa; Liver; Metabolism, Inborn Errors; Reference Values; Tyrosine | 1992 |
Beta-adrenergic regulation of amine precursor amino acid transport across the blood-brain barrier.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Amino Acids; Animals; Biogenic Amines; Blood-Brain Barrier; Brain Chemistry; Dopamine; In Vitro Techniques; Isoproterenol; Levodopa; Male; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Tyrosine | 1992 |
The mechanism of perturbation in monoamine metabolism by L-dopa therapy: in vivo and in vitro studies.
Topics: Aged; Amino Acids; Animals; Biogenic Monoamines; Corpus Striatum; Dialysis; Dopamine; Female; Humans; In Vitro Techniques; Kinetics; Levodopa; Male; Middle Aged; Neurons; Parkinson Disease; PC12 Cells; Rats; Tryptophan Hydroxylase; Tyrosine; Tyrosine 3-Monooxygenase | 1992 |
Truffle melanogenesis: correlation with reproductive differentiation and ascocarp ripening.
Topics: Fungi; Histocytochemistry; Levodopa; Melanins; Monophenol Monooxygenase; Tyrosine; Tyrosine 3-Monooxygenase | 1992 |
Biochemical and functional differences between dopamine formed from endogenous tyrosine and exogenous L-dopa in nigrostriatal dopaminergic neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Levodopa; Male; Neurons; Rats; Reserpine; Substantia Nigra; Tyrosine | 1992 |
Assessment of dopamine and its metabolites in the intracellular and extracellular compartments of the rat striatum after peripheral administration of L-[11C]dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Extracellular Space; Homovanillic Acid; Injections, Intravenous; Intracellular Fluid; Kinetics; Levodopa; Male; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
Oxidative ring-coupling of tyrosine and its derivatives by purified rat intestinal peroxidase.
Topics: alpha-Methyltyrosine; Amphetamine; Animals; Hydrogen Peroxide; Intestines; Kinetics; Levodopa; Mass Spectrometry; Methyltyrosines; Oxidation-Reduction; Peroxidases; Rats; Tyramine; Tyrosine | 1992 |
Effects of systemic carbidopa on dopamine synthesis in rat hypothalamus and striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Corpus Striatum; Depression, Chemical; Dialysis; Dopamine; Homovanillic Acid; Hypothalamus; Injections, Intraperitoneal; Levodopa; Male; Perfusion; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
Multi-enzymatic syntheses of L-tyrosine and L-DOPA. 11C labeling in two positions.
Topics: Carbon Radioisotopes; Isotope Labeling; Levodopa; Tyrosine | 1991 |
Peripheral pharmacokinetic handling and metabolism of L-dopa in the rat: the effect of route of administration and carbidopa pretreatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Aorta, Thoracic; Carbidopa; Chromatography, High Pressure Liquid; Homovanillic Acid; Injections, Intravenous; Levodopa; Male; Rats; Rats, Inbred Strains; Tyrosine | 1991 |
The significance of 3-O-methyldopa concentrations in the cerebrospinal fluid in the pathogenesis of wearing-off phenomenon in Parkinson's disease.
Topics: Biogenic Monoamines; Biomarkers; Carbidopa; Humans; Levodopa; Middle Aged; Parkinson Disease; Tyrosine | 1991 |
In vivo pharmacokinetics of levodopa and 3-O-methyldopa in muscle. A microdialysis study.
Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Dialysis; Dogs; Injections, Intravenous; Levodopa; Male; Muscles; Tyrosine | 1991 |
Continuous intravenous monitoring of levodopa and 3-O-methyldopa by microdialysis and high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Dialysis; Dogs; Electrochemistry; Levodopa; Male; Microchemistry; Reference Standards; Regression Analysis; Tyrosine | 1991 |
Simultaneous determination of levodopa, its main metabolites and carbidopa in plasma by liquid chromatography.
Topics: 3,4-Dihydroxyphenylacetic Acid; Carbidopa; Chromatography, High Pressure Liquid; Chromatography, Liquid; Freeze Drying; Homovanillic Acid; Humans; Hydrogen-Ion Concentration; Levodopa; Solutions; Tyrosine | 1991 |
Reduction of circulating 3-O-methyldopa by inhibition of catechol-O-methyltransferase with OR-611 and OR-462 in cynomolgus monkeys: implications for the treatment of Parkinson's disease.
Topics: Animals; Catechol O-Methyltransferase Inhibitors; Catechols; Levodopa; Macaca fascicularis; Male; Nitriles; Parkinson Disease; Pentanones; Tyrosine | 1991 |
L-tyrosine-binding proteins on melanoma cells.
Topics: Animals; Antibodies; Blotting, Western; Carbon Radioisotopes; Chromatography, Affinity; Cricetinae; Levodopa; Melanoma; Molecular Weight; Monophenol Monooxygenase; Phenylalanine; Protein Binding; Tumor Cells, Cultured; Tyrosine | 1991 |
POMC gene expression in mouse and hamster melanoma cells.
Topics: Animals; Blotting, Northern; Cell Line; Cricetinae; Gene Expression Regulation, Neoplastic; Levodopa; Male; Melanoma, Experimental; Mesocricetus; Mice; Neoplasm Transplantation; Pro-Opiomelanocortin; Tumor Cells, Cultured; Tyrosine | 1991 |
Effects of dietary tyrosine on L-dopa- and amphetamine-induced changes in locomotor activity and neurochemistry in mice.
Topics: Animals; Biogenic Monoamines; Body Weight; Brain Chemistry; Dextroamphetamine; Diet; Drug Interactions; Levodopa; Male; Mice; Motor Activity; Phenylalanine; Tyrosine | 1990 |
Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues.
Topics: Animals; Benserazide; Benzophenones; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Electrochemistry; Erythrocytes; Half-Life; In Vitro Techniques; Levodopa; Male; Nitrophenols; Norepinephrine; Rats; Rats, Inbred Strains; Tolcapone; Tyrosine | 1990 |
Simultaneous high-performance liquid chromatographic analysis of carbidopa, levodopa and 3-O-methyldopa in plasma and carbidopa, levodopa and dopamine in urine using electrochemical detection.
Topics: Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Humans; Levodopa; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 1990 |
Production of L-dopa by Aspergillus terreus.
Topics: Antioxidants; Ascorbic Acid; Aspergillus; Culture Media; Kinetics; Levodopa; Monophenol Monooxygenase; Substrate Specificity; Tyrosine | 1990 |
Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-dopa in the rat.
Topics: Amidines; Animals; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Electrochemistry; Female; Homovanillic Acid; Levodopa; Pyridones; Rats; Rats, Inbred Strains; Tyrosine | 1990 |
Synthesis of radiofluorinated analogs of m-tyrosine as potential L-dopa tracers via direct reaction with acetylhypofluorite.
Topics: Brain; Fluorine Radioisotopes; Humans; Isotope Labeling; Levodopa; Tomography, Emission-Computed; Tyrosine | 1990 |
Effect of precursors on the synthesis of catecholamines and on neurotransmission in the superior cervical ganglion of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Action Potentials; Animals; Aspartame; Catecholamines; Dipeptides; Dopamine; Electric Stimulation; Ganglia, Sympathetic; Levodopa; Male; Nialamide; Norepinephrine; Rats; Rats, Inbred Strains; Synaptic Transmission; Tyrosine | 1990 |
Fast enzymatic preparation of L-dopa from tyrosine and molecular oxygen: a potential method for preparing [15O]L-dopa.
Topics: Levodopa; Monophenol Monooxygenase; Oxygen Radioisotopes; Tomography, Emission-Computed; Tyrosine | 1990 |
Endogenous mutagens derived from amino acids.
Topics: Acetylcysteine; Amino Acids; Animals; Cells, Cultured; Homogentisic Acid; Levodopa; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Tyrosine | 1990 |
Interference of 3-O-methyldopa with L-dopa treatment for MPTP-induced parkinsonism in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Injections, Intravenous; Levodopa; Male; Mice; Mice, Inbred C57BL; Parkinson Disease, Secondary; Receptors, Dopamine; Tyrosine | 1990 |
Effect of nitecapone (OR-462) on the pharmacokinetics of levodopa and 3-O-methyldopa formation in cynomolgus monkeys.
Topics: Animals; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Levodopa; Macaca fascicularis; Male; Pentanones; Tyrosine | 1990 |
Are L-tyrosine and L-dopa hormone-like bioregulators?
Topics: Animals; Hormones; Levodopa; Mammals; Melanocytes; Models, Biological; Pigmentation; Tyrosine | 1990 |
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans.
Topics: Adolescent; Akinetic Mutism; Biopterins; Child, Preschool; Humans; Infant; Levodopa; Methionine; NADH, NADPH Oxidoreductases; Phenylketonurias; Pyridoxine; S-Adenosylmethionine; Tetrahydrofolates; Tyrosine | 1990 |
L-tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells.
Topics: Animals; Catechol Oxidase; Cricetinae; Enzyme Induction; Kinetics; Levodopa; Melanocyte-Stimulating Hormones; Melanoma, Experimental; Monophenol Monooxygenase; Receptors, Pituitary Hormone; Tumor Cells, Cultured; Tyrosine | 1989 |
A pharmacokinetic and pharmacodynamic comparison of Sinemet CR (50/200) and standard Sinemet (25/100).
Topics: Antiparkinson Agents; Carbidopa; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
[Effect of ethanol and probenecid on the excretory function of the cerebral choroid plexus in rats].
Topics: Animals; Carbon Radioisotopes; Choroid Plexus; Dose-Response Relationship, Drug; Ethanol; Levodopa; Male; Probenecid; Rats; Rats, Inbred Strains; Time Factors; Tryptophan; Tyrosine | 1989 |
Levodopa and 3-O-methyldopa plasma levels in parkinsonian patients with stable and fluctuating motor response.
Topics: Aged; Carbidopa; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
Increased dosage of carbidopa in parkinsonian patients on low carbidopa-levodopa regimen. Effect on levodopa bioavailability.
Topics: Aged; Aged, 80 and over; Biological Availability; Carbidopa; Dose-Response Relationship, Drug; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
Kinetic study of catecholamine metabolism in hereditary progressive dystonia.
Topics: Adolescent; Catecholamines; Child; Dystonia; Female; Humans; Levodopa; Tyrosine | 1989 |
Treatment of idiopathic parkinsonism with L-dopa in the absence and presence of decarboxylase inhibitors: effects on plasma levels of L-dopa, dopa decarboxylase, catecholamines and 3-O-methyl-dopa.
Topics: Administration, Oral; Aged; Benserazide; Carboxy-Lyases; Catecholamines; Dopa Decarboxylase; Drug Combinations; Drug Therapy, Combination; Female; Humans; Levodopa; Longitudinal Studies; Male; Middle Aged; Parkinson Disease; Phenytoin; Time Factors; Tyrosine | 1989 |
A new potential prodrug to improve the duration of L-dopa: L-3-(3-hydroxy-4-pivaloyloxyphenyl)alanine.
Topics: Animals; Biological Availability; Carbidopa; Chromatography, High Pressure Liquid; Dogs; Levodopa; Male; Prodrugs; Rats; Rats, Inbred Strains; Tyrosine | 1989 |
Re-evaluation of the L-dopa loading effect on dopamine metabolism in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Therapy, Combination; Homovanillic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Tyrosine | 1986 |
Assay for tyrosine hydroxylase by high-performance liquid chromatography with fluorescence detection.
Topics: Adrenal Medulla; Animals; Brain; Brain Chemistry; Catalase; Chromatography, High Pressure Liquid; Iron; Levodopa; Male; Phenylalanine; Rats; Spectrometry, Fluorescence; Tyrosine; Tyrosine 3-Monooxygenase | 1987 |
Simple assay procedure for tyrosine hydroxylase activity by high-performance liquid chromatography employing coulometric detection with minimal sample preparation.
Topics: Adrenal Gland Neoplasms; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Clone Cells; Electrochemistry; Humans; Levodopa; Nerve Tissue Proteins; Pheochromocytoma; Synaptosomes; Tumor Cells, Cultured; Tyrosine; Tyrosine 3-Monooxygenase | 1988 |
Investigation of dopamine content, synthesis, and release in the rabbit retina in vitro: I. Effects of dopamine precursors, reserpine, amphetamine, and L-DOPA decarboxylase and monoamine oxidase inhibitors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Dopamine; Female; Levodopa; Male; Monoamine Oxidase Inhibitors; Pargyline; Rabbits; Reserpine; Retina; Selegiline; Tyrosine | 1986 |
Effects of 5-hydroxytryptamine, dopamine, and aromatic L-amino acids on growth hormone (GH)-releasing factor-stimulated GH release in rat anterior pituitaries.
Topics: Animals; Benserazide; Carbidopa; Dopamine; Growth Hormone; Growth Hormone-Releasing Hormone; In Vitro Techniques; Kinetics; Levodopa; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Serotonin; Tyrosine | 1987 |
A kinetic study of the melanization pathway between L-tyrosine and dopachrome.
Topics: Animals; Epidermis; Hydrogen-Ion Concentration; Hydroxylation; Indolequinones; Indoles; Kinetics; Levodopa; Melanins; Models, Biological; Monophenol Monooxygenase; Quinones; Rana esculenta; Tyrosine | 1987 |
Inhibition of decarboxylase and levels of dopa and 3-O-methyldopa: a comparative study of benserazide versus carbidopa in rodents and of Madopar standard versus Madopar HBS in volunteers.
Topics: Administration, Oral; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Brain; Carbidopa; Delayed-Action Preparations; Dihydroxyphenylalanine; Dogs; Dopa Decarboxylase; Dose-Response Relationship, Drug; Drug Combinations; Humans; Hydrazines; Kidney; Levodopa; Liver; Male; Mice; Rats; Time Factors; Tyrosine | 1987 |
A possible role for melanin precursors in regulating both pigmentation and proliferation of melanocytes.
Topics: Animals; Cell Division; Levodopa; Melanins; Melanocytes; Monophenol Monooxygenase; Pigments, Biological; Protein Precursors; Tyrosine | 1988 |
MSH binding in Bomirski amelanotic hamster melanoma cells is stimulated by L-tyrosine.
Topics: Animals; Cricetinae; Insulin; Levodopa; Melanocyte-Stimulating Hormones; Melanoma, Experimental; Monophenol Monooxygenase; Tumor Cells, Cultured; Tyrosine | 1987 |
Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway, L-tyrosine and L-dopa.
Topics: Animals; Cricetinae; Levodopa; Melanins; Melanocytes; Melanoma; Monophenol Monooxygenase; Tumor Cells, Cultured; Tyrosine | 1988 |
Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat.
Topics: Animals; Brain; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Interactions; Duodenum; Erythrocytes; In Vitro Techniques; Ketones; Levodopa; Liver; Male; Pentanones; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
The effect of carbidopa on plasma and muscle levels of L-dopa, dopamine, and their metabolites following L-dopa administration to rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Drug Synergism; Homovanillic Acid; Levodopa; Muscles; Rats; Tyrosine | 1988 |
13C solid-state cross polarization/magic-angle-spinning nuclear magnetic resonance spectra of natural and synthetic melanins.
Topics: Animals; Carbon Isotopes; Choroid; Horse Diseases; Horses; Levodopa; Magnetic Resonance Spectroscopy; Melanins; Melanoma; Oxidation-Reduction; Tyrosine | 1988 |
Radiobrominated m-tyrosine analog as potential CNS L-dopa pet tracer.
Topics: Animals; Brain; Brain Chemistry; Bromine Radioisotopes; Cerebellum; Corpus Striatum; Female; Kidney; Kinetics; Levodopa; Liver; Mice; Tomography, Emission-Computed; Tyrosine | 1988 |
Effects of substrates for aromatic L-amino acid decarboxylase on insulin secretion.
Topics: 5-Hydroxytryptophan; Animals; Glucose; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Levodopa; Mice; Mice, Obese; Tyrosine | 1987 |
Stepwise detoxification from cocaine. A promising regimen.
Topics: Adolescent; Adult; Amantadine; Bromocriptine; Cocaine; Desipramine; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders; Tryptophan; Tyrosine | 1988 |
Single-dose pharmacokinetics of Madopar HBS in patients and effect of food and antacid on the absorption of Madopar HBS in volunteers.
Topics: Adult; Antacids; Benserazide; Biological Availability; Delayed-Action Preparations; Drug Combinations; Eating; Gastric Mucosa; Humans; Hydrazines; Levodopa; Middle Aged; Stomach; Tyrosine | 1987 |
3-O-methyldopa and motor fluctuations in Parkinson's disease.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Injections, Intravenous; Levodopa; Male; Middle Aged; Movement; Parkinson Disease; Tyrosine | 1987 |
3-O-methyldopa and the response to levodopa in Parkinson's disease.
Topics: Administration, Oral; Blood-Brain Barrier; Humans; Infusions, Intravenous; Levodopa; Parkinson Disease; Tyrosine | 1987 |
Interaction between specific dietary factors and experimental chemotherapy of metastatic melanoma.
Topics: Animals; Ascorbic Acid; Diet; Female; Levodopa; Lung Neoplasms; Melanoma; Mice; Mice, Inbred Strains; Phenylalanine; Tyrosine | 1986 |
Mobilization of storage pool dopamine and late ipsilateral augmentation of striatal dopamine synthesis in the trained circling rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Kinetics; Levodopa; Male; Motor Activity; Rats; Rats, Inbred Strains; Tyrosine | 1986 |
Modulation of peroxidation in murine melanoma by dietary tyrosine-phenylalanine restriction, levodopa methylester chemotherapy, and sodium ascorbate supplementation.
Topics: Animals; Ascorbic Acid; Diet; Female; Levodopa; Lipid Peroxides; Liver; Malondialdehyde; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenylalanine; Tyrosine | 1985 |
Malignant phenylketonuria due to defective synthesis of dihydrobiopterin.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Drug Combinations; Female; Humans; Infant, Newborn; Levodopa; Male; Nervous System Diseases; Phenylalanine; Phenylketonurias; Pteridines; Tyrosine | 1985 |
Catecholamine metabolism in the attention deficit disorder: implications for the use of amino acid precursor therapy.
Topics: Attention Deficit Disorder with Hyperactivity; Catecholamines; Dopamine; Humans; Levodopa; Methylphenidate; Norepinephrine; Pemoline; Tyrosine | 1985 |
Copper(II) and nickel(II) ternary complexes of L-dopa and related compounds.
Topics: Chemical Phenomena; Chemistry; Copper; Dopamine; Hydrogen-Ion Concentration; Kinetics; Levodopa; Ligands; Nickel; Osmolar Concentration; Phenylalanine; Structure-Activity Relationship; Tyrosine | 1985 |
Effects of L-dopa and L-tyrosine on release of free and conjugated dopamine, homovanillic acid and dihydroxyphenylacetic acid from slices of rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Calcium; Corpus Striatum; Dopamine; Homovanillic Acid; In Vitro Techniques; Levodopa; Male; Phenethylamines; Phenylacetates; Potassium; Rats; Tyrosine | 1985 |
Carbidopa dosage modifies L-dopa induced side effects and blood levels of L-dopa and other amino acids in advanced parkinsonism.
Topics: Aged; Carbidopa; Drug Therapy, Combination; Female; Homovanillic Acid; Humans; Kinetics; Levodopa; Male; Middle Aged; Parkinson Disease; Tryptophan; Tyrosine | 1985 |
Determination of m- and p-O-methylated products of L-3,4-dihydroxyphenylalanine using high-performance liquid chromatography and electrochemical detection.
Topics: Animals; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Isomerism; Levodopa; Liver; Methylation; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Protriptyline induced inhibition of the in vivo 3H-noradrenaline synthesis from 3H-L-dopa in the rat brain.
Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Brain Chemistry; Catecholamines; Cerebral Ventricles; Chromatography, Ion Exchange; Dibenzocycloheptenes; Homovanillic Acid; Injections; Levodopa; Male; Norepinephrine; Propylamines; Rats; Specific Pathogen-Free Organisms; Spectrometry, Fluorescence; Time Factors; Tritium; Tyrosine | 1974 |
[Effect of catecholamines and their analogs on the electric activity of a giant neuron identified in the subesophageal ganglia of the giant african snail (Achatina fulica Ferussac)].
Topics: Action Potentials; Animals; Catecholamines; Dopamine; Epinephrine; Homovanillic Acid; Levodopa; Mandelic Acids; Methoxyhydroxyphenylglycol; Neural Conduction; Neurons; Norepinephrine; Normetanephrine; Octopamine; Phenylalanine; Snails; Structure-Activity Relationship; Synephrine; Tyramine; Tyrosine | 1974 |
[The determination of bilirubin as azobilirubin in plasma and serum with the Greiner electronic selective analyzer GSA II (author's transl)].
Topics: Ascorbic Acid; Azo Compounds; Bilirubin; Chemistry, Clinical; Diazonium Compounds; Epinephrine; Hemoglobins; Hemolysis; Histidine; Humans; Hyperlipidemias; Levodopa; Methyldopa; Norepinephrine; Rifampin; Spectrophotometry, Ultraviolet; Statistics as Topic; Tyrosine | 1974 |
Variations in L-dopa absorption. Report of a parkinsonian patient with high plasma dopa concentration after therapeutical L-dopa dose.
Topics: Administration, Oral; Aged; Carbon Radioisotopes; Decarboxylation; Dihydroxyphenylalanine; Dopamine; Female; Humans; Injections, Intravenous; Levodopa; Male; Middle Aged; Parkinson Disease; Phenylalanine; Stimulation, Chemical; Sulfates; Tyrosine | 1974 |
Effect of L-DOPA on the synthesis and excretion of tyramine.
Topics: Animals; Brain Stem; Caudate Nucleus; Cerebellum; Dopamine; Humans; Hypothalamus; Levodopa; Octopamine; Pargyline; Parkinson Disease; Rats; Time Factors; Tritium; Tryptamines; Tyramine; Tyrosine | 1974 |
Effect of L-DOPA and analogues on central dopamine and noradrenaline mechanisms.
Topics: 5-Hydroxytryptophan; Acetamides; Animals; Apomorphine; Brain Chemistry; Clonidine; Corpus Striatum; Dopamine; Hydrazines; Levodopa; Methyldopa; Methyltyrosines; Movement; Nialamide; Norepinephrine; Octopamine; Rats; Receptors, Drug; Reflex; Reserpine; Spinal Cord; Stimulation, Chemical; Tyramine; Tyrosine | 1974 |
Catecholamines and congenital pain insensitivity.
Topics: Dopamine; Dysautonomia, Familial; Epinephrine; Hereditary Sensory and Autonomic Neuropathies; Humans; Lesch-Nyhan Syndrome; Levodopa; Norepinephrine; Pain Insensitivity, Congenital; Phenylketonurias; Skin; Tyrosine | 1984 |
Beta-adrenergic influence on brain concentrations of monoamine precursors.
Topics: Amino Acids; Animals; Brain Chemistry; Epinephrine; Isoproterenol; Levodopa; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Tryptophan; Tyrosine | 1984 |
Correlation between tyrosine hydroxylase activity, melanogenesis, and estradiol binding in human melanoma cells.
Topics: Breast Neoplasms; Cell Line; Cytosol; Estradiol; Fibroblasts; Humans; Kinetics; Levodopa; Melanins; Melanoma; Tamoxifen; Tyrosine; Tyrosine 3-Monooxygenase | 1982 |
The autoreceptor control of dopamine synthesis. An in vitro and in vivo comparison of dopamine agonists.
Topics: 4-Butyrolactone; Animals; Corpus Striatum; Dopamine; Haloperidol; In Vitro Techniques; Levodopa; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Synaptosomes; Tyrosine; Tyrosine 3-Monooxygenase | 1982 |
Steady-state kinetics of bovine striatal tyrosine hydroxylase.
Topics: Animals; Biopterins; Cattle; Corpus Striatum; Dopamine; Kinetics; Levodopa; Oxygen; Substrate Specificity; Tyrosine; Tyrosine 3-Monooxygenase | 1983 |
In vivo tyrosine hydroxylation in the diabetic rat retina: effect of tyrosine administration.
Topics: Animals; Diabetes Mellitus, Experimental; Hydroxylation; Levodopa; Male; Rats; Rats, Inbred Strains; Retina; Streptozocin; Tyrosine; Tyrosine 3-Monooxygenase | 1984 |
Influence of neurotropic drugs on neurogenic damages of internal organs induced by stress.
Topics: Animals; Catecholamines; Glucosephosphate Dehydrogenase; Levodopa; Neurons; Norepinephrine; Oxidative Phosphorylation; RNA; Stress, Physiological; Sympatholytics; Tyrosine | 1980 |
Inactivation of human tyrosinase by cysteine. Protection by dopa and tyrosine.
Topics: Catalase; Catechol Oxidase; Cells, Cultured; Cysteine; Humans; In Vitro Techniques; Levodopa; Melanoma; Monophenol Monooxygenase; Superoxide Dismutase; Tyrosine | 1984 |
Effects of drug-induced changes in brain monoamines on aggression and motor behavior in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Aggression; Amphetamine; Animals; Biogenic Amines; Brain Chemistry; Diet; Dose-Response Relationship, Drug; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Mice; Motor Activity; Tyrosine | 1984 |
Effects of L-dopa and L-tyrosine on adrenergic transmission in the canine saphenous vein.
Topics: Animals; Blood Vessels; Calcium; Cocaine; Corticosterone; Dogs; Dopamine; In Vitro Techniques; Levodopa; Norepinephrine; Saphenous Vein; Sympathetic Nervous System; Synaptic Transmission; Tyrosine; Vasoconstriction | 1982 |
Production by Bacillis subtilis of brown sporulation-associated pigments.
Topics: Bacillus subtilis; Culture Media; Histidine; Hydrogen-Ion Concentration; Levodopa; Manganese; Metals; Oxygen; Pigments, Biological; Spores, Bacterial; Tyrosine | 1983 |
Effect of triamcinolone acetonide on tyrosinase activity in a human melanoma cell line.
Topics: Carbon Radioisotopes; Catechol Oxidase; Cell Cycle; Cell Line; DNA Replication; Humans; Kinetics; Levodopa; Melanoma; Monophenol Monooxygenase; Triamcinolone Acetonide; Tritium; Tyrosine | 1984 |
Simultaneous determination of L-dopa and 3-O-methyldopa in human serum by high-performance liquid chromatography.
Topics: Adult; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Epinephrine; Humans; Levodopa; Male; Methyltyrosines; Norepinephrine; Parkinson Disease; Tyrosine | 1984 |
Decarboxylation of L-dopa and 5-hydroxytryptophan in dispersed rat pancreas acinar cells.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Binding, Competitive; Decarboxylation; Female; Histidine; In Vitro Techniques; Levodopa; Pancreas; Rats; Rats, Inbred Strains; Serotonin; Tryptophan; Tyrosine | 1984 |
Aminoacids--precursors of melanin synthesis in hamster melanoma.
Topics: Amino Acids; Animals; Cricetinae; Ferrous Compounds; Iron; Levodopa; Male; Melanins; Melanoma; Mesocricetus; Neoplasm Transplantation; Phenylalanine; Tryptophan; Tyrosine | 1984 |
The formation of 3-hydroxy-4-methoxyphenylalanine and 3-hydroxy-4-methoxyphenethylamine in plasma during L-DOPA therapy in patients with Parkinson's disease.
Topics: Aged; Dopamine; Humans; Levodopa; Methyltyrosines; Parkinson Disease; Tyrosine | 1984 |
Effects of 3-OM-dopa on monoamine metabolism in rat brain.
Topics: alpha-Methyltyrosine; Animals; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Dopamine; Levodopa; Male; Methyltyrosines; Norepinephrine; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1983 |
Treatment of depression by altering monoamine metabolism: precursors and metabolic inhibitors.
Topics: Biogenic Amines; Catecholamines; Depression; Humans; Levodopa; Monoamine Oxidase Inhibitors; Serotonin; Tryptophan; Tyrosine | 1984 |
Schistosoma mansoni: tyrosine, a putative in vivo substrate of phenol oxidase.
Topics: Animals; Catechol Oxidase; Dopamine; Female; Kinetics; Levodopa; Male; Oxygen Consumption; Proteins; Schistosoma mansoni; Substrate Specificity; Tyrosine | 1980 |
Specificity of the enzyme phenoloxidase and possible metabolic pathway of sclerotization in Paraplerurus sauridae.
Topics: Animals; Catechol Oxidase; Catechols; Dopamine; Hydroquinones; Levodopa; Monophenol Monooxygenase; Protocatechuate-3,4-Dioxygenase; Substrate Specificity; Trematoda; Tyramine; Tyrosine | 1980 |
Sex steroid receptor analysis in human melanoma.
Topics: Adult; Aged; Estradiol; Estrogen Antagonists; Female; Humans; Levodopa; Male; Melanins; Melanoma; Middle Aged; Monophenol Monooxygenase; Promegestone; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Tyrosine | 1980 |
A semiautomated method for the rapid determination of dopa: comparison of plasma and erythrocyte-dopa concentration in levodopa-treated patients.
Topics: Autoanalysis; Dihydroxyphenylalanine; Erythrocytes; Humans; Levodopa; Methyltyrosines; Parkinson Disease; Spectrometry, Fluorescence; Tyrosine | 1982 |
Isoprenaline increases brain concentrations of administered L-dopa and L-tryptophan in the rat.
Topics: Animals; Brain; Dopamine; Isoproterenol; Levodopa; Male; Rats; Rats, Inbred Strains; Tryptophan; Tyrosine | 1982 |
Sodium ascorbate enhancement of carbidopa-levodopa methyl ester antitumor activity against pigmented B16 melanoma.
Topics: Animals; Antineoplastic Agents; Ascorbic Acid; Carbidopa; Cell Line; Diet; Drug Synergism; Drug Therapy, Combination; Female; Injections, Intraperitoneal; Levodopa; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Phenylalanine; Tyrosine | 1983 |
Degradation of melanin by Aspergillus fumigatus.
Topics: Aspergillus fumigatus; Chitinases; Fungal Proteins; Glucan 1,3-beta-Glucosidase; Glucans; Glucosidases; Kinetics; Levodopa; Melanins; Pigments, Biological; Tyrosine | 1980 |
Dietary influence of tyrosine and phenylalanine on the response of B16 melanoma to carbidopa-levodopa methyl ester chemotherapy.
Topics: Animals; Carbidopa; Diet; Drug Evaluation, Preclinical; Female; Levodopa; Melanoma; Mice; Neoplasms, Experimental; Phenylalanine; Tyrosine | 1982 |
3-O-methyldopa blocks dopa metabolism in rat corpus striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Levodopa; Male; Methyltyrosines; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1982 |
Effects of centrally and systemically administered L-tyrosine and L-leucine on ovarian function in the old rat.
Topics: Aging; Animals; Catecholamines; Estrus; Female; Leucine; Levodopa; Ovary; Pregnancy; Preoptic Area; Rats; Serotonin; Tyrosine | 1980 |
Secretion of hypothalamic dopamine into pituitary stalk blood of aged female rats.
Topics: Aging; Animals; Dopamine; Estrus; Female; Hypothalamus; Levodopa; Median Eminence; Pituitary Gland; Pregnancy; Prolactin; Rats; Tyrosine | 1981 |
3-o-methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathway.
Topics: Animals; Corpus Striatum; Humans; Levodopa; Male; Methyltyrosines; Neural Pathways; Rats; Stereotyped Behavior; Substantia Nigra; Tyrosine | 1982 |
L-dopa competes with tyrosine and tryptophan for human brain uptake.
Topics: Aged; Benserazide; Blood-Brain Barrier; Brain; Female; Humans; Levodopa; Male; Parkinson Disease; Tryptophan; Tyrosine | 1980 |
An ultrastructural study of albinistic B-14 melanoma cells.
Topics: Animals; Cell Line; Chromatography, Thin Layer; Culture Media; Levodopa; Melanoma; Mice; Mice, Inbred C57BL; Microscopy, Electron; Neoplasms, Experimental; Pigmentation; Tyrosine | 1981 |
Synergistic induction of pineal gland N-acetyltransferase activity by amphetamine and L-DOPA.
Topics: Acetyltransferases; Amphetamine; Animals; Drug Synergism; Enzyme Induction; Levodopa; Male; Pineal Gland; Rats; Tyrosine | 1981 |
An experimental approach to the chemotherapy of melanoma.
Topics: Antineoplastic Agents; Dopamine; Humans; Indoles; Levodopa; Melanins; Melanoma; Skin Neoplasms; Tyrosine | 1980 |
Production of urine free dopamine from DOPA; a micropuncture study.
Topics: Animals; Denervation; Dopamine; Inulin; Kidney; Levodopa; Male; Rats; Tyrosine | 1980 |
Release of synaptosomal dopamine formed from tyrosine and L-DOPA.
Topics: Animals; Brain; Dopamine; Female; Kinetics; Levodopa; Mitochondria; Nalidixic Acid; Naphthyridines; Rats; Synaptosomes; Tyrosine | 1980 |
Quantitative microdialysis for studying the in vivo L-DOPA kinetics in blood and skeletal muscle of the dog.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Proteins; Calibration; Dialysis; Dogs; Dopamine; Injections, Intramuscular; Injections, Intravenous; Levodopa; Male; Methyldopa; Microchemistry; Muscle, Skeletal; Protein Binding; Reference Standards; Reproducibility of Results; Tyrosine | 1995 |
Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amidines; Animals; Biogenic Monoamines; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Neostriatum; Nitriles; Pyridones; Rats; Rats, Wistar; Stereotaxic Techniques; Tryptophan; Tyrosine | 1994 |
Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Dopamine; Homovanillic Acid; Humans; Levodopa; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 1995 |
L-DOPA metabolism in cortical and striatal tissues in an animal model of parkinsonism.
Topics: Animals; Dopamine; Levodopa; Male; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Tyrosine | 1995 |
Simultaneous determination of in vivo hydroxylation of tyrosine and tryptophan in rat striatum by microdialysis-HPLC: relationship between dopamine and serotonin biosynthesis.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Homovanillic Acid; Hydrazines; Hydroxyindoleacetic Acid; Hydroxylation; Kinetics; Levodopa; Male; Microdialysis; Rats; Rats, Wistar; Serotonin; Tryptophan; Tryptophan Hydroxylase; Tyrosine; Tyrosine 3-Monooxygenase | 1993 |
A specific tetrahydrobiopterin binding domain on tyrosinase controls melanogenesis.
Topics: Amino Acid Sequence; Animals; Basidiomycota; Binding Sites; Biopterins; Humans; Hydro-Lyases; Kinetics; Levodopa; Melanins; Mice; Molecular Sequence Data; Monophenol Monooxygenase; Phenylalanine Hydroxylase; Ranidae; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine | 1995 |
X-ray characterization of melanins--I.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Fourier Analysis; Levodopa; Mathematics; Melanins; Mollusca; Tyrosine; X-Ray Diffraction | 1994 |
The DHICA oxidase activity of the melanosomal tyrosinases LEMT and HEMT.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Indoles; Isoenzymes; Levodopa; Melanocytes; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1994 |
The COMT inhibitor tolcapone potentiates the anticataleptic effect of Madopar in MPP(+)-lesioned mice.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Benserazide; Benzophenones; Catalepsy; Catechol O-Methyltransferase Inhibitors; Drug Combinations; Drug Synergism; Haloperidol; Kinetics; Levodopa; Male; Mice; Mice, Inbred C57BL; Nitrophenols; Tolcapone; Tyrosine | 1994 |
Intense oxidative DNA damage promoted by L-dopa and its metabolites. Implications for neurodegenerative disease.
Topics: Brain Chemistry; Catalysis; Copper; DNA; DNA Damage; Dopamine; Humans; Hydrogen Peroxide; Iron; Levodopa; Oxidation-Reduction; Parkinson Disease; Tyrosine | 1994 |
Simultaneous determination of levodopa methyl ester, levodopa, 3-O-methyldopa and dopamine in plasma by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Humans; Levodopa; Oxidation-Reduction; Rats; Tyrosine | 1994 |
Pharmacokinetics of levodopa and carbidopa in rats following different routes of administration.
Topics: Absorption; Administration, Oral; Animals; Carbidopa; Chromatography, High Pressure Liquid; Half-Life; Injections, Intra-Arterial; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Intubation, Gastrointestinal; Levodopa; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Tyrosine | 1994 |
Cell inward transport of L-DOPA and 3-O-methyl-L-DOPA in rat renal tubules.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Chromatography, High Pressure Liquid; In Vitro Techniques; Kidney Tubules; Levodopa; Male; Rats; Rats, Wistar; Tyrosine | 1994 |
The effect of carbidopa on the pharmacokinetics and metabolism of intravenously administered levodopa in blood plasma and skeletal muscle.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Dogs; Dopamine; Extracellular Space; Half-Life; Injections, Intravenous; Levodopa; Male; Microdialysis; Muscles; Tyrosine | 1993 |
Simultaneous in vivo microdialysis in plasma and skeletal muscle: a study of the pharmacokinetic properties of levodopa by noncompartmental analysis.
Topics: Animals; Dogs; Levodopa; Male; Microdialysis; Muscles; Tyrosine | 1994 |
3-O-methyldopa attenuates the effects of Madopar on the haloperidol-induced cataleptic behavior and the locomotor activity in the mouse.
Topics: Animals; Benserazide; Catalepsy; Drug Combinations; Haloperidol; Levodopa; Male; Mice; Motor Activity; Tyrosine | 1994 |
Production of L-dihydroxyphenylalanine in Escherichia coli with the tyrosine phenol-lyase gene cloned from Erwinia herbicola.
Topics: Amino Acid Sequence; Base Sequence; Biotechnology; Chromosome Mapping; Cloning, Molecular; DNA, Bacterial; Erwinia; Escherichia coli; Genes, Bacterial; Lac Operon; Levodopa; Molecular Sequence Data; Tyrosine; Tyrosine Phenol-Lyase | 1993 |
Tyrosinase isoenzymes in mammalian melanocytes. 1. Biochemical characterization of two melanosomal tyrosinases from B16 mouse melanoma.
Topics: Animals; beta-Mannosidase; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Kinetics; Levodopa; Mannosidases; Melanocytes; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Neuraminidase; Trypsin; Tumor Cells, Cultured; Tyrosine | 1993 |
Formation of melanin pigment by a mutant of Bacillus thuringiensis H-14.
Topics: Amino Acids; Ascorbic Acid; Bacillus thuringiensis; Culture Media; Levodopa; Melanins; Mutagenesis; Spores, Bacterial; Tyrosine | 1993 |
Mucuna pruriens: improvement of the biotechnological production of the anti-Parkinson drug L-dopa by plant cell selection.
Topics: Alginates; Biotechnology; Catecholamines; Cells, Cultured; Glucuronic Acid; Hexuronic Acids; Levodopa; Light; Monophenol Monooxygenase; Photosynthesis; Plants; Tyrosine | 1993 |
Suppression of dyskinesias in advanced Parkinson's disease. I. Continuous intravenous levodopa shifts dose response for production of dyskinesias but not for relief of parkinsonism in patients with advanced Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Carbidopa; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Infusions, Intravenous; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease; Tyrosine | 1993 |
Plasma levels of levodopa and its main metabolites in parkinsonian patients after conventional and controlled-release levodopa-carbidopa associations.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Blood-Brain Barrier; Carbidopa; Delayed-Action Preparations; Dopamine; Dose-Response Relationship, Drug; Drug Combinations; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Tyrosine | 1993 |
Does tolerance develop to levodopa? Comparison of 2- and 21-H levodopa infusions.
Topics: Aged; Carbidopa; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Tolerance; Dyskinesia, Drug-Induced; Female; Humans; Infusions, Intravenous; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Tyrosine | 1993 |
The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Electrocardiography; Half-Life; Homovanillic Acid; Humans; Levodopa; Male; Nitriles; Reference Values; Tyrosine | 1993 |
Effects of 3-O-methyl on L-dopa-facilitated synthesis and efflux of dopamine from rat striatal slices.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Cerebrospinal Fluid; Corpus Striatum; Dopamine; Drug Interactions; Levodopa; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Tyrosine | 1995 |
Synthesis and evaluation of radioiodinated 6-iodo-L-DOPA as a cerebral L-amino acid transport marker.
Topics: Amino Acids; Animals; Biological Transport; Brain; Dihydroxyphenylalanine; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Levodopa; Liver; Male; Mice; Mice, Inbred Strains; Ouabain; Pancreas; Pancreatin; Rats; Tissue Distribution; Tomography, Emission-Computed; Tyrosine | 1996 |
Oxidative damage caused by free radicals produced during catecholamine autoxidation: protective effects of O-methylation and melatonin.
Topics: Catecholamines; Copper Sulfate; Deoxyepinephrine; Dopamine; Free Radicals; Levodopa; Melatonin; Methylation; Oxidation-Reduction; Phycoerythrin; Spectrometry, Fluorescence; Tyrosine | 1996 |
Phenoloxidase activity in the reproductive system and egg masses of the pulmonate gastropod, Biomphalaria glabrata.
Topics: Animals; Biomphalaria; Catechol Oxidase; Chromatography, High Pressure Liquid; Dopamine; Hydrogen-Ion Concentration; Levodopa; Monophenol Monooxygenase; Ovum; Reproduction; Temperature; Tyrosine | 1996 |
Catecholamine content and in vitro catecholamine synthesis in peripheral human lymphocytes.
Topics: Adult; alpha-Methyltyrosine; Aromatic Amino Acid Decarboxylase Inhibitors; B-Lymphocytes; Benserazide; Catecholamines; Chromatography, High Pressure Liquid; Disulfiram; Dopamine; Dopamine beta-Hydroxylase; Enzyme Inhibitors; Female; Fusaric Acid; Humans; Levodopa; Male; Methyltyrosines; Norepinephrine; T-Lymphocytes; Tyrosine; Tyrosine 3-Monooxygenase | 1996 |
Tyrosine and tryptophan derivatives in pig lumbar cerebrospinal fluid. Effects of subchronic administration of dopa associated with benserazide.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Benserazide; Drug Interactions; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Kynurenine; Levodopa; Male; Methoxyhydroxyphenylglycol; Normetanephrine; Swine; Tryptamines; Tryptophan; Tyrosine | 1996 |
An in vivo comparison of the capacity of striatal versus extrastriatal brain regions to form dopamine from exogenously administered L-dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biotransformation; Brain Chemistry; Cerebellum; Dopamine; Dopamine Agents; Extracellular Space; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Neostriatum; Occipital Lobe; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
Altered basal release and depressor effect of L-DOPA in the nucleus tractus solitarii of spontaneously hypertensive rats.
Topics: Animals; Dopamine; Dopamine Agents; Hypertension; Levodopa; Male; Microdialysis; Microinjections; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Solitary Nucleus; Tetrodotoxin; Tyrosine | 1995 |
Altered basal release and pressor effect of L-DOPA in the rostral ventrolateral medulla of spontaneously hypertensive rats.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Blood Pressure; Dopamine Agents; Glutamic Acid; Heart Rate; Hypertension; Levodopa; Male; Medulla Oblongata; Microdialysis; Microinjections; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrodotoxin; Tyrosine; Tyrosine 3-Monooxygenase | 1995 |
L-tyrosine and nicotine induce synthesis of L-Dopa and norepinephrine in human lymphocytes.
Topics: Acetylcholine; Adult; Blood Cells; Female; Humans; Levodopa; Lymphocytes; Male; Muscarine; Nicotine; Norepinephrine; Tyrosine | 1997 |
Melanin formation in the inner ear is catalyzed by a new tyrosine hydroxylase kinetically and structurally different from tyrosinase.
Topics: Animals; Catalysis; Cochlea; Gerbillinae; Kinetics; Levodopa; Melanins; Melanocytes; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Protein Conformation; Tumor Cells, Cultured; Tyrosine; Tyrosine 3-Monooxygenase | 1997 |
Determination of the L-DOPA/L-tyrosine ratio in human plasma by high-performance liquid chromatography. Usefulness as a marker in metastatic malignant melanoma.
Topics: Biomarkers, Tumor; Calibration; Chromatography, High Pressure Liquid; Circadian Rhythm; Humans; Hydrogen-Ion Concentration; Levodopa; Linear Models; Melanins; Melanoma; Reproducibility of Results; Skin Neoplasms; Spectrometry, Fluorescence; Tyrosine | 1997 |
Simultaneous determination of L-dopa and 3-O-methyldopa in human platelets and plasma using high-performance liquid chromatography with electrochemical detection.
Topics: Adult; Aged; Antiparkinson Agents; Blood Platelets; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1997 |
Renal response to infusion of dopamine precursors in anaesthetized rats.
Topics: Adrenal Glands; Animals; Blood Pressure; Dopamine; Glomerular Filtration Rate; Immunohistochemistry; Kidney; Levodopa; Male; Rats; Rats, Sprague-Dawley; Tyrosine; Tyrosine 3-Monooxygenase | 1997 |
Effects of the substituted (S)-3-phenylpiperidine (-)-OSU6162 on PET measurements in subhuman primates: evidence for tone-dependent normalization of striatal dopaminergic activity.
Topics: Animals; Biopterins; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Female; Levodopa; Macaca mulatta; Piperidines; Reference Values; Tomography, Emission-Computed; Tyrosine | 1998 |
Salsolinol, catecholamine metabolites, and visual hallucinations in L-dopa treated patients with Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Biomarkers; Catecholamines; Female; Hallucinations; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Isoquinolines; Levodopa; Male; Parkinson Disease; Reference Values; Regression Analysis; Tyrosine | 1996 |
Acetylcholine-induced, calcium-dependent norepinephrine outflow from peripheral human lymphocytes.
Topics: Acetylcholine; Adult; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Gallopamil; Humans; Ionomycin; Levodopa; Lymphocytes; Male; Norepinephrine; Tyrosine; Veratridine | 1998 |
Tyrosine transport into melanosomes is increased following stimulation of melanocyte differentiation.
Topics: Amino Acids; Animals; Biological Transport; Bucladesine; Cell Differentiation; Cell Line; Kinetics; Levodopa; Melanocyte-Stimulating Hormones; Melanocytes; Melanoma, Experimental; Mice; Models, Biological; Rats; Thyroid Gland; Tumor Cells, Cultured; Tyrosine | 1998 |
Protein L-dopa as an index of hydroxyl radical attack on protein tyrosine.
Topics: Animals; Chromatography, High Pressure Liquid; Hydroxyl Radical; Hydroxylation; Levodopa; Rats; Tyrosine | 1998 |
A comparative study on neurochemistry of cerebrospinal fluid in advanced Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Progression; Dopamine; Female; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1999 |
Acute overdosage and intoxication with carbidopa/levodopa can be detected in the subacute stage by measurement of 3-o-methyldopa.
Topics: Aged; Carbidopa; Dose-Response Relationship, Drug; Drug Combinations; Drug Overdose; Humans; Levodopa; Male; Time Factors; Tyrosine | 1999 |
Interaction between L-DOPA and 3-O-methyl-L-DOPA for transport in immortalised rat capillary cerebral endothelial cells.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; beta-Alanine; Biological Transport; Cells, Cultured; Cerebellum; Dopamine Agents; Drug Interactions; Endothelium, Vascular; Levodopa; Rats; Tyrosine | 1999 |
Development of metastases in malignant melanoma is associated with an increase in the plasma L-dopa/L-tyrosine ratio.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Female; Follow-Up Studies; Humans; Levodopa; Longitudinal Studies; Male; Melanoma; Middle Aged; Neoplasm Staging; Predictive Value of Tests; Prospective Studies; Reference Values; Skin Neoplasms; Tyrosine | 1999 |
Comparison of antipsychotic activity and discriminative stimulus effects of the novel acylprolyltyrosine containing compound, GZR-123, and sulpiride.
Topics: Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Discrimination, Psychological; Dopamine Agents; Dopamine Agonists; Exploratory Behavior; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Proline; Rats; Rats, Wistar; Stereotyped Behavior; Sulpiride; Tyrosine | 1999 |
Inhibition of tyrosinase by green tea components.
Topics: Agaricales; Enzyme Inhibitors; Kinetics; Korea; Levodopa; Monophenol Monooxygenase; Plant Extracts; Tea; Tyrosine | 1999 |
Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons.
Topics: Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Cell Survival; Cells, Cultured; Dopamine; Dopamine Agents; Enzyme Inhibitors; Levodopa; Mesencephalon; Neurons; Rats; S-Adenosylmethionine; Tyrosine | 2000 |
The effects of central aromatic amino acid DOPA decarboxylase inhibition on the motor actions of L-DOPA and dopamine agonists in MPTP-treated primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Callithrix; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hydrazines; Levodopa; Male; Motor Activity; Quinolones; Quinpirole; Thiophenes; Tyrosine | 2000 |
An improved synthesis of selectively protected L-dopa derivatives from L-tyrosine.
Topics: Indicators and Reagents; Levodopa; Oxidation-Reduction; Tyrosine | 2000 |
L-DOPA production by immobilized tyrosinase.
Topics: Agaricales; Ascorbic Acid; Chitin; Diamines; Enzymes, Immobilized; Glutaral; Kinetics; Levodopa; Monophenol Monooxygenase; Tyrosine | 2000 |
Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aromatic-L-Amino-Acid Decarboxylases; Carbidopa; Catheterization; Caudate Nucleus; Cell Line; Dependovirus; Dopamine; Drug Administration Routes; Drug Combinations; Fluorine Radioisotopes; Genetic Therapy; Genetic Vectors; Levodopa; Macaca mulatta; Magnetic Resonance Imaging; Neurons; Parkinson Disease, Secondary; Prodrugs; Putamen; Tomography, Emission-Computed; Tyrosine; Tyrosine 3-Monooxygenase | 2000 |
The influence of L-dopa on methylation capacity in aromatic L-amino acid decarboxylase deficiency: biochemical findings in two patients.
Topics: Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hypokinesia; Levodopa; Methoxyhydroxyphenylglycol; Methylation; Muscle Hypotonia; Tetrahydrofolates; Tyrosine | 2000 |
Manganese administration induces the increased production of dopamine sulfate and depletion of dopamine in Sprague-Dawley rats.
Topics: Administration, Oral; Animals; Brain; Chromatography, High Pressure Liquid; Dopamine; Heart; Kidney; Levodopa; Liver; Male; Manganese; Manganese Poisoning; Rats; Rats, Sprague-Dawley; Tyrosine | 2000 |
Catecholamines inhibit microglial nitric oxide production.
Topics: Adrenergic Agonists; Animals; Catecholamines; Cell Line; Central Nervous System Viral Diseases; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Isoproterenol; Levodopa; Lipopolysaccharides; Mice; Microglia; Nitric Oxide; Nitric Oxide Synthase; Phenylpropanolamine; Receptors, Adrenergic; Stress, Physiological; Tyrosine | 2000 |
Transformation of beta-amyloid (A beta) (1-42) tyrosine to L-dopa as the result of in vitro hydroxyl radical attack.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Chromatography, High Pressure Liquid; Humans; Hydroxyl Radical; Hydroxylation; Inflammation; Levodopa; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Tyrosine | 2000 |
Effect of 6-fluoro-m-tyrosine on dopamine release and metabolism in rat striatum using in vivo microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Fluorine Radioisotopes; Homovanillic Acid; Levodopa; Male; Microdialysis; Neostriatum; Neurons; Rats; Rats, Sprague-Dawley; Tyrosine | 2000 |
The central aromatic amino acid DOPA decarboxylase inhibitor, NSD-1015, does not inhibit L-DOPA-induced circling in unilateral 6-OHDA-lesioned-rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Biogenic Monoamines; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Dopamine Antagonists; Drug Combinations; Enzyme Inhibitors; Haloperidol; Homovanillic Acid; Hydrazines; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Rats; Rats, Wistar; Stereotyped Behavior; Tyrosine | 2001 |
Endogenous and new synthetic antioxidants for peroxynitrite: selective inhibitory effect of 5-methoxytryptamine and lipoic acid on tyrosine nitration by peroxynitrite.
Topics: 5-Methoxytryptamine; Antioxidants; Chromatography, High Pressure Liquid; Dopamine Agents; Levodopa; Nitrates; Oxidants; Oxidation-Reduction; Proline; Pyrrolidines; Thioctic Acid; Tyrosine | 1999 |
Plasma homocysteine and l-dopa metabolism in patients with Parkinson disease.
Topics: Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 2001 |
BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetophenones; Animals; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Methylation; Rats; Rats, Wistar; Time Factors; Tyrosine | 2001 |
Analysis and interpretation of the action mechanism of mushroom tyrosinase on monophenols and diphenols generating highly unstable o-quinones.
Topics: Agaricales; Catechol Oxidase; Dose-Response Relationship, Drug; Kinetics; Levodopa; Models, Chemical; Models, Theoretical; Monophenol Monooxygenase; Phenols; Quinones; Spectrophotometry; Tyrosine | 2001 |
L-dopa upregulates the expression and activities of methionine adenosyl transferase and catechol-O-methyltransferase.
Topics: Animals; Blotting, Western; Brain; Catechol O-Methyltransferase; Dopamine; Enzyme Induction; Kidney; Levodopa; Liver; Male; Methionine Adenosyltransferase; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tyrosine; Up-Regulation | 2001 |
COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Antiparkinson Agents; Benzophenones; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Disease Progression; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 2002 |
Role of tyrosinase in the genoprotective effect of the edible mushroom, Agaricus bisporus.
Topics: Agaricus; Ammonium Sulfate; Antimutagenic Agents; Chemical Precipitation; DNA Damage; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Hydroxylation; Levodopa; Lymphoma; Monophenol Monooxygenase; Tropolone; Tumor Cells, Cultured; Tyrosine | 2002 |
Microbiological transformation of L-tyrosine to 3,4-dihydroxyphenyl L-alanine (L-dopa) by a mutant strain of Aspergillus oryzae UV-7.
Topics: Alanine; Aspergillus oryzae; Biotransformation; Fermentation; Levodopa; Mutation; Temperature; Time Factors; Tyrosine | 2002 |
3-OMD and homocysteine plasma levels in parkinsonian patients.
Topics: Dihydroxyphenylalanine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 2002 |
Melanoma progression and serum L-dopa/L-tyrosine ratio: a comparison with S100B.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Bulgaria; Chromatography, High Pressure Liquid; Disease Progression; Female; Follow-Up Studies; Humans; Levodopa; Male; Melanoma; Middle Aged; Neoplasm Proteins; Neoplasm Staging; Nerve Growth Factors; Predictive Value of Tests; Prognosis; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Skin Neoplasms; Tyrosine | 2002 |
Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase.
Topics: Amino Acid Sequence; Animals; Biopterins; Catalytic Domain; Dopamine; Humans; Levodopa; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Phenylalanine; Phenylalanine Hydroxylase; Protein Binding; Rats; Sequence Alignment; Substrate Specificity; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
Truffle thio-flavours reversibly inhibit truffle tyrosinase.
Topics: Agaricus; Ascomycota; Catechols; Cresols; Ditiocarb; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fungal Proteins; Isoelectric Focusing; Kinetics; Levodopa; Mimosine; Molecular Weight; Monophenol Monooxygenase; Oxidation-Reduction; Phenylthiourea; Species Specificity; Substrate Specificity; Sulfides; Tyrosine | 2003 |
Inducive effect of cresoquinone on microbiological transformation of L-tyrosine to 3,4 dihydroxy phenyl L-alanine by Aspergillus oryzae NG-11(P1).
Topics: Aspergillus oryzae; Biotransformation; Carbon-Carbon Ligases; Fermentation; Fungal Proteins; Industrial Microbiology; Levodopa; Melanins; Monophenol Monooxygenase; Quinones; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
Light-induced modulation of self-assembly on spiropyran-capped gold nanoparticles: a potential system for the controlled release of amino acid derivatives.
Topics: Amino Acids; Benzopyrans; Delayed-Action Preparations; Gold; Indoles; Levodopa; Light; Nitro Compounds; Particle Size; Photochemistry; Spectrometry, Fluorescence; Tryptophan; Tyrosine | 2003 |
Modifications of plasma and platelet levels of L-DOPA and its direct metabolites during treatment with tolcapone or entacapone in patients with Parkinson's disease.
Topics: Age Factors; Age of Onset; Aged; Antiparkinson Agents; Benzophenones; Blood Platelets; Catechols; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Nitrophenols; Parkinson Disease; Retrospective Studies; Sex Characteristics; Tolcapone; Tyrosine; Up-Regulation | 2003 |
STUDIES ON ACTIVE TRANSPORT OF L-DOPA (DIHYDROXYPHENYLALANINE) INTO BRAIN SLICES.
Topics: Acetates; Alanine; Aniline Compounds; Animals; Biological Transport, Active; Calcium; Calcium, Dietary; Cerebral Cortex; Dihydroxyphenylalanine; Glutamates; Guinea Pigs; Ions; Levodopa; Magnesium; Metabolism; Phenols; Phenylalanine; Research; Sodium; Tyrosine | 1963 |
Evaluation of the serum L-dopa/L-tyrosine ratio as a melanoma marker.
Topics: Adult; Biomarkers, Tumor; Cell Line, Tumor; Chromatography, High Pressure Liquid; Female; Humans; Levodopa; Lymph Node Excision; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Nerve Growth Factors; Prognosis; Recurrence; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Time Factors; Tyrosine | 2003 |
Synthesis of lipophilic clovamide derivatives and their antioxidative potential against lipid peroxidation.
Topics: Antioxidants; Caffeic Acids; Coumaric Acids; Free Radical Scavengers; Levodopa; Lipid Peroxidation; Tyrosine | 2003 |
Analysis of catecholamines and related substances using porous graphitic carbon as separation media in liquid chromatography-tandem mass spectrometry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Chromatography, Liquid; Dopamine; Epinephrine; Graphite; Hydrogen-Ion Concentration; Levodopa; Norepinephrine; Spectrometry, Mass, Electrospray Ionization; Substantia Nigra; Swine; Tyrosine; Vanilmandelic Acid | 2004 |
Dopamine synthesis by non-dopaminergic neurons expressing individual complementary enzymes of the dopamine synthetic pathway in the arcuate nucleus of fetal rats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Aromatic-L-Amino-Acid Decarboxylases; Binding, Competitive; Cell Differentiation; Dopamine; Extracellular Fluid; Female; Fetus; Levodopa; Male; Neurons; Pregnancy; Rats; Rats, Wistar; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase; Up-Regulation | 2004 |
Simultaneous determination of levodopa and 3-O-methyldopa in human plasma by liquid chromatography with electrochemical detection.
Topics: Calibration; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Levodopa; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 2004 |
Behavioral and neurochemical effects of noradrenergic depletions with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in 6-hydroxydopamine-induced rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Basal Ganglia; Behavior, Animal; Benzylamines; Brain Chemistry; Catalepsy; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Locus Coeruleus; Male; Motor Activity; Norepinephrine; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Serotonin; Statistics, Nonparametric; Tyrosine | 2004 |
Cellular localization of monoamines in the area postrema of certain mammals.
Topics: Adrenergic Uptake Inhibitors; Animals; Area Postrema; Biogenic Monoamines; Cats; Dogs; Dopamine Agents; Guinea Pigs; Haplorhini; Levodopa; Microscopy, Fluorescence; Monoamine Oxidase Inhibitors; Neurons; Nialamide; Pargyline; Rabbits; Rats; Reserpine; Sympathectomy; Tyrosine | 1965 |
Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease.
Topics: Animals; Biopterins; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phenylalanine; Tyrosine | 2004 |
Melanin pigment formation and increased UV resistance in Bacillus thuringiensis following high temperature induction.
Topics: Animals; Bacillus thuringiensis; Bacillus thuringiensis Toxins; Bacterial Proteins; Bacterial Toxins; Endotoxins; Hemolysin Proteins; Levodopa; Melanins; Moths; Pest Control, Biological; Temperature; Tyrosine; Ultraviolet Rays | 2004 |
[Dopamine synthesis by non-dopaminergic neurons of the rat fetus arquate nucleus].
Topics: Animals; Arcuate Nucleus of Hypothalamus; Cell Extracts; Dopa Decarboxylase; Dopamine; Fetus; Levodopa; Neurons; Rats; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2004 |
Double mutant of Aspergillus oryzae for improved production of L-dopa (3,4-dihydroxyphenyl-L-alanine) from L-tyrosine.
Topics: Aspergillus oryzae; Hydrogen-Ion Concentration; Kinetics; Levodopa; Mutagenesis, Site-Directed; Nitrogen; Temperature; Thermodynamics; Tyrosine | 2005 |
Levodopa-responsive infantile parkinsonism due to a novel mutation in the tyrosine hydroxylase gene and exacerbation by viral infections.
Topics: Animals; Antiparkinson Agents; Central Nervous System Viral Diseases; Child, Preschool; DNA Mutational Analysis; Female; Histidine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Mice; Mutation; Parkinsonian Disorders; Rats; Treatment Outcome; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Dopamine synthesis by non-dopaminergic neurons in the arcuate nucleus of rat fetuses.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Female; Fetus; Levodopa; Male; Neurons; Pregnancy; Rats; Rats, Wistar; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Analogues of N-hydroxycinnamoylphenalkylamides as inhibitors of human melanocyte-tyrosinase.
Topics: Amides; Benzoquinones; Caffeic Acids; Catalysis; Cells, Cultured; Dihydroxyphenylalanine; Enzyme Inhibitors; Humans; Levodopa; Melanins; Melanocytes; Monophenol Monooxygenase; Oxidation-Reduction; Pigmentation Disorders; Pyrones; Skin; Structure-Activity Relationship; Tyramine; Tyrosine | 2006 |
Induction by Klebsiella aerogenes of a melanin-like pigment in Cryptococcus neoformans.
Topics: Animals; Bacterial Physiological Phenomena; Chromatography, High Pressure Liquid; Cryptococcus neoformans; Dictyostelium; Enterobacter aerogenes; Fluorescence; Fungi; Laccase; Levodopa; Mass Spectrometry; Melanins; Models, Biological; Pigments, Biological; Tyrosine | 2006 |
Hen egg white lysozyme as an inhibitor of mushroom tyrosinase.
Topics: Agaricales; Animals; Catalysis; Chickens; Egg Proteins; Inhibitory Concentration 50; Kinetics; Levodopa; Monophenol Monooxygenase; Muramidase; Tyrosine | 2006 |
Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of levodopa, 3-O-methyldopa, dopamine, carbidopa and 3,4-dihydroxyphenyl acetic acid.
Topics: 3,4-Dihydroxyphenylacetic Acid; Calibration; Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Levodopa; Tyrosine | 2006 |
Cabergoline scavenges peroxynitrite enhanced by L-DOPA therapy in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Cabergoline; Chromatography, High Pressure Liquid; Ergolines; Female; Free Radical Scavengers; Humans; Levodopa; Male; Oxidative Stress; Parkinson Disease; Peroxynitrous Acid; Tyrosine | 2006 |
The absence of phosphorylated tyrosine hydroxylase expression in the purkinje cells of the ataxic mutant pogo mouse.
Topics: Animals; Cerebellar Ataxia; Fluorescent Antibody Technique; Immunohistochemistry; Levodopa; Mice; Mice, Mutant Strains; Phosphorylation; Purkinje Cells; Tissue Distribution; Tyrosine; Tyrosine 3-Monooxygenase | 2006 |
Comparison of in vitro antioxidant and antiradical activities of L-tyrosine and L-Dopa.
Topics: Free Radical Scavengers; Levodopa; Reactive Oxygen Species; Tyrosine | 2007 |
Innovative effect of illite on improved microbiological conversion of L-tyrosine to 3,4 dihydroxy phenyl L-alanine (L-DOPA) by Aspergillus oryzae ME2 under acidic reaction conditions.
Topics: Aspergillus oryzae; Hydrogen-Ion Concentration; Levodopa; Minerals; Tyrosine | 2006 |
Role of catechol structure in the adsorption and transformation reactions of L-DOPA in soils.
Topics: Adsorption; Catechin; Catechols; Hydrogen-Ion Concentration; Kinetics; Lactuca; Levodopa; Mucuna; Phenylalanine; Plant Growth Regulators; Soil; Structure-Activity Relationship; Tyrosine; Volcanic Eruptions | 2007 |
Clinical value of combined determination of plasma L-DOPA/tyrosine ratio, S100B, MIA and LDH in melanoma.
Topics: Aged; Antigens, Tumor-Associated, Carbohydrate; Biomarkers, Tumor; Female; Humans; Levodopa; Male; Melanoma; Middle Aged; Prospective Studies; S100 Proteins; Sensitivity and Specificity; Skin Neoplasms; Survival Analysis; Tyrosine | 2007 |
Assay of tyrosine hydroxylase based on high-performance liquid chromatography separation and quantification of L-dopa and L-tyrosine.
Topics: Biological Assay; Chromatography, High Pressure Liquid; Dopamine Agents; Drug Stability; Enzyme Activation; Hydrogen-Ion Concentration; Levodopa; Oxidation-Reduction; Reproducibility of Results; Sensitivity and Specificity; Temperature; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2007 |
Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase.
Topics: Catalysis; Flavanones; Kinetics; Levodopa; Molecular Structure; Monophenol Monooxygenase; Oxidation-Reduction; Peptides; Structure-Activity Relationship; Tyrosine | 2007 |
High performance microbiological transformation of L-tyrosine to L-dopa by Yarrowia lipolytica NRRL-143.
Topics: Biomass; Biotransformation; Diatomaceous Earth; Fungal Proteins; Industrial Microbiology; Kinetics; Levodopa; Models, Biological; Monophenol Monooxygenase; Tyrosine; Yarrowia | 2007 |
The role of 3-O-methyldopa in the side effects of L-dopa.
Topics: Animals; Antiparkinson Agents; Benzazepines; Brain Chemistry; Catecholamines; Cell Survival; Chromatography, High Pressure Liquid; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Levodopa; Male; Membrane Potentials; Mitochondrial Membranes; Motor Activity; PC12 Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Dopamine D1; Synaptic Transmission; Tyrosine | 2008 |
Parasite suppression of the oxidations of eumelanin precursors in Drosophila melanogaster.
Topics: Animals; Chromatography, High Pressure Liquid; Dopamine; Drosophila melanogaster; Electrochemistry; Host-Parasite Interactions; Indoles; Levodopa; Melanins; Oxidation-Reduction; Phenols; Tyrosine; Wasps | 2007 |
Inhibition kinetics of cabbage butterfly (Pieris rapae L.) larvae phenoloxidase activity by 3-hydroxy-4-methoxybenzaldehyde thiosemicarbazone.
Topics: Animals; Butterflies; Guaiacol; Kinetics; Larva; Levodopa; Models, Molecular; Molecular Structure; Monophenol Monooxygenase; Oxidation-Reduction; Oxidoreductases; Protein Binding; Thiosemicarbazones; Tyrosine | 2007 |
Performance evaluation of a silk protein-based matrix for the enzymatic conversion of tyrosine to L-DOPA.
Topics: Enzymes, Immobilized; Fibroins; Glutaral; Levodopa; Monophenol Monooxygenase; Silk; Spectroscopy, Fourier Transform Infrared; Tyrosine | 2008 |
Coupling of complex aromatic ring vibrations to solvent through hydrogen bonds: effect of varied on-ring and off-ring hydrogen-bonding substitutions.
Topics: Amino Acids, Aromatic; Biogenic Amines; Dopamine; Epinephrine; Hydrogen Bonding; Levodopa; Models, Chemical; Norepinephrine; Phenylalanine; Quantum Theory; Solvents; Spectrophotometry, Infrared; Temperature; Tyrosine; Vibration | 2008 |
A novel missense mutation pattern of the GCH1 gene in dopa-responsive dystonia.
Topics: Child; Dopamine Agents; Dystonia; Female; GTP Cyclohydrolase; Heterozygote; Humans; Levodopa; Mutation, Missense; Phenylalanine; Tyrosine | 2007 |
Chemosorption of radiometals of interest to nuclear medicine by synthetic melanins.
Topics: Actinium; Adsorption; Bismuth; Cysteine; Dopamine; Gamma Rays; Indium Radioisotopes; Levodopa; Melanins; Nuclear Medicine; Radiochemistry; Scintillation Counting; Tyrosine | 2008 |
Inhibitory effect of p-coumaric acid by Rhodiola sachalinensis on melanin synthesis in B16F10 cells.
Topics: alpha-MSH; Blotting, Western; Catechin; Cell Survival; Chlorogenic Acid; Coumaric Acids; Cyclic AMP Response Element-Binding Protein; Humans; Levodopa; Melanins; Melanoma, Experimental; Monophenol Monooxygenase; Phenylethyl Alcohol; Phosphorylation; Propionates; Rhodiola; Tyrosine | 2008 |
L-DOPA is an endogenous ligand for OA1.
Topics: Albinism; Animals; Autocrine Communication; Calcium; Cell Line; Dopamine; Dopamine Agents; Eye Proteins; Humans; Levodopa; Ligands; Membrane Glycoproteins; Monophenol Monooxygenase; Nerve Growth Factors; Pigment Epithelium of Eye; Protease Inhibitors; Receptors, Dopamine; Serpins; Signal Transduction; Tyrosine | 2008 |
Lincomycin, rational selection of high producing strain and improved fermentation by amino acids supplementation.
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Biomedical Engineering; Bioreactors; Fermentation; Levodopa; Lincomycin; Mutation; Proline; Pyruvate Kinase; Streptomyces; Tyrosine | 2009 |
"Jerky" dystonia in children: spectrum of phenotypes and genetic testing.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antiparkinson Agents; Child; Child, Preschool; DNA Mutational Analysis; Dystonia; Exons; Female; Genetic Testing; Genotype; Humans; Hyperkinesis; Levodopa; Longitudinal Studies; Male; Middle Aged; Muscle, Skeletal; Mutation; Myoclonus; Nuclear Proteins; Phenotype; Sarcoglycans; Severity of Illness Index; Thyroid Nuclear Factor 1; Transcription Factors; Tyrosine; Young Adult | 2009 |
Transformation of L-tyrosine to L-dopa by a novel fungus, Acremonium rutilum, under submerged fermentation.
Topics: Acremonium; Animals; Biotransformation; Culture Techniques; Fermentation; Fishes; Fungal Proteins; Levodopa; Monophenol Monooxygenase; Musa; Soil Microbiology; Temperature; Tyrosine | 2009 |
In vitro effect of ozagrel on mushroom tyrosinase.
Topics: Agaricales; Catechol Oxidase; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Levodopa; Linear Models; Methacrylates; Monophenol Monooxygenase; Oxidoreductases; Tyrosine | 2009 |
Production of L-DOPA and dopamine in recombinant bacteria bearing the Vitreoscilla hemoglobin gene.
Topics: Bacterial Proteins; Citrobacter freundii; Dopamine; Erwinia; Hemeproteins; Levodopa; Recombinant Proteins; Truncated Hemoglobins; Tyrosine; Tyrosine Phenol-Lyase | 2009 |
Peripheral COMT inhibition prevents levodopa associated homocysteine increase.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Delayed-Action Preparations; Dihydroxyphenylalanine; Enzyme Inhibitors; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Time Factors; Tyrosine | 2009 |
Isolation, cloning and characterization of a tyrosinase with improved activity in organic solvents from Bacillus megaterium.
Topics: Amino Acid Sequence; Bacillus megaterium; Bacterial Proteins; Cloning, Molecular; DNA, Bacterial; DNA, Ribosomal; Enzyme Activators; Enzyme Stability; Escherichia coli; Gene Expression; Hydrogen-Ion Concentration; Kinetics; Levodopa; Molecular Sequence Data; Molecular Weight; Monophenol Monooxygenase; Organic Chemicals; RNA, Ribosomal, 16S; Sequence Alignment; Sequence Analysis, DNA; Soil Microbiology; Solvents; Temperature; Tyrosine | 2009 |
Melanogenesis inhibition by tetrahydropterines.
Topics: Agaricales; Binding, Competitive; Enzyme Inhibitors; Kinetics; Levodopa; Melanins; Monophenol Monooxygenase; Oxidation-Reduction; Pterins; Substrate Specificity; Tyrosine | 2009 |
Caffeic acid improves the bioavailability of L-dopa in rabbit plasma.
Topics: Animals; Caffeic Acids; Carbidopa; Coumaric Acids; Levodopa; Rabbits; Tyrosine | 2010 |
Electroenzymatic synthesis of l-DOPA.
Topics: Bioreactors; Electrochemical Techniques; Electrodes; Enzymes, Immobilized; Kinetics; Levodopa; Linear Models; Monophenol Monooxygenase; Parkinson Disease; Tyrosine | 2010 |
Radical sequestration by protein-bound 3,4-dihydroxyphenylalanine.
Topics: Amidines; Animals; Atherosclerosis; Cell Differentiation; Cell Line; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Levodopa; Luminescent Agents; Mice; Monocytes; Oxidants; Oxidation-Reduction; Oxidative Stress; Protein Transport; Proteins; Tyrosine | 2010 |
L-Ascorbate, a strong inducer of L-dopa (3,4-dihydroxy-L-phenylalanine) production from pre-grown mycelia of Aspergillus oryzae NRRL-1560.
Topics: Ascorbic Acid; Aspergillus oryzae; Chromatography, High Pressure Liquid; Fuzzy Logic; Levodopa; Tyrosine | 2010 |
Temporal and periovulatory changes in ovarian catecholamines in the catfish Heteropneustes fossilis.
Topics: Animals; Catecholamines; Catfishes; Chromatography, High Pressure Liquid; Circadian Rhythm; Dopamine; Epinephrine; Female; Levodopa; Norepinephrine; Ovary; Reproduction; Tyrosine | 2010 |
Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease.
Topics: Aged; alpha-Synuclein; Antiparkinson Agents; Autophagy; Female; Gene Frequency; Genotype; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Polymorphism, Genetic; Promoter Regions, Genetic; Reactive Oxygen Species; Sex Distribution; Tyrosine | 2010 |
Bioconversion of L-tyrosine to L-DOPA by a novel bacterium Bacillus sp. JPJ.
Topics: Ascorbic Acid; Bacillus; Biotransformation; Copper Sulfate; Enzyme Assays; Hydrogen-Ion Concentration; Kinetics; Levodopa; Monophenol Monooxygenase; Phylogeny; Tyrosine | 2011 |
Common pathogenic pathways in melanoma and Parkinson disease.
Topics: Brain Neoplasms; Group VI Phospholipases A2; Humans; Levodopa; Melanoma; Neural Pathways; Parkinson Disease; Tyrosine | 2010 |
Production of 3,4-dihydroxy L-phenylalanine by a newly isolated Aspergillus niger and parameter significance analysis by Plackett-Burman design.
Topics: Aspergillus niger; Culture Media; Glucose; Hydrogen-Ion Concentration; Kinetics; Levodopa; Mycelium; Nitrogen; Potassium; Tyrosine | 2010 |
Proteins containing oxidized amino acids induce apoptosis in human monocytes.
Topics: Aging; Annexin A5; Apoptosis; Caspase 3; Cell Line; Ceroid; DNA Fragmentation; Enzyme Activation; Humans; Intracellular Membranes; Levodopa; Lipofuscin; Lysosomes; Membrane Potential, Mitochondrial; Mitochondrial Membranes; Monocytes; Oxidation-Reduction; Permeability; Protein Biosynthesis; Tyrosine | 2011 |
Tetrahydrofolic Acid is a potent suicide substrate of mushroom tyrosinase.
Topics: Agaricales; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kinetics; Levodopa; Monophenol Monooxygenase; Substrate Specificity; Tetrahydrofolates; Tyrosine | 2011 |
Spectroscopic analyses on interaction of o-Vanillin-D-Phenylalanine, o-Vanillin-L-Tyrosine and o-Vanillin-L-Levodopa Schiff Bases with bovine serum albumin (BSA).
Topics: Animals; Benzaldehydes; Cattle; Dopamine Agents; Levodopa; Molecular Structure; Phenylalanine; Schiff Bases; Serum Albumin, Bovine; Tyrosine | 2011 |
Cysteinyl-glycine reduction as marker for levodopa-induced oxidative stress in Parkinson's disease patients.
Topics: Analysis of Variance; Antiparkinson Agents; Carbidopa; Dipeptides; Female; Humans; Levodopa; Male; Oxidative Stress; Parkinson Disease; Tyrosine | 2011 |
Metabolic engineering of Escherichia coli for improving L-3,4-dihydroxyphenylalanine (L-DOPA) synthesis from glucose.
Topics: 3-Deoxy-7-Phosphoheptulonate Synthase; Chorismate Mutase; Escherichia coli; Glucose; Levodopa; Metabolic Engineering; Mixed Function Oxygenases; Phosphoenolpyruvate Sugar Phosphotransferase System; Plasmids; Prephenate Dehydratase; Prephenate Dehydrogenase; Transketolase; Tyrosine; Zymomonas | 2011 |
Cloning and expression of a tyrosinase from Aspergillus oryzae in Yarrowia lipolytica: application in L-DOPA biotransformation.
Topics: Aspergillus oryzae; Base Sequence; Biotransformation; Cloning, Molecular; Fungal Proteins; Gene Expression; Levodopa; Molecular Sequence Data; Monophenol Monooxygenase; Tyrosine; Yarrowia | 2011 |
Pyridoxal phosphate-responsive seizures in a patient with cerebral folate deficiency (CFD) and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM).
Topics: Base Sequence; Child; Codon, Nonsense; Congenital Abnormalities; Congenital Microtia; Dihydroxyphenylalanine; DNA Primers; Ear; Ear, Inner; Electroencephalography; Epilepsy; Fibroblast Growth Factor 3; Folate Receptor 1; Folic Acid Deficiency; Humans; Levodopa; Male; Molecular Sequence Data; Pyridoxal Phosphate; Radiography; Sequence Analysis, DNA; Skull; Syndrome; Tooth Abnormalities; Tyrosine | 2011 |
A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin.
Topics: Anthramycin; Cloning, Molecular; Electron Spin Resonance Spectroscopy; Escherichia coli; Heme; Hydrogen Peroxide; Kinetics; Levodopa; Models, Chemical; Oxygen; Peroxidases; Spectrophotometry, Ultraviolet; Streptomyces; Tyrosine; Tyrosine 3-Monooxygenase | 2011 |
Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors.
Topics: Agaricales; alpha-MSH; Animals; Cell Survival; Enzyme Inhibitors; Kinetics; Levodopa; Melanins; Melanoma, Experimental; Mice; Models, Molecular; Monophenol Monooxygenase; Phenylthiourea; Protein Structure, Tertiary; Thiazolidines; Tumor Cells, Cultured; Tyrosine | 2012 |
Enhanced production of L-DOPA in cell cultures of Mucuna pruriens L. and Mucuna prurita H.
Topics: Acetates; Catechol Oxidase; Cell Culture Techniques; Cell Division; Chitin; Culture Media; Cyclopentanes; Levodopa; Monophenol Monooxygenase; Mucuna; Oxylipins; Pectins; Species Specificity; Spectrophotometry, Ultraviolet; Tyrosine | 2012 |
Bacterial and eukaryotic phenylalanyl-tRNA synthetases catalyze misaminoacylation of tRNA(Phe) with 3,4-dihydroxy-L-phenylalanine.
Topics: Catalytic Domain; Cytoplasm; Eukaryota; Humans; Levodopa; Mitochondria; Phenylalanine-tRNA Ligase; Protein Conformation; RNA Editing; RNA, Transfer, Amino Acyl; Thermus thermophilus; Tyrosine | 2011 |
Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Biomarkers; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Disease Progression; Dopa Decarboxylase; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Japan; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Parkinson Disease; Prospective Studies; Treatment Outcome; Tyrosine | 2011 |
Continuous-flow step gradient mass spectrometry based method for the determination of kinetic parameters of immobilized mushroom tyrosinase in equilibrating conditions: comparison with free enzyme.
Topics: Agaricales; Bioreactors; Enzymes, Immobilized; Kinetics; Levodopa; Mass Spectrometry; Monophenol Monooxygenase; Reproducibility of Results; Sensitivity and Specificity; Temperature; Tyrosine | 2011 |
Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor.
Topics: Agaricales; Animals; Cell Differentiation; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Kinetics; Levodopa; Melanins; Mice; Monophenol Monooxygenase; Oxidation-Reduction; Resveratrol; Stilbenes; Tyrosine | 2012 |
Chromatographic assay to study the activity of multiple enzymes involved in the synthesis and metabolism of dopamine and serotonin.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Biological Assay; Central Nervous System; Chromatography; Dopamine; Dopamine Agents; Hydroxyindoleacetic Acid; Levodopa; Lymnaea; Models, Biological; Molecular Structure; Serotonin; Tryptophan; Tyrosine | 2012 |
Efficient microbial conversion of L-tyrosine to L-DOPA by Brevundimonas sp. SGJ.
Topics: Ascorbic Acid; Biotransformation; Caulobacteraceae; Cell Size; Copper Sulfate; Hydrogen-Ion Concentration; Levodopa; Monophenol Monooxygenase; Motion; Temperature; Time Factors; Tyrosine | 2012 |
In vivo catecholaminergic metabolism in the medial prefrontal cortex of ENU2 mice: an investigation of the cortical dopamine deficit in phenylketonuria.
Topics: Animals; Catecholamines; Disease Models, Animal; Dopamine; Levodopa; Male; Mice; Mice, Mutant Strains; Phenylalanine Hydroxylase; Phenylketonurias; Prefrontal Cortex; Synaptic Transmission; Tyrosine; Tyrosine 3-Monooxygenase | 2012 |
Isolation and characterization of novel tyrosinase from Laceyella sacchari.
Topics: Bacillales; Bacterial Proteins; Base Sequence; DNA, Bacterial; Dopamine; Enzyme Stability; Hydrogen-Ion Concentration; Kinetics; Levodopa; Molecular Sequence Data; Monophenol Monooxygenase; RNA, Ribosomal, 16S; Sequence Alignment; Tyrosine | 2012 |
Effects of 3-O-methyldopa, L-3,4-dihydroxyphenylalanine metabolite, on locomotor activity and dopamine turnover in rats.
Topics: Animals; Antiparkinson Agents; Brain; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Motor Activity; Parkinson Disease; Rats; Rats, Wistar; Tyrosine | 2012 |
Pigmented-MDCK (P-MDCK) cell line with tunable melanin expression: an in vitro model for the outer blood-retinal barrier.
Topics: Animals; Biological Transport; Blood-Retinal Barrier; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Chloroquine; Chromatography, Liquid; Dogs; Electric Impedance; Humans; Immunoenzyme Techniques; Kidney; Levodopa; Madin Darby Canine Kidney Cells; Melanins; Mice; Monophenol Monooxygenase; Pigment Epithelium of Eye; Pigmentation; Salicylic Acid; Tandem Mass Spectrometry; Tyrosine | 2012 |
Betacyanin and other antioxidants production during growth of Opuntia stricta (Haw.) fruits.
Topics: Antioxidants; Betacyanins; Biomass; Biosynthetic Pathways; Carbohydrate Metabolism; Carbohydrates; Fruit; Levodopa; Opuntia; Phenols; Pigments, Biological; Plant Extracts; Tyrosine | 2012 |
Resveratrol attenuates L-DOPA-induced hydrogen peroxide toxicity in neuronal cells.
Topics: Antioxidants; Catechin; Cell Line, Tumor; Cell Survival; Drug Evaluation, Preclinical; Drug Interactions; Fibroblasts; Fluoresceins; Humans; Hydrogen Peroxide; Levodopa; Monoamine Oxidase; Nerve Tissue Proteins; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidative Stress; Quercetin; Resveratrol; Stilbenes; Tyrosine; Tyrosine 3-Monooxygenase | 2012 |
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antiparkinson Agents; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluoresceins; Glial Fibrillary Acidic Protein; Hippocampus; Hydroxybenzoates; In Vitro Techniques; Kainic Acid; Levodopa; Male; Methylation; Mice; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors; Tyrosine | 2013 |
Pharmacokinetics of levodopa, carbidopa, and 3-O-methyldopa following 16-hour jejunal infusion of levodopa-carbidopa intestinal gel in advanced Parkinson's disease patients.
Topics: Aged; Antiparkinson Agents; Biotransformation; Carbidopa; Chemistry, Pharmaceutical; Drug Combinations; Female; Gels; Germany; Humans; Infusion Pumps; Intestinal Absorption; Intubation, Gastrointestinal; Jejunum; Levodopa; Male; Middle Aged; Parkinson Disease; Sweden; Tyrosine | 2013 |
Influencing the monophenolase/diphenolase activity ratio in tyrosinase.
Topics: Amino Acid Substitution; Bacillus megaterium; Bacterial Proteins; Biocatalysis; Catalytic Domain; Catechol Oxidase; Copper; Crystallography, X-Ray; Ipomoea batatas; Kinetics; Levodopa; Models, Molecular; Monophenol Monooxygenase; Mutation; Oxidation-Reduction; Oxidoreductases; Plant Proteins; Substrate Specificity; Tyrosine; Valine | 2013 |
Pitfalls in phenylalanine loading test in the diagnosis of dopa-responsive dystonia.
Topics: Administration, Oral; Adult; Biopterins; Diagnosis, Differential; Dystonia; Dystonic Disorders; Female; Humans; Levodopa; Metabolism, Inborn Errors; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Psychomotor Disorders; Tyrosine | 2013 |
Indirect inactivation of tyrosinase in its action on 4-tert-butylphenol.
Topics: Agaricales; Catechols; Enzyme Assays; Enzyme Inhibitors; Fungal Proteins; Kinetics; Levodopa; Oxidation-Reduction; Oxygen; Phenols; Solutions; Substrate Specificity; Tyrosine | 2014 |
Cardiovascular changes in atherosclerotic ApoE-deficient mice exposed to Co60 (γ) radiation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apolipoproteins E; Atherosclerosis; Cholesterol; Cobalt Radioisotopes; Deoxyguanosine; Dinoprost; DNA Damage; Endothelins; Endothelium, Vascular; Female; Levodopa; Lipid Peroxidation; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Nitrites; Oxidative Stress; Plaque, Atherosclerotic; Radiation Injuries, Experimental; Tyrosine | 2013 |
Purification and characterization of RNA allied extracellular tyrosinase from Aspergillus species.
Topics: Aspergillus flavus; Chromatography, Affinity; Chromatography, Ion Exchange; Levodopa; Monophenol Monooxygenase; RNA; Temperature; Tyrosine | 2014 |
Microbiological transformation of L-tyrosine to L-dopa from methanol pretreated biomass of a novel Coriolus versicolor under submerged culture.
Topics: Biomass; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Levodopa; Methanol; Tyrosine | 2014 |
A dual-tracer study of extrastriatal 6-[18F]fluoro-m-tyrosine and 6-[18F]-fluoro-L-dopa uptake in Parkinson's disease.
Topics: Brain; Dihydroxyphenylalanine; Disease Progression; Female; Fluorine Radioisotopes; Humans; Image Processing, Computer-Assisted; Levodopa; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Time Factors; Tyrosine | 2014 |
Alleviation effect of arbutin on oxidative stress generated through tyrosinase reaction with L-tyrosine and L-DOPA.
Topics: Arbutin; Electron Spin Resonance Spectroscopy; Levodopa; Monophenol Monooxygenase; Oxidative Stress; Tyrosine | 2014 |
NR2B antagonist CP-101,606 inhibits NR2B phosphorylation at tyrosine-1472 and its interactions with Fyn in levodopa-induced dyskinesia rat model.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Levodopa; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-fyn; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2015 |
Simultaneous determination of levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma by an HPLC-MS/MS method.
Topics: Benzophenones; Blood Chemical Analysis; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Nitriles; Nitrophenols; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry; Tolcapone; Tyrosine | 2015 |
Identification and molecular characterization of the homogentisate pathway responsible for pyomelanin production, the major melanin constituents in Aeromonas media WS.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Aeromonas; Biosynthetic Pathways; Chromatography, High Pressure Liquid; DNA Transposable Elements; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Testing; Homogentisic Acid; Levodopa; Melanins; Mutagenesis; Phenylpyruvic Acids; Pigmentation; Transcription, Genetic; Tyrosine | 2015 |
Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats.
Topics: Animals; Benzofurans; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Kinetics; Levodopa; Male; Metabolome; Methylation; Nitrophenols; Organ Specificity; Rats, Sprague-Dawley; Reproducibility of Results; Substrate Specificity; Tolcapone; Tyrosine | 2015 |
Identification of p-hydroxybenzyl alcohol, tyrosol, phloretin and its derivate phloridzin as tyrosinase substrates.
Topics: Benzyl Alcohols; Enzyme Assays; Enzyme Inhibitors; Fungal Proteins; Kinetics; Levodopa; Monophenol Monooxygenase; Phenylacetates; Phenylethyl Alcohol; Phloretin; Phlorhizin; Substrate Specificity; Tyrosine | 2015 |
Integrated theory to unify status among schizophrenia and manic depressive illness.
Topics: 5-Hydroxytryptophan; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Biopterins; Bipolar Disorder; Blood-Brain Barrier; Depression; Depression, Postpartum; Dopamine; Female; Hallucinations; Humans; Kynurenic Acid; Levodopa; Male; Neuroleptic Malignant Syndrome; Neurotransmitter Agents; Paranoid Disorders; Premenstrual Syndrome; Schizophrenia; Seasonal Affective Disorder; Serotonin; Serotonin Syndrome; Tyrosine | 2015 |
Kinetic characterization of substrate-analogous inhibitors of tyrosinase.
Topics: Cinnamates; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fungal Proteins; Kinetics; Levodopa; Monophenol Monooxygenase; Tyrosine | 2015 |
Kinetic characterization of oxyresveratrol as a tyrosinase substrate.
Topics: Fungal Proteins; Hydrogen Peroxide; Hydroxylation; Kinetics; Levodopa; Monophenol Monooxygenase; Plant Extracts; Resveratrol; Stilbenes; Substrate Specificity; Tyrosine | 2015 |
Evaluation of 6-11C-Methyl-m-Tyrosine as a PET Probe for Presynaptic Dopaminergic Activity: A Comparison PET Study with β-11C-l-DOPA and 18F-FDOPA in Parkinson Disease Monkeys.
Topics: Animals; Brain; Carbidopa; Dihydroxyphenylalanine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Enzyme Inhibitors; Levodopa; Macaca fascicularis; MPTP Poisoning; Parkinson Disease, Secondary; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Presynaptic; Tyrosine | 2016 |
New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues.
Topics: Agaricales; Copper; Enzyme Inhibitors; Hydroxylation; Kinetics; Levodopa; Melanins; Molecular Docking Simulation; Monophenol Monooxygenase; Oligopeptides; Oxidation-Reduction; Oxidoreductases; Tyrosine | 2016 |
An Enzyme Cascade for Selective Modification of Tyrosine Residues in Structurally Diverse Peptides and Proteins.
Topics: Agaricales; Alkylation; Catalysis; Catechol O-Methyltransferase; Fungal Proteins; Hydroxylation; Levodopa; Monophenol Monooxygenase; Peptides; Peptides, Cyclic; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2016 |
Tyrosine Hydroxylation in Betalain Pigment Biosynthesis Is Performed by Cytochrome P450 Enzymes in Beets (Beta vulgaris).
Topics: Amino Acid Sequence; Arabidopsis; Beta vulgaris; Betacyanins; Betalains; Conserved Sequence; Cytochrome P-450 Enzyme System; Gene Expression; Gene Expression Profiling; Hydroxylation; Levodopa; Oxygenases; Phenotype; Phylogeny; Position-Specific Scoring Matrices; Tyrosine | 2016 |
Singlet oxygen generation during the oxidation of L-tyrosine and L-dopa with mushroom tyrosinase.
Topics: Agaricales; Electron Spin Resonance Spectroscopy; Indolequinones; Levodopa; Melanins; Monophenol Monooxygenase; Oxidation-Reduction; Piperidines; Singlet Oxygen; Superoxides; Tyrosine | 2016 |
Simultaneous estimation of levodopa, carbidopa and 3-oxymethyldopa in rat plasma using HPLC-ECD.
Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Electrochemical Techniques; Levodopa; Limit of Detection; Male; Rats; Rats, Wistar; Tyrosine | 2016 |
L-DOPA Reverses the Increased Free Amino Acids Tissue Levels Induced by Dopamine Depletion and Rises GABA and Tyrosine in the Striatum.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Forelimb; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Levodopa; Mice; Oxidopamine; Rotarod Performance Test; Taurine; Tyrosine | 2016 |
Novel post-translational oligomerization of peptidyl dehydrodopa model compound, 1,2-dehydro-N-acetyldopa methyl ester.
Topics: Agaricales; Levodopa; Models, Molecular; Molecular Structure; Monophenol Monooxygenase; Protein Processing, Post-Translational; Tyrosine | 2016 |
3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA.
Topics: Animals; Astrocytes; Catechol O-Methyltransferase Inhibitors; Catechols; Cells, Cultured; Corpus Striatum; Dihydroxyphenylalanine; Dopamine Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Glutathione; Levodopa; Mesencephalon; Neuroprotection; Neuroprotective Agents; Nitriles; Rats, Sprague-Dawley; Tyrosine | 2016 |
2-(4-Fluorophenyl)-quinazolin-4(3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism.
Topics: Enzyme Inhibitors; Halogenation; Kinetics; Levodopa; Molecular Docking Simulation; Monophenol Monooxygenase; Quinazolinones; Streptomyces; Tyrosine | 2016 |
Preloading with L-BPA, L-tyrosine and L-DOPA enhances the uptake of [
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Caco-2 Cells; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Humans; Levodopa; Mice; Neoplasms, Experimental; Phenylalanine; Propionates; Tyrosine; Up-Regulation | 2016 |
Effective L-Tyrosine Hydroxylation by Native and Immobilized Tyrosinase.
Topics: Agaricales; Air; Ascorbic Acid; Boron; Buffers; Diffusion; Enzyme Stability; Enzymes, Immobilized; Hydrogen-Ion Concentration; Hydroxylation; Levodopa; Monophenol Monooxygenase; Phosphates; Temperature; Tyrosine | 2016 |
Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase.
Topics: Agaricales; Catalytic Domain; Cations, Divalent; Cinnamates; Copper; Enzyme Inhibitors; Fungal Proteins; Kinetics; Levodopa; Molecular Docking Simulation; Monophenol Monooxygenase; Protein Binding; Spectrometry, Fluorescence; Tyrosine | 2017 |
Levodopa, placebo and rotigotine change biomarker levels for oxidative stress.
Topics: Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dipeptides; Dopamine Agents; Electrochemical Techniques; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Tetrahydronaphthalenes; Thiophenes; Time Factors; Tyrosine | 2017 |
Synthesis of Clovamide Analogues That Inhibit NO Production in Activated BV-2 Microglial Cells.
Topics: Animals; Anti-Inflammatory Agents; Caffeic Acids; Cell Line; Levodopa; Lipopolysaccharides; Mice; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Extracts; Structure-Activity Relationship; Tyrosine | 2017 |
Action of tyrosinase on caffeic acid and its n-nonyl ester. Catalysis and suicide inactivation.
Topics: Caffeic Acids; Carbon-13 Magnetic Resonance Spectroscopy; Catalysis; Esters; Kinetics; Levodopa; Molecular Docking Simulation; Monophenol Monooxygenase; Quinones; Substrate Specificity; Tyrosine | 2018 |
Involvement of phenoloxidase in browning during grinding of Tenebrio molitor larvae.
Topics: Amino Acid Sequence; Animals; Coleoptera; Diptera; Dopamine; Insect Proteins; Larva; Levodopa; Maillard Reaction; Monophenol Monooxygenase; Oxygen Consumption; Sequence Homology, Amino Acid; Tenebrio; Tyrosine | 2017 |
Post-translational incorporation of 3,4-dihydroxyphenylalanine into the C terminus of α-tubulin in living cells.
Topics: Animals; Cell Line, Tumor; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetulus; Levodopa; Mice; Microtubules; Neurons; Protein Processing, Post-Translational; Rats, Wistar; Tubulin; Tyrosine | 2018 |
Biochemical characterization and spatio-temporal analysis of the putative L-DOPA pathway in Mucuna pruriens.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dopamine; Gene Expression Profiling; Genes, Plant; Levodopa; Metabolic Networks and Pathways; Mucuna; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA; Transcriptome; Tyrosine | 2018 |
High sensitivity deep-UV LED-based z-cell photometric detector for capillary liquid chromatography.
Topics: Chromatography, Liquid; Levodopa; Octopamine; Phenylephrine; Photometry; Tyramine; Tyrosine; Ultraviolet Rays | 2018 |
An efficient colorimetric high-throughput screening method for synthetic activity of tyrosine phenol-lyase.
Topics: Colorimetry; Fusobacterium nucleatum; High-Throughput Screening Assays; Kinetics; Levodopa; Mutation; Substrate Specificity; Tyrosine; Tyrosine Phenol-Lyase | 2018 |
Time-dependent mucoadhesion of conjugated bioadhesive polymers.
Topics: Acrylic Resins; Adhesiveness; Adhesives; Animals; Butadienes; Hydrogen Bonding; Intestinal Mucosa; Intestine, Small; Levodopa; Maleic Anhydrides; Phenylalanine; Polymerization; Rats; Time Factors; Tissue Culture Techniques; Tyrosine | 2019 |
Simultaneous synthesis of l-DOPA and oxidation of d-amino acid by specific coupling of a peroxidase to d-amino acid oxidase.
Topics: Amino Acids; Catalysis; D-Amino-Acid Oxidase; Hydrogen Peroxide; Kinetics; Levodopa; Oxidation-Reduction; Peroxidase; Tyrosine | 2019 |
The study of inhibitory effects and mechanism of carboxylate chitooligomer on melanin, prepared by laccase/TEMPO system.
Topics: Agaricales; Chelating Agents; Chitin; Chitosan; Copper; Cyclic N-Oxides; Enzyme Inhibitors; Green Chemistry Technology; Laccase; Levodopa; Melanins; Models, Biological; Monophenol Monooxygenase; Oligosaccharides; Oxidation-Reduction; Skin Lightening Preparations; Tyrosine | 2019 |
Simultaneous determination of l‑DOPA, l‑tyrosine and uric acid by cysteic acid - modified glassy carbon electrode.
Topics: Carbon; Cysteic Acid; Electrochemical Techniques; Electrodes; Glass; Humans; Hydrogen-Ion Concentration; Levodopa; Polymerization; Tyrosine; Uric Acid | 2019 |
Alterations in the tyrosine and phenylalanine pathways revealed by biochemical profiling in cerebrospinal fluid of Huntington's disease subjects.
Topics: Adult; Aged; Biomarkers; Dopamine; Female; Humans; Huntington Disease; Levodopa; Male; Middle Aged; Phenylalanine; Thyroxine; Tyrosine | 2019 |
A role for foregut tyrosine metabolism in glucose tolerance.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Blood Glucose; Cell Line; Cross-Sectional Studies; Dopamine; Female; Gastrointestinal Tract; Glucose Tolerance Test; Homeostasis; Humans; Insulin; Insulin-Secreting Cells; Levodopa; Male; Nutrients; Obesity; Postprandial Period; Rats; Rats, Inbred Lew; Swine; Tyrosine; Tyrosine 3-Monooxygenase | 2019 |
Metabolic engineering of Escherichia coli BL21 (DE3) for de novo production of L-DOPA from D-glucose.
Topics: Bioreactors; Escherichia coli; Glucose; Glycerol; Levodopa; Metabolic Engineering; Mixed Function Oxygenases; Shikimic Acid; Tyrosine | 2019 |
Highly efficient biocatalytic synthesis of L-DOPA using in situ immobilized Verrucomicrobium spinosum tyrosinase on polyhydroxyalkanoate nano-granules.
Topics: Biocatalysis; Enzymes, Immobilized; Hydrogen-Ion Concentration; Levodopa; Nanoparticles; Nanotechnology; Oxidation-Reduction; Polyhydroxyalkanoates; Temperature; Tyrosine; Verrucomicrobia | 2019 |
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism.
Topics: Actinobacteria; Animals; Antiparkinson Agents; Bacterial Proteins; Decarboxylation; Dopamine; Enterococcus faecalis; Gastrointestinal Microbiome; Genome, Bacterial; HeLa Cells; Humans; Levodopa; Male; Metabolic Networks and Pathways; Mice, Inbred BALB C; Tyrosine; Tyrosine Decarboxylase | 2019 |
Palm Fruit Bioactives augment expression of Tyrosine Hydroxylase in the Nile Grass Rat basal ganglia and alter the colonic microbiome.
Topics: Alzheimer Disease; Animals; Basal Ganglia; Brain; Carbohydrates; Catalysis; Colon; Densitometry; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Gastrointestinal Microbiome; Gene Expression Regulation, Enzymologic; Humans; Hydroxylation; Immunohistochemistry; Levodopa; Male; Phoeniceae; Phytochemicals; Rats; Tyrosine; Tyrosine 3-Monooxygenase | 2019 |
Continuous Fluorometric Method for Determining the Monophenolase Activity of Tyrosinase on L-Tyrosine, through Quenching L-DOPA Fluorescence by Borate.
Topics: Borates; Fluorescence; Fluorometry; Levodopa; Molecular Structure; Monophenol Monooxygenase; Tyrosine | 2020 |
A Coculture Based Tyrosine-Tyrosinase Electrochemical Gene Circuit for Connecting Cellular Communication with Electronic Networks.
Topics: 4-Butyrolactone; Culture Media; Electrochemical Techniques; Electrodes; Gold; Levodopa; Monophenol Monooxygenase; Oxidation-Reduction; Plasmids; Pseudomonas aeruginosa; Pyocyanine; Quorum Sensing; Synthetic Biology; Tyrosine | 2020 |
Upcycling chitin-containing waste into organonitrogen chemicals via an integrated process.
Topics: Acetylglucosamine; Animals; Carbon; Chitin; Chitosan; Crustacea; Escherichia coli; Genetic Engineering; Glucose; Hydrolysis; Levodopa; Minerals; Nitrogen; Polymerization; Tyrosine; Waste Products | 2020 |
Purification and Biochemical Characterization of a Tyrosine Phenol-lyase from Morganella morganii.
Topics: Bacterial Proteins; Catalysis; Cells, Immobilized; Citrobacter freundii; Escherichia coli; Hydrogen-Ion Concentration; Ions; Kinetics; Levodopa; Molecular Weight; Morganella morganii; Protein Domains; Protein Structure, Secondary; Substrate Specificity; Temperature; Tyrosine; Tyrosine Phenol-Lyase | 2020 |
L-DOPA synthesis in Mucuna pruriens (L.) DC. is regulated by polyphenol oxidase and not CYP 450/tyrosine hydroxylase: An analysis of metabolic pathway using biochemical and molecular markers.
Topics: Animals; Catechol Oxidase; Cattle; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Female; Levodopa; Metabolic Networks and Pathways; Mucuna; Phylogeny; Tandem Mass Spectrometry; Tyrosine; Tyrosine 3-Monooxygenase | 2020 |
Oxidation of tyrosine: Antioxidant mechanism of l-DOPA disclosed.
Topics: Antioxidants; Levodopa; Oxidation-Reduction; Proteins; Tyrosine | 2021 |
Detection of 3-O-methyldopa in dried blood spots for neonatal diagnosis of aromatic L-amino-acid decarboxylase deficiency: The northeastern Italian experience.
Topics: Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Female; Humans; Infant, Newborn; Italy; Levodopa; Male; Neonatal Screening; Neurotransmitter Agents; Tandem Mass Spectrometry; Tyrosine | 2021 |
Analysis of Kojic Acid Derivatives as Competitive Inhibitors of Tyrosinase: A Molecular Modeling Approach.
Topics: Catalytic Domain; Enzyme Inhibitors; Humans; Levodopa; Melanins; Melanocytes; Melanoma; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Monophenol Monooxygenase; Pyrones; Skin Neoplasms; Structure-Activity Relationship; Tyrosine | 2021 |
Polyphenol oxidase (PPO) arm of catecholamine pathway catalyzes the conversion of
Topics: Catechol Oxidase; Catecholamines; Levodopa; Mucuna; Tyrosine | 2021 |
Effect of catechin and commercial preparation of green tea essence on the pharmacokinetics of l-dopa in rabbits.
Topics: Animals; Biological Availability; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, Liquid; Herb-Drug Interactions; Levodopa; Male; Rabbits; Reproducibility of Results; Tandem Mass Spectrometry; Tea; Tyrosine | 2021 |
Bicomponent Coassembled Hydrogel as a Template for Selective Enzymatic Generation of DOPA.
Topics: Hydrogels; Levodopa; Monophenol Monooxygenase; Oxidation-Reduction; Tyrosine | 2021 |
Production of 3,4-dihydroxy-L-phenylalanine using novel tyrosinases from Bacillus megaterium.
Topics: Bacillus megaterium; Levodopa; Melanins; Monophenol Monooxygenase; Tyrosine | 2022 |
Rifampicin is not an inhibitor of tyrosinase.
Topics: Kinetics; Levodopa; Monophenol Monooxygenase; Oxidation-Reduction; Rifampin; Tyrosine | 2022 |
Monophenolase assay using excitation-emission matrix fluorescence and ELMAN neural network assisted by whale optimization algorithm.
Topics: Agaricales; Algorithms; Animals; Enzyme Inhibitors; Fluorescence; Kinetics; Levodopa; Monophenol Monooxygenase; Neural Networks, Computer; Oxidoreductases; Tyrosine; Whales | 2022 |
Chromosomal-level genome of velvet bean (Mucuna pruriens) provides resources for L-DOPA synthetic research and development.
Topics: Catechol Oxidase; Chromosomes; Dopamine; Levodopa; Mucuna; Pharmaceutical Preparations; Research; Tyrosine | 2022 |
Improved natural melanin production by Aspergillus nidulans after optimization of factors involved in the pigment biosynthesis pathway.
Topics: Antioxidants; Aspergillus nidulans; Levodopa; Melanins; Tyrosine | 2022 |
Syntheses and Biofilm Reducing Effects of l-Dopa-Derived Analogues of the Fungal Macrocidins A and Z.
Topics: Anti-Bacterial Agents; Biofilms; Levodopa; Structure-Activity Relationship; Tyrosine | 2023 |
Oxidation of baicalein by tyrosinase and by o-quinones.
Topics: Flavanones; Kinetics; Levodopa; Monophenol Monooxygenase; Oxidation-Reduction; Tyrosine | 2023 |
AdpA
Topics: Bacterial Proteins; Levodopa; Lincomycin; Melanins; Secondary Metabolism; Tyrosine | 2023 |
Comparison of betalain compounds in two Beta vulgaris var. cicla and BvCYP76AD27 function identification in betalain biosynthesis.
Topics: Beta vulgaris; Betalains; Levodopa; Plant Leaves; Saccharomyces cerevisiae; Tyrosine | 2023 |
Enzymatic Phosphorylation of Oxidized Tyrosine Residues.
Topics: Levodopa; Peptides; Phosphorylation; Protein Processing, Post-Translational; Tandem Mass Spectrometry; Tyrosine | 2023 |
Ability of Latilactobacillus curvatus FAM25164 to produce tryptamine: Identification of a novel tryptophan decarboxylase.
Topics: Amino Acids; Aromatic-L-Amino-Acid Decarboxylases; Escherichia coli; Lactobacillus; Levodopa; Phenylalanine; Tryptamines; Tyrosine | 2023 |
Innovative electrochemical platform for the simultaneous determination of L-DOPA and L-tyrosine using layer-by-layer assembled L-proline-linked nanodiamonds on printed graphene.
Topics: Graphite; Humans; Levodopa; Nanodiamonds; Poly A; Proline; Reproducibility of Results; Tyrosine | 2023 |