levodopa has been researched along with sapropterin in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (27.45) | 18.7374 |
| 1990's | 13 (25.49) | 18.2507 |
| 2000's | 14 (27.45) | 29.6817 |
| 2010's | 9 (17.65) | 24.3611 |
| 2020's | 1 (1.96) | 2.80 |
| Authors | Studies |
|---|---|
| Kohsaka, S; Nagatsu, T; Tsuzaki, N; Uchida, K | 1 |
| Hyland, K; Surtees, R | 1 |
| Dissing, IC; Gerdes, AM; Güttler, F; Lou, H; Lykkelund, C; Pakkenberg, H; Rasmussen, V | 1 |
| Araki, K; Matsuo, N; Niederwieser, A; Tanaka, Y; Tsuchiya, Y; Tsuzaki, S | 1 |
| Hayashi, T; Nakane, A; Naruse, H; Takesada, M; Yamazaki, K | 1 |
| Arévalo, R; Castro, R; Palarea, MD; Pérez, J; Rodríguez, M | 1 |
| Nagatsu, T | 1 |
| Ishida, A; Kobayashi, Y; Takada, G; Takai, K; Toyoshima, I | 1 |
| Higashi, O; Ishida, A; Kobayashi, Y; Takada, G; Takai, K; Toyoshima, I | 1 |
| Fujita, N; Miyatake, T; Nakajima, T; Ohwada, M; Tanaka, K | 1 |
| Blonder, J; Cohen, BE; Normand, M; Peled, I; Quint, J; Szeinberg, A | 1 |
| Mann, SP; Sharman, DF | 1 |
| Bullard, WP; Capson, TL | 1 |
| Burton, K; Calne, DB | 1 |
| Boespflug, O; Demeocq, F; Guyon, A; Malpuech, G; Piton, A; Vanlieferinghen, P | 1 |
| Curtius, HC; Endres, W; Niederwieser, A; Ohrt, B; Schaub, J; Wang, M | 1 |
| Callaghan, S; Gardner, ML; Lindsey, NJ; Schallreuter-Wood, KU; Wood, JM | 1 |
| Koshimura, K; Masaki, T; Miwa, S; Ohue, T; Takagi, Y; Watanabe, Y | 1 |
| Hossain, MA; Weiner, N | 1 |
| Blau, N; Dhondt, JL | 1 |
| Haavik, J | 1 |
| Carlsson, A; Fasth, KJ; Hartvig, P; Långström, B; Neu, H; Sonesson, C; Tedroff, J; Torstenson, R; Waters, N | 1 |
| Bieglmayer, C; Birnbacher, R; Blau, N; Frisch, H; Scheibenreiter, S; Waldhauser, F | 1 |
| Kang, UJ; Leff, SE; Mandel, RJ; Rendahl, KG; Spratt, SK | 1 |
| Bebin, EM; Fryburg, JS; Furukawa, Y; Hyland, K; Jacobson, RD; Kish, SJ; Shimadzu, M; Trugman, JM; Wilson, WG | 1 |
| Anastasiadis, PZ; Bezin, L; Levine, RA; Nygaard, TG | 1 |
| Jeon, BS; Jeong, JM; Lee, MC; Park, SS | 1 |
| Chiang, SH; Hsiao, KJ; Liu, TT; Wu, SJ | 1 |
| Chiang, SC; Chien, YH; Chiu, YN; Chou, SP; Chu, SY; Huang, A; Hwu, WL; Lin, JM; Wang, TR | 1 |
| Maass, A; Moser, A; Scholz, J | 1 |
| Arnold, LA; Egami, K; Hyland, K; Jinnah, HA; Kasim, S | 1 |
| Chien, YH; Hwu, WL; Liu, HM; Peng, SS; Tseng, WY | 1 |
| Blau, N; Connolly, MB; Demos, MK; Hyland, K; Lillquist, Y; Makhseed, N; Vallance, HD; Waters, PJ | 1 |
| Cheng, LY; Chiu, PC; Hsiao, KJ; Lee, NC; Liu, TT; Niu, DM | 1 |
| Furukawa, Y | 1 |
| Abreu-González, P; Afonso-Oramas, D; Barroso-Chinea, P; Cruz-Muros, I; González, MC; González-Hernández, T | 1 |
| Chang, M; Fu, GX; He, C; Hsiao, KJ; Li, XW; Liu, TT; Shen, M; Shen, S; Wang, L; Yu, WM; Zhao, SP | 1 |
| Hanajima, R; Nomura, Y; Segawa, M; Ugawa, Y | 1 |
| Kato, M; Kondo, H; Matsuo, N; Muramatsu, T; Nukazawa, T; Okano, Y; Saito, F; Sato, S; Shintaku, H; Tanaka, Y | 1 |
| Kanazawa, M; Kitani, Y; Kohno, Y; Ogawa, A; Shintaku, H; Takayanagi, M | 1 |
| Abada, M; Bouteiller, D; Brice, A; Camuzat, A; Castelnau, P; Cazeneuve, C; Chabrol, B; Clot, F; Damier, P; Doummar, D; Durr, A; Fedirko, E; Gil, R; Grabli, D; Hutchinson, M; Landrieu, P; LeGuern, E; Nguyen, K; Picard, F; Ponsot, G; Roze, E; Sân, C; Thobois, S; Toutain, A; Vidailhet, M; Ward, AJ | 1 |
| Luthra, PM; Singh, S | 1 |
| Allen, GF; Clayton, PT; Footitt, EJ; Heales, SJ; Mills, PB; Oppenheim, M | 1 |
| Concolino, D; Mussa, A; Ponzone, A; Porta, F; Spada, M | 1 |
| Ohwada, M; Shintaku, H | 1 |
| Blau, N; Hoffmann, GF; Kühn, AA; Opladen, T | 1 |
| Gorska, KI; Haruki, H; Johnsson, K; Pedersen, MG; Pojer, F | 1 |
| Cao, Z; Han, B; Liu, Y; Zhu, W; Zou, H | 1 |
| Alp, NJ; Channon, KM; Crabtree, MJ; Douglas, G; Gross, SS; Hale, AB; Hansler, A; Lygate, CA; Ryan, BJ; Watschinger, K | 1 |
| Fukuda, K | 1 |
| Cherian, A; Divya, KP; Paramasivan, NK | 1 |
5 review(s) available for levodopa and sapropterin
| Article | Year |
|---|---|
[Current perspectives in the treatment of Parkinson disease].
Topics: Biopterins; Brain Chemistry; Dopamine; Dopamine Antagonists; Humans; Levodopa; Neurotransmitter Agents; Parkinson Disease; Synaptic Transmission; Tyrosine 3-Monooxygenase | 1985 |
[Pathogenic substances in Parkinson disease and new therapeutics considering the etiologic mechanism].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biopterins; Dopamine Agents; Droxidopa; Humans; Levodopa; Nerve Tissue; Parkinson Disease; Pyridines; Serine | 1988 |
Pharmacology of Parkinson's disease.
Topics: Amantadine; Antidepressive Agents; Antiparkinson Agents; Biopterins; Dopamine; Histamine H1 Antagonists; Humans; Levodopa; Monoamine Oxidase Inhibitors; Norepinephrine; Parasympatholytics; Parkinson Disease | 1984 |
Tetrahydrobiopterin metabolism and GTP cyclohydrolase I mutations in L-dopa-responsive dystonia.
Topics: Biopterins; Dopamine Agents; Dystonia; GTP Cyclohydrolase; Humans; Levodopa; Mutation | 1998 |
Dopa-responsive dystonia, DRD-plus and DRD look-alike: a pragmatic review.
Topics: Alcohol Oxidoreductases; Biopterins; Dopamine; Dystonia; Dystonic Disorders; Humans; Levodopa | 2021 |
3 trial(s) available for levodopa and sapropterin
| Article | Year |
|---|---|
Tetrahydrobiopterin and Parkinson's disease.
Topics: Adult; Antiparkinson Agents; Benserazide; Biopterins; Clinical Trials as Topic; Drug Combinations; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
[Metabolic changes in aromatic amino acids and monoamines in infantile autism and development of new treatment related to the finding].
Topics: 5-Hydroxytryptophan; Amino Acids; Autistic Disorder; Biogenic Monoamines; Biopterins; Carbon Isotopes; Child; Child, Preschool; Clinical Trials as Topic; Deuterium; Double-Blind Method; Humans; Levodopa; Phenylalanine; Tryptophan | 1989 |
Atypical phenylketonuria due to biopterin deficiency. Early treatment with tetrahydrobiopterin and neurotransmitter precursors, trials of monotherapy.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Clinical Trials as Topic; Humans; Infant; Levodopa; Male; Phenylketonurias; Pteridines | 1982 |
43 other study(ies) available for levodopa and sapropterin
| Article | Year |
|---|---|
Tetrahydrobiopterin-dependent functional recovery in 6-hydroxydopamine-treated rats by intracerebral grafting of fibroblasts transfected with tyrosine hydroxylase cDNA.
Topics: Animals; Apomorphine; Behavior, Animal; Biopterins; Brain; Cell Line, Transformed; DNA; Female; Fibroblasts; Levodopa; Oxidopamine; Rats; Rats, Wistar; Stereotyped Behavior; Transfection; Tyrosine 3-Monooxygenase | 1992 |
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans.
Topics: Adolescent; Akinetic Mutism; Biopterins; Child, Preschool; Humans; Infant; Levodopa; Methionine; NADH, NADPH Oxidoreductases; Phenylketonurias; Pyridoxine; S-Adenosylmethionine; Tetrahydrofolates; Tyrosine | 1990 |
On-off phenomenon in a child with tetrahydrobiopterin deficiency due to 6-pyruvoyl tetrahydropterin synthase deficiency (BH4 deficiency).
Topics: Administration, Oral; Alcohol Oxidoreductases; Biopterins; Carbidopa; Child; Female; Humans; Levodopa; Phosphorus-Oxygen Lyases; Psychomotor Performance | 1989 |
Effect of tetrahydrobiopterin and 5-hydroxytryptophan on hereditary progressive dystonia with marked diurnal fluctuation: a suggestion of the serotonergic system involvement.
Topics: 5-Hydroxytryptophan; Adult; Biopterins; Child; Circadian Rhythm; Dystonia; Female; Humans; Levodopa | 1988 |
[Serotonergic disturbance in hereditary progressive dystonia--clinical effects of tetrahydrobiopterin and 5-hydroxytryptophan].
Topics: 5-Hydroxytryptophan; Adult; Biopterins; Child; Dopamine; Dystonia; Female; Humans; Levodopa; Neurons; Serotonin | 1988 |
[A deficiency of dihydrobiopterin synthesis. The effects of L-dopa, 5HTP and BH4].
Topics: 5-Hydroxytryptophan; Biopterins; Drug Therapy, Combination; Humans; Levodopa; Male; Middle Aged | 1988 |
Malignant phenylketonuria due to defective synthesis of dihydrobiopterin.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Drug Combinations; Female; Humans; Infant, Newborn; Levodopa; Male; Nervous System Diseases; Phenylalanine; Phenylketonurias; Pteridines; Tyrosine | 1985 |
Changes associated with early weaning in the activity of tyrosine hydroxylase in the caudate nucleus of the piglet.
Topics: Animals; Behavior, Animal; Biopterins; Caudate Nucleus; Kinetics; Levodopa; Swine; Time Factors; Tyrosine 3-Monooxygenase; Weaning | 1983 |
Steady-state kinetics of bovine striatal tyrosine hydroxylase.
Topics: Animals; Biopterins; Cattle; Corpus Striatum; Dopamine; Kinetics; Levodopa; Oxygen; Substrate Specificity; Tyrosine; Tyrosine 3-Monooxygenase | 1983 |
[Malignant phenylketonuria caused by biopterin synthetase deficiency. Study of neuromediator catabolites in the cerebrospinal fluid during treatment].
Topics: Alcohol Oxidoreductases; Biopterins; Carbidopa; Follow-Up Studies; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Levodopa; Male; Neurotransmitter Agents; Phenylketonurias; Serotonin | 1984 |
A specific tetrahydrobiopterin binding domain on tyrosinase controls melanogenesis.
Topics: Amino Acid Sequence; Animals; Basidiomycota; Binding Sites; Biopterins; Humans; Hydro-Lyases; Kinetics; Levodopa; Melanins; Mice; Molecular Sequence Data; Monophenol Monooxygenase; Phenylalanine Hydroxylase; Ranidae; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine | 1995 |
Enhancement of acetylcholine release in the hippocampus by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin is mediated by 5-hydroxytryptamine.
Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Biogenic Monoamines; Biopterins; Chromatography, High Pressure Liquid; Dialysis; Fenclonine; Hippocampus; Levodopa; Male; Methyltyrosines; Rats; Rats, Wistar; Serotonin; Tyrosine 3-Monooxygenase | 1993 |
Dopaminergic functional supersensitivity: effects of chronic L-dopa and carbidopa treatment in an animal model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biopterins; Brain Diseases; Carbidopa; Corpus Striatum; Cyclic AMP; Disease Models, Animal; Dopamine; Dopamine D2 Receptor Antagonists; Homovanillic Acid; Levodopa; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred F344; Receptors, Dopamine D1; Receptors, Dopamine D2; Sensitivity and Specificity; Substantia Nigra; Time Factors | 1993 |
Tetrahydrobiopterin deficiency and an international database of patients.
Topics: 5-Hydroxytryptophan; Alcohol Oxidoreductases; Biomarkers; Biopterins; Carbidopa; Child; Dihydropteridine Reductase; GTP Cyclohydrolase; Humans; Hydro-Lyases; Information Systems; Levodopa; Metabolism, Inborn Errors; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases; Pterins; Registries | 1993 |
L-DOPA is a substrate for tyrosine hydroxylase.
Topics: Antioxidants; Basidiomycota; Biopterins; Dihydroxyphenylalanine; Humans; Kinetics; Levodopa; Monophenol Monooxygenase; Recombinant Proteins; Substrate Specificity; Tyrosine 3-Monooxygenase | 1997 |
Effects of the substituted (S)-3-phenylpiperidine (-)-OSU6162 on PET measurements in subhuman primates: evidence for tone-dependent normalization of striatal dopaminergic activity.
Topics: Animals; Biopterins; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Female; Levodopa; Macaca mulatta; Piperidines; Reference Values; Tomography, Emission-Computed; Tyrosine | 1998 |
Hyperprolactinemia, a tool in treatment control of tetrahydrobiopterin deficiency: endocrine studies in an affected girl.
Topics: Adolescent; Biopterins; Carbidopa; Delayed-Action Preparations; Drug Combinations; Female; Follicle Stimulating Hormone; Human Growth Hormone; Humans; Hydrocortisone; Hyperprolactinemia; Insulin; Levodopa; Luteinizing Hormone; Melatonin; Phenylketonurias; Phosphorus-Oxygen Lyases; Prolactin | 1998 |
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase.
Topics: 3T3 Cells; Animals; Antioxidants; Antiparkinson Agents; Apomorphine; Behavior, Animal; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Fibroblasts; Gene Expression Regulation, Enzymologic; Genetic Therapy; Gliosarcoma; GTP Cyclohydrolase; Humans; Levodopa; Male; Mice; Microdialysis; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Recombinant Fusion Proteins; Retroviridae; Transformation, Genetic; Transgenes; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1998 |
Dystonia with motor delay in compound heterozygotes for GTP-cyclohydrolase I gene mutations.
Topics: Adolescent; Adult; Antioxidants; Biopterins; Child; DNA; Drug Therapy, Combination; Dystonia; Female; Frameshift Mutation; Humans; Levodopa; Male; Middle Aged; Pedigree; Point Mutation | 1998 |
Dopa-responsive dystonia: a syndrome of selective nigrostriatal dopamine deficiency.
Topics: Adolescent; Adult; Age of Onset; Biopterins; Child; Cocaine; Corpus Striatum; DNA Mutational Analysis; Dopamine; Dopamine Agents; Dystonia; Female; GTP Cyclohydrolase; Humans; Iodine Radioisotopes; Levodopa; Male; Mutation; Neopterin; Pedigree; Substantia Nigra; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 1998 |
Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese.
Topics: 5-Hydroxytryptophan; Biopterins; Diagnosis, Differential; Dihydropteridine Reductase; Female; Genetic Carrier Screening; Humans; Incidence; Levodopa; Mass Screening; Mutation; Phenylketonurias; Phosphorus-Oxygen Lyases; Pregnancy; Prenatal Diagnosis; Taiwan; Treatment Outcome | 2001 |
Treatment and outcome of Taiwanese patients with 6-pyruvoyltetrahydropterin synthase gene mutations.
Topics: 5-Hydroxytryptophan; Base Sequence; Biopterins; DNA Mutational Analysis; Founder Effect; Humans; Infant, Newborn; Intelligence; Levodopa; Mutation; Neonatal Screening; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases; Taiwan; Treatment Outcome | 2001 |
Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase.
Topics: Amino Acid Sequence; Animals; Biopterins; Catalytic Domain; Dopamine; Humans; Levodopa; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Phenylalanine; Phenylalanine Hydroxylase; Protein Binding; Rats; Sequence Alignment; Substrate Specificity; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease.
Topics: Animals; Biopterins; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phenylalanine; Tyrosine | 2004 |
Diffusion tensor images in children with early-treated, chronic, malignant phenylketonuric: correlation with intelligence assessment.
Topics: 5-Hydroxytryptophan; Axons; Biopterins; Brain Damage, Chronic; Cerebral Cortex; Child; Child, Preschool; Combined Modality Therapy; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Dominance, Cerebral; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Intelligence; Levodopa; Male; Neonatal Screening; Nerve Fibers, Myelinated; Phenylalanine; Phenylketonurias; Pregnancy | 2004 |
6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Cerebral Palsy; Child; Developmental Disabilities; Diagnostic Errors; Dopamine Agents; Female; Humans; Levodopa; Movement Disorders; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases; Seizures | 2005 |
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Asian People; Biopterins; Child; Child, Preschool; China; Female; Follow-Up Studies; Humans; Infant; Intellectual Disability; Levodopa; Male; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases; Seizures; Time Factors | 2006 |
[Dopa-responsive dystonia: clinical, genetic, and biochemical studies].
Topics: Biopterins; Child; Chromosomes, Human, Pair 14; Dystonic Disorders; GTP Cyclohydrolase; Humans; Levodopa; Tyrosine 3-Monooxygenase | 2006 |
Tetrahydrobiopterin stimulates L-DOPA release from striatal tissue.
Topics: alpha-Methyltyrosine; Animals; Biopterins; Corpus Striatum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; In Vitro Techniques; Levodopa; Male; Melatonin; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Pterins; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2006 |
[Study on tetrahydrobiopterin deficiency in Northern Chinese population].
Topics: 5-Hydroxytryptophan; Asian People; Biopterins; Child, Preschool; China; Dihydropteridine Reductase; Humans; Infant; Levodopa; Phenylalanine; Phenylketonurias; Phosphorus-Oxygen Lyases | 2006 |
Intracortical inhibition of the motor cortex in Segawa disease (DYT5).
Topics: Adult; Basal Ganglia; Biopterins; Brain Diseases, Metabolic; Diagnosis, Differential; Dopamine; Dopamine Agents; Dystonic Disorders; Evoked Potentials, Motor; Female; gamma-Aminobutyric Acid; GTP Cyclohydrolase; Humans; Interneurons; Levodopa; Male; Middle Aged; Motor Cortex; Muscle, Skeletal; Neural Inhibition; Neural Pathways; Phenotype; Transcranial Magnetic Stimulation | 2007 |
Early initiation of L-dopa therapy enables stable development of executive function in tetrahydrobiopterin (BH4) deficiency.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Biopterins; Child; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Neuropsychological Tests; Phosphorus-Oxygen Lyases; Problem Solving; Treatment Outcome; Wechsler Scales | 2007 |
A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels.
Topics: 5-Hydroxytryptophan; Biomarkers; Biopterins; Brain Diseases, Metabolic; Child, Preschool; Dopamine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Homovanillic Acid; Humans; Hypothalamo-Hypophyseal System; Levodopa; Phosphorus-Oxygen Lyases; Predictive Value of Tests; Prolactin | 2008 |
Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia.
Topics: Adolescent; Adult; Age of Onset; Alcohol Oxidoreductases; Biopterins; Child; Child, Preschool; Dopamine; Dopamine Agents; Dystonic Disorders; Female; GTP Cyclohydrolase; Heterozygote; Humans; Levodopa; Male; Middle Aged; Point Mutation; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases; Young Adult | 2009 |
Identification and optimization of tyrosine hydroxylase activity in Mucuna pruriens DC. var. utilis.
Topics: Biocatalysis; Biopterins; Blotting, Western; Cations, Divalent; Chromatography, High Pressure Liquid; Dopamine; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Hydrogen-Ion Concentration; Hydroxylation; Kinetics; Levodopa; Mucuna; Organ Specificity; Plant Leaves; Substrate Specificity; Temperature; Time Factors; Tyrosine 3-Monooxygenase | 2010 |
Pyridoxal 5'-phosphate in cerebrospinal fluid; factors affecting concentration.
Topics: Adolescent; Adult; Biopterins; Child; Child, Preschool; Cysteine; Epilepsy; False Positive Reactions; Female; Free Radicals; Humans; Infant; Infant, Newborn; Levodopa; Male; Metabolism, Inborn Errors; Middle Aged; Nervous System Diseases; Oxygen; Pyridoxal Phosphate; Reference Values; Reproducibility of Results; Sulfites; Tetrahydrofolates | 2011 |
Dopamine agonists in dihydropteridine reductase deficiency.
Topics: Adult; Behavior; Benzothiazoles; Biopterins; Child; Dihydropteridine Reductase; Dopamine; Dopamine Agonists; Humans; Levodopa; Locomotion; Male; Phenylketonurias; Phosphorus-Oxygen Lyases; Pramipexole; Prolactin; Young Adult | 2012 |
Long-term follow-up of tetrahydrobiopterin therapy in patients with tetrahydrobiopterin deficiency in Japan.
Topics: Adolescent; Adult; Biopterins; Child; Child, Preschool; Developmental Disabilities; Dopamine Agents; Drug Therapy, Combination; Female; Humans; Japan; Levodopa; Longitudinal Studies; Male; Phenylketonurias; Product Surveillance, Postmarketing; Retrospective Studies; Young Adult | 2013 |
Pitfalls in phenylalanine loading test in the diagnosis of dopa-responsive dystonia.
Topics: Administration, Oral; Adult; Biopterins; Diagnosis, Differential; Dystonia; Dystonic Disorders; Female; Humans; Levodopa; Metabolism, Inborn Errors; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Psychomotor Disorders; Tyrosine | 2013 |
Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.
Topics: 5-Hydroxytryptophan; Adult; Alcohol Oxidoreductases; Anti-Infective Agents; Biopterins; Cell Line; Central Nervous System; Crystallography, X-Ray; Fibroblasts; Humans; Levodopa; NADP; Nausea; Pneumonia, Pneumocystis; Protein Conformation; Structure-Activity Relationship; Sulfamethoxazole; Trimethoprim, Sulfamethoxazole Drug Combination; Vomiting | 2013 |
Diagnosis, treatment and follow-up of patients with tetrahydrobiopterin deficiency in Shandong province, China.
Topics: 5-Hydroxytryptophan; Biopterins; Child, Preschool; China; Follow-Up Studies; Genotype; Humans; Infant; Infant, Newborn; Intelligence Tests; Levodopa; Mutation; Neopterin; Phenylalanine; Phenylketonurias; Treatment Outcome | 2015 |
A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
Topics: Animals; Biopterins; Chromatography, High Pressure Liquid; Embryo, Mammalian; Embryonic Development; Female; Gene Expression Regulation, Developmental; GTP Cyclohydrolase; Immunohistochemistry; Levodopa; Male; Mass Spectrometry; Metabolomics; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2015 |
Integrated theory to unify status among schizophrenia and manic depressive illness.
Topics: 5-Hydroxytryptophan; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Biopterins; Bipolar Disorder; Blood-Brain Barrier; Depression; Depression, Postpartum; Dopamine; Female; Hallucinations; Humans; Kynurenic Acid; Levodopa; Male; Neuroleptic Malignant Syndrome; Neurotransmitter Agents; Paranoid Disorders; Premenstrual Syndrome; Schizophrenia; Seasonal Affective Disorder; Serotonin; Serotonin Syndrome; Tyrosine | 2015 |