Page last updated: 2024-08-17

levodopa and s-adenosylmethionine

levodopa has been researched along with s-adenosylmethionine in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (39.53)	18.7374
1990's	10 (23.26)	18.2507
2000's	11 (25.58)	29.6817
2010's	4 (9.30)	24.3611
2020's	1 (2.33)	2.80

Authors

Authors	Studies
Akamatsu, W; Fujimaki, M; Hatano, T; Hattori, N; Ishikawa, KI; Nojiri, S; Oyama, G; Saiki, S; Takeshige-Amano, H; Ueno, SI; Yamaguchi, A	1
Charlton, CG; Way, EL	1
Bidard, JN; Cronenberger, L; Fonlupt, P; Pacheco, H	1
Matthysse, S	1
Bidard, JN; Cronenberger, L	1
Baldessarini, RJ; Lipinski, JF; Stramentinoli, G	1
Harik, SI	1
Ordonez, LA; Wurtman, RJ	1
Baldessarini, RJ	1
Agnoli, A; Carolei, A; Cerbo, R; Meco, G; Ruggieri, S; Zamponi, A	1
Charlton, CG; Crowell, B	2
Hyland, K; Surtees, R	1
Black, MJ; Brandt, RB	1
Munro, HN; Roel, LE; Weiss, BF; Wurtman, RJ	1
Algeri, S; Catto, E; Stramentinoli, G	1
Fuller, RW; Hemrick-Leucke, SK; Perry, KW	1
Gibson, J; Van der Westhuyzen, J	1
Claverie, N; Danzin, C; Huot-Olivier, S; Palfreyman, MG; Wagner, J	1
Fuller, RW; Hemrick-Luecke, SK; Perry, KW	1
Bone, AH; Taufek, HR	1
Fukazawa, H; Funaki, T; Kuruma, I; Onodera, H; Tagami, C; Tsukamoto, Y; Ushiyama, N	1
Julkunen, I; Lotta, T; Melén, K; Taskinen, J; Tilgmann, C; Ulmanen, I; Vidgren, J	1
Da Prada, M; Dingemanse, J; Zürcher, G	1
Benson, R; Charlton, C; Crowell, B; Doonquah, K; Hill, B	1
Benson, R; Charlton, CG; Crowell, BG; Shockley, D	1
Joseph, JA; Miller, JW; Nadeau, MR; Selhub, J; Shukitt-Hale, B; Villalobos-Molina, R	1
Aquilonius, SM; Cheng, H; Ekblom, J; Gomes-Trolin, C; Löfberg, C; Oreland, L; Steinberg, A	1
Bareiss, M; Blessing, H; Carvey, P; Jankowski, S; Ling, ZD; Schwarz, J; Storch, A	1
Charlton, CG; Liu, XX; Wilson, K	1
Bottiglieri, T; Bressman, S; Di Rocco, A; Prikhojan, A; Rempel, N; Werner, P; Yahr, MD	1
Fowler, B; Hauptmann, B; Kuhn, W; Müller, T; Woitalla, D	1
Charlton, CG; Lamango, N; Latinwo, L; Lee, ES; Liu, XX; Zhao, WQ	1
Bareiss, M; Blessing, H; Schwarz, J; Storch, A; Zettlmeisl, H	1
Decker, PA; Dousa, MK; Muenter, MD; Offord, KP; Tyce, GM; Weinshilboum, RM	1
Di Rocco, A; Werner, P	2
Diaz-Arrastia, R; O'Suilleabhain, P	1
Brosnan, JT; Brosnan, ME; Jacobs, RL; Stead, LM	1
Barone, P; De Bonis, ML; Galletti, P; Ingrosso, D; Longo, K; Pellecchia, MT; Russo, A; Salvatore, A; Tedeschi, G; Tessitore, A; Zappia, V	1
Müller, T	1
Allemann, O; Bissantz, C; Burgy, G; Diederich, F; Ehler, A; Ellermann, M; Grünstein, D; Jakob-Roetne, R; Lerner, C; Paulini, R; Rudolph, MG; Stihle, M; Tissot, H	1
Chen, X; Gong, Z; Jiang, Y; Qian, L; Xu, Z; Yan, Q; Yan, Y; Zeng, S	1

Reviews

3 review(s) available for levodopa and s-adenosylmethionine

Article	Year
Biological transmethylation involving S-adenosylmethionine: development of assay methods and implications for neuropsychiatry. International review of neurobiology, 1975, Volume: 18 Topics: Acetylserotonin O-Methyltransferase; Animals; Apomorphine; Blood Platelets; Brain; Histamine; Humans; Leukemia; Levodopa; Methionine; Methionine Adenosyltransferase; Methyltransferases; Monoamine Oxidase Inhibitors; Pyrogallol; Rabbits; Rats; S-Adenosylmethionine; Schizophrenia; Serotonin; Tetrahydrofolates	1975
Methylation demand and homocysteine metabolism. Advances in enzyme regulation, 2004, Volume: 44 Topics: Animals; Homocysteine; Humans; Levodopa; Methionine Adenosyltransferase; Methylation; Methyltransferases; Niacin; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylmethionine	2004
Catechol-O-methyltransferase enzyme: cofactor S-adenosyl-L-methionine and related mechanisms. International review of neurobiology, 2010, Volume: 95 Topics: Antiparkinson Agents; Catechol O-Methyltransferase; Humans; Levodopa; Parkinson Disease; S-Adenosylmethionine	2010

Other Studies

40 other study(ies) available for levodopa and s-adenosylmethionine

Article	Year
Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease. Cells, 2018, 12-29, Volume: 8, Issue:1 Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Carnitine; Fatty Acids; Female; Humans; Levodopa; Male; Mental Status and Dementia Tests; Metabolome; Middle Aged; Mitochondria; Oxidation-Reduction; Parkinson Disease; Pilot Projects; Severity of Illness Index; Zonisamide	2018
Tremor induced by S-adenosyl-L-methionine: possible relation to L-dopa effects. The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:12 Topics: Animals; Brain Chemistry; Injections, Intraventricular; Levodopa; Mice; Mice, Inbred ICR; S-Adenosylmethionine; Tremor	1978
[Effect of S-adenosyl-L-methionine on the cerebral and peripheral metabolism of L-dopa]. Archives internationales de physiologie et de biochimie, 1978, Volume: 86, Issue:4 Topics: Animals; Biological Transport; Brain; Catecholamines; Dopamine; Levodopa; Male; Methyldopa; Norepinephrine; Normetanephrine; Rats; S-Adenosylmethionine; Tissue Distribution	1978
On lowering S-adenosylmethionine. Monographien aus dem Gesamtgebiete der Psychiatrie, 1978, Volume: 18 Topics: Animals; Levodopa; Liver; Methylation; Methyltransferases; Niacinamide; Norepinephrine; Rats; S-Adenosylmethionine	1978
[Fluorimetric assay of 3-o-methyldopamine and 4-0-methyldopamine in rat urine and o-methylation of dopamine]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1977, Jan-31, Volume: 284, Issue:5 Topics: Animals; Deoxyepinephrine; Dopamine; Levodopa; Male; Methylation; Rats; S-Adenosylmethionine; Spectrometry, Fluorescence	1977
Methylation hypothesis. Archives of general psychiatry, 1979, Volume: 36, Issue:3 Topics: Adult; Animals; Brain; Dose-Response Relationship, Drug; Female; Humans; Levodopa; Liver; Lung; Male; Methionine; Methylation; Mice; Rabbits; Rats; S-Adenosylmethionine; Tryptamines	1979
Effects of L-dopa on putrescine levels in the brain and the liver of the rat. European journal of pharmacology, 1979, Mar-01, Volume: 54, Issue:3 Topics: Amino Acids; Animals; Brain Chemistry; Dihydroxyphenylalanine; Hypophysectomy; Levodopa; Liver; Male; Ornithine Decarboxylase; Putrescine; Rats; S-Adenosylmethionine; Spermidine; Time Factors	1979
Effects of exogenous L-dopa on the metabolism of methionine and S-adenosylmethionine in the brain. Monographien aus dem Gesamtgebiete der Psychiatrie, 1978, Volume: 18 Topics: Animals; Brain; Levodopa; Methionine; Methylation; Rats; S-Adenosylmethionine	1978
[Animal stereotypy and transmethylation of cerebral amines]. Bollettino della Societa italiana di biologia sperimentale, 1975, Apr-15, Volume: 51, Issue:7 Topics: Amines; Amphetamine; Animals; Apomorphine; Brain; Levodopa; Movement Disorders; Piribedil; Rats; S-Adenosylmethionine	1975
Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:2 Topics: Animals; Behavior, Animal; Histocytochemistry; Injections, Intraventricular; Levodopa; Male; Nerve Degeneration; Parkinson Disease, Secondary; Psychomotor Performance; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Substantia Nigra; Tremor; Tyrosine 3-Monooxygenase	1992
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans. Journal of neurology, neurosurgery, and psychiatry, 1990, Volume: 53, Issue:7 Topics: Adolescent; Akinetic Mutism; Biopterins; Child, Preschool; Humans; Infant; Levodopa; Methionine; NADH, NADPH Oxidoreductases; Phenylketonurias; Pyridoxine; S-Adenosylmethionine; Tetrahydrofolates; Tyrosine	1990
Nicotinic acid or N-methyl nicotinamide prolongs elevated brain dopa and dopamine in L-dopa treatment. Biochemical medicine and metabolic biology, 1986, Volume: 36, Issue:2 Topics: Animals; Benserazide; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Levodopa; Liver; Male; Niacinamide; Nicotinic Acids; Rats; Rats, Inbred Strains; S-Adenosylmethionine	1986
The effect of L-DOPA on brain polysomes and protein synthesis: probable mediation by intracellular dopamine. Advances in neurology, 1974, Volume: 5 Topics: 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Carbon Radioisotopes; Decarboxylation; Depression, Chemical; Dihydroxyphenylalanine; Dopamine; Drug Interactions; Enzyme Inhibitors; Hydrazines; Leucine; Levodopa; Lysine; Male; Methyldopa; Nerve Tissue Proteins; Norepinephrine; Polyribosomes; Rats; S-Adenosylmethionine; Time Factors	1974
Decrease of noradrenaline O-methylation in rat brain induced by L-dopa. Reversal effect of S-adenosyl-L-methionine. The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:6 Topics: Animals; Brain; Levodopa; Male; Methoxyhydroxyphenylglycol; Methylation; Norepinephrine; Rats; S-Adenosylmethionine	1980
Tropolone antagonism of the L-dopa-induced elevation of S-adenosylhomocysteine: S-adenosylmethionine ratio but not depletion of adrenaline in rat hypothalamus. The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:6 Topics: Animals; Catechol O-Methyltransferase Inhibitors; Epinephrine; Homocysteine; Hypothalamus; Levodopa; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tropolone	1984
Effect of L-dihydroxyphenylalanine (L-dopa) and methionine on tissue S-adenosylmethionine concentrations in cobalamin-inactivated fruit bats. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1984, Volume: 54, Issue:4 Topics: Animals; Brain; Chiroptera; Levodopa; Liver; Methionine; Nervous System; Nitrous Oxide; S-Adenosylmethionine; Vitamin B 12 Deficiency	1984
High-performance liquid chromatographic analysis of S-adenosylmethionine and its metabolites in rat tissues: interrelationship with changes in biogenic catechol levels following treatment with L-dopa. Journal of chromatography, 1984, May-04, Volume: 290 Topics: Adrenal Glands; Animals; Brain Chemistry; Catechols; Chromatography, High Pressure Liquid; Chromatography, Liquid; Levodopa; Male; Myocardium; Pancreas; Polyamines; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine	1984
Effects of L-dopa on epinephrine concentration in rat brain: possible role of inhibition of norepinephrine N-methyltransferase by S-adenosylhomocysteine. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 223, Issue:1 Topics: Animals; Epinephrine; Hypothalamus; Levodopa; Male; Monoamine Oxidase Inhibitors; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine	1982
Influence of exogenous L-3,4,-dihydroxyphenylalanine (L-dopa) on the methionine and s-adenosylmethionine concentrations in the brain and other tissues [proceedings]. Biochemical Society transactions, 1980, Volume: 8, Issue:1 Topics: Aging; Animals; Brain; Iproniazid; Kidney; Levodopa; Liver; Methionine; Organ Specificity; Rats; S-Adenosylmethionine	1980
Lack of an effect of Madopar on the disposition of tolcapone and its 3-O-methylated metabolite in rats. The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:6 Topics: Animals; Benserazide; Benzophenones; Biotransformation; Catechol O-Methyltransferase Inhibitors; Drug Combinations; Enzyme Inhibitors; Half-Life; Injections, Intravenous; Levodopa; Male; Methylation; Nitrophenols; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Tissue Distribution; Tolcapone	1995
Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry, 1995, Apr-04, Volume: 34, Issue:13 Topics: Animals; Base Sequence; Catechol O-Methyltransferase; Cell Membrane; Dopamine; Enzyme Stability; Hot Temperature; Humans; Hydroxybenzoates; Kinetics; Levodopa; Magnesium; Methylation; Models, Molecular; Molecular Sequence Data; Norepinephrine; Rats; Recombinant Proteins; S-Adenosylmethionine	1995
Potent COMT inhibition by Ro 40-7592 in the periphery and in the brain. Preclinical and clinical findings. Advances in neurology, 1993, Volume: 60 Topics: Animals; Benserazide; Benzophenones; Brain; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dose-Response Relationship, Drug; Erythrocytes; Homovanillic Acid; Humans; Levodopa; Male; Nitrophenols; Peripheral Nerves; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Tolcapone	1993
The effects of L-dopa on the activity of methionine adenosyltransferase: relevance to L-dopa therapy and tolerance. Neurochemical research, 1993, Volume: 18, Issue:3 Topics: Adenosine Triphosphate; Animals; Brain; Chromatography, High Pressure Liquid; Drug Interactions; Levodopa; Male; Methionine; Methionine Adenosyltransferase; Mice; Parkinson Disease; S-Adenosylmethionine	1993
S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson's disease-like symptoms. Behavioral and neural biology, 1993, Volume: 59, Issue:3 Topics: Animals; Behavior, Animal; Catecholamines; Immobilization; Levodopa; Male; Movement Disorders; Parkinson Disease; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Tremor	1993
Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism. Molecular and chemical neuropathology, 1995, Volume: 26, Issue:3 Topics: Animals; Antiparkinson Agents; Caudate Nucleus; Dopamine; Dose-Response Relationship, Drug; Hypokinesia; Injections, Intraventricular; Levodopa; Male; Methylation; Motor Activity; Neostriatum; Parkinson Disease; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tremor	1995
Effect of L-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats. Clinical neuropharmacology, 1997, Volume: 20, Issue:1 Topics: Animals; Benzophenones; Brain; Catechol O-Methyltransferase Inhibitors; Cerebellum; Cerebral Cortex; Corpus Striatum; Enzyme Inhibitors; Hippocampus; Homocysteine; Kidney; Levodopa; Liver; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen	1997
Levels of L-methionine S-adenosyltransferase activity in erythrocytes and concentrations of S-adenosylmethionine and S-adenosylhomocysteine in whole blood of patients with Parkinson's disease. Experimental neurology, 1997, Volume: 145, Issue:2 Pt 1 Topics: Antiparkinson Agents; Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Levodopa; Male; Methionine Adenosyltransferase; Middle Aged; Parkinson Disease; S-Adenosylhomocysteine; S-Adenosylmethionine	1997
Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons. Molecular pharmacology, 2000, Volume: 57, Issue:3 Topics: Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Cell Survival; Cells, Cultured; Dopamine; Dopamine Agents; Enzyme Inhibitors; Levodopa; Mesencephalon; Neurons; Rats; S-Adenosylmethionine; Tyrosine	2000
Effects of L-dopa treatment on methylation in mouse brain: implications for the side effects of L-dopa. Life sciences, 2000, Volume: 66, Issue:23 Topics: Animals; Antiparkinson Agents; Brain Chemistry; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Methionine Adenosyltransferase; Methylation; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet	2000
COMT-dependent protection of dopaminergic neurons by methionine, dimethionine and S-adenosylmethionine (SAM) against L-dopa toxicity in vitro. Brain research, 2001, Mar-02, Volume: 893, Issue:1-2 Topics: Animals; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Cell Survival; Cells, Cultured; Dopamine; Enzyme Inhibitors; Levodopa; Methionine; Neurons; Neuroprotective Agents; Rats; S-Adenosylmethionine	2001
Decrease of methionine and S-adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease. Neuroscience letters, 2001, Jul-27, Volume: 308, Issue:1 Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Cardiovascular Diseases; Dopa Decarboxylase; Down-Regulation; Drug Interactions; Enzyme Inhibitors; Female; Homocysteine; Humans; Levodopa; Male; Methionine; Middle Aged; Parkinson Disease; S-Adenosylmethionine; Up-Regulation	2001
L-dopa upregulates the expression and activities of methionine adenosyl transferase and catechol-O-methyltransferase. Experimental neurology, 2001, Volume: 171, Issue:1 Topics: Animals; Blotting, Western; Brain; Catechol O-Methyltransferase; Dopamine; Enzyme Induction; Kidney; Levodopa; Liver; Male; Methionine Adenosyltransferase; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tyrosine; Up-Regulation	2001
Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicity. Neurochemistry international, 2003, Volume: 42, Issue:2 Topics: Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Enzyme Inhibitors; Female; Levodopa; Lipid Peroxidation; Mesencephalon; Neuroglia; Neurons; Pregnancy; Rats; Rats, Wistar; S-Adenosylmethionine; Selenomethionine; Stereoisomerism	2003
L-DOPA biotransformation: correlations of dosage, erythrocyte catechol O-methyltransferase and platelet SULT1A3 activities with metabolic pathways in Parkinsonian patients. Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:8 Topics: Adenosine Diphosphate; Aged; Arylsulfotransferase; Biotransformation; Blood Platelets; Carbidopa; Catechol O-Methyltransferase; Dose-Response Relationship, Drug; Drug Combinations; Erythrocytes; Female; Humans; Levodopa; Male; Methylation; Middle Aged; Parkinson Disease; S-Adenosylmethionine; Sulfates	2003
Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status. Neurology, 2004, Feb-24, Volume: 62, Issue:4 Topics: Antiparkinson Agents; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Methylation; Parkinson Disease; S-Adenosylmethionine; Vitamin B Complex	2004
Levodopa elevates homocysteine: is this a problem? Archives of neurology, 2004, Volume: 61, Issue:5 Topics: Antiparkinson Agents; Brain; Homocysteine; Humans; Levodopa; Parkinson Disease; Peripheral Nervous System Diseases; S-Adenosylmethionine	2004
Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. Neurology, 2007, Apr-24, Volume: 68, Issue:17 Topics: Antiparkinson Agents; Carbon; Catechol O-Methyltransferase Inhibitors; Catechols; Folic Acid; Humans; Hyperhomocysteinemia; Levodopa; Nitriles; Parkinson Disease; Randomized Controlled Trials as Topic; S-Adenosylmethionine; Time Factors; Vitamin B 12; Vitamin B 6	2007
Impaired transmethylation potential in Parkinson's disease patients treated with L-Dopa. Neuroscience letters, 2010, Jan-14, Volume: 468, Issue:3 Topics: Aged; Antiparkinson Agents; Cross-Sectional Studies; Erythrocytes; Female; Genotype; Homocysteine; Humans; Levodopa; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Parkinson Disease; Polymorphism, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine	2010
Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors. Acta crystallographica. Section D, Biological crystallography, 2012, Volume: 68, Issue:Pt 3 Topics: Binding Sites; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Crystallography, X-Ray; Deoxyribose; Dopamine; Drug Design; Levodopa; Models, Molecular; Parkinson Disease; Ribose; S-Adenosylmethionine	2012
S-adenosylmethionine administration inhibits levodopa-induced vascular endothelial growth factor-A expression. Aging, 2020, 11-07, Volume: 12, Issue:21 Topics: Antiparkinson Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Human Umbilical Vein Endothelial Cells; Humans; Levodopa; Neovascularization, Physiologic; S-Adenosylmethionine; Vascular Endothelial Growth Factor A	2020