levodopa has been researched along with n-methylaspartate in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 13 (46.43) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Arnold, G; Klockgether, T; Kupsch, A; Oertel, W; Renner, P; Scheid, C; Scheid, R; Wüllner, U | 1 |
| Frey, HH; Voits, M | 1 |
| Klockgether, T; Turski, L | 1 |
| Boyce, S; Crossman, AR; Luquin, MR; Peggs, D; Sambrook, MA | 1 |
| Farel, PB; McClellan, AD | 1 |
| Ossowska, K | 1 |
| Danysz, W; Quack, G; Rogoz, Z; Skuza, G | 1 |
| Archer, T; Fredriksson, A; Gentsch, C | 1 |
| Boldry, RC; Chase, TN; Engber, TM | 1 |
| Breese, GR; Criswell, HE; Johnson, KB; Mueller, RA | 1 |
| Blin, O; Fabre, N; Montastruc, JL; Rascol, O; Senard, JM | 1 |
| Barbeau, H; Bouyer, L; Brustein, E; Chau, C; Giroux, N; Reader, TA; Rossignol, S | 1 |
| Klockgether, T; Löschmann, PA; Spieker, S | 1 |
| Agid, Y; Hirsch, EC; Jimenez, A; Marin, C; Raisman-Vozari, R; Ruberg, M; Tolosa, E; Vila, M | 1 |
| Archer, T; Chase, T; Fredriksson, A; Palomo, T | 1 |
| Emre, M; Hanağasi, HA; Kaptanoglu, G; Sahin, HA | 1 |
| Müller, T | 1 |
| Archer, T; Fredriksson, A | 1 |
| Beani, L; Bianchi, C; Marti, M; Mela, F; Morari, M; Paganini, F; Stocchi, S | 1 |
| Ninan, I; Wang, RY | 1 |
| Jankovic, J; Olanow, CW | 1 |
| Berger, SP; Brudney, EG; Johnson, SW; Meshul, CK; Paquette, MA; Putterman, DB | 1 |
| Allbutt, HN; Coster, MJ; Henderson, JM; Kassiou, M; Truong, L | 1 |
| Di Rocco, A; Howard, J; Varanese, S | 1 |
| Bagetta, V; Bonito-Oliva, A; Calabresi, P; Carta, M; Di Luca, M; Errico, F; Fisone, G; Gardoni, F; Marinucci, S; Napolitano, F; Picconi, B; Romano, R; Usiello, A; Vitucci, D; Zianni, E | 1 |
| Frouni, I; Huot, P | 1 |
| Liu, M; Tuo, J; Xu, Z; Yu, C; Zhang, F; Zhang, J; Zhang, L | 1 |
5 review(s) available for levodopa and n-methylaspartate
| Article | Year |
|---|---|
The role of excitatory amino acids in experimental models of Parkinson's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Catalepsy; Disease Models, Animal; Excitatory Amino Acids; Levodopa; N-Methylaspartate; Oxidopamine; Parkinson Disease; Rats | 1994 |
Non-dopaminergic drug treatment of Parkinson's disease.
Topics: Adenosine; Adrenergic alpha-Antagonists; Body Weight; Cholinergic Antagonists; Homocysteine; Humans; Levodopa; Methionine; N-Methylaspartate; Parkinson Disease; Piperidines; Serotonin Receptor Agonists | 2001 |
Neuroprotective therapy in Parkinson's disease and motor complications: a search for a pathogenesis-targeted, disease-modifying strategy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents; Coenzymes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Humans; Indans; Levodopa; Membrane Proteins; N-Methylaspartate; Neuroprotective Agents; Parkinson Disease; Prostaglandin-Endoperoxide Synthases; Ubiquinone; Vitamin E | 2005 |
Glutamate modulation for the treatment of levodopa induced dyskinesia: a brief review of the drugs tested in the clinic.
Topics: Antiparkinson Agents; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; N-Methylaspartate; Parkinson Disease | 2022 |
Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation.
Topics: Aged; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; Middle Aged; N-Methylaspartate; Neuroinflammatory Diseases; Parkinson Disease; Quality of Life; Receptors, N-Methyl-D-Aspartate | 2023 |
1 trial(s) available for levodopa and n-methylaspartate
| Article | Year |
|---|---|
The NMDA antagonist budipine can alleviate levodopa-induced motor fluctuations.
Topics: Adult; Aged; Antiparkinson Agents; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; N-Methylaspartate; Parkinson Disease; Pilot Projects; Piperidines; Severity of Illness Index | 1999 |
22 other study(ies) available for levodopa and n-methylaspartate
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
The competitive NMDA antagonist CGP40.116 enhances L-dopa response in MPTP-treated marmosets.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Callithrix; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Motor Activity; N-Methylaspartate | 1992 |
Effect of psychotropic agents on a model of absence epilepsy in rats.
Topics: Animals; Antidepressive Agents; Dextroamphetamine; Electroencephalography; Epilepsy; Female; Levodopa; Male; Memantine; Morphine; N-Methylaspartate; Parasympatholytics; Psychotropic Drugs; Rats; Rats, Inbred Strains | 1991 |
NMDA antagonists potentiate antiparkinsonian actions of L-dopa in monoamine-depleted rats.
Topics: Animals; Dizocilpine Maleate; Drug Synergism; Electromyography; Levodopa; Male; Methyltyrosines; Motor Activity; Muscle Rigidity; N-Methylaspartate; Parkinson Disease; Piperazines; Rats; Rats, Inbred Strains; Reserpine | 1990 |
Effect of the NMDA antagonist MK-801 on MPTP-induced parkinsonism in the monkey.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Injections, Intramuscular; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; N-Methylaspartate; Parkinson Disease, Secondary | 1989 |
Pharmacological activation of locomotor patterns in larval and adult frog spinal cords.
Topics: 2-Aminoadipic Acid; 5-Hydroxytryptophan; Animals; Apomorphine; Aspartic Acid; Benserazide; Clonidine; In Vitro Techniques; Larva; Levodopa; Locomotion; N-Methylaspartate; Nialamide; Rana catesbeiana; Rana pipiens; Spinal Cord | 1985 |
Memantine, amantadine, and L-deprenyl potentiate the action of L-dopa in monoamine-depleted rats.
Topics: Amantadine; Animals; Bromocriptine; Dopamine; Drug Synergism; Levodopa; Male; Memantine; Motor Activity; N-Methylaspartate; Parkinson Disease; Rats; Rats, Wistar; Selegiline | 1994 |
Synergistic interactions between NMDA-antagonists and L-dopa on activity in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1994 |
Influence of previous exposure to levodopa on the interaction between dizocilpine and dopamine D1 and D2 agonists in rats with 6-hydroxydopamine-induced lesions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Brain Diseases; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Levodopa; Male; Motor Activity; N-Methylaspartate; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1993 |
Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats.
Topics: alpha-Methyltyrosine; Animals; Animals, Newborn; Behavior, Animal; Brain; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Gene Expression; Genes, fos; Levodopa; Male; Methyltyrosines; N-Methylaspartate; Pipecolic Acids; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Serotonin; Tyrosine 3-Monooxygenase | 1993 |
N-methyl-D-aspartate (NMDA) antagonist and Parkinson's disease: a pilot study with dextromethorphan.
Topics: Aged; Dextromethorphan; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; N-Methylaspartate; Neurologic Examination; Parkinson Disease; Receptors, N-Methyl-D-Aspartate | 1994 |
Pharmacological activation and modulation of the central pattern generator for locomotion in the cat.
Topics: 5-Hydroxytryptophan; Animals; Cats; Clonidine; Denervation; Dopamine Agents; Electromyography; Excitatory Amino Acid Agonists; Glutamic Acid; Levodopa; Locomotion; Methoxamine; Motor Neurons; Muscle, Skeletal; N-Methylaspartate; Norepinephrine; Periodicity; Reflex; Serotonin; Spinal Cord; Sympatholytics; Sympathomimetics; Synaptic Transmission | 1998 |
Systemic administration of NMDA and AMPA receptor antagonists reverses the neurochemical changes induced by nigrostriatal denervation in basal ganglia.
Topics: Animals; Basal Ganglia; Corpus Striatum; Denervation; Dizocilpine Maleate; Dopamine; Electron Transport Complex IV; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Isoquinolines; Levodopa; Male; N-Methylaspartate; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Messenger; Substantia Nigra; Tetrazoles | 1999 |
Tolerance to a suprathreshold dose of L-Dopa in MPTP mice: effects of glutamate antagonists.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Antiparkinson Agents; Differential Threshold; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Sexual Behavior, Animal | 1999 |
The use of NMDA antagonist memantine in drug-resistant dyskinesias resulting from L-dopa.
Topics: Adult; Antiparkinson Agents; Dopamine Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Humans; Levodopa; Male; Memantine; N-Methylaspartate; Parkinsonian Disorders; Treatment Outcome | 2000 |
Functional alteration by NMDA antagonist: effects of L-Dopa, neuroleptics drug and postnatal administration.
Topics: Age Factors; Animals; Animals, Newborn; Antiparkinson Agents; Antipsychotic Agents; Excitatory Amino Acid Antagonists; Female; Humans; Levodopa; Male; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Oxidopamine; Parkinsonian Disorders; Pregnancy; Rats; Rats, Sprague-Dawley; Sympatholytics | 2002 |
Plasticity of glutamatergic control of striatal acetylcholine release in experimental parkinsonism: opposite changes at group-II metabotropic and NMDA receptors.
Topics: Acetylcholine; Animals; Antiparkinson Agents; Benserazide; Corpus Striatum; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Male; N-Methylaspartate; Neuronal Plasticity; Parkinsonian Disorders; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 2003 |
Modulation of the ability of clozapine to facilitate NMDA- and electrically evoked responses in pyramidal cells of the rat medial prefrontal cortex by dopamine: pharmacological evidence.
Topics: 5-Hydroxytryptophan; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Benzazepines; Clozapine; Dopamine; Dopamine Agents; Dopamine Antagonists; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Levodopa; Male; N-Methylaspartate; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reserpine; Synaptic Transmission; Tyrosine 3-Monooxygenase | 2003 |
Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias.
Topics: Adrenergic Agents; Amphetamine; Animals; Anti-Anxiety Agents; Behavior, Animal; Dextromethorphan; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Levodopa; Ligands; Male; N-Methylaspartate; Neurotoxicity Syndromes; Oxidopamine; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+parafascicular lesions.
Topics: Administration, Oral; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Dopamine; Excitatory Amino Acid Antagonists; Female; Immunohistochemistry; Intralaminar Thalamic Nuclei; Levodopa; Medial Forebrain Bundle; N-Methylaspartate; Neurons; Oxidopamine; Parkinson Disease, Secondary; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rotation; Tyrosine 3-Monooxygenase | 2009 |
NMDA antagonist memantine improves levodopa-induced dyskinesias and "on-off" phenomena in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Dopamine Agents; Dyskinesia, Drug-Induced; Female; Humans; Incidence; Levodopa; Male; Memantine; N-Methylaspartate; Parkinson Disease | 2010 |
Higher free D-aspartate and N-methyl-D-aspartate levels prevent striatal depotentiation and anticipate L-DOPA-induced dyskinesia.
Topics: Action Potentials; Animals; Antiparkinson Agents; Corpus Striatum; D-Aspartate Oxidase; D-Aspartic Acid; Dyskinesia, Drug-Induced; Extracellular Signal-Regulated MAP Kinases; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neuronal Plasticity; Oxidopamine; Parkinsonian Disorders; Phosphorylation; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sympatholytics; Synapses | 2011 |