Page last updated: 2024-08-17

levodopa and methyldopa

levodopa has been researched along with methyldopa in 130 studies

Research

Studies (130)

Timeframe	Studies, this research(%)	All Research%
pre-1990	76 (58.46)	18.7374
1990's	19 (14.62)	18.2507
2000's	18 (13.85)	29.6817
2010's	17 (13.08)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ax, F; Bonham, NM; Hallberg, A; Karlén, A; Lennernäs, H; Winiwarter, S	1
Amidon, GL; Han, HK; Hsu, CP; Oh, DM; Rhie, JK; Saito, G; Stewart, BH	1
Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Davidson, L; Hornykiewicz, O; Lloyd, KG	1
Harrewijn, P	1
Warchoł, JB; Zabel, M	1
Bidard, JN; Cronenberger, L; Fonlupt, P; Pacheco, H	1
Sternon, J	1
Culvenor, AJ; Jarrott, B	1
Luchins, D	2
Sherman, GP; Walton, CA	1
Atkinson, AR; Norris, KA; Smith, WG	1
Dabagov, NS; Skoldinov, AP; Uspenskiĭ, AE	1
Doyle, AE; Jarrott, B; Louis, WJ; McNeil, JJ; Vajda, FJ	1
Comi, R; Fahn, S; Prasad, AL; Snider, SR	1
Wick, MM	1
Zabel, M	2
Sjönell, G	1
Clay, KL; Murphy, RC	1
Duvoisin, RC; Mytilineou, C	1
Feuerstein, C; Gavend, M; Pellat, J; Perret, J; Serre, F; Tanche, M	2
Das Gupta, D; Ghanekar, AG	1
Henocque, G; Koffi, A; Macart, M	1
Ernst, AM	1
Marsden, CD; Mindham, RH; Parkes, JD	1
Woods, RI	1
Thut, PD	1
Debono, AG; Jenner, P; Parkes, JD; Walters, J	1
Deruaz, D; Gjessing, L; Greffe, J; Guilluy, R; Mathieu, P	1
Feigenson, JS; McDowell, FH; Sweet, RD	1
Goodale, DB; Moore, KE	1
Korobov, NV; Uspenskiĭ, AE	1
Maître, L; Waldmeier, PC	1
Katzman, R; Wade, LA	1
Horie, R; Yamori, Y	1
McDowell, FH; Sweet, RD	2
Chibata, I; Yamada, S; Yamamoto, M	1
Cheng, LK; Fung, HL	1
Balestreri, R; Bertolini, S; Costa, S; Elicio, N	1
Anisimov, VN	1
Hodge, CJ; King, RB	1
Meites, J; Riegle, GD	1
Nevsímal, O; Roth, B; Vymazal, J	1
Calne, DB; Fermaglich, J	1
Collin, C; Eckernäs, SA; Grahnén, A; Ling-Andersson, A; Nilsson, M; Tiger, G	1
Männistö, PT; Tuomainen, P; Tuominen, RK	1
De Klippel, N; Deleu, D; Ebinger, G; Herregodts, P; Michotte, Y; Sarre, S	1
Bałuk, P; Gabella, G	1
Greene, RJ; Hall, AD; Hider, RC	1
Barbier, C; Huguet, C; Robinet, D; Said, R; Sartre, J	1
Medenica, M; Nikolić, K	1
Davoudi, H; Durso, R; Feldman, RG; Szabo, G	1
Issopoulos, PB	1
Bennett, JP; Landow, E; Turk, M	1
Fujimoto, H; Kawai, H; Masuda, T; Saito, S	1
Bazan, E; de Yebenes, JG; Mena, MA; Muradas, V; Reiriz, J	1
Nutt, JG	1
Nagatsu, T; Naoi, M	1
Jenner, P; Marion, MH; Marsden, CD; Quinn, NP; Stocchi, F	1
Hardie, RJ; Lees, AJ; Stern, GM	1
Evans, WS; Ho, KY; Thorner, MO	1
Munro, HN; Roel, LE; Weiss, BF; Wurtman, RJ	1
Colombo, JP; Küffer, H; Peheim, E; Richterich, R	1
Antonaccio, MJ; Burrell, R; Robson, RD	1
Muenter, MD; Sharpless, NS; Tyce, GM	1
Andén, NE; Engel, J	1
Lindén, IB	1
Daniele, E; Zamboni, P	1
Petz, LD	1
Da Prada, M; Haefely, WE; Keller, HH; Kettler, R; Pieri, L	1
Fahn, S; Reches, A	1
Gelber, LR; Neumeyer, JL	1
Kemi, M; Kondo, M; Maki, E; Tanabe, K	1
Adam, WR; Campbell, DJ; Funder, JW; Mendelsohn, FA	1
Ardaillou, R; Hagege, J; Loreau, N; Wahbe, F	1
Fahn, S; Jiang, D; Reches, A	1
Henning, M; Johansson, P	1
Nuzhnyĭ, VP; Uspenskiĭ, AE; Zabirova, IG	1
Reilly, DK; Rivera-Calimlim, L; Van Dyke, D	1
Jung, MJ; Palfreyman, MG; Ribéreau-Gayon, G; Wagner, J; Zraïka, M	1
Deleu, D; Ebinger, G; Michotte, Y; Sarre, S; Van Belle, K	1
Carey, RJ; Huston, JP; Pinheiro-Carrera, M; Tomaz, C	1
Bräutigam, K; Morgenstern, R; Sohr, R	1
García Cánovas, F; García Moreno, M; Sánchez Gracia, A; Tudela, J; Varón, R	1
Rausing, A; Rosén, U	1
Clarke, JB; Gandolfi, AJ; Hastings, K; Hubbard, AK; Lohr, CL	1
Deleu, D; Ebinger, G; Michotte, Y; Sarre, S	1
Andre, MH; Bruguerolle, B; Grignon, S	1
Balogh-Nemes, K; Horvai, G; Klebovich, I; Tolokán, A	1
Dolezalová, M; Tkaczyková, M	1
Ameyaw, MM; McLeod, HL; Ofori-Adjei, D; Syvänen, AC; Ulmanen, I	1
Szakács, T; Vereczkey, L; Veres, Z	1
Forsberg, M; Gogos, JA; Huotari, M; Hyttinen, J; Karayiorgou, M; Koponen, O; Männistö, PT; Raasmaja, A	1
Fekete, MI; Fülöp, F; Homicskó, KG; Kertész, I; Nagy, GM; Radnai, B; Tóth, BE; Tóth, G	1
Arstrand, K; Dizdar, N; Kågedal, B	1
Crevoisier, C; Metzger, B; Monreal, A; Nilsen, T	1
Parada, A; Soares-da-Silva, P; Vieira-Coelho, MA	1
SOULAIRAC, A; SOULAIRAC, ML	1
Bendsoe, N; Falck, B; Ronquist, G	1
Andrews, AM; Holmes, A; Huang, SJ; Kim, DK; Lesch, KP; Martin, BJ; Murphy, DL; Tolliver, TJ; Wichems, C	1
Aisen, P; Casadevall, A; Dadachova, E; Eisenman, HC; Garcia-Rivera, J; Moadel, T; Nosanchuk, JD; Zaragoza, O	1
Dean, RT; Hume, PM; Morris, JG; Rodgers, KJ	1
Chamsaz, M; Fadaee, J; Safavi, A	1
Fu, HY; Li, SF; Li, YN; Nie, JF; Wu, HL; Yu, RQ; Yu, YJ	1
Fisher, R; Jackson, MJ; Jenner, P; Rose, S; Tayarani-Binazir, KA; Zoubiane, G	1
Antonini, A; Bareggi, SR; Bondiolotti, G; Natuzzi, F	1
Barba, E; Bugamelli, F; Marcheselli, C; Raggi, MA	1
Bengel, G; Ebersbach, G; Ehret, R; Jugel, C; Klostermann, F; Muhlack, S; Müller, T	1
Bonfim, RR; Byrro, RM; Cardoso, FF; César, Ida C; da Silva, EP; Gomes, SA; Mundim, IM; Pianetti, GA; Teixeira, Lde S	1
Bonfim, RR; Byrro, RM; César, IC; Gomes, SA; Mundim, IM; Pianetti, GA; Santana E Silva Cardoso, FF; Souza Teixeira, L	1
Asanuma, M; Kikkawa, Y; Kimoto, N; Miyazaki, I; Miyoshi, K; Murakami, S; Takeshima, M	1
Barbe, MT; Christensen, MS; Florin, E; Herz, DM; Reck, C; Siebner, HR; Timmermann, L; Tittgemeyer, M; Tscheuschler, MK	1
Muhlack, S; Müller, T	1

Reviews

8 review(s) available for levodopa and methyldopa

Article	Year
Biogenic amines and affective disorders. A critical analysis. International pharmacopsychiatry, 1976, Volume: 11, Issue:3 Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar Disorder; Brain Chemistry; Clinical Trials as Topic; Depression; Electroconvulsive Therapy; Fenclonine; Fusaric Acid; Humans; Levodopa; Lithium; Methyldopa; Methyltyrosines; Methysergide; Monoamine Oxidase Inhibitors; Phenylketonurias; Reserpine; Tryptophan	1976
Adrenergic transmission and drug interaction. Journal of the American Pharmaceutical Association, 1975, Volume: 15, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Antidepressive Agents; Catechol O-Methyltransferase; Drug Interactions; Guanethidine; Humans; Levodopa; Methyldopa; Monoamine Oxidase Inhibitors; Neurons; Norepinephrine; Receptors, Adrenergic; Reserpine; Sympathetic Nervous System; Synaptic Transmission	1975
Compulsive gnawing. Pharmacology & therapeutics. Part B: General & systematic pharmacology, 1976, Volume: 2, Issue:1 Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Behavior, Animal; Benserazide; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Iproniazid; Levodopa; Male; Methyldopa; Methyltyrosines; Rats; Serotonin; Structure-Activity Relationship; Time Factors	1976
The case for and concerns about continuous dopamine stimulation in Parkinson's disease. Journal of neural transmission. Supplementum, 1988, Volume: 27 Topics: Administration, Oral; Animals; Delayed-Action Preparations; Dopamine; Drug Tolerance; Humans; Infusion Pumps; Levodopa; Methyldopa; Parkinson Disease; Stimulation, Chemical	1988
Disorders of prolactin and growth hormone secretion. Clinics in endocrinology and metabolism, 1985, Volume: 14, Issue:1 Topics: Acromegaly; Arginine; Clonidine; Dwarfism; Female; Glucose Tolerance Test; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Hypothalamo-Hypophyseal System; Hypothyroidism; Insulin-Like Growth Factor I; Kidney Failure, Chronic; Lactation; Levodopa; Male; Methyldopa; Physical Exertion; Pituitary Neoplasms; Pregnancy; Prolactin; Propranolol; Reserpine; Sleep; Somatomedins; Thyrotropin-Releasing Hormone	1985
Drug-induced immune haemolytic anaemia. Clinics in haematology, 1980, Volume: 9, Issue:3 Topics: Adsorption; Anemia, Hemolytic, Autoimmune; Autoantibodies; Autoantigens; Blood Transfusion; Cephalosporins; Complement Activation; Coombs Test; Erythrocyte Aging; gamma-Globulins; Haptens; Humans; Immunity, Cellular; Levodopa; Mefenamic Acid; Methyldopa; Penicillins	1980
The pharmacology of Parkinson's disease: basic aspects and recent advances. Experientia, 1984, Nov-15, Volume: 40, Issue:11 Topics: Animals; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Bromocriptine; Carbidopa; Corpus Striatum; Dopamine; Ergolines; Humans; Kidney; Kinetics; Levodopa; Lisuride; Liver; Methyldopa; Norepinephrine; Parkinson Disease; Pergolide; Receptors, Dopamine; Selegiline; Serotonin; Stereotyped Behavior; Substantia Nigra; Tyramine	1984
Is aldosterone secretion under dopaminergic control? Circulation research, 1981, Volume: 49, Issue:6 Topics: Aldosterone; Bromocriptine; Chlorpromazine; Dopamine; Dopamine Antagonists; Edema; Humans; Levodopa; Methyldopa; Metoclopramide; Parkinson Disease; Sulpiride	1981

Trials

6 trial(s) available for levodopa and methyldopa

Article	Year
Biogenic amines and affective disorders. A critical analysis. International pharmacopsychiatry, 1976, Volume: 11, Issue:3 Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar Disorder; Brain Chemistry; Clinical Trials as Topic; Depression; Electroconvulsive Therapy; Fenclonine; Fusaric Acid; Humans; Levodopa; Lithium; Methyldopa; Methyltyrosines; Methysergide; Monoamine Oxidase Inhibitors; Phenylketonurias; Reserpine; Tryptophan	1976
The combined use of L-alpha-methyldopa hydrazine and methyldopa in the treatment of hypertension. Clinical and experimental pharmacology & physiology. Supplement, 1978, Volume: 4 Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrazines; Hypertension; Levodopa; Male; Methyldopa; Middle Aged; Placebos; Time Factors	1978
Psychiatric symptoms during l-dopa therapy for Parkinson's disease and their relationship to physical disability. Psychological medicine, 1976, Volume: 6, Issue:1 Topics: Aged; Amantadine; Carbidopa; Clinical Trials as Topic; Depression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Interview, Psychological; Levodopa; Male; Mental Status Schedule; Methyldopa; Middle Aged; Parkinson Disease; Placebos; Recurrence; Trihexyphenidyl	1976
Comparative multiple-dose pharmacokinetics of controlled-release levodopa products. European neurology, 1992, Volume: 32, Issue:6 Topics: Adult; Antiparkinson Agents; Carbidopa; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Humans; Levodopa; Male; Metabolic Clearance Rate; Methyldopa; Neurologic Examination; Parkinson Disease	1992
Comparative single- and multiple-dose pharmacokinetics of levodopa and 3-O-methyldopa following a new dual-release and a conventional slow-release formulation of levodopa and benserazide in healthy volunteers. European neurology, 2003, Volume: 49, Issue:1 Topics: Adult; Antiparkinson Agents; Benserazide; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Dopamine Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Humans; Levodopa; Male; Methyldopa; Reference Values	2003
Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel. Journal of neural transmission (Vienna, Austria : 1996), 2011, Volume: 118, Issue:9 Topics: Aged; Antiparkinson Agents; Carbidopa; Drug Combinations; Duodenum; Female; Gels; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	2011

Other Studies

117 other study(ies) available for levodopa and methyldopa

Article	Year
Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. Journal of medicinal chemistry, 1998, Dec-03, Volume: 41, Issue:25 Topics: Humans; Intestinal Absorption; Jejunum; Models, Biological; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship	1998
CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. Journal of pharmaceutical sciences, 1999, Volume: 88, Issue:3 Topics: Animals; Biological Transport; Caco-2 Cells; Carrier Proteins; CHO Cells; Cricetinae; Dipeptides; Humans; Kinetics; Peptide Transporter 1; Reproducibility of Results; Symporters; Transfection	1999
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. The Journal of biological chemistry, 2001, May-18, Volume: 276, Issue:20 Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis	2001
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
The neurochemistry of Parkinson's disease: effect of L-dopa therapy. The Journal of pharmacology and experimental therapeutics, 1975, Volume: 195, Issue:3 Topics: Aged; Brain; Catechol O-Methyltransferase; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Female; Homovanillic Acid; Humans; Levodopa; Male; Methyldopa; Middle Aged; Monoamine Oxidase; Parkinson Disease; Tyrosine 3-Monooxygenase	1975
Role of monoamine metabolism in wing dimorphism of the aphid Myzus persicae. Comparative biochemistry and physiology. C: Comparative pharmacology, 1976, Volume: 55, Issue:2 Topics: Animals; Aphids; Autonomic Agents; Dopamine; Fenclonine; Isoproterenol; Levodopa; Methyldopa; Norepinephrine; Physostigmine; Reserpine; Tryptamines; Wings, Animal	1976
The effect of l-dopa and alpha-methyl-dopa on C cell secretion in the thyroid gland. Acta medica Polona, 1977, Volume: 18, Issue:4 Topics: Animals; APUD Cells; Guinea Pigs; Levodopa; Methyldopa; Thyroid Gland	1977
[Effect of S-adenosyl-L-methionine on the cerebral and peripheral metabolism of L-dopa]. Archives internationales de physiologie et de biochimie, 1978, Volume: 86, Issue:4 Topics: Animals; Biological Transport; Brain; Catecholamines; Dopamine; Levodopa; Male; Methyldopa; Norepinephrine; Normetanephrine; Rats; S-Adenosylmethionine; Tissue Distribution	1978
[The practitioner and drug-induced, predominantly orthostatic hypotension]. Acta clinica Belgica, 1978, Volume: 33, Issue:6 Topics: Adrenergic Agents; Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Antipsychotic Agents; Barbiturates; Butyrophenones; Clonidine; Debrisoquin; Diazoxide; Diuretics; Ganglionic Blockers; Humans; Hydralazine; Hypotension, Orthostatic; Levodopa; Meprobamate; Methyldopa; Mineralocorticoids; Monoamine Oxidase Inhibitors; Phenothiazines; Prazosin; Psychotropic Drugs; Reserpine; Vasodilator Agents	1978
Reduction in the level of immunotitratable dopamine beta-hydroxylase after chronic administration of L-dopa or alpha-methyldopa. Neuroscience, 1979, Volume: 4, Issue:9 Topics: Adrenal Glands; Amino Acids; Animals; Carboxy-Lyases; Dopamine beta-Hydroxylase; Heart; Immunoassay; Immunodiffusion; Kinetics; L-Lactate Dehydrogenase; Levodopa; Male; Methyldopa; Myocardium; Rats	1979
Colorimetric enzymatic determination of serum total carbon dioxide, as applied to the Vickers Multichannel 300 discrete analyzer. Clinical chemistry, 1975, Volume: 21, Issue:8 Topics: Acetoacetates; Aminosalicylic Acids; Animals; Ascorbic Acid; Autoanalysis; Bilirubin; Carbon Dioxide; Carboxy-Lyases; Edible Grain; Humans; Hydrogen-Ion Concentration; Isoniazid; Levodopa; Malate Dehydrogenase; Methyldopa; Myocardium; Oxaloacetates; Phosphoenolpyruvate; Pyruvates; Sulfathiazoles; Swine	1975
[Pharmacology of several aromatic amino acid decarboxylase inhibitors]. Biulleten' eksperimental'noi biologii i meditsiny, 1978, Volume: 86, Issue:10 Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Drug Interactions; Indoles; Kidney; Lactates; Levodopa; Methyldopa; Phenylacetates; Rabbits	1978
Effect of a catechol-O-methyl transferase inhibitor, U-0521, with levodopa administration. Biochemical pharmacology, 1979, Apr-01, Volume: 28, Issue:7 Topics: Animals; Behavior, Animal; Brain; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Homovanillic Acid; Levodopa; Male; Methyldopa; Propiophenones; Rats; Time Factors	1979
Levodopa and dopamine analogs: melanin precursors as antitumor agents in experimental human and murine leukemia. Cancer treatment reports, 1979, Volume: 63, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cells, Cultured; Dopamine; Humans; Leukemia L1210; Leukemia, Experimental; Levodopa; Male; Methyldopa; Mice; Nervous System; Structure-Activity Relationship	1979
Ultrastructure of thyroid C cells following long-term administration of 1-DOPA or alpha-methyl-DOPA. Acta medica Polona, 1979, Volume: 20, Issue:1 Topics: Animals; Levodopa; Male; Methyldopa; Rats; Thyroid Gland; Time Factors	1979
[Alphamethyldopa and levodopa interaction]. Lakartidningen, 1979, Nov-07, Volume: 76, Issue:45 Topics: Aged; Drug Interactions; Female; Humans; Levodopa; Methyldopa; Parkinson Disease	1979
New procedure for isolation of amino acids based on selective hydrolysis of trimethylsilyl derivatives. Journal of chromatography, 1979, Dec-01, Volume: 164, Issue:4 Topics: Amino Acids; Gas Chromatography-Mass Spectrometry; Humans; Levodopa; Methyldopa; Trimethylsilyl Compounds; Tyrosine	1979
Where is L-DOPA decarboxylated in the striatum after 6-hydroxydopamine nigrotomy? Brain research, 1978, Aug-25, Volume: 152, Issue:2 Topics: Animals; Benserazide; Blood-Brain Barrier; Capillaries; Corpus Striatum; Decarboxylation; Dopamine; Endothelium; Female; Humans; Hydroxydopamines; Levodopa; Methyldopa; Premedication; Rats; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra	1978
Plasma O-methyldopa in levodopa-induced dyskinesias. A bioclinical investigation. Acta neurologica Scandinavica, 1977, Volume: 56, Issue:6 Topics: Aged; Benserazide; Carbidopa; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	1977
Applications of paired ion high-pressure liquid chromatography to catecholamines and phenylephrine. Journal of pharmaceutical sciences, 1978, Volume: 67, Issue:9 Topics: Capsules; Catecholamines; Chromatography, High Pressure Liquid; Levodopa; Methods; Methyldopa; Phenylephrine; Solutions; Tablets	1978
[Adaptation to the Centrifichem of the estimation of blood sugar according to Trinder's method. Kinetic study of the main drug interferences (author's transl)]. Annales de biologie clinique, 1978, Volume: 36, Issue:2 Topics: Ascorbic Acid; Blood Glucose; Centrifugation; Gentisates; Kinetics; Levodopa; Methyldopa	1978
Does O-methyl-dopa play a role in levodopa-induced dyskinesias? Acta neurologica Scandinavica, 1977, Volume: 56, Issue:1 Topics: Adult; Aged; Benserazide; Carbidopa; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	1977
Changes in sizes of the adrenaline-containing vesicles and their cores in frog cardiac sympathetic nerves after pharmacological treatments. Journal of neurocytology, 1977, Volume: 6, Issue:4 Topics: Animals; Anura; Autonomic Fibers, Postganglionic; Dopamine; Dose-Response Relationship, Drug; Epinephrine; Heart; Histocytochemistry; Hydroxydopamines; Levodopa; Male; Methyldopa; Methyltyrosines; Norepinephrine; Sympathetic Nervous System	1977
Effect of L-DOPA analogues in Sidman avoidance performance in mice. Life sciences, 1977, Aug-01, Volume: 21, Issue:3 Topics: Animals; Avoidance Learning; Benserazide; Brain; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Methyldopa; Mice; Motor Activity; Norepinephrine; Serotonin	1977
Amphetamines, growth hormone and narcolepsy. British journal of clinical pharmacology, 1977, Volume: 4, Issue:3 Topics: Adult; Aged; Amphetamine; Arousal; Clomipramine; Dextroamphetamine; Drug Interactions; Drug Tolerance; Female; Growth Hormone; Hemodynamics; Humans; Levodopa; Male; Methyldopa; Middle Aged; Narcolepsy; Time Factors	1977
N-Acetyl, 4-O-methyldopa, a major metabolite of L-4-O-methyldopa in man and rat. Biochemical pharmacology, 1976, Mar-01, Volume: 25, Issue:5 Topics: Acetylation; Adult; Animals; Dopamine; Female; Homovanillic Acid; Humans; Isomerism; Lactates; Levodopa; Male; Methyldopa; Pyruvates; Rats; Species Specificity	1976
Piribedil: its synergistic effect in multidrug regimens for parkinsonism. Neurology, 1976, Volume: 26, Issue:5 Topics: Aged; Amantadine; Drug Synergism; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Movement Disorders; Parasympatholytics; Parkinson Disease; Piperazines; Piribedil	1976
A comparison of the effects of decarboxylase inhibitors on L-dopa-induced circling behavior and the conversion of dopa to dopamine in the brain. Life sciences, 1976, Sep-01, Volume: 19, Issue:5 Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Benserazide; Brain; Brocresine; Carbidopa; Dopamine; Hydrazines; Levodopa; Male; Methyldopa; Rats; Time Factors	1976
[Facilitation of the effects of L-DOPA by alpha-methyldopa]. Biulleten' eksperimental'noi biologii i meditsiny, 1976, Volume: 81, Issue:3 Topics: Animals; Blood Pressure; Catalepsy; Cats; Dopamine; Drug Interactions; Drug Therapy, Combination; Haloperidol; Humans; Levodopa; Male; Methyldopa; Mice; Nictitating Membrane; Reserpine	1976
Comparison of short and long-lasting effects of pargyline on cerebral dopamine metabolism. Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 294, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cisterna Magna; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Injections; Injections, Intravenous; Levodopa; Methyldopa; Monoamine Oxidase; Pargyline; Rats; Time Factors; Tyrosine	1976
3-O-methyldopa uptake and inhibition of L-dopa at the blood-brain barrier. Life sciences, 1975, Jul-01, Volume: 17, Issue:1 Topics: Animals; Biological Availability; Biological Transport, Active; Blood-Brain Barrier; Brain; Cerebral Cortex; Corpus Striatum; Diffusion; Hypothalamus; Kinetics; Levodopa; Male; Mesencephalon; Methyldopa; Parkinson Disease; Rats	1975
Experimental studies on the pathogenesis and prophylaxis of stroke in stroke-prone spontaneously hypertensive rats (SHR). (2) Prophylactic effect of moderate control of blood pressure on stroke. Japanese circulation journal, 1975, Volume: 39, Issue:5 Topics: Animals; Carbidopa; Carboxy-Lyases; Cerebrovascular Disorders; Heart Rate; Hydralazine; Hypertension; Levodopa; Male; Methyldopa; Rats	1975
Five years' treatment of Parkinson's disease with levodopa. Therapeutic results and survival of 100 patients. Annals of internal medicine, 1975, Volume: 83, Issue:4 Topics: Adult; Aged; Carbidopa; Female; Follow-Up Studies; Humans; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	1975
Optical resolution of N-acyl-DL-amino acids by preferential crystallization procedure. Preparation of L-DOPA and L-alpha-methyl DOPA. The Journal of organic chemistry, 1975, Nov-14, Volume: 40, Issue:23 Topics: Crystallization; Levodopa; Methyldopa; Optical Rotation	1975
Effects of chronic oral administration on the disposition of laevodopa and its major metabolites in the plasma of the rat. Xenobiotica; the fate of foreign compounds in biological systems, 1975, Volume: 5, Issue:10 Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Catecholamines; Homovanillic Acid; Levodopa; Male; Methyldopa; Rats; Time Factors; Vanilmandelic Acid	1975
[Effect of alpha-methyldopa on the inhibition by L-dopa of the hypothalamo-hypophyseal-adrenocortical system during hypoglycemic stress in humans]. Bollettino della Societa italiana di biologia sperimentale, 1975, Feb-28, Volume: 51, Issue:4 Topics: Adrenal Cortex; Adrenal Glands; Adult; Blood Glucose; Female; Humans; Hydrocortisone; Hypothalamus; Insulin; Levodopa; Male; Methyldopa; Pituitary Gland; Pituitary Gland, Anterior; Pituitary-Adrenal Function Tests	1975
[Pharmacologic study of adrenergic mechanisms of compensatory hypertrophy of the ovary]. Biulleten' eksperimental'noi biologii i meditsiny, 1975, Volume: 80, Issue:12 Topics: Animals; Castration; Chlorpromazine; Diethylstilbestrol; Disulfiram; Female; Follicle Stimulating Hormone; Levodopa; Methyldopa; Ovary; Phenytoin; Rats; Sympathetic Nervous System	1975
The dopamine hypothesis of schizophrenia. A critical analysis. Neuropsychobiology, 1975, Volume: 1, Issue:6 Topics: Acetylcholine; Amphetamine; Apomorphine; Cocaine; Dopamine; Electroconvulsive Therapy; gamma-Aminobutyric Acid; Humans; Levodopa; Methyldopa; Methyltyrosines; Models, Neurological; Psychoses, Substance-Induced; Schizophrenia; Tranquilizing Agents	1975
Medical modification of sensation. Journal of neurosurgery, 1976, Volume: 44, Issue:1 Topics: Adult; Denervation; Differential Threshold; Female; Glossopharyngeal Nerve; Humans; Levodopa; Male; Methyldopa; Middle Aged; Neural Pathways; Pain, Intractable; Peripheral Nerves; Sensation; Spinal Nerve Roots; Trigeminal Nerve; Vagus Nerve	1976
Effects of aging on LH and prolactin after LHRL L-dopa, methyl-dopa, and stress in male rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 151, Issue:3 Topics: Aging; Animals; Hypothalamus; Levodopa; Luteinizing Hormone; Male; Methyldopa; Pituitary Gland, Anterior; Prolactin; Rats; Stress, Physiological	1976
[Experiences in the treatment of Parkinsonism using a combination of L-dopa and alpha-methyldopa-hydrazine]. Ceskoslovenska neurologie a neurochirurgie, 1976, Volume: 39, Issue:2 Topics: Adult; Aged; Drug Combinations; Drug Evaluation; Drug Synergism; Humans; Hydrazines; Levodopa; Methyldopa; Middle Aged; Parkinson Disease	1976
Gout induced by L-dopa and decarboxylase inhibitors. Postgraduate medical journal, 1976, Volume: 52, Issue:606 Topics: Aged; Carbidopa; Carboxy-Lyases; Gout; Humans; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	1976
Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat. British journal of pharmacology, 1992, Volume: 105, Issue:3 Topics: Amidines; Animals; Benzophenones; Biogenic Monoamines; Brain; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Homovanillic Acid; Hypothalamus; Levodopa; Male; Methyldopa; Nitriles; Nitrophenols; Pyridones; Rats; Rats, Inbred Strains; Tolcapone	1992
High-performance liquid chromatography with electrochemical detection for the determination of levodopa, catecholamines and their metabolites in rat brain dialysates. Journal of chromatography, 1992, Mar-27, Volume: 575, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Caudate Nucleus; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Epinephrine; Homovanillic Acid; Injections, Intraperitoneal; Levodopa; Male; Methyldopa; Norepinephrine; Rats; Rats, Inbred Strains; Substantia Nigra	1992
Some parasympathetic neurons in the guinea-pig heart express aspects of the catecholaminergic phenotype in vivo. Cell and tissue research, 1990, Volume: 261, Issue:2 Topics: Animals; Catecholamines; Dopamine; Dopamine beta-Hydroxylase; Female; Ganglia, Autonomic; Guinea Pigs; Heart; Immunohistochemistry; Levodopa; Male; Methyldopa; Neurons; Norepinephrine; Pargyline; Phenotype; Serotonin; Sympathectomy, Chemical; Tyrosine 3-Monooxygenase	1990
The interaction of orally administered iron with levodopa and methyldopa therapy. The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:7 Topics: Administration, Oral; Drug Interactions; Ferric Compounds; Ferrous Compounds; Humans; Hydrogen-Ion Concentration; Levodopa; Methyldopa; Oxidation-Reduction; Spectrophotometry, Ultraviolet	1990
Fully automated high-performance liquid chromatographic assay for the analysis of free catecholamines in urine. Journal of chromatography, 1990, Aug-24, Volume: 530, Issue:1 Topics: Autoanalysis; Chromatography, High Pressure Liquid; Dopamine; Epinephrine; Humans; Hydrogen-Ion Concentration; Levodopa; Methyldopa; Norepinephrine; Quality Control	1990
Coulometric determination of levodopa, methyldopa and carbidopa. Farmaco (Societa chimica italiana : 1989), 1990, Volume: 45, Issue:9 Topics: Azo Compounds; Carbidopa; Electrochemistry; Levodopa; Methyldopa	1990
Magnitude of response to levodopa in Parkinson disease as it relates to peripheral and central measurements of levodopa and associated metabolites. Clinical neuropharmacology, 1989, Volume: 12, Issue:5 Topics: Aged; Carbidopa; Drug Combinations; Homovanillic Acid; Humans; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease	1989
Spectrophotometric determination of microquantities of Carbidopa, Levodopa and alpha-methyldopa using molybdatophosphoric acid. Pharmaceutica acta Helvetiae, 1989, Volume: 64, Issue:3 Topics: Carbidopa; Levodopa; Methyldopa; Molybdenum; Phosphoric Acids; Spectrophotometry, Ultraviolet	1989
Continuous oral administration of L-dihydroxyphenylalanine (L-DOPA) solution to patients with advanced Parkinson's disease. Clinical neuropharmacology, 1989, Volume: 12, Issue:4 Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Injections, Intravenous; Levodopa; Methyldopa; Parkinson Disease	1989
[Distribution of neurotensin-like immunoreactivity (NTLI) and neurotensin receptor in the rat brain and effects of various drugs on NTLI concentration and NT receptor in the rat cerebral cortex]. Nihon Naibunpi Gakkai zasshi, 1988, May-20, Volume: 64, Issue:5 Topics: Animals; Brain; Cerebral Cortex; Dopamine; Haloperidol; In Vitro Techniques; Injections, Intraventricular; Levodopa; Male; Methyldopa; Neuropeptides; Rats; Receptors, Neurotensin; Receptors, Neurotransmitter	1988
Pharmacokinetics of L-dopa in patients with Parkinson's disease. Advances in neurology, 1987, Volume: 45 Topics: Biotransformation; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disability Evaluation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Kinetics; Levodopa; Methyldopa; Parkinson Disease; Receptors, Dopamine; Receptors, Dopamine D2; Tiapamil Hydrochloride	1987
Inhibition of monoamine oxidase by 3,4-dihydroxyphenyl L-alanine and its analogues. Life sciences, 1987, Jan-26, Volume: 40, Issue:4 Topics: Dihydroxyphenylalanine; Droxidopa; Humans; In Vitro Techniques; Kynuramine; Levodopa; Methyldopa; Mitochondria; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Placenta; Stereoisomerism; Structure-Activity Relationship	1987
Repeated levodopa infusions in fluctuating Parkinson's disease: clinical and pharmacokinetic data. Clinical neuropharmacology, 1986, Volume: 9, Issue:2 Topics: Drug Administration Schedule; Drug Interactions; Female; Humans; Infusions, Parenteral; Kinetics; Levodopa; Male; Methyldopa; Middle Aged; Parkinson Disease; Time Factors	1986
Pharmacokinetics of levodopa and motor fluctuations. Advances in neurology, 1987, Volume: 45 Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Kinetics; Levodopa; Methyldopa; Motor Skills; Parkinson Disease	1987
The effect of L-DOPA on brain polysomes and protein synthesis: probable mediation by intracellular dopamine. Advances in neurology, 1974, Volume: 5 Topics: 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Carbon Radioisotopes; Decarboxylation; Depression, Chemical; Dihydroxyphenylalanine; Dopamine; Drug Interactions; Enzyme Inhibitors; Hydrazines; Leucine; Levodopa; Lysine; Male; Methyldopa; Nerve Tissue Proteins; Norepinephrine; Polyribosomes; Rats; S-Adenosylmethionine; Time Factors	1974
[The determination of bilirubin as azobilirubin in plasma and serum with the Greiner electronic selective analyzer GSA II (author's transl)]. Zeitschrift fur klinische Chemie und klinische Biochemie, 1974, Volume: 12, Issue:6 Topics: Ascorbic Acid; Azo Compounds; Bilirubin; Chemistry, Clinical; Diazonium Compounds; Epinephrine; Hemoglobins; Hemolysis; Histidine; Humans; Hyperlipidemias; Levodopa; Methyldopa; Norepinephrine; Rifampin; Spectrophotometry, Ultraviolet; Statistics as Topic; Tyrosine	1974
The effects of L-dopa and alpha-methyldopa on reflexes and sympathetic nerve function. European journal of pharmacology, 1974, Volume: 25, Issue:1 Topics: Animals; Atropine; Barbiturates; Benserazide; Blood Pressure; Carbidopa; Carotid Arteries; Dogs; Electric Stimulation; Heart Rate; Hindlimb; Levodopa; Methyldopa; Monoamine Oxidase Inhibitors; Neurons; Perfusion; Posture; Reflex; Regional Blood Flow; Sympathetic Nervous System; Vagotomy; Vagus Nerve	1974
3-O-Methyldopa in Parkinson's disease. Advances in neurology, 1974, Volume: 5 Topics: Antiparkinson Agents; Drug Antagonism; Drug Therapy, Combination; Humans; Levodopa; Methyldopa; Parkinson Disease; Time Factors; Trihexyphenidyl	1974
The "on-off" response to chronic L-DOPA treatment of Parkinsonism. Advances in neurology, 1974, Volume: 5 Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Confusion; Dietary Proteins; Enzyme Inhibitors; Female; Gait; Humans; Levodopa; Male; Methyldopa; Movement Disorders; Muscle Cramp; Parkinson Disease; Time Factors	1974
Effect of L-DOPA and analogues on central dopamine and noradrenaline mechanisms. Advances in neurology, 1974, Volume: 5 Topics: 5-Hydroxytryptophan; Acetamides; Animals; Apomorphine; Brain Chemistry; Clonidine; Corpus Striatum; Dopamine; Hydrazines; Levodopa; Methyldopa; Methyltyrosines; Movement; Nialamide; Norepinephrine; Octopamine; Rats; Receptors, Drug; Reflex; Reserpine; Spinal Cord; Stimulation, Chemical; Tyramine; Tyrosine	1974
Effects of 3,4-dihydroxyphenylpyruvic acid and L-glutamic acid on some pharmacokinetic parameters of L-dopa in the rat. The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:5 Topics: Animals; Biological Availability; Brain Chemistry; Dopamine; Drug Interactions; Glutamates; Homovanillic Acid; Kinetics; Levodopa; Male; Methyldopa; Motor Activity; Phenylpyruvic Acids; Rats	1980
[Catecholaminergic neuronal pathways in homeostatic control of blood circulating mass]. Bollettino della Societa italiana di biologia sperimentale, 1980, Dec-30, Volume: 56, Issue:24 Topics: Adrenergic alpha-Antagonists; Animals; Benserazide; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Diuresis; Levodopa; Methyldopa; Phentolamine; Rats; Thirst	1980
Effect of 1-DOPA on calcitonin secretion by thyroid C cells. Zeitschrift fur mikroskopisch-anatomische Forschung, 1983, Volume: 97, Issue:2 Topics: Animals; APUD Cells; Calcitonin; Calcium Gluconate; Cytoplasmic Granules; Guinea Pigs; Levodopa; Methyldopa; Microscopy, Electron; Rats; Thyroid Gland	1983
Catechol-O-methyltransferase and Parkinson's disease. Advances in neurology, 1984, Volume: 40 Topics: Animals; Brain; Catechol O-Methyltransferase; Corpus Striatum; Levodopa; Male; Methyldopa; Parkinson Disease; Propiophenones; Rats; Rats, Inbred Strains	1984
"On-off" phenomenon in Parkinson's disease. The New England journal of medicine, 1984, Jul-19, Volume: 311, Issue:3 Topics: Animals; Carbidopa; Humans; Levodopa; Methyldopa; Parkinson Disease	1984
Determination of the enantiomeric purity of levodopa, methyldopa, carbidopa and tryptophan by use of chiral mobile phase high-performance liquid chromatography. Journal of chromatography, 1983, Mar-04, Volume: 257, Issue:2 Topics: Capsules; Carbidopa; Chromatography, High Pressure Liquid; Copper; Copper Sulfate; Drug Contamination; Levodopa; Methyldopa; Phenylalanine; Stereoisomerism; Tablets; Tryptophan	1983
Influence of carbidopa, an aromatic amino acid decarboxylase inhibitor, on the development of autoimmune hemolytic anemia in NZB mice. Japanese journal of pharmacology, 1983, Volume: 33, Issue:2 Topics: Anemia, Hemolytic, Autoimmune; Animals; Body Weight; Carbidopa; Coombs Test; Female; Hematocrit; Levodopa; Male; Methyldopa; Mice; Mice, Inbred NZB	1983
Endogenous dopamine synthesis and dopa-decarboxylase activity in rat renal cortex. Molecular and cellular endocrinology, 1982, Volume: 27, Issue:1 Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Dopa Decarboxylase; Dopamine; Kidney Cortex; Kidney Glomerulus; Kinetics; Levodopa; Male; Methyldopa; Rats; Rats, Inbred Strains	1982
Catechol-O-methyltransferase inhibition by U-0521 increases striatal utilization of levodopa. Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 320, Issue:1 Topics: Animals; Catechol O-Methyltransferase Inhibitors; Catecholamines; Corpus Striatum; Dose-Response Relationship, Drug; Levodopa; Male; Methyldopa; Propiophenones; Rats; Rats, Inbred Strains; Time Factors	1982
Alpha-Monofluoromethyldopa (MFMD) in combination with L-DOPA Effects on tissue catecholamines and blood pressure in rats. Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 321, Issue:1 Topics: Animals; Blood Pressure; Catecholamines; Drug Interactions; Levodopa; Male; Methyldopa; Rats; Rats, Inbred Strains; Sodium Chloride	1982
[Catecholamines in the mechanism of the cardionecrotic action of acetaldehyde]. Biulleten' eksperimental'noi biologii i meditsiny, 1982, Volume: 94, Issue:12 Topics: Acetaldehyde; Animals; Catecholamines; Drug Synergism; Epinephrine; Heart; In Vitro Techniques; Levodopa; Male; Methyldopa; Methyltyrosines; Necrosis; Rats	1982
Catechol-O-methyltransferase activity: a determinant of levodopa response. Clinical pharmacology and therapeutics, 1980, Volume: 28, Issue:2 Topics: Aged; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Erythrocytes; Female; Humans; Kidney; Levodopa; Liver; Male; Methyldopa; Middle Aged; Parkinson Disease; Time Factors	1980
Irreversible inhibition of aromatic-L-amino acid decarboxylase by alpha-difluoromethyl-DOPA and metabolism of the inhibitor. Biochemical pharmacology, 1980, Sep-15, Volume: 29, Issue:18 Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Catechol O-Methyltransferase; Dihydroxyphenylalanine; Kidney; Levodopa; Methylation; Methyldopa; Pyridoxal Phosphate; Rats; Swine	1980
Quantitative microdialysis for studying the in vivo L-DOPA kinetics in blood and skeletal muscle of the dog. Pharmaceutical research, 1995, Volume: 12, Issue:5 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Proteins; Calibration; Dialysis; Dogs; Dopamine; Injections, Intramuscular; Injections, Intravenous; Levodopa; Male; Methyldopa; Microchemistry; Muscle, Skeletal; Protein Binding; Reference Standards; Reproducibility of Results; Tyrosine	1995
Early L-dopa treatment initially retards but later enhances dopamine receptor supersensitivity following unilateral dopamine denervation. Brain research, 1994, Sep-26, Volume: 658, Issue:1-2 Topics: Animals; Behavior, Animal; Denervation; Functional Laterality; Homovanillic Acid; Levodopa; Male; Methyldopa; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Rotation; Time Factors	1994
3-O-methyl-DOPA is not involved in the development of behavioral supersensitivity after repeated L-dopa administration in 6-OHDA lesioned rats. Behavioural brain research, 1994, Jul-29, Volume: 63, Issue:1 Topics: Animals; Apomorphine; Carbidopa; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Levodopa; Male; Methyldopa; Motor Activity; Oxidopamine; Rats; Rats, Wistar; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra	1994
The effect of pH on the suicide inactivation of frog epidermis tyrosinase. Biochimica et biophysica acta, 1994, Apr-13, Volume: 1205, Issue:2 Topics: Animals; Catechols; Enzyme Stability; Epidermis; Hydrogen-Ion Concentration; Kinetics; Levodopa; Methyldopa; Models, Biological; Monophenol Monooxygenase; Ranidae	1994
Black cartilage after therapy with levodopa and methyldopa. Archives of pathology & laboratory medicine, 1994, Volume: 118, Issue:5 Topics: Aged; Aged, 80 and over; Cartilage, Articular; Dose-Response Relationship, Drug; Female; Humans; Intervertebral Disc; Levodopa; Male; Methyldopa; Microscopy, Electron; Parkinson Disease; Pigmentation; Ribs; Time Factors	1994
Immunogenicity studies of a synthetic antigen of alpha methyl dopa. Immunopharmacology and immunotoxicology, 1993, Volume: 15, Issue:5 Topics: Animals; Antibody Formation; Antigens; Autoantibodies; Autoimmunity; Catechols; Haptens; Immunization; Levodopa; Liver; Male; Methyldopa; Rabbits; Serum Albumin	1993
Simultaneous monitoring of levodopa, dopamine and their metabolites in skeletal muscle and subcutaneous tissue in different pharmacological conditions using microdialysis. Journal of pharmaceutical and biomedical analysis, 1993, Volume: 11, Issue:7 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Chromatography, High Pressure Liquid; Dialysis; Dogs; Dopamine; Electrochemistry; Extracellular Space; Injections, Intravenous; Levodopa; Male; Methyldopa; Muscles; Skin	1993
Circadian phase dependent pharmacokinetics of L-dopa, its main metabolites (3-OMD, HVA, DOPAC) and carbidopa in rats. Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Area Under Curve; Carbidopa; Circadian Rhythm; Half-Life; Homovanillic Acid; Levodopa; Male; Methyldopa; Rats; Rats, Wistar	1996
Automated determination of levodopa and carbidopa in plasma by high-performance liquid chromatography-electrochemical detection using an on-line flow injection analysis sample pretreatment unit. Journal of chromatography. B, Biomedical sciences and applications, 1997, Sep-26, Volume: 698, Issue:1-2 Topics: Animals; Antiparkinson Agents; Automation; Carbidopa; Chromatography, High Pressure Liquid; Dogs; Electrochemistry; Flow Injection Analysis; Levodopa; Male; Methyldopa; Reference Standards	1997
Direct high-performance liquid chromatographic determination of the enantiomeric purity of levodopa and methyldopa: comparison with pharmacopoeial polarimetric methods. Journal of pharmaceutical and biomedical analysis, 1999, Volume: 19, Issue:3-4 Topics: Chromatography, High Pressure Liquid; Czech Republic; Europe; Evaluation Studies as Topic; Levodopa; Ligands; Methyldopa; Optical Rotation; Pharmacopoeias as Topic; Reproducibility of Results; Sensitivity and Specificity; Solvents; Stereoisomerism; Teicoplanin	1999
Pharmacogenetics of catechol-O-methyltransferase: frequency of low activity allele in a Ghanaian population. Human mutation, 2000, Volume: 16, Issue:5 Topics: Adolescent; Adult; Alleles; Asia, Western; Catechol O-Methyltransferase; Enzyme Activation; Female; Gene Frequency; Ghana; Humans; Kenya; Levodopa; Male; Methyldopa; Middle Aged	2000
Effect of alpha-methyldopa on pentoxyresorufin O-dealkylation in liver microsomes from rats treated with phenobarbital. Archives of biochemistry and biophysics, 2001, Aug-01, Volume: 392, Issue:1 Topics: Animals; Ascorbic Acid; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1 Inhibitors; Dopamine; Enzyme Inhibitors; Glutathione; Levodopa; Lipid Peroxidation; Male; Methyldopa; Microsomes, Liver; NADP; Oxazines; Phenobarbital; Rats; Rats, Wistar	2001
Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice. The European journal of neuroscience, 2002, Volume: 15, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthesia; Animals; Carbidopa; Catechol O-Methyltransferase; Corpus Striatum; Dopamine; Dopamine Agents; Female; Homovanillic Acid; Levodopa; Male; Methoxyhydroxyphenylglycol; Methyldopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Norepinephrine	2002
Binding site of salsolinol: its properties in different regions of the brain and the pituitary gland of the rat. Neurochemistry international, 2003, Volume: 42, Issue:1 Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Binding Sites; Binding, Competitive; Brain; Carbidopa; Clonidine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Enzyme Inhibitors; Female; Isoquinolines; Kinetics; Lactation; Levodopa; Male; Mazindol; Median Eminence; Methyldopa; Pituitary Gland; Pituitary Gland, Posterior; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Reserpine	2003
Analysis of L-dopa in human serum. BioTechniques, 2002, Volume: 33, Issue:5 Topics: Antiparkinson Agents; Chromatography, Affinity; Edetic Acid; Formates; Humans; Hydrogen-Ion Concentration; Levodopa; Methyldopa; Parkinson Disease; Reference Standards	2002
Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone). Pharmacology & toxicology, 2003, Volume: 92, Issue:6 Topics: Acetophenones; Administration, Oral; Animals; Antiparkinson Agents; Benserazide; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Drug Interactions; Erythrocytes; Humans; In Vitro Techniques; Levodopa; Liver; Methylation; Methyldopa; Microdialysis; Rats; Rats, Wistar	2003
[ACTION OF CERTAIN L-DOPA/5-HTP DECARBOXYLASE INHIBITORS ON HYPOTHALAMO-HYPOPHYIAL NEUROSECRETION IN THE RAT]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1964, Volume: 158 Topics: 5-Hydroxytryptophan; Acetylcholine; Aromatic Amino Acid Decarboxylase Inhibitors; Carboxy-Lyases; Cinnamates; Dopa Decarboxylase; Enzyme Inhibitors; Hypothalamo-Hypophyseal System; Levodopa; Methyldopa; Neurosecretion; Pharmacology; Piperidines; Rats; Research; Serotonin	1964
Mediated exodus of L-dopa from human epidermal Langerhans cells. Amino acids, 2004, Volume: 26, Issue:2 Topics: Adult; Amino Acids; Biological Transport; Biopsy; Epidermal Cells; Epidermis; Humans; Langerhans Cells; Levodopa; Methyldopa; Time Factors	2004
Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology, 2005, Volume: 49, Issue:6 Topics: Animals; Aorta; Blotting, Northern; Brain; Chromatography, High Pressure Liquid; Dopamine; Female; Gene Expression Regulation; Hydroxyindoleacetic Acid; Kidney; Levodopa; Liver; Lung; Male; Methyldopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Myocardium; Nonlinear Dynamics; Norethandrolone; Pancreas; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sex Factors; Spleen; Time Factors; Tryptophan Hydroxylase	2005
Comparative analysis of Cryptococcus neoformans acid-resistant particles generated from pigmented cells grown in different laccase substrates. Fungal genetics and biology : FG & B, 2005, Volume: 42, Issue:12 Topics: Chromatography, High Pressure Liquid; Cryptococcus neoformans; Cytoplasmic Granules; Electron Spin Resonance Spectroscopy; Epinephrine; Levodopa; Melanins; Methyldopa; Microscopy, Electron, Transmission; Norepinephrine; Organelles; Pigments, Biological	2005
Evidence for L-dopa incorporation into cell proteins in patients treated with levodopa. Journal of neurochemistry, 2006, Volume: 98, Issue:4 Topics: Aged; Antiparkinson Agents; Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Hydrolysis; Levodopa; Lymphocytes; Male; Methyldopa; Parkinson Disease; Proteins	2006
Simultaneous kinetic-spectrophotometric determination of carbidopa, levodopa and methyldopa in the presence of citrate with the aid of multivariate calibration and artificial neural networks. Analytica chimica acta, 2007, Nov-12, Volume: 603, Issue:2 Topics: Calibration; Carbidopa; Citric Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Levodopa; Methyldopa; Neural Networks, Computer; Spectrophotometry	2007
Quantitative analysis of levodopa, carbidopa and methyldopa in human plasma samples using HPLC-DAD combined with second-order calibration based on alternating trilinear decomposition algorithm. Talanta, 2010, May-15, Volume: 81, Issue:3 Topics: Algorithms; Calibration; Carbidopa; Chemistry Techniques, Analytical; Chromatography; Chromatography, High Pressure Liquid; Humans; Levodopa; Methyldopa; Models, Chemical; Reproducibility of Results; Solvents	2010
The timing of administration, dose dependence and efficacy of dopa decarboxylase inhibitors on the reversal of motor disability produced by L-DOPA in the MPTP-treated common marmoset. European journal of pharmacology, 2010, Jun-10, Volume: 635, Issue:1-3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Callithrix; Carbidopa; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Enzyme Inhibitors; Female; Levodopa; Male; Methyldopa; Motor Activity; Movement Disorders	2010
Levodopa and 3-OMD levels in Parkinson patients treated with Duodopa. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2010, Volume: 20, Issue:10 Topics: Antiparkinson Agents; Drug Therapy, Combination; Duodenum; Female; Home Infusion Therapy; Homocysteine; Humans; Infusions, Parenteral; Levodopa; Male; Methyldopa; Parkinson Disease	2010
Determination of L-dopa, carbidopa, 3-O-methyldopa and entacapone in human plasma by HPLC-ED. Journal of pharmaceutical and biomedical analysis, 2011, Feb-20, Volume: 54, Issue:3 Topics: Antiparkinson Agents; Calibration; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Drug Combinations; Humans; Levodopa; Methyldopa; Nitriles; Reproducibility of Results; Solid Phase Extraction	2011
Simultaneous quantitation of levodopa and 3-O-methyldopa in human plasma by HPLC-ESI-MS/MS: application for a pharmacokinetic study with a levodopa/benserazide formulation. Journal of pharmaceutical and biomedical analysis, 2011, Dec-15, Volume: 56, Issue:5 Topics: Benserazide; Calibration; Chromatography, High Pressure Liquid; Humans; Levodopa; Methyldopa; Quality Control; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry	2011
Development and validation of a high-performance liquid chromatography-electrospray ionization-MS/MS method for the simultaneous quantitation of levodopa and carbidopa in human plasma. Journal of mass spectrometry : JMS, 2011, Volume: 46, Issue:9 Topics: Administration, Oral; Carbidopa; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Levodopa; Male; Methyldopa; Reproducibility of Results; Sensitivity and Specificity; Tablets; Tandem Mass Spectrometry	2011
Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity. Neurochemical research, 2012, Volume: 37, Issue:9 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Cell-Free System; Cells, Cultured; Cyclooxygenase Inhibitors; Dopamine Agents; Dopaminergic Neurons; Glutathione; Indomethacin; Levodopa; Meloxicam; Methyldopa; Mice; Neurons; Neuroprotective Agents; Quinones; Sympatholytics; Thiazines; Thiazoles	2012
Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease. Cerebral cortex (New York, N.Y. : 1991), 2014, Volume: 24, Issue:11 Topics: Aged; Antiparkinson Agents; Bayes Theorem; Brain Waves; Case-Control Studies; Deep Brain Stimulation; Electroencephalography; Electromyography; Female; Fourier Analysis; Humans; Image Processing, Computer-Assisted; Levodopa; Magnetic Resonance Imaging; Male; Methyldopa; Middle Aged; Motor Cortex; Muscle, Skeletal; Neural Pathways; Oxygen; Parkinson Disease; Time Factors	2014
Levodopa-related cysteinyl-glycine and cysteine reduction with and without catechol-O-methyltransferase inhibition in Parkinson's disease patients. Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:6 Topics: Aged; Analysis of Variance; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase; Catechols; Chromatography, Reverse-Phase; Cysteine; Dipeptides; Drug Delivery Systems; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Nitriles; Parkinson Disease; Time Factors	2014