Page last updated: 2024-08-17

levodopa and glutamic acid

levodopa has been researched along with glutamic acid in 101 studies

Research

Studies (101)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (3.96)	18.7374
1990's	18 (17.82)	18.2507
2000's	39 (38.61)	29.6817
2010's	30 (29.70)	24.3611
2020's	10 (9.90)	2.80

Authors

Authors	Studies
Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H	1
Cha, SH; Chairoungdua, A; Endou, H; Enomoto, A; Goya, T; Kanai, Y; Kim, DK; Kim, JY; Kobayashi, Y; Matsuo, H	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Persson, B; Rubenson, A; Sillén, U	1
Brodin, L; Grillner, S; Rovainen, CM	1
Commissiong, JW	1
Misu, Y; Miyamae, T; Okumura, Y; Ueda, H; Yue, JL	1
Alexiuk, NA; Green-Johnson, J; Ryan, E; Vriend, J	1
de Groat, WC; Roppolo, JR; Yoshiyama, M	1
Kanazawa, I; Kimura, M; Murata, M	1
Lange, KW; Riederer, P; Youdim, MB	1
Akaike, A; Goshima, Y; Misu, Y; Miyamae, T; Nakamura, S; Ohno, K	1
Biggs, C; Fowler, L; Starr, M; Whitton, P	1
Misu, Y; Miyamae, T; Ueda, H; Yue, JL	1
Kaur, S; Starr, BS; Starr, MS	1
Fujita, K; Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T; Nishihama, M; Okumura, F	1
Akaike, A; Cheng, N; Goshima, Y; Kaneko, S; Kouchiyama, H; Kume, T; Maeda, T; Misu, Y; Satoh, M; Ueda, M	1
Duport, S; Grau, G; Muller, D; Parisi, L; Robert, F; Stoppini, L	1
Busel, BI; Sanzharovsky, AV; Storozhuk, VM	1
Blanchet, PJ; Chase, TN; Del Dotto, P; van den Munckhof, P; Verhagen Metman, L	1
Barbeau, H; Bouyer, L; Brustein, E; Chau, C; Giroux, N; Reader, TA; Rossignol, S	1
Arai, N; Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T	1
Gordon, FJ; Ito, S; Sved, AF	1
Rascol, O	1
Arai, N; Fujita, K; Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T; Ohshima, E; Shimizu, M; Sugiyama, Y; Suzuki, F	1
Evert, BO; Klockgether, T; Kovar, KA; Rundfeldt, C; Schulz, JB; Seyfried, J; Wüllner, U	1
Grace, AA; Onn, SP; West, AR	1
Bernardi, G; Calabresi, P; Centonze, D	1
Chase, TN; Oh, JD	2
Arai, N; Fujita, K; Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T; Ohshima, E; Suzuki, F	1
Arai, N; Fujita, K; Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T; Ohshima, E; Sasaki, Y; Suzuki, F	1
Baas, H	1
Ebinger, G; Jonkers, N; Michotte, Y; Sarre, S	1
Djaldetti, R; Melamed, E; Merims, D; Sherki, Y; Ziv, I	1
Archer, T; Fredriksson, A; Palomo, T	1
Blanchet, PJ; Chase, TN; Metman, LV	1
Beani, L; Bianchi, C; Marti, M; Mela, F; Morari, M; Paganini, F; Stocchi, S	1
Goshima, Y; Hashimoto, M; Miyamae, T; Yamamoto, I	1
Ninan, I; Wang, RY	1
Bari, M; Battista, N; Bernardi, G; Calabresi, P; Centonze, D; Finazzi-Agrò, A; Gubellini, P; Maccarrone, M; Picconi, B	1
DENGLER, HJ; RAUCHS, E; RUMMEL, W	1
Bédard, PJ; Bélanger, N; Darré, A; Grégoire, L; Hadj Tahar, A; Meltzer, L	1
Kase, H; Ochi, M; Shiozaki, S	1
Bernardi, G; Calabresi, P; Centonze, D; Picconi, B; Rossi, S	1
Fan, SW; Hwa, KY; Hwu, WL; Lee, YM; Lu, MY	1
Guillet, B; Kerkerian-Le Goff, L; Melon, C; Robelet, S; Salin, P	1
Bamford, NS; Joyce, JA; Meshul, CK; Moore, C; Palmiter, RD; Robinson, S	1
Bielicki, G; Chassain, C; Donnat, JP; Durif, F; Eschalier, A; Renou, JP	1
Baunez, C; Bernardi, G; Calabresi, P; Centonze, D; Gubellini, P; Picconi, B; Pisani, A; Rossi, S	1
Fukumoto, D; Harada, N; Kakiuchi, T; Nishiyama, S; Tsukada, H	1
Holmer, HK; Keyghobadi, M; Meshul, CK; Moore, C	1
Aksu, M; Bara-Jimenez, W; Chase, TN; Dimitrova, TD; Sherzai, A	1
Marti, M; Morari, M; Trapella, C; Viaro, R	1
Durif, F; Fraix, V; Kickler, N; Krack, P; Krainik, A; Lamalle, L; Lebas, JF; Pollak, P; Rémy, C; Segebarth, C	1
Cenci, MA; Danysz, W; Dekundy, A; Marti, M; Mela, F; Morari, M	1
Gardoni, F	1
Danysz, W; Dekundy, A; Gravius, A; Morè, L; Nagel, J; Pietraszek, M	1
Mastaglia, FL; Rodrigues, JP; Stell, R; Thickbroom, GW; Walters, SE	1
Marti, M; Morari, M; Trapella, C	1
Cenci, MA; Danysz, W; Dekundy, A; Mela, F; Recchia, A; Rylander, D	1
Bilbe, G; Di Paolo, T; Gasparini, F; Gomez-Mancilla, B; Grégoire, L; Hornykiewicz, O; Johns, DR; Morissette, M; Ouattara, B; Rajput, A; Rajput, AH; Vranesic, I	1
Ahmad, KA; Rose, MF; Thaller, C; Zoghbi, HY	1
Bielicki, G; Chassain, C; Durif, F; Keller, C; Renou, JP	1
Jeng, W; Ramkissoon, A; Wells, PG	1
Bishop, C; Button, T; Dupre, KB; Eskow Jaunarajs, KL; Ostock, CY; Savage, LM; Wolf, W	1
Dziubina, A; Gołembiowska, K	2
Bido, S; Cenci, MA; Marti, M; Mela, F; Morari, M	1
Amalric, M; Blobaum, AL; Bode, J; Bridges, TM; Bubser, M; Conn, PJ; Daniels, JS; Dickerson, JW; Engers, DW; Hopkins, CR; Italiano, K; Jadhav, S; Jones, CK; Lindsley, CW; Morrison, RD; Niswender, CM; Thompson, AD; Turle-Lorenzo, N	1
Feng, Z; Gorelenkova, O; Yang, J; Zheng, M	1
Ballaz, S; Fuentes, A; Morales, I; Obeso, JA; Rodriguez, M	1
Gluck, MA; Herzallah, MM; Moustafa, AA	1
Bezard, E; Brambilla, R; Calabresi, P; Fasano, S; Guerrini, R; Li, Q; Marti, M; Morari, M; Morella, I; Rodi, D; Simonato, M; Tozzi, A	1
Gerhardt, GA; Lundblad, M; Nevalainen, N; Strömberg, I	1
Morales, I; Rodriguez, M; Sabate, M	1
Ivanova, SA; Loonen, AJ	1
Auberson, YP; Budri, M; Calcagno, M; Dekundy, A; Mabrouk, OS; Mela, F; Morari, M; Parsons, CG; Viaro, R	1
Chae, Y; Choo, HJ; Doo, AR; Kim, SN; Lee, B; Lee, H; Park, HJ; Park, JJ; Park, JY; Shim, I	1
di Marzo, V; Freestone, PS; Guatteo, E; Lipski, J; Mercuri, NB; Piscitelli, F	1
Ampe, B; Aourz, N; Bentea, E; De Deurwaerdère, P; El Arfani, A; Massie, A; Michotte, Y; Sarre, S; Smolders, I; Van Eeckhaut, A	1
Amalric, M	1
Arcuri, L; Brugnoli, A; Mercatelli, D; Morari, M; Paolone, G	1
Alvarsson, A; Kadkhodaei, B; Millan, MJ; Perlmann, T; Schintu, N; Stan, TL; Svenningsson, P; Zhang, X	1
Brugnoli, A; Morari, M; Napolitano, F; Usiello, A	1
Bezard, E; Cenci, MA; Conn, PJ; Fieblinger, T; Francardo, V; Greengard, P; Ko, WK; Li, Q; Lindsley, CW; Neubig, RR; Plotkin, JL; Shen, W; Surmeier, DJ; Wess, J; Xie, Z	1
McCreary, AC; Newman-Tancredi, A; Varney, MA	1
Asensio, MJ; García-Sanz, P; Herranz, AS; Moratalla, R; Solís, O	1
Bishop, C; Conti, MM; George, JA; Goldenberg, AA; Lindenbach, D; Melikhov-Sosin, M; Nuss, EE; Ostock, CY	1
Cao, X; Chen, G; Han, C; Ma, K; Nie, S; Papa, SM; Wang, T; Xiong, N; Xu, Y; Zhang, Z	1
Gardoni, F; Mellone, M	1
Bonizzoni, E; Cattaneo, C; Jost, WH	1
Mannoury-la-Cour, C; Mantas, I; Millan, MJ; Svenningsson, P; Yang, Y; Zhang, X	1
Bastioli, G; Caccia, C; Calabresi, P; Cardinale, A; Ghiglieri, V; Keywood, C; Mazzocchetti, P; Melloni, E; Mosci, P; Padoani, G; Picconi, B; Sciaccaluga, M; Tozzi, A; Vailati, S	1
Cuboni, E; Di Giovanni, G; Fedele, E; Galati, S; Grandi, LC; Kaelin-Lang, A; Orban, G; Salvadè, A; Song, W; Stefani, A	1
Brugnoli, A; Morari, M; Pisanò, CA	1
Furlong, TM; Gibson, AS; Keefe, KA	1
Antinora, C; Brandon, MP; Caron, MG; Chakravarty, MM; Duriez, P; El Mestikawy, S; Favier, M; Gallino, D; Germann, J; Gorwood, P; Gratton, A; Herzallah, MM; Jacobsen, JP; Janickova, H; Justo, D; Kang, JI; Kljakic, O; Meng, XQ; Moquin, L; Natsheh, JY; Neto, PR; Pascoal, TA; Prado, MA; Prado, VF; Raulic, S; Runtz, L; Vigneault, E	1
Frouni, I; Huot, P	1
Aguirre-Pérez, A; Alfaro-Rodriguez, A; Arias-Montaño, JA; Avila-Luna, A; Bueno-Nava, A; Gálvez-Rosas, A; Hidalgo-Bravo, A; Ríos, C	1
Liu, M; Tuo, J; Xu, Z; Yu, C; Zhang, F; Zhang, J; Zhang, L	1

Reviews

14 review(s) available for levodopa and glutamic acid

Article	Year
Recent advances in pharmacological therapy of Parkinson's disease. Advances in neurology, 1993, Volume: 60 Topics: Antiparkinson Agents; Dopamine Agents; Droxidopa; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Levodopa; NAD; Neurologic Examination; Parkinson Disease; Receptors, Dopamine	1993
Stimulation of basal and L-DOPA-induced motor activity by glutamate antagonists in animal models of Parkinson's disease. Neuroscience and biobehavioral reviews, 1997, Volume: 21, Issue:4 Topics: Animals; Antiparkinson Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Motor Activity; Parkinson Disease, Secondary; Rats; Stimulation, Chemical	1997
L-dopa-induced peak-dose dyskinesias in patients with Parkinson's disease: a clinical pharmacologic approach. Movement disorders : official journal of the Movement Disorder Society, 1999, Volume: 14 Suppl 1 Topics: Antiparkinson Agents; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; Narcotics; Norepinephrine; Parkinson Disease; Receptors, Dopamine; Serotonin	1999
Dopamine-mediated regulation of striatal neuronal and network interactions. Trends in neurosciences, 2000, Volume: 23, Issue:10 Suppl Topics: Animals; Antiparkinson Agents; Corpus Striatum; Dopamine; Glutamic Acid; Humans; Levodopa; Motor Activity; Muscle Tonus; Nerve Net; Neurons; Receptors, Dopamine; Signal Transduction	2000
Electrophysiology of dopamine in normal and denervated striatal neurons. Trends in neurosciences, 2000, Volume: 23, Issue:10 Suppl Topics: Animals; Antiparkinson Agents; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Electrophysiology; Glutamic Acid; Humans; Levodopa; Models, Neurological; Neurons; Parkinson Disease	2000
Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism. Trends in neurosciences, 2000, Volume: 23, Issue:10 Suppl Topics: Animals; Antiparkinson Agents; Corpus Striatum; Dopamine; Glutamic Acid; Humans; Levodopa; Models, Neurological; Neurons, Efferent; Parkinsonian Disorders; Phosphotransferases; Receptors, Dopamine; Receptors, Glutamate; Signal Transduction	2000
Dyskinesia in Parkinson's disease. Pathophysiology and clinical risk factors. Journal of neurology, 2000, Volume: 247 Suppl 4 Topics: Corpus Striatum; Drug Therapy; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; Neural Pathways; Neuropeptides; Parkinson Disease; Receptors, Dopamine; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Risk Factors	2000
Glutamate-mediated striatal dysregulation and the pathogenesis of motor response complications in Parkinson's disease. Amino acids, 2002, Volume: 23, Issue:1-3 Topics: Animals; Antiparkinson Agents; Corpus Striatum; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; Motor Activity; Parkinson Disease; Receptors, Cell Surface	2002
Renaissance of amantadine in the treatment of Parkinson's disease. Advances in neurology, 2003, Volume: 91 Topics: Amantadine; Animals; Antiparkinson Agents; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; Parkinson Disease; Receptors, N-Methyl-D-Aspartate; Treatment Outcome	2003
MAGUK proteins: new targets for pharmacological intervention in the glutamatergic synapse. European journal of pharmacology, 2008, May-06, Volume: 585, Issue:1 Topics: Alzheimer Disease; Animals; Antiparkinson Agents; Chronic Disease; Disks Large Homolog 4 Protein; Dyskinesia, Drug-Induced; Glutamic Acid; Guanylate Kinases; Humans; Huntington Disease; Intracellular Signaling Peptides and Proteins; Levodopa; Membrane Proteins; Pain; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Stroke; Synapses	2008
New insights into the mechanism of drug-induced dyskinesia. CNS spectrums, 2013, Volume: 18, Issue:1 Topics: Antiparkinson Agents; Cerebral Cortex; Corpus Striatum; Dyskinesia, Drug-Induced; GABAergic Neurons; Glutamic Acid; Humans; Levodopa; Neural Pathways; Thalamus	2013
Targeting metabotropic glutamate receptors (mGluRs) in Parkinson's disease. Current opinion in pharmacology, 2015, Volume: 20 Topics: Animals; Antiparkinson Agents; Basal Ganglia; Dopamine; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; Molecular Targeted Therapy; Parkinson Disease; Receptors, Metabotropic Glutamate	2015
Glutamate modulation for the treatment of levodopa induced dyskinesia: a brief review of the drugs tested in the clinic. Neurodegenerative disease management, 2022, Volume: 12, Issue:4 Topics: Antiparkinson Agents; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; N-Methylaspartate; Parkinson Disease	2022
Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation. Frontiers in immunology, 2023, Volume: 14 Topics: Aged; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; Middle Aged; N-Methylaspartate; Neuroinflammatory Diseases; Parkinson Disease; Quality of Life; Receptors, N-Methyl-D-Aspartate	2023

Trials

3 trial(s) available for levodopa and glutamic acid

Article	Year
Glutamate release inhibition ineffective in levodopa-induced motor complications. Movement disorders : official journal of the Movement Disorder Society, 2006, Volume: 21, Issue:9 Topics: Aged; Antiparkinson Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Riluzole; Treatment Outcome	2006
Spike-timing-related plasticity is preserved in Parkinson's disease and is enhanced by dopamine: evidence from transcranial magnetic stimulation. Neuroscience letters, 2008, Dec-19, Volume: 448, Issue:1 Topics: Acyclovir; Aged; Analysis of Variance; Dopamine; Dopamine Agents; Electric Stimulation; Evoked Potentials, Motor; Female; Glutamic Acid; Humans; Levodopa; Male; Middle Aged; Motor Cortex; Parkinson Disease; Reaction Time; Transcranial Magnetic Stimulation	2008
Long-Term Efficacy of Safinamide on Symptoms Severity and Quality of Life in Fluctuating Parkinson's Disease Patients. Journal of Parkinson's disease, 2020, Volume: 10, Issue:1 Topics: Activities of Daily Living; Aged; Alanine; Antiparkinson Agents; Benzylamines; Double-Blind Method; Drug Therapy, Combination; Dyskinesias; Female; Glutamic Acid; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase Inhibitors; Outcome Assessment, Health Care; Parkinson Disease; Quality of Life; Severity of Illness Index	2020

Other Studies

84 other study(ies) available for levodopa and glutamic acid

Article	Year
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. The Journal of biological chemistry, 2001, May-18, Volume: 276, Issue:20 Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis	2001
The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics, 2002, Volume: 79, Issue:1 Topics: Amino Acid Sequence; Amino Acid Transport Systems, Neutral; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 6; Humans; Molecular Sequence Data; Oocytes; Rats; Sequence Analysis, DNA; Sequence Homology; Xenopus laevis	2002
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Central effects of baclofen on the L-dopa induced hyperactive urinary bladder of the rat. Naunyn-Schmiedeberg's archives of pharmacology, 1985, Volume: 330, Issue:3 Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Injections, Intraventricular; Levodopa; Male; Naloxone; Rats; Rats, Inbred Strains; Substance P; Urinary Bladder	1985
N-Methyl-D-aspartate (NMDA), kainate and quisqualate receptors and the generation of fictive locomotion in the lamprey spinal cord. Brain research, 1985, Jan-28, Volume: 325, Issue:1-2 Topics: Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; Lampreys; Levodopa; Locomotion; Receptors, AMPA; Receptors, Cell Surface; Receptors, Drug; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord	1985
The synthesis and metabolism of catecholamines in the spinal cord of the rat after acute and chronic transections. Brain research, 1985, Nov-11, Volume: 347, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catecholamines; Cordotomy; Dopamine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homovanillic Acid; Levodopa; Norepinephrine; Rats; Rats, Inbred Strains; Spinal Cord	1985
Altered tonic L-3,4-dihydroxyphenylalanine systems in the nucleus tractus solitarii and the rostral ventrolateral medulla of spontaneously hypertensive rats. Neuroscience, 1995, Volume: 67, Issue:1 Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Biogenic Monoamines; Blood Pressure; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Heart Rate; Hypertension; Levodopa; Male; Medulla Oblongata; Microdialysis; Microinjections; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Solitary Nucleus; Tyrosine 3-Monooxygenase	1995
Determination of amino acids and monoamine neurotransmitters in caudate nucleus of seizure-resistant and seizure-prone BALB/c mice. Journal of neurochemistry, 1993, Volume: 60, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Animals; Biogenic Monoamines; Caudate Nucleus; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Homovanillic Acid; Hydrazines; Hydroxyindoleacetic Acid; Levodopa; Mice; Mice, Inbred BALB C; Seizures; Serotonin; Tyrosine 3-Monooxygenase	1993
Interactions between glutamatergic and monoaminergic systems controlling the micturition reflex in the urethane-anesthetized rat. Brain research, 1994, Mar-14, Volume: 639, Issue:2 Topics: Anesthesia; Animals; Apomorphine; Biogenic Monoamines; Dizocilpine Maleate; Female; Fenclonine; Glutamates; Glutamic Acid; Levodopa; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Reflex; Reserpine; Urethane; Urination	1994
Roles of dopamine and its receptors in generation of choreic movements. Advances in neurology, 1993, Volume: 60 Topics: Afferent Pathways; Animals; Brain Mapping; Cerebral Cortex; Choline O-Acetyltransferase; Chorea; Corpus Striatum; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Levodopa; Macaca; Neurons; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Substantia Nigra; Synapses; Tyrosine 3-Monooxygenase	1993
L-dopa induces Ca(2+)-dependent and tetrodotoxin-sensitive release of endogenous glutamate from rat striatal slices. Brain research, 1993, Jul-16, Volume: 617, Issue:1 Topics: Animals; Calcium; Corpus Striatum; Glutamates; Glutamic Acid; In Vitro Techniques; Levodopa; Male; Rats; Rats, Wistar; Tetrodotoxin	1993
Effects of glutamate antagonists on nigral dopamine release in the reserpine-treated rat. Biochemical Society transactions, 1996, Volume: 24, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Methyltyrosine; Animals; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Methyltyrosines; Raclopride; Rats; Reserpine; Salicylamides; Substantia Nigra	1996
Altered basal release and pressor effect of L-DOPA in the rostral ventrolateral medulla of spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. Supplement, 1995, Volume: 22, Issue:1 Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Blood Pressure; Dopamine Agents; Glutamic Acid; Heart Rate; Hypertension; Levodopa; Male; Medulla Oblongata; Microdialysis; Microinjections; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrodotoxin; Tyrosine; Tyrosine 3-Monooxygenase	1995
An L-DOPA-like depressor action of L-threo-dihydroxyphenyl-serine in the rat caudal ventrolateral medulla. Life sciences, 1997, Volume: 61, Issue:12 Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Droxidopa; Glutamic Acid; Heart Rate; Levodopa; Male; Medulla Oblongata; Microinjections; Organ Specificity; Rats; Rats, Wistar	1997
L-DOPA neurotoxicity is mediated by glutamate release in cultured rat striatal neurons. Brain research, 1997, Oct-10, Volume: 771, Issue:1 Topics: Animals; Calcium; Cell Death; Cells, Cultured; Corpus Striatum; Culture Media; Fetus; Glutamic Acid; Levodopa; Magnesium; Neurons; Neurotoxins; Rats; Rats, Wistar; Tetrodotoxin	1997
An in vitro blood-brain barrier model: cocultures between endothelial cells and organotypic brain slice cultures. Proceedings of the National Academy of Sciences of the United States of America, 1998, Feb-17, Volume: 95, Issue:4 Topics: Animals; Blood-Brain Barrier; Culture Techniques; Dialysis; Dopamine; Electrophysiology; Endothelium, Vascular; Freeze Fracturing; Glutamic Acid; Hippocampus; Levodopa; Mice; Models, Biological; Picrotoxin; Rats; Synapses	1998
Interaction between dopamine and glutamate in the sensorimotor cortex during conditioned placing reaction. Neuroscience, 1998, Volume: 85, Issue:2 Topics: Amphetamine; Animals; Behavior, Animal; Cats; Conditioning, Classical; Dopamine; Glutamic Acid; Haloperidol; Levodopa; Male; Neocortex	1998
Blockade of glutamatergic transmission as treatment for dyskinesias and motor fluctuations in Parkinson's disease. Amino acids, 1998, Volume: 14, Issue:1-3 Topics: Amantadine; Clinical Trials as Topic; Controlled Clinical Trials as Topic; Dextromethorphan; Dextrorphan; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Levodopa; Movement Disorders; Parkinson Disease; Psychomotor Performance; Receptors, N-Methyl-D-Aspartate	1998
Pharmacological activation and modulation of the central pattern generator for locomotion in the cat. Annals of the New York Academy of Sciences, 1998, Nov-16, Volume: 860 Topics: 5-Hydroxytryptophan; Animals; Cats; Clonidine; Denervation; Dopamine Agents; Electromyography; Excitatory Amino Acid Agonists; Glutamic Acid; Levodopa; Locomotion; Methoxamine; Motor Neurons; Muscle, Skeletal; N-Methylaspartate; Norepinephrine; Periodicity; Reflex; Serotonin; Spinal Cord; Sympatholytics; Sympathomimetics; Synaptic Transmission	1998
[Is endogenously released DOPA itself an upstream factor for increase in glutamate release and delayed neuronal cell death induced by transient ischemia in rats?]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1 Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Cell Death; Corpus Striatum; Dihydroxyphenylalanine; Glutamic Acid; Hippocampus; Hydrazines; Ischemic Attack, Transient; Levodopa; Male; Rats; Rats, Wistar	1998
Dietary salt intake alters cardiovascular responses evoked from the rostral ventrolateral medulla. The American journal of physiology, 1999, Volume: 276, Issue:6 Topics: Adrenergic alpha-Agonists; Afferent Pathways; Animals; Blood Pressure; Carbachol; Cardiovascular Physiological Phenomena; Diet, Sodium-Restricted; Dose-Response Relationship, Drug; Electric Stimulation; Glutamic Acid; Levodopa; Male; Medulla Oblongata; Microinjections; Muscarinic Agonists; Phenylephrine; Rats; Rats, Sprague-Dawley; Sciatic Nerve	1999
L-DOPA cyclohexyl ester is a novel potent and relatively stable competitive antagonist against L-DOPA among several L-DOPA ester compounds. Japanese journal of pharmacology, 2000, Volume: 82, Issue:1 Topics: Animals; Binding, Competitive; Blood Pressure; Glutamic Acid; Heart Rate; Levodopa; Male; Microdialysis; Microinjections; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Rats, Wistar	2000
Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells. European journal of pharmacology, 2000, Jul-21, Volume: 400, Issue:2-3 Topics: Aminopyridines; Analgesics; Animals; Antidepressive Agents; Carbamates; Cell Death; Clorgyline; Culture Media; Cystine; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; PC12 Cells; Phenylenediamines; Rats; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate	2000
Endogenously released DOPA is a causal factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rat striata. Journal of neurochemistry, 2001, Volume: 76, Issue:3 Topics: Animals; Cell Death; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Enzyme Inhibitors; Glutamic Acid; Hydrazines; Ischemic Attack, Transient; Levodopa; Male; Neurons; Rats; Rats, Wistar; Time Factors	2001
DOPA cyclohexyl ester, a competitive DOPA antagonist, protects glutamate release and resultant delayed neuron death by transient ischemia in hippocampus CA1 of conscious rats. Neuroscience letters, 2001, Feb-23, Volume: 299, Issue:3 Topics: Animals; Brain Ischemia; Cell Death; Dihydroxyphenylalanine; Glutamic Acid; Hippocampus; Levodopa; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Reperfusion Injury	2001
MK801 suppresses the L-DOPA-induced increase of glutamate in striatum of hemi-Parkinson rats. Brain research, 2002, Feb-01, Volume: 926, Issue:1-2 Topics: Animals; Antiparkinson Agents; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Male; Microdialysis; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Sympatholytics; Synaptic Transmission	2002
The role of glutamatergic transmission in the pathogenesis of levodopa-induced dyskinesias. Potential therapeutic approaches. Neurologia i neurochirurgia polska, 2001, Volume: 35 Suppl 3 Topics: Anticonvulsants; Antiparkinson Agents; Dopamine Agents; Dyskinesia, Drug-Induced; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Levodopa; Parkinson Disease; Riluzole	2001
Restorative effects of glutamate antagonists in experimental parkinsonism. Amino acids, 2002, Volume: 23, Issue:1-3 Topics: Animals; Anticonvulsants; Antiparkinson Agents; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Parkinsonian Disorders; Receptors, N-Methyl-D-Aspartate	2002
Plasticity of glutamatergic control of striatal acetylcholine release in experimental parkinsonism: opposite changes at group-II metabotropic and NMDA receptors. Journal of neurochemistry, 2003, Volume: 84, Issue:4 Topics: Acetylcholine; Animals; Antiparkinson Agents; Benserazide; Corpus Striatum; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Male; N-Methylaspartate; Neuronal Plasticity; Parkinsonian Disorders; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptosomes	2003
DOPA cyclohexyl ester potently inhibits aglycemia-induced release of glutamate in rat striatal slices. Neuroscience research, 2003, Volume: 45, Issue:3 Topics: Animals; Corpus Striatum; Dihydroxyphenylalanine; Glucose; Glutamic Acid; In Vitro Techniques; Levodopa; Male; Neuroprotective Agents; Rats; Rats, Wistar	2003
Modulation of the ability of clozapine to facilitate NMDA- and electrically evoked responses in pyramidal cells of the rat medial prefrontal cortex by dopamine: pharmacological evidence. The European journal of neuroscience, 2003, Volume: 17, Issue:6 Topics: 5-Hydroxytryptophan; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Benzazepines; Clozapine; Dopamine; Dopamine Agents; Dopamine Antagonists; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Levodopa; Male; N-Methylaspartate; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reserpine; Synaptic Transmission; Tyrosine 3-Monooxygenase	2003
Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. Journal of neurochemistry, 2003, Volume: 85, Issue:4 Topics: Amidohydrolases; Animals; Antiparkinson Agents; Arachidonic Acids; Binding, Competitive; Cannabinoid Receptor Modulators; Cerebellum; Corpus Striatum; Cyclohexanols; Disease Models, Animal; Endocannabinoids; Excitatory Postsynaptic Potentials; Fatty Acids, Unsaturated; Glutamic Acid; Glycerides; In Vitro Techniques; Levodopa; Oxidopamine; Parkinsonian Disorders; Patch-Clamp Techniques; Phospholipase D; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug	2003
[On the inhibition of L-glutamic acid and L-DOPA decarboxylase by D-cycloserine and other isoxazolidones]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1962, Volume: 243 Topics: Azoles; Carboxy-Lyases; Cycloserine; Glutamic Acid; Levodopa; Lyases	1962
Effect of a selective glutamate antagonist on L-dopa-induced dyskinesias in drug-naive parkinsonian monkeys. Neurobiology of disease, 2004, Volume: 15, Issue:2 Topics: Animals; Benzoxazoles; Corpus Striatum; Disease Models, Animal; Drug Interactions; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Levodopa; Macaca fascicularis; Parkinson Disease; Piperidines; Receptors, N-Methyl-D-Aspartate; Treatment Outcome	2004
L-DOPA-induced modulation of GABA and glutamate release in substantia nigra pars reticulata in a rodent model of Parkinson's disease. Synapse (New York, N.Y.), 2004, Volume: 52, Issue:2 Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Substantia Nigra	2004
Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism. Brain : a journal of neurology, 2004, Volume: 127, Issue:Pt 7 Topics: Animals; Antiparkinson Agents; Basal Ganglia; Dopamine Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Male; Models, Animal; Oxidopamine; Parkinson Disease; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D2; Synaptic Transmission	2004
Molecular chaperones affect GTP cyclohydrolase I mutations in dopa-responsive dystonia. Annals of neurology, 2004, Volume: 55, Issue:6 Topics: Animals; Animals, Newborn; Benzoquinones; Blotting, Northern; Blotting, Western; Cell Line; Cricetinae; DNA Mutational Analysis; Dystonia; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Glutamic Acid; Glycine; GTP Cyclohydrolase; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Levodopa; Molecular Chaperones; Mutation; Proteins; Quinones; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection	2004
Chronic L-DOPA treatment increases extracellular glutamate levels and GLT1 expression in the basal ganglia in a rat model of Parkinson's disease. The European journal of neuroscience, 2004, Volume: 20, Issue:5 Topics: Animals; Basal Ganglia; Drug Administration Schedule; Excitatory Amino Acid Transporter 2; Extracellular Fluid; Gene Expression Regulation; Glutamic Acid; Levodopa; Male; Parkinson Disease; Rats; Rats, Wistar	2004
Dopamine modulates release from corticostriatal terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Oct-27, Volume: 24, Issue:43 Topics: Animals; Corpus Striatum; Dopamine; Dopamine Agents; Exocytosis; Fluorescent Dyes; Glutamic Acid; Levodopa; Mice; Mice, Knockout; Microdialysis; Motor Cortex; Neural Pathways; Presynaptic Terminals; Pyridinium Compounds; Quaternary Ammonium Compounds; Quinpirole; Receptors, Dopamine D2; Reserpine; Tyrosine 3-Monooxygenase	2004
Cerebral glutamate metabolism in Parkinson's disease: an in vivo dynamic (13)C NMS study in the rat. Experimental neurology, 2005, Volume: 191, Issue:2 Topics: Animals; Antiparkinson Agents; Basal Ganglia; Carbon Isotopes; Disease Models, Animal; Dopamine; Glutamic Acid; Glutaminase; Glutamine; Infusions, Intravenous; Levodopa; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Sodium Acetate	2005
Subthalamic nucleus lesion reverses motor abnormalities and striatal glutamatergic overactivity in experimental parkinsonism. Neuroscience, 2005, Volume: 133, Issue:3 Topics: Animals; Antiparkinson Agents; Corpus Striatum; Denervation; Glutamic Acid; Levodopa; Male; Movement Disorders; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Subthalamic Nucleus; Sympatholytics; Synaptic Transmission	2005
Acute NMDA receptor antagonism induces biphasic striatal utilization of L-[beta-11C]DOPA: PET studies in the conscious monkey brain. Synapse (New York, N.Y.), 2005, Volume: 57, Issue:2 Topics: Animals; Binding, Competitive; Carbon Radioisotopes; Cocaine; Consciousness; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Macaca mulatta; Male; Neural Pathways; Positron-Emission Tomography; Presynaptic Terminals; Raclopride; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2005
l-dopa-induced reversal in striatal glutamate following partial depletion of nigrostriatal dopamine with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience, 2005, Volume: 136, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Immunohistochemistry; Levodopa; Male; Mice; Mice, Inbred C57BL; Microdialysis; Microscopy, Immunoelectron; Substantia Nigra; Tyrosine 3-Monooxygenase	2005
The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Feb-07, Volume: 27, Issue:6 Topics: Animals; Antiparkinson Agents; Benzimidazoles; Bicuculline; Drug Synergism; Drug Therapy, Combination; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Injections; Levodopa; Male; Microdialysis; Motor Activity; Neural Pathways; Nociceptin Receptor; Oxidopamine; Parkinsonian Disorders; Perfusion; Piperidines; Postural Balance; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sodium Channel Blockers; Stereotaxic Techniques; Substantia Nigra; Tetrodotoxin; Thalamus	2007
Glutamate measurement in Parkinson's disease using MRS at 3 T field strength. NMR in biomedicine, 2007, Volume: 20, Issue:8 Topics: Antiparkinson Agents; Aspartic Acid; Corpus Striatum; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Levodopa; Magnetic Resonance Spectroscopy; Parkinson Disease; Reference Values	2007
Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease. Journal of neurochemistry, 2007, Volume: 101, Issue:2 Topics: Animals; Antiparkinson Agents; Brain; Disease Models, Animal; Drug Interactions; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Microdialysis; Neural Inhibition; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Substantia Nigra; Synaptic Transmission	2007
Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats. Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:12 Topics: Animals; Antiparkinson Agents; Anxiety Disorders; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Glutamic Acid; Learning Disabilities; Levodopa; Male; Maze Learning; Memory Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Transmission; Thiazoles	2008
The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA. Journal of neurochemistry, 2008, Volume: 107, Issue:6 Topics: Animals; Antiparkinson Agents; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Functional Laterality; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Narcotic Antagonists; Neural Pathways; Nociceptin Receptor; Oxidopamine; Parkinsonian Disorders; Psychomotor Performance; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Substantia Nigra; Thalamus; Time Factors	2008
Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:1 Topics: Animals; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Levodopa; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission	2009
Metabotropic glutamate receptor type 5 in levodopa-induced motor complications. Neurobiology of aging, 2011, Volume: 32, Issue:7 Topics: Aged; Aged, 80 and over; Animals; Antiparkinson Agents; Cohort Studies; Corpus Striatum; Dyskinesia, Drug-Induced; Female; Glutamic Acid; Humans; Levodopa; Macaca fascicularis; Parkinsonian Disorders; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Up-Regulation	2011
Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proceedings of the National Academy of Sciences of the United States of America, 2009, Dec-29, Volume: 106, Issue:52 Topics: Acetylcholine; Animals; Arousal; Auditory Pathways; Auditory Perception; Basic Helix-Loop-Helix Transcription Factors; Corticotropin-Releasing Hormone; Female; Gene Expression Regulation, Developmental; Glutamic Acid; Levodopa; Mice; Mice, Transgenic; Nerve Net; Neural Pathways; Neurons; Nitric Oxide; Pregnancy; Proprioception; Rhombencephalon; Somatostatin	2009
Metabolic changes detected in vivo by 1H MRS in the MPTP-intoxicated mouse. NMR in biomedicine, 2010, Volume: 23, Issue:6 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Dopamine; Dopamine Agents; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Levodopa; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Neurotoxins; Protons	2010
Reduced DNA oxidation in aged prostaglandin H synthase-1 knockout mice. Free radical biology & medicine, 2011, Feb-15, Volume: 50, Issue:4 Topics: 8-Hydroxy-2'-Deoxyguanosine; Age Factors; Animals; Brain Chemistry; Cyclooxygenase 1; Deoxyguanosine; DNA Damage; Dopamine; Epinephrine; Female; Free Radicals; Gene Deletion; Glutamic Acid; Levodopa; Male; Mice; Mice, Knockout; Norepinephrine; Oxidants; Oxidation-Reduction; Reactive Oxygen Species	2011
Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rats. Experimental neurology, 2011, Volume: 229, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antiparkinson Agents; Benserazide; Benzazepines; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine Agonists; Dyskinesia, Drug-Induced; Glutamic Acid; Levodopa; Male; Microdialysis; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists	2011
Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats. Neurotoxicity research, 2012, Volume: 21, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Benserazide; Caffeine; Dopamine; Glutamic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles	2012
In vivo evidence for a differential contribution of striatal and nigral D1 and D2 receptors to L-DOPA induced dyskinesia and the accompanying surge of nigral amino acid levels. Neurobiology of disease, 2012, Volume: 45, Issue:1 Topics: Animals; Benzazepines; Corpus Striatum; Dopamine Antagonists; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Male; Microdialysis; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Substantia Nigra	2012
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Brain; Calcium Signaling; Catalepsy; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Glutamic Acid; Haloperidol; HEK293 Cells; Humans; Levodopa; Male; Monoamine Oxidase; Motor Neuron Disease; Oxidopamine; Parkinson Disease; Picolinic Acids; Protein Binding; Psychomotor Performance; Pyrimidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reaction Time; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate; Substantia Nigra; Thallium; Transfection; Triazoles; Tyrosine 3-Monooxygenase	2012
A liquid phase based C. elegans behavioral analysis system identifies motor activity loss in a nematode Parkinson's disease model. Journal of neuroscience methods, 2012, Mar-15, Volume: 204, Issue:2 Topics: Animals; Animals, Genetically Modified; Antiparkinson Agents; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Electronic Data Processing; Glutamic Acid; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Levodopa; Motor Activity; Mutation; Parkinson Disease; Protein Serine-Threonine Kinases; Serine; Software	2012
The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2. Neurotoxicity research, 2012, Volume: 22, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Oxidative Stress; Rats; Rats, Wistar; Reserpine; Triazines; Triazoles; Vesicular Monoamine Transport Proteins	2012
Striatal interaction among dopamine, glutamate and ascorbate. Neuropharmacology, 2012, Volume: 63, Issue:8 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antioxidants; Ascorbic Acid; Basal Ganglia Diseases; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Dopamine Antagonists; Electrochemistry; Fluorometry; Glutamic Acid; Haloperidol; Levodopa; Male; Microdialysis; Neostriatum; Rats; Rats, Sprague-Dawley	2012
Dissociating the cognitive effects of levodopa versus dopamine agonists in a neurocomputational model of learning in Parkinson's disease. Neuro-degenerative diseases, 2013, Volume: 11, Issue:2 Topics: Animals; Basal Ganglia; Cognition; Dopamine Agonists; Dopaminergic Neurons; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Learning; Levodopa; Memory; Models, Neurological; Parkinson Disease; Prefrontal Cortex; Receptors, Dopamine D1; Receptors, Dopamine D2	2013
Nociceptin/orphanin FQ receptor agonists attenuate L-DOPA-induced dyskinesias. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Nov-14, Volume: 32, Issue:46 Topics: Animals; Anti-Dyskinesia Agents; Antiparkinson Agents; Autoradiography; Behavior, Animal; Dyskinesia, Drug-Induced; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Macaca; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Microinjections; Nociceptin; Opioid Peptides; Oxidopamine; Postural Balance; Rats; Rats, Sprague-Dawley; Rats, Wistar	2012
Striatal glutamate release in L-DOPA-induced dyskinetic animals. PloS one, 2013, Volume: 8, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antiparkinson Agents; Benserazide; Corpus Striatum; Dopamine; Drug Combinations; Dyskinesia, Drug-Induced; Female; Glutamic Acid; Injections, Intraventricular; Levodopa; Potassium; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Signal Transduction	2013
Striatal glutamate induces retrograde excitotoxicity and neuronal degeneration of intralaminar thalamic nuclei: their potential relevance for Parkinson's disease. The European journal of neuroscience, 2013, Volume: 38, Issue:1 Topics: Action Potentials; Animals; Cell Death; Corpus Striatum; Dopamine; Dopamine Agents; Glutamic Acid; Intralaminar Thalamic Nuclei; Levodopa; Male; Microglia; Neurons; Parkinson Disease; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Vesicular Glutamate Transport Protein 2	2013
GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal involuntary movements in dyskinetic rats. ACS chemical neuroscience, 2013, May-15, Volume: 4, Issue:5 Topics: Animals; Corpus Striatum; Dopamine; Dopamine Agents; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra	2013
Combined treatment with acupuncture reduces effective dose and alleviates adverse effect of L-dopa by normalizing Parkinson's disease-induced neurochemical imbalance. Brain research, 2014, Jan-28, Volume: 1544 Topics: Acupuncture Therapy; Animals; Antiparkinson Agents; Brain Chemistry; Combined Modality Therapy; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Male; Mice; Mice, Inbred C57BL; Movement; Oxidopamine; Parkinson Disease, Secondary; Proto-Oncogene Proteins c-fos; Substantia Nigra	2014
Glutamate spillover drives endocannabinoid production and inhibits GABAergic transmission in the Substantia Nigra pars compacta. Neuropharmacology, 2014, Volume: 79 Topics: Animals; Arachidonic Acids; Benzofurans; Calcium; Cannabinoid Receptor Antagonists; Central Nervous System Agents; Dopamine; Dopamine Agents; Dopaminergic Neurons; Endocannabinoids; Glutamic Acid; Guanosine Diphosphate; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Levodopa; Neurons; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Substantia Nigra; Synaptic Transmission; Thionucleotides	2014
NMDA receptor antagonism potentiates the L-DOPA-induced extracellular dopamine release in the subthalamic nucleus of hemi-parkinson rats. Neuropharmacology, 2014, Volume: 85 Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Extracellular Space; Functional Laterality; Glutamic Acid; Levodopa; Male; Microdialysis; Oxidopamine; Parkinsonian Disorders; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Subthalamic Nucleus	2014
Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity. Movement disorders : official journal of the Movement Disorder Society, 2015, Volume: 30, Issue:13 Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dopamine; Dyskinesia, Drug-Induced; Functional Laterality; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Levodopa; Male; MAP Kinase Signaling System; Motor Activity; Oxidopamine; Parkinson Disease; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Time Factors	2015
Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, L-DOPA Responsivity, and Glutamatergic Neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Oct-14, Volume: 35, Issue:41 Topics: Adrenergic Agents; Akathisia, Drug-Induced; Animals; Antiparkinson Agents; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Plasma Membrane Transport Proteins; Glutamic Acid; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligodeoxyribonucleotides, Antisense; Oxidopamine; Parkinsonian Disorders; Radiopharmaceuticals; Receptors, G-Protein-Coupled; Stereotyped Behavior; Synaptic Transmission; Time Factors; Tyrosine 3-Monooxygenase	2015
Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia. Neurobiology of disease, 2016, Volume: 85 Topics: Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Glutamic Acid; GTP-Binding Proteins; Levodopa; Male; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Multiprotein Complexes; Neurons; Neuroprotective Agents; Sirolimus; Substantia Nigra; TOR Serine-Threonine Kinases	2016
M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia. Neuron, 2015, Nov-18, Volume: 88, Issue:4 Topics: Allosteric Regulation; Animals; Cerebral Cortex; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Glutamic Acid; Levodopa; Long-Term Potentiation; Long-Term Synaptic Depression; Macaca mulatta; Mice; Mice, Transgenic; Neostriatum; Neuronal Plasticity; Neurons; Parkinsonian Disorders; Receptor, Muscarinic M4; RGS Proteins; Signal Transduction	2015
The novel 5-HT1A receptor agonist, NLX-112 reduces l-DOPA-induced abnormal involuntary movements in rat: A chronic administration study with microdialysis measurements. Neuropharmacology, 2016, Volume: 105 Topics: Animals; Anti-Dyskinesia Agents; Corpus Striatum; Cross-Over Studies; Dopamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Male; Microdialysis; Oxidopamine; Parkinsonian Disorders; Piperidines; Pyridines; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists	2016
L-DOPA Reverses the Increased Free Amino Acids Tissue Levels Induced by Dopamine Depletion and Rises GABA and Tyrosine in the Striatum. Neurotoxicity research, 2016, Volume: 30, Issue:1 Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Forelimb; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Levodopa; Mice; Oxidopamine; Rotarod Performance Test; Taurine; Tyrosine	2016
The Role of Primary Motor Cortex (M1) Glutamate and GABA Signaling in l-DOPA-Induced Dyskinesia in Parkinsonian Rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 09-21, Volume: 36, Issue:38 Topics: Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Male; Motor Cortex; Movement; Oxidopamine; Parkinsonian Disorders; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Signal Transduction; Sympatholytics; Tardive Dyskinesia	2016
Intrastriatal injection of ionomycin profoundly changes motor response to l-DOPA and its underlying molecular mechanisms. Neuroscience, 2017, 01-06, Volume: 340 Topics: Animals; Antiparkinson Agents; Calcineurin; Calcium Ionophores; Corpus Striatum; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dyskinesia, Drug-Induced; Glutamic Acid; Ionomycin; Levodopa; Male; MAP Kinase Signaling System; Parkinsonian Disorders; Phosphorylation; Proto-Oncogene Proteins c-fos; Random Allocation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	2017
Glutamatergic mechanisms in L-DOPA-induced dyskinesia and therapeutic implications. Journal of neural transmission (Vienna, Austria : 1996), 2018, Volume: 125, Issue:8 Topics: Animals; Antiparkinson Agents; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Levodopa; Neurons; Receptors, Glutamate	2018
Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia. Neuropharmacology, 2020, 01-01, Volume: 162 Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Cholinesterase Inhibitors; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; GABAergic Neurons; Glutamic Acid; Levodopa; Locomotion; Male; Medial Forebrain Bundle; Mice; Mice, Knockout; Movement; Neuronal Plasticity; Oxidopamine; Parkinsonian Disorders; Receptors, G-Protein-Coupled; RNA, Messenger; Serotonin; Tacrine; Tremor	2020
Effects of safinamide on the glutamatergic striatal network in experimental Parkinson's disease. Neuropharmacology, 2020, 06-15, Volume: 170 Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Glutamic Acid; Levodopa; Male; Nerve Net; Organ Culture Techniques; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar	2020
Acute and Chronic Dopaminergic Depletion Differently Affect Motor Thalamic Function. International journal of molecular sciences, 2020, Apr-15, Volume: 21, Issue:8 Topics: Adrenergic Agents; Animals; Basal Ganglia; Cerebral Cortex; Deep Brain Stimulation; Dopamine; Dopamine Agents; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Levodopa; Male; Medial Forebrain Bundle; Microdialysis; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Thalamus	2020
Striatal and nigral muscarinic type 1 and type 4 receptors modulate levodopa-induced dyskinesia and striato-nigral pathway activation in 6-hydroxydopamine hemilesioned rats. Neurobiology of disease, 2020, Volume: 144 Topics: Allosteric Regulation; Animals; Dopamine Agents; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Microdialysis; Muscarinic Antagonists; Neostriatum; Neural Pathways; Oxidopamine; Parkinsonian Disorders; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Substantia Nigra; Sympatholytics	2020
Accelerated habitual learning resulting from L-dopa exposure in rats is prevented by N-acetylcysteine. Pharmacology, biochemistry, and behavior, 2020, Volume: 198 Topics: Acetylcysteine; Animals; Antioxidants; Behavior, Addictive; Behavior, Animal; Conditioning, Operant; Dopamine; Dopamine Agents; Glutamic Acid; Habits; Levodopa; Male; Motor Activity; Parkinson Disease; Rats; Rats, Long-Evans	2020
Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating. The Journal of clinical investigation, 2020, 12-01, Volume: 130, Issue:12 Topics: Acetylcholine; Adult; Animals; Corpus Striatum; Donepezil; Feeding and Eating Disorders; Feeding Behavior; Female; Glutamic Acid; Humans; Interneurons; Levodopa; Male; Mice; Mice, Knockout; Middle Aged; Vesicular Acetylcholine Transport Proteins	2020
Chronic H Psychopharmacology, 2023, Volume: 240, Issue:6 Topics: Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Male; Oxidopamine; Rats; RNA, Messenger	2023