levodopa has been researched along with dizocilpine maleate in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.89) | 18.7374 |
| 1990's | 29 (54.72) | 18.2507 |
| 2000's | 19 (35.85) | 29.6817 |
| 2010's | 4 (7.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Di Chiara, G; Fenu, S; Morelli, M | 1 |
| Boyce, S; Iversen, SD; Marsden, CD; Rupniak, NM; Steventon, MJ | 1 |
| Agid, Y; Holemans, S; Javoy, F; Laterre, EC; Maloteaux, JM | 1 |
| Labruyere, J; Olney, JW; Price, MT; Stewart, GR; Wang, GJ; Zorumski, CF | 1 |
| Di Chiara, G; Morelli, M | 1 |
| Dimpfel, W; Spüler, M | 1 |
| Klockgether, T; Turski, L | 1 |
| Boyce, S; Crossman, AR; Luquin, MR; Peggs, D; Sambrook, MA | 1 |
| Boldry, RC; Chase, TN; Engber, TM; Papa, SM | 1 |
| Carey, RJ; Huston, JP; Pinheiro-Carrera, M; Tomaz, C | 1 |
| Archer, T; Fredriksson, A; Gentsch, C | 1 |
| Carta, A; Cozzolino, A; Di Chiara, G; Fenu, S; Morelli, M; Pinna, A | 1 |
| Kaur, S; Starr, BS; Starr, MS | 1 |
| Boldry, RC; Chase, TN; Engber, TM | 1 |
| Schmidt, WJ; Zadow, B | 1 |
| de Groat, WC; Roppolo, JR; Yoshiyama, M | 1 |
| Anderson, JJ; Boldry, RC; Chase, TN; Engber, TM; Kuo, S; Papa, SM | 1 |
| Breese, GR; Criswell, HE; Johnson, KB; Mueller, RA | 1 |
| Eller, RV; Gash, DM; Greenamyre, JT; Kurlan, R; Ovadia, A; Zhang, Z | 1 |
| Boldry, RC; Chase, TN; Kask, AM; Papa, SM | 1 |
| Biggs, C; Fowler, L; Starr, M; Whitton, P | 1 |
| Hashiguchi, H; Ishida, Y; Kuwahara, I; Mitsuyama, Y; Nishimori, T; Todaka, K | 1 |
| Boldry, RC; Chase, TN; Engber, TM; Kask, AM; Papa, SM | 1 |
| Bonastre, M; Chase, TN; Engber, TM; Marin, C; Papa, S; Tolosa, E | 1 |
| Itakura, T; Nakai, K; Nakao, N | 1 |
| Barone, P; DiChiara, G; Morelli, M; Pellecchia, MT; Vallone, D; Verde, P | 1 |
| Goshima, Y; Kawashima, K; Misu, Y; Miyamae, T; Ohshima, E; Shibata, T; Shimizu, M; Suzuki, F | 1 |
| McEwen, ML; Stehouwer, DJ; Van Hartesveldt, C | 1 |
| Agid, Y; Hirsch, EC; Jimenez, A; Marin, C; Raisman-Vozari, R; Ruberg, M; Tolosa, E; Vila, M | 1 |
| Archer, T; Chase, T; Fredriksson, A; Palomo, T | 1 |
| Bordet, R; Ridray, S; Schwartz, JC; Sokoloff, P | 1 |
| Di Monte, DA; He, L; Langston, JW; Quik, M | 1 |
| Bergmann, R; Gasparini, F; Kuhn, R; Spooren, WP | 1 |
| Ebinger, G; Jonkers, N; Michotte, Y; Sarre, S | 2 |
| Archer, T; Danysz, W; Fredriksson, A; Quack, G | 1 |
| Ferger, B; Schmidt, N; Schulz, JB; Teismann, P; Xia, XG | 1 |
| Groenewegen, HJ; Van De Witte, SV; Voorn, P | 1 |
| Bacci, JJ; Kerkerian-Le Goff, L; Salin, P | 1 |
| Bonastre, M; Hirsch, EC; Marin, C; Périer, C; Tolosa, E | 1 |
| Archer, T; Fredriksson, A | 1 |
| Nakagawa, M; Nishizawa, Y; Ogura, H; Ohgoh, M | 1 |
| Harris, RC; Kelsey, JE; Kleckner, NW; Mague, SD; Matthews, RT; Pijanowski, RS | 1 |
| Brotchie, JM; Fox, SH; Gomez-Ramirez, J; Johnston, TH; Lee, J | 1 |
| Amalric, M; Baunez, C; Breysse, N; Turle-Lorenzo, N | 1 |
| Fukumoto, D; Harada, N; Kakiuchi, T; Miyasato, K; Nishiyama, S; Tsukada, H | 1 |
| Bibbiani, F; Chase, TN; Collins, MA; Kielaite, A; Oh, JD; Smith, C | 1 |
| Bishop, C; Dupre, KB; Eskow, KL; Klioueva, A; Lormand, L; Negron, GE; Park, JY; Steiniger, A | 1 |
| Anderson, AM; Johnson, SW; Lewis, JR; Meshul, CK; Paquette, MA; Paul Berger, S | 1 |
| Ampe, B; Aourz, N; Bentea, E; De Deurwaerdère, P; El Arfani, A; Massie, A; Michotte, Y; Sarre, S; Smolders, I; Van Eeckhaut, A | 1 |
| Chen, SY; Shao, B; Wang, XS; Xie, CL; Zhang, XR; Zhang, ZR | 1 |
| Bartlett, MJ; Falk, T; Flores, AJ; Heien, ML; Parent, KL; Polt, R; Porreca, F; Root, BK; Sherman, SJ | 1 |
53 other study(ies) available for levodopa and dizocilpine maleate
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Blockade of N-methyl-D-aspartate receptors potentiates dopaminergic responses in the 6-OHDA model of Parkinson: differential role of D-1 and D-2 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Caudate Nucleus; Dizocilpine Maleate; Dopamine; Drug Synergism; Levodopa; Male; Oxidopamine; Parkinson Disease, Secondary; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate | 1992 |
Dystonia induced by combined treatment with L-dopa and MK-801 in parkinsonian monkeys.
Topics: Animals; Dizocilpine Maleate; Drug Combinations; Drug Synergism; Dystonia; Levodopa; Male; Motor Activity; Parkinson Disease, Secondary; Reference Values; Saimiri | 1992 |
[3H]MK-801 binding to NMDA glutamatergic receptors in Parkinson's disease and progressive supranuclear palsy.
Topics: Aged; Brain; Dizocilpine Maleate; Humans; Kinetics; Levodopa; Organ Specificity; Parkinson Disease; Receptors, N-Methyl-D-Aspartate; Reference Values; Supranuclear Palsy, Progressive | 1991 |
Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseases.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chick Embryo; Dibenzocycloheptenes; Dihydroxyphenylalanine; Dizocilpine Maleate; Hippocampus; Huntington Disease; Levodopa; Neurons; Parkinson Disease; Quinoxalines; Receptors, Neurotransmitter; Retina | 1990 |
MK-801 potentiates dopaminergic D1 but reduces D2 responses in the 6-hydroxydopamine model of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benserazide; Dizocilpine Maleate; Dopamine Agents; Ergolines; Hydroxydopamines; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease, Secondary; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Stereotyped Behavior | 1990 |
Dizocilpine (MK-801), ketamine and phencyclidine: low doses affect brain field potentials in the freely moving rat in the same way as activation of dopaminergic transmission.
Topics: Amphetamine; Animals; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Electroencephalography; Ketamine; Levodopa; Male; Membrane Potentials; Mice; Phencyclidine; Rats; Rats, Inbred F344; Synaptic Transmission; Time Factors | 1990 |
NMDA antagonists potentiate antiparkinsonian actions of L-dopa in monoamine-depleted rats.
Topics: Animals; Dizocilpine Maleate; Drug Synergism; Electromyography; Levodopa; Male; Methyltyrosines; Motor Activity; Muscle Rigidity; N-Methylaspartate; Parkinson Disease; Piperazines; Rats; Rats, Inbred Strains; Reserpine | 1990 |
Effect of the NMDA antagonist MK-801 on MPTP-induced parkinsonism in the monkey.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Injections, Intramuscular; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; N-Methylaspartate; Parkinson Disease, Secondary | 1989 |
NMDA receptor blockade reverses motor response alterations induced by levodopa.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dizocilpine Maleate; Levodopa; Male; Motor Activity; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rotation; Stereotyped Behavior | 1994 |
NMDA antagonist effects on the development of L-dopa behavioral sensitization in rats.
Topics: Animals; Dizocilpine Maleate; Dominance, Cerebral; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Motor Activity; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior; Substance Withdrawal Syndrome; Synaptic Transmission; Tegmentum Mesencephali | 1995 |
Synergistic interactions between NMDA-antagonists and L-dopa on activity in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1994 |
Differential effect of MK 801 and scopolamine on c-fos expression induced by L-dopa in the striatum of 6-hydroxydopamine lesioned rats.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gene Expression; Genes, fos; Immunohistochemistry; Levodopa; Male; Neostriatum; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Scopolamine; Stereotyped Behavior | 1994 |
Role of D1 receptor mechanisms in the potentiation of motor responses to L-dopa and apomorphine by MK 801 in the reserpine-treated mouse.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Levodopa; Male; Mice; Motor Activity; Receptors, Dopamine; Reserpine | 1994 |
Influence of previous exposure to levodopa on the interaction between dizocilpine and dopamine D1 and D2 agonists in rats with 6-hydroxydopamine-induced lesions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Brain Diseases; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Levodopa; Male; Motor Activity; N-Methylaspartate; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1993 |
The AMPA antagonists NBQX and GYKI 52466 do not counteract neuroleptic-induced catalepsy.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Catalepsy; Dizocilpine Maleate; Drug Interactions; Ergolines; Haloperidol; Levodopa; Male; Pilot Projects; Quinoxalines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1994 |
Interactions between glutamatergic and monoaminergic systems controlling the micturition reflex in the urethane-anesthetized rat.
Topics: Anesthesia; Animals; Apomorphine; Biogenic Monoamines; Dizocilpine Maleate; Female; Fenclonine; Glutamates; Glutamic Acid; Levodopa; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Reflex; Reserpine; Urethane; Urination | 1994 |
Excitatory amino acid receptor antagonists modify regional cerebral metabolic responses to levodopa in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Levodopa; Male; Motor Activity; Organ Specificity; Oxidopamine; Quinoxalines; Rats; Rats, Sprague-Dawley | 1994 |
Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats.
Topics: alpha-Methyltyrosine; Animals; Animals, Newborn; Behavior, Animal; Brain; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Gene Expression; Genes, fos; Levodopa; Male; Methyltyrosines; N-Methylaspartate; Pipecolic Acids; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Serotonin; Tyrosine 3-Monooxygenase | 1993 |
Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetamides; Analysis of Variance; Animals; Anticonvulsants; Antiparkinson Agents; Brain; Carbidopa; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Levodopa; Macaca mulatta; Male; Motor Activity; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors | 1994 |
MK-801 reverses effects of chronic levodopa on D1 and D2 dopamine agonist-induced rotational behavior.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Dizocilpine Maleate; Dopamine Agents; Dopamine Agonists; Ergolines; Excitatory Amino Acid Antagonists; Levodopa; Male; Oxidopamine; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation; Stereotyped Behavior; Sympatholytics | 1995 |
Effects of glutamate antagonists on nigral dopamine release in the reserpine-treated rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Methyltyrosine; Animals; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Methyltyrosines; Raclopride; Rats; Reserpine; Salicylamides; Substantia Nigra | 1996 |
Dopaminergic transplants suppress L-DOPA-induced Fos expression in the dopamine-depleted striatum in a rat model of Parkinson's disease.
Topics: Animals; Brain Tissue Transplantation; Caudate Nucleus; Corpus Striatum; Dizocilpine Maleate; Dopamine; Female; Fetal Tissue Transplantation; Levodopa; Mesencephalon; Methamphetamine; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 1996 |
Reversal of levodopa-induced motor fluctuations in experimental parkinsonism by NMDA receptor blockade.
Topics: Animals; Antiparkinson Agents; Apomorphine; Benserazide; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections; Injections, Intraventricular; Levodopa; Male; Movement; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rotation; Stereotyped Behavior; Substantia Nigra | 1995 |
MK-801 prevents levodopa-induced motor response alterations in parkinsonian rats.
Topics: Animals; Antiparkinson Agents; Benserazide; Dizocilpine Maleate; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease; Prosencephalon; Rats; Rats, Sprague-Dawley; Rotation | 1996 |
Metabolic inhibition enhances selective toxicity of L-DOPA toward mesencephalic dopamine neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antioxidants; Cells, Cultured; Dizocilpine Maleate; Dopamine; Dopamine Agents; Drug Synergism; Excitatory Amino Acid Antagonists; Levodopa; Mesencephalon; NAD(P)H Dehydrogenase (Quinone); Neurons; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Uncoupling Agents | 1997 |
Behavioural sensitization in 6-hydroxydopamine-lesioned rats is related to compositional changes of the AP-1 transcription factor: evidence for induction of FosB- and JunD-related proteins.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benserazide; Cell Nucleus; Corpus Striatum; Denervation; Dizocilpine Maleate; Gene Expression Regulation; Levodopa; Male; Motor Activity; Neurons; Oxidopamine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior; Transcription Factor AP-1 | 1997 |
Some interactions of L-DOPA and its related compounds with glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Kainic Acid; Levodopa; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Xenopus laevis | 1999 |
The NMDA antagonist, MK-801, alters L-DOPA-induced air-stepping in neonatal rats.
Topics: Animals; Animals, Newborn; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Levodopa; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Videotape Recording | 1999 |
Systemic administration of NMDA and AMPA receptor antagonists reverses the neurochemical changes induced by nigrostriatal denervation in basal ganglia.
Topics: Animals; Basal Ganglia; Corpus Striatum; Denervation; Dizocilpine Maleate; Dopamine; Electron Transport Complex IV; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Isoquinolines; Levodopa; Male; N-Methylaspartate; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Messenger; Substantia Nigra; Tetrazoles | 1999 |
Tolerance to a suprathreshold dose of L-Dopa in MPTP mice: effects of glutamate antagonists.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Antiparkinson Agents; Differential Threshold; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Sexual Behavior, Animal | 1999 |
Involvement of the direct striatonigral pathway in levodopa-induced sensitization in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Antiparkinson Agents; Benzazepines; Binding, Competitive; Corpus Striatum; Denervation; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Enkephalins; Excitatory Amino Acid Antagonists; Gene Expression; Levodopa; Male; Neural Pathways; Neurons; Opioid Peptides; Oxidopamine; Parkinson Disease, Secondary; Protein Precursors; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Substantia Nigra; Sympatholytics; Tachykinins; Tetrahydronaphthalenes; Tritium; Ventral Tegmental Area | 2000 |
Autoradiographic analysis of N-methyl-D-aspartate receptor binding in monkey brain: effects of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine and levodopa treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Brain Chemistry; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Iodine Radioisotopes; Levodopa; Parkinson Disease, Secondary; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Saimiri | 2000 |
Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats.
Topics: Animals; Apomorphine; Dextroamphetamine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Levodopa; Male; Motor Activity; Oxidopamine; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Rotation | 2000 |
MK801 influences L-DOPA-induced dopamine release in intact and hemi-parkinson rats.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Corpus Striatum; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Substantia Nigra | 2000 |
Co-administration of memantine and amantadine with sub/suprathreshold doses of L-Dopa restores motor behaviour of MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amantadine; Animals; Antiparkinson Agents; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Levodopa; Male; Memantine; Mice; Mice, Inbred C57BL; Motor Activity; Parkinsonian Disorders; Recovery of Function | 2001 |
Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Benzazepines; Brain Diseases; Carbidopa; Carrier Proteins; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine D2 Receptor Antagonists; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Malonates; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuropeptides; Oxidopamine; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Reserpine; Succinate Dehydrogenase; Sulpiride; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2001 |
MK-801 alters the effects of priming with L-DOPA on dopamine D1 receptor-induced changes in neuropeptide mRNA levels in the rat striatal output neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agents; Dopamine Agonists; Drug Interactions; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Excitatory Amino Acid Antagonists; Immunohistochemistry; Levodopa; Male; Motor Activity; Neostriatum; Neurons; Neuropeptides; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tachykinins; Tyrosine 3-Monooxygenase | 2002 |
MK801 suppresses the L-DOPA-induced increase of glutamate in striatum of hemi-Parkinson rats.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Male; Microdialysis; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Sympatholytics; Synaptic Transmission | 2002 |
Systemic administration of dizocilpine maleate (MK-801) or L-dopa reverses the increases in GAD65 and GAD67 mRNA expression in the globus pallidus in a rat hemiparkinsonian model.
Topics: Animals; Dizocilpine Maleate; Female; Globus Pallidus; Glutamate Decarboxylase; Injections, Subcutaneous; Isoenzymes; Levodopa; Parkinsonian Disorders; Rats; Rats, Wistar; RNA, Messenger | 2002 |
AMPA receptor antagonist LY293558 reverses preproenkephalin mRNA overexpression in the striatum of 6-OHDA-lesioned-rats treated with L-dopa.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Enkephalins; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Isoquinolines; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tetrazoles | 2002 |
Effect of postnatal iron administration on MPTP-induced behavioral deficits and neurotoxicity: behavioral enhancement by L-Dopa-MK-801 co-administration.
Topics: Animals; Behavior, Animal; Brain Chemistry; Critical Period, Psychological; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Habituation, Psychophysiologic; Iron; Iron Overload; Levodopa; Locomotion; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Time | 2003 |
Dopaminergic agonists and muscarinic antagonists improve lateralization in hemiparkinsonian rats in a novel exploratory Y-maze.
Topics: Animals; Antiparkinson Agents; Cholinergic Antagonists; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agonists; Functional Laterality; Levodopa; Male; Muscarinic Antagonists; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2004 |
NMDA receptor antagonists ameliorate the stepping deficits produced by unilateral medial forebrain bundle injections of 6-OHDA in rats.
Topics: Adrenergic Agents; Animals; Brain; Dizocilpine Maleate; Dopamine Agents; Drug Interactions; Gait; Levodopa; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Receptors, N-Methyl-D-Aspartate | 2004 |
A simple rodent assay for the in vivo identification of agents with potential to reduce levodopa-induced dyskinesia in Parkinson's disease.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amantadine; Animals; Anti-Dyskinesia Agents; Antiparkinson Agents; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Haloperidol; Idazoxan; Levodopa; Male; Motor Activity; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reserpine | 2005 |
Functional interaction between mGlu 5 and NMDA receptors in a rat model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Levodopa; Male; Parkinsonian Disorders; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2005 |
Nicotine modulates dopamine synthesis rate as determined by L-[beta-11C]DOPA: PET studies compared with [11C]raclopride binding in the conscious monkey brain.
Topics: Acetylcholine; Animals; Binding, Competitive; Brain; Carbon Radioisotopes; Cerebellum; Consciousness; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Levodopa; Macaca mulatta; Male; Neural Pathways; Nicotine; Positron-Emission Tomography; Presynaptic Terminals; Raclopride; Synaptic Transmission | 2005 |
Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD.
Topics: Amantadine; Animals; Antiparkinson Agents; Behavior, Animal; Benzazepines; Benzodiazepines; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Haplorhini; Levodopa; Male; Motor Activity; Parkinson Disease, Secondary; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Rotarod Performance Test; Time Factors | 2005 |
Effects of coincident 5-HT1A receptor stimulation and NMDA receptor antagonism on L-DOPA-induced dyskinesia and rotational behaviors in the hemi-parkinsonian rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Levodopa; Male; Medial Forebrain Bundle; Motor Activity; Motor Skills; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Receptor Agonists; Stereotyped Behavior | 2008 |
MK-801 inhibits L-DOPA-induced abnormal involuntary movements only at doses that worsen parkinsonism.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dizocilpine Maleate; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Levodopa; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotation; Time Factors | 2010 |
NMDA receptor antagonism potentiates the L-DOPA-induced extracellular dopamine release in the subthalamic nucleus of hemi-parkinson rats.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Extracellular Space; Functional Laterality; Glutamic Acid; Levodopa; Male; Microdialysis; Oxidopamine; Parkinsonian Disorders; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Subthalamic Nucleus | 2014 |
Modulation of CaMKIIa-GluN2B interaction in levodopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's rats.
Topics: Animals; Behavior, Animal; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Corpus Striatum; Dizocilpine Maleate; Dyskinesia, Drug-Induced; Levodopa; Male; Neurons; Oxidopamine; Parkinson Disease; Phosphorylation; Protein Binding; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sulfonamides | 2018 |
The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia.
Topics: Animals; Antiparkinson Agents; Benzazepines; Dizocilpine Maleate; Drug Synergism; Dyskinesia, Drug-Induced; Glycopeptides; Levodopa; Male; Oxidopamine; Parkinson Disease, Secondary; Quinpirole; Rats | 2018 |