levodopa has been researched along with dihydroxyphenylalanine in 281 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 127 (45.20) | 18.7374 |
| 1990's | 77 (27.40) | 18.2507 |
| 2000's | 47 (16.73) | 29.6817 |
| 2010's | 27 (9.61) | 24.3611 |
| 2020's | 3 (1.07) | 2.80 |
| Authors | Studies |
|---|---|
| Gazit, A; Gilon, C; Levitzki, A; Yaish, P | 1 |
| Sueishi, Y; Takemoto, T | 1 |
| Davidson, L; Hornykiewicz, O; Lloyd, KG | 1 |
| Bissette, G; Lipton, MA; Loosen, PT; Manberg, PJ; Nemeroff, CB; Prange, AJ; Wilson, IC | 1 |
| de Vries, JA; Fremouw-Ottevangers, DC; Muskiet, FA; van der Meulen, J; Wolthers, BG | 1 |
| Brown, RM; Brozoski, TJ; Goldman, PS; Rosvold, HE | 1 |
| Halbhübner, K; Herken, H; Kehr, W; Loos, D | 1 |
| Aminoff, MJ; Keenan, J; Kremer, M; Millar, JG; Wilcox, CS | 1 |
| Zarifian, E | 1 |
| Davidson, L; Gall, DG; Lloyd, KG; McClung, HJ; Price, K | 1 |
| Maître, L; Waldmeier, PC | 1 |
| Anisimov, VN; Dmitrievskaia, AIu; Gracheva, GM; Il'in, AP; Pozdeev, VK | 1 |
| Harik, SI | 1 |
| Aiello-Malmberg, P; Bartolini, A; Bartolini, R; Galli, A | 1 |
| Comi, R; Fahn, S; Prasad, AL; Snider, SR | 1 |
| Harrisson, F | 1 |
| Bednarczyk, B; Podolec, Z; Szczeklik, A; Vetulani, J | 1 |
| Green, JP; Mizoguchi, H; Orlowski, M; Wilk, S | 1 |
| Cremer, H; Neuhoff, V; Osborne, NN; Sontag, KH; Wand, P | 1 |
| Erina, EV; Kiseleva, ZM; Parfenova, EV; Shkhvatsabaia, IK | 1 |
| McDowell, FH; Miller, ST; Papavasiliou, PS; Rosal, V; Wang, YY | 1 |
| Davidson, DL; Mawdsley, C; Pullar, IA; Wilson, H; Yates, CM | 1 |
| Feuerstein, C; Gavend, M; Pellat, J; Perret, J; Serre, F; Tanche, M | 1 |
| Petelin, LS; Romenskaia, LKh; Vartanian, KZ | 1 |
| Jenner, PG; Jones, MK; Ramsay, ID | 1 |
| Mizoguchi, H; Orlowski, M; Wilk, S | 1 |
| Barkhatova, VP; Markova, ED | 1 |
| Carlsson, A | 1 |
| Bartholini, G; Pletscher, A | 1 |
| Ernst, AM | 1 |
| Barbeau, A; Gonce, M | 1 |
| Chase, TN; Glaubiger, GA; Shoulson, I | 1 |
| Ekel, TM; Hearing, VJ | 1 |
| Galea-Debono, A; Jenner, P; Marsden, CD; Parkes, JD; Tarsy, D; Walters, J | 1 |
| Moore, KE; Wuerthele, SM | 1 |
| Thut, PD | 1 |
| Delini-Stula, A; Maître, L; Waldmeier, PC | 1 |
| Mizuno, Y; Obayashi, T; Ueki, A; Yoshida, M | 1 |
| Kehr, W | 1 |
| Baker, J; Iversen, LL; Iversen, SD; Pilling, JB; Robbins, T | 1 |
| Altman, N; Glassman, A; Gruen, PH; Halpern, FS; Sachar, EJ; Sassin, J | 1 |
| Nurzia, A | 1 |
| Hellström, S | 1 |
| Cheng, LK; Fung, HL; Levitt, M | 1 |
| Brossi, A; Bruderer, H; Focella, A; Teitel, S | 1 |
| Cotzias, GC; Hsieh, RS; Kraner, HW; Miller, ST; Papavasiliou, PS | 1 |
| Cohen, HP; Jacobson, RL; Martin, WE; Tolosa, ES | 1 |
| Colpaert, FC; Laduron, P; Lal, H | 1 |
| Fahn, S; Lane, E; Makadon, H; Prasad, AL; Snider, S | 1 |
| Birkmayer, W; Riederer, P | 1 |
| Cotzias, GC; Tang, LC | 1 |
| Björklund, A; Brundin, P; Gustavii, B; Langston, JW; Lindvall, O; Rehncrona, S; Snow, B; Tetrud, J; Widner, H | 1 |
| Calne, DB; Fahn, S; Heiman, GA; Nygaard, TG; Snow, BJ; Takahashi, H | 1 |
| Kaiser, R; Ziegler, G | 1 |
| Goshima, Y; Kubo, T; Misu, Y; Nakamura, S; Yue, JL | 1 |
| Kim, HS; Kim, SH; Oh, KW; Rheu, HM | 1 |
| De Klippel, N; Deleu, D; Ebinger, G; Herregodts, P; Michotte, Y; Sarre, S | 1 |
| Kahn, V; Schved, F | 1 |
| Argentini, M; Cogoli-Greuter, M; Mäder, T; Weinreich, R; Wiese, C; Winterhalter, KH | 1 |
| Brooks, DJ; Findley, LJ; Ibanez, V; Marsden, CD; Playford, ED; Sawle, GV; Thompson, PD | 1 |
| Cogoli-Greuter, M; Weinreich, R; Wiese, C; Winterhalter, KH | 1 |
| Barber, HE; Boateng, YA; Lee, MR; MacDonald, TM; Petrie, JC | 1 |
| Labruyere, J; Olney, JW; Price, MT; Stewart, GR; Wang, GJ; Zorumski, CF | 1 |
| Cummings, J; Matheson, LM; Maurice, L; Smyth, JF | 1 |
| Engel, JA; Hulthe, P; Johannessen, K; Pettersson, G | 1 |
| Barrio, JR; Luxen, A; Melega, WP; Nissenson, CH; Perlmutter, MM; Phelps, ME | 1 |
| Barthelmebs, M; Ehrhardt, JD; Grima, M; Imbs, JL; Vailly, B; Velly, J | 1 |
| Cummings, J; Matheson, LM; Smyth, JF | 1 |
| Bondarenko, NA; Kudrin, VS; Miroshnichenko, II; Rayevsky, KS | 1 |
| Kent, AP; Stern, GM; Webster, RA | 1 |
| De Herdt, P; Maitre, L; Waldmeier, PC | 1 |
| Carlsson, A; Eriksson, T; Wiesel, K | 1 |
| Casagrande, C; Ferrini, R; Merlo, L; Miragoli, G; Semeraro, C | 1 |
| Bohmaker, K; Friedhoff, AJ; Goldstein, M; Meller, E; Namba, Y | 1 |
| Black, MJ; Brandt, RB | 1 |
| Bazan, E; de Yebenes, JG; Mena, MA; Muradas, V; Reiriz, J | 1 |
| Cedarbaum, JM; Dhar, AK; Kutt, H; McDowell, FH; Watkins, S | 1 |
| Bitton, V; Melamed, E; Zelig, O | 1 |
| Chirakal, R; Firnau, G; Garnett, ES | 2 |
| Clark, JC; Firnau, G; Garnett, ES; Jones, T; Leenders, KL; Marsden, CD; Nahmias, C; Palmer, AJ; Quinn, N | 1 |
| Abeling, NG; Overmars, H; van Gennip, AH; Voûte, PA | 1 |
| Nagatsu, T; Naoi, M | 1 |
| Chirakal, R; Firnau, G; Garnett, ES; Nahmias, C; Sood, S | 1 |
| Adam, MJ; Ammann, W; Bergstrom, M; Harrop, R; Laihinen, A; Martin, WR; Rogers, JG; Ruth, TJ; Sayre, CI; Stoessl, AJ | 1 |
| Albani, C; Asper, R; Baumgartner, G | 1 |
| Ichinose, H; Kumagai, H; Nagatsu, T; Suzuki, H; Togari, A | 1 |
| Bragina, NN; Il'icheva, RF; Piasetskaia, MV; Potapov, AA | 1 |
| Da Prada, M; Haefely, WE; Kettler, R; Schaffner, R; Zürcher, G | 1 |
| Barra, D; Dominici, P; Schininà, ME; Simmaco, M; Tancini, B; Voltattorni, CB | 1 |
| Cashaw, JL; Davis, VE; Geraghty, CA; McLaughlin, BR | 1 |
| Kurlan, R; Lichter, D; Miller, C; Nutt, JG; Rothfield, KP; Shoulson, I; Woodward, WR | 1 |
| Cannon-Spoor, E; Chuang, LW; Costa, E; Freed, WJ; Karoum, F; Wyatt, RJ | 1 |
| Sławińska, D; Sławiński, J | 1 |
| Martin, WR | 1 |
| Amanova, ZN; Badalian, LO; Grinio, ZN; Sadovskaia, IuE; Temin, PA | 1 |
| Baumeister, A; Breese, GR; Frye, GD; Mueller, RA; Napier, TC | 1 |
| Munro, HN; Roel, LE; Weiss, BF; Wurtman, RJ | 1 |
| Garelis, E; Lal, S; Sourkes, TL; Young, SN | 1 |
| Fawcett, CP; Krulich, L; McCann, SM; Ojeda, SR | 1 |
| Sandler, M | 1 |
| Bautz, G; Horst, WD; Renyi, E; Spirt, N | 1 |
| Kadzielawa, K | 1 |
| Granerus, AK; Jagenburg, R; Rödjer, S; Svanborg, A | 1 |
| Buser, P; Valin, A; Viala, D | 1 |
| McDowell, FH; Sweet, RD | 1 |
| Fermaglich, J | 1 |
| Steinhäusl, H | 1 |
| Baker, H; Joh, TH; Kawano, T; Margolis, FL | 1 |
| Carlberg, M; Jergil, B; Lindbladh, C; Rosengren, E | 1 |
| Koller, WC | 1 |
| Fujita, K; Inoue, S; Ito, S | 1 |
| Gleĭzer, MA; Karlov, VA | 1 |
| Bolster, JM; Vaalburg, W; Van der Molen, HD; Van Dijk, T; Van Veen, W; Woldring, MG; Wynberg, H | 1 |
| Tang, LC | 1 |
| Carlsson, A; Eriksson, T; Granérus, AK; Linde, A; Magnusson, T | 1 |
| Watanabe, H | 1 |
| Beers, MF; Hurtig, H; Melvin, G; Scarpa, A; Stern, M | 1 |
| Yoshimura, Y | 1 |
| Fujita, K; Inoue, S; Ito, S; Nagatsu, T; Shamoto, M; Takeuchi, J; Yamamoto, Y | 1 |
| Berggren, U; Engel, J | 1 |
| Fujita, K; Ito, S; Teradaira, R | 1 |
| Bailey, R; Crisp, E; Jackson, DM; Jenkins, O | 1 |
| Vartanian, KZ | 1 |
| Lee, MR | 1 |
| Fahn, S; Prasad, AL | 1 |
| Uono, M | 1 |
| Jung, MJ; Palfreyman, MG; Ribéreau-Gayon, G; Wagner, J; Zraïka, M | 1 |
| Bédard, PJ; Côté, PY; Grégoire, L; Parent, A; Roy, E | 1 |
| Christensen, NJ; Eldrup, E; Jacobsen, J; Mogensen, P; Pakkenberg, H | 1 |
| García-Borrón, JC; Jimenez-Cervantes, C; Lozano, JA; Solano, F; Valverde, P | 1 |
| Lang, AE | 1 |
| Eriksson, T; Holmgren, B | 1 |
| Bertini, E; Di Capua, M | 1 |
| Lang, A; Männistö, PT; Rauhala, P; Vasar, E | 1 |
| Creveling, CR; Inoue, K; Isomura, G; Karasawa, N; Nagatsu, I | 1 |
| Gordin, A; Kaakkola, S; Männistö, PT | 1 |
| Brooks, DJ; Lammerstma, AA; Lees, AJ; Playford, ED; Sawle, GV; Turjanski, N; Weeks, R | 1 |
| McGrath, BP; Secombe, J; Shimizu, K; Wang, ZQ; Way, D | 2 |
| Drieman, JC; Smits, JF; Struijker Boudier, HA; Thijssen, HH; van Essen, H; van Kan, FJ | 1 |
| Brooks, DJ; Burn, DJ; Lammertsma, AA; Luthra, S; Morrish, PK; Osman, S; Sawle, GV; Snow, BJ | 1 |
| Bennett, JP; Landow, ER; Schuh, LA | 1 |
| Defer, GL; Degos, JD; Malapert, D; Remy, P; Ricolfi, F; Samson, Y | 1 |
| Pestana, M; Soares-da-Silva, P | 1 |
| Goshima, Y; Misu, Y | 1 |
| Goshima, Y; Misu, Y; Miyamae, T; Nakamura, S; Yue, JL | 1 |
| Björklund, A; Brooks, D; Brundin, P; Frackowiak, R; Lindvall, O; Marsden, CD; Odin, P; Rothwell, JC; Sawle, G; Widner, H | 1 |
| Goshima, Y; Kubo, T; Misu, Y; Miyamae, T; Nakamura, S; Yue, JL | 1 |
| Calne, DB; Nygaard, TG; Snow, BJ; Takahashi, H | 2 |
| Goshima, Y; Misu, Y; Yue, JL | 1 |
| Kuchel, OG; Shigetomi, S | 1 |
| Cedarbaum, JM; Evans, A; Gjedde, A; Guttman, M; Kuwabara, H; Léger, G; Reches, A | 1 |
| Bennett, JP; Schuh, LA | 1 |
| Bhatia, K; Brooks, DJ; Burn, DJ; Marsden, CD; Sawle, GV; Turjanski, N | 1 |
| Soares-da-Silva, P; Vieira-Coelho, MA | 2 |
| Kanazawa, I; Murata, M | 2 |
| Cumming, P; Gjedde, A; Guttman, M; Hoshi, H; Kuwabara, H; Léger, G | 1 |
| Bhatt, MH; Calne, DB; Nakamura, K; Nomoto, M; Okada, A; Osame, M; Snow, BJ | 1 |
| Kuchel, O; Shigetomi, S | 1 |
| Folio, CJ; Goldstein, DS; Grossman, E; Keiser, HR; Kopin, IJ; Wolfovitz, E | 1 |
| Channing, MA; Eckelman, WC; Kawai, K; Kubodera, A; Ohta, H | 2 |
| Larsson, BS; Mårs, U | 1 |
| Aquilonius, SM; Hartvig, PG; Långström, B; Tedroff, J | 1 |
| Narabayashi, H | 1 |
| Brannan, T; Prikhojan, A; Yahr, MD | 1 |
| Dubinsky, R; Hubble, JP; Koller, WC; Lyons, K; McGuire, D; Pahwa, R | 1 |
| Freestone, S; Johnston, NR; Lee, MR; Li Kam Wa, TC; Samson, RR | 1 |
| Akiguchi, I; Fukuyama, H; Hanakawa, T; Kato, M; Kimura, J; Shibasaki, H | 1 |
| da Cruz Vieira, I; Fatibello-Filho, O | 1 |
| Haavik, J | 1 |
| Kang, UJ; Leff, SE; Mandel, RJ; Rendahl, KG; Spratt, SK | 1 |
| Cabaret, M; Caparros-Lefebvre, D; Godefroy, O; Petit, H; Rémy, P; Samson, Y; Steinling, M | 1 |
| Bennett, JP; Laws, ER; Skalabrin, EJ | 1 |
| Arai, N; Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T | 1 |
| Bolliger, C; de Toledo, FG; Dousa, TP; Thompson, MA; Tyce, GM | 1 |
| Brown, WD; DeJesus, OT; Holden, JE; Malischke, LM; Nickles, RJ; Oakes, TR; Roberts, AD; Schueller, MJ; Taylor, MD | 1 |
| Fasth, KJ; Hartvig, P; Långström, B; Tedroff, J; Torstenson, R | 1 |
| Brousolle, E; Dentresangle, C; Froment, JC; Guerin, J; Lavenne, F; Le Bars, D; Pierre, C; Pollak, P; Veyre, L | 1 |
| Aigner, TG; Doudet, D; Fernández-Ruiz, J | 1 |
| Akaike, A; Arai, N; Fujita, K; Furukawa, N; Goshima, Y; Hashimoto, M; Misu, Y; Miyamae, T; Sasaki, Y; Yamamoto, I | 1 |
| Berndt, TJ; Knox, FG; Nath, KA; Sadiq, S | 1 |
| Imahori, Y; Kawano, H; Misawa, A; Sawada, T; Takeuchi, Y | 1 |
| Calne, DB; de la Fuente-Fernández, R; Kishore, A; Mak, EK; Pal, PK; Ruth, TJ; Schulzer, M; Snow, BJ; Stoessl, AJ; Vingerhoets, FJ | 1 |
| Brooks, DJ | 2 |
| Jenner, P; Rose, S; Treseder, SA | 1 |
| Jenner, P; McNaught, KS | 1 |
| Arai, N; Fujita, K; Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T; Ohshima, E; Suzuki, F | 1 |
| Arai, N; Fujita, K; Furukawa, N; Goshima, Y; Misu, Y; Miyamae, T; Ohshima, E; Sasaki, Y; Suzuki, F | 1 |
| Bergman, J; Eronen, E; Eskola, O; Niinivirta, M; Oikonen, V; Rinne, UK; Ruottinen, HM; Solin, O; Sonninen, P | 1 |
| Hadjiconstantinou, M; Neff, NH; Wemlinger, TA | 1 |
| Kannari, K; Matsunaga, M; Shen, H; Suda, T; Yamato, H | 1 |
| Blandini, F; Fancellu, R; Mangiagalli, A; Martignoni, E; Nappi, G; Pacchetti, C; Samuele, A | 1 |
| Hainzl, D; Loureiro, AI; Parada, A; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Calne, DB; de la Fuente-Fernández, R; Hwang, WJ; Tsui, JK | 1 |
| Bartholomé, B; Bartholomé, K; Blau, N; Bonafé, L; Skrygan, M | 1 |
| Barrio, JR; Cheng, DW; Huang, SC; Namavari, M; Satyamurthy, N; Yee, RE | 1 |
| Buhmann, C; Oechsner, M; Strauss, J; Stuerenburg, HJ | 1 |
| DeJesus, OT; Holden, JE; Nickles, RJ; Roberts, AD; Shelton, SE | 1 |
| Fowler, B; Kuhn, W; Müller, T; Woitalla, D | 1 |
| Jennings, D; Marek, K; Seibyl, J | 1 |
| Bailey, DL; Brooks, DJ; Ito, K; Morrish, PK; Pavese, N; Rakshi, JS; Uema, T | 1 |
| Goshima, Y; Hashimoto, M; Miyamae, T; Yamamoto, I | 1 |
| Parada, A; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Cao, F; Sun, S; Tong, ET | 1 |
| PENNEFATHER, JN; RAND, MJ | 1 |
| PERRY, JE; WIEGAND, RG | 1 |
| DEGKWITZ, R; FROWEIN, R; KULENKAMPFF, C; MOHS, U | 1 |
| CAHN, J; HELBECQUE, C; HEROLD, M; JULLIARD, AM; LASJAUNIAS, T | 1 |
| BARRE, N; CAHN, J; HEROLD, M | 1 |
| KANIKE, K; NAMBA, J; YOSHIDA, H | 1 |
| CARLSSON, A; SEIDEN, LS | 2 |
| GERSTENBRAND, F; PATEISKY, K; PROSENZ, P | 1 |
| KANIIKE, K; NAMBA, J; YOSHIDA, H | 1 |
| KANIIKE, K; YOSHIDA, H | 2 |
| IMAIZUMI, R; KANIIKE, K; NAMBA, J; YOSHIDA, H | 1 |
| BAUMANN, D; UMBACH, W | 1 |
| HIRSCHMANN, J; MAYER, K | 1 |
| FUXE, K; HILLARP, NA | 1 |
| DIEMATH, HE; ENGE, S; HEPPNER, F; LECHNER, H | 1 |
| BIRKMAYER, W; HORNYKIEWICZ, O | 1 |
| MANTEGAZZA, P; RIVA, M | 1 |
| Almeida, L; Falcão, A; Loureiro, A; Machado, R; Maia, J; Silveira, P; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Brooks, DJ; Frey, KA; Marek, KL; Oakes, D; Paty, D; Prentice, R; Shults, CW; Stoessl, AJ | 1 |
| Bergman, J; Eskola, O; Forsback, S; Grönroos, T; Haapalinna, A; Haaparanta, M; Marjamäki, P; Niemi, R; Rinne, J; Solin, O | 1 |
| DeJesus, OT; Doudet, DJ; Endres, CJ; Holden, JE; Nickles, JR; Uno, H | 1 |
| Muhlack, S; Müller, T; Przuntek, H; Twiehaus, S; Welnic, J; Woitalla, D | 1 |
| Bailey, DL; Brooks, DJ; Pavese, N; Remy, P; Whone, AL | 1 |
| Cumming, P; Danielsen, EH; Gjedde, A; Kumakura, Y; Reilhac, A | 1 |
| Hnasko, TS; Palmiter, RD; Sotak, BN | 1 |
| Bonnet, S; Boumendjel, A; Mariotte, AM; Okombi, S; Perrier, E; Rival, D | 1 |
| Adams, J; de la Fuente-Fernández, R; Schulzer, M; Sossi, V; Stoessl, J | 1 |
| Mink, JW | 1 |
| Deleu, D; Hanssens, Y | 1 |
| Konno, R; Wang, YX; Wu, M; Zhou, XJ | 1 |
| Borsini, F; Morelli, M; Pinna, A; Pontis, S | 1 |
| Chen, Y; Cheong, S; Guo, C; Lim, L; Reboud, J; Tang, K; Zhang, Q | 1 |
| Brown, L; Dickson, D; Farrer, M; Skipper, L; Solida, A; Vingerhoets, FJ; Wider, C; Wszolek, ZK | 1 |
| Horita, M; Masuoka, N; Ogino, K; Sano, K; Sauriasari, R; Takaki, J; Takemura, Y; Takigawa, T; Tsutsui, K; Wang, DH | 1 |
| Brotchie, JM; Fox, SH; Johnston, TH; Millan, MJ; Visanji, NP | 1 |
| Kuhn, W; Müller, T | 1 |
| Muhlack, S; Müller, T | 1 |
| Rajaram, A; Ramasami, T; Usha, R | 1 |
| Cumming, P; Kumakura, Y | 1 |
| Bakay, RA; Deogaonkar, M; Lieu, CA; Subramanian, T | 1 |
| Endres, CJ; Hayashi, T; Iida, H; Kumakura, Y; Matsubara, K; Minato, K; Watabe, H | 1 |
| Brooks, DJ; Lewis, SJ; Pavese, N; Rivero-Bosch, M; Whone, AL | 1 |
| Abbs, JH; Bendlin, BB; Brooks, BR; Brown, WD; Chung, MK; Dejesus, OT; Dogan, S; Gallagher, CL; Holden, JE; Johnson, SC; Konopacki, RA; Nickles, RJ; Oakes, TR; Pyzalski, RW; Xu, G | 1 |
| Blau, N; Dill, P; Jakobs, C; Schneider, J; Tekin, M; Thöny, B; Trachsel, D; Weber, P | 1 |
| Cederfjäll, E; Kirik, D; Sahin, G | 1 |
| Groves, MJ; Morris, JG; Parsons, RL; Trounce, JR | 1 |
| Bours, V; Caberg, JH; Dive, D; Garraux, G; Jamar, M; Moonen, G; Vanbellinghen, JF | 1 |
| Eskola, O; Jokinen, P; Joutsa, J; Kaasinen, V; Rinne, JO | 1 |
| Gobikrishnan, S; Indrawan, N; Min, K; Park, DH; Park, JH; Park, SH; Rahman, SF; Yoo, YJ | 1 |
| Fukui, M; Kang, KS; Wen, Y; Yamabe, N; Zhu, BT | 1 |
| Joshi, V; Mohan, V; Nathan, J; Panjwani, S; Thakurdesai, PA | 1 |
| Cesar, TS; Ferguson, MC; Garland, EM; Lonce, S; Robertson, D | 1 |
| Arbizu, J; Collantes, M; DiCaudo, C; Luquin, MR; Marcilla, I; Ordóñez, C; Peñuelas, I; Riverol, M | 1 |
| Browne, C; de Hatten, X; Dutta, P; Evmenenko, G; Gulino, A; Kaminker, R; Lahav, M; Lupo, F; Nitschke, JR; van der Boom, ME | 1 |
| Fukiwake, T; Hasegawa, T; Motoki, Y; Saijo, M; Takahashi, K | 1 |
| Bendlin, BB; Buyan-Dent, L; Christian, BT; DeJesus, OT; Gallagher, CL; Harding, SJ; Holden, JE; Li, CT; Nickles, RJ; Oh, J; Okonkwo, O; Palotti, M; Stone, CK | 1 |
| Cardoso, MA; de Carvalho, KA; de Francisco, TM; de Oliveira Vilhena, R; Gasparetto, JC; Guimarães de Francisco, TM; Martins, CA; Pontarolo, R; Ribeiro, RP | 1 |
| Cao, L; Hao, H; Hao, K; Li, F; Liu, H; Qi, Q; Wang, H | 1 |
| Harada, N; Kakiuchi, T; Kanazawa, M; Muramatsu, S; Ohba, H; Tsukada, H | 1 |
| Fu, WQ; Gu, ZG; Wu, X; Zhang, J | 1 |
| Bishnoi, P; Charde, SY; Raut, PP | 1 |
| Asanuma, M; Miyazaki, I | 1 |
| Herrman, L; Kinkel, M; Muhlack, S; Müller, T | 1 |
| Gao, N; Qu, X; Ren, J; Sun, Y; Zhao, C | 1 |
| Cheng, G; Cong, H; Li, S; Wang, H; Xu, F; Young, M | 1 |
| Barclay, CL; Barua, NU; Blinder, S; Boca, M; Boiko, C; Broadfoot, J; Cronin, D; Dharia, S; Fibiger, HC; Gill, SS; Harrison, R; Howell, M; Irving, C; Johnson, D; Johnson, GA; Kinch, S; Lawrence, AD; Lewis, O; Longpre, L; Luz, M; Marshall, C; Mohr, E; Mooney, L; Pritchard, G; Schroers, C; Skinner, P; Sossi, V; Stoessl, AJ; Whone, AL; Woolley, M | 1 |
| Agostinho, P; Aguiar, AS; Cunha, RA; Ferreira, SG; Prediger, RD; Silva, HB; Speck, AE; Tomé, ÂR | 1 |
| Cao, X; Cong, L; Fu, J; Gao, TL; Han, P; Jiang, JD; Li, XY; Lin, Y; Ma, SR; Pan, LB; Peng, R; Shou, JW; Tong, Q; Wang, Y; Wen, BY; Yu, H; Yu, JB; Zhang, XF; Zhang, ZW; Zhao, ZX | 1 |
| Kleppe, R; Ruoff, P; Waheed, Q | 1 |
21 review(s) available for levodopa and dihydroxyphenylalanine
| Article | Year |
|---|---|
Pharmaco-behavioral effects of hypothalamic peptides in animals and man: focus on thyrotropin-releasing hormone and neurotensin.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Dihydroxyphenylalanine; Drug Synergism; Humans; Hypnotics and Sedatives; Hypothalamus; Levodopa; Mental Disorders; Neural Inhibition; Neurotensin; Neurotransmitter Agents; Serotonin; Thyrotropin-Releasing Hormone | 1978 |
Monoamine precursors and analogues.
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; Drug Interactions; Drug Synergism; Humans; Levodopa; Mice; Parkinson Disease; Rats; Receptors, Drug; Stimulation, Chemical; Tremor; Tryptophan; Tyrosine | 1975 |
Decarboxylase inhibitors.
Topics: Amino Acids; Animals; Behavior; Behavior, Animal; Benserazide; Brain; Capillaries; Carboxy-Lyases; Catecholamines; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Humans; Levodopa; Mice; Rabbits; Rats; Time Factors | 1975 |
Compulsive gnawing.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Behavior, Animal; Benserazide; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Iproniazid; Levodopa; Male; Methyldopa; Methyltyrosines; Rats; Serotonin; Structure-Activity Relationship; Time Factors | 1976 |
[The current treatment of Parkinson's disease].
Topics: Amantadine; Antidepressive Agents, Tricyclic; Dihydroxyphenylalanine; Drug Combinations; Histamine Antagonists; Humans; Levodopa; Mental Disorders; Movement Disorders; Neurosecretory Systems; Parasympatholytics; Parkinson Disease; Physical Therapy Modalities; Pyridoxine; Stereotaxic Techniques | 1976 |
Cardiovascular and renal action of dopaminergic prodrugs.
Topics: Animals; Cardiotonic Agents; Cats; Chemical Phenomena; Chemistry; Deoxyepinephrine; Dihydroxyphenylalanine; Dogs; Dopamine; Dopamine Agents; Drug Design; Female; Heart Failure; Hemodynamics; Humans; Kidney; Levodopa; Male; Prodrugs; Rabbits; Rats; Vasodilator Agents | 1989 |
Positron emission tomography in movement disorders.
Topics: Brain; Cerebrovascular Circulation; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dystonia; Glucose; Humans; Huntington Disease; Levodopa; Movement Disorders; Oxygen Consumption; Parkinson Disease; Synapses; Tomography, Emission-Computed | 1985 |
Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies.
Topics: Animals; Biological Transport, Active; Brain; Cats; Cerebral Ventricles; Cerebrospinal Fluid; Choroid Plexus; Dihydroxyphenylalanine; Dogs; Dopamine; Fenclonine; Glycols; Haplorhini; Homovanillic Acid; Humans; Hydrocephalus; Hydroxyindoleacetic Acid; Levodopa; Methoxyhydroxyphenylglycol; Parkinson Disease; Phenylacetates; Probenecid; Serotonin; Spinal Cord; Spinal Cord Injuries; Tryptophan | 1974 |
Catecholaminergic control of gonadotropin and prolactin secretion with particular reference to the possible participation of dopamine.
Topics: Animals; Brain Mapping; Castration; Dihydroxyphenylalanine; Dopamine; Drug Interactions; Electric Stimulation; Epinephrine; Estrogens; Female; Fenclonine; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Haloperidol; Hypothalamus; In Vitro Techniques; Levodopa; Luteinizing Hormone; Male; Norepinephrine; Pargyline; Phenoxybenzamine; Pimozide; Progesterone; Prolactin; Propranolol; Rats; Serine; Synaptic Transmission; Thiocarbamates; Thyrotropin-Releasing Hormone; Time Factors | 1974 |
Dopamine and the kidney.
Topics: Animals; Dihydroxyphenylalanine; Dogs; Dopamine; Edema; Female; Glutamates; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Levodopa; Rats; Receptors, Dopamine; Renin-Angiotensin System; Sodium Chloride | 1982 |
Hemiatrophy, juvenile-onset exertional alternating leg paresis, hypotonia, and hemidystonia and adult-onset hemiparkinsonism: the spectrum of hemiparkinsonism-hemiatrophy syndrome.
Topics: Antiparkinson Agents; Blood Glucose; Carbidopa; Contrast Media; Deoxyglucose; Dihydroxyphenylalanine; Dominance, Cerebral; Drug Combinations; Female; Fluorodeoxyglucose F18; Functional Laterality; Hemiplegia; Humans; Levodopa; Middle Aged; Muscle Hypotonia; Muscular Atrophy; Neurologic Examination; Parkinson Disease, Secondary; Physical Exertion; Substantia Nigra; Tomography, Emission-Computed | 1995 |
General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase.
Topics: Animals; Behavior, Animal; Benzophenones; Catechol O-Methyltransferase Inhibitors; Catecholamines; Catechols; Dihydroxyphenylalanine; Humans; Levodopa; Microdialysis; Nitriles; Nitrophenols; Pentanones; Tolcapone; Tomography, Emission-Computed | 1994 |
Is L-dopa an endogenous neurotransmitter?
Topics: Animals; Dihydroxyphenylalanine; Humans; Levodopa; Neurotransmitter Agents; Receptors, Cell Surface | 1993 |
Review on the relationship between nicotinic acetylcholine receptors and dopaminergic neurotransmission in the central nervous system--dopa is an endogenous neuroactive substance.
Topics: Animals; Catecholamines; Corpus Striatum; Dihydroxyphenylalanine; In Vitro Techniques; Levodopa; Motor Activity; Nicotine; Rats; Receptors, Nicotinic; Synapses | 1993 |
Functional positron emission tomographic studies of striatal dopaminergic activity. Changes induced by drugs and nigrostriatal degeneration.
Topics: Animals; Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Neostriatum; Nerve Degeneration; Substantia Nigra; Tomography, Emission-Computed | 1996 |
The neural mechanisms and progressive nature of symptoms of Parkinson's disease--based on clinical, neurophysiological and morphological studies.
Topics: Dihydroxyphenylalanine; Disease Progression; Dyskinesia, Drug-Induced; Humans; Levodopa; Movement Disorders; Nervous System; Parkinson Disease | 1995 |
PET studies and motor complications in Parkinson's disease.
Topics: Antiparkinson Agents; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dyskinesia, Drug-Induced; Fluorine Radioisotopes; Humans; Levodopa; Neural Pathways; Opioid Peptides; Parkinson Disease; Pulse Therapy, Drug; Putamen; Receptors, Opioid; Tomography, Emission-Computed | 2000 |
Do dopamine agonists or levodopa modify Parkinson's disease progression?
Topics: Animals; Antiparkinson Agents; Benzothiazoles; Carrier Proteins; Dihydroxyphenylalanine; Disease Progression; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Humans; Indoles; Iodine Radioisotopes; Levodopa; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Parkinson Disease; Pramipexole; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Tropanes | 2002 |
Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease.
Topics: Animals; Basal Ganglia; Biomarkers; Cocaine; Diagnostic Imaging; Dihydroxyphenylalanine; Disease Progression; Dopamine Plasma Membrane Transport Proteins; Humans; Levodopa; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuropeptides; Parkinson Disease; Radiopharmaceuticals; Technology Assessment, Biomedical; Tetrabenazine; Tomography, Emission-Computed, Single-Photon; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
PET studies of cerebral levodopa metabolism: a review of clinical findings and modeling approaches.
Topics: Animals; Brain; Computer Simulation; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Humans; Levodopa; Parkinson Disease; Pharmacokinetics; Positron-Emission Tomography | 2009 |
Key factors determining the efficacy of gene therapy for continuous DOPA delivery in the Parkinsonian brain.
Topics: Animals; Antiparkinson Agents; Aromatic-L-Amino-Acid Decarboxylases; Brain Chemistry; Dependovirus; Dihydroxyphenylalanine; Drug Delivery Systems; Genetic Therapy; Genetic Vectors; Humans; Levodopa; Parkinson Disease; Tyrosine 3-Monooxygenase | 2012 |
15 trial(s) available for levodopa and dihydroxyphenylalanine
| Article | Year |
|---|---|
Plasma concentrations of L-dopa and 3-methoxydopa and improvement in clinical ratings and motor performance in patients with Parkinsonism treated with L-dopa alone or in combination with amantadine.
Topics: Activities of Daily Living; Amantadine; Clinical Trials as Topic; Dihydroxyphenylalanine; Disability Evaluation; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Motor Skills; Parkinson Disease; Time Factors | 1975 |
Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adult; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Fetal Tissue Transplantation; Humans; Immunosuppression Therapy; Levodopa; Male; Mesencephalon; Motor Activity; Parkinson Disease, Secondary; Putamen; Stereotaxic Techniques; Time Factors; Tomography, Emission-Computed | 1992 |
[Experiences in the treatment of Parkinson's disease with a combination drug: L-dopa plus decarboxylase inhibitor (Ro 8-0576)].
Topics: Benserazide; Carboxy-Lyases; Clinical Trials as Topic; Dihydroxyphenylalanine; Drug Combinations; Evaluation Studies as Topic; Gastrointestinal Diseases; Gymnastics; Humans; Hydrazines; Levodopa; Parkinson Disease; Speech Therapy | 1973 |
The effect of entacapone (OR-611) on brain [18F]-6-L-fluorodopa metabolism: implications for levodopa therapy of Parkinson's disease.
Topics: Aged; Brain; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dihydroxyphenylalanine; Drug Synergism; Female; Fluorine Radioisotopes; Humans; Levodopa; Male; Middle Aged; Nitriles; Occipital Lobe; Parkinson Disease; Tomography, Emission-Computed | 1994 |
Derivation of urinary dopamine from plasma dihydroxyphenylalanine in humans.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Dihydroxyphenylalanine; Dopamine; Female; Humans; Kidney; Levodopa; Male; Middle Aged; Sodium, Dietary | 1993 |
Early morning akinesia in Parkinson's disease: effect of standard carbidopa/levodopa and sustained-release carbidopa/levodopa.
Topics: Aged; Carbidopa; Circadian Rhythm; Cross-Over Studies; Delayed-Action Preparations; Dihydroxyphenylalanine; Double-Blind Method; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease | 1996 |
Renal metabolism and effects of the glutamyl derivatives of L-dopa and 5-hydroxytryptophan in man.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Adult; Cross-Over Studies; Dihydroxyphenylalanine; Dipeptides; Dopamine; Humans; Hydroxyindoleacetic Acid; Kidney; Levodopa; Male; Serotonin; Single-Blind Method; Sodium | 1996 |
A comparison of the progression of early Parkinson's disease in patients started on ropinirole or L-dopa: an 18F-dopa PET study.
Topics: Aged; Antiparkinson Agents; Dihydroxyphenylalanine; Disease Progression; Fluorine Radioisotopes; Follow-Up Studies; Humans; Indoles; Levodopa; Middle Aged; Parkinson Disease; Tomography, Emission-Computed | 2002 |
Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide.
Topics: Acetophenones; Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Catechol O-Methyltransferase Inhibitors; Cross-Over Studies; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Tyrosine | 2003 |
Chronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's disease.
Topics: Adult; Aged; Analysis of Variance; Antiparkinson Agents; Area Under Curve; Benserazide; Biological Availability; Dihydroxyphenylalanine; Drug Administration Routes; Drug Administration Schedule; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Time Factors; Tyrosine | 2004 |
A technique for standardized central analysis of 6-(18)F-fluoro-L-DOPA PET data from a multicenter study.
Topics: Algorithms; Antiparkinson Agents; Canada; Dihydroxyphenylalanine; Dopamine Agents; France; Germany; Humans; Image Interpretation, Computer-Assisted; Indoles; Levodopa; Parkinson Disease; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tomography, Emission-Computed; Treatment Outcome; United Kingdom | 2004 |
Levodopa effect on [18F]fluorodopa influx to brain: normal volunteers and patients with Parkinson's disease.
Topics: Adrenergic beta-Agonists; Aged; Aged, 80 and over; Blood-Brain Barrier; Body Fluid Compartments; Brain; Cerebellum; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Drug Synergism; Female; Humans; Levodopa; Magnetic Resonance Imaging; Male; Metabolic Clearance Rate; Middle Aged; Parkinson Disease; Presynaptic Terminals; Putamen; Reference Values; Tomography, Emission-Computed | 2004 |
Homocysteine levels after acute levodopa intake in patients with Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Dihydroxyphenylalanine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Severity of Illness Index; Statistics as Topic; Time Factors; Tyrosine | 2009 |
Plasma dopa concentrations after different preparations of levodopa in normal subjects.
Topics: Adult; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Biological Availability; Dihydroxyphenylalanine; Female; Humans; Levodopa; Male; Metoclopramide; Solubility | 1976 |
Efficacy and safety of standardized extract of Trigonella foenum-graecum L seeds as an adjuvant to L-Dopa in the management of patients with Parkinson's disease.
Topics: Adjuvants, Pharmaceutic; Aged; Dihydroxyphenylalanine; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Plant Extracts; Seeds; Trigonella | 2014 |
245 other study(ies) available for levodopa and dihydroxyphenylalanine
| Article | Year |
|---|---|
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.
Topics: Benzylidene Compounds; Carcinoma, Squamous Cell; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Structure; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Structure-Activity Relationship | 1989 |
Evaluation of scavenging rate constants of DOPA and tyrosine enantiomers against multiple reactive oxygen species and methyl radical as measured with ESR trapping method.
Topics: Dihydroxyphenylalanine; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Kinetics; Levodopa; Methane; Reactive Oxygen Species; Spin Trapping; Stereoisomerism; Tyrosine | 2015 |
The neurochemistry of Parkinson's disease: effect of L-dopa therapy.
Topics: Aged; Brain; Catechol O-Methyltransferase; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Female; Homovanillic Acid; Humans; Levodopa; Male; Methyldopa; Middle Aged; Monoamine Oxidase; Parkinson Disease; Tyrosine 3-Monooxygenase | 1975 |
Determination of some L-3,4-dihydroxyphenylalanine and dopamine metabolites in urine by means of mass fragmentography.
Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; Adult; Aging; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Flavoring Agents; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Humans; Infant; Infant, Newborn; Lactates; Levodopa; Middle Aged; Neuroblastoma; Phenylethyl Alcohol | 1978 |
Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey.
Topics: Animals; Apomorphine; Behavior, Animal; Cerebral Cortex; Cognition; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Haplorhini; Levodopa; Macaca mulatta; Norepinephrine | 1979 |
Action of dopamine agonists on parkinson-like muscle rigidity induced by 6-aminonicotinamide.
Topics: 6-Aminonicotinamide; Animals; Brain Chemistry; Corpus Striatum; Diencephalon; Dihydroxyphenylalanine; Electromyography; Levodopa; Limbic System; Lisuride; Male; Muscles; Niacinamide; Parkinson Disease, Secondary; Rats; Tyrosine | 1979 |
Circulating levels of corticotrophin and cortisol after infusions of L-DOPA, dopamine and noradrenaline, in man.
Topics: Adrenocorticotropic Hormone; Blood Pressure; Catheterization; Cosyntropin; Dihydroxyphenylalanine; Dopamine; Humans; Hydrocortisone; Infusions, Parenteral; Insulin; Lactates; Levodopa; Norepinephrine; Parkinson Disease; Pulse; Sodium Chloride | 1975 |
[Dopa and dopamine agonists in depression (author's transl)].
Topics: Animals; Brain; Depression; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Receptors, Dopamine; Synaptic Transmission | 1979 |
Catecholamine and octopamine concentrations in brains of patients with Reye syndrome.
Topics: Brain Chemistry; Catecholamines; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Humans; Hypothalamus; Levodopa; Octopamine; Reye Syndrome | 1977 |
Neurochemical investigations of the interaction of N,N-dimethyltryptamine with dopaminergic system in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Brain; Corpus Striatum; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Female; Homovanillic Acid; Levodopa; Monoamine Oxidase; N,N-Dimethyltryptamine; Norepinephrine; Normetanephrine; Rats; Time Factors; Tryptamines; Tyramine | 1977 |
[Effect of DMBA and benz (alpha) anthracene on the biogenic amine level in the rat brain].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Biogenic Amines; Brain; Castration; Diethylstilbestrol; Dihydroxyphenylalanine; Drug Tolerance; Female; Hypothalamus; Levodopa; Male; Methylcholanthrene; Rats; Time Factors | 1977 |
Effects of L-dopa on putrescine levels in the brain and the liver of the rat.
Topics: Amino Acids; Animals; Brain Chemistry; Dihydroxyphenylalanine; Hypophysectomy; Levodopa; Liver; Male; Ornithine Decarboxylase; Putrescine; Rats; S-Adenosylmethionine; Spermidine; Time Factors | 1979 |
Effects of morphine, physostigmine and raphe nuclei stimulation on 5-hydroxytryptamine release from the cerebral cortex of the cat.
Topics: Animals; Brain Stem; Cats; Cerebral Cortex; Dihydroxyphenylalanine; Electric Stimulation; Electroencephalography; Female; Levodopa; Male; Morphine; Physostigmine; Raphe Nuclei; Rats; Serotonin; Species Specificity | 1979 |
Effect of a catechol-O-methyl transferase inhibitor, U-0521, with levodopa administration.
Topics: Animals; Behavior, Animal; Brain; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Homovanillic Acid; Levodopa; Male; Methyldopa; Propiophenones; Rats; Time Factors | 1979 |
The effect of L-DOPA on the ultrastructure of the adenohypophysis of the Chinese quail, Excalfactoria chinensis.
Topics: Animals; Dihydroxyphenylalanine; Endoplasmic Reticulum; Levodopa; Lysosomes; Male; Pituitary Gland, Anterior; Quail | 1979 |
Central dopamine receptors regulate blood eosinophilia in the rat.
Topics: Animals; Apomorphine; Aromatic Amino Acid Decarboxylase Inhibitors; Benzyl Alcohols; Brain; Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Eosinophils; Haloperidol; Hydrazines; Hypophysectomy; Leukocyte Count; Levodopa; Male; Phenylthiourea; Rats; Receptors, Dopamine | 1979 |
gamma-Glutamyl DOPA and gamma-glutamyl dopamine: effect on plasma glucose levels.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Glucose; Dihydroxyphenylalanine; Dopamine; Female; Homovanillic Acid; Levodopa; Pancreas; Rats; Time Factors | 1979 |
Electromyographical and biochemical studies on mutant Han-Wistar rats with progressive spastic paresis.
Topics: Adenylyl Cyclases; Animals; Brain; Dihydroxyphenylalanine; Dopamine; Electromyography; Female; Homovanillic Acid; Levodopa; Male; Mutation; Paresis; Rats; Serotonin | 1979 |
[Administration of the catecholamine precursor, L-DOPA, for evaluating their in vivo biosynthesis in hypertension].
Topics: Administration, Oral; Adult; Catecholamines; Circadian Rhythm; Dihydroxyphenylalanine; Dopamine; Epinephrine; Free Radicals; Humans; Hypertension; Levodopa; Norepinephrine | 1979 |
Plasma DOPA and growth hormone in parkinsonism: oscillations in symptoms.
Topics: Aged; Carbidopa; Dihydroxyphenylalanine; Female; Growth Hormone; Humans; Levodopa; Male; Middle Aged; Parkinson Disease | 1979 |
CSF studies on the relationship between dopamine and 5-hydroxytryptamine in Parkinsonism and other movement disorders.
Topics: Aged; Athetosis; Carbidopa; Chorea; Dihydroxyphenylalanine; Dopamine; Dystonia Musculorum Deformans; Hepatolenticular Degeneration; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Methoxyhydroxyphenylglycol; Middle Aged; Movement Disorders; Parkinson Disease; Parkinson Disease, Postencephalitic; Serotonin; Tetrabenazine; Torticollis | 1977 |
[Results of determination of plasma methoxydopa in parkinsonian patients with or without dyskinesia induced by L-Dopa].
Topics: Aged; Dihydroxyphenylalanine; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease | 1977 |
[Long-term l-DOPA therapy for parkinsonism and its pathochemical aspect].
Topics: Dihydroxyphenylalanine; Dopamine; Epinephrine; Follow-Up Studies; Humans; Levodopa; Norepinephrine; Parkinson Disease; Time Factors | 1977 |
The effect of low dose carbidopa/levodopa on prolactin and growth hormone concentrations in patients with breast cancer and in benign breast tumours.
Topics: Adult; Aged; Breast Neoplasms; Carbidopa; Dihydroxyphenylalanine; Female; Growth Hormone; Humans; Hydrazines; Levodopa; Middle Aged; Prolactin; Thyroxine; Time Factors | 1978 |
gamma-Glutamyl dopa: a kidney-specific dopamine precursor.
Topics: Animals; Blood Pressure; Dihydroxyphenylalanine; Dopamine; Female; Glutamates; Kidney; Levodopa; Male; Mice; Rats; Regional Blood Flow | 1978 |
[Pathogenesis and treatment of torsion dystonia].
Topics: Carbidopa; Dihydroxyphenylalanine; Dopamine; Dystonia Musculorum Deformans; Epinephrine; Homovanillic Acid; Humans; Hydrazines; Jews; Levodopa; Norepinephrine; Vanilmandelic Acid | 1978 |
On-off response. Clinical and biochemical correlations during oral and intravenous levodopa administration in parkinsonian patients.
Topics: Administration, Oral; Aged; Blood Pressure; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Female; Humans; Hyperkinesis; Infusions, Parenteral; Levodopa; Long-Term Care; Male; Middle Aged; Movement Disorders; Parkinson Disease; Posture; Time Factors | 1975 |
Mammalian tyrosinase. A comparison of tyrosine hydroxylation and melanin formation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Binding Sites; Catechol Oxidase; Dihydroxyphenylalanine; Dopamine; Kinetics; Levodopa; Melanins; Melanocytes; Mice; Monophenol Monooxygenase; Time Factors; Tyrosine | 1976 |
Plasma DOPA levels and growth hormone response to levodopa in parkinsomism.
Topics: Adult; Aged; Dihydroxyphenylalanine; Dyskinesia, Drug-Induced; Female; Growth Hormone; Humans; Levodopa; Male; Middle Aged; Parkinson Disease | 1977 |
Studies on the mechanisms of L-dopa-induced depletion of 5-hydroxytryptamine in the mouse brain.
Topics: Amines; Animals; Benztropine; Biological Transport; Brain; Clomipramine; Cocaine; Dihydroxyphenylalanine; Dopamine; Imipramine; Levodopa; Male; Mice; Mice, Inbred ICR; Serotonin; Tryptophan | 1977 |
Effect of L-DOPA analogues in Sidman avoidance performance in mice.
Topics: Animals; Avoidance Learning; Benserazide; Brain; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Methyldopa; Mice; Motor Activity; Norepinephrine; Serotonin | 1977 |
Preferential deamination of dopamine by an A type monoamine oxidase in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Clorgyline; Corpus Striatum; Deamination; Dihydroxyphenylalanine; Dopamine; Female; Homovanillic Acid; Levodopa; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Motor Activity; Normetanephrine; Phenethylamines; Rats; Reserpine; Serotonin; Tyramine | 1976 |
[Combined treatment of Parkinsonism with L-dopa and peripheral dopa decarboxylase inhibitors--clinical course of 13 cases and levels of serum/dopa and dopamine].
Topics: Adult; Aged; Benserazide; Carbidopa; Dihydroxyphenylalanine; Dopamine; Drug Therapy, Combination; Female; Humans; Hydrazines; Levodopa; Male; Middle Aged; Parkinson Disease | 1976 |
Influence of L-3-methoxytyrosine on monoamine synthesis in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Brain; Dihydroxyphenylalanine; Dopamine; Hydrazines; Hydroxyindoleacetic Acid; Levodopa; Liver; Male; Myocardium; Norepinephrine; Rats; Serotonin; Tryptophan; Tyrosine | 1975 |
Human growth hormone response to levodopa. Relation to menopause, depression, and plasma dopa concentration.
Topics: Adult; Age Factors; Aged; Depression; Dihydroxyphenylalanine; Female; Growth Hormone; Humans; Levodopa; Male; Menopause; Middle Aged; Pituitary Gland; Sex Factors | 1975 |
[Progress in the therapy of parkinsonism with L-dopa: inhibition of dopa decarboxylase].
Topics: Adrenal Glands; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Guinea Pigs; Intestinal Mucosa; Kidney; Levodopa; Liver; Myocardium; Parkinson Disease; Rabbits; Rats; Spleen | 1975 |
Type I cells of carotid body from rats treated with 5-OH-dopa and L-dopa: an electron microscopical study.
Topics: Animals; Carotid Body; Cell Count; Cell Nucleus; Dihydroxyphenylalanine; Levodopa; Male; Microscopy, Electron; Mitochondria; Rats | 1975 |
Fluorescence reactions of fluorescamine with levodopa and its derivatives: fluorescence assay of 3-methoxy-4-hydroxyphenylalanine in levodopa dosage forms.
Topics: Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Dopamine; Fluorescamine; Fluorescence; Levodopa; Oxidation-Reduction; Phenylalanine; Spectrophotometry, Ultraviolet; Spiro Compounds | 1975 |
[Alkaloids in human tissue. Base catalysed epimerization of derivatives from condensation products of L- and D-dopa with acetaldehyde].
Topics: Acetaldehyde; Catalysis; Dihydroxyphenylalanine; Humans; Isoquinolines; Levodopa | 1975 |
Sequential analysis: manganese, catecholamines and L-dopa induced dyskinesia.
Topics: Animals; Brain Chemistry; Cats; Caudate Nucleus; Cerebral Cortex; Corpus Callosum; Dihydroxyphenylalanine; Dopamine; Hypothalamus; Levodopa; Male; Manganese; Methods; Movement Disorders | 1975 |
Patterns of clinical response and plasma dopa levels in Parkinson's disease.
Topics: Adult; Aged; Brain; Carbidopa; Dihydroxyphenylalanine; Disability Evaluation; Dose-Response Relationship, Drug; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Time Factors | 1975 |
Narcotic withdrawal like mouse jumping produced by amphetamine and L-DOPA.
Topics: Amphetamine; Animals; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Fluorometry; Haloperidol; Humans; Levodopa; Male; Mice; Motor Activity; Norepinephrine; Phentolamine; Pimozide; Substance Withdrawal Syndrome | 1975 |
Normalization of brain serotonin by L-tryptophan in levodopa-treated rats.
Topics: Animals; Behavior, Animal; Brain; Dihydroxyphenylalanine; Dopamine; Drug Interactions; Drug Therapy, Combination; Homovanillic Acid; Levodopa; Male; Rats; Serotonin; Tryptophan | 1975 |
Responsibility of extrastriatal areas for the appearance of psychotic symptoms (clinical and biochemical human post-mortem findings).
Topics: Brain; Brain Mapping; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Parkinson Disease; Psychoses, Substance-Induced | 1975 |
Modification of the actions of some neuroactive drugs by growth hormone.
Topics: Animals; Apomorphine; Behavior, Animal; Dihydroxyphenylalanine; Dopamine; Drug Synergism; Growth Hormone; Levodopa; Male; Mice; Oxotremorine; Parkinson Disease; Psychotropic Drugs; Tyrosine | 1976 |
Long-term treatment response and fluorodopa positron emission tomographic scanning of parkinsonism in a family with dopa-responsive dystonia.
Topics: Adult; Aged; Brain; Child; Child, Preschool; Dihydroxyphenylalanine; Dystonia; Family; Female; Fluorine Radioisotopes; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Pedigree; Tomography, Emission-Computed | 1992 |
Hereditary progressive dystonia with diurnal fluctuation (Segawa's syndrome)--an unusual case.
Topics: Body Weight; Child; Chromosomes, Human, Pair 9; Circadian Rhythm; Dihydroxyphenylalanine; Dystonia; Female; Humans; Levodopa; Muscle Tonus; Neurologic Examination | 1992 |
Evidence for L-dopa systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat.
Topics: Animals; Blood Pressure; Calcium; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Heart Rate; Levodopa; Male; Medulla Oblongata; Norepinephrine; Rats; Rats, Inbred Strains | 1992 |
Antagonism of U-50,488H-induced antinociception by ginseng total saponins is dependent on serotonergic mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dihydroxyphenylalanine; Levodopa; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Panax; Plants, Medicinal; Pyrrolidines; Reaction Time; Saponins; Serotonin | 1992 |
High-performance liquid chromatography with electrochemical detection for the determination of levodopa, catecholamines and their metabolites in rat brain dialysates.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Caudate Nucleus; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Epinephrine; Homovanillic Acid; Injections, Intraperitoneal; Levodopa; Male; Methyldopa; Norepinephrine; Rats; Rats, Inbred Strains; Substantia Nigra | 1992 |
Effect of different isomers of dihydroxybenzoic acids (DBA) on the rate of DL-dopa oxidation by mushroom tyrosinase.
Topics: Basidiomycota; Dihydroxyphenylalanine; Drug Synergism; Gentisates; Hydroxybenzoates; Isomerism; Kinetics; Levodopa; Models, Chemical; Monophenol Monooxygenase; Oxidation-Reduction; Plant Proteins; Structure-Activity Relationship | 1992 |
Metabolism of 5-fluoro-dopa and 6-fluoro-dopa enantiomers in aggregating cell cultures of fetal rat brain.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Cells, Cultured; Dihydroxyphenylalanine; Female; Fetus; Levodopa; Rats; Rats, Inbred Strains; Stereoisomerism; Time Factors | 1992 |
Isolated tremor and disruption of the nigrostriatal dopaminergic system: an 18F-dopa PET study.
Topics: Adult; Aged; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Fluorine Radioisotopes; Humans; Levodopa; Middle Aged; Parkinson Disease; Posture; Reference Values; Substantia Nigra; Tomography, Emission-Computed; Tremor | 1992 |
Comparative metabolism of fluorinated 3,4-dihydroxyphenylalanine isomers in aggregating brain cell cultures.
Topics: Animals; Brain; Cell Aggregation; Cells, Cultured; Decarboxylation; Dihydroxyphenylalanine; Levodopa; Methylation; Stereoisomerism | 1992 |
Disposition of gamma-glutamyl levodopa (gludopa) after intravenous bolus injection in healthy volunteers.
Topics: Adult; Dihydroxyphenylalanine; Dopamine; Humans; Injections, Intravenous; Levodopa; Male; Metabolic Clearance Rate | 1991 |
Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseases.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chick Embryo; Dibenzocycloheptenes; Dihydroxyphenylalanine; Dizocilpine Maleate; Hippocampus; Huntington Disease; Levodopa; Neurons; Parkinson Disease; Quinoxalines; Receptors, Neurotransmitter; Retina | 1990 |
Pharmacokinetics, bioavailability, metabolism, tissue distribution and urinary excretion of gamma-L-glutamyl-L-dopa in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biological Availability; Dihydroxyphenylalanine; Dopamine; Female; Humans; Kidney; Levodopa; Liver; Middle Aged; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Effect of amperozide on the synthesis and turnover of monoamines in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; alpha-Methyltyrosine; Animals; Biogenic Monoamines; Brain Chemistry; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Levodopa; Male; Methyltyrosines; Norepinephrine; Piperazines; Psychotropic Drugs; Rats; Rats, Inbred Strains; Serotonin | 1990 |
Comparative in vivo metabolism of 6-[18F]fluoro-L-dopa and [3H]L-dopa in rats.
Topics: Animals; Brain; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Fluorine Radioisotopes; Injections, Intravenous; Kinetics; Levodopa; Male; Rats; Rats, Inbred Strains; Tritium | 1990 |
Renal dopamine synthesis from precursors.
Topics: Animals; Dihydroxyphenylalanine; Dopamine; In Vitro Techniques; Kidney; Levodopa; Male; Perfusion; Prodrugs; Rats; Rats, Inbred Strains | 1990 |
Method for the determination of gamma-L-glutamyl-L-dihydroxyphenylalanine and its major metabolites L-dihydroxyphenylalanine, dopamine and 3,4-dihydroxyphenylacetic acid by high-performance liquid chromatography with electrochemical detection.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Humans; Kidney; Levodopa; Liver; Phenylacetates; Rats | 1990 |
Cognitive deficiency induced by the acute stress in rats: a possible role of brain catecholaminergic systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain Chemistry; Cognition Disorders; Dihydroxyphenylalanine; Escape Reaction; Exploratory Behavior; Levodopa; Male; Norepinephrine; Rats; Stress, Physiological | 1990 |
The effect of benserazide on the peripheral and central distribution and metabolism of levodopa after acute and chronic administration in the rat.
Topics: Animals; Benserazide; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Electrochemistry; Half-Life; Injections, Intraperitoneal; Levodopa; Male; Rats | 1990 |
Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-dopa in the rat.
Topics: Amidines; Animals; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Electrochemistry; Female; Homovanillic Acid; Levodopa; Pyridones; Rats; Rats, Inbred Strains; Tyrosine | 1990 |
Rat brain concentration of administered amino acids: dependence on time of day for administration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Animals; Brain Chemistry; Dihydroxyphenylalanine; Drug Administration Schedule; Hydroxyindoleacetic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Serotonin; Time Factors; Tryptophan | 1986 |
Relationship between receptor occupancy and response at striatal dopamine autoreceptors.
Topics: 4-Butyrolactone; Adrenergic alpha-Antagonists; Animals; Apomorphine; Corpus Striatum; Dihydroxyphenylalanine; Homeostasis; Hydrazines; Levodopa; Male; Piperidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1987 |
Nicotinic acid or N-methyl nicotinamide prolongs elevated brain dopa and dopamine in L-dopa treatment.
Topics: Animals; Benserazide; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Levodopa; Liver; Male; Niacinamide; Nicotinic Acids; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 1986 |
Pharmacokinetics of L-dopa in patients with Parkinson's disease.
Topics: Biotransformation; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disability Evaluation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Kinetics; Levodopa; Methyldopa; Parkinson Disease; Receptors, Dopamine; Receptors, Dopamine D2; Tiapamil Hydrochloride | 1987 |
Effect of supplemental carbidopa on bioavailability of L-dopa.
Topics: Aged; Biological Availability; Carbidopa; Dihydroxyphenylalanine; Drug Administration Schedule; Humans; Levodopa; Parkinson Disease | 1986 |
Delayed onset of responses to single doses of L-dopa in parkinsonian fluctuators on long-term L-dopa therapy.
Topics: Aged; Dihydroxyphenylalanine; Drug Administration Schedule; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Reaction Time; Retrospective Studies; Time Factors | 1986 |
High yield synthesis of 6-[18F]fluoro-L-dopa.
Topics: Arsenic; Arsenicals; Boranes; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Fluorides; Fluorine; Isomerism; Isotope Labeling; Levodopa; Radioisotopes; Silanes; Silicon Compounds; Solvents | 1986 |
Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography.
Topics: Adult; Aged; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tomography, Emission-Computed | 1986 |
Biochemical monitoring of children with neuroblastoma.
Topics: Aminoisobutyric Acids; Child; Cystathionine; Dihydroxyphenylalanine; Homovanillic Acid; Humans; Levodopa; Monitoring, Physiologic; Neuroblastoma; Norepinephrine; Prognosis | 1986 |
Inhibition of monoamine oxidase by 3,4-dihydroxyphenyl L-alanine and its analogues.
Topics: Dihydroxyphenylalanine; Droxidopa; Humans; In Vitro Techniques; Kynuramine; Levodopa; Methyldopa; Mitochondria; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Placenta; Stereoisomerism; Structure-Activity Relationship | 1987 |
Cerebral metabolism of 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine in the primate.
Topics: Animals; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Frontal Lobe; Kinetics; Levodopa; Macaca mulatta; Male; Occipital Lobe | 1987 |
Positron emission tomography in Parkinson's disease: glucose and DOPA metabolism.
Topics: Adult; Aged; Blood Glucose; Brain; Caudate Nucleus; Cerebellum; Deoxyglucose; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Humans; Levodopa; Middle Aged; Parkinson Disease; Putamen; Tomography, Emission-Computed | 1987 |
[Long-term problems of levodopa therapy in Parkinson disease].
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dyskinesia, Drug-Induced; Humans; Levodopa; Life Expectancy; Parkinson Disease; Time Factors | 1987 |
Increase of catecholamines in mouse brain by systemic administration of gamma-glutamyl L-3,4-dihydroxyphenylalanine.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Brain; Catecholamines; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Levodopa; Mice; Norepinephrine; Time Factors | 1987 |
[Use of L-DOPA in the complex treatment of severe craniocerebral injuries].
Topics: Adolescent; Adult; Brain Injuries; Child; Combined Modality Therapy; Dihydroxyphenylalanine; Dopamine; Epinephrine; Follow-Up Studies; Humans; Levodopa; Middle Aged; Norepinephrine; Syndrome | 1987 |
Inhibition of decarboxylase and levels of dopa and 3-O-methyldopa: a comparative study of benserazide versus carbidopa in rodents and of Madopar standard versus Madopar HBS in volunteers.
Topics: Administration, Oral; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Brain; Carbidopa; Delayed-Action Preparations; Dihydroxyphenylalanine; Dogs; Dopa Decarboxylase; Dose-Response Relationship, Drug; Drug Combinations; Humans; Hydrazines; Kidney; Levodopa; Liver; Male; Mice; Rats; Time Factors; Tyrosine | 1987 |
Limited tryptic proteolysis of pig kidney 3,4-dihydroxyphenylalanine decarboxylase.
Topics: 5-Hydroxytryptophan; Amino Acid Sequence; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Binding Sites; Dihydroxyphenylalanine; Dopa Decarboxylase; Electrophoresis, Polyacrylamide Gel; Immunosorbent Techniques; Kidney; Levodopa; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Protein Conformation; Pyridoxal Phosphate; Spectrophotometry; Swine; Trypsin | 1988 |
Effect of acute ethanol administration on brain levels of tetrahydropapaveroline in L-dopa-treated rats.
Topics: Animals; Brain; Dihydroxyphenylalanine; Dopamine; Ethanol; Injections, Intraperitoneal; Levodopa; Male; Papaverine; Rats; Rats, Inbred Strains; Tetrahydropapaveroline; Time Factors | 1987 |
Erratic gastric emptying of levodopa may cause "random" fluctuations of parkinsonian mobility.
Topics: Absorption; Administration, Oral; Dihydroxyphenylalanine; Duodenum; Gastric Emptying; Humans; Intubation; Levodopa; Male; Middle Aged; Nose; Parkinson Disease | 1988 |
D-dopa and L-dopa similarly elevate brain dopamine and produce turning behavior in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Carbidopa; Cerebral Ventricles; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Stereotyped Behavior; Structure-Activity Relationship | 1988 |
Ultraweak photon emission in model reactions of the in vitro formation of eumelanins and pheomelanins.
Topics: Catechol Oxidase; Chemical Phenomena; Chemistry; Cysteine; Cysteinyldopa; Dihydroxyphenylalanine; Isomerism; Kinetics; Levodopa; Luminescent Measurements; Melanins; Monophenol Monooxygenase; Oxidation-Reduction; Peroxidases | 1987 |
[Effect of the test with the drug Nakom on the dynamics of excretion of catecholamines and DOPA in children with Duchenne's progressive muscular dystrophy].
Topics: Adolescent; Carbidopa; Catecholamines; Child; Child, Preschool; Circadian Rhythm; Dihydroxyphenylalanine; Drug Combinations; Humans; Levodopa; Muscular Dystrophies | 1985 |
Evidence that D-1 dopamine receptors contribute to the supersensitive behavioral responses induced by L-dihydroxyphenylalanine in rats treated neonatally with 6-hydroxydopamine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Benzazepines; Dihydroxyphenylalanine; Drug Interactions; Ergolines; Female; Flupenthixol; Haloperidol; Hydroxydopamines; Levodopa; Male; Motor Activity; Oxidopamine; Pregnancy; Quinpirole; Rats; Receptors, Dopamine; Self Mutilation; Stereotyped Behavior | 1985 |
The effect of L-DOPA on brain polysomes and protein synthesis: probable mediation by intracellular dopamine.
Topics: 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Carbon Radioisotopes; Decarboxylation; Depression, Chemical; Dihydroxyphenylalanine; Dopamine; Drug Interactions; Enzyme Inhibitors; Hydrazines; Leucine; Levodopa; Lysine; Male; Methyldopa; Nerve Tissue Proteins; Norepinephrine; Polyribosomes; Rats; S-Adenosylmethionine; Time Factors | 1974 |
Some anomalies in the L-DOPA response: recent biochemical studies.
Topics: Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Models, Biological; Papaverine; Parkinson Disease | 1974 |
Inhibition of DOPA accumulation by rat brain at critical L-DOPA circulating concentrations.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Drug Interactions; Enzyme Inhibitors; Levodopa; Male; Mice; Myocardium; Rats | 1974 |
Dopamine receptor in the reward system of the rat.
Topics: Amantadine; Animals; Apomorphine; Benzyl Compounds; Cortical Synchronization; Desipramine; Dihydroxyphenylalanine; Dopamine; Electrodes, Implanted; Electroencephalography; Haloperidol; Hydrazines; Hypothalamus; Levodopa; Male; Rats; Receptors, Drug; Reward; Self Stimulation; Time Factors | 1974 |
Variations in L-dopa absorption. Report of a parkinsonian patient with high plasma dopa concentration after therapeutical L-dopa dose.
Topics: Administration, Oral; Aged; Carbon Radioisotopes; Decarboxylation; Dihydroxyphenylalanine; Dopamine; Female; Humans; Injections, Intravenous; Levodopa; Male; Middle Aged; Parkinson Disease; Phenylalanine; Stimulation, Chemical; Sulfates; Tyrosine | 1974 |
Relationship between the "late reflex discharge" and locomotor movements in acute spinal cats and rabbits treated with DOPA.
Topics: Animals; Cats; Dihydroxyphenylalanine; Laminectomy; Levodopa; Locomotion; Motor Neurons; Nialamide; Rabbits; Reflex; Spinal Cord | 1974 |
Plasma dopa concentrations and the "on-off" effect after chronic treatment of Parkinson's disease.
Topics: Dietary Proteins; Dihydroxyphenylalanine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Movement Disorders; Parkinson Disease | 1974 |
Treatment of Parkinson's disease with carbidopa, a peripheral decarboxylase inhibitor, and levodopa.
Topics: Aged; Carbidopa; Carboxy-Lyases; Dihydroxyphenylalanine; Drug Therapy, Combination; Female; Humans; Hydrazines; Levodopa; Male; Middle Aged; Parkinson Disease | 1974 |
Transneuronal regulation of tyrosine hydroxylase expression in olfactory bulb of mouse and rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Afferent Pathways; Animals; Benserazide; Dihydroxyphenylalanine; Dopamine; Female; Levodopa; Mice; Mice, Inbred Strains; Neurons; Norepinephrine; Olfactory Bulb; Rats; Rats, Inbred Strains; Reserpine; Species Specificity; Tyrosine 3-Monooxygenase | 1983 |
Enzymatic 5-hydroxylation of L-dopa by a tyrosinase isolated from the sea anemone Metridium senile.
Topics: Animals; Catalysis; Catechol Oxidase; Cnidaria; Dihydroxyphenylalanine; Hydroxylation; Levodopa; Mixed Function Oxygenases; Monophenol Monooxygenase; Sea Anemones; Substrate Specificity; Tyrosine 3-Monooxygenase | 1984 |
Intermittent levodopa therapy in parkinsonism.
Topics: Aged; Biomechanical Phenomena; Corpus Striatum; Decarboxylation; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease | 1983 |
The mechanism of toxicity of 5-S-cysteinyldopa to tumour cells. Hydrogen peroxide as a mediator of cytotoxicity.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cysteinyldopa; Dihydroxyphenylalanine; Dopamine; Humans; Hydrogen Peroxide; Levodopa; Male; Mice; Neoplasms, Experimental; Neuroblastoma; Oxidation-Reduction | 1983 |
[Reactivity of the DOPA--dopamine--noradrenaline--adrenaline system in epileptics].
Topics: Adolescent; Adult; Catecholamines; Dihydroxyphenylalanine; Dopamine; Epilepsies, Partial; Epilepsy; Epinephrine; Female; Humans; Insulin; Levodopa; Male; Middle Aged; Norepinephrine | 1983 |
Synthesis of no-carrier-added L- and D-[1-11C]-DOPA.
Topics: Brain; Dihydroxyphenylalanine; Humans; Isotope Labeling; Levodopa; Neoplasms; Radionuclide Imaging | 1983 |
A personal and scientific biography of Dr. George C. Cotzias.
Topics: Brain Chemistry; Dihydroxyphenylalanine; Dopamine; History, 20th Century; Humans; Levodopa; Manganese Poisoning; Parkinson Disease; Trace Elements | 1984 |
"On-off" phenomenon in Parkinson's disease: correlation to the concentration of dopa in plasma.
Topics: Aged; Amino Acids; Blood-Brain Barrier; Brain; Dihydroxyphenylalanine; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease, Secondary; Receptors, Dopamine | 1984 |
Aromatic radiofluorination with [18F]fluorine gas: 6-[18F]fluoro-L-dopa.
Topics: Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Fluorine; Isotope Labeling; Levodopa; Magnetic Resonance Spectroscopy; Radioisotopes | 1984 |
Activation of dopamine synthesis in mesolimbic dopamine neurons by immobilization stress in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Haloperidol; Humans; Levodopa; Limbic System; Male; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Psychological | 1984 |
Simultaneous determination of L-dopa and 3-O-methyldopa in human serum by high-performance liquid chromatography.
Topics: Adult; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Epinephrine; Humans; Levodopa; Male; Methyltyrosines; Norepinephrine; Parkinson Disease; Tyrosine | 1984 |
[Mechanisms of local anesthetic-induced convulsions. The relation to brain catecholamines].
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catecholamines; Dihydroxyphenylalanine; Levodopa; Lidocaine; Male; Mice; Mice, Inbred Strains; Norepinephrine; Pentylenetetrazole; Seizures | 1984 |
Selective toxicity of 5-S-cysteinyldopa, a melanin precursor, to tumor cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line; Cysteinyldopa; Dihydroxyphenylalanine; DNA; Dose-Response Relationship, Drug; Female; Humans; Leukemia L1210; Levodopa; Male; Melanins; Mice; Neoplasm Transplantation; Prognosis; Protein Biosynthesis; Transplantation, Heterologous | 1980 |
Effects of lithium on behaviour and central monoamines.
Topics: Amphetamine; Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Brain; Catecholamines; Clonidine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Interactions; Levodopa; Lithium; Locomotion; Mice; Motor Activity; Rats | 1980 |
Distribution and metabolism of tritiumlabelled 5-S-cysteinyldopa in mice.
Topics: Animals; Cysteinyldopa; Dihydroxyphenylalanine; Levodopa; Male; Melanoma; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Tissue Distribution | 1980 |
Chronic L-DOPA treatment of mice: a behavioural and biochemical study.
Topics: Animals; Apomorphine; Benserazide; Body Temperature Regulation; Brain; Clonidine; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Male; Mice; Motor Activity; Norepinephrine; Substance Withdrawal Syndrome | 1981 |
[Biochemical evaluation of the effectiveness of antiparkinson preparations containing L-DOPA].
Topics: Carbidopa; Dihydroxyphenylalanine; Dopamine; Drug Combinations; Epinephrine; Humans; Levodopa; Norepinephrine; Parkinson Disease | 1981 |
A semiautomated method for the rapid determination of dopa: comparison of plasma and erythrocyte-dopa concentration in levodopa-treated patients.
Topics: Autoanalysis; Dihydroxyphenylalanine; Erythrocytes; Humans; Levodopa; Methyltyrosines; Parkinson Disease; Spectrometry, Fluorescence; Tyrosine | 1982 |
[Treatment of Parkinson disease].
Topics: Amantadine; Dihydroxyphenylalanine; Drug Therapy, Combination; Ergot Alkaloids; Humans; Levodopa; Parkinson Disease | 1982 |
Irreversible inhibition of aromatic-L-amino acid decarboxylase by alpha-difluoromethyl-DOPA and metabolism of the inhibitor.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Catechol O-Methyltransferase; Dihydroxyphenylalanine; Kidney; Levodopa; Methylation; Methyldopa; Pyridoxal Phosphate; Rats; Swine | 1980 |
Mesencephalic grafts partially restore normal nigral dynorphin levels in 6-hydroxydopamine-lesioned rats treated chronically with L-dihydroxyphenylalanine.
Topics: Amphetamine; Animals; Apomorphine; Brain Tissue Transplantation; Dihydroxyphenylalanine; Dopamine Agents; Dopamine Agonists; Dynorphins; Female; Fetal Tissue Transplantation; Image Processing, Computer-Assisted; Levodopa; Oxidopamine; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 1995 |
CSF and plasma concentrations of free norepinephrine, dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), 3,4-dihydroxyphenylalanine (DOPA), and epinephrine in Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Humans; Levodopa; Lumbosacral Region; Male; Middle Aged; Norepinephrine; Parkinson Disease; Severity of Illness Index | 1995 |
Improved tyrosinase activity stains in polyacrylamide electrophoresis gels.
Topics: Animals; Benzoquinones; Dihydroxyphenylalanine; Electrophoresis, Polyacrylamide Gel; Levodopa; Melanocytes; Melanoma, Experimental; Mercaptoethanol; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Neoplasm Transplantation; Staining and Labeling; Tumor Cells, Cultured | 1993 |
Rapid degradation of 3,4-dihydroxyphenylalanine in plasma samples containing ethylenediaminetetraacetic acid.
Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Blood Specimen Collection; Carbidopa; Chelating Agents; Dihydroxyphenylalanine; Dopamine Agents; Edetic Acid; Humans; Levodopa; Temperature | 1995 |
Remission in dihydroxyphenylalanine-responsive dystonia.
Topics: Child; Dihydroxyphenylalanine; Dystonia; Humans; Levodopa; Male; Movement Disorders; Treatment Outcome | 1995 |
Beneficial effects of co-administration of catechol-O-methyltransferase inhibitors and L-dihydroxyphenylalanine in rat models of depression.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Depression; Desipramine; Dihydroxyphenylalanine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Levodopa; Male; Motor Activity; Nitriles; Nitrophenols; Rats; Rats, Wistar; Swimming; Tolcapone | 1995 |
Measurement of dopa and immunolocalization of L-dopa-positive nerve fibers in rat dental pulp.
Topics: Animals; Dental Pulp; Dihydroxyphenylalanine; Immunohistochemistry; Levodopa; Male; Nerve Fibers; Rats; Rats, Sprague-Dawley | 1994 |
PET studies of the presynaptic and postsynaptic dopaminergic system in Tourette's syndrome.
Topics: Adolescent; Adult; Antipsychotic Agents; Carbon Radioisotopes; Case-Control Studies; Caudate Nucleus; Dihydroxyphenylalanine; Dopamine D2 Receptor Antagonists; Female; Fluorine Radioisotopes; Humans; Levodopa; Male; Matched-Pair Analysis; Middle Aged; Presynaptic Terminals; Putamen; Raclopride; Receptors, Dopamine; Salicylamides; Tomography, Emission-Computed; Tourette Syndrome | 1994 |
Sympatho-inhibitory effects of r-l-glutamyl-l-dopa in conscious rabbits.
Topics: Animals; Dihydroxyphenylalanine; Dopamine; Heart Rate; Kidney; Levodopa; Male; Norepinephrine; Prodrugs; Rabbits | 1994 |
Regional haemodynamic effects of dopamine and its prodrugs L-dopa and gludopa in the rat and in the glycerol-treated rat as a model for acute renal failure.
Topics: Acute Kidney Injury; Animals; Dihydroxyphenylalanine; Dopamine; Glycerol; Hemodynamics; Kidney; Levodopa; Male; Rats; Rats, Wistar; Renal Circulation | 1994 |
Suppression of dyskinesias in advanced Parkinson's disease. II. Increasing daily clozapine doses suppress dyskinesias and improve parkinsonism symptoms.
Topics: Aged; Clozapine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease | 1993 |
Rest tremor and extrapyramidal symptoms after midbrain haemorrhage: clinical and 18F-dopa PET evaluation.
Topics: Adult; Basal Ganglia Diseases; Dihydroxyphenylalanine; Electromyography; Fluorine Radioisotopes; Humans; Intracranial Arteriovenous Malformations; Levodopa; Male; Mesencephalon; Posture; Rest; Rupture, Spontaneous; Subarachnoid Hemorrhage; Thalamus; Tomography, Emission-Computed; Tremor | 1994 |
The renal handling of dopamine originating from L-dopa and gamma-glutamyl-L-dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Electrochemistry; In Vitro Techniques; Kidney; Levodopa; Male; Rats; Rats, Wistar | 1994 |
Endogenously released DOPA is probably relevant to nicotine-induced increases in locomotor activities of rats.
Topics: alpha-Methyltyrosine; Animals; Corpus Striatum; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Injections, Intraventricular; Levodopa; Male; Mecamylamine; Methyltyrosines; Motor Activity; Nerve Fibers; Nicotine; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tyrosine 3-Monooxygenase | 1993 |
Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease.
Topics: Brain Tissue Transplantation; Dihydroxyphenylalanine; Dopamine; Fetal Tissue Transplantation; Humans; Levodopa; Mesencephalon; Parkinson Disease; Putamen | 1994 |
Positron emission tomographic studies of dopa-responsive dystonia and early-onset idiopathic parkinsonism.
Topics: Adolescent; Adult; Corpus Striatum; Diagnosis, Differential; Dihydroxyphenylalanine; Dystonia; Female; Fluorine Radioisotopes; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Prognosis; Tomography, Emission-Computed | 1993 |
Transmitter-like L-3,4-dihydroxyphenylalanine tonically functions to mediate vasodepressor control in the caudal ventrolateral medulla of rats.
Topics: Animals; Blood Pressure; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Electrochemistry; Hemodynamics; Levodopa; Male; Medulla Oblongata; Microdialysis; Microinjections; Norepinephrine; Oxidopamine; Rats; Rats, Wistar; Stereotaxic Techniques | 1993 |
Dopaminergic abnormalities in hypertension associated with moderate renal insufficiency.
Topics: 3,4-Dihydroxyphenylacetic Acid; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Diastole; Dihydroxyphenylalanine; Dopamine; Female; Homovanillic Acid; Humans; Hypertension; Kidney Failure, Chronic; Levodopa; Male; Middle Aged; Reference Values; Sodium | 1994 |
The dopamine prodrug, gludopa, decreases both renal and extrarenal noradrenaline spillover in conscious rabbits.
Topics: Animals; Blood Pressure; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Heart Rate; Kidney; Levodopa; Male; Norepinephrine; Rabbits | 1993 |
Administration of the new COMT inhibitor OR-611 increases striatal uptake of fluorodopa.
Topics: Animals; Catechols; Corpus Striatum; Dihydroxyphenylalanine; Fluorine Radioisotopes; Levodopa; Macaca fascicularis; Magnetic Resonance Imaging; Male; Nitriles; Parkinson Disease; Tomography, Emission-Computed | 1993 |
Suppression of dyskinesias in advanced Parkinson's disease. I. Continuous intravenous levodopa shifts dose response for production of dyskinesias but not for relief of parkinsonism in patients with advanced Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Carbidopa; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Infusions, Intravenous; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease; Tyrosine | 1993 |
Comparison of striatal 18F-dopa uptake in adult-onset dystonia-parkinsonism, Parkinson's disease, and dopa-responsive dystonia.
Topics: Adult; Age Factors; Caudate Nucleus; Dihydroxyphenylalanine; Dystonia; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Putamen; Tomography, Emission-Computed | 1993 |
Dopamine formation, from its immediate precursor 3,4-dihydroxyphenylalanine, along the rat digestive tract.
Topics: Animals; Digestive System; Dihydroxyphenylalanine; Dopamine; In Vitro Techniques; Intestinal Mucosa; Jejunum; Levodopa; Male; Norepinephrine; Rats; Rats, Wistar | 1993 |
Repeated L-dopa administration reduces the ability of dopamine storage and abolishes the supersensitivity of dopamine receptors in the striatum of intact rat.
Topics: Animals; Base Sequence; Blotting, Northern; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Molecular Sequence Data; Oligonucleotide Probes; Rats; Rats, Wistar; Receptors, Dopamine; RNA, Messenger; Time Factors | 1993 |
6-[18F]fluoro-L-dopa metabolism in living human brain: a comparison of six analytical methods.
Topics: Adult; Caudate Nucleus; Dihydroxyphenylalanine; Fluorine Radioisotopes; Humans; Levodopa; Middle Aged; Models, Biological; Parkinson Disease; Putamen; Tomography, Emission-Computed | 1993 |
Clinical heterogeneity of dopa-responsive dystonia: PET observations.
Topics: Adult; Aged; Corpus Striatum; Diagnosis, Differential; Dihydroxyphenylalanine; Dystonia; Female; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Parkinson Disease, Secondary; Receptors, Dopamine; Tomography, Emission-Computed | 1993 |
PET scan study on the dopaminergic system in a Japanese patient with hereditary progressive dystonia (Segawa's disease). Case report.
Topics: Corpus Striatum; Dihydroxyphenylalanine; Dystonia; Female; Humans; Japan; Levodopa; Middle Aged; Neurologic Examination; Parkinson Disease; Parkinson Disease, Secondary; Tomography, Emission-Computed | 1993 |
Defective 3,4-dihydroxyphenylalanine decarboxylation to dopamine in hydralazine-treated hypertensive patients may be pyridoxine remediable.
Topics: Adult; Cardiovascular System; Decarboxylation; Dihydroxyphenylalanine; Diuresis; Dopamine; Female; Hormones; Humans; Hydralazine; Hypertension; Kidney; Levodopa; Male; Middle Aged; Pyridoxine; Sodium | 1993 |
Synthesis of polymer-bound 6-mercuric carboxylate DOPA precursors and solid phase labelling method of 6-radioiodinated L-DOPA.
Topics: Dihydroxyphenylalanine; Iodine Radioisotopes; Levodopa; Mercury Compounds; Polymers | 1996 |
New thioureas and related substances intended for melanoma targeting.
Topics: Animals; Autoradiography; Basidiomycota; Benzoquinones; Dihydroxyphenylalanine; Dopamine Agents; Intramolecular Oxidoreductases; Isomerases; Levodopa; Melanins; Melanoma; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Neoplasm Transplantation; Oxidation-Reduction; Thiourea; Whole-Body Irradiation | 1995 |
Elevated striatal dopamine levels following administration of D-DOPA and its alpha-keto acid metabolite DHPPA: behavioral and physiological studies in vivo in the rat.
Topics: Animals; Behavior, Animal; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Levodopa; Male; Microdialysis; Neostriatum; Phenylpyruvic Acids; Rats; Rats, Sprague-Dawley; Stereoisomerism; Stereotyped Behavior; Substantia Nigra | 1996 |
Synthesis and evaluation of radioiodinated 6-iodo-L-DOPA as a cerebral L-amino acid transport marker.
Topics: Amino Acids; Animals; Biological Transport; Brain; Dihydroxyphenylalanine; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Levodopa; Liver; Male; Mice; Mice, Inbred Strains; Ouabain; Pancreas; Pancreatin; Rats; Tissue Distribution; Tomography, Emission-Computed; Tyrosine | 1996 |
[A case of familial juvenile dystonia-parkinsonism: 18F-6-fluorodopa and 18F-fluoro-2-deoxyglucose PET study].
Topics: Adult; Age of Onset; Brain; Deoxyglucose; Dihydroxyphenylalanine; Dystonia; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glucose; Humans; Levodopa; Parkinson Disease; Tomography, Emission-Computed | 1996 |
Flow injection spectrophotometric determination of L-Dopa and carbidopa in pharmaceutical formulations using a crude extract of sweet potato root [Ipomoea batatas (L.) Lam.] as enzymatic source.
Topics: Carbidopa; Dihydroxyphenylalanine; Levodopa; Spectrophotometry; Technology, Pharmaceutical; Vegetables | 1997 |
L-DOPA is a substrate for tyrosine hydroxylase.
Topics: Antioxidants; Basidiomycota; Biopterins; Dihydroxyphenylalanine; Humans; Kinetics; Levodopa; Monophenol Monooxygenase; Recombinant Proteins; Substrate Specificity; Tyrosine 3-Monooxygenase | 1997 |
Effects of chronic levodopa therapy on dopa pharmacokinetics.
Topics: Aged; Antiparkinson Agents; Biological Availability; Dihydroxyphenylalanine; Female; Half-Life; Humans; Levodopa; Long-Term Care; Male; Metabolic Clearance Rate; Middle Aged; Neurologic Examination; Parkinson Disease | 1997 |
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase.
Topics: 3T3 Cells; Animals; Antioxidants; Antiparkinson Agents; Apomorphine; Behavior, Animal; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Fibroblasts; Gene Expression Regulation, Enzymologic; Genetic Therapy; Gliosarcoma; GTP Cyclohydrolase; Humans; Levodopa; Male; Mice; Microdialysis; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Recombinant Fusion Proteins; Retroviridae; Transformation, Genetic; Transgenes; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1998 |
Uptake and intracellular fate of L-DOPA in a human intestinal epithelial cell line: Caco-2.
Topics: Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Biological Transport; Caco-2 Cells; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dihydroxyphenylalanine; Dopamine; Humans; Intestinal Mucosa; Kinetics; Levodopa | 1998 |
PET study and neuropsychological assessment of a long-lasting post-encephalitic parkinsonism.
Topics: Aged; Antiparkinson Agents; Brain; Dihydroxyphenylalanine; Encephalitis, Arbovirus; Female; Fluorine Radioisotopes; Follow-Up Studies; Humans; Levodopa; Memory Disorders; Neuropsychological Tests; Obsessive-Compulsive Disorder; Parkinson Disease; Phobic Disorders; Tomography, Emission-Computed | 1998 |
Pallidotomy improves motor responses and widens the levodopa therapeutic window in Parkinson's disease.
Topics: Administration, Oral; Aged; Antiparkinson Agents; Combined Modality Therapy; Dihydroxyphenylalanine; Dominance, Cerebral; Female; Gait; Globus Pallidus; Humans; Infusions, Intravenous; Levodopa; Male; Middle Aged; Motor Skills; Neurologic Examination; Parkinson Disease; Prolactin; Stereotaxic Techniques | 1998 |
[Is endogenously released DOPA itself an upstream factor for increase in glutamate release and delayed neuronal cell death induced by transient ischemia in rats?].
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Cell Death; Corpus Striatum; Dihydroxyphenylalanine; Glutamic Acid; Hippocampus; Hydrazines; Ischemic Attack, Transient; Levodopa; Male; Rats; Rats, Wistar | 1998 |
gamma-L-glutamyl-L-DOPA inhibits Na(+)-phosphate cotransport across renal brush border membranes and increases renal excretion of phosphate.
Topics: Alanine; Animals; Biological Transport; Calcium; Carrier Proteins; Cyclic AMP; Cyclic GMP; Dihydroxyphenylalanine; Dopamine; gamma-Glutamyltransferase; Kidney Tubules, Proximal; Levodopa; Male; Microvilli; Norepinephrine; Parathyroidectomy; Phosphates; Potassium; Proline; Rats; Sodium; Sodium-Phosphate Cotransporter Proteins; Symporters; Tritium | 1999 |
FluoroDOPA PET shows the nondopaminergic as well as dopaminergic destinations of levodopa.
Topics: Aged; Brain; Dihydroxyphenylalanine; Dopamine; Female; Humans; Kinetics; Levodopa; Male; Middle Aged; Tomography, Emission-Computed | 1999 |
A comparison of 11C-labeled L-DOPA and L-fluorodopa as positron emission tomography tracers for the presynaptic dopaminergic system.
Topics: Animals; Antiparkinson Agents; Benzophenones; Carbon Radioisotopes; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Fluorine Radioisotopes; Levodopa; Macaca mulatta; Nitrophenols; Presynaptic Terminals; Tolcapone; Tomography, Emission-Computed | 1999 |
Striatal D2 dopamine receptor status in Parkinson's disease: an [18F]dopa and [11C]raclopride PET study.
Topics: Adult; Aged; Antiparkinson Agents; Brain Mapping; Carbidopa; Carbon Radioisotopes; Corpus Striatum; Dihydroxyphenylalanine; Drug Combinations; Female; Fluorine Radioisotopes; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Raclopride; Receptors, Dopamine D2; Tomography, Emission-Computed | 1999 |
Spatial memory improvement by levodopa in parkinsonian MPTP-treated monkeys.
Topics: Animals; Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine Agents; Fluorine Radioisotopes; Levodopa; Macaca mulatta; Male; Memory; Motor Activity; MPTP Poisoning; Parkinson Disease, Secondary; Psychomotor Performance; Space Perception | 1999 |
[A DOPA antagonist, DOPA cyclohexyl ester inhibits transient brain ischemia-induced release of glutamate and delayed neuronal cell death in striatal and hippocampal region of in vivo rats].
Topics: Animals; Brain Ischemia; Cell Death; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Glutamates; Hippocampus; Levodopa; Male; Microdialysis; Rats; Rats, Wistar | 1999 |
Effect of gamma-L-glutamyl-L-dopa on phosphate excretion.
Topics: Animals; Benzazepines; Blood Pressure; Dihydroxyphenylalanine; Dipeptides; Dopamine Antagonists; Glomerular Filtration Rate; Injections, Intravenous; Kidney; Levodopa; Male; Phosphates; Rats; Rats, Sprague-Dawley | 2000 |
Putaminal necrosis presenting with hemidystonia.
Topics: Antiparkinson Agents; Brain Diseases; Child; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Dystonia; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Levodopa; Magnetic Resonance Imaging; Necrosis; Putamen; Tomography, Emission-Computed; Treatment Outcome | 2000 |
Evidence for impaired presynaptic dopamine function in parkinsonian patients with motor fluctuations.
Topics: Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine; Female; Fluorine Radioisotopes; Humans; Levodopa; Male; Middle Aged; Motor Neurons; Movement Disorders; Parkinson Disease; Presynaptic Terminals; Substantia Nigra; Tomography, Emission-Computed | 2000 |
The central aromatic amino acid DOPA decarboxylase inhibitor, NSD-1015, does not inhibit L-DOPA-induced circling in unilateral 6-OHDA-lesioned-rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Biogenic Monoamines; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Dopamine Antagonists; Drug Combinations; Enzyme Inhibitors; Haloperidol; Homovanillic Acid; Hydrazines; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Rats; Rats, Wistar; Stereotyped Behavior; Tyrosine | 2001 |
Proteasomal function is impaired in substantia nigra in Parkinson's disease.
Topics: Acetylcysteine; Aged; Cysteine Endopeptidases; Dihydroxyphenylalanine; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Hydrolysis; Levodopa; Lewy Bodies; Male; Multienzyme Complexes; Parkinson Disease; Peptide Hydrolases; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Substantia Nigra; Ubiquitins | 2001 |
Endogenously released DOPA is a causal factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rat striata.
Topics: Animals; Cell Death; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Enzyme Inhibitors; Glutamic Acid; Hydrazines; Ischemic Attack, Transient; Levodopa; Male; Neurons; Rats; Rats, Wistar; Time Factors | 2001 |
DOPA cyclohexyl ester, a competitive DOPA antagonist, protects glutamate release and resultant delayed neuron death by transient ischemia in hippocampus CA1 of conscious rats.
Topics: Animals; Brain Ischemia; Cell Death; Dihydroxyphenylalanine; Glutamic Acid; Hippocampus; Levodopa; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Reperfusion Injury | 2001 |
Detection of response to COMT inhibition in FDOPA PET in advanced Parkinson's disease requires prolonged imaging.
Topics: Aged; Antiparkinson Agents; Brain; Catechol O-Methyltransferase; Catechols; Dihydroxyphenylalanine; Female; Humans; Levodopa; Male; Middle Aged; Movement; Nitriles; Parkinson Disease; Time Factors; Tomography, Emission-Computed | 2001 |
SCH 23390 enhances exogenous L-DOPA decarboxylation in nigrostriatal neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Benzazepines; Corpus Striatum; Decarboxylation; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Dopamine Antagonists; Levodopa; Male; Mice; Substantia Nigra | 2000 |
Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum.
Topics: Adrenergic Agents; Animals; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Extracellular Space; Fluoxetine; Levodopa; Male; Parkinson Disease; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors | 2001 |
Plasma homocysteine and l-dopa metabolism in patients with Parkinson disease.
Topics: Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 2001 |
BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetophenones; Animals; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Methylation; Rats; Rats, Wistar; Time Factors; Tyrosine | 2001 |
The long-term response to levodopa in dopa-responsive dystonia.
Topics: Adolescent; Adult; Aged; Dihydroxyphenylalanine; Dopamine Agents; Dystonia; Female; Humans; Levodopa; Male; Middle Aged; Retrospective Studies; Time Factors; Walking | 2001 |
A splice mutation in the GTP cyclohydrolase I gene causes dopa-responsive dystonia by exon skipping.
Topics: Alleles; Amino Acid Sequence; Aromatic Amino Acid Decarboxylase Inhibitors; Base Sequence; Benserazide; Biopterins; Cells, Cultured; Child, Preschool; Dihydroxyphenylalanine; Drug Combinations; Dystonia; Enzyme Inhibitors; Exons; Female; Fibroblasts; GTP Cyclohydrolase; Humans; Introns; Levodopa; Male; Mutation; Neopterin; RNA Splicing; RNA, Messenger | 2001 |
Blood-brain barrier and neuronal membrane transport of 6-[18F]fluoro-L-DOPA.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Cell Membrane; Dihydroxyphenylalanine; Fluorine Radioisotopes; Levodopa; Male; Models, Animal; Neurons; Rats; Rats, Sprague-Dawley | 2001 |
COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Antiparkinson Agents; Benzophenones; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Disease Progression; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 2002 |
Effect of tetrabenazine on the striatal uptake of exogenous L-DOPA in vivo: a PET study in young and aged rhesus monkeys.
Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Dihydroxyphenylalanine; Dopamine Agents; Image Processing, Computer-Assisted; Levodopa; Macaca mulatta; Magnetic Resonance Imaging; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Neuropeptides; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2002 |
3-OMD and homocysteine plasma levels in parkinsonian patients.
Topics: Dihydroxyphenylalanine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 2002 |
DOPA cyclohexyl ester potently inhibits aglycemia-induced release of glutamate in rat striatal slices.
Topics: Animals; Corpus Striatum; Dihydroxyphenylalanine; Glucose; Glutamic Acid; In Vitro Techniques; Levodopa; Male; Neuroprotective Agents; Rats; Rats, Wistar | 2003 |
Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone).
Topics: Acetophenones; Administration, Oral; Animals; Antiparkinson Agents; Benserazide; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Drug Interactions; Erythrocytes; Humans; In Vitro Techniques; Levodopa; Liver; Methylation; Methyldopa; Microdialysis; Rats; Rats, Wistar | 2003 |
Experimental study on inhibition of neuronal toxical effect of levodopa by ginkgo biloba extract on Parkinson disease in rats.
Topics: Animals; Apoptosis; Dihydroxyphenylalanine; Drug Interactions; Drugs, Chinese Herbal; Ginkgo biloba; Levodopa; Male; Neurons; Oxidopamine; Parkinson Disease; Random Allocation; Rats; Rats, Wistar; Substantia Nigra | 2003 |
Increase in noradrenaline content of tissues after infusion of noradrenaline, dopamine and L-DOPA.
Topics: Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Norepinephrine | 1960 |
Effect of L-DOPA and N-methyl-N-benzyl-2-propynylamine. HC1 on DOPA, dopamine, norepinephrine, epinephrine and serotonin levels in mouse brain.
Topics: Animals; Brain; Brain Chemistry; Catecholamines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Levodopa; Mice; Norepinephrine; Oxidoreductases; Serotonin | 1961 |
[On the effects of L-dopa in man and their modification by reserpine, chlorpromazine, iproniazid and vitamin B6].
Topics: Chlorpromazine; Dihydroxyphenylalanine; Humans; Iproniazid; Levodopa; Male; Reserpine; Vitamin B 6 | 1960 |
[Action of some inhibitors of L-DOPA decarboxylase on the duration of barbiturate narcosis in the mouse].
Topics: Animals; Barbiturates; Cinnamates; Dihydroxyphenylalanine; Dopa Decarboxylase; Hydrazines; Hydroxylamines; Levodopa; Mice; Pentobarbital; Quinolizines; Stupor | 1962 |
[Action of different inhibitors of L-DOPA decarboxylase on the water ration, diuresis and urinary sodium and potassium elimination in rats].
Topics: Animals; Cinnamates; Dihydroxyphenylalanine; Diuresis; Dopa Decarboxylase; Levodopa; Potassium; Rats; Sodium; Thirst; Urinary Tract; Water | 1962 |
Properties of a carrier system to transport L-dopa into brain slices.
Topics: Biological Transport; Cerebral Cortex; Dihydroxyphenylalanine; Levodopa | 1963 |
TEMPORARY AND PARTIAL ANTAGONISM BY L-DOPA OF RESERPINE-INDUCED SUPPRESSION OF A CONDITIONED AVOIDANCE RESPONSE.
Topics: Animals; Avoidance Learning; Conditioning, Psychological; Dihydroxyphenylalanine; Levodopa; Mice; Rats; Research; Reserpine | 1963 |
[EXPERIENCES WITH L-DOPA IN THE THERAPY OF PARKINSONISM].
Topics: Dihydroxyphenylalanine; Humans; Levodopa; Parkinsonian Disorders | 1963 |
INHIBITIONS BY OUABAIN AND PROTOVERATRINE ON ACTIVE TRANSPORT OF L-DOPA INTO BRAIN SLICES.
Topics: Adenine Nucleotides; Animals; Biological Transport, Active; Calcium; Calcium, Dietary; Cerebral Cortex; Cocaine; Dihydroxyphenylalanine; Edetic Acid; Guinea Pigs; Ions; Levodopa; Magnesium; Metabolism; Ouabain; Potassium; Protoveratrines; Research; Sodium; Strophanthins; Veratrum; Veratrum Alkaloids | 1963 |
SUPPRESSION BY POTASSIUM ION ON THE INHIBITORY ACTION OF OUABAIN ON ACTIVE TRANSPORT OF L-DOPA INTO BRAIN SLICES.
Topics: Adenosine Triphosphatases; Animals; Biological Transport, Active; Cerebral Cortex; Dihydroxyphenylalanine; Guinea Pigs; Levodopa; Metabolism; Ouabain; Potassium; Research; Sodium; Sodium, Dietary; Strophanthins; Veratrine | 1963 |
STUDIES ON ACTIVE TRANSPORT OF L-DOPA (DIHYDROXYPHENYLALANINE) INTO BRAIN SLICES.
Topics: Acetates; Alanine; Aniline Compounds; Animals; Biological Transport, Active; Calcium; Calcium, Dietary; Cerebral Cortex; Dihydroxyphenylalanine; Glutamates; Guinea Pigs; Ions; Levodopa; Magnesium; Metabolism; Phenols; Phenylalanine; Research; Sodium; Tyrosine | 1963 |
INCREASE IN ACCUMULATION OF L-DOPA (3,4-DIHYDROXY-PHENYLALANINE) IN BRAIN SLICES BY ALCOHOL.
Topics: Alcohols; Carbon Isotopes; Cerebral Cortex; Dihydroxyphenylalanine; Ethanol; Guinea Pigs; Levodopa; Metabolism; Pharmacology; Phenylalanine; Research | 1963 |
BRAIN AND HEART CATECHOLAMINE LEVELS AFTER L-DOPA ADMINISTRATION IN RESERPINE TREATED MICE: CORRELATIONS WITH A CONDITIONED AVOIDANCE RESPONSE.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain; Conditioning, Psychological; Dihydroxyphenylalanine; Dopamine; Electric Stimulation; Levodopa; Metabolism; Mice; Myocardium; Pharmacology; Research; Reserpine | 1964 |
[THE EFFICACY OF L-DOPA IN PARKINSON PATIENTS WITH AND WITHOUT STEREOTACTIC BRAIN SURGERY].
Topics: Brain; Dihydroxyphenylalanine; Levodopa; Neurosurgery; Neurosurgical Procedures; Parkinsonian Disorders; Psychosurgery; Stereotaxic Techniques | 1964 |
[ON THE CONTROL OF AKINESIA AND OTHER EXTRAPYRAMIDAL MOTOR DISORDERS WITH L-DOPA (L-DIHYDROXYPHENYLALANINE)].
Topics: Chorea; Dihydroxyphenylalanine; Electromyography; Extrapyramidal Tracts; Humans; Levodopa; Monoamine Oxidase Inhibitors; Movement Disorders; Neurosurgery; Neurosurgical Procedures; Parkinsonian Disorders; Stereotaxic Techniques; Torticollis; Tremor | 1964 |
UPTAKE OF L-DOPA AND NORADRENALINE BY CENTRAL CATECHOLAMINE NEURONS.
Topics: Brain Chemistry; Brain Stem; Catecholamines; Dihydroxyphenylalanine; Fluorescence; Histocytochemistry; Hypothalamus; Levodopa; Metabolism; Microscopy; Microscopy, Fluorescence; Neurochemistry; Neurons; Nialamide; Norepinephrine; Pharmacology; Rats; Research; Reserpine; Sympathetic Nervous System | 1964 |
[ELECTROENCEPHALOGRAMS DURING ADMINISTRATION OF L-DOPA BEFORE, IN (DEPTH LEADS AND STIMULATION EFFECTS) AND AFTER STEREOTACTIC BRAIN OPERATIONS IN PARKINSON PATIENTS].
Topics: Brain; Dihydroxyphenylalanine; Electroencephalography; Levodopa; Neurosurgery; Neurosurgical Procedures; Parkinsonian Disorders; Stereotaxic Techniques | 1964 |
[ADDITIONAL EXPERIMENTAL STUDIES ON L-DOPA IN PARKINSON'S SYNDROME AND RESERPINE PARKINSONISM].
Topics: Biomedical Research; Brain; Catecholamines; Dihydroxyphenylalanine; Levodopa; Metabolism; Parkinson Disease; Parkinsonian Disorders; Pharmacology; Reserpine; Toxicology | 1964 |
Anorexigenic activity of L(-) DOPA in animals pretreated with monoaminoxidase inhibitor.
Topics: Animals; Appetite; Dihydroxyphenylalanine; Levodopa; Monoamine Oxidase Inhibitors | 1961 |
Uptake of 6-[18F]fluoro-L-dopa and [18F]CFT reflect nigral neuronal loss in a rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Autoradiography; Behavior, Animal; Brain; Brain Mapping; Central Nervous System Stimulants; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine Agonists; Functional Laterality; Immunohistochemistry; Levodopa; Male; Oxidopamine; Parkinson Disease; Propionates; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2004 |
Time profile of cerebral [18F]6-fluoro-L-DOPA metabolites in nonhuman primate: implications for the kinetics of therapeutic L-DOPA.
Topics: Animals; Dihydroxyphenylalanine; Dopamine Agents; Fluorine Radioisotopes; Levodopa; Macaca nemestrina; Models, Biological; Time Factors | 2004 |
Morphine reward in dopamine-deficient mice.
Topics: Analgesics, Opioid; Animals; Brain; Caffeine; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Levodopa; Mice; Morphine; Motor Activity; Pain; Pain Threshold; Reward; Tail; Tyrosine 3-Monooxygenase | 2005 |
Analogues of N-hydroxycinnamoylphenalkylamides as inhibitors of human melanocyte-tyrosinase.
Topics: Amides; Benzoquinones; Caffeic Acids; Catalysis; Cells, Cultured; Dihydroxyphenylalanine; Enzyme Inhibitors; Humans; Levodopa; Melanins; Melanocytes; Monophenol Monooxygenase; Oxidation-Reduction; Pigmentation Disorders; Pyrones; Skin; Structure-Activity Relationship; Tyramine; Tyrosine | 2006 |
Age-related differences in levodopa dynamics in Parkinson's: implications for motor complications.
Topics: Adult; Age Factors; Age of Onset; Aged; Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine Agents; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tomography, Emission-Computed | 2006 |
Abnormal circuit function in dystonia.
Topics: Brain; Dihydroxyphenylalanine; Dystonia; Humans; Levodopa; Spinal Cord | 2006 |
Long-term 24-hour duodenal infusion of levodopa: outcome and dose requirements.
Topics: Animals; Antiparkinson Agents; Cocaine; Dihydroxyphenylalanine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Duodenum; Humans; Indoles; Infusion Pumps; Levodopa; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Treatment Outcome | 2006 |
D-dopa is unidirectionally converted to L-dopa by D-amino acid oxidase, followed by dopa transaminase.
Topics: Animals; Carbidopa; D-Amino-Acid Oxidase; Dihydroxyphenylalanine; Enzyme Inhibitors; Kidney; Levodopa; Mice; Rats; Rats, Sprague-Dawley; Sodium Benzoate | 2006 |
Imaging the role of dopamine in health and disease Parkinson's disease as a lesion model.
Topics: Antiparkinson Agents; Arousal; Brain; Brain Mapping; Diagnostic Imaging; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Movement; Neuropsychological Tests; Parkinson Disease; Positron-Emission Tomography; Regional Blood Flow; Tomography, Emission-Computed, Single-Photon | 2006 |
Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Dihydroxyphenylalanine; Dopamine Agents; Functional Laterality; Immunohistochemistry; Levodopa; Male; Neuroprotective Agents; Parkinson Disease; Psychomotor Performance; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Triazoles; Tyrosine 3-Monooxygenase; Vibrissae | 2007 |
Compact microelectrode array system: tool for in situ monitoring of drug effects on neurotransmitter release from neural cells.
Topics: Animals; Biosensing Techniques; Collagen; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Electrochemistry; Levodopa; Microarray Analysis; Microelectrodes; Neurons; Neurotransmitter Agents; PC12 Cells; Potassium; Rats; Reproducibility of Results; Sensitivity and Specificity; Time Factors | 2008 |
Autosomal dominant dopa-responsive parkinsonism in a multigenerational Swiss family.
Topics: Adult; Aged; Antiparkinson Agents; Brain; Chromosome Disorders; Dihydroxyphenylalanine; DNA Mutational Analysis; Female; Genes, Dominant; Humans; Levodopa; Male; Middle Aged; Mutation; Parkinson Disease; Pedigree; Phenotype; Positron-Emission Tomography; Radiopharmaceuticals | 2008 |
Development of a new assay for evaluation of l-3,4-dihydroxyphenylalanine cytotoxicity in catalase-mutant Escherichia coli.
Topics: Bacterial Proteins; Biological Assay; Catalase; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Environmental Monitoring; Escherichia coli; Levodopa; Mutation; Oxidative Stress; Reactive Oxygen Species | 2008 |
Alpha1-adrenoceptors mediate dihydroxyphenylalanine-induced activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaques.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic alpha-Antagonists; Animals; Benserazide; Brain Injuries; Dihydroxyphenylalanine; Female; Levodopa; Macaca fascicularis; Male; Motor Activity; Prazosin; Receptors, Adrenergic, alpha | 2009 |
Peripheral COMT inhibition prevents levodopa associated homocysteine increase.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Delayed-Action Preparations; Dihydroxyphenylalanine; Enzyme Inhibitors; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Time Factors; Tyrosine | 2009 |
Stability of collagen in the presence of 3,4-dihydroxyphenylalanine (DOPA).
Topics: Circular Dichroism; Collagen; Cross-Linking Reagents; Dihydroxyphenylalanine; Levodopa; Spectrometry, Fluorescence; Transition Temperature | 2009 |
Dyskinesias do not develop after chronic intermittent levodopa therapy in clinically hemiparkinsonian rhesus monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Carotid Arteries; Conditioning, Operant; Corpus Striatum; Dihydroxyphenylalanine; Dopamine Agents; Dyskinesia, Drug-Induced; Dystonia; Female; Injections, Intravenous; Levodopa; Macaca mulatta; MPTP Poisoning; Parkinson Disease, Secondary; Psychomotor Performance; Radionuclide Imaging; Radiopharmaceuticals; Substantia Nigra | 2011 |
Sensitivity of kinetic macro parameters to changes in dopamine synthesis, storage, and metabolism: a simulation study for [¹⁸F]FDOPA PET by a model with detailed dopamine pathway.
Topics: Animals; Brain; Dihydroxyphenylalanine; Dopamine; Levodopa; Linear Models; Macaca fascicularis; Models, Neurological; Positron-Emission Tomography; Radiopharmaceuticals; Sensitivity and Specificity | 2011 |
Progression of monoaminergic dysfunction in Parkinson's disease: a longitudinal 18F-dopa PET study.
Topics: Amino Acid Transport Systems, Neutral; Antiparkinson Agents; Biogenic Monoamines; Decarboxylation; Dihydroxyphenylalanine; Dopamine; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Levodopa; Longitudinal Studies; Male; Middle Aged; Norepinephrine; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Serotonin | 2011 |
A longitudinal study of motor performance and striatal [18F]fluorodopa uptake in Parkinson's disease.
Topics: Aged; Aging; Antiparkinson Agents; Carbidopa; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; Female; Hand Strength; Humans; Isometric Contraction; Levodopa; Longitudinal Studies; Male; Middle Aged; Muscle Strength; Neuropsychological Tests; Parkinson Disease; Positron-Emission Tomography; Psychomotor Performance; Radiopharmaceuticals; Reaction Time; Retrospective Studies; Sex Characteristics; Tongue | 2011 |
Pyridoxal phosphate-responsive seizures in a patient with cerebral folate deficiency (CFD) and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM).
Topics: Base Sequence; Child; Codon, Nonsense; Congenital Abnormalities; Congenital Microtia; Dihydroxyphenylalanine; DNA Primers; Ear; Ear, Inner; Electroencephalography; Epilepsy; Fibroblast Growth Factor 3; Folate Receptor 1; Folic Acid Deficiency; Humans; Levodopa; Male; Molecular Sequence Data; Pyridoxal Phosphate; Radiography; Sequence Analysis, DNA; Skull; Syndrome; Tooth Abnormalities; Tyrosine | 2011 |
Partial trisomy 4q associated with young-onset dopa-responsive parkinsonism.
Topics: Adult; Age of Onset; alpha-Synuclein; Antiparkinson Agents; Chromosomes, Human, Pair 4; Dihydroxyphenylalanine; Dopamine Agonists; Female; Gene Duplication; Humans; Intellectual Disability; Karyotyping; Levodopa; Magnetic Resonance Imaging; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Trisomy | 2012 |
Seasonality of striatal dopamine synthesis capacity in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Female; Fluorine Radioisotopes; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Putamen; Seasons | 2012 |
A study on the electrochemical synthesis of L-DOPA using oxidoreductase enzymes: optimization of an electrochemical process.
Topics: Benzoquinones; Carbon; Dihydroxyphenylalanine; Electrochemical Techniques; Electrodes; Electron Transport; Electrons; Enzyme Activation; Enzyme Assays; Hydrogen-Ion Concentration; Levodopa; Monophenol Monooxygenase; Oxidation-Reduction; Platinum; Silver; Silver Compounds | 2012 |
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antiparkinson Agents; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluoresceins; Glial Fibrillary Acidic Protein; Hippocampus; Hydroxybenzoates; In Vitro Techniques; Kainic Acid; Levodopa; Male; Methylation; Mice; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors; Tyrosine | 2013 |
An increase in renal dopamine does not stimulate natriuresis after fava bean ingestion.
Topics: Adult; Blood Pressure; Catechols; Diet; Dihydroxyphenylalanine; Dopamine; Female; Humans; Kidney; Levodopa; Male; Middle Aged; Natriuresis; Renin; Sodium; Vicia faba; Young Adult | 2013 |
Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway.
Topics: Animals; Antiparkinson Agents; Aromatic-L-Amino-Acid Decarboxylases; Corpus Striatum; Dihydroxyphenylalanine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Levodopa; Macaca fascicularis; Magnetic Resonance Imaging; Male; Neural Pathways; Parkinsonian Disorders; Positron-Emission Tomography; Substantia Nigra | 2014 |
Assembly of surface-confined homochiral helicates: chiral discrimination of DOPA and unidirectional charge transfer.
Topics: Coordination Complexes; Dihydroxyphenylalanine; Levodopa; Metals; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Oxides; Polymers; Stereoisomerism | 2013 |
Enantiomeric determination of DOPA in dietary supplements containing Mucuna pruriens by liquid chromatography/mass spectrometry.
Topics: Chromatography, Liquid; Dietary Supplements; Dihydroxyphenylalanine; Formates; Levodopa; Mass Spectrometry; Mucuna; Plant Extracts; Solutions; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Water | 2013 |
A dual-tracer study of extrastriatal 6-[18F]fluoro-m-tyrosine and 6-[18F]-fluoro-L-dopa uptake in Parkinson's disease.
Topics: Brain; Dihydroxyphenylalanine; Disease Progression; Female; Fluorine Radioisotopes; Humans; Image Processing, Computer-Assisted; Levodopa; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Time Factors; Tyrosine | 2014 |
Simultaneous determination of levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma by an HPLC-MS/MS method.
Topics: Benzophenones; Blood Chemical Analysis; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Nitriles; Nitrophenols; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry; Tolcapone; Tyrosine | 2015 |
Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats.
Topics: Animals; Benzofurans; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Kinetics; Levodopa; Male; Metabolome; Methylation; Nitrophenols; Organ Specificity; Rats, Sprague-Dawley; Reproducibility of Results; Substrate Specificity; Tolcapone; Tyrosine | 2015 |
Evaluation of 6-11C-Methyl-m-Tyrosine as a PET Probe for Presynaptic Dopaminergic Activity: A Comparison PET Study with β-11C-l-DOPA and 18F-FDOPA in Parkinson Disease Monkeys.
Topics: Animals; Brain; Carbidopa; Dihydroxyphenylalanine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Enzyme Inhibitors; Levodopa; Macaca fascicularis; MPTP Poisoning; Parkinson Disease, Secondary; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Presynaptic; Tyrosine | 2016 |
Liquid-phase epitaxial growth of a homochiral MOF thin film on poly(L-DOPA) functionalized substrate for improved enantiomer separation.
Topics: Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Levodopa; Polymers; Stereoisomerism | 2016 |
Simultaneous estimation of levodopa, carbidopa and 3-oxymethyldopa in rat plasma using HPLC-ECD.
Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Electrochemical Techniques; Levodopa; Limit of Detection; Male; Rats; Rats, Wistar; Tyrosine | 2016 |
3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA.
Topics: Animals; Astrocytes; Catechol O-Methyltransferase Inhibitors; Catechols; Cells, Cultured; Corpus Striatum; Dihydroxyphenylalanine; Dopamine Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Glutathione; Levodopa; Mesencephalon; Neuroprotection; Neuroprotective Agents; Nitriles; Rats, Sprague-Dawley; Tyrosine | 2016 |
Levodopa, placebo and rotigotine change biomarker levels for oxidative stress.
Topics: Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dipeptides; Dopamine Agents; Electrochemical Techniques; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Tetrahydronaphthalenes; Thiophenes; Time Factors; Tyrosine | 2017 |
Stereoselective Nanozyme Based on Ceria Nanoparticles Engineered with Amino Acids.
Topics: Antiparkinson Agents; Catalysis; Cerium; Coenzymes; Dihydroxyphenylalanine; Humans; Kinetics; Levodopa; Metal Nanoparticles; Oxidation-Reduction; Particle Size; Phenylalanine; Stereoisomerism; Surface Properties | 2017 |
Properties of Electropolymerized Dopamine and Its Analogues.
Topics: 5-Hydroxytryptophan; Adsorption; Dihydroxyphenylalanine; Dopamine; Electrochemical Techniques; Epinephrine; Fibrinogen; Indoles; Levodopa; Molecular Structure; Polymerization; Polymers; Quartz Crystal Microbalance Techniques | 2019 |
Extended Treatment with Glial Cell Line-Derived Neurotrophic Factor in Parkinson's Disease.
Topics: Antiparkinson Agents; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Glial Cell Line-Derived Neurotrophic Factor; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Putamen; Randomized Controlled Trials as Topic | 2019 |
Exercise decreases aberrant corticostriatal plasticity in an animal model of l-DOPA-induced dyskinesia.
Topics: Animals; Antiparkinson Agents; Benserazide; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Dyskinesia, Drug-Induced; Exercise Therapy; Levodopa; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Mice, Inbred C57BL; Motor Activity; Neuronal Plasticity; Parkinsonian Disorders; Running; Time Factors | 2021 |
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota.
Topics: Animals; Berberine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Enterococcus faecalis; Enterococcus faecium; Gastrointestinal Microbiome; Humans; Levodopa; Mice; Parkinson Disease; Tyrosine 3-Monooxygenase | 2021 |
DOPA Homeostasis by Dopamine: A Control-Theoretic View.
Topics: Aging; Dihydroxyphenylalanine; Dopamine; Homeostasis; Humans; Levodopa; Models, Neurological; Oxidative Stress; Tyrosine 3-Monooxygenase | 2021 |