Page last updated: 2024-08-17

levodopa and d-alpha tocopherol

levodopa has been researched along with d-alpha tocopherol in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.03)18.7374
1990's19 (57.58)18.2507
2000's5 (15.15)29.6817
2010's7 (21.21)24.3611
2020's1 (3.03)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Nag, D1
Levivier, M; Przedborski, S1
Fahn, S1
Factor, SA; Sanchez-Ramos, JR; Weiner, WJ1
Abe, T; Hamato, F; Saheki, M; Sasaki, K; Takahashi, S; Tohgi, H1
Carter, J; Fahn, S; Gauthier, S; Goetz, CG; Golbe, LI; Jankovic, J; Koller, W; Lang, AE; McDermott, MP; Olanow, CW1
Calne, DB; Uitti, RJ; Vingerhoets, FJ1
Ahlskog, JE; Kokmen, E; Low, PA; Nickander, KK; Petersen, RC; Tyce, GM; Uitti, RJ1
Olanow, CW1
Heinonen, E; Mäki-Ikola, O1
Lai, CT; Yu, PH1
Cui, L; LeWitt, P; Oakes, D1
Chang, HC; Chen, RS; Liao, KK; Lu, CS; Tsai, CH1
Jiménez-Jiménez, FJ; Molina, JA1
Koller, WC1
Althaus, JS; Fici, GJ; VonVoigtlander, PF1
Carvey, PM; Ling, ZD; Robie, HC; Tong, CW1
Asanuma, M; Furuta, H; Miyazaki, I; Ogawa, N; Sogawa, CA; Sogawa, N1
Arlt, S; Beisiegel, U; Buhmann, C; Kontush, A; Möller-Bertram, T; Oechsner, M; Sperber, S; Stuerenburg, HJ1
Jankovic, J; Olanow, CW1
Hachinohe, M; Matsumoto, H1
Quach, HT; Smith, WE; Vatassery, GT1
Hauser, RA1
Bennett, JW; Inamdar, AA; Masurekar, P1
Chen, CH; Chen, NF; Chen, WF; Feng, CW; Hsiao, CD; Huang, SY; Hung, HC; Wang, HM; Wen, ZH; Yang, SN1
Jodko-Piórecka, K; Litwinienko, G1
Ahmadouk, NA; Gopaluni, S; Sherif, M1
Alam, T; Ali, J; Baboota, S; Gaba, B; Haider, MF; Khan, T; Parvez, S1
Bhuvanendran, S; Magalingam, KB; Radhakrishnan, AK; Ramdas, P; Selvaduray, KR; Somanath, SD1

Reviews

6 review(s) available for levodopa and d-alpha tocopherol

ArticleYear
[Current therapeutic approach in Parkinson disease].
    Revue medicale de Bruxelles, 1992, Volume: 13, Issue:10

    Topics: Antiparkinson Agents; Apomorphine; Bromocriptine; Fetal Tissue Transplantation; Humans; Levodopa; Mesencephalon; Parkinson Disease; Selegiline; Vitamin E

1992
[Neuroprotective and neurorestorative therapy in Parkinson's disease].
    Revista de neurologia, 1997, Volume: 25 Suppl 2

    Topics: Antiparkinson Agents; Apoptosis; Brain Tissue Transplantation; Chelation Therapy; Corpus Striatum; Dopamine; Erythrocytes; Free Radicals; Gangliosides; Genetic Therapy; Glutathione Peroxidase; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neurons; Oxidative Stress; Parkinson Disease; Selegiline; Selenium; Vitamin E

1997
Neuroprotection for Parkinson's disease.
    Annals of neurology, 1998, Volume: 44, Issue:3 Suppl 1

    Topics: Antiparkinson Agents; Clinical Trials as Topic; Dopamine Agents; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Selegiline; Vitamin E

1998
Neuroprotective therapy in Parkinson's disease and motor complications: a search for a pathogenesis-targeted, disease-modifying strategy.
    Movement disorders : official journal of the Movement Disorder Society, 2005, Volume: 20 Suppl 11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents; Coenzymes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Humans; Indans; Levodopa; Membrane Proteins; N-Methylaspartate; Neuroprotective Agents; Parkinson Disease; Prostaglandin-Endoperoxide Synthases; Ubiquinone; Vitamin E

2005
Early pharmacologic treatment in Parkinson's disease.
    The American journal of managed care, 2010, Volume: 16 Suppl Implications

    Topics: Antiparkinson Agents; Disease Progression; Dopamine Agonists; Early Diagnosis; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Ubiquinone; Vitamin E

2010
Interventions for chronic kidney disease-associated restless legs syndrome.
    The Cochrane database of systematic reviews, 2016, 11-07, Volume: 11

    Topics: Amines; Anticonvulsants; Ascorbic Acid; Cyclohexanecarboxylic Acids; Dopamine Agonists; Exercise Therapy; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Iron-Dextran Complex; Levodopa; Quality of Life; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Renal Replacement Therapy; Resistance Training; Restless Legs Syndrome; Vitamin E; Vitamins

2016

Trials

7 trial(s) available for levodopa and d-alpha tocopherol

ArticleYear
An open trial of high-dosage antioxidants in early Parkinson's disease.
    The American journal of clinical nutrition, 1991, Volume: 53, Issue:1 Suppl

    Topics: Adult; Aged; Ascorbic Acid; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Pilot Projects; Vitamin E

1991
Vitamin E therapy in Parkinson's disease.
    Advances in neurology, 1990, Volume: 53

    Topics: Aged; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Retrospective Studies; Vitamin E

1990
Effect of deprenyl on the progression of disability in early Parkinson's disease.
    The New England journal of medicine, 1989, 11-16, Volume: 321, Issue:20

    Topics: Activities of Daily Living; Clinical Trials as Topic; Drug Therapy, Combination; Employment; Female; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Multicenter Studies as Topic; Parkinson Disease; Phenethylamines; Random Allocation; Selegiline; Vitamin E

1989
Factors predictive of the need for levodopa therapy in early, untreated Parkinson's disease. The Parkinson Study Group.
    Archives of neurology, 1995, Volume: 52, Issue:6

    Topics: Adult; Age Factors; Aged; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Prospective Studies; Risk Factors; Selegiline; Sex Factors; Vitamin E

1995
Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP subjects not requiring levodopa. Parkinson Study Group.
    Annals of neurology, 1996, Volume: 39, Issue:1

    Topics: Aged; Antioxidants; Antiparkinson Agents; Disabled Persons; Disease Progression; Disease-Free Survival; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease, Secondary; Selegiline; Treatment Outcome; Vitamin E

1996
Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP patients requiring levodopa. Parkinson Study Group.
    Annals of neurology, 1996, Volume: 39, Issue:1

    Topics: Aged; Antioxidants; Antiparkinson Agents; Disabled Persons; Disease Progression; Disease-Free Survival; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease, Secondary; Selegiline; Treatment Outcome; Vitamin E

1996
The need for levodopa as an end point of Parkinson's disease progression in a clinical trial of selegiline and alpha-tocopherol. Parkinson Study Group.
    Movement disorders : official journal of the Movement Disorder Society, 1997, Volume: 12, Issue:2

    Topics: Activities of Daily Living; Adult; Aged; Antioxidants; Antiparkinson Agents; Disability Evaluation; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Selegiline; Treatment Outcome; Vitamin E

1997

Other Studies

20 other study(ies) available for levodopa and d-alpha tocopherol

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Therapy of Parkinson's disease: are we at the end of the road?
    The Journal of the Association of Physicians of India, 1992, Volume: 40, Issue:6

    Topics: Antiparkinson Agents; Dopamine Agents; Humans; India; Levodopa; Neurologic Examination; Parkinson Disease; Selegiline; Vitamin E

1992
Reduced and oxidized forms of glutathione and alpha-tocopherol in the cerebrospinal fluid of parkinsonian patients: comparison between before and after L-dopa treatment.
    Neuroscience letters, 1995, Jan-16, Volume: 184, Issue:1

    Topics: Aged; Glutathione; Glutathione Disulfide; Humans; Levodopa; Middle Aged; Parkinson Disease; Vitamin E

1995
Deprenyl and the issue of neuroprotection.
    European neurology, 1994, Volume: 34, Issue:1

    Topics: Antioxidants; Cell Survival; Clinical Trials as Topic; Disability Evaluation; Drug Administration Schedule; Humans; Levodopa; Neurons; Parkinson Disease; Selegiline; Substantia Nigra; Vitamin E

1994
No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease.
    Movement disorders : official journal of the Movement Disorder Society, 1995, Volume: 10, Issue:5

    Topics: Aged; Alzheimer Disease; Antiparkinson Agents; Brain; Cabergoline; Carbidopa; Diabetes Mellitus; Ergolines; Female; Free Radicals; Humans; Levodopa; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Parkinson Disease; Selegiline; Vitamin E

1995
A 61-year-old man with Parkinson's disease.
    JAMA, 1996, Mar-06, Volume: 275, Issue:9

    Topics: 1-Naphthylamine; Antiparkinson Agents; Carbidopa; Depression; Dopamine Agents; Drug Interactions; Drug Therapy, Combination; Family Practice; Humans; Levodopa; Male; Middle Aged; Neurology; Neuroprotective Agents; Parkinson Disease; Selegiline; Sertraline; Vitamin E

1996
Study design problems of DATATOP study analysis.
    Annals of neurology, 1996, Volume: 40, Issue:6

    Topics: Clinical Trials as Topic; Humans; Levodopa; Parkinson Disease; Placebos; Randomized Controlled Trials as Topic; Selegiline; Vitamin E

1996
Dopamine- and L-beta-3,4-dihydroxyphenylalanine hydrochloride (L-Dopa)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells. Effects of oxidative stress and antioxidative factors.
    Biochemical pharmacology, 1997, Feb-07, Volume: 53, Issue:3

    Topics: Ascorbic Acid; Catalase; Cell Survival; Deferoxamine; Dopamine; Levodopa; Lipid Peroxidation; Neuroblastoma; Oxidative Stress; Superoxide Dismutase; Tumor Cells, Cultured; Vitamin E

1997
Acanthocytosis and spinocerebellar degeneration: a new association?
    Movement disorders : official journal of the Movement Disorder Society, 1997, Volume: 12, Issue:3

    Topics: Acanthocytes; Adult; Anticonvulsants; Antiparkinson Agents; Carbidopa; Cerebellum; Clonazepam; Drug Therapy, Combination; Humans; Levodopa; Magnetic Resonance Imaging; Male; Spinocerebellar Degenerations; Videotape Recording; Vitamin E

1997
Pharmacological approaches to counter the toxicity of Dopa.
    Amino acids, 1998, Volume: 14, Issue:1-3

    Topics: Animals; Benzothiazoles; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Glutathione; Levodopa; Neuroprotective Agents; Pramipexole; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Selegiline; Thiazoles; Vitamin E

1998
Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    Topics: Animals; Antioxidants; Benzothiazoles; Cell Count; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Dopamine Agents; Dopamine Agonists; Levodopa; Mesencephalon; Neuroprotective Agents; Pramipexole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Thiazoles; Tyrosine 3-Monooxygenase; Vitamin E

1999
Antioxidants protect against dopamine-induced metallothionein-III (GIF) mRNA expression in mouse glial cell line (VR-2g).
    Brain research, 2000, Jan-24, Volume: 853, Issue:2

    Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Animals; Antioxidants; Ascorbic Acid; Cell Line; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Glutathione; Glycerol-3-Phosphate Dehydrogenase (NAD+); Glycerolphosphate Dehydrogenase; Levodopa; Metallothionein; Mice; Neuroglia; Norepinephrine; Oxidopamine; Protein Isoforms; Receptors, Dopamine D1; Receptors, Dopamine D2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vitamin E

2000
Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication.
    Neurobiology of disease, 2004, Volume: 15, Issue:1

    Topics: Adult; alpha-Tocopherol; Antioxidants; Antiparkinson Agents; Ascorbic Acid; Biomarkers; Brain; Dopamine; Female; Humans; Levodopa; Lipoproteins; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Reference Values; Sulfhydryl Compounds; Ubiquinone; Up-Regulation

2004
Involvement of reactive oxygen species generated from melanin synthesis pathway in phytotoxicty of L-DOPA.
    Journal of chemical ecology, 2005, Volume: 31, Issue:2

    Topics: alpha-Tocopherol; Antioxidants; Ascorbic Acid; Daucus carota; Dopamine; Lactuca; Levodopa; Lipid Peroxidation; Melanins; Oxidative Stress; Plant Roots; Poaceae; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Time Factors

2005
Effect of oxidative stress induced by L-dopa on endogenous antioxidants in PC-12 cells.
    Annals of the New York Academy of Sciences, 2006, Volume: 1074

    Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Dopamine Agents; Drug Interactions; Levodopa; Oxidative Stress; PC12 Cells; Rats

2006
Neurotoxicity of fungal volatile organic compounds in Drosophila melanogaster.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 117, Issue:2

    Topics: Air Pollution; Animals; Dopamine; Drosophila melanogaster; Environmental Monitoring; Fungi; Green Fluorescent Proteins; Housing; Levodopa; Locomotion; Male; Models, Animal; Nervous System; Neurons; Neurotoxins; Plant Extracts; Vitamin E; Volatile Organic Compounds

2010
Effects of 6-hydroxydopamine exposure on motor activity and biochemical expression in zebrafish (Danio rerio) larvae.
    Zebrafish, 2014, Volume: 11, Issue:3

    Topics: Animals; Antiparkinson Agents; Anxiety; Biomarkers; Blotting, Western; Carbidopa; Disease Models, Animal; Drug Combinations; Levodopa; Minocycline; Motor Activity; Oxidopamine; Parkinsonian Disorders; Real-Time Polymerase Chain Reaction; Sympatholytics; Vitamin E; Zebrafish; Zebrafish Proteins

2014
Antioxidant activity of dopamine and L-DOPA in lipid micelles and their cooperation with an analogue of α-tocopherol.
    Free radical biology & medicine, 2015, Volume: 83

    Topics: alpha-Tocopherol; Antioxidants; Catecholamines; Chromans; Dopamine; Dopamine Agents; Free Radical Scavengers; Humans; Kinetics; Levodopa; Linoleic Acids; Lipid Peroxidation; Liposomes; Micelles; Oxidation-Reduction; Oxidative Stress; Oxygen Consumption

2015
Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson's Disease Model.
    BioMed research international, 2019, Volume: 2019

    Topics: Administration, Intranasal; Animals; Antioxidants; Behavior, Animal; Emulsions; Female; Flavanones; Levodopa; Male; Nanoparticles; Oxidative Stress; Oxidopamine; Parkinson Disease; Particle Size; Rats; Rats, Wistar; Solubility; Viscosity; Vitamin E

2019
Tocotrienol-Rich Fraction and Levodopa Regulate Proteins Involved in Parkinson's Disease-Associated Pathways in Differentiated Neuroblastoma Cells: Insights from Quantitative Proteomic Analysis.
    Nutrients, 2022, Nov-03, Volume: 14, Issue:21

    Topics: Chromatography, Liquid; Humans; Levodopa; Neuroblastoma; Parkinson Disease; Proteomics; Tandem Mass Spectrometry; Tocotrienols; Vitamin E

2022