levocabastine has been researched along with piperidines in 184 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (10.33) | 18.7374 |
| 1990's | 92 (50.00) | 18.2507 |
| 2000's | 51 (27.72) | 29.6817 |
| 2010's | 20 (10.87) | 24.3611 |
| 2020's | 2 (1.09) | 2.80 |
| Authors | Studies |
|---|---|
| Vincent, JP | 1 |
| Bischoff, P; Gerber, M | 1 |
| Awouters, F; Jansen, T; Janssen, PA; Megens, AA; Niemegeers, CJ | 1 |
| Merkus, FW; Schüsler-van Hees, MT | 1 |
| Janssens, MM | 1 |
| Janssens, M | 1 |
| Blockhuys, S; Janssens, M; Parys, W | 1 |
| Jorde, W; Richarz-Barthauer, U; Schata, M | 1 |
| Bhatti, JZ; Curran, S; Hindmarch, I; Rombaut, N | 1 |
| Janssens, MM; Vanden Bussche, G | 1 |
| Blychert, LA; Kjellén, H; Rudblad, S; Wihl, JA | 1 |
| Chieira, C; Conde, TA; Cordeiro, JA; Palma-Carlos, AG | 1 |
| Almeida, J; Azevedo, M; Castel-Branco, MG; Delgado, L; Oliveira, JF; Ramos, E | 1 |
| Campbell, AD; Erwin, VG; Jones, BC | 1 |
| Dechant, KL; Goa, KL | 1 |
| Izushi, K; Kamei, C; Tasaka, K | 1 |
| Björkstén, B; Blychert, LO; Kjellman, NI; Rimås, M | 1 |
| Canonica, GW; Cerqueti, PM; Cilli, P; Ciprandi, G; Sacca, S | 1 |
| Arriaga, F; Rombaut, N | 1 |
| Aoki, I; Kamei, C; Tasaka, K; Tsujimoto, S; Yoshida, T | 1 |
| Bake, B; Blychert, LO; Holmberg, K; Pipkorn, U | 1 |
| af Klercker, T; Björkstén, B; Blychert, LO; Kjellman, NI; Odelram, H; Rimås, M | 1 |
| Dushay, ME; Johnson, CE | 1 |
| Leysen, JE; Schotte, A | 1 |
| Bende, M; Hedner, J; Hedner, T; Pipkorn, U | 1 |
| Kolly, M; Pécoud, A | 1 |
| Feinberg, G; Stokes, TC | 2 |
| Kolly, M; Pécoud, A; Zuber, P | 1 |
| Dussaillant, M; Kitabgi, P; Laduron, PM; Rostène, W; Schotte, A; Vincent, JP | 1 |
| Bende, M; Pipkorn, U | 1 |
| Palma-Carlos, AG; Palma-Carlos, ML; Rombaut, N | 1 |
| Pécoud, A; Zuber, P | 1 |
| Bateman, DN; Connolly, M; Ferner, RE; Kelly, C; Rawlins, MD; Ward, C | 1 |
| Harris, E; Pettibone, DJ; Robinson, FM; Totaro, JA | 1 |
| Laduron, PM; Leysen, JE; Schotte, A | 1 |
| Creten, W; Rombaut, N; van de Heyning, PH; van Haesendonck, J | 1 |
| Abelson, MB; Smith, LM | 1 |
| de Chaffoy de Courcelles, D; Leysen, JE; Niemegeers, CJ; Van Gompel, P | 1 |
| Akagi, M; Chokki, M; Kamei, C; Mio, M; Shirasaka, T; Tasaka, K | 1 |
| Kamei, C; Nakamura, S; Tasaka, K | 1 |
| Boegheim, JP; de Graaf-in 't Veld, T; Garrelds, IM; Gerth van Wijk, R; Mulder, PG; van Toorenenbergen, AW | 1 |
| Bahmer, FA | 1 |
| Blockhuys, S; Goes, F; Janssens, M | 1 |
| Schwab, IR | 1 |
| Abelson, MB; George, MA; Smith, LM | 1 |
| Mercer, M; Vermeulen, J | 1 |
| Biasi, D; Cortina, P; Lunardi, C; Maleknia, T; Pacor, ML | 1 |
| Davies, BH; Mullins, J | 1 |
| Erwin, VG; Radcliffe, RA | 1 |
| Blockhuys, S; Janssens, M | 1 |
| Górski, P; Pazdrak, K; Ruta, U | 1 |
| Heykants, J; Huang, ML; Stephen, A; Van Peer, A; Woestenborghs, R; Zazgornik, J | 1 |
| Bahmer, FA; Ruprecht, KW | 1 |
| Abelson, MB; George, MA; Schaefer, K; Smith, LM | 1 |
| Trayner, EM | 1 |
| Campbell, AD; Erwin, VG | 1 |
| Dahl, R; Larsen, BB; Pedersen, B | 1 |
| Frostad, AB; Olsen, AK | 1 |
| Freng, BA; Garud, O; Korsrud, FR; Kramer, J; Olsen, AK; Poppe, S; Rebo, R; Søhoel, P; Woxen, OJ | 1 |
| Heykants, J; Meuldermans, W; Snoeck, E; Van de Velde, V; Van Peer, A; Woestenborghs, R | 1 |
| Dahl, R; Larsen, B; Pedersen, B | 1 |
| Boegheim, JP; de Graaf-in't Veld, T; Garrelds, IM; Saxena, PR; van Toorenenbergen, AW; van Wijk, RG; Zijlstra, FJ | 1 |
| McTavish, D; Noble, S | 1 |
| Joseph Titi, M | 1 |
| Bonnin, J; Caput, D; Chalon, P; Delpech, B; Ferrara, P; Guillemot, M; Kaghad, M; Le Fur, G; Vita, N | 1 |
| Botto, JM; Coppola, T; Guillemare, E; Mazella, J; Sarret, P; Vincent, JP | 1 |
| Bagnasco, M; Buscaglia, S; Canonica, GW; Catrullo, A; Ciprandi, G; Fiorino, N; Montagna, P; Paolieri, F; Pesce, G; Riccio, AM | 1 |
| Biasi, D; Carletto, A; Lunardi, C; Maleknia, T; Pacor, ML | 1 |
| Bachert, C; Vossen-Holzenkamp, S; Wagenmann, M | 1 |
| Gerber, M; Hammann, C; Kämmerer, R; Spertini, F | 1 |
| Magnino, PE; Pang, IH; Sharif, NA; Xu, SX | 1 |
| Botto, JM; Mazella, J; Sarret, P; Vincent, JP | 1 |
| Alonso, R; Beaudet, A; Faure, MP; Nouel, D; Quirion, R; St Pierre, JA | 1 |
| Botto, JM; Guillemare, E; Mazella, J; Vincent, JP | 1 |
| Ito, N; Kanai, A; Momose, T; Shibata, M; Watanabe, Y | 1 |
| Couturier, C; Goldschmidt, P; Haeffner-Cavaillon, N; Herman, D; Kazatchkine, M | 1 |
| Krásný, J; Plísková, S; Síblová, O; Stara, J | 1 |
| Blessmann, G; Wertheimer, R | 1 |
| Bassiouny, M; Elwany, S | 1 |
| Botto, JM; Chabry, J; Mazella, J; Sarret, P; Vincent, JP | 1 |
| Cusack, B; Groshan, K; Richelson, E; Tyler, BM | 1 |
| Betancur, C; Burgos, A; Canton, M; Gully, D; Labeeuw, B; Pélaprat, D; Rostène, W | 1 |
| Hofmann, T; Koidl, B; Wolf, G | 1 |
| Andersson, M; Blychert, LO; Greiff, L; Persson, CG; Svensson, C | 1 |
| Forgez, P; Lombet, A; Rostène, W; Yamada, M | 1 |
| Betancur, C; Caput, D; Ferrara, P; Fournier, J; Lepee-Lorgeoux, I; Rostene, W; Walker, N | 1 |
| Azzolin, NM; Baraldi, E; Carrà, S; Dario, C; Marchesini, L; Zacchello, F | 1 |
| Marzetto, M; Sabbah, A | 1 |
| Andersson, M; Greiff, L; Hjertson, M; Nilsson, G; Nilsson, K; Siegbahn, A; Svensson, C | 1 |
| Goldschmidt, O; Kremer, B; Tündermann, A | 1 |
| Bukowczan, Z; Doniec, Z; Kossek, M; Kurzawa, R; Mazurek, H; Radliński, J; Sak-Kopytyńska, I; Urbanek, E | 1 |
| Boigegrain, R; Durant, F; Gully, D; Labeeuw, B; Longfils, G; Quéré, L | 1 |
| Bisgaard, H; Borum, S; Mygind, N; Nielsen, K | 1 |
| Grover, M; Hall, N; Hassell, A; Hunt, T; Lee, P; Mechlinski, W; Pesco-Koplowitz, L; Smith, R; Travers, S; Wiesinger, B; Zhou, H | 1 |
| Verin, P | 1 |
| Betancur, C; Lépée-Lorgeoux, I; Pélaprat, D; Rostène, W | 1 |
| Corren, J; Holton, D; Karcher, K; Rachelefsky, G; Schanker, H; Siegel, S; Spector, S; Travers, S | 1 |
| Bédard, PJ; Di Paolo, T; Falardeau, P; Goulet, M; Grondin, R; Morissette, M; Rostène, W | 1 |
| Laissue, JA; Reubi, JC; Schaer, JC; Waser, B | 1 |
| Grzelewska-Rzymowska, I; Pietrzkowicz, M | 1 |
| Candore, G; Caruso, C; Colombo, A; Cosentino, D; Di Lorenzo, G; Di Salvo, A; Drago, A; Esposito Pellitteri, M; Gervasi, F; Mansueto, S; Potestio, M | 1 |
| Costentin, J; Dubuc, I; Remande, S | 1 |
| Matthews, RT | 1 |
| Bagnato, G; Bonifazi, F; Crimi, N; Di Lorenzo, G; Emmi, L; Fina, P; Foresi, A; Leone, C; Mirone, C; Ortolani, C; Prandini, M; Senna, GE; Testi, R; Tursi, A | 1 |
| Iba, Y; Ishizawa, K; Kamei, C; Sugimoto, Y; Suzuki, G | 1 |
| Trudeau, LE | 1 |
| López Ordieres, MG; Rodríguez de Lores Arnaiz, G | 1 |
| Abelson, MB; Ciprandi, G; Deschenes, J; Leonardi, A; Secchi, A | 1 |
| Abelson, MB; Deschenes, J; Discepola, M; Leonardi, A; Secchi, A | 1 |
| Krenzer, KL; Leahy, C; Netland, PA | 1 |
| Ellers-Lenz, B; Giede, C; Metzenauer, P; Petzold, U | 1 |
| Berdeaux, G; Fagnani, F; Lafuma, A; Nuijten, MJ; Pinto, CG | 1 |
| Asselin, ML; Coquerel, A; Costentin, J; Dubuc, I | 1 |
| Botto, JM; Dal Farra, C; Mazella, J; Navarro, V; Sarret, P; Vincent, JP | 1 |
| Azriel, Y; Burcher, E | 1 |
| Abrantes, P; Apel, AJ; Brancato, R; Carmichael, TR; Cerqueti, PM; Ciprandi, G; Coroneo, MT; Coster, DJ; Easty, DL; Estivin-Ebrardt, C; Harrisberg, CJ; Kent-Smith, BT; Knorr, M; Leonardi, A; Martinez, M; Modorati, G; Nemeth-Wasmer, G; Partouche, P; Secchi, A; Verin, P | 1 |
| Baehre, M; Falser, N; Rahlfs, VW; Wober, W | 1 |
| Ahluwalia, P; Anderson, DF; Church, MK; McGill, JI; Wilson, SJ | 1 |
| Barroso, S; Kitabgi, P; Labbé-Jullié, C; Martinez, J; Richard, F | 1 |
| Akiyoshi, M; Enomoto, S; Hirano, F; Maki, E; Shigeoka, T; Takahashi, H; Torii, S | 1 |
| Greengard, P; Higashi, H; Maeda, H; Matsuyama, S; Nishi, A | 1 |
| Garcia-Marin, L; Jensen, RT; Leyton, J; Moody, TW | 1 |
| Beaudet, A; Gallo-Payet, N; Gendron, L; Kilian, P; Nguyen, HM; Payet, MD; Sarret, P | 1 |
| Rodrigo, GJ; Yáñez, A | 1 |
| Nenciu, A; Stefan, C | 1 |
| Rao, K; Wang, S; Wang, Z; Xu, R; Xu, Z | 1 |
| Canonica, GW; Ciprandi, G; Ellers-Lenz, B; Hermann, R; Kolb, C; Petzold, U | 1 |
| Blondin, C; Cholley, B; Goldschmidt, P; Haeffner-Cavaillon, N | 1 |
| Fukui, R; Higashi, H; Matsuyama, S; Nishi, A | 1 |
| BEJSOVEC, M | 1 |
| Cooper, C; Kidd, M; Lanz, R; McKenzie, SH; Steven, I | 1 |
| Colin, J; Depont, F; Jacquet, A; Moore, N; Mortemousque, B; Richard, C | 1 |
| Abelson, MB; Bradford, R; Lue, J; Schiffman, RM; Whitcup, SM | 1 |
| Ohinata, K; Yamauchi, R; Yoshikawa, M | 1 |
| Beaudet, A; Gallo-Payet, N; Gendron, L; Payet, MD; Perron, A; Sarret, P | 1 |
| Beaudet, A; Gendron, L; Perron, A; Sarret, P; Stroh, T | 1 |
| Abelson, MB; Greiner, JV | 1 |
| Hossen, MA; Kamei, C; Minami, K | 1 |
| Schoch, C | 1 |
| Braccioni, F; Contoli, M; Frati, F; Giovannini, M; Incorvaia, C; Perri, G; Sella, G | 1 |
| Allaire, C; Bibas, P; Lablache-Combier, M; Richard, C | 1 |
| Beaudet, A; Esdaile, MJ; Martinez, J; Perron, A; Sarret, P; Stroh, T | 1 |
| Bachert, C; Holtappels, G; Lange, B; Lukat, KF; Rettig, K | 1 |
| Bredeloux, P; Costentin, J; Dubuc, I | 1 |
| Fujishima, H; Fukada, Y; Fukagawa, K; Nomura, K; Satake, Y; Sawa, M; Takamura, E; Uchida, E | 1 |
| Fujishima, H; Fukagawa, K; Fukushima, A; Nakagawa, Y; Okamoto, S; Takamura, E; Takano, Y; Uchio, E; Yokoi, N | 1 |
| Cheng, L; Dake, Y; Enomoto, K; Enomoto, T; Ikeda, H; Sakota, T; Shibano, A; Yajin, S; Yamanishi, E; Yoda, S | 1 |
| Bortolotti, M; Bremond-Gignac, D; Delval, L; Fregona, IA; Grouin, JM; Leonardi, A; Pouliquen, P; Violato, D | 1 |
| Anzic, SA; Dzepina, D; Kalogjera, L | 1 |
| Fujishima, H; Fukagawa, K; Fukushima, A; Miyazaki, D; Nakagawa, Y; Okamoto, S; Takamura, E; Tanaka, M; Uchio, E; Yokoi, N | 1 |
| Baiula, M; Bedini, A; Bucolo, C; Fascì, D; Govoni, P; Qasem, AR; Spampinato, S; Spartà, A | 1 |
| Colin, J; Hartani, D; Lazreg, S; Renault, D | 1 |
| Asaoka, R; Hotta, Y; Liu, Y; Nakagamil, T; Zhu, H | 1 |
| Baudisson, S; Beaudet, N; Belleville, K; Dansereau, MA; Ezzoubaa, F; Martinez, J; Richelson, E; Roussy, G; Sarret, P | 1 |
| Barbut, D; Boules, M; Liang, Y; Richelson, E; Shaw, A | 1 |
| Hou, IC; Ohinata, K; Yoshikawa, M | 1 |
| Hong, S; Lü, P | 1 |
| Abderrahmani, A; Béraud-Dufour, S; Brau, F; Coppola, T; Mazella, J; Noel, J; Waeber, G | 1 |
| Hirakawa, N; Yano, H; Yanoshita, R; Yoshii, M | 1 |
| Chen, L; Cheng, L; Fu, Z; Han, D; Liu, S; Wang, C; Xi, L; Zhang, L; Zhang, W | 1 |
| Hou, IC; Kanegawa, N; Oda, A; Ohinata, K; Sekiguchi, M; Suzuki, C; Wada, E; Wada, K; Yamada, A; Yamada, D; Yoshikawa, M | 1 |
| Arnaiz, GR; Ordieres, MG; Rosin, C | 1 |
| Hugel, S; Kadiri, N; Rodeau, JL; Schlichter, R | 1 |
| Bogdański, P; Krauss, H; Maćkowiak, P; Nowak, D; Piątek, J | 1 |
| Allaire, C; Bassols, A; Siou-Mermet, R | 1 |
| Boules, M; Richelson, E; Smith, KE; Williams, K | 1 |
| Beaudet, N; Behlke, MA; Belleville, K; Cavelier, F; Jacobi, AM; Martinez, J; Perron, A; René, A; Rose, SD; Sarret, P; Stroh, T; Tétreault, P | 1 |
| Hara, Y; Kawasaki, S; Ohashi, Y; Shiraishi, A; Uno, T; Yamaguchi, M | 1 |
| Calvo, P; Guzman-Aranguez, A; Pintor, J; Ropero, I | 1 |
| Bareille, P; Boardley, R; Gupta, A; Horak, F; Ignar, D; Lemel, P; Miller, SR; Murdoch, RD; Zieglmayer, P; Zieglmayer, R | 1 |
| Bareille, P; Gupta, A; Ignar, D; Mark, S; Miller, SR; Murdoch, RD; Patel, P; Salapatek, AM | 1 |
| Gutnisky, A; López Ordieres, MG; Rodríguez de Lores Arnaiz, G | 1 |
| Allen, A; Bareille, P; Burns, O; Gupta, A; Hughes, S; Miller, SR; Murdoch, RD | 1 |
| Choi, D; Guo, J; McCullough, KM; Rainnie, DG; Ressler, KJ; Walton, J; Zimmerman, K | 1 |
| Gutnisky, A; Karadayian, AG; Lores-Arnaiz, S; Rodríguez de Lores Arnaiz, G | 1 |
| Ahn, J; Kang, SK; Lee, J; Nam, DH; Sim, J; Suh, YG | 1 |
| Ben-Eli, H; Solomon, A | 1 |
| Abdelhameed, AS; Ajmal, MR; Al-Alawy, AIA; Almutairi, FM; Khan, RH; Majid, N; Siddiqi, MK | 1 |
| Gutnisky, A; Karadayian, AG; Lores-Arnaiz, S; Miranda, J; Rodríguez de Lores Arnaiz, G | 1 |
17 review(s) available for levocabastine and piperidines
| Article | Year |
|---|---|
Neurotensin receptors. Binding properties, transduction mechanisms, and purification.
Topics: Amino Acid Sequence; Animals; Brain; Cholic Acids; Chromatography; Mice; Molecular Sequence Data; Piperidines; Receptors, Neurotensin; Receptors, Neurotransmitter; Transduction, Genetic | 1992 |
Levocabastine: a new topical approach for the treatment of paediatric allergic rhinoconjunctivitis.
Topics: Administration, Intranasal; Animals; Child; Clinical Trials as Topic; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Nasal Provocation Tests; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1992 |
Efficacy of levocabastine in conjunctival provocation studies.
Topics: Conjunctivitis, Allergic; Evaluation Studies as Topic; Histamine H1 Antagonists; Humans; Ophthalmic Solutions; Piperidines; Premedication | 1992 |
New trends in the treatment of allergic conjunctivitis.
Topics: Animals; Antazoline; Conjunctivitis, Allergic; Cromolyn Sodium; Histamine H1 Antagonists; Humans; Naphazoline; Ophthalmic Solutions; Piperidines; Placebos; Terfenadine | 1992 |
Levocabastine: an effective topical treatment of allergic rhinoconjunctivitis.
Topics: Administration, Topical; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1991 |
Levocabastine. A review of its pharmacological properties and therapeutic potential as a topical antihistamine in allergic rhinitis and conjunctivitis.
Topics: Administration, Topical; Animals; Conjunctivitis, Allergic; Cromolyn Sodium; Drug Evaluation; Drug Tolerance; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Perennial | 1991 |
Management of allergic rhinitis: focus on intranasal agents.
Topics: Administration, Intranasal; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Budesonide; Glucocorticoids; Histamine H1 Antagonists; Humans; Ipratropium; Nedocromil; Piperidines; Pregnenediones; Quinolones; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1989 |
Topical levocabastine--an effective alternative to oral antihistamines in seasonal allergic rhinoconjunctivitis.
Topics: Administration, Oral; Administration, Topical; Clinical Trials as Topic; Conjunctivitis, Allergic; Double-Blind Method; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Terfenadine | 1995 |
The pharmacokinetic properties of topical levocabastine. A review.
Topics: Administration, Topical; Animals; Histamine H1 Antagonists; Humans; Piperidines; Skin Absorption | 1995 |
Levocabastine. An update of its pharmacology, clinical efficacy and tolerability in the topical treatment of allergic rhinitis and conjunctivitis.
Topics: Aerosols; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal | 1995 |
A critical look at ocular allergy drugs.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Ketorolac Tromethamine; Oxamic Acid; Piperidines; Tolmetin; Tromethamine | 1996 |
Treating severe eye allergy.
Topics: Anti-Allergic Agents; Conjunctivitis, Allergic; Controlled Clinical Trials as Topic; Cromolyn Sodium; Histamine H1 Antagonists; Humans; Nedocromil; Patient Satisfaction; Piperidines | 1998 |
[Second generation topical antihistaminics].
Topics: Administration, Topical; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Allergic; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; Nasal Mucosa; Phthalazines; Piperidines; Rhinitis, Allergic, Perennial | 1999 |
[Pharmacological and clinical properties of levocabastine hydrochloride (eye drop and nasal spray), a selective H1 antagonist].
Topics: Animals; Chemotaxis, Leukocyte; Clinical Trials as Topic; Conjunctivitis, Allergic; Depression, Chemical; Disease Models, Animal; Eosinophils; Histamine H1 Antagonists; Histamine Release; Humans; Mast Cells; Neutrophils; Piperidines; Rhinitis, Allergic, Perennial | 2002 |
Intranasal corticosteroids versus topical H1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis.
Topics: Administration, Intranasal; Administration, Topical; Adolescent; Adult; Aged; Androstadienes; Anti-Allergic Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beclomethasone; Budesonide; Fluocinolone Acetonide; Fluticasone; Glucocorticoids; Histamine H1 Antagonists; Humans; Middle Aged; Phthalazines; Piperidines; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2002 |
[Ocular injuries due to allergic mechanism].
Topics: Anti-Inflammatory Agents; Conjunctivitis, Allergic; Cyclosporine; Drug Therapy, Combination; Histamine H1 Antagonists; Humans; Immunoglobulin E; Immunosuppressive Agents; Ophthalmic Solutions; Piperidines; Prednisone | 2002 |
Topical antihistamines, mast cell stabilizers, and dual-action agents in ocular allergy: current trends.
Topics: Administration, Ophthalmic; Anti-Allergic Agents; Benzazepines; Conjunctivitis, Allergic; Cromolyn Sodium; Dibenzazepines; Histamine Antagonists; Humans; Hyperemia; Imidazoles; Ketotifen; Nedocromil; Olopatadine Hydrochloride; Phthalazines; Piperidines; Pruritus; Pyridines; Pyrimidinones | 2018 |
81 trial(s) available for levocabastine and piperidines
| Article | Year |
|---|---|
[Multicenter evaluation of a new local antihistaminic drug (levocabastine)].
Topics: Adult; Conjunctivitis, Allergic; Female; Histamine H1 Antagonists; Humans; Male; Ophthalmic Solutions; Piperidines | 1992 |
New trends in the treatment of allergic conjunctivitis.
Topics: Animals; Antazoline; Conjunctivitis, Allergic; Cromolyn Sodium; Histamine H1 Antagonists; Humans; Naphazoline; Ophthalmic Solutions; Piperidines; Placebos; Terfenadine | 1992 |
Levocabastine nasal spray better than sodium cromoglycate and placebo in the topical treatment of seasonal allergic rhinitis.
Topics: Administration, Intranasal; Administration, Topical; Adolescent; Adult; Cromolyn Sodium; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Placebos; Rhinitis, Allergic, Seasonal | 1991 |
Effects of topical administration of levocabastine on psychomotor and cognitive function.
Topics: Administration, Topical; Adolescent; Adult; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Middle Aged; Piperidines; Psychomotor Performance | 1991 |
Levocabastine eye drops versus sodium cromoglycate in seasonal allergic conjunctivitis.
Topics: Adolescent; Adult; Cohort Studies; Conjunctivitis, Allergic; Cromolyn Sodium; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines | 1991 |
Double-blind comparison of levocabastine nasal spray with sodium cromoglycate nasal spray in the treatment of seasonal allergic rhinitis.
Topics: Administration, Intranasal; Adolescent; Adult; Child; Cromolyn Sodium; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Severity of Illness Index | 1991 |
Double-blind comparison of levocabastine eye drops with sodium cromoglycate and placebo in the treatment of seasonal allergic conjunctivitis.
Topics: Adolescent; Adult; Child; Conjunctivitis, Allergic; Cromolyn Sodium; Double-Blind Method; Histamine H1 Antagonists; Humans; Middle Aged; Ophthalmic Solutions; Piperidines | 1991 |
Topical levocabastine protects better than sodium cromoglycate and placebo in conjunctival provocation tests.
Topics: Adolescent; Child; Conjunctivitis, Allergic; Cromolyn Sodium; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Ophthalmic Solutions; Piperidines; Pollen; Random Allocation | 1990 |
Levocabastine versus cromolyn sodium in the treatment of pollen-induced conjunctivitis.
Topics: Administration, Topical; Adolescent; Adult; Clinical Trials as Topic; Conjunctivitis, Allergic; Cromolyn Sodium; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Pollen | 1990 |
Absence of central effects with levocabastine eye drops.
Topics: Adult; Central Nervous System; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Psychomotor Performance | 1990 |
Effects of topical treatment with H1 and H2 antagonists on clinical symptoms and nasal vascular reactions in patients with allergic rhinitis.
Topics: Administration, Topical; Adult; Airway Resistance; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Nasal Provocation Tests; Nose; Piperidines; Random Allocation; Ranitidine; Rhinitis, Allergic, Seasonal | 1989 |
Topical levocabastine versus sodium cromoglycate in allergic conjunctivitis.
Topics: Adolescent; Child; Conjunctivitis, Allergic; Cromolyn Sodium; Double-Blind Method; Histamine H1 Antagonists; Humans; Ophthalmic Solutions; Piperidines; Pollen; Randomized Controlled Trials as Topic | 1989 |
A double-blind evaluation of topical levocabastine, a new specific H1 antagonist in patients with allergic conjunctivitis.
Topics: Adolescent; Adult; Clinical Trials as Topic; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines | 1985 |
Comparison of levocabastine, a new selective H1-receptor antagonist, and disodium cromoglycate, in a nasal provocation test with allergen.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Child; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Nasal Mucosa; Nasal Provocation Tests; Piperidines; Sneezing | 1986 |
Effect of a new selective H1 receptor antagonist (levocabastine) in a nasal and conjunctival provocation test.
Topics: Administration, Topical; Adolescent; Adult; Child; Conjunctivitis, Allergic; Drug Evaluation; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nasal Provocation Tests; Piperidines; Rhinitis, Allergic, Seasonal | 1987 |
Topical levocabastine, a selective H1 antagonist, in seasonal allergic rhinoconjunctivitis.
Topics: Administration, Intranasal; Adolescent; Adult; Conjunctivitis, Allergic; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Random Allocation; Rhinitis, Allergic, Seasonal | 1987 |
The effect of levocabastine nasal spray in nasal provocation tests.
Topics: Administration, Intranasal; Adolescent; Adult; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nasal Provocation Tests; Piperidines; Rhinitis | 1988 |
Effect of levocabastine, a new H1 antagonist, in a conjunctival provocation test with allergens.
Topics: Allergens; Conjunctiva; Conjunctivitis, Allergic; Dose-Response Relationship, Immunologic; Female; Histamine H1 Antagonists; Humans; Male; Piperidines | 1988 |
Reversal of histamine-induced bronchoconstriction by the H1-receptor antagonist levocabastine: a potential model for efficacy in anaphylaxis.
Topics: Adult; Anaphylaxis; Bronchial Spasm; Double-Blind Method; Forced Expiratory Volume; Histamine; Histamine H1 Antagonists; Humans; Kinetics; Male; Middle Aged; Piperidines; Random Allocation | 1988 |
Effect of topical levocabastine on allergic and non-allergic perennial rhinitis. A double-blind study, levocabastine vs. placebo, followed by an open, prospective, single-blind study on beclomethasone.
Topics: Administration, Intranasal; Beclomethasone; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1988 |
Effect of topical levocabastine on nasal response to allergen challenge and nasal hyperreactivity in perennial rhinitis.
Topics: Administration, Topical; Adult; Albumins; Allergens; Animals; Antigens, Dermatophagoides; Chymases; Cross-Over Studies; Double-Blind Method; Female; Glycoproteins; Histamine; Histamine H1 Antagonists; Humans; Male; Methacholine Chloride; Middle Aged; Mites; Nasal Lavage Fluid; Nasal Mucosa; Nasal Provocation Tests; Piperidines; Rhinitis, Allergic, Perennial; Serine Endopeptidases; Tryptases | 1995 |
Topical levocabastine compared with oral loratadine for the treatment of seasonal allergic rhinoconjunctivitis. Swedish GP Allergy Team.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aerosols; Aged; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal | 1994 |
Levocabastine eye drops in the treatment of vernal conjunctivitis.
Topics: Adolescent; Adult; Child; Child, Preschool; Conjunctivitis, Allergic; Double-Blind Method; Drug Tolerance; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Prognosis | 1994 |
Evaluation of 0.05% levocabastine versus 4% sodium cromolyn in the allergen challenge model.
Topics: Allergens; Conjunctivitis, Allergic; Cromolyn Sodium; Histamine H1 Antagonists; Humans; Models, Biological; Ophthalmic Solutions; Piperidines | 1995 |
Comparison of the efficacy and tolerability of topical levocabastine and sodium cromoglycate in the treatment of seasonal allergic rhinoconjunctivitis in children.
Topics: Administration, Intranasal; Adolescent; Child; Conjunctivitis, Allergic; Cromolyn Sodium; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal | 1994 |
[Usefulness of levocabastine for topical use in seasonal allergic rhinitis].
Topics: Administration, Topical; Adult; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Seasonal | 1994 |
Topical levocabastine is more effective than sodium cromoglycate for the prophylaxis and treatment of seasonal allergic conjunctivitis.
Topics: Administration, Topical; Adolescent; Adult; Aged; Child; Conjunctivitis, Allergic; Cromolyn Sodium; Double-Blind Method; Histamine H1 Antagonists; Humans; Middle Aged; Piperidines | 1993 |
A comparison of topical levocabastine and oral terfenadine in the treatment of allergic rhinoconjunctivitis. The Livostin Study Group.
Topics: Administration, Intranasal; Administration, Oral; Adult; Conjunctivitis, Allergic; Double-Blind Method; Histamine H1 Antagonists; Humans; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine | 1993 |
Tolerability of levocabastine eye drops.
Topics: Adolescent; Adult; Conjunctivitis, Allergic; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Female; Histamine H1 Antagonists; Humans; Male; Ophthalmic Solutions; Piperidines; Terfenadine; Visual Acuity | 1993 |
Inhibitory effect of levocabastine on allergen-induced increase of nasal reactivity to histamine and cell influx.
Topics: Adult; Albumins; Allergens; Animals; Cell Count; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Mites; Nasal Lavage Fluid; Nasal Provocation Tests; Piperidines; Rhinitis, Allergic, Perennial | 1993 |
Safety and efficacy of topical levocabastine compared with oral terfenadine.
Topics: Administration, Oral; Administration, Topical; Adult; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine | 1994 |
Evaluation of the new ophthalmic antihistamine, 0.05% levocabastine, in the clinical allergen challenge model of allergic conjunctivitis.
Topics: Adolescent; Adult; Allergens; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Models, Biological; Ophthalmic Solutions; Piperidines | 1994 |
A comparison of topical levocabastine and sodium cromoglycate in the treatment of pollen-provoked allergic conjunctivitis.
Topics: Administration, Topical; Adult; Allergens; Conjunctivitis, Allergic; Cromolyn Sodium; Double-Blind Method; Histamine H1 Antagonists; Humans; Longitudinal Studies; Middle Aged; Ophthalmic Solutions; Piperidines; Pollen | 1993 |
Topical levocabastine compared with orally administered terfenadine for the prophylaxis and treatment of seasonal rhinoconjunctivitis.
Topics: Administration, Oral; Adult; Aerosols; Conjunctivitis, Allergic; Double-Blind Method; Drug Tolerance; Female; Histamine H1 Antagonists; Humans; Male; Norway; Ophthalmic Solutions; Piperidines; Remission Induction; Rhinitis, Allergic, Seasonal; Terfenadine | 1993 |
Intranasal levocabastine for the treatment of seasonal allergic rhinitis: a multicentre, double-blind, placebo-controlled trial.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal | 1995 |
Topical ocular levocabastine reduces ICAM-1 expression on epithelial cells both in vivo and in vitro.
Topics: Acute-Phase Reaction; Administration, Topical; Adolescent; Adult; Cells, Cultured; Cross-Over Studies; Double-Blind Method; Drug Administration Routes; Epithelium; Eye; Female; Humans; Hypersensitivity, Delayed; Intercellular Adhesion Molecule-1; Male; Middle Aged; Piperidines | 1996 |
[Efficacy of levocabastine in perennial rhinitis].
Topics: Administration, Intranasal; Adult; Aerosols; Analysis of Variance; Conjunctivitis; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Perennial | 1996 |
Intranasal levocabastine provides fast and effective protection from nasal allergen challenge.
Topics: Administration, Intranasal; Adult; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Nasal Provocation Tests; Piperidines; Rhinitis, Allergic, Seasonal; Severity of Illness Index | 1996 |
Comparison of effects of topical levocabastine and nedocromil sodium on the early response in a conjunctival provocation test with allergen.
Topics: Administration, Topical; Adolescent; Adult; Allergens; Conjunctiva; Conjunctivitis, Allergic; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Immune Tolerance; Male; Middle Aged; Nedocromil; Piperidines; Pollen | 1996 |
[An open and controlled study of effectiveness and tolerance of Livostin eyedrops].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Conjunctivitis, Allergic; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines | 1997 |
[Antazoline/tetryzoline eyedrops in comparison with levocabastine eyedrops in acute allergic conjunctivitis].
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Antazoline; Anti-Allergic Agents; Conjunctivitis, Allergic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Histamine H1 Antagonists; Humans; Imidazoles; Male; Middle Aged; Nasal Decongestants; Ophthalmic Solutions; Piperidines | 1997 |
Topical levocabastine for the treatment of perennial allergic rhinitis.
Topics: Administration, Intranasal; Adult; Chronic Disease; Female; Histamine H1 Antagonists; Humans; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Nasal Mucosa; Piperidines; Rhinitis, Allergic, Perennial; Treatment Outcome | 1997 |
Effects of topical budesonide and levocabastine on nasal symptoms and plasma exudation responses in seasonal allergic rhinitis.
Topics: Administration, Intranasal; Adult; Anti-Inflammatory Agents; Budesonide; Capillary Permeability; Female; Glucocorticoids; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Single-Blind Method | 1998 |
Effect of topical steroids on nasal nitric oxide production in children with perennial allergic rhinitis: a pilot study.
Topics: Adolescent; Anti-Inflammatory Agents; Beclomethasone; Child; Child, Preschool; Female; Histamine H1 Antagonists; Humans; Male; Nitric Oxide; Pilot Projects; Piperidines; Rhinitis, Allergic, Perennial; Treatment Outcome | 1998 |
Azelastine eye drops in the treatment of seasonal allergic conjunctivitis or rhinoconjunctivitis in young children.
Topics: Child; Child, Preschool; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Ophthalmic Solutions; Phthalazines; Piperidines; Rhinitis, Allergic, Seasonal; Severity of Illness Index | 1998 |
Demonstration of mast-cell chemotactic activity in nasal lavage fluid: characterization of one chemotaxin as c-kit ligand, stem cell factor.
Topics: Allergens; Budesonide; Cell Line; Chemotactic Factors; Chemotaxis, Leukocyte; Enzyme-Linked Immunosorbent Assay; Humans; Mast Cells; Nasal Lavage Fluid; Nasal Provocation Tests; Piperidines; Pollen; Rhinitis, Allergic, Perennial; Single-Blind Method; Stem Cell Factor | 1998 |
Onset of action, effectiveness and tolerance of levocabastine and nedocromil in topical therapy of seasonal allergic rhinoconjunctivitis. The Deutsche Rhinitis-Studiengruppe.
Topics: Administration, Intranasal; Adolescent; Adult; Aerosols; Anti-Allergic Agents; Child; Child, Preschool; Conjunctivitis, Allergic; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nedocromil; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal; Time Factors | 1998 |
[Clinical efficacy and safety of levocarbastine++ in the therapy in children suffering from seasonal allergic rhinitis and conjunctivitis who are less than 12 year of age].
Topics: Child; Child, Preschool; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Seasonal | 1998 |
Experimentally induced nasal hypersecretion does not reduce the efficacy of intranasal levocabastine.
Topics: Administration, Intranasal; Adult; Analysis of Variance; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Methacholine Chloride; Nasal Lavage Fluid; Nasal Mucosa; Nasal Provocation Tests; Piperidines; Rhinitis; Sneezing; Statistics, Nonparametric | 1998 |
Lack of effect of erythromycin and ketoconazole on the pharmacokinetics and pharmacodynamics of steady-state intranasal levocabastine.
Topics: Administration, Intranasal; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Area Under Curve; Biological Availability; Bradycardia; Cross-Over Studies; Drug Interactions; Electrocardiography; Erythromycin; Headache; Heart Block; Histamine H1 Antagonists; Humans; Ketoconazole; Male; Middle Aged; Piperidines; Rhinitis; Time Factors; Virus Diseases | 1999 |
Onset and duration of action of levocabastine nasal spray in atopic patients under nasal challenge conditions.
Topics: Administration, Intranasal; Adult; Allergens; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nasal Provocation Tests; Piperidines; Poaceae; Pollen; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Single-Blind Method; Trees | 1999 |
Comparison of the effects of fluticasone propionate, aqueous nasal spray and levocabastine on inflammatory cells in nasal lavage and clinical activity during the pollen season in seasonal rhinitics.
Topics: Administration, Topical; Adolescent; Adult; Androstadienes; Anti-Inflammatory Agents; Double-Blind Method; Eosinophils; Female; Fluticasone; Glucocorticoids; Histamine H1 Antagonists; Humans; Leukocyte Count; Male; Middle Aged; Nasal Lavage Fluid; Piperidines; Pollen; Rhinitis, Allergic, Seasonal | 1999 |
A double-blind, placebo-controlled comparison of treatment with fluticasone propionate and levocabastine in patients with seasonal allergic rhinitis. FLNCO2 Italian Study Group.
Topics: Adult; Androstadienes; Anti-Allergic Agents; Double-Blind Method; Eosinophilia; Female; Fluticasone; Histamine H1 Antagonists; Humans; Hydrocortisone; Male; Piperidines; Rhinitis, Allergic, Seasonal | 1999 |
Rapid onset of action of levocabastine eye-drops in histamine-induced conjunctivitis.
Topics: Adult; Animals; Chick Embryo; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Severity of Illness Index; Time Factors; Treatment Outcome | 1993 |
Safety and efficacy comparison of emedastine 0.05% ophthalmic solution compared to levocabastine 0.05% ophthalmic suspension in pediatric subjects with allergic conjunctivitis. Emadine Study Group.
Topics: Adolescent; Benzimidazoles; Child; Child, Preschool; Conjunctivitis, Allergic; Double-Blind Method; Histamine H1 Antagonists; Humans; Ophthalmic Solutions; Piperidines; Safety; Suspensions | 2000 |
An efficacy and tolerance comparison of emedastine difumarate 0.05% and levocabastine hydrochloride 0.05%: reducing chemosis and eyelid swelling in subjects with seasonal allergic conjunctivitis. Emadine Study Group.
Topics: Adolescent; Adult; Aged; Benzimidazoles; Child; Child, Preschool; Conjunctiva; Conjunctivitis, Allergic; Double-Blind Method; Edema; Eyelid Diseases; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Safety; Seasons; Treatment Outcome | 2000 |
Emedastine ophthalmic solution 0.05% versus levocabastine ophthalmic suspension 0.05% in the treatment of allergic conjunctivitis using the conjunctival allergen challenge model.
Topics: Adolescent; Adult; Aged; Allergens; Benzimidazoles; Conjunctiva; Conjunctivitis, Allergic; Double-Blind Method; Drug Evaluation; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Prospective Studies; Safety; Suspensions; Treatment Outcome | 2000 |
Comparison of azelastine eye drops with levocabastine eye drops in the treatment of seasonal allergic conjunctivitis.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Conjunctivitis, Allergic; Consumer Product Safety; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Medical Records; Middle Aged; Ophthalmic Solutions; Phthalazines; Piperidines; Time Factors | 2000 |
Cost effectiveness of emedastine versus levocabastine in the treatment of allergic conjunctivitis in 7 European countries.
Topics: Benzimidazoles; Conjunctivitis, Allergic; Cost-Benefit Analysis; Double-Blind Method; Health Care Costs; Histamine H1 Antagonists; Humans; Piperidines | 2001 |
Clinical evaluation of twice-daily emedastine 0.05% eye drops (Emadine eye drops) versus levocabastine 0.05% eye drops in patients with allergic conjunctivitis.
Topics: Adolescent; Adult; Aged; Benzimidazoles; Child; Child, Preschool; Conjunctivitis, Allergic; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Middle Aged; Ophthalmic Solutions; Piperidines; Prospective Studies; Pruritus | 2001 |
Comparative efficacy and safety of azelastine and levocabastine nasal sprays in patients with seasonal allergic rhinitis.
Topics: Administration, Intranasal; Adult; Aerosols; Aged; Anti-Allergic Agents; Double-Blind Method; Endpoint Determination; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Phthalazines; Piperidines; Rhinitis, Allergic, Seasonal; Risk Assessment | 2001 |
Nedocromil sodium and levocabastine reduce the symptoms of conjunctival allergen challenge by different mechanisms.
Topics: Adult; Anti-Allergic Agents; Conjunctiva; Conjunctivitis, Allergic; E-Selectin; Female; Histamine; Histamine H1 Antagonists; Humans; Intercellular Adhesion Molecule-1; Lolium; Male; Middle Aged; Nedocromil; Piperidines; Prostaglandin D2; Tears; Vascular Cell Adhesion Molecule-1 | 2001 |
Topical azelastine in perennial allergic conjunctivitis.
Topics: Administration, Topical; Adolescent; Adult; Aged; Analysis of Variance; Anti-Allergic Agents; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Phthalazines; Piperidines; Rhinitis, Allergic, Perennial | 2003 |
Efficacy and safety of ketotifen eye drops in the treatment of seasonal allergic conjunctivitis.
Topics: Anti-Allergic Agents; Conjunctivitis, Allergic; Double-Blind Method; Female; Follow-Up Studies; Histamine H1 Antagonists; Humans; Ketotifen; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Seasons; Secondary Prevention; Treatment Outcome | 2003 |
Randomised double masked trial comparing the efficacy and tolerance of 0.05% mequitazine eye drops versus 0.05% levocabastine and placebo in allergic conjunctivitis induced by a conjunctival provocation test with Dermatophagoides pteronyssinus.
Topics: Adolescent; Adult; Chi-Square Distribution; Conjunctivitis, Allergic; Dermatophagoides pteronyssinus; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Phenothiazines; Piperidines; Statistics, Nonparametric | 2004 |
Efficacy and tolerability of ophthalmic epinastine: a randomized, double-masked, parallel-group, active- and vehicle-controlled environmental trial in patients with seasonal allergic conjunctivitis.
Topics: Adolescent; Adult; Aged; Child; Conjunctivitis, Allergic; Dibenzazepines; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Imidazoles; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal | 2004 |
Comparative efficacy of olopatadine 0.1% ophthalmic solution versus levocabastine 0.05% ophthalmic suspension using the conjunctival allergen challenge model.
Topics: Adolescent; Adult; Aged; Conjunctivitis, Allergic; Dibenzoxepins; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Olopatadine Hydrochloride; Ophthalmic Solutions; Piperidines; Severity of Illness Index; Treatment Outcome | 2004 |
Comparison of allergen immunotherapy and drug treatment in seasonal rhinoconjunctivitis: a 3-years study.
Topics: Administration, Intranasal; Adolescent; Adult; Allergens; Anti-Allergic Agents; Anti-Inflammatory Agents; Cetirizine; Conjunctivitis, Allergic; Desensitization, Immunologic; Drug Therapy, Combination; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Mometasone Furoate; Ophthalmic Solutions; Piperidines; Poaceae; Pollen; Pregnadienediols; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2005 |
[Comparison of three antiallergic eyedrops in a specific conjunctival provocation test: mequitazine, levocabastine and dexamethasone].
Topics: Adult; Allergens; Anti-Allergic Agents; Anti-Inflammatory Agents; Conjunctiva; Conjunctivitis, Allergic; Data Interpretation, Statistical; Dexamethasone; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Phenothiazines; Piperidines; Time Factors | 2005 |
Efficacy, cost-effectiveness, and tolerability of mometasone furoate, levocabastine, and disodium cromoglycate nasal sprays in the treatment of seasonal allergic rhinitis.
Topics: Administration, Intranasal; Adolescent; Adult; Anti-Allergic Agents; Cromolyn Sodium; Eosinophil Cationic Protein; Female; Humans; Male; Middle Aged; Mometasone Furoate; Piperidines; Pregnadienediols; Respiratory Function Tests; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2005 |
Efficacy of levocabastine hydrochloride ophthalmic suspension in the conjunctival allergen challenge test in Japanese subjects with seasonal allergic conjunctivitis.
Topics: Adult; Allergens; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Japan; Male; Ophthalmic Solutions; Piperidines; Seasons; Suspensions; Treatment Outcome | 2006 |
Effect of antihistamine eye drops on the conjunctival provocation test with Japanese cedar pollen allergen.
Topics: Adult; Allergens; Antigens, Plant; Conjunctivitis, Allergic; Cryptomeria; Dose-Response Relationship, Immunologic; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Hyperemia; Japan; Ketotifen; Ophthalmic Solutions; Piperidines; Plant Proteins; Pollen; Premedication; Pruritus; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome | 2006 |
Clinical and biological efficacy of preservative-free NAAGA eye-drops versus levocabastine eye-drops in vernal keratoconjunctivitis patients.
Topics: Anti-Inflammatory Agents; Child; Conjunctivitis, Allergic; Dipeptides; Eosinophil Cationic Protein; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Lymphocyte Count; Male; Ophthalmic Solutions; Osmolar Concentration; Pilot Projects; Piperidines; Preservatives, Pharmaceutical; Tears; Treatment Outcome | 2007 |
The effect of levocabastine and furosemide pretreatment on hyperreactive response after nasal provocation with hypotonic aerosol in subjects with allergic rhinitis.
Topics: Administration, Intranasal; Adolescent; Adult; Diuretics; Female; Furosemide; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Nasal Obstruction; Nasal Provocation Tests; Piperidines; Rhinitis, Allergic, Perennial; Rhinomanometry; Saline Solution, Hypertonic; Time Factors; Young Adult | 2007 |
The effect of a combined therapy with a histamine H1 antagonist and a chemical mediator release inhibitor on allergic conjunctivitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Conjunctivitis, Allergic; Drug Therapy, Combination; Eosinophils; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukocyte Count; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Pyridines; Pyrimidinones; Treatment Outcome | 2008 |
[Intra-annual and seasonal allergic conjunctivitis treatment: comparison of two therapeutic protocols].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Child; Child, Preschool; Clinical Protocols; Conjunctivitis, Allergic; Dipeptides; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Piperidines; Prospective Studies; Seasons; Young Adult | 2008 |
A multicenter randomized double-blind 2-week comparison study of azelastine nasal spray 0.1% versus levocabastine nasal spray 0.05% in patients with moderate-to-severe allergic rhinitis.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Nasal Sprays; Phthalazines; Piperidines; Retrospective Studies; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome; Young Adult | 2011 |
[Safety and efficacy of a new preservative-free levocabastine ophthalmic solution (Levofree®) using the conjunctival provocation test].
Topics: Administration, Ophthalmic; Adolescent; Adult; Allergens; Chemistry, Pharmaceutical; Conjunctiva; Conjunctivitis, Allergic; Diagnostic Techniques, Ophthalmological; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Preservatives, Pharmaceutical; Treatment Outcome; Young Adult | 2012 |
The improved efficacy of a fixed-dose combination of fluticasone furoate and levocabastine relative to the individual components in the treatment of allergic rhinitis.
Topics: Adolescent; Adult; Aged; Androstadienes; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic | 2015 |
Once-daily dosing of levocabastine has comparable efficacy to twice-daily dosing in the treatment of allergic rhinitis assessed in an allergen challenge chamber.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic; Young Adult | 2015 |
Pharmacokinetics, Safety, and Tolerability of Once-Daily Intranasal Fluticasone Furoate and Levocabastine Administered Alone or Simultaneously as fluticasone Furoate/Levocabastine Fixed-Dose Combination.
Topics: Administration, Intranasal; Adult; Androstadienes; Biological Availability; Cross-Over Studies; Drug Combinations; Female; Glucocorticoids; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle Aged; Piperidines; Young Adult | 2016 |
87 other study(ies) available for levocabastine and piperidines
| Article | Year |
|---|---|
Levocabastine: pharmacological profile of a highly effective inhibitor of allergic reactions.
Topics: Anaphylaxis; Animals; Ascaris; Conjunctivitis, Allergic; Dogs; Guinea Pigs; Histamine; Histamine H1 Antagonists; Hypersensitivity; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Piperidines; Rats | 1992 |
Influence of levocabastine suspension on ciliary beat frequency and mucociliary clearance.
Topics: Adenoids; Adult; Cilia; Epithelium; Histamine H1 Antagonists; Humans; In Vitro Techniques; Middle Aged; Mucociliary Clearance; Nasal Mucosa; Piperidines | 1992 |
Regional characterization of brain neurotensin receptor subtypes in LS and SS mice.
Topics: Alcohol Drinking; Animals; Binding, Competitive; Brain; Chlorpheniramine; Haloperidol; Histamine H1 Antagonists; Male; Mice; Mice, Inbred Strains; Neurotensin; Piperidines; Receptors, Neurotensin; Receptors, Neurotransmitter; Sleep Stages; Species Specificity | 1991 |
Inhibitory effect of levocabastine on experimental allergic conjunctivitis in guinea pigs.
Topics: Aminopyridines; Animals; Antigens; Capillary Permeability; Conjunctivitis, Allergic; Cromolyn Sodium; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Histidine Decarboxylase; Male; Piperidines; SRS-A | 1991 |
Central effect of the potent long-acting H1-antihistamine levocabastine.
Topics: Acetates; Animals; Avoidance Learning; Central Nervous System; Electroencephalography; Histamine H1 Antagonists; Male; Mice; Mice, Inbred Strains; Motor Activity; Oxotremorine; Pain; Piperidines; Rats; Rats, Inbred Strains; Salivation; Sleep; Thiopental; Tremor | 1990 |
Further characterization of neurotensin binding in the rat brain: levocabastine-displaceable neurotensin binding sites are not histamine-H1 receptors.
Topics: Animals; Binding Sites; Brain; Guinea Pigs; Neurotensin; Piperidines; Rats; Receptors, Histamine H1 | 1989 |
Application of histamine-induced conjunctivitis to the assessment of a topical antihistamine, levocabastine.
Topics: Administration, Topical; Animals; Conjunctivitis, Allergic; Drug Evaluation, Preclinical; Guinea Pigs; Histamine; Histamine H1 Antagonists; Piperidines | 1987 |
Two populations of neurotensin binding sites in murine brain: discrimination by the antihistamine levocabastine reveals markedly different radioautographic distribution.
Topics: Animals; Autoradiography; Brain Chemistry; Cell Membrane; Histamine H1 Antagonists; In Vitro Techniques; Male; Piperidines; Rabbits; Rats; Receptors, Neurotensin; Receptors, Neurotransmitter; Temperature | 1987 |
Heterogeneity of [3H]neurotensin bindings: studies with dynorphin, L-156,903 and levocabastine.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Dynorphins; Female; In Vitro Techniques; Male; Neurotensin; Oligopeptides; Phenothiazines; Piperidines; Rats; Rats, Inbred Strains | 1988 |
Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain.
Topics: Animals; Binding, Competitive; Brain; Cats; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Mice; Neurotensin; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurotensin; Receptors, Neurotransmitter | 1986 |
Levocabastine. Evaluation in the histamine and compound 48/80 models of ocular allergy in humans.
Topics: Conjunctivitis, Allergic; Histamine; Humans; p-Methoxy-N-methylphenethylamine; Piperidines | 1988 |
Opposite regulation of serotonin-S2 and dopamine-D2 receptors in rat brain following chronic receptor blockade.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Diazepam; Dopamine Antagonists; Frontal Lobe; Gene Expression Regulation; Ketanserin; Male; Models, Biological; Piperidines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists; Tryptamines | 1987 |
Antiallergic profile of the novel H1-antihistaminic compound levocabastine.
Topics: Anaphylaxis; Animals; Chemotaxis, Leukocyte; Complement Inactivator Proteins; Cyclic AMP; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Hypersensitivity; Immunoglobulin E; In Vitro Techniques; Lung; Male; Mast Cells; Mice; Mice, Inbred BALB C; Muscle, Smooth; Piperidines; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Rats, Wistar; Skin Tests | 1993 |
Effects of antiallergic agents including levocabastine on experimental rhinitis in rats.
Topics: Acetylcholine; Animals; Antigens, Helminth; Ascaris; Histamine; Histamine H1 Antagonists; Ketotifen; Male; Nasal Mucosa; Piperidines; Platelet Activating Factor; Rats; Rats, Wistar; Rhinitis; Substance P | 1994 |
Nonsteroidal eye drops for ocular allergy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Allergic; Drug Combinations; Histamine H1 Antagonists; Humans; Ketorolac Tromethamine; Ophthalmic Solutions; Oxamic Acid; Piperidines; Tolmetin; Tromethamine | 1994 |
Characterization of neurotensin-stimulated phosphoinositide hydrolysis in brain regions of long sleep and short sleep mice.
Topics: Animals; Brain; Calcium; Carbachol; Cerebellum; Dose-Response Relationship, Drug; Hippocampus; Histamine H1 Antagonists; Hydrolysis; Inositol; Inositol Phosphates; Kinetics; Membrane Lipids; Mesencephalon; Mice; Mice, Inbred Strains; Neurotensin; Nucleus Accumbens; Organ Specificity; Phosphatidylinositols; Phospholipids; Piperidines; Receptors, Neurotensin; Second Messenger Systems; Sleep | 1993 |
Pharmacokinetics of orally administered levocabastine in patients with renal insufficiency.
Topics: Adult; Female; Half-Life; Histamine H1 Antagonists; Humans; Kidney Failure, Chronic; Male; Middle Aged; Piperidines; Renal Dialysis | 1993 |
Ophthalmic levocabastine for allergic conjunctivitis.
Topics: Clinical Trials as Topic; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Ophthalmic Solutions; Piperidines | 1994 |
Topical update: new medications for ocular allergy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Ophthalmic Solutions; Oxamic Acid; Piperidines; United States; United States Food and Drug Administration | 1994 |
Chronic ethanol administration downregulates neurotensin receptors in long- and short-sleep mice.
Topics: Animals; Benzamides; Benzazepines; Down-Regulation; Ethanol; Histamine H1 Antagonists; Kinetics; Male; Membranes; Mesencephalon; Mice; Mice, Inbred Strains; Neural Pathways; Neurotensin; Piperidines; Pyrrolidines; Receptors, Dopamine D1; Receptors, Neurotensin; Receptors, Neurotransmitter; Sleep; Species Specificity | 1993 |
[Levocabastine--a new antihistaminic for local treatment].
Topics: Administration, Intranasal; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Ophthalmic Solutions; Piperidines; Rhinitis, Allergic, Seasonal | 1993 |
Selective effect of levocabastine on histamine receptor and histamine release from human leukocytes and guinea pig isolated tissue.
Topics: Adult; Animals; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity; Interleukin-5; Leukocytes; Lung; Middle Aged; Muscle Contraction; Muscle, Smooth; Piperidines; Receptors, Histamine H1; Trachea | 1996 |
Molecular cloning of a levocabastine-sensitive neurotensin binding site.
Topics: Amino Acid Sequence; Animals; Cell Line; Chlorocebus aethiops; Hypothalamus; Molecular Sequence Data; Piperidines; Rats; Receptors, Neurotensin; RNA, Messenger; Sequence Homology, Amino Acid; Tissue Distribution | 1996 |
Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Histamine H1 Antagonists; Humans; Mice; Molecular Sequence Data; Neurotensin; Peptide Fragments; Piperidines; Rats; Receptors, Neurotensin; RNA, Messenger; Structure-Activity Relationship; Tissue Distribution; Xenopus laevis | 1996 |
Human conjunctival epithelial cells express histamine-1 receptors coupled to phosphoinositide turnover and intracellular calcium mobilization: role in ocular allergic and inflammatory diseases.
Topics: Benzimidazoles; Calcium; Cells, Cultured; Chromatography, Ion Exchange; Conjunctiva; Cytokines; Epithelium; Eye Diseases; Histamine; Histamine Antagonists; Humans; Hypersensitivity; Inflammation; Phosphatidylinositols; Piperidines; Receptors, Histamine H1; Stimulation, Chemical; Triprolidine | 1996 |
Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; COS Cells; DNA, Complementary; Gene Expression; Genetic Variation; Mice; Molecular Sequence Data; Neurotensin; Piperidines; Receptors, Neurotensin | 1997 |
[Rhinoconjunctivitis. Highly selective therapy using topical H1-blockers].
Topics: Anti-Allergic Agents; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Nedocromil; Piperidines; Rhinitis, Allergic, Perennial | 1996 |
Differential binding profile and internalization process of neurotensin via neuronal and glial receptors.
Topics: Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Endocytosis; GTP-Binding Proteins; Mesencephalon; Nerve Tissue Proteins; Neuroglia; Neurons; Neurotensin; Piperidines; Protein Binding; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Signal Transduction; Tegmentum Mesencephali; Tyrosine 3-Monooxygenase | 1997 |
Effects of SR 48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system: agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine insensi
Topics: Animals; Calcium; Chlorides; Electric Conductivity; Female; Mice; Neurotensin; Oocytes; Piperidines; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin | 1997 |
Adsorption of levocabastine eye drops by soft contact lenses and its effects in rabbit eyes.
Topics: Adsorption; Animals; Benzalkonium Compounds; Chromatography, High Pressure Liquid; Contact Lenses, Hydrophilic; Cornea; Drug Evaluation; Follow-Up Studies; Histamine H1 Antagonists; Ophthalmic Solutions; Piperidines; Preservatives, Pharmaceutical; Rabbits | 1997 |
Effects of non-steroidal antiallergic eyedrops on the complement-mediated histamine release from human cells.
Topics: Allergens; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Basophil Degranulation Test; Basophils; Cell Degranulation; Complement C5; Cromolyn Sodium; Dipeptides; Enzyme-Linked Immunosorbent Assay; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity, Immediate; Ophthalmic Solutions; Oxamic Acid; Piperidines; Recombinant Proteins | 1997 |
Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Endocytosis; Gene Expression Regulation; Humans; Iodine Radioisotopes; Kinetics; Mice; Molecular Sequence Data; Neurotensin; Peptides; Photoaffinity Labels; Piperidines; Protein Binding; Receptors, Neurotensin; Signal Transduction; Transfection | 1998 |
In vivo studies with low doses of levocabastine and diphenhydramine, but not pyrilamine, antagonize neurotensin-mediated antinociception.
Topics: Animals; Body Temperature Regulation; Diphenhydramine; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Male; Mice; Neurotensin; Pain; Piperidines; Pyrilamine; Rats; Rats, Sprague-Dawley | 1998 |
Characterization of binding sites of a new neurotensin receptor antagonist, [3H]SR 142948A, in the rat brain.
Topics: Adamantane; Animals; Autoradiography; Binding Sites; Brain; Imidazoles; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Tritium | 1998 |
[Effect of topical corticosteroids and topical antihistaminics on ciliary epithelium of human nasal mucosa in vitro].
Topics: Administration, Topical; Androstadienes; Anti-Inflammatory Agents; Benzalkonium Compounds; Budesonide; Fluticasone; Glucocorticoids; Histamine H1 Antagonists; Humans; In Vitro Techniques; Mucociliary Clearance; Nasal Mucosa; Phthalazines; Piperidines; Preservatives, Pharmaceutical | 1998 |
Distinct functional characteristics of levocabastine sensitive rat neurotensin NT2 receptor expressed in Chinese hamster ovary cells.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Neurotensin; Oligopeptides; Piperidines; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Signal Transduction; Transfection | 1998 |
Tissue distribution and cellular localization of the levocabastine-sensitive neurotensin receptor mRNA in adult rat brain.
Topics: Animals; Brain; Brain Stem; Cerebellum; Histamine H1 Antagonists; In Situ Hybridization; Male; Oligonucleotide Probes; Piperidines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; RNA, Messenger; Tissue Distribution | 1998 |
X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist.
Topics: Animals; Crystallography, X-Ray; Mice; Models, Molecular; Piperidines; Protein Conformation; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin | 1998 |
Differential ontogenetic patterns of levocabastine-sensitive neurotensin NT2 receptors and of NT1 receptors in the rat brain revealed by in situ hybridization.
Topics: Amygdala; Animals; Brain Chemistry; Cerebellum; Cerebral Cortex; Cerebral Ventricles; Ependyma; Gene Expression Regulation, Developmental; Hippocampus; Histamine H1 Antagonists; In Situ Hybridization; Male; Mesencephalon; Nerve Fibers; Neuroglia; Neurons; Piperidines; Pons; Prosencephalon; Rats; Rats, Wistar; Receptors, Neurotensin; RNA, Messenger | 1999 |
Neurotensin receptors and dopamine transporters: effects of MPTP lesioning and chronic dopaminergic treatments in monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adamantane; Animals; Autoradiography; Binding Sites; Carrier Proteins; Caudate Nucleus; Denervation; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Down-Regulation; Imidazoles; In Situ Hybridization; Macaca fascicularis; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Neurotensin; Piperidines; Putamen; Receptors, Dopamine; Receptors, Neurotensin; RNA, Messenger; Substantia Nigra | 1999 |
Neurotensin receptors in human neoplasms: high incidence in Ewing's sarcomas.
Topics: Animals; Bone Neoplasms; Humans; Neoplasm Proteins; Neoplasms; Neurotensin; Organ Specificity; Peptide Fragments; Piperidines; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; RNA, Messenger; RNA, Neoplasm; Sarcoma, Ewing | 1999 |
The partial agonist properties of levocabastine in neurotensin-induced analgesia.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Male; Mice; Neurotensin; Pain; Pain Threshold; Piperidines; Pyrilamine; Receptors, Neurotensin | 1999 |
Neurotensin depolarizes cholinergic and a subset of non-cholinergic septal/diagonal band neurons by stimulating neurotensin-1 receptors.
Topics: Action Potentials; Adamantane; Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine H1 Antagonists; Imidazoles; In Vitro Techniques; Male; Membrane Potentials; Neurons; Neurotensin; Patch-Clamp Techniques; Piperidines; Prosencephalon; Receptors, Neurotensin; Tetrodotoxin | 1999 |
Effects of levocabastine on lipid mediator release from guinea pig lung fragments.
Topics: Animals; Antigens; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Leukotriene C4; Leukotriene E4; Lung; Male; Piperidines; Thromboxane B2 | 1999 |
Neurotensin regulates intracellular calcium in ventral tegmental area astrocytes: evidence for the involvement of multiple receptors.
Topics: Adamantane; Animals; Animals, Newborn; Astrocytes; Calcium; Cells, Cultured; Estrenes; Gadolinium; Imidazoles; Neurotensin; Peptide Fragments; Piperidines; Pyrrolidinones; Rats; Receptors, Neurotensin; Thapsigargin; Type C Phospholipases; Ventral Tegmental Area | 2000 |
Neurotensin inhibits neuronal Na+,K+-ATPase activity through high affinity peptide receptor.
Topics: Animals; Cerebral Cortex; Heating; In Vitro Techniques; Intracellular Membranes; Male; Neurotensin; Piperidines; Rats; Rats, Wistar; Receptors, Neurotensin; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 2000 |
Localization of neurotensin NTS2 receptors in rat brain, using.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Histamine H1 Antagonists; Male; Neurotensin; Piperidines; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin | 2001 |
Involvement of the neurotensin receptor subtype NTR3 in the growth effect of neurotensin on cancer cell lines.
Topics: Animals; Cell Membrane; CHO Cells; Cholic Acids; Colonic Neoplasms; Cricetinae; Drug Resistance, Neoplasm; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Male; Neurotensin; Pancreatic Neoplasms; Piperidines; Prostatic Neoplasms; Protein Binding; Protein Structure, Tertiary; Receptors, Neurotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection; Tumor Cells, Cultured | 2001 |
Characterization and autoradiographic localization of neurotensin binding sites in human sigmoid colon.
Topics: Adult; Aged; Autoradiography; Binding, Competitive; Colon, Sigmoid; Dose-Response Relationship, Drug; Enteric Nervous System; Female; Histamine H1 Antagonists; Humans; In Vitro Techniques; Iodine Radioisotopes; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurotensin; Peptide Fragments; Phenanthrolines; Piperidines; Protease Inhibitors; Receptors, Neurotensin; Tetrodotoxin | 2001 |
Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Topics: Amino Acid Sequence; Animals; COS Cells; Histamine H1 Antagonists; Humans; Molecular Sequence Data; Neurotensin; Piperidines; Pyrazoles; Quinolines; Receptors, Neurotensin; Sequence Homology, Amino Acid; Transfection | 2001 |
Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors.
Topics: Animals; Cobalt; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Glutamine; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neostriatum; Nerve Tissue Proteins; Neurons; Neurotensin; Phosphoproteins; Phosphorylation; Piperidines; Pyrazoles; Quinolines; Receptors, Dopamine D1; Receptors, Neurotensin; Signal Transduction; Tetrodotoxin | 2002 |
Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells.
Topics: Binding, Competitive; Cell Division; Cytochalasin D; Dose-Response Relationship, Drug; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lung Neoplasms; Neurotensin; Nucleic Acid Synthesis Inhibitors; Peptide Fragments; Phosphorylation; Piperidines; Protein-Tyrosine Kinases; Pyrazoles; Quinolines; Receptors, Neurotensin; Tumor Cells, Cultured; Tyrosine | 2002 |
Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells.
Topics: Aniline Compounds; Animals; Binding Sites; Binding, Competitive; Calcium; Cerebellum; Clathrin; Cytosol; Dose-Response Relationship, Drug; Fluorescent Dyes; Histamine H1 Antagonists; Inhibitory Concentration 50; Male; Microscopy, Confocal; Piperidines; Polymerase Chain Reaction; Protein Binding; Pyrazoles; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Neurotensin; Receptors, Presynaptic; Reverse Transcriptase Polymerase Chain Reaction; RNA; Time Factors; Xanthenes | 2002 |
[The curative effect of livostin spray on treating allergic rhinitis of children].
Topics: Administration, Intranasal; Adolescent; Aerosols; Child; Child, Preschool; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Perennial | 2001 |
[In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].
Topics: Air Pollutants; Anti-Allergic Agents; Benzalkonium Compounds; Benzimidazoles; Complement Activation; Conjunctivitis; Cosmetics; Dibenzoxepins; Dipeptides; Drug Evaluation; Dust; Humans; In Vitro Techniques; Ketotifen; Nedocromil; Olopatadine Hydrochloride; Ophthalmic Solutions; Oxamic Acid; Phthalazines; Piperidines; Pollen; Silicon Dioxide; Zymosan | 2003 |
Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Benzazepines; Dizocilpine Maleate; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Histamine H1 Antagonists; Immunoblotting; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Neostriatum; Nerve Tissue Proteins; Neurons; Neurotensin; Phosphoproteins; Piperidines; Pyrazoles; Quinolines; Raclopride; Receptors, Neurotensin; Signal Transduction; Tetrodotoxin; Threonine; Time Factors | 2003 |
[Report on the results of examination of patients suspected of disseminated sclerosis in the districts of Duchcov and Bilina].
Topics: Biometry; Humans; Multiple Sclerosis; Piperidines | 1962 |
Beta-lactotensin and neurotensin rapidly reduce serum cholesterol via NT2 receptor.
Topics: Animals; Cholesterol; Dopamine Antagonists; Male; Mice; Mice, Inbred ICR; Neurotensin; Oligopeptides; Piperidines; Raclopride; Receptors, Neurotensin | 2003 |
Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2.
Topics: Animals; Base Sequence; Calcium; CHO Cells; Cricetinae; DNA Primers; Enzyme Activation; Histamine H1 Antagonists; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurotensin; Piperidines; Rats; Receptors, Neurotensin; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2004 |
Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Western; Brain; Cell Line; Central Nervous System; CHO Cells; COS Cells; Cricetinae; Densitometry; Dimerization; DNA, Complementary; Dose-Response Relationship, Drug; Epitopes; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Inhibitory Concentration 50; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; Neurotensin; Peptides; Piperidines; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Rats; Receptors, Neurotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Spinal Cord; Time Factors; Tissue Distribution; Transfection | 2005 |
Increasing effect by simultaneous use of levocabastine and pemirolast on experimental allergic conjunctivitis in rats.
Topics: Animals; Conjunctivitis, Allergic; Drug Synergism; Drug Therapy, Combination; Histamine Release; Male; Piperidines; Pyridines; Pyrimidinones; Rats; Rats, Wistar | 2005 |
Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat.
Topics: Anaphylaxis; Animals; Capillary Permeability; Conjunctivitis, Allergic; Dibenzoxepins; Disease Models, Animal; Edema; Eyelids; Guinea Pigs; Histamine H1 Antagonists; Ketotifen; Male; Olopatadine Hydrochloride; Ophthalmic Solutions; Ovalbumin; Piperidines; Rats | 2005 |
Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors.
Topics: Analgesics; Animals; Ganglia, Spinal; Hot Temperature; In Vitro Techniques; Injections, Spinal; Lumbar Vertebrae; Models, Animal; Neurotensin; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Spinal Cord; Tail | 2005 |
Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Histamine H1 Antagonists, Non-Sedating; Injections, Intraventricular; Ligands; Male; Mice; Morphine; Neurotensin; Pain Threshold; Piperidines; Pyrazoles; Quinolines; Reaction Time; Receptors, Neurotensin; Receptors, Opioid | 2006 |
The early efficacy of topical levocabastine in patients with allergic conjunctivitis.
Topics: Administration, Topical; Adult; Aged; Conjunctivitis, Allergic; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Treatment Outcome | 2006 |
Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine.
Topics: Animals; Anti-Allergic Agents; Cells, Cultured; Chlorpheniramine; Guinea Pigs; Histamine H1 Antagonists, Non-Sedating; Humans; Integrin alpha4beta1; Jurkat Cells; Male; Piperidines; Protein Binding | 2008 |
The effect of levocabastine hydrochloride on human Tenon's capsule fibroblasts: inhibition of proliferation, suppression of DNA synthesis and induction of apoptosis.
Topics: Aged; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Conjunctiva; DNA; Dose-Response Relationship, Drug; Fibroblasts; Histamine H1 Antagonists, Non-Sedating; Humans; Ketotifen; Male; ortho-Aminobenzoates; Piperidines | 2009 |
Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity.
Topics: Animals; Formaldehyde; Histamine H1 Antagonists, Non-Sedating; Inflammation; Male; Neurotensin; Pain; Peptide Fragments; Piperidines; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Spinal Nerves; Time Factors | 2009 |
NT69L, a novel analgesic, shows synergy with morphine.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Male; Morphine; Neurotensin; Pain; Pain Measurement; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Time Factors | 2009 |
beta-Lactotensin derived from bovine beta-lactoglobulin suppresses food intake via the CRF system followed by the CGRP system in mice.
Topics: Animals; Corticotropin-Releasing Hormone; Eating; Lactoglobulins; Male; Mice; Oligopeptides; Peptide Fragments; Piperidines; Receptors, Neurotensin | 2009 |
[Effect of intra nasally applied fluticasone propionate and levocabastine on the expression of aquaporin 5 in nasal mucosa of rat with experimental allergic rhinitis].
Topics: Androstadienes; Animals; Aquaporin 5; Fluticasone; Nasal Mucosa; Piperidines; Rats; Rats, Wistar; Rhinitis, Allergic, Perennial | 2009 |
Neurotensin is a regulator of insulin secretion in pancreatic beta-cells.
Topics: Animals; Calcium Signaling; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cytoprotection; Enzyme Activation; Insulin; Insulin Secretion; Insulin-Secreting Cells; Neurotensin; Piperidines; Protein Kinase C-alpha; Protein Kinase C-epsilon; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin | 2010 |
Relation between cooling sheet effect and tear histamine concenration in allergic conjunctivitis.
Topics: Conjunctivitis, Allergic; Cryotherapy; Enzyme-Linked Immunosorbent Assay; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Ophthalmic Solutions; Piperidines; Pruritus; Severity of Illness Index; Tears | 2010 |
β-Lactotensin derived from bovine β-lactoglobulin exhibits anxiolytic-like activity as an agonist for neurotensin NTS(2) receptor via activation of dopamine D(1) receptor in mice.
Topics: Animals; Anti-Anxiety Agents; Astrocytes; Behavior, Animal; Calcium; Cattle; Cells, Cultured; Cerebral Cortex; Dopamine Antagonists; Drug Administration Routes; Drug Interactions; Exploratory Behavior; Glutamic Acid; Lactoglobulins; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Piperidines; Receptors, Dopamine D2; Receptors, Neurotensin; Time Factors | 2011 |
Neurotensin decreases high affinity [3H]-ouabain binding to cerebral cortex membranes.
Topics: Animals; Cerebral Cortex; Male; Neurotensin; Ouabain; Piperidines; Protein Binding; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin | 2011 |
Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn.
Topics: Animals; Benzophenanthridines; Excitatory Postsynaptic Potentials; Glutamic Acid; Neurotensin; Oligopeptides; Patch-Clamp Techniques; Pertussis Toxin; Piperidines; Posterior Horn Cells; Potassium Channels; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Signal Transduction; Synapses; Synaptic Transmission | 2011 |
In vivo investigations of neurotensin receptors in adipocytes, hepatocytes and enterocytes of rat.
Topics: Adipocytes; Adipose Tissue; Animals; Antigen-Antibody Reactions; Cell Membrane; Enterocytes; Hepatocytes; Histamine H1 Antagonists, Non-Sedating; Intestine, Small; Iodine Radioisotopes; Isotope Labeling; Liver; Male; Neurotensin; Piperidines; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin | 2011 |
NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain.
Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; Behavior, Animal; Histamine H1 Antagonists; Mice; Mice, Knockout; Neurotensin; Pain; Pain Measurement; Peptide Fragments; Piperidines; Receptors, Neurotensin | 2012 |
Spinal NTS2 receptor activation reverses signs of neuropathic pain.
Topics: Analgesics; Animals; Blotting, Western; Ganglia, Spinal; Male; Microscopy, Electron, Transmission; Neuralgia; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Spinal Cord | 2013 |
Evaluation of allergic conjunctivitis by thermography.
Topics: Adult; Allergens; Body Temperature; Conjunctiva; Conjunctivitis, Allergic; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Ophthalmic Solutions; Piperidines; Thermography; Young Adult | 2014 |
In vitro effects of preserved and unpreserved anti-allergic drugs on human corneal epithelial cells.
Topics: Anti-Allergic Agents; Benzalkonium Compounds; Cell Survival; Cells, Cultured; Dibenzoxepins; Electric Impedance; Epithelial Cells; Epithelium, Corneal; Humans; In Vitro Techniques; Ketotifen; Olopatadine Hydrochloride; Ophthalmic Solutions; Piperidines; Preservatives, Pharmaceutical | 2014 |
The Administration of Levocabastine, a NTS2 Receptor Antagonist, Modifies Na(+), K(+)-ATPase Properties.
Topics: Animals; Cerebral Cortex; Male; Ouabain; Piperidines; Protein Binding; Rats; Rats, Wistar; Receptors, Neurotensin; Sodium-Potassium-Exchanging ATPase | 2016 |
Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bacterial Proteins; Basolateral Nuclear Complex; Clozapine; Extinction, Psychological; Fear; Gene Expression Regulation; Genes, Reporter; Injections, Intraventricular; Integrases; Intercellular Signaling Peptides and Proteins; Luminescent Proteins; Memory; Mice; Oligopeptides; Optogenetics; Piperidines; Prefrontal Cortex; Receptors, Neurotensin; Sensory Receptor Cells; Sequence Analysis, RNA; Stereotaxic Techniques; Thrombospondins; Thy-1 Antigens; Wnt Proteins | 2016 |
The low affinity neurotensin receptor antagonist levocabastine impairs brain nitric oxide synthesis and mitochondrial function by independent mechanisms.
Topics: Animals; Brain; Histamine H1 Antagonists, Non-Sedating; Male; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Piperidines; Rats; Rats, Wistar; Receptors, Neurotensin | 2017 |
Practical and Sustainable Synthesis of Optically Pure Levocabastine, a H₁ Receptor Antagonist.
Topics: Histamine H1 Antagonists; Molecular Structure; Piperidines | 2017 |
Biophysical insight into the interaction of levocabastine with human serum albumin: spectroscopy and molecular docking approach.
Topics: Binding Sites; Circular Dichroism; Humans; Molecular Docking Simulation; Piperidines; Protein Binding; Serum Albumin, Human; Spectrometry, Fluorescence; Thermodynamics | 2021 |
Changes in synaptic proteins of the complex PSD-95/NMDA receptor/nNOS and mitochondrial dysfunction after levocabastine treatment.
Topics: Adenosine Triphosphate; Animals; Disks Large Homolog 4 Protein; Histamine H1 Antagonists; Male; Membrane Potential, Mitochondrial; Mitochondrial Membranes; Nitric Oxide Synthase Type II; Oxygen Consumption; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptosomes | 2021 |