levetiracetam has been researched along with cytisine* in 1 studies
1 other study(ies) available for levetiracetam and cytisine
| Article | Year |
|---|---|
Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Cytisine (CYT) is a partial agonist of brain α4β2 nicotinic acetylcholine receptors widely used in Central/Eastern Europe for smoking cessation.. This study evaluated the effect of CYT on the ability of classical and novel antiepileptic drugs to prevent seizures evoked by the 6-Hz test, a model of psychomotor seizures in mice thought as a model of drug-resistant seizures.. CYT administered intraperitoneally (i.p.) in a dose of 2 mg kg. CYT-evoked alterations in the protection provided by some antiepileptic drugs against seizures can be of serious concern for epileptic smokers, who might demonstrate therapeutic failure to lacosamide, levetiracetam, and pregabalin, resulting in possible breakthrough seizure attacks. Topics: Alkaloids; Animals; Anticonvulsants; Azocines; Dose-Response Relationship, Drug; Electroshock; Levetiracetam; Male; Memory, Long-Term; Mice; Nicotinic Agonists; Phenobarbital; Piracetam; Quinolizines; Seizures; Valproic Acid | 2017 |