Page last updated: 2024-08-25

leupeptin and pepstatin

leupeptin has been researched along with pepstatin in 72 studies

Research

Studies (72)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (26.39)	18.7374
1990's	28 (38.89)	18.2507
2000's	22 (30.56)	29.6817
2010's	2 (2.78)	24.3611
2020's	1 (1.39)	2.80

Authors

Authors	Studies
Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ	2
Charris, J; Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ	1
Alvarez-Larena, A; Andujar, S; Barazarte, A; Camacho, J; Capparelli, MV; Charris, J; Domínguez, J; Enriz, D; Gamboa, N; Lobo, G; Rodrigues, J	1
Desai, SA; Fay, MP; Furuya, T; Gluzman, IY; Goldberg, DE; Kambhampati, S; Lisk, G; Pain, M; Su, XZ	1
Alvarez-Larena, A; Barazarte, A; Capparelli, MV; Charris, JE; Gamboa, N; Lobo, G; López, SE; Rodrigues, JR	1
Barazarte, A; Camacho, J; Charris, J; Gamboa, N; Gilman, R; Rodrigues, J; Rojas, R; Vaisberg, A	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Diment, S; Rodriguez, GM	1
Morton, PA; Owensby, DA; Schwartz, AL; Underhill, DM	1
Legaard, PK; LeGrand, RD; Misfeldt, ML	1
Choudhuri, S; Klaassen, CD; McKim, JM	1
Diment, S	1
Katunuma, N; Kominami, E; Muno, D; Ueno, T	1
Bittar, EE; Huang, YP	1
Horiuchi, S; Inokuchi, T; Kobayashi, KI	1
Fridman, R; Hamilton, TC; Kanemoto, T; Martin, GR	1
Olaya, P; Wasserman, M	1
Grisolía, S; Hernández-Yago, J; Knecht, E; Vargas, JL	1
Sano, M; Seto, A; Tsukimura, T; Yamazaki, A	1
Atwood, HL; Boegman, RJ; Scarth, B	1
Lozano, JA; Martinez, JH; Solano, F	1
Kurita, Y; Nakao, H; Ogawa, H; Takamori, K; Tsuboi, R	1
Bureau, TE; Fosket, DE; Morejohn, LC	1
Mykles, DL; Skinner, DM	1
Goto, I; Kuroiwa, Y; Shinno, N	1
Fukuyo, T; Hara, S; Hayasaka, S; Mizuno, K; Nakazawa, M	1
Grimmecke, HD; Schönborn, C; Wand, H	1
Taurog, A; Yoshinari, M	1
Ishiura, S; Kamakura, K; Sano, M; Sugita, H	1
Fukuyo, T; Hayasaka, S; Mizuno, K	1
Banerjee, A; Burg, J; Sandhoff, K	1
Brown, NA; Freeman, SJ	1
Berg, RA; Crystal, RG; Rome, LH; Schwartz, ML	1
Cockle, SM; Dean, RT	2
Berg, RA; Neblock, DS	1
Mego, JL	1
Bourrie, BJ; Casellas, P; Gros, P; Jansen, FK	1
Bowden, SJ; Hughes, SV; Hutchesson, AC; Ratcliffe, WA	1
Horii, I; Koyama, J; Nomura, J; Suzuki, Y	1
Cha, SH; Choi, DS; Kim, YB; Park, YK; Sok, DE	1
Evers, M; Heine, L; Hess, B; Hetman, M; Köster, A; Mossmann, H; Saftig, P; Schmahl, W; von Figura, K; Weber, K	1
Rosenthal, PJ	1
Claeys, E; Demeyer, D; Uytterhaegen, L	1
Constable, IJ; Kennedy, CJ; Papadimitriou, JM; Rakoczy, PE; Robertson, TA	1
Dagouassat, N; Garreau, I; Piot, JM; Sannier, F; Zhao, Q	1
Schnellmann, RG; Yang, X	1
Cabart, P; Jandová, D; Kalousek, I	1
Fujishima, M; Ikenoue, H; Kuroda, T; Okamura, K; Okazawa, K; Sato, K; Yoshinari, M	1
Bettaïeb, A; Jaffrézou, JP; Laurent, G; Levade, T; Mansat, V	1
Hamazaki, H	1
Abrams, WR; Billings, PC; Davis, C; Friedman, H; Kennedy, S; Malamud, D; Nagashunmugam, T	1
Hiroi, Y; Ohshita, T	1
Elliott, JF; Nepom, G; Reijonen, H; van Endert, P	1
Kataoka, H; Kita, T; Kume, N; Masaki, T; Minami, M; Murase, T; Sawamura, T	1
Piotrowski, J; Slomiany, A; Slomiany, BL	1
Bergmann, C; Del Val, M; Gil-Torregrosa, BC; López, D	1
Patterson, MF; Stephenson, DG	1
O'Brien, PJ; Pourahmad, J; Ross, S	1
Biswal, SS; Datta, K; Kehrer, JP	1
Hayashi, Y; Inoue, H; Kizu, Y; Mizuno, F; Ono, M; Saito, I; Takada, K; Tsubota, K; Yamada, K; Yanagi, K	1
Ito, T; Kumamoto, T; Sugihara, R; Toyoshima, I; Tsuda, T; Ueyama, H	1
Curran, PK; Dunigan, CD; Fishman, PH; Hoang, Q	1
Hansen, PJ; Tekin, S	1
Aharon, M; Dvilansky, A; Nathan, I; Shpilberg, O	1
Fujisaki, K; Islam, KM; Kamio, T; Miyoshi, T; Tsuji, N	1
Rui, Q; Wang, XY; Xu, LL; Zhang, LF; Zhang, P	1
Longhi, R; Marturano, J; Protti, MP; Russo, V	1
Andreola, ML; Baranova, SV; Buneva, VN; Calmels, C; Kharitonova, MA; Nevinsky, GA; Parissi, V; Sizyakina, LP	1
Chakraborti, S; Chakraborti, T; Das, S; Mandai, M	1
Akiyama, Y; Matsubara, T; Matsuda, T; Nadano, D; Okajima, T; Oshima, K	1

Other Studies

72 other study(ies) available for leupeptin and pepstatin

Article	Year
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10 Topics: Animals; Antimalarials; Chalcones; Cysteine Endopeptidases; Globins; Heme; Hemeproteins; Hydrolysis; Malaria; Mice; Phenylurea Compounds; Plasmodium berghei; Plasmodium falciparum; Polymers; Protease Inhibitors; Structure-Activity Relationship	2005
Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials. European journal of medicinal chemistry, 2007, Volume: 42, Issue:6 Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Malaria; Male; Mice; Molecular Conformation; Plasmodium berghei; Plasmodium falciparum; Sulfonylurea Compounds	2007
Synthesis, antimalarial activity, structure-activity relationship analysis of thieno-[3,2-b]benzothiazine S,S-dioxide analogs. Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7 Topics: Animals; Antimalarials; Benzene; Crystallography, X-Ray; Globins; Hemeproteins; Mice; Models, Molecular; Molecular Structure; Oxides; Plasmodium berghei; Static Electricity; Structure-Activity Relationship; Thiazines	2008
Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7 Topics: Animals; Antimalarials; Biological Transport, Active; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Drug Resistance; Erythrocytes; Genes, Protozoan; Humans; In Vitro Techniques; Ion Channels; Leupeptins; Malaria, Falciparum; Plasmodium falciparum; Protozoan Proteins	2008
Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives. European journal of medicinal chemistry, 2009, Volume: 44, Issue:3 Topics: Animals; Antimalarials; Magnetic Resonance Spectroscopy; Models, Molecular; Plasmodium berghei; Spectrophotometry, Infrared; Thiazines	2009
Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Animals; Antimalarials; Chalcone; Hemeproteins; Hemoglobins; Humans; Hydrolysis; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Sulfones	2009
Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents. Bioorganic & medicinal chemistry, 2011, Mar-15, Volume: 19, Issue:6 Topics: Animals; Antimalarials; Antitubercular Agents; Benzimidazoles; Cell Line, Tumor; Drug Resistance, Multiple; Hemin; Hemoglobins; Humans; Hydrazines; Hydrolysis; Mice; Plasmodium	2011
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Role of cathepsin D in antigen presentation of ovalbumin. Journal of immunology (Baltimore, Md. : 1950), 1992, Nov-01, Volume: 149, Issue:9 Topics: Animals; Antigen-Presenting Cells; Cathepsin B; Cathepsin D; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Histocompatibility Antigens Class II; In Vitro Techniques; Interleukin-2; Leupeptins; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Ovalbumin; Pepstatins; T-Lymphocytes	1992
Endocytosis and lysosomal delivery of tissue plasminogen activator-inhibitor 1 complexes in Hep G2 cells. Blood, 1992, Dec-01, Volume: 80, Issue:11 Topics: Ammonium Chloride; beta-N-Acetylhexosaminidases; Carcinoma, Hepatocellular; Chloroquine; Endocytosis; Humans; Kinetics; Leupeptins; Liver Neoplasms; Lysosomes; Pepstatins; Plasminogen Activator Inhibitor 1; Primaquine; Recombinant Proteins; Subcellular Fractions; Tissue Plasminogen Activator; Tumor Cells, Cultured	1992
Lymphoproliferative activity of Pseudomonas exotoxin A is dependent on intracellular processing and is associated with the carboxyl-terminal portion. Infection and immunity, 1992, Volume: 60, Issue:4 Topics: ADP Ribose Transferases; Animals; Antigen-Presenting Cells; Bacterial Toxins; Cathepsin D; Endopeptidases; Exotoxins; In Vitro Techniques; Leupeptins; Lymphocyte Activation; Mice; Mice, Inbred Strains; Pepstatins; Peptide Mapping; Protein Processing, Post-Translational; Pseudomonas aeruginosa Exotoxin A; T-Lymphocytes; Thymus Gland; Virulence Factors	1992
Role of hepatic lysosomes in the degradation of metallothionein. Toxicology and applied pharmacology, 1992, Volume: 115, Issue:1 Topics: Animals; Cathepsins; Electrophoresis, Polyacrylamide Gel; Leucine; Leupeptins; Liver; Lysosomes; Male; Metallothionein; Pepstatins; Rats; Rats, Inbred Strains	1992
Different roles for thiol and aspartyl proteases in antigen presentation of ovalbumin. Journal of immunology (Baltimore, Md. : 1950), 1990, Jul-15, Volume: 145, Issue:2 Topics: Animals; Antigen-Presenting Cells; Aspartic Acid Endopeptidases; B-Lymphocytes; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Epitopes; H-2 Antigens; In Vitro Techniques; Leupeptins; Macrophages; Mice; Ovalbumin; Pepstatins; Peptide Fragments; T-Lymphocytes, Helper-Inducer	1990
The selective role of cathepsins B and D in the lysosomal degradation of endogenous and exogenous proteins. FEBS letters, 1991, Aug-05, Volume: 287, Issue:1-2 Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Cathepsin B; Cathepsin D; Dipeptides; Fetuins; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Leupeptins; Liver; Lysosomes; Male; Pepstatins; Proteins; Rats; Rats, Inbred Strains; Thiocyanates	1991
The ability and inability of ATP to stop aluminum from reducing the sodium efflux in unpoisoned barnacle muscle fibers. Biochimica et biophysica acta, 1992, Jan-10, Volume: 1103, Issue:1 Topics: Adenosine Triphosphate; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Biological Transport; Chlorides; Drug Antagonism; Leupeptins; Magnesium Chloride; Myofibrils; Pepstatins; Sodium; Thoracica	1992
Acid proteinases of the fore-gut in metamorphosing tadpoles of Rana catesbeiana. Comparative biochemistry and physiology. B, Comparative biochemistry, 1991, Volume: 99, Issue:3 Topics: Animals; Chromatography, Agarose; Digestive System; Endopeptidases; Hydrogen-Ion Concentration; Larva; Leupeptins; Molecular Weight; Pepstatins; Rana catesbeiana	1991
Effects of synthetic peptides and protease inhibitors on the interaction of a human ovarian cancer cell line (NIH:OVCAR-3) with a reconstituted basement membrane (Matrigel). Invasion & metastasis, 1991, Volume: 11, Issue:2 Topics: Amides; Amino Acid Sequence; Aminocaproates; Antineoplastic Agents; Benzamidines; Biocompatible Materials; Cell Adhesion; Cell Line; Chemotaxis; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Female; Glycoproteins; Humans; In Vitro Techniques; Laminin; Leupeptins; Metalloendopeptidases; Molecular Sequence Data; Neoplasm Invasiveness; Oligopeptides; Ovarian Neoplasms; Pepstatins; Polyamines; Protease Inhibitors; Proteoglycans; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Tyrosine	1991
Effect of calpain inhibitors on the invasion of human erythrocytes by the parasite Plasmodium falciparum. Biochimica et biophysica acta, 1991, Apr-15, Volume: 1096, Issue:3 Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Erythrocytes; Humans; Leucine; Leupeptins; Oligopeptides; Pepstatins; Plasmodium falciparum	1991
Cooperation of lysosomes and inner mitochondrial membrane in the degradation of carbamoyl phosphate synthetase and other proteins. Biochimica et biophysica acta, 1990, Jun-20, Volume: 1034, Issue:3 Topics: Adenosine Triphosphate; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Enzyme Activation; Glutamates; Hydrogen-Ion Concentration; Intracellular Membranes; Leupeptins; Lysosomes; Mitochondria, Liver; Oligopeptides; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Rats; Substrate Specificity	1990
Protein breakdown in submandibular glands rendered hypertrophic by amputation of lower incisor teeth in rats. The Journal of Nihon University School of Dentistry, 1990, Volume: 32, Issue:3 Topics: Aminocaproic Acid; Animals; Antipain; Hypertrophy; Incisor; Leupeptins; Male; Mandible; Pepstatins; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Rats; Rats, Inbred Strains; Salivary Proteins and Peptides; Submandibular Gland	1990
Effect of protease inhibitors on skeletal muscle lysosomal enzyme activity and resting membrane potential. Experimental neurology, 1986, Volume: 94, Issue:3 Topics: Acetylglucosaminidase; Animals; Aprotinin; Chloroquine; Leupeptins; Lysosomes; Male; Membrane Potentials; Muscle Denervation; Muscles; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Rats; Rats, Inbred Strains	1986
Action of endogenous proteases on the distribution of tyrosinase isozymes in Harding-Passey mouse melanoma. Cell biochemistry and function, 1989, Volume: 7, Issue:1 Topics: Animals; Catechol Oxidase; Cathepsin D; Cytosol; Hydrolysis; Isoenzymes; Leupeptins; Melanocytes; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Pepstatins; Peptide Hydrolases; Phenylmethylsulfonyl Fluoride; Solubility	1989
Differences in induction of lysosomal protease activity by protease inhibitors in B16 melanoma cell lines. The International journal of biochemistry, 1989, Volume: 21, Issue:2 Topics: Acid Phosphatase; Animals; Cathepsin B; Enzyme Induction; Leucine; Leupeptins; Melanoma, Experimental; Mice; Oligopeptides; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Subcellular Fractions; Tumor Cells, Cultured	1989
Inhibition of plant cell proteolytic activities that degrade tubulin. Cell biology international reports, 1985, Volume: 9, Issue:9 Topics: Alkaloids; Electrophoresis, Polyacrylamide Gel; Immunosorbent Techniques; Leupeptins; Molecular Weight; Paclitaxel; Pepstatins; Plants; Protease Inhibitors; Tubulin	1985
Four Ca2+-dependent proteinase activities isolated from crustacean muscle differ in size, net charge, and sensitivity to Ca2+ and inhibitors. The Journal of biological chemistry, 1986, Jul-25, Volume: 261, Issue:21 Topics: Animals; Calcium; Calcium Channel Blockers; Calpain; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Iodoacetamide; Leupeptins; Molecular Weight; Muscles; Nephropidae; Pepstatins; Phenylmethylsulfonyl Fluoride	1986
Leukocyte protease activities in myotonic dystrophy: studies on effects of protease inhibitors. European neurology, 1987, Volume: 26, Issue:2 Topics: Aspartic Acid Endopeptidases; Endopeptidases; Granulocytes; Humans; Leukocytes; Leupeptins; Mercuric Chloride; Monocytes; Myotonic Dystrophy; Neprilysin; Oligopeptides; Pepstatins; Protease Inhibitors	1987
Acidic lens-protein-degrading activity in aqueous humour. Experimental eye research, 1986, Volume: 43, Issue:2 Topics: Animals; Aqueous Humor; Cataract; Cattle; Crystallins; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leupeptins; Pepstatins; Protease Inhibitors	1986
[Inhibition of extracellular yeast proteinases by pepstatin A and leupeptin in the plate test]. Mykosen, 1985, Volume: 28, Issue:3 Topics: Agar; Blastomyces; Candida; Depression, Chemical; Endopeptidases; Geotrichum; Leupeptins; Mitosporic Fungi; Oligopeptides; Pepstatins; Species Specificity	1985
Lysosomal digestion of thyroglobulin: role of cathepsin D and thiol proteases. Endocrinology, 1985, Volume: 117, Issue:4 Topics: Animals; Cathepsin D; Cysteine Endopeptidases; Endopeptidases; Hydrogen-Ion Concentration; Iodine; Leupeptins; Lysosomes; Mercaptoethanol; Monoiodotyrosine; Pepstatins; Pronase; Protease Inhibitors; Swine; Thyroglobulin	1985
Isolation of two forms of the high-molecular-mass serine protease, ingensin, from porcine skeletal muscle. FEBS letters, 1985, Sep-09, Volume: 189, Issue:1 Topics: Animals; Antipain; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, High Pressure Liquid; Coumarins; Cysteine Endopeptidases; Endopeptidases; Isoenzymes; Leucine; Leupeptins; Multienzyme Complexes; Muscles; Oligopeptides; Pepstatins; Proteasome Endopeptidase Complex; Sodium Dodecyl Sulfate; Swine	1985
Acidic lens protein degrading activity in bovine ciliary body. Experimental eye research, 1985, Volume: 40, Issue:3 Topics: Animals; Cattle; Chromatography; Ciliary Body; Crystallins; Cysteine; Hydrogen-Ion Concentration; Leupeptins; Pepstatins; Protease Inhibitors	1985
Molecular forms of GM2-activator protein. A study on its biosynthesis in human skin fibroblasts. Biological chemistry Hoppe-Seyler, 1985, Volume: 366, Issue:9 Topics: Cells, Cultured; Endocytosis; Enzyme-Linked Immunosorbent Assay; Fibroblasts; G(M2) Activator Protein; G(M2) Ganglioside; Gangliosides; Gangliosidoses; Humans; Kinetics; Leucine; Leupeptins; Lysosomes; Pepstatins; Phenylmethylsulfonyl Fluoride; Protein Biosynthesis; Skin; Tritium	1985
Comparative effects of cathepsin inhibitors on rat embryonic development in vitro. Evidence that cathepsin D is unimportant in the proteolytic function of yolk sac. Journal of embryology and experimental morphology, 1985, Volume: 86 Topics: Animals; Cathepsin D; Cathepsins; Cells, Cultured; Embryonic and Fetal Development; Hemoglobins; Hydrogen-Ion Concentration; Leupeptins; Pepstatins; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Time Factors; Yolk Sac	1985
Lysosomal function in the degradation of defective collagen in cultured lung fibroblasts. Biochemistry, 1984, May-08, Volume: 23, Issue:10 Topics: Cells, Cultured; Collagen; Endopeptidases; Female; Fibroblasts; Humans; Leupeptins; Lung; Lysosomes; Pepstatins; Pregnancy; Procollagen; Tosyllysine Chloromethyl Ketone	1984
An abnormality in intracellular protein degradation in fibroblasts from patients with I-cell disease. Clinica chimica acta; international journal of clinical chemistry, 1984, Jul-31, Volume: 140, Issue:3 Topics: Ammonium Chloride; Cytosol; Fibroblasts; Half-Life; Humans; Leupeptins; Lysosomes; Mucolipidoses; Pepstatins; Proteins	1984
The proteinase inhibitors leupeptin, pepstatin A, and TLCK cause reduced collagen production in freshly isolated embryonic chick fibroblasts in suspension culture. Archives of biochemistry and biophysics, 1984, Volume: 233, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Animals; Chick Embryo; Collagen; Fibroblasts; In Vitro Techniques; Leupeptins; Oligopeptides; Pepstatins; Tendons; Tosyllysine Chloromethyl Ketone	1984
Role of thiols, pH and cathepsin D in the lysosomal catabolism of serum albumin. The Biochemical journal, 1984, Mar-15, Volume: 218, Issue:3 Topics: Animals; Cathepsin D; Cathepsins; Cysteine; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Iodoacetamide; Kidney; Leupeptins; Liver; Lysosomes; Mice; Pepstatins; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Sulfhydryl Compounds	1984
Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores. The Journal of biological chemistry, 1984, Aug-10, Volume: 259, Issue:15 Topics: Amines; Ammonium Chloride; Animals; Antigens, Surface; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Humans; Ionophores; Isoantibodies; Kinetics; Leukemia, Experimental; Leupeptins; Mice; Monensin; Nigericin; Pepstatins; Protein Biosynthesis; Ricin	1984
The regulation of proteolysis in normal fibroblasts as they approach confluence. Evidence for the participation of the lysosomal system. The Biochemical journal, 1982, Dec-15, Volume: 208, Issue:3 Topics: Ammonium Chloride; Animals; Cells, Cultured; Diazomethane; Fibroblasts; Humans; Leupeptins; Lysosomes; Mice; Pepstatins; Proteins	1982
In vitro stability of endogenous parathyroid hormone-related protein in blood and plasma. Annals of clinical biochemistry, 1994, Volume: 31 ( Pt 1) Topics: Anticoagulants; Aprotinin; Blood Specimen Collection; Edetic Acid; Heparin; Humans; Hypercalcemia; Immunoradiometric Assay; In Vitro Techniques; Infant; Leupeptins; Neoplasms; Parathyroid Hormone-Related Protein; Pepstatins; Peptide Fragments; Peptides; Protease Inhibitors; Temperature	1994
The role of proteases in stratum corneum: involvement in stratum corneum desquamation. Archives of dermatological research, 1994, Volume: 286, Issue:5 Topics: Antipain; Aprotinin; Detergents; Endopeptidases; Epidermis; Ethylmaleimide; Humans; Leucine; Leupeptins; Oligopeptides; Pepstatins; Protease Inhibitors; Sunburn	1994
Protection by lysosomal hydrolase inhibitors against cytotoxicity of 2-chloroethylethyl sulfide. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:7 Topics: Alkylation; Animals; Cell Survival; Cells, Cultured; Drug Interactions; Gentamicins; Kanamycin; Leupeptins; Lysosomes; Mice; Mice, Inbred ICR; Mustard Gas; Oligopeptides; Pepstatins; Phospholipases; Protease Inhibitors; Spleen; Streptomycin; Structure-Activity Relationship; T-Lymphocytes	1995
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. The EMBO journal, 1995, Aug-01, Volume: 14, Issue:15 Topics: Animals; Atrophy; B-Lymphocytes; Cathepsin D; Chimera; Fibroblasts; Gene Targeting; Ileum; Intestinal Mucosa; Leupeptins; Lysosomes; Male; Mice; Mice, Inbred C57BL; Pepstatins; RNA, Messenger; Specific Pathogen-Free Organisms; Spleen; T-Lymphocytes; Thymus Gland	1995
Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites. Experimental parasitology, 1995, Volume: 80, Issue:2 Topics: Animals; Antimalarials; Chymotrypsin; Coumarins; Cysteine Proteinase Inhibitors; Dipeptides; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Fluorescent Dyes; Globins; Humans; Hydrolysis; Leucine; Leupeptins; Oligopeptides; Pepstatins; Plasmodium falciparum; Vacuoles	1995
Effects of exogenous protease effectors on beef tenderness development and myofibrillar degradation and solubility. Journal of animal science, 1994, Volume: 72, Issue:5 Topics: Animals; Calcimycin; Calcium; Calpain; Cathepsins; Cattle; Cysteine Proteinase Inhibitors; Diazomethane; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Glycoproteins; Leucine; Leupeptins; Male; Meat; Muscle Proteins; Muscles; Octoxynol; Pepstatins; Phenylmethylsulfonyl Fluoride; Postmortem Changes; Solubility	1994
Kinetic studies on phagocytosis and lysosomal digestion of rod outer segments by human retinal pigment epithelial cells in vitro. Experimental cell research, 1994, Volume: 210, Issue:2 Topics: alpha-Mannosidase; Animals; Aspartic Acid Endopeptidases; Cattle; Cell Membrane; Cells, Cultured; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leupeptins; Lysosomes; Mannosidases; Microscopy, Electron; Microscopy, Electron, Scanning; Pepstatins; Phagocytosis; Pigment Epithelium of Eye; Rod Cell Outer Segment; Swainsonine; Zinc	1994
Generation of VV-hemorphin-7 from globin by peritoneal macrophages. FEBS letters, 1996, Mar-11, Volume: 382, Issue:1-2 Topics: Amino Acid Sequence; Amino Acids; Animals; Cathepsin D; Cattle; Cells, Cultured; Female; Globins; Hemoglobins; Hydrolysis; Leupeptins; Lysosomes; Macrophages, Peritoneal; Mice; Molecular Sequence Data; Pepstatins; Peptide Fragments; Protease Inhibitors; Specific Pathogen-Free Organisms	1996
Proteinases in renal cell death. Journal of toxicology and environmental health, 1996, Volume: 48, Issue:4 Topics: Animals; Anti-Bacterial Agents; Antimycin A; Antipain; Carboxypeptidases; Cathepsin A; Cathepsin B; Cell Death; Coumarins; Cysteine; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endopeptidases; Hydrocarbons, Fluorinated; Hydroquinones; Isocoumarins; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Leucine; Leupeptins; Lysosomes; Membrane Potentials; Pepstatins; Peroxides; Rabbits; Reactive Oxygen Species; Serine Proteinase Inhibitors; tert-Butylhydroperoxide; Tosyllysine Chloromethyl Ketone	1996
Granulocytic protein p25 is a DNA-binding subunit of protein M(r) = 50,000: subcellular localization, cell and species specificity. The international journal of biochemistry & cell biology, 1996, Volume: 28, Issue:4 Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antigen-Antibody Reactions; Chromobox Protein Homolog 5; DNA-Binding Proteins; Granulocytes; Humans; In Vitro Techniques; Leupeptins; Molecular Sequence Data; Pepstatins; Protease Inhibitors; Reference Values; Species Specificity; Subcellular Fractions	1996
Effects of lysosomal protease inhibitors on the degradation of acetylated low density lipoprotein in cultured rat peritoneal macrophages. Journal of atherosclerosis and thrombosis, 1994, Volume: 1, Issue:1 Topics: Acetylation; Animals; Cells, Cultured; Cholesterol; Humans; Iodine Radioisotopes; Leupeptins; Lipoproteins, LDL; Lysosomes; Macrophages, Peritoneal; Oleic Acid; Pepstatins; Protease Inhibitors; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tritium	1994
Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1997, Volume: 11, Issue:8 Topics: Antibiotics, Antineoplastic; Antipain; Apoptosis; Ceramides; Coumarins; Daunorubicin; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; HL-60 Cells; Humans; Hydrolysis; Isocoumarins; Leupeptins; NF-kappa B; Pepstatins; Protease Inhibitors; Serine Proteinase Inhibitors; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured	1997
Carboxy-terminal truncation of long-tailed amyloid beta-peptide is inhibited by serine protease inhibitor and peptide aldehyde. FEBS letters, 1998, Mar-13, Volume: 424, Issue:3 Topics: Amino Acids; Amyloid beta-Peptides; Animals; Antipain; Brain; Carboxypeptidases; Chloromercuribenzoates; Edetic Acid; Leupeptins; p-Chloromercuribenzoic Acid; Pepstatins; Peptide Fragments; Phenylmethylsulfonyl Fluoride; Rats; Serine Proteinase Inhibitors	1998
Submandibular salivary proteases: lack of a role in anti-HIV activity. Journal of dental research, 1998, Volume: 77, Issue:7 Topics: Anti-HIV Agents; Aprotinin; Benzamidines; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cysteine Proteinase Inhibitors; Edetic Acid; Egtazic Acid; Endopeptidases; Ethylmaleimide; HIV-1; Humans; Isoflurophate; Leupeptins; Metalloendopeptidases; Norleucine; Parotid Gland; Pepstatins; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Saliva; Serine Proteinase Inhibitors; Submandibular Gland; Trypsin Inhibitor, Bowman-Birk Soybean	1998
Degradation of serum albumin by rat liver and kidney lysosomes. Journal of nutritional science and vitaminology, 1998, Volume: 44, Issue:5 Topics: Animals; Cathepsins; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Electrophoresis, Polyacrylamide Gel; Kidney; Leupeptins; Liver; Lysosomes; Male; Pepstatins; Rats; Rats, Wistar; Serum Albumin	1998
Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB10401-positive individuals. Journal of immunology (Baltimore, Md. : 1950), 1999, Aug-01, Volume: 163, Issue:3* Topics: Antigen Presentation; Antigen-Presenting Cells; B-Lymphocytes; Cell Line, Transformed; Cell Lineage; Epitopes, T-Lymphocyte; Glutamate Decarboxylase; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Leupeptins; Lymphocyte Activation; Pepstatins; Protease Inhibitors; Transfection	1999
Identification of soluble forms of lectin-like oxidized LDL receptor-1. Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:3 Topics: Amino Acid Sequence; Animals; Aorta; Aprotinin; Arteriosclerosis; Biotinylation; Cattle; Cell Membrane; CHO Cells; Cricetinae; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Endopeptidases; Endothelium, Vascular; Glycoproteins; Lectins; Leupeptins; Lipoproteins, LDL; Membrane Proteins; Molecular Sequence Data; Pepstatins; Protease Inhibitors; Protein Structure, Tertiary; Receptors, LDL; Receptors, Oxidized LDL; Serine Proteinase Inhibitors; Solubility; Tosyl Compounds; Tosyllysine Chloromethyl Ketone; Tumor Necrosis Factor-alpha	2000
Suppression of endothelin-converting enzyme-1 during buccal mucosal ulcer healing: effect of chronic alcohol ingestion. Biochemical and biophysical research communications, 2000, May-10, Volume: 271, Issue:2 Topics: Animals; Apoptosis; Aspartic Acid Endopeptidases; Edetic Acid; Endothelin-Converting Enzymes; Epithelial Cells; Ethanol; Leupeptins; Metalloendopeptidases; Mouth Mucosa; Oral Ulcer; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Time Factors; Tosyl Compounds; Tumor Necrosis Factor-alpha; Up-Regulation; Wound Healing	2000
Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation. Journal of immunology (Baltimore, Md. : 1950), 2000, May-15, Volume: 164, Issue:10 Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line, Transformed; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epitopes, T-Lymphocyte; Hepatitis B e Antigens; Histocompatibility Antigens Class I; HIV Envelope Protein gp160; HIV-1; Humans; Hydrolysis; Leupeptins; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Pepstatins; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes, Cytotoxic	2000
Changes in the Ca2+-activation characteristics of demembranated rat single muscle fibres after prolonged incubation at room temperature in the presence and absence of DTT and protease inhibitors. Pflugers Archiv : European journal of physiology, 2000, Volume: 440, Issue:5 Topics: Adenosine Triphosphatases; Animals; Calcium; Dithiothreitol; Histological Techniques; Leupeptins; Male; Muscle Contraction; Muscle Fibers, Skeletal; Myofibrils; Osmolar Concentration; Pepstatins; Protease Inhibitors; Rats; Rats, Long-Evans; Temperature; Time Factors	2000
Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+). Free radical biology & medicine, 2001, Jan-01, Volume: 30, Issue:1 Topics: Acridine Orange; Adenine; Animals; Aurothioglucose; Cadmium; Cell Death; Chloroquine; Copper; Endopeptidases; Enzyme Activation; Gentamicins; Leupeptins; Lipid Peroxidation; Liver; Lysosomes; Male; Methylamines; Monensin; Oxidation-Reduction; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2001
Association between bcl-x(L) and 5-lipoxygenase activating protein (FLAP) levels in IL-3-dependent FL5.12 cells. Toxicology, 2001, Mar-07, Volume: 160, Issue:1-3 Topics: 5-Lipoxygenase-Activating Proteins; bcl-X Protein; Blotting, Northern; Blotting, Western; Carrier Proteins; Caspase Inhibitors; Cells, Cultured; Cloning, Molecular; Enzyme Inhibitors; Hematopoietic Stem Cells; Interleukin-3; Leupeptins; Membrane Proteins; Pepstatins; Phenylmethylsulfonyl Fluoride; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Transfection	2001
Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome. Journal of immunology (Baltimore, Md. : 1950), 2001, May-01, Volume: 166, Issue:9 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Aprotinin; Autoantigens; Carrier Proteins; Caspases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Herpesvirus 4, Human; Humans; Hydrolysis; Leucine; Leupeptins; Microfilament Proteins; Molecular Weight; Organ Specificity; Pepstatins; Sjogren's Syndrome; Trans-Activators; Tumor Cells, Cultured; Viral Proteins; Virus Activation	2001
Human muscle protein degradation in vitro by eosinophil cationic protein (ECP). Muscle & nerve, 2001, Volume: 24, Issue:12 Topics: Actinin; Blood Proteins; Cysteine Proteinase Inhibitors; Cytoskeleton; Dose-Response Relationship, Drug; Dystrophin; Eosinophil Granule Proteins; Eosinophils; Fibrinolytic Agents; Heparin; Humans; In Vitro Techniques; Inflammation Mediators; Leupeptins; Muscle Proteins; Myofibrils; Myosin Heavy Chains; Myositis; Pepstatins; Protease Inhibitors; Ribonucleases; Sarcoplasmic Reticulum; Spectrin; Zinc	2001
Complexity of agonist- and cyclic AMP-mediated downregulation of the human beta 1-adrenergic receptor: role of internalization, degradation, and mRNA destabilization. Biochemistry, 2002, Jun-25, Volume: 41, Issue:25 Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Cricetinae; Cyclic AMP; Down-Regulation; Humans; Isoproterenol; Leupeptins; Molecular Sequence Data; Pepstatins; Protease Inhibitors; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; RNA Stability; RNA, Messenger; Thionucleotides	2002
Natural killer-like cells in the sheep: functional characterization and regulation by pregnancy-associated proteins. Experimental biology and medicine (Maywood, N.J.), 2002, Volume: 227, Issue:9 Topics: Animals; Antibodies, Monoclonal; Dogs; Endometrium; Epithelial Cells; Female; Humans; Interferon Type I; Killer Cells, Natural; Leupeptins; Lymphocytes; Membrane Glycoproteins; Membrane Proteins; Pepstatins; Perforin; Pore Forming Cytotoxic Proteins; Pregnancy; Pregnancy Proteins; Protease Inhibitors; Serpins; Sheep; Tumor Cells, Cultured	2002
Involvement of proteases in the action of IFN-gamma on WISH cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2002, Volume: 22, Issue:8 Topics: Amnion; Cell Division; Cell Line; Cell Membrane; DNA Replication; Humans; Interferon-gamma; Leupeptins; Lysine; Pepstatins; Phenylalanine; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors; Subcellular Fractions; Thiorphan; Tosyllysine Chloromethyl Ketone; Trypsin Inhibitor, Bowman-Birk Soybean	2002
Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis. The Journal of veterinary medical science, 2004, Volume: 66, Issue:10 Topics: Animals; Antipain; Chromogenic Compounds; Escherichia coli; Fluorescent Dyes; Hydrogen-Ion Concentration; Ixodidae; Leucine; Leupeptins; Pepstatins; Phenylmethylsulfonyl Fluoride; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Temperature	2004
A novel 51-kDa fragment of the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase formed in the stroma of chloroplasts in dark-induced senescing wheat leaves. Physiologia plantarum, 2007, Volume: 131, Issue:1 Topics: Chloroplasts; Darkness; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Leupeptins; Pepstatins; Phenanthrolines; Plant Leaves; Protein Subunits; Protons; Ribulose-Bisphosphate Carboxylase; Sulfones; Temperature; Triticum	2007
Endosomal proteases influence the repertoire of MAGE-A3 epitopes recognized in vivo by CD4+ T cells. Cancer research, 2008, Mar-01, Volume: 68, Issue:5 Topics: Antigen Presentation; Antigens, Neoplasm; CD4-Positive T-Lymphocytes; Dendritic Cells; Endosomes; Epitopes; Humans; Immunophenotyping; Leukocytes, Mononuclear; Leupeptins; Models, Biological; Neoplasm Proteins; Pepstatins; Peptide Hydrolases; Peptides; Th2 Cells	2008
HIV-1 integrase-hydrolyzing antibodies from sera of HIV-infected patients. Biochimie, 2009, Volume: 91, Issue:9 Topics: Adolescent; Adult; Antibodies, Catalytic; Chromatography, Affinity; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; HIV Infections; HIV Integrase; Humans; Hydrolysis; Leupeptins; Male; Pepstatins; Protease Inhibitors; Sulfones; Young Adult	2009
Matrix metalloprotease 2-mediated activation of Ca(2+)-ATPase by superoxide radical (O2-) in plasma membrane of bovine pulmonary vascular smooth muscle. Indian journal of biochemistry & biophysics, 2002, Volume: 39, Issue:6* Topics: Animals; Antipain; Calcium-Transporting ATPases; Cattle; Cell Membrane; Ethylmaleimide; Free Radicals; Hypoxanthine; Leupeptins; Lung; Matrix Metalloproteinase 2; Muscle, Smooth; Muscle, Smooth, Vascular; Oligopeptides; Oxygen; Pepstatins; Phenylmethylsulfonyl Fluoride; Superoxides; Tissue Inhibitor of Metalloproteinase-2; Trypsin Inhibitor, Bowman-Birk Soybean	2002
Dephosphorylation reduces passage of ovalbumin antigen through intestinal epithelial Caco-2 cell monolayers. Journal of biochemistry, 2013, Volume: 153, Issue:4 Topics: Alkaline Phosphatase; Animals; Antigens; Caco-2 Cells; Cathepsins; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Female; Humans; Intestinal Mucosa; Leupeptins; Mice; Mice, Inbred Strains; Ovalbumin; Pepstatins; Phosphorylation; Protease Inhibitors	2013