Page last updated: 2024-08-25

leupeptin and leupeptins

leupeptin has been researched along with leupeptins in 893 studies

Research

Studies (893)

TimeframeStudies, this research(%)All Research%
pre-1990325 (36.39)18.7374
1990's332 (37.18)18.2507
2000's166 (18.59)29.6817
2010's65 (7.28)24.3611
2020's5 (0.56)2.80

Authors

AuthorsStudies
Martonosi, A; Varga, S1
Isobe, N; Kaneko, H; Nakatsuka, I; Saito, K; Yamada, H; Yoshitake, A1
Ashall, F; Djamgoz, MB; Floyd, DN1
Ramanujam, KS; Seetharam, B; Seetharam, S2
Eto, I; Grubbs, CJ1
Denison, MR; Giangreco, B; Hughes, SA; Leibowitz, JL; Olson, AL; Perlman, S; Weiss, SR; Zoltick, PW1
Clementi, F; Passafaro, M; Sher, E1
Diment, S; Rodriguez, GM1
Morton, PA; Owensby, DA; Schwartz, AL; Underhill, DM1
Ivy, GO2
Kilbourne, EJ; Lewis, EJ; McMahon, A; Nankova, BB; Osaka, H; Sabban, DB; Sabban, EL1
Hara, M; Inagaki, C; Omori, K; Otani, H; Zeng, XT1
Carlton, E; Morgan, CH; Pandian, MR; Segre, GV1
Bang, YJ; Danielpour, D; Kim, KY; Kim, SJ; Myers, CE; O'Reilly, MA; Trepel, JB1
Cappuccinelli, P; Fíori, PL; Manca, C; Mattana, A; Rappelli, P1
Berndt, MC; Ribeiro, A; Swann, JC1
Berg, T; Roseng, L; Tolleshaug, H1
Bevan, D; Harrison, P; Inbal, A; Lawrie, A; LeRoy, F; Rowley, M; Savidge, G; Wilbourn, B1
Chevalier, D; Moore, RB; Plishker, GA; Seinsoth, L1
Badalamente, MA; Hurst, LC; Stracher, A3
Marinelli, RA; Peñalva, GL1
Banerjee, D; Grieninger, G; Mukhopadhyay, G; Oddoux, C; Overton, O; Redman, C; Roy, S; Yu, S1
Lopata, A; Tawia, SA1
Fukushima, T; Sasaki, H; Sekizawa, K; Takishima, T; Yamauchi, K; Yamaya, M; Zayasu, K1
Azuma, M; David, LL; Kadoya, K; Lampi, KJ; Shearer, TR1
Bailey, GS; el-Thaher, TS; Moore, GR; Osborne, M; Wilson, MT1
Niwano, H; Shibata, A; Takahashi, H; Tatewaki, W; Wada, K1
Kumar, A; Shafiq, S; Stracher, A; Wadgaonkar, R1
Dobberstein, B; Griffiths, G; Zachgo, S1
Mizuno, K; Nakamura, T; Takehara, T1
DeMartino, GN; Dick, LR; Moomaw, CR; Pramanik, BC; Slaughter, CA1
Heikoop, JC; Just, WW; Meijer, AJ; Strijland, A; Tager, JM; van den Berg, M; Weijers, PJ1
Tai, H; Yamaguchi, M1
Benacerraf, B; Colarusso, LJ; Falo, LD; Rock, KL1
Bianchi, CP; Booz, GW1
Aoba, A; Asakura, M; Hasegawa, K; Ivy, GO; Kanai, S; Kitani, K; Ohta, M; Shibata, M1
Bisiau, H; Degand, P; Demeyer, D; Han, KK; Huet, G; Richet, C; Soudan, B; Tetaert, D1
Legaard, PK; LeGrand, RD; Misfeldt, ML1
Aoyagi, T; Hayashi, H; Hori, M; Moriya, Y; Nagai, M; Otani, T; Sakata, N; Tsuchiya, KS1
Kenney, DM; Remold-O'Donnell, E; Van Brocklyn, J1
Bacher, A; Ben-Shaul, Y; Griebl, K; Mackamul, S; Mitreiter, R; Mückter, H1
Haspel, HC; Honkanen, RA; Klingman, DE; Ortiz, PA1
Haass, C; Hung, AY; Koo, EH; Mellon, A; Selkoe, DJ1
Choudhuri, S; Klaassen, CD; McKim, JM1
Chowdhury, MH; Dempster, DW; Hamada, C1
Knops, J; Lieberburg, I; Sinha, S1
Boschwitz, H; Gofshtein-Gandman, L; Halvorson, HO; Keynan, A; Milner, Y1
Danielsen, EM; Hansen, GH; Wetterberg, LL1
Aoyagi, T; Harada, S; Hirokawa, K; Kojima, F; Nagai, M; Takahashi, H; Takeuchi, T; Tsumita, T; Wada, T1
Homma, S; Oppenheim, RW; Prevette, D; Tytell, M1
Diment, S1
Grun, JL; Liu, DC; Maurer, PH1
Anonick, PK; Gonias, SL1
Jani, JP; Lazo, JS; Mistry, JS; Morris, G; Sebti, SM1
Clarke, GA; Garrett, JR; Proctor, GB; Smith, RE1
Katunuma, N; Kominami, E; Muno, D; Ueno, T1
Smith, RS; Snyder, RE1
Chiyotani, A; Isono, K; Kanemura, T; Konno, K; Sakai, N; Takizawa, T; Tamaoki, J; Yamauchi, F1
Bettens, F; Brander, C; Mijic, D; Pichler, WJ; Wyss-Coray, T1
Bittar, EE; Huang, YP1
Ichinose, M; Inoue, H; Katsumata, U; Kimura, K; Miura, M; Takahashi, T; Takishima, T1
Estus, S; Golde, TE; Selkoe, DJ; Younkin, LH; Younkin, SG1
Horiuchi, S; Inokuchi, T; Kobayashi, KI1
Bhattacharyya, J; Sayeed, MM; Thompson, K1
Rivett, AJ; Savory, PJ2
Baron, PL; Meola, G; Moggio, M; Santilli, I; Scarlato, G; Scarpini, E1
Collins, AR; Grubb, A1
Chiyotani, A; Horii, S; Isono, K; Kanemura, T; Kobayashi, K; Sakai, N; Takeuchi, S; Takizawa, T; Tamaoki, J; Yamawaki, I1
Anderson, SK; Geissler, F; Press, O1
Aubery, M; Bauvy, C; Codogno, P; Darmoul, D; Ogier-Denis, E; Sapin, C; Trugnan, G1
Arai, A; Frank, S; Lee, KS; Lynch, G; Vanderklish, P1
Knutson, VP1
Benacerraf, B; Rock, KL; Vidard, L1
Hanawalt, PC; Hebda, PA; Kane, CJ; Mansbridge, JN1
Ortiz, C; Scott, AI; Stolowich, NJ; Tellier, C; Williams, H1
Hayashi, M; Inomata, M; Ito, H; Kawashima, S; Saito, Y1
Fridman, R; Hamilton, TC; Kanemoto, T; Martin, GR1
Adams, GE; Cundall, RB; Hasan, NM1
Ginsburg, H; Krugliak, M1
Gardner, MB; Gershwin, ME; McGraw, TP; Vowels, BR1
Beermann, ML; Nixon, RA; Shea, TB1
Axelsson, KL; Hellem, S; Olofsson, J; Rydell, EL1
Dimlich, RV; Fischer, JE; Hall-Angerås, M; Hasselgren, PO1
DeMartino, GN; Dick, LR; Moomaw, CR; Slaughter, CA1
Edwards, RH; MacLennan, PA; McArdle, A1
Olaya, P; Wasserman, M1
Charest, DL; Howard, SL; Pelech, SL; Salari, H; Samiei, M1
Ivy, GO; Kanai, S; Kitani, K; Ohta, M; Otsubo, K; Sato, Y1
Schlaepfer, WW; Zimmerman, UJ2
Khalfan, HA1
Mercer, JR; Silva, SV1
Armstrong, DL; Denny, JB; Ghuman, A; Polan-Curtain, J; Wayner, MJ1
Horton, AA; Wood, JM1
Augustine, EC; Kensinger, RS1
Mauss, EA; Puszkin, EG; Zucker, MB1
Blum, JS; Cresswell, P; Davis, JE; Marks, MS1
Goldberg, IJ; Klein, MG; Saxena, U1
Feher, JJ; LeBolt, WR1
Arai, A; Kessler, M; Lee, K; Lynch, G1
Grisolía, S; Knecht, E; Vargas, JL1
Angerås, U; Benson, D; Fischer, JE; Hall-Angerås, M; Hasselgren, PO; James, JH1
Hoshi, M; Sawada, H; Yamazaki, K1
Grisolía, S; Hernández-Yago, J; Knecht, E; Vargas, JL1
Hirose, M; Kominami, E; Namihisa, T; Ueno, T; Watanabe, S1
Danno, K; Hirayoshi, K; Hosokawa, M; Imamura, S; Miyachi, Y; Nagata, K; Nishigori, C; Takeda, T; Tanaka, T; Utani, A1
Clem, LW; Jørgensen, T; Miller, NW; Vallejo, AN1
Sano, M; Seto, A; Tsukimura, T; Yamazaki, A1
Gottesman, MM; Salminen, A1
Adachi, Y; Hatanaka, M; Lee, WJ; Maki, M; Murachi, T1
Liuzzi, FJ1
Billington, D; Gilmore, IT; Gore, S; Morris, AI1
Bohley, P; Gordon, PB; Kisen, GO; Kopitz, J; Seglen, PO1
Nafz, MA; Varandani, PT1
Daikuhara, Y; Gohda, E; Hashimoto, S; Miyazaki, H; Nakayama, H; Nakazono, Y; Tsubouchi, H1
Friedman, V; Lonai, P; Puri, J1
Chida, K; Kato, N; Kuroki, T1
Atwood, HL; Boegman, RJ; Scarth, B1
Ino, Y; Iwaki, M; Sato, T; Suzuki, K1
Chad, JE; Eckert, R; Kalman, D1
Conner, RL; Deyo, RA; Panksepp, J1
Birnbaumer, L; Brown, AM; Codina, J; Imoto, Y; Reeves, JP; Yatani, A1
Nishimura, C; Nishimura, T; Suzuki, H; Tanaka, N1
Garg, BD; Mancini, MA; Olson, MJ; Roy, AK1
Chen, JK; Cook, JR1
Findlay, I1
Alkon, DL; Bank, B; Chen, C; Gallant, P; Kubota, M; Naito, S; Rasmussen, H; Smallwood, J1
Castiglione, E; Chatterjee, S; Ghosh, N; Kwiterovich, PO1
Eisenlohr, LC; Gerhard, W; Hackett, CJ1
Dufy, B; Taupignon, AI1
Lasek, RJ; Sahenk, Z1
Berzofsky, JA; Cease, KB; Takahashi, H1
Bazan, JF; Cary, SM; Dougherty, WG; Fletterick, RJ; Parks, TD1
Bowles, VM; Carnegie, PR; Sandeman, RM1
Kihara, HK; Miyata, S; Yoshida, Y1
Berra, A; Monserrat, AJ; Porta, EA; Rubio, MC1
Ivy, GO; Kanai, S; Kitani, K; Kobayashi, M; Ohta, M; Sato, Y; Smith, G1
Ivy, GO; Kanai, S; Kitani, K; Nokubo, M; Ohta, M; Otsubo, K; Sato, Y1
Banker, DE; Gottesman, MM; Herschman, HR; Pastan, I1
Boscá, L; Díaz-Guerra, MJ; Mojena, M1
Bouillot, C; Disdier, M; Dubernard, V; Legrand, C; Nurden, AT; Pidard, D1
Lozano, JA; Martinez, JH; Solano, F1
Buettner, HM; Ivins, JK; Pittman, RN1
Amara, JF; Lederkremer, G; Lodish, HF1
Bennett, V; Davis, J; Davis, L1
Au, KS; Lee, MF; Siu, YL1
Ishida, E; Ito, M; Sato, A; Shigeta, S; Takami, Y; Tanabe, F1
Bradford, H; Colman, RF; Colman, RW; Hu, CJ; Puri, RN; Zhou, FX1
Hirata, Y; Inoue, Y; Marumo, K; Tasaka, Y1
Nishikata, M; Nodasaka, Y; Yoshimura, F1
Dosch, SF; Graziani, LA; Pickart, CM1
Rizzolo, LJ1
Gerrard, JM; MacIntyre, DE; McNicol, A1
Beertsen, W; Everts, V; Hembry, RM; Reynolds, JJ1
Hayashi, M; Inomata, M; Kawashima, S; Nakamura, M; Saito, Y1
Clarke, BL; Weigel, PH1
Alpers, DH; Ramasamy, M; Seetharam, B; Tiruppathi, C1
Fesus, L; Tarcsa, E1
Berlet, HH; Ilzenhöfer, H1
Donlon, JA; Donlon, MA; Helgeson, EA1
Bajusz, S; Makara, GB; Nagy, I; Rappay, G1
Dieffenbach, CW; Friedman, RM; Jacobsen, H; Krause, D; Leisy, SA; Silverman, RH1
Dallinga-Thie, GM; van 't Hooft, FM; van Tol, A1
Moss, AL; Ward, WF1
Baudry, M; Lynch, G; Oliver, MW1
Nanci, A; Smith, CE1
Blum, JS; Cresswell, P; Marks, MS; Roche, PA1
Korbelik, M; Osmak, M; Skrk, J; Suhar, A; Turk, V1
Garcia de Herreros, A1
Debrabant, A; Delplace, P1
Kurita, Y; Nakao, H; Ogawa, H; Takamori, K; Tsuboi, R2
Chen, L; Tai, PC1
Kovács, J; Réz, G1
Inui, K; Nishimoto, J; Okada, S; Yabuuchi, H1
Miyoshi, K; Takauchi, S2
Hara, T; Kato, Y; Umemoto, N1
Conner, RL; Deyo, RA1
Decker, SJ1
Becker, EL; Gomez-Cambronero, J; Molski, TF; Sha'afi, RI1
Guccione, MA; Livne, A; Mustard, JF; Packham, MA1
Aktories, K; Jakobs, KH1
Brass, LF; Shattil, SJ1
Maeda, M; Neda, H; Niitsu, Y; Sone, H; Urushizaki, I; Watanabe, N; Yamauchi, N1
Bevers, EM; Comfurius, P; Verhallen, PF; Zwaal, RF1
McClain, DA; Olefsky, JM1
Higuchi, N; Kajiwara, Y; Kambayashi, J; Mori, T; Sakon, M; Tanaka, T; Tsujinaka, T1
Kaba, H; Keverne, EB1
Baudry, M; Ivy, G; Larson, J; Lee, J; Lynch, G; Seubert, P; Shahi, K1
Baudry, M; Ivy, G; Lynch, G; Seubert, P1
Geratz, JD; Miskuff, RL; Sato, S; Tidwell, RR; Vonderfecht, SL; Wee, SB; Yolken, RH1
Angelastro, MR; Bey, P; Mehdi, S; Wiseman, JS1
Au, KS; Hsu, L; Morrison, M1
Charlwood, PA; Chindemi, PA; Regoeczi, E1
Flint, DJ; Jeffrey, IW; Mayer, RJ; Vernon, RG1
Bureau, TE; Fosket, DE; Morejohn, LC1
Presky, DH; Schonbrunn, A1
Ballou, B; Hakala, TR; Ryser, HJ; Shen, WC1
Cowell, GM; Danielsen, EM2
Ando, Y; Imamura, S; Kannagi, R; Kitahara, A; Murachi, T; Saji, H; Yamagata, Y1
Baudry, M; Hagan, JJ; Jensen, J; Lynch, GS; Morris, RG; Nadel, L1
Beynon, RJ; Chetland, J; Galpin, IJ; Place, GA1
Frankfater, A; Kozlowski, KA; Orawski, AT; Ortiz, R; Pagast, P; Schultz, RM; Varma-Nelson, P1
Carpentier, JL; Hachiya, HL; King, GL1
Dawson, G; Hancock, LW1
Lapetina, EG; Ruggiero, M4
Connolly, JA; Simard, G1
Hozumi, N; Watanabe, M; Yoshikawa, M1
Cunningham, DD; McKinley, DN; VanNostrand, W; Wiley, HS1
Davis, WL; Jones, RG1
Snyder, RA; Watt, KW; Wintroub, BU1
Bakshian, S; Baldassare, JJ; Fisher, GJ; Knipp, MA1
Goris, J; Merlevede, W; Waelkens, E1
Connolly, TP; Dunn, WA; Hubbard, AL1
Harford, JB; Klausner, RD; Rao, K; Weissman, AM1
Carlino, JA; Niu, EM; Sherman, MR; Stevens, YW; Tuazon, FB1
Hincke, MT; Tolnai, S1
Horecker, BL; Melloni, E; Michetti, M; Pontremoli, S; Sacco, O; Salamino, F; Sparatore, B2
Kosaki, G; Suzuki, K; Tanoue, K; Yamamoto, K; Yamazaki, H1
Croall, DE; DeMartino, GN; Morrow, JS1
Connold, AL; Evers, JV; Vrbová, G1
Mykles, DL; Skinner, DM1
Bokemeyer, C; Gabius, HJ; Hellmann, T; Schmoll, HJ1
Davidson, S; Klagsbrun, M; Sasse, J; Shing, Y; Smith, JA; Smith, S; Sullivan, R1
Billett, EE; Earl, RT; Hunneyball, IM; Mayer, RJ1
Davies, KJ1
Swanson, GJ; Vrbová, G1
Ballard, FJ; Chandler, CS1
Aikawa, M; Leech, JH; McKerrow, JH; Nagasawa, H; Rosenthal, PJ1
Heidland, A; Kulzer, P; Leibold, J; Peter, G; Schaefer, RM; Teschner, M2
Hazama, R; Kinoshita, N; Mori, M; Nagataki, S; Satoh, A; Takashima, H; Tsujihata, M; Yoshimura, T1
Ito, M; Katunuma, N; Kominami, E; Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Toshima, K1
Galjaard, H; Hoogeveen, AT; Sips, HJ; van Dongen, JM; Willemsen, R1
Ahsan, A; Bain, DL; Ostrowski, LE; Pagast, P; Patel, A; Schultz, RM; Suthar, BP; Wong, C1
Furuno, K; Goldberg, AL1
Katsunuma, N; Morita, K; Nakanishi, A; Oka, M1
Iizuka, H; Iwasaki, Y; Konno, H; Yamamoto, H; Yamamoto, T1
Hibino, T; Sato, K; Yokozeki, H1
Lentze, MJ; Naim, HY; Sterchi, EE1
Chiou, WJ; Kovacic-Milivojević, B; LaPointe, MC; Reker, CE; Vedeckis, WV1
Fisher, RR; Lubin, IM; Wu, LN1
d'Azzo, A; Giudice, C; Hoogeveen, AT; Lijoi, S; Parenti, G; Strisciuglio, P1
Cardelli, JA; Dimond, RL; Ebert, DL; Richardson, JM; Woychik, NA1
Faragó, A; Seprõdi, J; Spät, A1
Akagi, S; Masaki, R; Ogawa, R; Tashiro, Y; Yamamoto, A; Yoshimori, T1
Bomford, A; Roberts, S1
Khan, KM; Natori, Y; Okada, M; Sato, A1
Hamilton, G; Karner, J; Kovats, E; Ollenschläger, G; Roth, E; Simmel, A1
Karner, J; Kovats, E; Ollenschläger, G; Roth, E; Simmel, A1
Schaudies, RP; Wray, HL1
Alvarez-Azaustre, E; Hamilton, RT; Jang, YJ; Nilsen-Hamilton, M1
Factorovich, Y; Puri, J1
Bauer, A; Kirchner, H; Rutenfranz, I1
Grandt, R; Jakobs, KH1
Blum, JS; Cresswell, P1
Klenk, HD; Rott, R; Tashiro, M1
Lehmann, A1
Fischer, JE; Hasselgren, PO; Hummel, RP; James, JH; Warner, BW2
Christen, P; Flückiger, J1
Hoppe, W; Kresse, H; Rauch, U1
Catalfamo, JL; Fareed, J; Fenton, JW; Pouliott, C; Witting, JI1
Chang, VK; Kaldany, RR; Maccabee, PJ; Stracher, A; Valderrama, R1
Bridges, KR; Hoffman, KE1
Cakiroglu, AG; Jackson, JF; Marks, PA; Melloni, E; Michetti, M; Pontremoli, S; Rifkind, RA; Sacco, O1
Coffey, RJ; Kost, LJ; LaRusso, NF; Lyons, RM; Moses, HL1
Currie, DD; Garte, SJ; Troll, W1
Endo, N; Hara, T; Kato, Y; Kishida, K; Saito, M; Takeda, Y; Umemoto, N2
Lindquist, RN; McKerrow, J; Petitt, M; Senft, AW1
Iizuka, H; Iwasaki, Y; Kadoya, S; Yamamoto, T1
Kooistra, T; Lloyd, JB3
Ahsan, A; Ostrowski, LE; Pagast, P; Persky, B; Schultz, RM1
Danzo, BJ1
Taurog, A; Yoshinari, M2
Abramovitz, AS; Margolis, JW; Wagner, BJ1
Dluzewski, AR; Gratzer, WB; Rangachari, K; Wilson, RJ1
Ikeno, K; Ikeno, T; Ishiguro, I; Kuzuya, H1
Aerts, JF; Barranger, JA; Ginns, EI; Jonsson, LM; Murray, GJ; Schram, AW; Sorrell, SH; Strijland, A; Tager, JM1
Goto, I; Kuroiwa, Y; Shinno, N1
Itoh, N; Okada, Y; Okamoto, H; Teno, N; Tsuboi, S1
Davis, JL; Pico, RM1
Doherty, FJ; Mayer, RJ; Wassell, JA1
Kato, H; Naito, H; Noguchi, T; Takahashi, A; Takahashi, S1
Beertsen, W; Everts, V1
Beckenbauer, T; Kugler, P1
Ishii, S; Murao, S; Numakunai, T; Yokosawa, H1
Badalamente, MA; Hurst, LC; Paul, SB; Stracher, A1
Kasayama, S; Kishimoto, S; Matsumoto, K; Nakao, M; Nishizawa, Y; Noma, K; Sato, B1
Bridges, KR1
Ruda, EM; Scrutton, MC1
Ahlberg, J; Glaumann, H1
Cox, CA; Rao, GH; White, JG1
Nakagawa, H; Tsurufuji, S; Watanabe, K1
Bression, D; Le Dafniet, M; Michard, M; Pagesy, P; Peillon, F1
Kugler, P; Miki, A1
Decker, RS; Ridout, RM; Wildenthal, K1
Fukuyo, T; Hara, S; Hayasaka, S; Mizuno, K; Nakazawa, M1
Beynon, RJ; Ning, MC1
Ishibashi, M; Miyazaki, H; Mizuguchi, S; Takayama, H; Tanaka, W; Umezawa, H; Watanabe, K; Yamashita, K1
Kirwin, P; Mayer, RJ; O'Hare, M; Razooki-Hasan, H; White, DA; Wilde, C1
Capony, F; Morisset, M; Rochefort, H1
Dresden, MH; Xu, YZ1
Pick, E; Toper, R1
Ascoli, M; Segaloff, DL1
Ahlberg, J; Berkenstam, A; Glaumann, H; Henell, F3
Gagnon, C; Veeraragavan, K1
Hsieh, LC; Markland, FS; Su, C1
Bernstein, PL; Etlinger, JD; Ludemann, R; Zeman, RJ1
Ichikawa, S; Murao, S; Oda, K; Shibata, T; Takehara, Y; Tamada, H2
Faraday, R; Lynch, G; Stäubli, U1
Ballard, FJ1
Grimmecke, HD; Schönborn, C; Wand, H1
Bogitsh, BJ; Kramer, JD1
Ishiura, S; Kamakura, K; Sano, M; Sugita, H1
Wakeland, JR; Wildenthal, K1
Oude Elferink, RP; Reuser, AJ; Strijland, A; Tager, JM; Van Doorn-Van Wakeren, J1
Fukuyo, T; Hayasaka, S; Mizuno, K1
Authi, KS; Crawford, N; Lagarde, M1
Jenkins, CS; Ores-Carton, C; Puszkin, EG; Zucker, MB1
Odessey, R1
Hamilton, JW; Jilka, RL1
Mitchell, EJ; Zimmerman, AM1
Etlinger, JD; Silver, G1
Banerjee, A; Burg, J; Sandhoff, K1
Ireland, ME; Treisman, GJ; Welsh, MJ1
Llados, FT1
van Tol, A; van't Hooft, FM1
Fisher, MM; Jones, AL; Schiff, JM; Underdown, BJ1
Appleyard, G; Tisdale, M1
Kovács, AL; Kovács, J; László, L1
Conrad, SM; Lorand, L; Velasco, PT1
Glaumann, H; Henell, F1
Johansson, S; Pertoft, H; Smedsrød, B1
Aronson, NN; Dennis, PA3
Baudry, M; Lynch, G; Stäubli, U2
Ishii, S; Katoh, K; Miyazaki, H; Saino, T; Someno, T1
Yanagishita, M1
Brown, NA; Freeman, SJ1
Robbins, N; Rochel, S1
Mort, JS; Recklies, AD1
Kempen, HJ; Kruijt, JK; van Berkel, TJ1
Iizuka, H; Iwasaki, Y; Kadoya, S; Konno, H; Yamamoto, T1
Beertsen, W; Everts, V; Tigchelaar-Gutter, W1
Klein, T; Potgieter, HC; Savage, N; Spies, JH; van der Watt, JJ1
Andersen, KB1
Berg, T; Blomhoff, R; Ford, T; Kindberg, GM1
Ishii, S; Kawahigashi, M; Sawada, H; Yokosawa, H1
Ishida, J; Kai, M; Miura, T; Ohkura, Y1
Ahlberg, J; Berkenstam, A; Falk, M; Glaumann, H; Henell, F1
Khairallah, EA1
Hamet, P; Tremblay, J1
Hatanaka, M; Kannagi, R; Murachi, T; Murakami, T; Yoshimura, N1
Grinde, B; Jahnsen, R1
Hashida, S; Katunuma, N; Khairallah, EA; Kominami, E1
Baudry, M; Lynch, G1
Chang, TM; Kullberg, DW1
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Baum, MA; Hammond, TG; Harris, HW; Puliyanda, DP; Ward, DT1
Fuertes, G; Knecht, E; Villarroya, A1
Ailawadi, G; Bishop, K; Ford, JW; Hannawa, KK; Henke, PK; Knipp, BS; Lu, G; Roelofs, KJ; Stanley, JC; Thanaporn, P; Upchurch, GR1
Chau, YP; Chen, JH; Lin, SY; Tai, MH1
Agriello, E; Corigliano, A; Etchepareborda, E; Fainboim, L; García, V; Irigoyen, M; Pasanante, G; Ramhorst, R1
Anniko, M; Shimizu, A; Suzuki, M; Takumida, M1
Bonneau, O; Corteling, R; Ferretti, M; Ferretti, S; Trifilieff, A1
Ogata, T1
Beis, I; Gaitanaki, C; Papazafiri, P1
De Tullio, R; Melloni, E; Pontremoli, S; Salamino, F; Stifanese, R1
Lauffenburger, DA; Luo, JH; Mamoune, A; Wells, A1
Chen, HQ; Chen, P; He, SH1
Chokki, M; Eguchi, H; Horiuchi, H; Kamimura, T; Masegi, T; Tanabe, H; Yamamura, S; Yasuoka, S1
Na, BK; Pandey, KC; Rosenthal, PJ; Sijwali, PS; Singh, A1
Honma, K; Kuramitsu, HK; Miyakawa, H; Qi, M1
Gwiazda, Z; Mussur, M; Rudziński, T1
Brustis, JJ; Cottin, P; Dargelos, E; Dedieu, S; Grise, F; Mazères, G; Poussard, S1
Belenky, A; Bluestein, BI; Despres, N; Lin, S; Smith, A; Wu, AH; Zhang, B1
Birss, AJ; Silver, J; Smalley, JW; Thomas, MF; Withnall, R1
Bax, M; Hessel, M; Li, L; van der Laarse, A; van der Linden, I; van der Valk, L1
Biswas, S; Chakrabarti, C; Dattagupta, JK; Jagannadham, MV; Sundd, M; Thakurta, PG1
Ecarnot-Laubriet, A; Perrin, C; Rochette, L; Vergely, C1
Greensmith, L; Kieran, D1
Balough, BJ; Finley, JC; Gottshall, KR; Hoffer, ME; Killian, P; Shulman, A; Wester, D1
Chandad, F; Duncan, L; Grenier, D; Yoshioka, M1
Du, R; Li, XD; Liu, H; Pan, WS; Tang, R1
Chopin, C; Depontieu, F; Lancel, S; Marechal, X; Mordon, S; Neviere, R; Scherpereel, A; Tissier, S1
Chohan, PK; Dhalla, NS; Netticadan, T; Singh, RB1
Asano, M; Matsumoto, N; Moro, I; Nomura, H; Ogura, Y; Suguro, H; Takenouchi-Ohkubo, N1
Alavez, S; Cameron, LC; Casaletti, L; Franco-Cea, A; Morán, J; Ortega-Gómez, A1
Nakamatsu, Y; Tanaka, T1
Blat, Y; Pedicord, DL; Seiffert, D1
Carrillo, E; Galindo, JM; García, MC; Sánchez, JA1
Campbell, RL; Cuerrier, D; Davies, PL; Moldoveanu, T1
Fujisaki, K; Islam, KM; Kamio, T; Miyoshi, T; Tsuji, N1
Cheng, MH; Fu, YL; He, SH; Xie, H1
Lim, CJ; Shen, WC1
Bonjardim, CA; Brasil, BS; De Sousa, LP; Ferreira, PC; Freitas, MH; Kroon, EG; Nogueira, SV; Silva, BM1
McCaslin, DR; Schechter, NM; Selwood, T; Smolensky, H1
Castro-Borges, W; Evangelista, EA; Guerra-Sá, R; Kettelhut, IC; Rodrigues, V1
Gong, Q; Keeney, DR; Molinari, M; Zhou, Z1
Ebihara, T; Hattori, S; Irie, S; Matsubara, Y; Miura-Yokota, Y1
An, S; Hishikawa, Y; Koji, T1
Kokai, M; Maeda, S; Morita, Y; Nakajima, T; Nishii, R; Ohara, K; Seki, M; Takanaga, A; Takauchi, S; Takeda, M; Tanaka, T1
Brunk, UT; Dalen, H; Stroikin, Y; Terman, A1
Ogura, Y1
Ducasse, C; Enjolras, N; Guillet, B; Négrier, C; Plantier, JL; Rodriguez, MH; Rolli, V1
Karata, K; Lu, J; Matsushita, K; Sugaya, S; Suzuki, N; Suzuki, T; Takahashi, S; Tong, XB; Zhang, HC; Zhu, CL1
de la Cruz Hernandez-Hernandez, F; Rodriguez, MC; Rodriguez, MH; Torres, JA1
Maezawa, H; Matsushima, R; Miki, M; Nakamura, Y; Nakaya, Y; Ohgushi, F; Takahashi, A; Yasuoka, S1
Basu, SK; Kim, KJ; Lee, VH; Sun, L1
Akagi, M; Fukuishi, N; Imajo, N; Matsui, N; Okikawa, T; Yasui, Y1
Asano-Kato, N; Dogru, M; Fujishima, H; Fukagawa, K; Okada, N; Tsubota, K1
Alviano, CS; Branquinha, MH; d'Avila-Levy, CM; Dias, FA; Elias, CG; Lopes, AH; Pereira, FM; Ribeiro, RO; Santos, AL; Soares, RM; Souto-Padrón, T1
Alcaide-Hidalgo, JM; de Boer, AR; Irth, H; Kolkman, J; Krabbe, JG; Lingeman, H; Niessen, WM; van Emde Boas, CN1
Andoh, T; Kuraishi, Y; Lee, JB; Nojima, H; Ui, H1
Bode, W; Huber, R; Marquardt, U; Rohr, KB; Schechter, NM; Selwood, T; Than, ME1
Corbett, L; Knox, AJ; Nie, M; Pang, L; Sutcliffe, A1
Kidane, TZ; Linder, MC; Sauble, E1
Imanaga, I; Lin, H; Ogawa, K; Tribulova, N1
Futai, K; Hashimoto, T; Matsubara, A; Momiyama, J; Namba, A; Shinkawa, H1
Kanje, M; Momeni, HR1
Davies, JP; Hosokawa, H; Ioannou, YA; Ninomiya, H; Ohno, K; Ohsaki, Y; Sugimoto, Y; Suzuki, M; Vanier, MT; Yoshimori, T1
Bethune, MT; Khosla, C; Sollid, LM; Strop, P; Tang, Y1
Gehrig-Burger, K; Krämer-Albers, EM; Nave, KA; Thiele, C; Trotter, J1
Calamita, G; Carreras, FI; Ferri, D; Lehmann, GL; Marinelli, RA; Tioni, MF1
Berman-Frank, I; Eisenstadt, D; Kaplan, A; Levine, A; Murik, O; Vardi, A; Zohary, T1
Inoue, N; Nikai, T; Okumura, Y1
Hällbrink, M; Jayamanne, M; Kjellander, M; Palm, C1
Furuya, H; Harayama, Y; Imanaka, T; Kashiwayama, Y; Maeda, T; Morita, M; Sato, R; Shimozawa, N; Suzuki, Y; Takahashi, N1
Alhassan, A; Govind, Y; Igarashi, I; Okubo, K; Yokoyama, N1
Chen, SC; Chou, Y; Tian, TY; Tsai, CH; Ueng, KC; Yeh, HI1
Leppla, SH; Moayeri, M; Wiggins, JF1
Ahn, SJ; Chung, JK; Hong, YK; Jang, JH; Jeon, SJ; Kim, KH; Kim, MS; Kim, NY; Lee, HH; Seo, JS1
Bode, W; Debela, M; Goettig, P; Huber, R; Magdolen, V; Schechter, NM1
Han, Y; Hu, WB; Liu, A; Liu, MX; Quan, GB; Wang, JX; Wang, Y; Yang, C1
de Boer, TP; Jansen, JA; van der Heyden, MA; van Rijen, HV; van Veen, TA; Vos, MA; Wolswinkel, R1
Corona, JC; Tapia, R1
Brown, SA; Chaka, W; Cresswell, P; Hurwitz, JL; Sealy, R; Surman, S1
Rui, Q; Wang, XY; Xu, LL; Zhang, LF; Zhang, P1
Longhi, R; Marturano, J; Protti, MP; Russo, V1
Jenkins, G; Knox, A; Pang, L; Porte, J; Tatler, AL1
Dorn, R; Hausott, B; Klimaschewski, L; Schlick, B; Vallant, N1
Geetha, T; Wooten, MW1
Bolen, JB; Burkhardt, AL1
Desai, SA; Fay, MP; Furuya, T; Gluzman, IY; Goldberg, DE; Kambhampati, S; Lisk, G; Pain, M; Su, XZ1
Allen, DG; Qin, L; Yeung, EW; Yeung, SS; Zhang, BT1
Cataldo, AM; Kumar, A; Levy, E; Nixon, RA; Pawlik, M; Peterhoff, CM; Peterson, J; Stavrides, P; Yang, DS1
Fujiwara, H; Fujiwara, T; Goto, K; Horie, T; Kanamori, H; Maruyama, R; Minatoguchi, S; Miyata, S; Nagao, K; Nagashima, K; Ono, K; Takemura, G; Tsujimoto, A; Ushikoshi, H1
Bengtsson, T; Grenegård, M; Lindahl, TL; Nylander, M1
Branquinha, MH; d'Avila-Levy, CM; Dias, FA; Elias, CG; Lopes, AH; Pereira, FM; Santos, AL; Silva, TL1
Andrysík, Z; Kozubík, A; Krcmár, P; Machala, M; Simecková, P; Vondrácek, J; Zatloukalová, J1
Benke, D; Broll, I; Fischer, N; Grampp, T; Notz, V1
Judge, AR; McClung, JM; Powers, SK; Talbert, EE1
Brinen, LS; Harrison, A; Kerr, ID; Lee, JH; Pandey, KC; Rosenthal, PJ; Sajid, M1
Acker, JP; Kanias, T1
Chapman, D; Dhalla, NS; Elimban, V; Maddika, S1
Kim, YS; Kwon, HJ; Lee, HK1
Kozubík, A; Krcmár, P; Machala, M; Procházková, J; Simecková, P; Vondrácek, J1
Andreola, ML; Baranova, SV; Buneva, VN; Calmels, C; Kharitonova, MA; Nevinsky, GA; Parissi, V; Sizyakina, LP1
Arancibia-Cárcamo, IL; Kittler, JT; Lumb, MJ; Michels, G; Moss, SJ; Muir, J; Saliba, RS; Smart, TG; Yan, Z; Yuen, EY1
Craig, MJ; Pienta, KJ; Roca, H; Sud, S; Varsos, ZS; Ying, C1
Eden, ER; Futter, CE; Tsapara, A; White, IJ1
Hu, Y; Itoh, Y; Morioka, K1
Li, W; Li, Y; Mikhael, M; Nie, G; Ning, B; Ponka, P; Soe-Lin, S; Xu, D; Zhang, Y; Zhao, Y1
Dickey, DM; Potter, LR2
Hayakawa, T; Kawase, N; Kishi, J; Nakamura, H1
Bonafè, F; Bonavita, F; Caldarera, CM; Capanni, C; Giordano, E; Guarnieri, C; Muscari, C; Stanic, I; Stefanelli, C1
Acosta, P; Barton, E; Carver, T; Pendrak, K; Pham, J; Selsby, J; Sweeney, HL; Tian, Z; Zadel, M1
Maemoto, Y; Maki, M; Osako, Y; Shibata, H; Suzuki, H; Tanaka, R1
Bai, B; Jäämaa, S; Laiho, M; Latonen, L; Moore, HM1
Moczoń, T1
He, S; Ma, W; Yang, H; Zhang, H1
Dawson, G; Qin, J1
Abaamrane, L; Raffin, F; Schmerber, S; Sendowski, I1
Agudelo, J; Bates, P; Bertram, S; Chaipan, C; Glowacka, I; Hofmann, H; Lu, K; Pöhlmann, S; Rennekamp, AJ; Simmons, G; Steffen, I1
Choi, AM; Dolinay, T; Englert, JA; Haspel, J; Ifedigbo, E; Nakahira, K; Shaik, RS1
Hagen, LK; Johansen, HT; Seglen, PO; Sætre, F; Øverbye, A1
Aravind, L; Bokhari, AA; Desai, SA; Nguitragool, W; Pillai, AD; Rayavara, K; Sharma, P; Turpin, B1
Ezaki, J; Kominami, E; Ueno, T1
Chao, J; Zhang, J; Zhou, J1
Huang, F; Huang, M; Ma, H; Xu, X; Zhou, G1
Haugsten, EM; Hausott, B; Hochfilzer, M; Irschick, R; Klimaschewski, L; Mangger, S; Vallant, N1
Fine, DH; Furgang, D; Ganeshnarayan, K; Velliyagounder, K1
Ahmad, F; Blaesse, P; Kaila, K; Puskarjov, M1
Auer, M; Claus, P; Hausott, B; Irschick, R; Karp, G; Klimaschewski, L; Trost, T1
Chakraborti, S; Chakraborti, T; Das, S; Mandai, M1
Bengtsson, T; Khalaf, H1
Brown, TC; Esteban, JA; Fernández-Monreal, M; Royo, M1
Haydon, J; Jacob, TC; Michels, G; Moss, SJ; Silayeva, L; Succol, F1
Akiyama, Y; Matsubara, T; Matsuda, T; Nadano, D; Okajima, T; Oshima, K1
Coffin, AB; Mamiya, A; Raible, DW; Rubel, EW; Williamson, KL1
Dolinoy, DC; Harris, C; Nahar, MS; Sant, KE1
Ahmad, H; Alam, SM; Chou, YW; Kumar, S; Lin, MF; Muniyan, S; Zhang, L1
Coulter, WA; Irwin, CR; Lundy, FT; Manning, G; McCrudden, MT; Orr, DF; Yu, Y1
Furuichi, Y; Nagasawa, T; Nakatsuka, Y; Nakazawa, F; Yumoto, Y1
Hausner, T; Hausott, B; Hopf, R; Klimaschewski, L; Márton, G; Marvaldi, L; Nógrádi, A; Pajer, K; Redl, H; Schmidhammer, R1
Cascio, P; Cerruti, F; Raule, M1
Leclerc, N; Mohamed, NV; Planel, E; Plouffe, V; Rémillard-Labrosse, G1
Fewer, DP; Jokela, J; Liu, L; Nowruzi, B; Permi, P; Sivonen, K; Wahlsten, M; Xhaard, H; Zhang, YZ1
Erhardt, J; Jazvinšćak Jembrek, M; Oršolić, N; Radovanović, V; Vlainić, J1
Bresgen, N; Eckl, PM; Krenn, MA; Schürz, M; Teufl, B; Uchida, K1
Boya, P; Esteban-Martínez, L1
Carney, EW; Johnson, KJ; Marshall, VA; Moore, NP; Rasoulpour, RJ; Tornesi, B1
Hilty, C; Kim, Y1
Basore, K; Desai, SA; Ito, D; Rayavara, K; Sharma, P1
Hansen, JM; Harris, C; Jilek, JL; Pohl, J; Reed, M; Sant, KE1
Kamemura, N; Kido, H; Matsumoto, K; Morita, H; Saito, H; Takashima, M1
Blanco, A; Cuchacovich, M; Cuchacovich, S; Francos, R; Gomez, CF; Gonzalez-Gronow, M; Pizzo, SV; Ray, R; Sandoval, R; Valenzuela, JA1
Kuver, A; Smith, SS1
Baccarini, S; Cagnin, M; De Luca, G; Dogliotti, E; Falchi, M; Ferretti, C; Fortini, P; Garribba, L; Iorio, E; Isidoro, C; Morani, F; Pascucci, B; Phadngam, S; Pietraforte, D1
Garner, B; Li, H; Ruberu, K; Zhao, H1
Bennett, MV; Court-Vazquez, B; Gertner, M; Hwang, JY; Ofengeim, D; Pontarelli, F; Zukin, RS1
Hashimoto, Y1
Chiou, HC; Hsiao, PJ; Hsieh, TJ; Jiang, HJ; Kuo, KK; Lee, MY1
Billinger, E; Johansson, G1
Kelleher, NL; McClure, RA; Mullowney, MW; Robey, MT; Thomson, RJ1
Biniossek, ML; Bode, W; Brandstetter, H; Craik, CS; Debela, M; Elsässer, B; Goettig, P; Magdolen, V; Schilling, O; Schneider, EL; Skala, W1
Chauhan, S; Dugue, R; Goodman, JH; Hassen, GW; Ling, DSF; Michelson, H; Serrano, P; Shulman, A1
Campbell, RL; Davies, PL; McCartney, CE; Ye, Q1
Jia, L; Qiu, Y; Yao, J; Zacks, DN1
Beekman, C; Bennett, RJ; Jiang, Z; Knudsen, GM; Lindner, DL; O'Donoghue, AJ; Palmer, JM; Suzuki, BM1
Engedal, N; Luhr, M; Seglen, PO; Szalai, P1
Komatsu, M; Ueno, T1
Cuervo, AM; Juste, YR1
Altawallbeh, G; Brodsky, JL; Cao, R; Cotton, C; Estabrooks, SK; Gaston, B; Getsy, P; Holloway, K; Hussain, F; Jafri, A; Knight, J; Lewis, SJ; Li, Y; Periasamy, A; Raffay, T; Sawczak, V; Sun, F; Zaman, K1
Aulhorn, S; Gündel, U; Kalkhof, S; Küster, E; von Bergen, M1
Andreae, EA; Twining, SS; Warejcka, DJ1
Arafa, FM; Elkerdany, ED; Elnassery, SM; Mady, RF; Zaki, SA1
Akakpo, JY; Ding, WX; Jaeschke, H; Nguyen, NT; Ramachandran, A; Weemhoff, JL1
Chinnasamy, K; Iruthayaraj, A; Kandasamy, S; Magudeeswaran, S; Poomani, K; Ramakrishnan, J1
Feng, Y; Fu, L; Gao, GF; Huang, B; Li, X; Niu, P; Qi, J; Shao, S; Sun, X; Tan, W; Wang, Q; Wong, CCL; Ye, F; Yu, F1

Reviews

8 review(s) available for leupeptin and leupeptins

ArticleYear
Transport and expression of HLA class-II glycoproteins.
    Immunologic research, 1990, Volume: 9, Issue:3

    Topics: B-Lymphocytes; Cell Line; Endocytosis; Endopeptidases; Gene Expression Regulation; Genes, MHC Class II; HLA-D Antigens; Humans; Leupeptins; Membrane Glycoproteins; Protein Processing, Post-Translational

1990
Quantitative aspects of cellular autophagocytosis. Morphometric and cell fractionation studies.
    Revisiones sobre biologia celular : RBC, 1989, Volume: 20

    Topics: Animals; Autophagy; Cell Compartmentation; Cell Fractionation; Chloroquine; Leupeptins; Liver; Lysosomes; Male; Methylamines; Pancreas; Phagocytosis; Rats; Seminal Vesicles; Vacuoles; Vinblastine

1989
"Defective" receptors in steroid-resistant conditions may be proteolytic artifacts.
    Advances in experimental medicine and biology, 1986, Volume: 196

    Topics: Animals; Breast; Breast Neoplasms; Centrifugation, Density Gradient; Cytosol; Drug Resistance; Endometrium; Endopeptidases; Female; Humans; Kidney; Leukemia; Leupeptins; Liver; Lysine; Macromolecular Substances; Male; Molybdenum; Osmolar Concentration; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Substrate Specificity; Ultracentrifugation; Uterine Neoplasms

1986
Calcium-dependent proteolytic stimulation of adenylate cyclase in platelets from spontaneously hypertensive rats.
    Metabolism: clinical and experimental, 1984, Volume: 33, Issue:8

    Topics: Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Calcium; Calmodulin; Cyclic AMP; Enzyme Activation; Epinephrine; Humans; Hypertension; Leupeptins; Peptide Hydrolases; Platelet Aggregation; Prostaglandins E; Rats; Rats, Inbred Strains; Renin

1984
Are proteinase inhibitors potentially useful in tumor therapy?
    Invasion & metastasis, 1982, Volume: 2, Issue:2

    Topics: Animals; Antipain; Aprotinin; Blood Coagulation; Cathepsin B; Cathepsin D; Cathepsins; Endopeptidases; Humans; Leupeptins; Microbial Collagenase; Neoplasms; Pancreatic Elastase; Plasminogen Activators; Protease Inhibitors

1982
Calpain inhibitors as therapeutic agents in nerve and muscle degeneration.
    Annals of the New York Academy of Sciences, 1999, Nov-28, Volume: 884

    Topics: Animals; Glycoproteins; Hair Cells, Auditory; Haplorhini; Hearing Loss, Noise-Induced; Leupeptins; Mice; Mice, Inbred C57BL; Muscular Dystrophy, Animal; Nerve Degeneration; Spiral Ganglion

1999
Peroxisome degradation in mammals.
    IUBMB life, 2011, Volume: 63, Issue:11

    Topics: Animals; Arachidonate 15-Lipoxygenase; Autophagy; Cells, Cultured; Half-Life; Humans; Hypolipidemic Agents; Leupeptins; Mammals; Peroxisomes; Protease La; Ubiquitination

2011
Natural products from thioester reductase containing biosynthetic pathways.
    Natural product reports, 2018, 09-19, Volume: 35, Issue:9

    Topics: Alkaloids; Azabicyclo Compounds; Benzodiazepinones; Biological Products; Biosynthetic Pathways; Cyclization; Depsipeptides; Dipeptides; Indoles; Lactams; Leupeptins; Lysine; Multigene Family; Peptide Synthases; Polyketide Synthases; Protein Domains

2018

Other Studies

885 other study(ies) available for leupeptin and leupeptins

ArticleYear
Giant sarcoplasmic reticulum vesicles: a study of membrane morphogenesis.
    Journal of muscle research and cell motility, 1992, Volume: 13, Issue:5

    Topics: Animals; Antipain; Aprotinin; Calcium-Transporting ATPases; Crystallization; Egtazic Acid; Lanthanum; Leupeptins; Liposomes; Membrane Fusion; Membrane Proteins; Microscopy, Electron; Morphogenesis; Muscle Proteins; Proteolipids; Rabbits; Sarcoplasmic Reticulum; Temperature; Vanadates

1992
Differences in alpha 2u-globulins increased in male rat kidneys following treatment with several alpha 2u-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type-alpha 2u-globulin.
    Toxicology, 1992, Nov-30, Volume: 76, Issue:2

    Topics: Alpha-Globulins; Animals; Chlorobenzenes; Cyclohexanones; Cyclohexenes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Kidney; Leucine; Leupeptins; Limonene; Male; Naphthalenes; Octanes; Rats; Rats, Sprague-Dawley; Terpenes

1992
Protease activities in carp retina.
    Neurochemistry international, 1992, Volume: 21, Issue:4

    Topics: Amino Acid Sequence; Animals; Carps; Coumarins; Endopeptidases; Hydrogen-Ion Concentration; Leucine; Leupeptins; Molecular Sequence Data; Peptides; Phenanthrolines; Protease Inhibitors; Retina; Serine Endopeptidases; Tosyllysine Chloromethyl Ketone

1992
Synthesis and brush border expression of intrinsic factor-cobalamin receptor from rat renal cortex.
    The Journal of biological chemistry, 1992, Apr-15, Volume: 267, Issue:11

    Topics: Animals; Chloroquine; Chromatography, Liquid; Culture Techniques; Electrophoresis, Polyacrylamide Gel; Intrinsic Factor; Kidney Cortex; Leupeptins; Male; Microvilli; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Vitamin B 12

1992
Separation, purification and N-terminal sequence analysis of a novel leupeptin-sensitive serine endopeptidase present in chemically induced rat mammary tumour.
    The Biochemical journal, 1992, Apr-01, Volume: 283 ( Pt 1)

    Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Benzoylarginine Nitroanilide; Chromatography, Gel; Electrophoresis; Enzyme Activation; Enzyme Stability; Female; Hydrogen-Ion Concentration; Hydrolysis; Isoelectric Point; Leupeptins; Mammary Neoplasms, Experimental; Methylnitrosourea; Molecular Sequence Data; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Substrate Specificity; Tissue Extracts

1992
Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events.
    Virology, 1992, Volume: 189, Issue:1

    Topics: Leupeptins; Models, Biological; Murine hepatitis virus; Peptide Fragments; Precipitin Tests; Protein Biosynthesis; Protein Precursors; Protein Processing, Post-Translational; Reading Frames; Time Factors; Viral Proteins

1992
Metabolism of omega-conotoxin-sensitive voltage-operated calcium channels in human neuroblastoma cells: modulation by cell differentiation and anti-channel antibodies.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:9

    Topics: Antibodies; Calcium Channels; Cell Differentiation; Chloroquine; Electrophysiology; Humans; Leupeptins; Neuroblastoma; omega-Conotoxins; Peptides, Cyclic; Temperature

1992
Role of cathepsin D in antigen presentation of ovalbumin.
    Journal of immunology (Baltimore, Md. : 1950), 1992, Nov-01, Volume: 149, Issue:9

    Topics: Animals; Antigen-Presenting Cells; Cathepsin B; Cathepsin D; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Histocompatibility Antigens Class II; In Vitro Techniques; Interleukin-2; Leupeptins; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Ovalbumin; Pepstatins; T-Lymphocytes

1992
Endocytosis and lysosomal delivery of tissue plasminogen activator-inhibitor 1 complexes in Hep G2 cells.
    Blood, 1992, Dec-01, Volume: 80, Issue:11

    Topics: Ammonium Chloride; beta-N-Acetylhexosaminidases; Carcinoma, Hepatocellular; Chloroquine; Endocytosis; Humans; Kinetics; Leupeptins; Liver Neoplasms; Lysosomes; Pepstatins; Plasminogen Activator Inhibitor 1; Primaquine; Recombinant Proteins; Subcellular Fractions; Tissue Plasminogen Activator; Tumor Cells, Cultured

1992
Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain.
    Annals of the New York Academy of Sciences, 1992, Dec-31, Volume: 674

    Topics: Aging; Alzheimer Disease; Animals; Brain; Dolichols; Endopeptidases; Humans; Immunologic Techniques; Intermediate Filaments; Leucine; Leupeptins; Lipofuscin; Macaca fascicularis; Male; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Ubiquitins

1992
Regulated expression of the tyrosine hydroxylase gene by membrane depolarization. Identification of the responsive element and possible second messengers.
    The Journal of biological chemistry, 1992, Apr-15, Volume: 267, Issue:11

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Cell Line; Chloramphenicol O-Acetyltransferase; Drug Interactions; Enzyme Activation; Gene Expression Regulation, Enzymologic; Ionomycin; Leupeptins; Membrane Potentials; PC12 Cells; Plasmids; Protein Kinase C; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Second Messenger Systems; Sphingosine; Transcription, Genetic; Tyrosine 3-Monooxygenase; Veratridine

1992
Different patterns of protein kinase C redistribution mediated by alpha 1-adrenoceptor stimulation and phorbol ester in rat isolated left ventricular papillary muscle.
    British journal of pharmacology, 1992, Volume: 107, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Leucine; Leupeptins; Male; Myocardial Contraction; Papillary Muscles; Phenylephrine; Phorbol 12,13-Dibutyrate; Protease Inhibitors; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha

1992
Modified immunoradiometric assay of parathyroid hormone-related protein: clinical application in the differential diagnosis of hypercalcemia.
    Clinical chemistry, 1992, Volume: 38, Issue:2

    Topics: Aprotinin; Diagnosis, Differential; Drug Stability; Humans; Hypercalcemia; Immunoradiometric Assay; Leupeptins; Neoplasms; Parathyroid Hormone-Related Protein; Peptide Fragments; Proteins

1992
Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Apr-15, Volume: 89, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Aprotinin; Blotting, Northern; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; DNA Replication; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Leupeptins; Male; Pentoxifylline; Phenylmethylsulfonyl Fluoride; Prostatic Neoplasms; RNA, Neoplasm; Theophylline; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured

1992
Protease inhibitors as a model for NCL disease, with special emphasis on the infantile and adult forms.
    American journal of medical genetics, 1992, Feb-15, Volume: 42, Issue:4

    Topics: Animals; Aprotinin; Ceroid; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dogs; Humans; Leupeptins; Lipofuscin; Lysosomes; Neuronal Ceroid-Lipofuscinoses; Purkinje Cells; Rats; Rats, Inbred Strains

1992
Phenotypic variation of surface antigenic determinants in Trichomonas vaginalis detected by monoclonal antibodies.
    Microbiologica, 1992, Volume: 15, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Protozoan; Antigenic Variation; Antigens, Protozoan; Antigens, Surface; Epitopes; Fluorescent Antibody Technique; Hybridomas; Immunoblotting; Leupeptins; Phenotype; Trichomonas vaginalis

1992
Alterations of the levels of glycoproteins Ib-IX and IIb-IIIa in platelets stored at 22 degrees C.
    Thrombosis research, 1992, Jun-15, Volume: 66, Issue:6

    Topics: Antibodies, Monoclonal; Aprotinin; Blood Platelets; Blood Preservation; Cold Temperature; Humans; Leupeptins; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Ristocetin

1992
Uptake, intracellular transport, and degradation of polyethylene glycol-modified asialofetuin in hepatocytes.
    The Journal of biological chemistry, 1992, Nov-15, Volume: 267, Issue:32

    Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Biological Transport; Cells, Cultured; Chloroquine; Fetuins; Kinetics; Kupffer Cells; Leupeptins; Liver; Polyethylene Glycols; Rats; Time Factors

1992
Unique expression of von Willebrand factor by type IIA von Willebrand's disease endothelial cells.
    British journal of haematology, 1992, Volume: 81, Issue:3

    Topics: Blood Platelets; Blotting, Western; Cells, Cultured; Edetic Acid; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Ethylmaleimide; Female; Humans; Leupeptins; Male; Molecular Weight; Pedigree; von Willebrand Diseases; von Willebrand Factor

1992
Calcium-activated potassium transport and high molecular weight forms of calpromotin.
    The Journal of biological chemistry, 1992, Oct-25, Volume: 267, Issue:30

    Topics: Biological Transport; Blood Proteins; Blotting, Western; Calcium; Cells, Cultured; Chromatography, High Pressure Liquid; Cytoplasm; Erythrocyte Membrane; Humans; Iodoacetates; Iodoacetic Acid; Leupeptins; Molecular Weight; Potassium

1992
Recovery after delayed nerve repair: influence of a pharmacologic adjunct in a primate model.
    Journal of reconstructive microsurgery, 1992, Volume: 8, Issue:5

    Topics: Animals; Axons; Calpain; Cebus; Leupeptins; Median Nerve; Muscles; Muscular Atrophy; Nerve Regeneration; Neural Conduction; Time Factors

1992
Effect of lysosomotropic agents on the taurocholate-stimulated biliary excretion of horseradish peroxidase.
    Biochemical pharmacology, 1992, Oct-20, Volume: 44, Issue:8

    Topics: Acid Phosphatase; Animals; Bile Acids and Salts; Biliary Tract; Chloroquine; Horseradish Peroxidase; Leupeptins; Lysosomes; Male; Rats; Rats, Wistar; Taurocholic Acid

1992
Assembly and secretion of fibrinogen. Degradation of individual chains.
    The Journal of biological chemistry, 1992, Nov-15, Volume: 267, Issue:32

    Topics: Ammonium Chloride; Animals; Cell Line; Chickens; Chloroquine; Fibrinogen; Humans; Kinetics; Leupeptins; Liver; Lysosomes; Macromolecular Substances; Methionine; Sulfur Radioisotopes; Transfection; Tumor Cells, Cultured

1992
The fertilization and development of mouse oocytes following cortical granule discharge in the presence of a protease inhibitor.
    Human reproduction (Oxford, England), 1992, Volume: 7, Issue:7

    Topics: Animals; Blastocyst; Calcimycin; Culture Techniques; Embryo, Mammalian; Embryonic and Fetal Development; Exocytosis; Female; Fertilization; Fertilization in Vitro; Fluorescent Dyes; Insemination, Artificial; Leupeptins; Mice; Oocytes; Superovulation

1992
Opsonized zymosan decreases cytoplasmic motility of alveolar macrophages in dogs.
    Respiration physiology, 1992, Volume: 89, Issue:2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Aminopeptidases; Animals; Calcium; Captopril; Cells, Cultured; Cytoplasm; Dogs; Indomethacin; Leucine; Leupeptins; Macrophages; Phagocytosis; Pulmonary Alveoli; Superoxide Dismutase; Zymosan

1992
Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses.
    Toxicology and applied pharmacology, 1992, Volume: 117, Issue:1

    Topics: Amino Acid Sequence; Animals; Calcimycin; Calpain; Cataract; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Culture Techniques; Cysteine Proteinase Inhibitors; Dipeptides; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Lens, Crystalline; Leucine; Leupeptins; Molecular Sequence Data; Rats; Rats, Sprague-Dawley

1992
A 1H-NMR study of the interactions between rat tissue kallikrein and two peptide inhibitors.
    Biochimica et biophysica acta, 1992, Nov-20, Volume: 1160, Issue:2

    Topics: Amino Acid Sequence; Animals; Kallikreins; Leupeptins; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Sequence Data; Protein Conformation; Rats; Submandibular Gland

1992
Enhanced ex vivo proteolysis of plasma von Willebrand factor in disseminated intravascular coagulation.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1992, Volume: 3, Issue:5

    Topics: alpha-2-Antiplasmin; Antifibrinolytic Agents; Disseminated Intravascular Coagulation; Edetic Acid; Ethylmaleimide; Fibrinolysin; Humans; Leupeptins; Multienzyme Complexes; Protein Conformation; von Willebrand Factor

1992
The effect of protease inhibitors, leupeptin and E64d, on differentiation of C2C12 myoblasts in tissue culture.
    Cellular and molecular biology, 1992, Volume: 38, Issue:5

    Topics: Animals; Calcium; Calpain; Cell Differentiation; Cell Fusion; Culture Techniques; Leucine; Leupeptins; Mice; Muscles; Protease Inhibitors

1992
A block in degradation of MHC class II-associated invariant chain correlates with a reduction in transport from endosome carrier vesicles to the prelysosome compartment.
    Journal of cell science, 1992, Volume: 103 ( Pt 3)

    Topics: Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; Biological Transport; Endocytosis; Histocompatibility Antigens Class II; Humans; Leupeptins; Tumor Cells, Cultured

1992
Proteolytic activation of a single-chain precursor of hepatocyte growth factor by extracellular serine-protease.
    Biochemical and biophysical research communications, 1992, Dec-30, Volume: 189, Issue:3

    Topics: Animals; Autoradiography; Cell Division; Cell Line; CHO Cells; Cricetinae; Cysteine; DNA; Electrophoresis, Polyacrylamide Gel; Fibrinolysin; Hepatocyte Growth Factor; Humans; Leupeptins; Liver; Lung; Methionine; Plasmids; Protein Precursors; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Serine Endopeptidases; Sulfur Radioisotopes; Tissue Plasminogen Activator; Transfection; Urokinase-Type Plasminogen Activator

1992
Identification and localization of a cysteinyl residue critical for the trypsin-like catalytic activity of the proteasome.
    Biochemistry, 1992, Aug-18, Volume: 31, Issue:32

    Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Chymotrypsin; Cyanogen Bromide; Cysteine; Cysteine Endopeptidases; Erythrocytes; Ethylmaleimide; Humans; Kinetics; Leupeptins; Macromolecular Substances; Molecular Sequence Data; Multienzyme Complexes; Myocardium; Peptide Fragments; Peptide Mapping; Proteasome Endopeptidase Complex; Trypsin

1992
Turnover of peroxisomal vesicles by autophagic proteolysis in cultured fibroblasts from Zellweger patients.
    European journal of cell biology, 1992, Volume: 57, Issue:2

    Topics: Adenine; Autophagy; Cell Line; Fibroblasts; Fluorescent Antibody Technique; Humans; Hydrolases; Leupeptins; Lysosomes; Membrane Proteins; Microbodies; Zellweger Syndrome

1992
Calcium-binding protein regucalcin increases calcium-independent proteolytic activity in rat liver cytosol.
    Molecular and cellular biochemistry, 1992, May-13, Volume: 112, Issue:1

    Topics: Animals; Cadmium; Calcium; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Cytosol; Dose-Response Relationship, Drug; Endopeptidases; Intracellular Signaling Peptides and Proteins; Leupeptins; Liver; Male; Rats; Sulfotransferases; Zinc

1992
Serum proteases alter the antigenicity of peptides presented by class I major histocompatibility complex molecules.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Sep-01, Volume: 89, Issue:17

    Topics: Animals; Antigen-Presenting Cells; Cells, Cultured; Cyanogen Bromide; Endopeptidases; In Vitro Techniques; Leucine; Leupeptins; Mice; Molecular Weight; Ovalbumin; Peptides

1992
Stimulation-enhanced 3-O-methylglucose efflux from the frog sartorius: kinetics and properties of the system.
    Biochimica et biophysica acta, 1992, Aug-24, Volume: 1109, Issue:2

    Topics: 3-O-Methylglucose; Animals; Calcium; Cycloheximide; Dipeptides; Electric Stimulation; Humans; Kinetics; Leupeptins; Male; Methylglucosides; Muscles; Phloretin; Rana pipiens; Tetradecanoylphorbol Acetate

1992
Intraventricular infusion of leupeptin decreases Bmax of the D2 receptor in the striatum of young rats.
    Life sciences, 1992, Volume: 50, Issue:19

    Topics: Animals; Corpus Striatum; Injections, Intraventricular; Leupeptins; Male; Protein Binding; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone

1992
Characterization of different proteolytic activities in Trypanosoma brucei brucei.
    Biochimica et biophysica acta, 1992, Mar-20, Volume: 1138, Issue:3

    Topics: Amino Acid Sequence; Animals; Chromatography, Affinity; Chromatography, High Pressure Liquid; Dithiothreitol; Endopeptidases; Glycoproteins; Hydrogen-Ion Concentration; Kinetics; Leucine; Leupeptins; Molecular Sequence Data; Protease Inhibitors; Trypanosoma brucei brucei

1992
Lymphoproliferative activity of Pseudomonas exotoxin A is dependent on intracellular processing and is associated with the carboxyl-terminal portion.
    Infection and immunity, 1992, Volume: 60, Issue:4

    Topics: ADP Ribose Transferases; Animals; Antigen-Presenting Cells; Bacterial Toxins; Cathepsin D; Endopeptidases; Exotoxins; In Vitro Techniques; Leupeptins; Lymphocyte Activation; Mice; Mice, Inbred Strains; Pepstatins; Peptide Mapping; Protein Processing, Post-Translational; Pseudomonas aeruginosa Exotoxin A; T-Lymphocytes; Thymus Gland; Virulence Factors

1992
Aminopeptidase activity of an antitumor antibiotic, C-1027.
    The Journal of antibiotics, 1992, Volume: 45, Issue:1

    Topics: Aminoglycosides; Aminopeptidases; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Apoproteins; Carcinoma, Ehrlich Tumor; Cell Survival; DNA, Neoplasm; Enediynes; Leucine; Leupeptins; Microsomes; Oligopeptides; Peptides; Proteins; Substrate Specificity; Swine; Tumor Cells, Cultured; Ultraviolet Rays

1992
Effect of platelet calpain on normal T-lymphocyte CD43: hypothesis of events in the Wiskott-Aldrich syndrome.
    Blood, 1992, Apr-01, Volume: 79, Issue:7

    Topics: Antigens, CD; Blood Platelets; Calcium; Calpain; Humans; Immunoblotting; Leukosialin; Leupeptins; Models, Biological; N-Acetylneuraminic Acid; Neuraminidase; Platelet Membrane Glycoproteins; Sialic Acids; Sialoglycoproteins; Substrate Specificity; T-Lymphocytes

1992
Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell lines.
    Experimental cell research, 1992, Volume: 200, Issue:1

    Topics: Antipain; Freeze Fracturing; Humans; Intercellular Junctions; Leupeptins; Protein Precursors; Protein Processing, Post-Translational; Tumor Cells, Cultured

1992
Regulation of the functional expression of hexose transporter GLUT-1 by glucose in murine fibroblasts: role of lysosomal degradation.
    Biochemistry, 1992, Jun-16, Volume: 31, Issue:23

    Topics: 3T3 Cells; Animals; Biological Transport; Cell Compartmentation; Chloroquine; Glucose; Hexoses; In Vitro Techniques; Leupeptins; Lysosomes; Membrane Proteins; Mice; Monosaccharide Transport Proteins

1992
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.
    Nature, 1992, Jun-11, Volume: 357, Issue:6378

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Biotin; Cell Membrane; Endothelium, Vascular; Humans; Leupeptins; Lysosomes; Molecular Weight; Peptide Fragments; Umbilical Veins

1992
Role of hepatic lysosomes in the degradation of metallothionein.
    Toxicology and applied pharmacology, 1992, Volume: 115, Issue:1

    Topics: Animals; Cathepsins; Electrophoresis, Polyacrylamide Gel; Leucine; Leupeptins; Liver; Lysosomes; Male; Metallothionein; Pepstatins; Rats; Rats, Inbred Strains

1992
Effects of heparin on osteoclast activity.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1992, Volume: 7, Issue:7

    Topics: Animals; Bone Resorption; Cells, Cultured; Chickens; Chondroitin Sulfates; Culture Media; Cyclosporine; Dextran Sulfate; Heparin; Histamine; Leupeptins; Osteoclasts; Phenytoin; Protamines; Rats

1992
Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate.
    The Journal of biological chemistry, 1992, Aug-15, Volume: 267, Issue:23

    Topics: Amyloid beta-Protein Precursor; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leucine; Leupeptins; Molecular Weight; Peptide Fragments; Transfection

1992
The possible involvement of trypsin-like enzymes in germination of spores of Bacillus cereus T and Bacillus subtilis 168.
    Journal of general microbiology, 1991, Volume: 137, Issue:5

    Topics: Arginine; Bacillus cereus; Bacillus subtilis; Benzoylarginine Nitroanilide; Chromogenic Compounds; Hot Temperature; Hydrolysis; Leupeptins; Spores, Bacterial; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Trypsin

1991
Morphological and functional changes in the enterocyte induced by fructose.
    The Biochemical journal, 1991, Dec-01, Volume: 280 ( Pt 2)

    Topics: Aminopeptidases; Animals; Apolipoprotein A-I; CD13 Antigens; Cell Fractionation; Electrophoresis, Polyacrylamide Gel; Fructose; Glycosylation; Golgi Apparatus; Intestinal Mucosa; Leupeptins; Mannose; Membrane Proteins; Microscopy, Electron; Microvilli; Organ Culture Techniques; Swine

1991
Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with Alzheimer's disease.
    Experientia, 1990, Jan-15, Volume: 46, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Aprotinin; Brain; Endopeptidases; Female; Humans; Kallikreins; Leupeptins; Male; Middle Aged; Molecular Sequence Data; Peptide Hydrolases; Prolyl Oligopeptidases; Serine Endopeptidases

1990
Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes.
    Developmental biology, 1990, Volume: 138, Issue:1

    Topics: Animals; Cell Survival; Chick Embryo; Chloroquine; Curare; Cycloheximide; Dactinomycin; Ganglia, Spinal; Gene Expression; Genotype; Leupeptins; Microscopy, Electron; Motor Neurons; Protein Biosynthesis; Puromycin; RNA; Spinal Cord

1990
Different roles for thiol and aspartyl proteases in antigen presentation of ovalbumin.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Jul-15, Volume: 145, Issue:2

    Topics: Animals; Antigen-Presenting Cells; Aspartic Acid Endopeptidases; B-Lymphocytes; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Epitopes; H-2 Antigens; In Vitro Techniques; Leupeptins; Macrophages; Mice; Ovalbumin; Pepstatins; Peptide Fragments; T-Lymphocytes, Helper-Inducer

1990
Enhanced proliferation of murine T cell lines following interaction of Poly(Glu60, Phe40) (GPhe) and antigen-presenting accessory cells. III. Possible mechanisms responsible for activity of GPhe.
    Cellular immunology, 1990, Volume: 131, Issue:2

    Topics: Animals; Antibodies; Antigen-Presenting Cells; Cell Division; Cell Line; Cell Membrane; Culture Media; Epitopes; Interleukin-1; Leupeptins; Lymphocyte Activation; Mice; Phenylalanine; Polyglutamic Acid; T-Lymphocytes; Time Factors

1990
Soluble fibrin preparations inhibit the reaction of plasmin with alpha 2-macroglobulin. Comparison with alpha 2-antiplasmin and leupeptin.
    The Biochemical journal, 1991, Apr-01, Volume: 275 ( Pt 1)

    Topics: alpha-Macroglobulins; Chromogenic Compounds; Cyanogen Bromide; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Fibrinolysin; Humans; Kinetics; Leupeptins; Oligopeptides

1991
Cysteine proteinase inhibitors and bleomycin-sensitive and -resistant cells.
    Biochemical pharmacology, 1991, Jun-01, Volume: 41, Issue:11

    Topics: Bleomycin; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cysteine Proteinase Inhibitors; Drug Resistance; Drug Synergism; Head and Neck Neoplasms; Leucine; Leupeptins; Tumor Cells, Cultured

1991
Effects of inhibitors on proteinase activities in gels following isoelectric focussing.
    Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society, 1990, Volume: 1, Issue:4

    Topics: Amino Acid Sequence; Animals; Aprotinin; Endopeptidases; Isoelectric Focusing; Leupeptins; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Rats; Submandibular Gland; Trypsin Inhibitors

1990
The selective role of cathepsins B and D in the lysosomal degradation of endogenous and exogenous proteins.
    FEBS letters, 1991, Aug-05, Volume: 287, Issue:1-2

    Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Cathepsin B; Cathepsin D; Dipeptides; Fetuins; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Leupeptins; Liver; Lysosomes; Male; Pepstatins; Proteins; Rats; Rats, Inbred Strains; Thiocyanates

1991
Reversal of rapid axonal transport at a lesion: leupeptin inhibits reversed protein transport, but does not inhibit reversed organelle transport.
    Brain research, 1991, Jun-28, Volume: 552, Issue:2

    Topics: Animals; Axonal Transport; Axons; Leupeptins; Methionine; Nerve Crush; Nerve Tissue Proteins; Organelles; Reference Values; Sciatic Nerve; Spinal Cord; Sulfur Radioisotopes; Xenopus laevis

1991
Effect of neutral endopeptidase inhibition on substance-P-induced increase in short-circuit current of canine cultured tracheal epithelium.
    International archives of allergy and applied immunology, 1991, Volume: 95, Issue:2-3

    Topics: Amiloride; Animals; Anti-Bacterial Agents; Biological Transport, Active; Captopril; Cells, Cultured; Complement C1; Dogs; Dose-Response Relationship, Drug; Electric Conductivity; Female; Furosemide; Glycopeptides; In Vitro Techniques; Ion Channel Gating; Leucine; Leupeptins; Male; Membrane Potentials; Neprilysin; Substance P; Time Factors; Trachea

1991
Use of antibody/peptide constructs of direct antigenic peptides to T cells: evidence for T cell processing and presentation.
    Cellular immunology, 1992, Volume: 139, Issue:1

    Topics: Antigen-Antibody Complex; Antigen-Presenting Cells; Antigens, Bacterial; Chloroquine; Clone Cells; Dose-Response Relationship, Immunologic; Humans; In Vitro Techniques; Leupeptins; Lymphocyte Activation; Peptides; T-Lymphocytes; Tetanus Toxoid

1992
The ability and inability of ATP to stop aluminum from reducing the sodium efflux in unpoisoned barnacle muscle fibers.
    Biochimica et biophysica acta, 1992, Jan-10, Volume: 1103, Issue:1

    Topics: Adenosine Triphosphate; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Biological Transport; Chlorides; Drug Antagonism; Leupeptins; Magnesium Chloride; Myofibrils; Pepstatins; Sodium; Thoracica

1992
Dysfunction of nonadrenergic noncholinergic inhibitory system after antigen inhalation in actively sensitized cat airways.
    The American review of respiratory disease, 1992, Volume: 145, Issue:1

    Topics: Administration, Inhalation; Airway Resistance; Animals; Antigens; Ascaris; Bronchi; Cats; Electric Stimulation; Immunization; Leupeptins; Nervous System; Neural Inhibition; Respiratory Hypersensitivity; Serine Proteinase Inhibitors; Vasoactive Intestinal Peptide

1992
Leupeptin and ammonium chloride inhibit intrinsic factor mediated transcytosis of [57Co]cobalamin across polarized renal epithelial cells.
    Biochemical and biophysical research communications, 1992, Jan-31, Volume: 182, Issue:2

    Topics: Ammonium Chloride; Animals; Autoradiography; Biological Transport; Cells, Cultured; Chromatography, Gel; Cobalt Radioisotopes; Electrophoresis, Polyacrylamide Gel; Epithelium; Intrinsic Factor; Iodine Radioisotopes; Kidney; Leupeptins; Molecular Weight; Opossums; Rats; Vitamin B 12

1992
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
    Science (New York, N.Y.), 1992, Feb-07, Volume: 255, Issue:5045

    Topics: Ammonium Chloride; Amyloid; Amyloid beta-Protein Precursor; Base Sequence; Cell Line; Endopeptidases; Humans; Leupeptins; Lysosomes; Molecular Sequence Data; Mutagenesis; Peptide Fragments; Transfection

1992
Acid proteinases of the fore-gut in metamorphosing tadpoles of Rana catesbeiana.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1991, Volume: 99, Issue:3

    Topics: Animals; Chromatography, Agarose; Digestive System; Endopeptidases; Hydrogen-Ion Concentration; Larva; Leupeptins; Molecular Weight; Pepstatins; Rana catesbeiana

1991
Calcium-dependent and calcium-independent protease activities in skeletal muscle during sepsis.
    Circulatory shock, 1991, Volume: 35, Issue:2

    Topics: Animals; Bacteremia; Calcium; Calpain; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Escherichia coli Infections; Leupeptins; Male; Muscles; Rats; Rats, Inbred Strains

1991
Catalytic subunits of the multicatalytic proteinase.
    Biochemical Society transactions, 1991, Volume: 19, Issue:3

    Topics: Animals; Binding Sites; Cysteine Endopeptidases; Ethylmaleimide; Leupeptins; Liver; Macromolecular Substances; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Substrate Specificity; Trypsin

1991
Lysosomotropic agents induce morphological and functional changes in human muscle cells in vitro.
    European journal of basic and applied histochemistry, 1991, Volume: 35, Issue:4

    Topics: Cells, Cultured; Chloroquine; Histocytochemistry; Humans; Leupeptins; Lysosomes; Microscopy, Electron; Muscles; Propranolol

1991
Inhibitory effects of recombinant human cystatin C on human coronaviruses.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:11

    Topics: Antiviral Agents; Cathepsin B; Cells, Cultured; Coronaviridae; Cycloheximide; Cystatin C; Cystatins; Escherichia coli; Humans; Leupeptins; Papain; Recombinant Proteins; Virus Replication

1991
Atrial natriuretic factor inhibits ciliary motility in cultured rabbit tracheal epithelium.
    The American journal of physiology, 1991, Volume: 260, Issue:2 Pt 1

    Topics: Animals; Atrial Natriuretic Factor; Captopril; Cells, Cultured; Cilia; Enzyme Inhibitors; Epithelium; Glycopeptides; Indomethacin; Kinetics; Leucine; Leupeptins; Male; Masoprocol; Methylene Blue; Movement; Piroxicam; Purinones; Rabbits; Thiorphan; Trachea

1991
Intracellular catabolism of radiolabeled anti-CD3 antibodies by leukemic T cells.
    Cellular immunology, 1991, Oct-01, Volume: 137, Issue:1

    Topics: Ammonium Chloride; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Autoradiography; CD3 Complex; Endocytosis; Humans; In Vitro Techniques; Leukemia-Lymphoma, Adult T-Cell; Leupeptins; Molecular Weight; Monensin; Peptide Fragments; Receptors, Antigen, T-Cell; T-Lymphocytes; Tumor Cells, Cultured

1991
The N-glycan processing in HT-29 cells is a function of their state of enterocytic differentiation. Evidence for an atypical traffic associated with change in polypeptide stability in undifferentiated HT-29 cells.
    The Journal of biological chemistry, 1991, Nov-05, Volume: 266, Issue:31

    Topics: 1-Deoxynojirimycin; alpha-Mannosidase; Biological Transport; Cell Differentiation; Colon; Colonic Neoplasms; Glucosamine; Humans; In Vitro Techniques; Leupeptins; Mannosidases; Membrane Glycoproteins; Monensin; Polysaccharides; Protein Processing, Post-Translational; Tumor Cells, Cultured

1991
Inhibition of proteolysis protects hippocampal neurons from ischemia.
    Proceedings of the National Academy of Sciences of the United States of America, 1991, Aug-15, Volume: 88, Issue:16

    Topics: Animals; Calpain; Cerebral Ventricles; Electrophysiology; Endopeptidases; Evoked Potentials; Gerbillinae; Hippocampus; Hypoxia; Infusions, Parenteral; Ischemic Attack, Transient; Leupeptins; Neurons; Spectrin; Synapses

1991
Proteolytic processing of the insulin receptor beta subunit is associated with insulin-induced receptor down-regulation.
    The Journal of biological chemistry, 1991, Aug-25, Volume: 266, Issue:24

    Topics: Animals; Blotting, Western; Cells, Cultured; Chloroquine; Cycloheximide; Cysteine Endopeptidases; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Insulin; Insulin Antagonists; Leucine; Leupeptins; Mice; Peptide Fragments; Receptor, Insulin

1991
The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitors.
    Journal of immunology (Baltimore, Md. : 1950), 1991, Sep-15, Volume: 147, Issue:6

    Topics: Animals; Antigen-Presenting Cells; B-Lymphocytes; Hybridomas; In Vitro Techniques; Leupeptins; Mice; Ovalbumin; Peptides; Protease Inhibitors; Spleen; T-Lymphocytes

1991
Direct evidence for spatial and temporal regulation of transforming growth factor beta 1 expression during cutaneous wound healing.
    Journal of cellular physiology, 1991, Volume: 148, Issue:1

    Topics: Animals; Antibodies; Blister; Edetic Acid; Gene Expression Regulation; Humans; Immunohistochemistry; Leupeptins; Skin; Skin Physiological Phenomena; Swine; Transforming Growth Factor beta; Wound Healing

1991
Diastereotopic covalent binding of the natural inhibitor leupeptin to trypsin: detection of two interconverting hemiacetals by solution and solid-state NMR spectroscopy.
    Biochemistry, 1991, Oct-15, Volume: 30, Issue:41

    Topics: Binding Sites; Hydrogen-Ion Concentration; Leupeptins; Macromolecular Substances; Magnetic Resonance Spectroscopy; Serine Proteinase Inhibitors; Solutions; Trypsin

1991
Activation of intracellular calcium-activated neutral proteinase in erythrocytes and its inhibition by exogenously added inhibitors.
    Biochimica et biophysica acta, 1991, Sep-24, Volume: 1094, Issue:3

    Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blood Proteins; Calcimycin; Calcium; Calpain; Enzyme Activation; Erythrocytes; Female; In Vitro Techniques; Leucine; Leupeptins; Membrane Proteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Rabbits

1991
Effects of synthetic peptides and protease inhibitors on the interaction of a human ovarian cancer cell line (NIH:OVCAR-3) with a reconstituted basement membrane (Matrigel).
    Invasion & metastasis, 1991, Volume: 11, Issue:2

    Topics: Amides; Amino Acid Sequence; Aminocaproates; Antineoplastic Agents; Benzamidines; Biocompatible Materials; Cell Adhesion; Cell Line; Chemotaxis; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Female; Glycoproteins; Humans; In Vitro Techniques; Laminin; Leupeptins; Metalloendopeptidases; Molecular Sequence Data; Neoplasm Invasiveness; Oligopeptides; Ovarian Neoplasms; Pepstatins; Polyamines; Protease Inhibitors; Proteoglycans; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Tyrosine

1991
Effects of hypoxia and reoxygenation on the conversion of xanthine dehydrogenase to oxidase in Chinese hamster V79 cells.
    Free radical biology & medicine, 1991, Volume: 11, Issue:2

    Topics: Allopurinol; Animals; Calcium; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Glucose; Hypoxia; Leupeptins; Lipid Peroxidation; Verapamil; Xanthine Dehydrogenase; Xanthine Oxidase

1991
Studies on the antimalarial mode of action of quinoline-containing drugs: time-dependence and irreversibility of drug action, and interactions with compounds that alter the function of the parasite's food vacuole.
    Life sciences, 1991, Volume: 49, Issue:17

    Topics: Ammonium Chloride; Animals; Antimalarials; Drug Combinations; Drug Interactions; Hydrogen-Ion Concentration; Leupeptins; Plasmodium falciparum; Quinolines; Time Factors

1991
Natural killer cell activity of rhesus macaques against retrovirus-pulsed CD4+ target cells.
    AIDS research and human retroviruses, 1990, Volume: 6, Issue:7

    Topics: Animals; CD4 Antigens; CD4-Positive T-Lymphocytes; Cell Line; Cytotoxicity, Immunologic; Female; Humans; Interleukin-2; Killer Cells, Natural; Leupeptins; Macaca mulatta; Male; Retroviridae Infections; Simian Immunodeficiency Virus

1990
Multiple proteases regulate neurite outgrowth in NB2a/dl neuroblastoma cells.
    Journal of neurochemistry, 1991, Volume: 56, Issue:3

    Topics: Animals; Axons; Blood; Calpain; Endopeptidases; Hirudins; Leupeptins; Neuroblastoma; Osmolar Concentration; Protease Inhibitors; Thrombin; Tumor Cells, Cultured

1991
Protein phosphorylation substrates in normal and neoplastic squamous epithelia of the human upper aero-digestive tract.
    Life sciences, 1991, Volume: 48, Issue:10

    Topics: Aged; Autoradiography; Calcium; Carcinoma, Squamous Cell; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Humans; Leupeptins; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Proteins; Tissue Extracts

1991
Myofibrillar proteinase, cathepsin B, and protein breakdown rates in skeletal muscle from septic rats.
    Metabolism: clinical and experimental, 1991, Volume: 40, Issue:3

    Topics: Animals; Cathepsin B; Endopeptidases; Infections; Leupeptins; Male; Muscle Proteins; Muscles; Myofibrils; Rats; Rats, Inbred Strains; Reference Values

1991
Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome).
    Biochemistry, 1991, Mar-12, Volume: 30, Issue:10

    Topics: Amino Acid Sequence; Animals; Antipain; Cattle; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Erythrocytes; Humans; Insulin; Kinetics; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Oxidation-Reduction; Pentamidine; Proteasome Endopeptidase Complex

1991
Effects of calcium on protein turnover of incubated muscles from mdx mice.
    The American journal of physiology, 1991, Volume: 260, Issue:4 Pt 1

    Topics: Animals; Calcium; Cycloheximide; Kinetics; Leupeptins; Methylamines; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscles; Muscular Dystrophy, Animal; Proteins; Tyrosine

1991
Effect of calpain inhibitors on the invasion of human erythrocytes by the parasite Plasmodium falciparum.
    Biochimica et biophysica acta, 1991, Apr-15, Volume: 1096, Issue:3

    Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Erythrocytes; Humans; Leucine; Leupeptins; Oligopeptides; Pepstatins; Plasmodium falciparum

1991
Characterization of calcium-independent forms of protein kinase C-beta in phorbol ester-treated rabbit platelets.
    The Journal of biological chemistry, 1991, May-15, Volume: 266, Issue:14

    Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Blood Platelets; Blotting, Western; Calcium; Cell Compartmentation; Enzyme Activation; In Vitro Techniques; Leupeptins; Molecular Sequence Data; Molecular Weight; Peptides; Phosphorylation; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate

1991
Leupeptin causes an accumulation of lipofuscin-like substances in liver cells of young rats.
    Mechanisms of ageing and development, 1991, Volume: 57, Issue:3

    Topics: Aging; Animals; Ceroid; Histocytochemistry; Leupeptins; Lipofuscin; Liver; Male; Microscopy, Fluorescence; Rats; Rats, Inbred F344

1991
Two-stage autolysis of the catalytic subunit initiates activation of calpain I.
    Biochimica et biophysica acta, 1991, Jun-24, Volume: 1078, Issue:2

    Topics: Amino Acid Sequence; Animals; Calcium; Calcium-Binding Proteins; Calpain; Carbohydrate Sequence; Cattle; Enzyme Activation; Erythrocytes; Leupeptins; Molecular Sequence Data

1991
Study of thiol proteases of normal human skin fibroblasts.
    Cell biochemistry and function, 1991, Volume: 9, Issue:1

    Topics: Caseins; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Cell Fractionation; Cells, Cultured; Concanavalin A; Coumarins; Cysteine Endopeptidases; Dipeptides; Endopeptidases; Fibroblasts; Humans; Hydrogen-Ion Concentration; Hymecromone; Leupeptins; Lysosomes; Microsomes; Skin

1991
The effect of lysosomal inhibitors on protein degradation in cat hepatocyte monolayers.
    The International journal of biochemistry, 1991, Volume: 23, Issue:5-6

    Topics: Ammonium Chloride; Animals; Cats; Cells, Cultured; Cycloheximide; Insulin; Leucine; Leupeptins; Liver; Lysosomes; Proteins

1991
Calpain inhibitors block long-term potentiation.
    Brain research, 1990, Nov-26, Volume: 534, Issue:1-2

    Topics: Animals; Calpain; Glycoproteins; Hippocampus; In Vitro Techniques; Kinetics; Leupeptins; Neuronal Plasticity; Rats; Rats, Inbred Strains; Synapses

1990
Prevention of thromboxane B2-induced hepatocyte plasma membrane bleb formation by certain prostaglandins and a proteinase inhibitor.
    Biochimica et biophysica acta, 1990, Volume: 1022, Issue:3

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Calcimycin; Calcium; Cell Membrane; Epoprostenol; Leupeptins; Liver; Male; Oligopeptides; Prostaglandins E, Synthetic; Rats; Thromboxane B2

1990
Endocytosis and degradation of ovine prolactin by Nb2 lymphoma cells: characterization and effects of agents known to alter prolactin-induced mitogenesis.
    Endocrinology, 1990, Volume: 127, Issue:1

    Topics: Amiloride; Animals; Calcimycin; Cell Division; Cell Membrane; Chloroquine; Endocytosis; Kinetics; Leupeptins; Lymphoma; Methylamines; Mitosis; Monensin; Prolactin; Rats; Receptors, Prolactin; Sheep; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1990
Assembly and GPIIIa content of cytoskeletal core in platelets agglutinated with bovine von Willebrand factor.
    Blood, 1990, Oct-15, Volume: 76, Issue:8

    Topics: Actinin; Actins; Adenosine Diphosphate; Adult; Animals; Blood Platelets; Calpain; Cattle; Cytoskeleton; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Leupeptins; Microfilament Proteins; Molecular Weight; Myosins; Platelet Aggregation; Platelet Membrane Glycoproteins; von Willebrand Factor

1990
Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling.
    The Journal of biological chemistry, 1990, Aug-05, Volume: 265, Issue:22

    Topics: Animals; Aorta; Biological Transport; Cattle; Cells, Cultured; Chloroquine; Chondroitin Sulfate Proteoglycans; Cytochalasin B; Endothelium, Vascular; Female; Glycosaminoglycans; Heparan Sulfate Proteoglycans; Heparin; Heparin Lyase; Heparitin Sulfate; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Lipoprotein Lipase; Milk; Monensin; Polysaccharide-Lyases; Protein Binding; Proteoglycans; Swine

1990
Stabilization of rat cardiac sacroplasmic reticulum Ca2+ uptake activity and isolation of vesicles with improved calcium uptake activity.
    Molecular and cellular biochemistry, 1990, Dec-03, Volume: 99, Issue:1

    Topics: Animals; Calcium; Calcium-Transporting ATPases; Centrifugation, Density Gradient; Dithiothreitol; Dogs; Electrophoresis, Polyacrylamide Gel; Kinetics; Leupeptins; Male; Myocardium; Phenylmethylsulfonyl Fluoride; Potassium Chloride; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum; Sulfites

1990
Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slices.
    Brain research, 1990, Nov-05, Volume: 532, Issue:1-2

    Topics: Animals; Calpain; Cell Hypoxia; Glycoproteins; Hippocampus; In Vitro Techniques; Leupeptins; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission

1990
Endocytosis of liposomes containing lysosomal proteins increases intracellular protein degradation in growing L-132 cells.
    European journal of biochemistry, 1990, Feb-22, Volume: 188, Issue:1

    Topics: Cathepsins; Cells, Cultured; Chloroquine; Drug Carriers; Endocytosis; Ferritins; Humans; L Cells; Leupeptins; Liposomes; Lysosomes; Membrane Proteins; Microinjections; Microscopy, Electron; Peptide Hydrolases; Protein Biosynthesis; Proteins; Time Factors

1990
Regulation of total and myofibrillar protein breakdown in rat extensor digitorum longus and soleus muscle incubated flaccid or at resting length.
    The Biochemical journal, 1990, Apr-01, Volume: 267, Issue:1

    Topics: Animals; Insulin; Kinetics; Leupeptins; Male; Methylhistidines; Muscle Proteins; Muscles; Myofibrils; Rats; Rats, Inbred Strains; Tyrosine

1990
Trypsin-like hatching protease from mouse embryos: evidence for the presence in culture medium and its enzymatic properties.
    The Journal of experimental zoology, 1990, Volume: 254, Issue:1

    Topics: Animals; Blastocyst; Coumarins; Culture Media; Embryo, Mammalian; Leupeptins; Metalloendopeptidases; Mice; Mice, Inbred ICR; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Serine Endopeptidases; Substrate Specificity

1990
Cooperation of lysosomes and inner mitochondrial membrane in the degradation of carbamoyl phosphate synthetase and other proteins.
    Biochimica et biophysica acta, 1990, Jun-20, Volume: 1034, Issue:3

    Topics: Adenosine Triphosphate; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Enzyme Activation; Glutamates; Hydrogen-Ion Concentration; Intracellular Membranes; Leupeptins; Lysosomes; Mitochondria, Liver; Oligopeptides; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Rats; Substrate Specificity

1990
Phalloidin-induced accumulation of myosin in rat hepatocytes is caused by suppression of autolysosome formation.
    European journal of biochemistry, 1990, May-31, Volume: 190, Issue:1

    Topics: Acid Phosphatase; Actins; Animals; Cathepsins; Female; Fructose-Bisphosphate Aldolase; Immunoenzyme Techniques; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Microscopy, Electron; Myosins; Oligopeptides; Phalloidine; Pyruvate Kinase; Rats; Rats, Inbred Strains

1990
Another mechanism for the defect in type III collagen accumulation in Ehlers-Danlos syndrome type IV: increased intracellular degradation of the procollagen.
    Laboratory investigation; a journal of technical methods and pathology, 1990, Volume: 63, Issue:2

    Topics: Ammonium Chloride; Biological Transport; Blotting, Southern; Cells, Cultured; Collagen; Ehlers-Danlos Syndrome; Extracellular Space; Fluorescent Antibody Technique; Glycosylation; In Vitro Techniques; Leupeptins; Lysosomes; Peptide Fragments; Procollagen; Skin

1990
Phylogeny of immune recognition: antigen processing/presentation in channel catfish immune responses to hemocyanins.
    Cellular immunology, 1990, Oct-15, Volume: 130, Issue:2

    Topics: Ammonium Chloride; Animals; Antibody Formation; Antigen-Presenting Cells; Antigens; B-Lymphocytes; Chloroquine; Fixatives; Hemocyanins; Ictaluridae; In Vitro Techniques; Leupeptins; Lymphocyte Activation; Monensin; Monocytes; Phenylmethylsulfonyl Fluoride

1990
Protein breakdown in submandibular glands rendered hypertrophic by amputation of lower incisor teeth in rats.
    The Journal of Nihon University School of Dentistry, 1990, Volume: 32, Issue:3

    Topics: Aminocaproic Acid; Animals; Antipain; Hypertrophy; Incisor; Leupeptins; Male; Mandible; Pepstatins; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Rats; Rats, Inbred Strains; Salivary Proteins and Peptides; Submandibular Gland

1990
Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts.
    The Biochemical journal, 1990, Nov-15, Volume: 272, Issue:1

    Topics: Animals; Cathepsin L; Cathepsins; Cell Line; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Fibroblasts; Kinetics; Leupeptins; Methionine; Mice; Molecular Weight

1990
Factors influencing the binding of calpain I to human erythrocyte inside-out vesicles.
    Biochemistry international, 1990, Volume: 22, Issue:1

    Topics: Arginase; Calcium; Calcium-Binding Proteins; Calpain; Caseins; Erythrocyte Membrane; Humans; Immunoelectrophoresis; Immunoglobulins; Leupeptins; Models, Biological; Muramidase; Ovalbumin; Protease Inhibitors

1990
Proteolysis is a critical step in the physiological stop pathway: mechanisms involved in the blockade of axonal regeneration by mammalian astrocytes.
    Brain research, 1990, Apr-02, Volume: 512, Issue:2

    Topics: Animals; Astrocytes; Enzyme Inhibitors; Injections, Spinal; Leupeptins; Male; Microscopy, Electron; Nerve Endings; Nerve Regeneration; Nerve Tissue Proteins; Oligopeptides; Rats; Rats, Inbred Strains; Spinal Nerve Roots

1990
Uptake and intracellular processing of galactosyl-neoglycoalbumin by the isolated perfused rat liver.
    Biochemical Society transactions, 1990, Volume: 18, Issue:2

    Topics: 1-Naphthylisothiocyanate; Albumins; Animals; Asialoglycoprotein Receptor; Bile; Biological Transport, Active; In Vitro Techniques; Leupeptins; Liver; Perfusion; Rats; Receptors, Immunologic

1990
Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes.
    The Journal of cell biology, 1990, Volume: 111, Issue:3

    Topics: Animals; Cell Fractionation; Centrifugation, Density Gradient; Cytosol; Electricity; Female; Half-Life; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Phagocytosis; Rats; Rats, Inbred Strains; Vacuoles

1990
Stabilization of insulin receptor subunit structure by glutathione-insulin transhydrogenase.
    Biochimica et biophysica acta, 1986, Apr-22, Volume: 870, Issue:3

    Topics: Animals; Antipain; Aprotinin; Electrophoresis, Polyacrylamide Gel; Ethylmaleimide; Insulin; Isomerases; Leupeptins; Macromolecular Substances; Molecular Weight; Oxidoreductases; Protein Disulfide Reductase (Glutathione); Protein Disulfide-Isomerases; Rats; Receptor, Insulin

1986
Degradation of [125I]iodoglucagon by normal rat plasma in radioimmunoassay mixture containing aprotinin and its prevention by p-chloromercuriphenyl sulfonate and leupeptin.
    Endocrinology, 1986, Volume: 119, Issue:3

    Topics: 4-Chloromercuribenzenesulfonate; Animals; Aprotinin; Blood; Chromatography, Gel; Dose-Response Relationship, Drug; Glucagon; Immune Sera; Leupeptins; Male; Oligopeptides; Phenylmercury Compounds; Protease Inhibitors; Radioimmunoassay; Rats; Rats, Inbred Strains

1986
Antigen-Ia interaction and the proteolytic processing of antigen: the structure of the antigen determines its restriction to the A or E molecule of the major histocompatibility complex.
    European journal of immunology, 1986, Volume: 16, Issue:9

    Topics: Animals; Antigen-Presenting Cells; Antigens; Clone Cells; Epitopes; H-2 Antigens; Histocompatibility Antigens Class II; Leupeptins; Major Histocompatibility Complex; Mice; Mice, Inbred Strains; Muramidase; Peptide Hydrolases; T-Lymphocytes

1986
Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.
    The Journal of biological chemistry, 1986, Oct-05, Volume: 261, Issue:28

    Topics: Animals; Caenorhabditis elegans Proteins; Calcium; Carrier Proteins; Cell Line; Chromatography, Gel; Cytosol; Diglycerides; Female; Keratins; Leupeptins; Molecular Weight; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylserines; Pregnancy; Protein Kinase C; Rats; Receptors, Drug; Receptors, Immunologic; Skin; Tetradecanoylphorbol Acetate; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone

1986
Effect of protease inhibitors on skeletal muscle lysosomal enzyme activity and resting membrane potential.
    Experimental neurology, 1986, Volume: 94, Issue:3

    Topics: Acetylglucosaminidase; Animals; Aprotinin; Chloroquine; Leupeptins; Lysosomes; Male; Membrane Potentials; Muscle Denervation; Muscles; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Rats; Rats, Inbred Strains

1986
[Comparative studies of nafamostat mesilate and various serine protease inhibitors in vitro].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 88, Issue:6

    Topics: alpha-Macroglobulins; Aprotinin; Benzamidines; Complement Inactivator Proteins; Gabexate; Glycoproteins; Guanidines; Hemolysis; In Vitro Techniques; Leupeptins; Protease Inhibitors; Protein Binding

1986
Enzymatic regulation of calcium current in dialyzed and intact molluscan neurons.
    Journal de physiologie, 1986, Volume: 81, Issue:4

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Calmodulin-Binding Proteins; Egtazic Acid; Helix, Snails; In Vitro Techniques; Ion Channels; Leupeptins; Neurons; Phosphoprotein Phosphatases; Protein Kinases

1986
Perinatal leupeptin retards subsequent acquisition of a visual discrimination task in chicks.
    Behavioral and neural biology, 1987, Volume: 47, Issue:2

    Topics: Animals; Aprotinin; Chickens; Discrimination Learning; Glutamates; Glutamic Acid; Leupeptins; Oligopeptides; Visual Perception; Vocalization, Animal

1987
A G protein directly regulates mammalian cardiac calcium channels.
    Science (New York, N.Y.), 1987, Nov-27, Volume: 238, Issue:4831

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Heart; Ion Channels; Isoproterenol; Leupeptins; Membrane Potentials; Phosphorylation; Thionucleotides; Ventricular Function

1987
Potentiation of the cytotoxicity of peplomycin against Ehrlich ascites carcinoma by bleomycin hydrolase inhibitors.
    The Journal of antibiotics, 1987, Volume: 40, Issue:12

    Topics: Animals; Bleomycin; Carcinoma, Ehrlich Tumor; Cell Survival; Cysteine Endopeptidases; Drug Synergism; Female; Glycoside Hydrolases; Leucine; Leupeptins; Mice; Oligopeptides; Peplomycin

1987
Leupeptin-mediated alteration of renal phagolysosomes: similarity to hyaline droplet nephropathy of male rats exposed to unleaded gasoline.
    Toxicology letters, 1988, Volume: 41, Issue:3

    Topics: Alpha-Globulins; Animals; Gasoline; Kidney; Kidney Diseases; Leupeptins; Male; Oligopeptides; Petroleum; Phagosomes; Proteins; Rats; Rats, Inbred F344

1988
Enhancement of transformed cell growth in agar by serine protease inhibitors.
    Journal of cellular physiology, 1988, Volume: 136, Issue:1

    Topics: Antigens, Polyomavirus Transforming; Aprotinin; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Humans; Leupeptins; Serine Proteinase Inhibitors; Trypsin Inhibitor, Kunitz Soybean

1988
Calcium-dependent inactivation of the ATP-sensitive K+ channel of rat ventricular myocytes.
    Biochimica et biophysica acta, 1988, Aug-18, Volume: 943, Issue:2

    Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane; Electric Conductivity; Fluorides; Heart; Heart Ventricles; Ion Channels; Kinetics; Leupeptins; Potassium; Rats

1988
Regulation of Hermissenda K+ channels by cytoplasmic and membrane-associated C-kinase.
    Journal of neurochemistry, 1988, Volume: 51, Issue:3

    Topics: Animals; Calcium; Cell Membrane; Central Nervous System; Cytoplasm; Electric Conductivity; Ion Channels; Leupeptins; Models, Biological; Mollusca; Nerve Tissue Proteins; Phorbol Esters; Phosphorylation; Photoreceptor Cells; Potassium; Protein Kinase C; Trypsin

1988
Regulation of glycosphingolipid glycosyltransferase by low density lipoprotein receptors in cultured human proximal tubular cells.
    The Journal of biological chemistry, 1988, Sep-15, Volume: 263, Issue:26

    Topics: alpha-Fetoproteins; beta-Galactosidase; Cell Count; Cells, Cultured; Humans; Hyperlipoproteinemia Type II; Kidney Tubules, Proximal; Leupeptins; Lipoproteins, LDL; Methylation; Receptors, LDL; Time Factors

1988
Individual class II-restricted antigenic determinants of the same protein exhibit distinct kinetics of appearance and persistence on antigen-presenting cells.
    Journal of immunology (Baltimore, Md. : 1950), 1988, Oct-15, Volume: 141, Issue:8

    Topics: Animals; Antigen-Presenting Cells; B-Lymphocytes; Cell Line; Epitopes; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral; Histocompatibility Antigens Class II; Kinetics; Leupeptins; Mice; Mice, Inbred BALB C; T-Lymphocytes; Viral Proteins

1988
[Phorbol myristate acetate promotes entry of calcium in hypophysial cells GH3 B6 via potential dependent calcium channels].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1988, Volume: 182, Issue:1

    Topics: Animals; Barium; Calcium; Cell Line; Electrophysiology; Ion Channels; Leupeptins; Pituitary Gland; Rats; Tetradecanoylphorbol Acetate

1988
Inhibition of proteolysis blocks anterograde-retrograde conversion of axonally transported vesicles.
    Brain research, 1988, Sep-13, Volume: 460, Issue:1

    Topics: Animals; Axonal Transport; Axons; Leucine; Leupeptins; Male; Microscopy, Electron; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Reference Values; Sciatic Nerve

1988
Identification of proteases that process distinct epitopes on the same protein.
    Journal of immunology (Baltimore, Md. : 1950), 1989, Apr-01, Volume: 142, Issue:7

    Topics: Animals; Antigen-Presenting Cells; Antigens, Surface; Cathepsin B; Epitopes; Female; Histocompatibility Antigens Class II; Hydrolysis; Leupeptins; Male; Mice; Myoglobin; Peptide Hydrolases; Protease Inhibitors

1989
Characterization of the catalytic residues of the tobacco etch virus 49-kDa proteinase.
    Virology, 1989, Volume: 172, Issue:1

    Topics: Aprotinin; Binding Sites; DNA Mutational Analysis; Genes, Viral; Leupeptins; Papain; Peptide Hydrolases; Plant Viruses; Substrate Specificity; Viral Proteins; Zinc

1989
Characterization of proteolytic and collagenolytic enzymes from the larvae of Lucilia cuprina, the sheep blowfly.
    Australian journal of biological sciences, 1988, Volume: 41, Issue:2

    Topics: Animals; Aprotinin; Collagen; Diptera; Gelatin; Hydrogen-Ion Concentration; Isoelectric Point; Larva; Leupeptins; Microbial Collagenase; Molecular Weight; Peptide Hydrolases; Phenylmethylsulfonyl Fluoride; Protease Inhibitors

1988
Purification and characterization of a protease from Xenopus embryos.
    European journal of biochemistry, 1989, Dec-08, Volume: 186, Issue:1-2

    Topics: Animals; Antipain; Chromatography; Embryo, Nonmammalian; Enzyme Activation; Iodoacetates; Iodoacetic Acid; Leupeptins; Molecular Weight; Peptide Hydrolases; Polyribonucleotides; RNA; Substrate Specificity; Xenopus

1989
Effects of lovastatin and leupeptin on ceroidogenesis of vitamin E-deficient and -supplemented young rats.
    Advances in experimental medicine and biology, 1989, Volume: 266

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Ceroid; Cholesterol; Dolichols; Eating; Female; Kidney; Leupeptins; Liver; Lovastatin; Organ Size; Rats; Rats, Inbred Strains; Vitamin E; Vitamin E Deficiency

1989
Lipofuscin-like substances accumulate rapidly in brain, retina and internal organs with cysteine protease inhibition.
    Advances in experimental medicine and biology, 1989, Volume: 266

    Topics: Aging; Animals; Brain; Cysteine Proteinase Inhibitors; Dogs; Leupeptins; Lipofuscin; Lysosomes; Mice; Mice, Inbred C57BL; Microscopy, Electron; Rats; Rats, Inbred F344; Rats, Inbred Strains; Retina; Viscera

1989
Morphological, physiological and biochemical alterations in livers of rodents induced by protease inhibitors: a comparison with old livers.
    Advances in experimental medicine and biology, 1989, Volume: 266

    Topics: Aging; Animals; Biological Transport; Dolichols; Leucine; Leupeptins; Liver; Male; Mice; Mice, Inbred C57BL; Ouabain; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Inbred Strains; Sulfobromophthalein

1989
An epidermal growth factor-ricin A chain (EGF-RTA)-resistant mutant and an epidermal growth factor-Pseudomonas endotoxin (EGF-PE)-resistant mutant have distinct phenotypes.
    Journal of cellular physiology, 1989, Volume: 139, Issue:1

    Topics: Adenoviridae; ADP Ribose Transferases; Ammonium Chloride; Bacterial Toxins; Drug Resistance; Epidermal Growth Factor; Exotoxins; HeLa Cells; Humans; Immunotoxins; Leupeptins; Mutation; Phenotype; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Ricin; Virulence Factors

1989
Oleate-induced translocation of protein kinase C to hepatic microsomal membranes.
    Biochemical and biophysical research communications, 1989, May-15, Volume: 160, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Brain; Calcium; Fatty Acids; Intracellular Membranes; Isoenzymes; Isoquinolines; Leupeptins; Microsomes, Liver; Oleic Acid; Oleic Acids; Phorbol 12,13-Dibutyrate; Phosphatidate Phosphatase; Piperazines; Protein Kinase C; Rats; Spermine

1989
Quantitation of platelet fibrinogen and thrombospondin in Glanzmann's thrombasthenia by electroimmunoassay.
    Thrombosis research, 1989, Mar-15, Volume: 53, Issue:6

    Topics: Blood Platelet Disorders; Blood Platelets; Detergents; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Humans; Immunoblotting; Immunoelectrophoresis; Leupeptins; Membrane Glycoproteins; Octoxynol; Polyethylene Glycols; Thrombasthenia; Thrombospondins

1989
Action of endogenous proteases on the distribution of tyrosinase isozymes in Harding-Passey mouse melanoma.
    Cell biochemistry and function, 1989, Volume: 7, Issue:1

    Topics: Animals; Catechol Oxidase; Cathepsin D; Cytosol; Hydrolysis; Isoenzymes; Leupeptins; Melanocytes; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Pepstatins; Peptide Hydrolases; Phenylmethylsulfonyl Fluoride; Solubility

1989
Neuronal plasminogen activators: cell surface binding sites and involvement in neurite outgrowth.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1989, Volume: 9, Issue:12

    Topics: Amino Acid Chloromethyl Ketones; Animals; Axons; Benzoates; Binding Sites; Cell Membrane; Cell Survival; Dansyl Compounds; Leupeptins; Neurons; Plasminogen Activators; Sympathetic Nervous System; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator

1989
Intracellular degradation of unassembled asialoglycoprotein receptor subunits: a pre-Golgi, nonlysosomal endoproteolytic cleavage.
    The Journal of cell biology, 1989, Volume: 109, Issue:6 Pt 2

    Topics: Acetylglucosaminidase; Animals; Asialoglycoprotein Receptor; Cell Line; Chloroquine; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fluorescent Antibody Technique; Golgi Apparatus; Half-Life; Leupeptins; Lysosomes; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Microscopy, Fluorescence; Molecular Weight; Monensin; Receptors, Immunologic; Temperature

1989
Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes.
    The Journal of biological chemistry, 1989, Apr-15, Volume: 264, Issue:11

    Topics: Animals; Ankyrins; Binding Sites; Blood Proteins; Brain; Cell Compartmentation; Cell Membrane; Erythrocytes; Fluorescent Antibody Technique; In Vitro Techniques; Kidney; Leupeptins; Membrane Proteins; Microsomes; Molecular Weight; Peptide Hydrolases; Protein Binding; Sheep; Spectrin

1989
Ca2+-mediated activation of human erythrocyte membrane Ca2+-ATPase.
    Biochimica et biophysica acta, 1989, Jan-30, Volume: 978, Issue:2

    Topics: Calcium; Calcium-Transporting ATPases; Calmodulin; Calpain; Erythrocyte Membrane; Glycodeoxycholic Acid; Humans; Kinetics; Leupeptins

1989
The thiol proteinase inhibitors improve the abnormal rapid down-regulation of protein kinase C and the impaired natural killer cell activity in (Chediak-Higashi syndrome) beige mouse.
    Biochemical and biophysical research communications, 1989, Apr-28, Volume: 160, Issue:2

    Topics: Animals; Calpain; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Disease Models, Animal; Killer Cells, Natural; Killer Factors, Yeast; Leucine; Leupeptins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Protein Biosynthesis; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate

1989
Thrombin-induced platelet aggregation involves an indirect proteolytic cleavage of aggregin by calpain.
    Archives of biochemistry and biophysics, 1989, Volume: 271, Issue:2

    Topics: Adenosine; Adenosine Diphosphate; Affinity Labels; Antipain; Blood Platelets; Calpain; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Humans; Leupeptins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protease Inhibitors; Thrombin

1989
Degradation of 125I-glucagon, -pancreatic polypeptide and -insulin by acid saline extract of rat submaxillary gland and their protection by proteinase inhibitors.
    Endocrinologia japonica, 1989, Volume: 36, Issue:1

    Topics: 4-Chloromercuribenzenesulfonate; Animals; Chemical Precipitation; Chromatography, Gel; Ethylmaleimide; Glucagon; Hydrogen-Ion Concentration; Insulin; Iodine Radioisotopes; Leupeptins; Pancreatic Polypeptide; Protease Inhibitors; Rats; Rats, Inbred Strains; Sodium Chloride; Submandibular Gland; Trichloroacetic Acid

1989
Possibility of Bacteroides gingivalis hemagglutinin possessing protease activity revealed by inhibition studies.
    Microbiology and immunology, 1989, Volume: 33, Issue:1

    Topics: Bacteroides; Benzoylarginine Nitroanilide; Hemagglutination Inhibition Tests; Hemagglutinins; Leupeptins; Peptide Hydrolases; Protease Inhibitors

1989
Murine erythroleukemia cells possess an active ubiquitin- and ATP-dependent proteolytic pathway.
    Archives of biochemistry and biophysics, 1989, Volume: 272, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cell Differentiation; Lactoglobulins; Leukemia, Erythroblastic, Acute; Leupeptins; Ligases; Lysosomes; Mice; Peptide Hydrolases; Protease Inhibitors; Reticulocytes; Tumor Cells, Cultured; Ubiquitin-Protein Ligases; Ubiquitins

1989
A growth hormone-vesicular stomatitis virus G hybrid protein is rapidly degraded in lysosomes following transport to the cell surface.
    European journal of cell biology, 1989, Volume: 49, Issue:1

    Topics: Animals; Cells, Cultured; Chloroquine; Cricetinae; Endocytosis; Growth Hormone; Kidney; Leupeptins; Lysosomes; Membrane Proteins; Monensin; Vesicular stomatitis Indiana virus; Viral Proteins

1989
Evidence for two mechanisms of thrombin-induced platelet activation: one proteolytic, one receptor mediated.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 1989, Volume: 67, Issue:7

    Topics: Adenosine Diphosphate; Humans; In Vitro Techniques; Leupeptins; Phosphatidylinositols; Platelet Activating Factor; Platelet Activation; Receptors, Cell Surface; Receptors, Thrombin; Serotonin; Thrombin; Thromboxane A2; Trypsin

1989
Metalloproteinases are not involved in the phagocytosis of collagen fibrils by fibroblasts.
    Matrix (Stuttgart, Germany), 1989, Volume: 9, Issue:4

    Topics: Animals; Bone and Bones; Collagen; Culture Techniques; Cytochalasin B; Enzyme Inhibitors; Fibroblasts; Immune Sera; Immunoglobulin G; Kinetics; Leupeptins; Matrix Metalloproteinase 3; Metalloendopeptidases; Microbial Collagenase; Microscopy, Electron; Phagocytosis; Rabbits; Tissue Inhibitor of Metalloproteinases

1989
Properties of erythrocyte membrane binding and autolytic activation of calcium-activated neutral protease.
    The Journal of biological chemistry, 1989, Nov-05, Volume: 264, Issue:31

    Topics: Animals; Blood Proteins; Calcium; Calcium-Binding Proteins; Calpain; Caseins; Chickens; Egtazic Acid; Enzyme Activation; Erythrocyte Membrane; Immunoblotting; Kinetics; Leupeptins; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Rabbits; Vimentin

1989
Differential effects of leupeptin, monensin and colchicine on ligand degradation mediated by the two asialoglycoprotein receptor pathways in isolated rat hepatocytes.
    The Biochemical journal, 1989, Aug-15, Volume: 262, Issue:1

    Topics: Animals; Asialoglycoproteins; Cells, Cultured; Chloroquine; Colchicine; Dose-Response Relationship, Drug; Galactose; Leupeptins; Liver; Male; Monensin; Oligopeptides; Orosomucoid; Rats; Rats, Inbred Strains; Receptors, Cell Surface

1989
Cobalamin release from intrinsic factor and transfer to transcobalamin II within the rat enterocyte.
    The American journal of physiology, 1989, Volume: 257, Issue:5 Pt 1

    Topics: Administration, Oral; Animals; Animals, Suckling; Chloroquine; Gastric Mucosa; Immune Sera; Intestinal Mucosa; Intestines; Intrinsic Factor; Leupeptins; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Transcobalamins; Vitamin B 12

1989
Formation of N epsilon-(gamma-glutamyl)-lysine isodipeptide in Chinese-hamster ovary cells.
    The Biochemical journal, 1989, Nov-01, Volume: 263, Issue:3

    Topics: Animals; Cell Division; Cell Line; Chromatography, Ion Exchange; Cricetinae; Cricetulus; Dipeptides; gamma-Glutamylcyclotransferase; In Vitro Techniques; Leupeptins; Methylamines; Oligopeptides; Proteins; Transglutaminases

1989
Elucidation of cathepsin B-like activity associated with extracts of human myelin basic protein.
    FEBS letters, 1985, Jan-07, Volume: 179, Issue:2

    Topics: 4-Chloromercuribenzenesulfonate; Cathepsin B; Cathepsins; Dithioerythritol; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Leucine; Leupeptins; Myelin Basic Protein; Protease Inhibitors

1985
Effect of proteases on the beta-thromboglobulin radioimmunoassay.
    Life sciences, 1985, Feb-11, Volume: 36, Issue:6

    Topics: Animals; Aprotinin; Beta-Globulins; beta-Thromboglobulin; Histamine Release; Leupeptins; Mast Cells; p-Methoxy-N-methylphenethylamine; Pancreatic Elastase; Peptide Hydrolases; Platelet Factor 4; Radioimmunoassay; Rats; Rats, Inbred Strains

1985
Various proteinase inhibitors decrease prolactin and growth hormone release by anterior pituitary cells.
    Life sciences, 1985, Feb-11, Volume: 36, Issue:6

    Topics: Animals; Aprotinin; Cells, Cultured; Dose-Response Relationship, Drug; Female; Growth Hormone; Leupeptins; Oligopeptides; Phenylmethylsulfonyl Fluoride; Pituitary Gland, Anterior; Prolactin; Protease Inhibitors; Rats; Trypsin Inhibitor, Kunitz Soybean

1985
Regulation of ppp(A2'p)nA-dependent RNase levels during interferon treatment and cell differentiation.
    European journal of biochemistry, 1985, Feb-01, Volume: 146, Issue:3

    Topics: Affinity Labels; Animals; Cell Differentiation; Cell Line; Endoribonucleases; Interferons; Leupeptins; Mice; Neoplasms, Germ Cell and Embryonal; Protein Kinases; Ribonucleases

1985
Leupeptin as a tool for the detection of the sites of catabolism of rat high-density lipoprotein apolipoproteins A-I and E.
    Biochimica et biophysica acta, 1985, Mar-27, Volume: 834, Issue:1

    Topics: alpha-Fetoproteins; Animals; Apolipoprotein A-I; Apolipoproteins A; Apolipoproteins E; Asialoglycoproteins; Cathepsins; Fetuins; Kidney; Leupeptins; Lipoproteins, HDL; Liver; Lysosomes; Male; Oligopeptides; Rats; Rats, Inbred Strains; Serum Albumin; Time Factors

1985
Effects of lysosomal inhibitors on 125I-insulin and 125I-asialofetuin degradation by the isolated, perfused rat liver and isolated rat hepatocytes.
    Diabetes, 1985, Volume: 34, Issue:5

    Topics: alpha-Fetoproteins; Ammonium Chloride; Animals; Asialoglycoproteins; Chloroquine; Fetuins; In Vitro Techniques; Insulin; Iodine Radioisotopes; Leupeptins; Liver; Lysosomes; Male; Perfusion; Rats; Rats, Inbred Strains

1985
The protease inhibitor leupeptin interferes with the development of LTP in hippocampal slices.
    Brain research, 1989, Dec-29, Volume: 505, Issue:2

    Topics: Action Potentials; Animals; Hippocampus; In Vitro Techniques; Leupeptins; Male; Neuronal Plasticity; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains

1989
Secretory activity as a function of the development and maturation of ameloblasts.
    Connective tissue research, 1989, Volume: 22, Issue:1-4

    Topics: Ameloblasts; Animals; Cell Differentiation; Dental Enamel; Dental Enamel Proteins; In Vitro Techniques; Leupeptins; Lysosomes; Male; Rats; Rats, Inbred Strains

1989
Structural and functional aspects of HLA class II glycoproteins and the associated invariant chain.
    Cold Spring Harbor symposia on quantitative biology, 1989, Volume: 54 Pt 1

    Topics: Cell Line; Glycoproteins; HLA-D Antigens; Humans; Leupeptins; Molecular Structure; Molecular Weight; Monensin; Peptides; Protein Binding; Protein Conformation

1989
The influence of cathepsin B and leupeptin on potentially lethal damage repair in mammalian cells.
    International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:3

    Topics: Animals; Aspartic Acid Endopeptidases; Cathepsin B; Cell Line; Cell Survival; Cysteine Endopeptidases; DNA; DNA Repair; Endopeptidases; Leupeptins; Mutation; Oligopeptides; Serine Endopeptidases

1989
Activation of an insulin-stimulated S6 kinase in 3T3 L1 cell-free extracts by proteolysis.
    FEBS letters, 1989, May-08, Volume: 248, Issue:1-2

    Topics: Animals; Calcium; Cell-Free System; Chromatography; Enzyme Activation; Insulin; L Cells; Leupeptins; Mice; Peptide Hydrolases; Phosphates; Phosphorylation; Protein Kinases; Ribosomal Protein S6 Kinases; Trypsin

1989
Leupeptin alters the proteolytic processing of P126, the major parasitophorous vacuole antigen of Plasmodium falciparum.
    Molecular and biochemical parasitology, 1989, Mar-01, Volume: 33, Issue:2

    Topics: Animals; Antigens, Protozoan; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Humans; Hydrolysis; Immunosorbent Techniques; Leupeptins; Oligopeptides; Peptide Fragments; Plasmodium falciparum; Protease Inhibitors; Trypsin

1989
Differences in induction of lysosomal protease activity by protease inhibitors in B16 melanoma cell lines.
    The International journal of biochemistry, 1989, Volume: 21, Issue:2

    Topics: Acid Phosphatase; Animals; Cathepsin B; Enzyme Induction; Leucine; Leupeptins; Melanoma, Experimental; Mice; Oligopeptides; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Subcellular Fractions; Tumor Cells, Cultured

1989
Effects of inhibitors of membrane signal peptide peptidase on protein translocation into membrane vesicles.
    Archives of microbiology, 1989, Volume: 153, Issue:1

    Topics: Alkaline Phosphatase; Antipain; Bacterial Outer Membrane Proteins; Endopeptidases; Escherichia coli; Leupeptins; Membrane Proteins; Oligopeptides; Protease Inhibitors; Protein Processing, Post-Translational; Protein Sorting Signals; Serine Endopeptidases

1989
Impaired cholesterol esterification in cultured skin fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy.
    Biochemistry international, 1989, Volume: 18, Issue:6

    Topics: Autoradiography; Cell Fractionation; Cells, Cultured; Cholesterol Esters; Esterification; Fibroblasts; Humans; Leupeptins; Lysosomes; Monensin; Mucolipidoses; Niemann-Pick Diseases

1989
Degeneration of neuronal processes in rats induced by a protease inhibitor, leupeptin.
    Acta neuropathologica, 1989, Volume: 78, Issue:4

    Topics: Animals; Central Nervous System; Enzyme Inhibitors; Injections, Intraventricular; Leupeptins; Microscopy, Electron; Nerve Degeneration; Neurotoxins; Oligopeptides; Rats; Rats, Inbred Strains

1989
Cytotoxicities of two disulfide-bond-linked conjugates of methotrexate with monoclonal anti-MM46 antibody.
    Cancer immunology, immunotherapy : CII, 1989, Volume: 28, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Carcinoma, Ehrlich Tumor; Complement System Proteins; Cytotoxicity, Immunologic; Disulfides; Folic Acid Antagonists; Immunotoxins; Leupeptins; Methotrexate; Mice; Mice, Inbred C3H; Sulfhydryl Compounds; Thiamine Pyrophosphate

1989
Microinjections of leupeptin in the frontal cortex or dorsal hippocampus block spatial learning in the rat.
    Behavioral and neural biology, 1989, Volume: 52, Issue:2

    Topics: Animals; Arousal; Brain Mapping; Discrimination Learning; Frontal Lobe; Hippocampus; Injections; Leupeptins; Male; Memory; Mental Recall; Motor Activity; Oligopeptides; Orientation; Rats; Rats, Inbred Strains

1989
Epidermal growth factor-induced truncation of the epidermal growth factor receptor.
    The Journal of biological chemistry, 1989, Oct-25, Volume: 264, Issue:30

    Topics: Animals; Cells, Cultured; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Leupeptins; Methylamines; Mice; Mice, Inbred Strains; Molecular Weight; Thermodynamics

1989
The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7.
    Biochemical and biophysical research communications, 1987, Oct-14, Volume: 148, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytochalasin B; Diacylglycerol Kinase; Isoquinolines; Kinetics; Leupeptins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phosphotransferases; Piperazines; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rabbits; Superoxides; Thiazoles

1987
Aggregation-related association of lipid with the cytoskeleton of rabbit and human platelets prelabeled with [3H]palmitic acid. Similar effects of adenosine diphosphate- and thrombin-induced aggregation.
    The Journal of clinical investigation, 1988, Volume: 81, Issue:2

    Topics: Actin Cytoskeleton; Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Cyclic AMP; Cytoskeleton; Deoxyribonuclease I; Fibrinogen; Humans; In Vitro Techniques; Leupeptins; Lipid Metabolism; Microscopy, Electron; Palmitic Acid; Palmitic Acids; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Thrombin

1988
Stimulation of high-affinity GTPase by trypsin and trypsin-like proteinases in membranes of human platelets.
    The Biochemical journal, 1988, Feb-01, Volume: 249, Issue:3

    Topics: Blood Platelets; Cell Membrane; Chymotrypsin; Endopeptidases; Epinephrine; Ethylmaleimide; GTP Phosphohydrolases; Guanosine Triphosphate; Humans; In Vitro Techniques; Leupeptins; Phosphoric Monoester Hydrolases; Stimulation, Chemical; Thrombin; Trypsin

1988
Inhibition of thrombin-induced platelet activation by leupeptin. Implications for the participation of calpain in the initiation of platelet activation.
    The Journal of biological chemistry, 1988, Apr-15, Volume: 263, Issue:11

    Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Antipain; Calpain; Dose-Response Relationship, Drug; GTP-Binding Proteins; Humans; Leupeptins; Oligopeptides; Phosphatidic Acids; Phosphatidylinositols; Platelet Aggregation; Thrombin; Virulence Factors, Bordetella

1988
Cytocidal mechanism of TNF: effects of lysosomal enzyme and hydroxyl radical inhibitors on cytotoxicity.
    Immunopharmacology and immunotoxicology, 1988, Volume: 10, Issue:1

    Topics: Ammonium Chloride; Animals; Chloroquine; Cytotoxicity, Immunologic; Dimethyl Sulfoxide; Free Radicals; Hydroxides; Hydroxyl Radical; Leupeptins; Masoprocol; Methylamines; Mice; Muramidase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1988
Fluoride-dependent calcium-induced platelet procoagulant activity shows that calpain is involved in increased phospholipid transbilayer movement.
    Biochimica et biophysica acta, 1988, Jul-07, Volume: 942, Issue:1

    Topics: Blood Platelets; Calcium; Calpain; Fluorides; Humans; In Vitro Techniques; Leupeptins; Lipid Bilayers; Membrane Lipids; Membrane Proteins; Motion; Phosphatidylserines; Thromboplastin

1988
Evidence for two independent pathways of insulin-receptor internalization in hepatocytes and hepatoma cells.
    Diabetes, 1988, Volume: 37, Issue:6

    Topics: 2,4-Dinitrophenol; Animals; Biological Transport; Biotransformation; Carcinoma, Hepatocellular; Cells, Cultured; Chloroquine; Coated Pits, Cell-Membrane; Dinitrophenols; Humans; Insulin; Leupeptins; Liver; Liver Neoplasms; Monensin; Osmolar Concentration; Potassium; Rats; Receptor, Insulin; Tumor Cells, Cultured

1988
Synthesis of a new cell penetrating calpain inhibitor (calpeptin).
    Biochemical and biophysical research communications, 1988, Jun-30, Volume: 153, Issue:3

    Topics: Animals; Blood Platelets; Calcimycin; Calpain; Cell Membrane Permeability; Dipeptides; Leupeptins; Microfilament Proteins; Papain; Peptides; Swine

1988
Calcium-activated neutral proteases (calpains) are carbohydrate binding proteins.
    The Journal of biological chemistry, 1988, Aug-25, Volume: 263, Issue:24

    Topics: Calcium; Calcium-Binding Proteins; Calpain; Carbohydrate Metabolism; Chromatography; Disaccharides; Enzyme Activation; Ethylene Glycol; Ethylene Glycols; Leupeptins; Octoxynol; Polyethylene Glycols; Sepharose; Thiocyanates; Urea

1988
The effect of microinfusions of drugs into the accessory olfactory bulb on the olfactory block to pregnancy.
    Neuroscience, 1988, Volume: 25, Issue:3

    Topics: Animals; Anisomycin; Bicuculline; Dose-Response Relationship, Drug; Female; Leupeptins; Male; Mice; Mice, Inbred BALB C; Microinjections; Olfactory Bulb; Phentolamine; Pheromones; Pregnancy; Pregnancy, Animal; Receptors, Adrenergic, alpha

1988
Lesions of entorhinal cortex produce a calpain-mediated degradation of brain spectrin in dentate gyrus. I. Biochemical studies.
    Brain research, 1988, Sep-06, Volume: 459, Issue:2

    Topics: Animals; Calmodulin; Calpain; Cerebral Cortex; Enzyme Inhibitors; Hippocampus; Injections, Intraventricular; Leupeptins; Male; Molecular Weight; Rats; Rats, Inbred Strains; Spectrin

1988
Lesions of entorhinal cortex produce a calpain-mediated degradation of brain spectrin in dentate gyrus. II. Anatomical studies.
    Brain research, 1988, Sep-06, Volume: 459, Issue:2

    Topics: Animals; Calpain; Cerebral Cortex; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Leupeptins; Male; Nerve Degeneration; Rats; Rats, Inbred Strains; Spectrin; Time Factors

1988
Protease inhibitors suppress the in vitro and in vivo replication of rotavirus.
    The Journal of clinical investigation, 1988, Volume: 82, Issue:6

    Topics: Animals; Benzimidazoles; Cell Line; Humans; Leupeptins; Mice; Pentamidine; Protease Inhibitors; Rotavirus; Virus Replication

1988
Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain.
    Biochemical and biophysical research communications, 1988, Dec-30, Volume: 157, Issue:3

    Topics: Animals; Blotting, Western; Calcimycin; Calcium; Calpain; Cell Membrane Permeability; Cytoskeletal Proteins; Dipeptides; Erythrocyte Membrane; Hydrolysis; Leupeptins; Membrane Proteins; Molecular Weight; Peptide Hydrolases; Protease Inhibitors; Rats; Spectrin

1988
Ca2+-mediated catabolism of human erythrocyte band 3 protein.
    Biochimica et biophysica acta, 1988, Dec-08, Volume: 946, Issue:1

    Topics: Anion Exchange Protein 1, Erythrocyte; Calcium; Calpain; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Leupeptins; Molecular Weight

1988
The effects of cytotropic compounds on the resialylation of human asialotransferrin type 3 in the rat.
    Experimental cell research, 1985, Volume: 157, Issue:2

    Topics: Alkaloids; Animals; Asialoglycoproteins; Chloroquine; Colchicine; Female; Humans; Leupeptins; Liver; Lysine; Male; Microtubules; Paclitaxel; Protein Biosynthesis; Rats; Starvation; Transferrin; Vinblastine

1985
Insulin processing and action in adipocytes: evidence for generation of insulin-containing vesicles by leupeptin and monensin.
    FEBS letters, 1985, Mar-25, Volume: 182, Issue:2

    Topics: Acetyl-CoA Carboxylase; Adipose Tissue; Animals; Centrifugation, Density Gradient; Deoxyglucose; Enzyme Activation; Female; Furans; Insulin; Leupeptins; Microscopy, Electron; Monensin; Oligopeptides; Organoids; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains

1985
Inhibition of plant cell proteolytic activities that degrade tubulin.
    Cell biology international reports, 1985, Volume: 9, Issue:9

    Topics: Alkaloids; Electrophoresis, Polyacrylamide Gel; Immunosorbent Techniques; Leupeptins; Molecular Weight; Paclitaxel; Pepstatins; Plants; Protease Inhibitors; Tubulin

1985
Receptor-bound somatostatin and epidermal growth factor are processed differently in GH4C1 rat pituitary cells.
    The Journal of cell biology, 1986, Volume: 102, Issue:3

    Topics: Ammonium Chloride; Animals; Cell Compartmentation; Cell Line; Cell Membrane; Chloroquine; Cytosol; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Leupeptins; Lysosomes; Pituitary Neoplasms; Protein Binding; Rats; Receptors, Cell Surface; Receptors, Somatostatin; Somatostatin

1986
Targeting, internalization, and cytotoxicity of methotrexate-monoclonal anti-stage-specific embryonic antigen-1 antibody conjugates in cultured F-9 teratocarcinoma cells.
    Cancer research, 1986, Volume: 46, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Glycolipids; Immunoglobulin G; Leucovorin; Leupeptins; Lewis X Antigen; Lysosomes; Methotrexate; Mice; Mice, Inbred BALB C; Teratoma; Thiamine Pyrophosphate; Tritium

1986
Biosynthesis of intestinal microvillar proteins. Processing of N-linked carbohydrate is not required for surface expression.
    The Biochemical journal, 1986, Dec-15, Volume: 240, Issue:3

    Topics: Alkaloids; Aminopeptidases; Animals; Carbohydrate Metabolism; CD13 Antigens; Electrophoresis, Polyacrylamide Gel; Indolizines; Intestinal Mucosa; Leupeptins; Membrane Proteins; Microvilli; Organ Culture Techniques; Swine

1986
Platelet factor XIII is activated by calpain.
    Biochemical and biophysical research communications, 1987, Apr-14, Volume: 144, Issue:1

    Topics: Blood Platelets; Calcium; Calcium-Binding Proteins; Calpain; Enzyme Activation; Factor XIII; Humans; In Vitro Techniques; Leupeptins; Thrombin; Transglutaminases

1987
Spatial learning in the rat: impairment induced by the thiol-proteinase inhibitor, leupeptin, and an analysis of [3H]glutamate receptor binding in relation to learning.
    Behavioral and neural biology, 1987, Volume: 47, Issue:3

    Topics: Animals; Brain; Discrimination Learning; Glutamates; Glutamic Acid; Hippocampus; Injections, Intraventricular; Leupeptins; Male; Memory; Mental Recall; Neural Pathways; Oligopeptides; Orientation; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Space Perception; Synaptic Membranes

1987
The effect of analogues of chymostatin on lysosomal and non-lysosomal components of protein degradation in isolated hepatocytes.
    Biochimica et biophysica acta, 1987, Aug-13, Volume: 925, Issue:2

    Topics: Adenosine Triphosphate; Animals; Gluconeogenesis; In Vitro Techniques; Leupeptins; Liver; Lysosomes; Male; Oligopeptides; Protease Inhibitors; Rats; Structure-Activity Relationship; Tyrosine Transaminase

1987
Active and inactive forms of the transition-state analog protease inhibitor leupeptin: explanation of the observed slow binding of leupeptin to cathepsin B and papain.
    The Journal of biological chemistry, 1989, Jan-25, Volume: 264, Issue:3

    Topics: Algorithms; Arginine; Cathepsin B; Chromatography, High Pressure Liquid; Kinetics; Leupeptins; Magnetic Resonance Spectroscopy; Oligopeptides; Papain; Protease Inhibitors

1989
Comparative studies on insulin-like growth factor II and insulin processing by vascular endothelial cells.
    Diabetes, 1986, Volume: 35, Issue:10

    Topics: Animals; Aorta; Biological Transport; Cattle; Cells, Cultured; Chloroquine; Endothelium; Insulin; Insulin-Like Growth Factor II; Kinetics; Leupeptins; Models, Biological; Monensin; Receptor, Insulin; Receptors, Somatomedin; Somatomedins

1986
Evidence for two catabolic endoglycosidase activities in beta-mannosidase-deficient goat fibroblasts.
    Biochimica et biophysica acta, 1987, Apr-02, Volume: 928, Issue:1

    Topics: Animals; beta-Mannosidase; Biological Transport; Carbohydrate Sequence; Carrier Proteins; Cells, Cultured; Fibroblasts; Glycoproteins; Glycoside Hydrolases; Goats; Leupeptins; Lysosomes; Mannosidases; Receptor, IGF Type 2; Structure-Activity Relationship

1987
Antipain or leupeptin in combination with aspirin or indomethacin synergistically inhibit human platelet activation by thrombin and trypsin.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1987, Volume: 17A

    Topics: Antipain; Aspirin; Blood Platelets; Drug Synergism; Humans; In Vitro Techniques; Indomethacin; Leupeptins; Oligopeptides; Thrombin; Trypsin

1987
Membrane glycoproteins are involved in the differentiation of the BC3H1 muscle cell line.
    Experimental cell research, 1987, Volume: 173, Issue:1

    Topics: 1-Deoxynojirimycin; Acetylglucosamine; Alkaloids; Animals; Cell Differentiation; Cell Line; Creatine Kinase; Deoxy Sugars; Deoxyglucose; Enzyme Induction; Glucosamine; Glycoproteins; Indolizines; Leupeptins; Membrane Glycoproteins; Membrane Proteins; Mice; Muscles; Oligosaccharides; Swainsonine; Tunicamycin

1987
Analysis of proteolytic processing during specific antigen presentation.
    Cellular immunology, 1987, Volume: 110, Issue:2

    Topics: Animals; Antigen-Presenting Cells; Antigens; B-Lymphocytes; Cells, Cultured; Chloroquine; Haptens; Leupeptins; Lymphocyte Cooperation; Mice; Peptide Hydrolases; Receptors, Antigen, T-Cell; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Tosylphenylalanyl Chloromethyl Ketone; Trinitrobenzenes

1987
Intracellular processing of epidermal growth factor and its effect on ligand-receptor interactions.
    The Journal of biological chemistry, 1985, May-10, Volume: 260, Issue:9

    Topics: Animals; Cathepsin B; Cathepsins; Cell Line; Cold Temperature; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Hydrogen-Ion Concentration; Leupeptins; Methylamines; Mice; Models, Biological; Monensin; Receptors, Cell Surface

1985
Leupeptin, a protease inhibitor, blocks insemination-induced flight muscle histolysis in the fire ant Solenopsis.
    Tissue & cell, 1985, Volume: 17, Issue:1

    Topics: Animals; Ants; Atrophy; Calpain; Cytoskeleton; Endopeptidases; Female; Insemination; Leupeptins; Muscle Proteins; Muscles; Oligopeptides; Protease Inhibitors; Wings, Animal

1985
A human platelet angiotensin I-processing system. Identification of components and inhibition of angiotensin-converting enzyme by product.
    The Journal of biological chemistry, 1985, Jul-05, Volume: 260, Issue:13

    Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Blood Platelets; Chromatography, Gel; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Iodoacetamide; Leupeptins; Lung; Mersalyl; Molecular Weight; Rabbits

1985
Inhibition of fibrinogen receptor expression and serotonin release by leupeptin and antipain.
    The Journal of biological chemistry, 1985, Sep-05, Volume: 260, Issue:19

    Topics: Antipain; Binding, Competitive; Blood Platelets; Fibrinogen; Humans; Kinetics; Leupeptins; Oligopeptides; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Serotonin; Thrombin

1985
Activation of the PCSM-protein phosphatase by a Ca2+-dependent protease.
    FEBS letters, 1985, Nov-18, Volume: 192, Issue:2

    Topics: Animals; Calpain; Egtazic Acid; Enzyme Activation; Kinetics; Leupeptins; Muscles; Phosphoprotein Phosphatases; Rabbits

1985
Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.
    The Journal of cell biology, 1986, Volume: 102, Issue:1

    Topics: Animals; Cell Compartmentation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Immunoenzyme Techniques; Leupeptins; Liver; Lysosomes; Molecular Weight; Phosphorylation; Protein Kinases; Rats; Receptors, Cell Surface; Temperature

1986
Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor.
    The Journal of cell biology, 1986, Volume: 102, Issue:3

    Topics: Antibodies, Monoclonal; Binding Sites, Antibody; Cell Line; Chloroquine; Endocytosis; Half-Life; Humans; Iron; Leukemia, Erythroblastic, Acute; Leupeptins; Receptors, Cell Surface; Receptors, Transferrin

1986
Phosphorylation of bovine cardiac calcium-activated neutral protease by protein kinase-C.
    Biochemical and biophysical research communications, 1986, May-29, Volume: 137, Issue:1

    Topics: Animals; Calpain; Cattle; Enzyme Activation; Leupeptins; Macromolecular Substances; Molecular Weight; Myocardium; Phosphorylation; Phosphothreonine; Protein Kinase C

1986
Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring proteinase.
    The Journal of biological chemistry, 1986, Jun-25, Volume: 261, Issue:18

    Topics: Calpain; Cytochalasin B; Endopeptidases; Exocytosis; Humans; Hydrogen Peroxide; Leupeptins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Retinaldehyde; Serine Endopeptidases; Tetradecanoylphorbol Acetate; Trifluoperazine

1986
Cleavage site of calcium-dependent protease in human platelet membrane glycoprotein Ib.
    Thrombosis research, 1986, Jul-01, Volume: 43, Issue:1

    Topics: Animals; Calcimycin; Calcium; Calpain; Chickens; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Humans; Isoelectric Point; Leucine; Leupeptins; Membrane Proteins; Molecular Weight; Phenotype; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins

1986
Limited proteolysis of the erythrocyte membrane skeleton by calcium-dependent proteinases.
    Biochimica et biophysica acta, 1986, Jul-16, Volume: 882, Issue:3

    Topics: Anion Exchange Protein 1, Erythrocyte; Blood Proteins; Calcimycin; Calpain; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Humans; Leupeptins; Membrane Proteins; Mersalyl; Neuropeptides; Spectrin

1986
Effect of low calcium and protease inhibitors on synapse elimination during postnatal development in the rat soleus muscle.
    Brain research, 1986, Volume: 393, Issue:1

    Topics: Animals; Animals, Newborn; Calcium; Calpain; Egtazic Acid; Leupeptins; Mersalyl; Muscle Development; Neuromuscular Junction; Rats; Rats, Inbred Strains

1986
Four Ca2+-dependent proteinase activities isolated from crustacean muscle differ in size, net charge, and sensitivity to Ca2+ and inhibitors.
    The Journal of biological chemistry, 1986, Jul-25, Volume: 261, Issue:21

    Topics: Animals; Calcium; Calcium Channel Blockers; Calpain; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Iodoacetamide; Leupeptins; Molecular Weight; Muscles; Nephropidae; Pepstatins; Phenylmethylsulfonyl Fluoride

1986
Calcium-induced degeneration of the cytoskeleton in monkey and human peripheral nerves.
    Journal of hand surgery (Edinburgh, Scotland), 1986, Volume: 11, Issue:3

    Topics: Animals; Calcium; Calpain; Cebus; Culture Media; Cytoskeleton; Humans; Intermediate Filaments; Leupeptins; Microtubules; Nerve Degeneration; Peripheral Nerves; Wallerian Degeneration

1986
Targeting of neoglycoprotein-drug conjugates to cultured human embryonal carcinoma cells.
    Journal of cancer research and clinical oncology, 1987, Volume: 113, Issue:2

    Topics: Antineoplastic Agents; Cell Line; Cell Survival; Cisplatin; Etoposide; Glycoproteins; Humans; Lectins; Leupeptins; Methotrexate; Pharmaceutical Vehicles; Receptors, Cell Surface; Teratoma

1987
Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:7

    Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Brain; Carcinoma, Hepatocellular; Cattle; Cell Line; Endopeptidases; Fibroblast Growth Factors; Humans; Leupeptins; Liver Neoplasms; Molecular Weight; Protease Inhibitors

1987
Sendai-viral HN and F glycoproteins as probes of plasma-membrane protein catabolism in HTC cells. Studies with fusogenic reconstituted Sendai-viral envelopes.
    The Biochemical journal, 1987, Feb-01, Volume: 241, Issue:3

    Topics: Ammonium Chloride; Animals; Azides; Cell Line; Deoxyglucose; DNA, Viral; Hemagglutinins, Viral; HN Protein; Leupeptins; Liver Neoplasms, Experimental; Membrane Fusion; Membrane Proteins; Parainfluenza Virus 1, Human; Sodium Azide; Viral Envelope Proteins; Viral Fusion Proteins

1987
Protein damage and degradation by oxygen radicals. I. general aspects.
    The Journal of biological chemistry, 1987, Jul-15, Volume: 262, Issue:20

    Topics: Adenosine Triphosphate; Free Radicals; Hydroxides; Hydroxyl Radical; Leupeptins; Proteins; Superoxides

1987
Effects of low calcium and inhibition of calcium-activated neutral protease (CANP) on mature nerve terminal structure in the rat sternocostalis muscle.
    Brain research, 1987, Volume: 430, Issue:2

    Topics: Animals; Calcium; Calpain; Egtazic Acid; Leupeptins; Motor Neurons; Neuromuscular Junction; Neuronal Plasticity; Rats; Rats, Inbred Strains

1987
Regulation of the breakdown rates of biotin-containing proteins in Swiss 3T3-L1 cells.
    The Biochemical journal, 1988, May-01, Volume: 251, Issue:3

    Topics: Adenine; Biotin; Cell Line; Electrophoresis, Polyacrylamide Gel; Insulin; Leucine; Leupeptins; Proteins

1988
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
    The Journal of clinical investigation, 1988, Volume: 82, Issue:5

    Topics: Animals; Cysteine Endopeptidases; Hemoglobins; Leucine; Leupeptins; Malaria; Microscopy, Electron; Molecular Weight; Plasmodium falciparum; Protease Inhibitors

1988
Evidence for the role of proteinases in uremic catabolism.
    Advances in experimental medicine and biology, 1988, Volume: 240

    Topics: Acute Disease; Animals; Blood Chemical Analysis; Endopeptidases; Hydrolysis; Leupeptins; Male; Methylhistidines; Muscle Proteins; Nephrectomy; Protease Inhibitors; Rats; Rats, Inbred Strains; Uremia

1988
Ultrastructural study of the effect of calcium ionophore, A23187, on rat muscle.
    Acta neuropathologica, 1986, Volume: 69, Issue:3-4

    Topics: Animals; Calcimycin; Calcium; Cell Membrane; Creatine Kinase; Female; Freeze Fracturing; Leupeptins; Microscopy, Electron; Muscles; Muscular Dystrophies; Rats; Rats, Inbred Strains

1986
Involvement of thiol proteases in galactosialidosis.
    Clinica chimica acta; international journal of clinical chemistry, 1986, Mar-16, Volume: 155, Issue:2

    Topics: beta-Galactosidase; Cathepsin B; Cathepsin H; Cathepsins; Cells, Cultured; Coumarins; Cysteine Endopeptidases; Diazomethane; Dipeptides; Endopeptidases; Fibroblasts; Galactosidases; Humans; Leucine; Leupeptins; Neuraminidase; Protease Inhibitors

1986
Immunoelectron microscopical localization of lysosomal beta-galactosidase and its precursor forms in normal and mutant human fibroblasts.
    European journal of cell biology, 1986, Volume: 40, Issue:1

    Topics: Antibodies; Antibodies, Monoclonal; beta-Galactosidase; Fibroblasts; G(M1) Ganglioside; Galactosidases; Gangliosidoses; Histocytochemistry; Humans; Immunochemistry; Leupeptins; Lysosomes; Metabolism, Inborn Errors; Microscopy, Electron; Neuraminidase; Subcellular Fractions

1986
Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis.
    Cancer research, 1986, Volume: 46, Issue:8

    Topics: Animals; Cathepsin B; Cathepsins; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Endopeptidases; Female; Fibrinolysis; Leucine; Leupeptins; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Peptide Hydrolases; Plasminogen Activators; Plasminogen Inactivators; Protease Inhibitors; Serine Endopeptidases; Thrombin; Thrombosis

1986
The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism.
    The Biochemical journal, 1986, Aug-01, Volume: 237, Issue:3

    Topics: Animals; Calcimycin; Calcium; In Vitro Techniques; Leupeptins; Lysosomes; Male; Methylamines; Muscle Contraction; Muscle Proteins; Muscles; Protease Inhibitors; Rats; Rats, Inbred Strains

1986
Evidence against a possible involvement of the serine, and thiol proteases in the exocytotic mechanism of catecholamine secretion in cultured bovine adrenal medullary cells.
    Biochemistry international, 1986, Volume: 13, Issue:5

    Topics: Adrenal Medulla; Animals; Calcimycin; Carbachol; Catecholamines; Cattle; Cells, Cultured; Cysteine Endopeptidases; Endopeptidases; Exocytosis; Kinetics; Leupeptins; Oligopeptides; Potassium; Serine Endopeptidases

1986
Suppression of neurofilament degradation by protease inhibitors in experimental spinal cord injury.
    Brain research, 1987, Mar-17, Volume: 406, Issue:1-2

    Topics: Animals; Electrophoresis, Polyacrylamide Gel; Intermediate Filament Proteins; Leucine; Leupeptins; Male; Nerve Tissue Proteins; Neurofilament Proteins; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Cord Injuries

1987
Partial purification and characterization of cysteine proteinases in eccrine sweat.
    The American journal of physiology, 1987, Volume: 252, Issue:6 Pt 2

    Topics: Benzoylarginine-2-Naphthylamide; Chromatography, Affinity; Chromatography, Gel; Cysteine Endopeptidases; Dithiothreitol; Eccrine Glands; Edetic Acid; Endopeptidases; Hydrogen-Ion Concentration; Isoelectric Focusing; Isoenzymes; Leucine; Leupeptins; Molecular Weight; Sweat; Sweat Glands

1987
Biosynthesis and maturation of lactase-phlorizin hydrolase in the human small intestinal epithelial cells.
    The Biochemical journal, 1987, Jan-15, Volume: 241, Issue:2

    Topics: Antibodies, Monoclonal; beta-Galactosidase; Chemical Precipitation; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; Epithelium; Galactosidases; Glucosidases; Humans; Intestine, Small; Isoenzymes; Lactase-Phlorizin Hydrolase; Leupeptins; Monensin; Multienzyme Complexes; Protein Biosynthesis; Tunicamycin

1987
A possible role for dephosphorylation in glucocorticoid receptor transformation.
    Journal of steroid biochemistry, 1987, Volume: 26, Issue:6

    Topics: Alkaline Phosphatase; Animals; Cell Line; Cytosol; Dexamethasone; Edetic Acid; Leupeptins; Mice; Phosphorylation; Pituitary Neoplasms; Protease Inhibitors; Receptors, Glucocorticoid; Sodium Fluoride

1987
Import of rat liver mitochondrial transhydrogenase.
    The Biochemical journal, 1988, Jun-15, Volume: 252, Issue:3

    Topics: Animals; Biological Transport; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; In Vitro Techniques; Leupeptins; Liver; Mitochondria, Liver; NADH, NADPH Oxidoreductases; NADP Transhydrogenases; Phenanthrolines; Rats; Rhodamines

1988
The presence of a reduced amount of 32-kd "protective" protein is a distinct biochemical finding in late infantile galactosialidosis.
    Human genetics, 1988, Volume: 80, Issue:3

    Topics: beta-Galactosidase; Carbohydrate Metabolism, Inborn Errors; Cells, Cultured; Fibroblasts; Galactosidases; Humans; Infant; Leupeptins; Molecular Weight; Neuraminidase; Proteins

1988
Inhibition of early but not late proteolytic processing events leads to the missorting and oversecretion of precursor forms of lysosomal enzymes in Dictyostelium discoideum.
    The Journal of cell biology, 1988, Volume: 107, Issue:6 Pt 1

    Topics: alpha-Mannosidase; Antipain; beta-Glucosidase; Biological Transport; Cell Compartmentation; Cysteine Proteinase Inhibitors; Dictyostelium; Golgi Apparatus; Hexosaminidases; Leupeptins; Lysosomes; Mannosidases; Molecular Weight; Protein Processing, Post-Translational; Time Factors

1988
Reduction of muscle protein degradation by leupeptin in acutely uremic rats.
    Mineral and electrolyte metabolism, 1988, Volume: 14, Issue:5

    Topics: Acute Disease; Animals; Leupeptins; Male; Methylhistidines; Muscle Proteins; Muscles; Nephrectomy; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Urea; Uremia

1988
Subcellular distribution of protein kinase C in rat adrenal glomerulosa cells.
    Biochemical and biophysical research communications, 1988, Oct-31, Volume: 156, Issue:2

    Topics: Angiotensin II; Animals; Calcium; Cytosol; Leupeptins; Phenylmethylsulfonyl Fluoride; Phospholipids; Protein Kinase C; Rats; Rats, Inbred Strains; Subcellular Fractions; Tetradecanoylphorbol Acetate; Zona Glomerulosa

1988
Distribution of protein disulfide isomerase in rat hepatocytes.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1988, Volume: 36, Issue:12

    Topics: Animals; Cell Membrane; Endoplasmic Reticulum; Gold; Immunoblotting; Immunohistochemistry; Isomerases; Leupeptins; Liver; Lysosomes; Male; Microscopy, Electron; Microsomes, Liver; Nuclear Envelope; Protein Disulfide-Isomerases; Rats; Rats, Inbred Strains; Staphylococcal Protein A

1988
Ferritin iron kinetics and protein turnover in K562 cells.
    The Journal of biological chemistry, 1988, Dec-15, Volume: 263, Issue:35

    Topics: Animals; Cell Line; Deferoxamine; Electrophoresis, Polyacrylamide Gel; Ferritins; Iron; Kinetics; Leupeptins; Pentetic Acid; Proteins

1988
Degradation of aspartate aminotransferase in rat liver lysosomes.
    Biochemical and biophysical research communications, 1988, Dec-15, Volume: 157, Issue:2

    Topics: Animals; Aspartate Aminotransferases; Blotting, Western; Isoenzymes; Leupeptins; Liver; Lysosomes; Molecular Weight; Rats

1988
Influence of leupeptin on protein and amino-acid metabolism in septic rats.
    Biological chemistry Hoppe-Seyler, 1988, Volume: 369 Suppl

    Topics: Amino Acids; Animals; Bacterial Infections; Body Weight; Eating; Leupeptins; Liver; Muscles; Oligopeptides; Proteins; Rats; Rats, Inbred Strains; Tyrosine

1988
Increased mortality in septic rats after leupeptin application.
    Advances in experimental medicine and biology, 1988, Volume: 240

    Topics: Animals; Bacterial Infections; Body Weight; Creatinine; Leupeptins; Liver; Male; Muscles; Oligopeptides; Rats; Rats, Inbred Strains; Tyrosine

1988
Inhibition of EGF processing in responsive and nonresponsive human fibroblasts.
    Journal of cellular physiology, 1988, Volume: 135, Issue:1

    Topics: Animals; Cells, Cultured; Chloroquine; Epidermal Growth Factor; Humans; Iodine Radioisotopes; Kinetics; Leupeptins; Lung; Male; Mice; Protein Processing, Post-Translational; Skin

1988
Regulation of the production of a prolactin-like protein (MRP/PLF) in 3T3 cells and in the mouse placenta.
    Molecular and cellular endocrinology, 1988, Volume: 56, Issue:3

    Topics: Ammonium Chloride; Animals; Antipain; Cell Line; Epidermal Growth Factor; Fibroblast Growth Factors; Glycoproteins; Glycosylation; Intercellular Signaling Peptides and Proteins; Kinetics; Leupeptins; Mice; Monensin; Placenta; Prolactin; RNA, Messenger

1988
Selective inhibition of antigen presentation to cloned T cells by protease inhibitors.
    Journal of immunology (Baltimore, Md. : 1950), 1988, Nov-15, Volume: 141, Issue:10

    Topics: Animals; Antigen-Presenting Cells; Antipain; Clone Cells; Histocompatibility Antigens Class II; Immunosuppressive Agents; Leupeptins; Metalloendopeptidases; Mice; Oligopeptides; Protease Inhibitors; T-Lymphocytes

1988
Processing requirements for T cell activation by Mycoplasma arthritidis-derived mitogen.
    European journal of immunology, 1988, Volume: 18, Issue:12

    Topics: Ammonium Chloride; Antigen-Presenting Cells; Chloroquine; Formaldehyde; Leupeptins; Lymphocyte Activation; Lysosomes; Macrophages; Mitogens; Monensin; Mycoplasma; Polymers; T-Lymphocytes

1988
Thrombin-like inhibitory action of trypsin and trypsin-like proteases on human platelet adenylate cyclase.
    European journal of biochemistry, 1988, Feb-15, Volume: 172, Issue:1

    Topics: Acrosin; Adenylyl Cyclase Inhibitors; Animals; Blood Platelets; Cattle; Epinephrine; Guanosine Triphosphate; Humans; Leupeptins; Male; Peptide Hydrolases; Spermatozoa; Thrombin; Trypsin

1988
Role for intracellular proteases in the processing and transport of class II HLA antigens.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:11

    Topics: Biological Transport; Chloroquine; HLA-D Antigens; Humans; Leupeptins; Molecular Weight; Monensin; Peptide Hydrolases; Protein Processing, Post-Translational

1988
Inhibitory effect of a protease inhibitor, leupeptin, on the development of influenza pneumonia, mediated by concomitant bacteria.
    The Journal of general virology, 1987, Volume: 68 ( Pt 7)

    Topics: Animals; Endopeptidases; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral; Influenza A virus; Leupeptins; Metalloendopeptidases; Mice; Oligopeptides; Orthomyxoviridae Infections; Pneumonia, Staphylococcal; Protease Inhibitors; Protein Processing, Post-Translational; Staphylococcus aureus; Virus Replication

1987
Pharmacological protection against the toxicity of N-methyl-D-aspartate in immature rat cerebellar slices.
    Neuropharmacology, 1987, Volume: 26, Issue:12

    Topics: Animals; Aspartic Acid; Aspirin; Calcium Channel Blockers; Cerebellum; Female; In Vitro Techniques; Indomethacin; Kynurenic Acid; Leupeptins; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Taurine

1987
Evidence that cathepsin B contributes to skeletal muscle protein breakdown during sepsis.
    Archives of surgery (Chicago, Ill. : 1960), 1988, Volume: 123, Issue:2

    Topics: Animals; Bacterial Infections; Cathepsin B; Leupeptins; Male; Muscle Proteins; Muscles; Rats; Rats, Inbred Strains

1988
Degradation of the precursor of mitochondrial aspartate aminotransferase in chicken embryo fibroblasts.
    The Journal of biological chemistry, 1988, Mar-25, Volume: 263, Issue:9

    Topics: Adenosine Triphosphate; Animals; Antipain; Aspartate Aminotransferases; Chick Embryo; Cytosol; Enzyme Precursors; Fibroblasts; Half-Life; Leupeptins; Methylamines; Mitochondria; Monensin

1988
Degradation of endocytosed dermatan sulfate proteoglycan in human fibroblasts.
    The Journal of biological chemistry, 1988, Apr-25, Volume: 263, Issue:12

    Topics: Ammonium Chloride; Biological Transport; Cells, Cultured; Chondroitin; Chondroitin Sulfate Proteoglycans; Cycloheximide; Dermatan Sulfate; Diazomethane; Endocytosis; Fibroblasts; Half-Life; Humans; Kinetics; Leucine; Leupeptins; Lysosomes; Molecular Weight; Protease Inhibitors; Proteoglycans; Sulfates

1988
Effects of indomethacin and leupeptin on muscle cathepsin B activity and protein degradation during sepsis.
    The Journal of surgical research, 1988, Volume: 45, Issue:1

    Topics: Animals; Bacterial Infections; Cathepsin B; Indomethacin; Leupeptins; Muscle Proteins; Muscles; Oligopeptides; Reference Values

1988
Thrombin inhibition with dipeptidyl argininals.
    Thrombosis research, 1988, May-15, Volume: 50, Issue:4

    Topics: Antipain; Blood Coagulation; Kinetics; Leupeptins; Oligopeptides; Thrombin

1988
Treatment of experimental autoimmune myasthenia gravis in rabbits with leupeptin, a protease inhibitor.
    Journal of the neurological sciences, 1987, Volume: 82, Issue:1-3

    Topics: Animals; Antibodies; Autoimmune Diseases; Leupeptins; Male; Myasthenia Gravis; Oligopeptides; Rabbits; Receptors, Cholinergic

1987
Protease and cyclooxygenase inhibitors synergistically prevent activation of human platelets.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:10

    Topics: Blood Platelets; Collagen; Humans; In Vitro Techniques; Indomethacin; Leupeptins; Oligopeptides; Platelet Aggregation; Secretory Rate; Serotonin; Thrombin

1986
The effects of ascorbic acid on the intracellular metabolism of iron and ferritin.
    The Journal of biological chemistry, 1986, Oct-25, Volume: 261, Issue:30

    Topics: Animals; Ascorbic Acid; Cell Line; Deferoxamine; Dose-Response Relationship, Drug; Ferritins; Iron; Leukemia, Erythroblastic, Acute; Leupeptins; Methionine

1986
Phosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol 12-myristate 13-acetate.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:11

    Topics: Cytoskeletal Proteins; Humans; Leupeptins; Molecular Weight; Neutrophils; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate

1987
Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:15

    Topics: Acetamides; Animals; Calcium; Cell Differentiation; Cells, Cultured; Hemoglobins; Leukemia, Erythroblastic, Acute; Leupeptins; Mice; Phospholipids; Protein Kinase C; Tetradecanoylphorbol Acetate

1987
Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:3

    Topics: Animals; Bile; Chloroquine; Leupeptins; Liver; Male; Organoids; Peptides; Rats; Transforming Growth Factors

1987
Inhibition of H-ras oncogene transformation of NIH3T3 cells by protease inhibitors.
    Cancer research, 1987, Jun-15, Volume: 47, Issue:12

    Topics: alpha 1-Antitrypsin; Aminocaproic Acid; Animals; Antipain; Cell Division; Cell Line; Drug Resistance; Leupeptins; Neomycin; Oncogenes; Plasmids; Protease Inhibitors; Transfection

1987
Target-selective cytotoxicity of methotrexate conjugated with monoclonal anti-MM46 antibody.
    Cancer immunology, immunotherapy : CII, 1987, Volume: 25, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Cell Line; Immunotoxins; Leupeptins; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C3H

1987
Schistosoma mansoni: purification and characterization of the major acidic proteinase from adult worms.
    Experimental parasitology, 1986, Volume: 61, Issue:3

    Topics: Animals; Chromatography, Gel; Cysteine Endopeptidases; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Female; Helminth Proteins; Hemoglobins; Hydrogen-Ion Concentration; Isoelectric Point; Kinetics; Leupeptins; Male; Molecular Weight; Peptides; Protease Inhibitors; Schistosoma mansoni; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone

1986
Morphometric assessment of drug effects in experimental spinal cord injury.
    Journal of neurosurgery, 1986, Volume: 65, Issue:1

    Topics: Animals; Axons; Leucine; Leupeptins; Male; Methylprednisolone; Methylprednisolone Hemisuccinate; Rats; Rats, Inbred Strains; Spinal Cord Injuries

1986
Pinocytosis and degradation of exogenous proteins by cystinotic fibroblasts.
    Biochimica et biophysica acta, 1986, Jul-11, Volume: 887, Issue:2

    Topics: Cells, Cultured; Cysteine Endopeptidases; Cystinosis; Endopeptidases; Humans; Leupeptins; Lysosomes; Pinocytosis; Proteins; Skin

1986
Inhibition of proteolytic enzymes in the in vitro amnion model for basement membrane invasion.
    Cancer research, 1986, Volume: 46, Issue:8

    Topics: Amnion; Animals; Basement Membrane; Blood Physiological Phenomena; Cathepsin B; Cathepsins; Cell Membrane; Cysteine Endopeptidases; Endopeptidases; Female; Humans; In Vitro Techniques; Leupeptins; Melanoma; Mice; Neoplasm Invasiveness; Plasminogen Activators; Pregnancy; Protease Inhibitors; Serine Endopeptidases; Urokinase-Type Plasminogen Activator

1986
A protease acting on the estrogen receptor may modify its action in the adult rabbit epididymis.
    Journal of steroid biochemistry, 1986, Volume: 25, Issue:4

    Topics: Aging; Animals; Cell Nucleus; Centrifugation, Density Gradient; Epididymis; Estradiol; Estrogens; Genitalia, Male; In Vitro Techniques; Leupeptins; Male; Orchiectomy; Peptide Hydrolases; Rabbits; Receptors, Estrogen

1986
Physiological role of thiol proteases in thyroid hormone secretion.
    Acta endocrinologica, 1986, Volume: 113, Issue:2

    Topics: Acid Phosphatase; Animals; Centrifugation, Density Gradient; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Leupeptins; Lysosomes; Male; Rats; Rats, Inbred Strains; Thyroid Gland; Thyroxine; Triiodothyronine

1986
Induction and inhibition of cathepsin B and hemoglobin-hydrolase activity in murine B16 melanoma by thiol protease inhibitors.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1986, Volume: 85, Issue:2

    Topics: Animals; Antipain; Cathepsin B; Kinetics; Leucine; Leupeptins; Melanoma, Experimental; Mice; Oligopeptides; Peptide Hydrolases; Protease Inhibitors

1986
The bovine lens neutral proteinase comprises a family of cysteine-dependent proteolytic activities.
    Current eye research, 1986, Volume: 5, Issue:11

    Topics: Animals; Cattle; Cysteine; Endopeptidases; Hydrolysis; Lens, Crystalline; Leupeptins; Neprilysin; Nitrobenzenes; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Substrate Specificity; Trypsin

1986
Plasmodium falciparum: protease inhibitors and inhibition of erythrocyte invasion.
    Experimental parasitology, 1986, Volume: 62, Issue:3

    Topics: Animals; Chymotrypsin; Erythrocytes; Humans; In Vitro Techniques; Leupeptins; Oligopeptides; Plasmodium falciparum; Protease Inhibitors; Trypsin

1986
Effect of leupeptin, a protease inhibitor, on dopa decarboxylase and protease activities in homogenates of submandibular salivary glands from young rats.
    Archives of oral biology, 1986, Volume: 31, Issue:7

    Topics: Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Dopa Decarboxylase; Female; Leupeptins; Male; Oligopeptides; Peptide Hydrolases; Rats; Rats, Inbred Strains; Submandibular Gland

1986
Biosynthesis and maturation of glucocerebrosidase in Gaucher fibroblasts.
    European journal of biochemistry, 1987, Apr-01, Volume: 164, Issue:1

    Topics: Cell Line; Cross Reactions; Fibroblasts; Gaucher Disease; Glucosidases; Glucosylceramidase; Humans; Immunosorbent Techniques; Leupeptins; Methionine; Molecular Weight; Mutation

1987
Leukocyte protease activities in myotonic dystrophy: studies on effects of protease inhibitors.
    European neurology, 1987, Volume: 26, Issue:2

    Topics: Aspartic Acid Endopeptidases; Endopeptidases; Granulocytes; Humans; Leukocytes; Leupeptins; Mercuric Chloride; Monocytes; Myotonic Dystrophy; Neprilysin; Oligopeptides; Pepstatins; Protease Inhibitors

1987
Significant effects of Z-Gln-Val-Val-OME, common sequences of thiol proteinase inhibitors on thiol proteinases.
    Biochemical and biophysical research communications, 1987, Mar-13, Volume: 143, Issue:2

    Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cathepsin B; Cystatins; Kininogens; Leupeptins; Oligopeptides; Papain; Protease Inhibitors; Proteins; Structure-Activity Relationship

1987
A tripeptide protease inhibitor attenuates conditioned avoidance behavior.
    Brain research, 1987, Mar-17, Volume: 406, Issue:1-2

    Topics: Animals; Avoidance Learning; Conditioning, Classical; Depression, Chemical; Injections, Intraventricular; Leupeptins; Male; Memory; Oligopeptides; Protease Inhibitors; Time Factors

1987
A putative protein-sequestration site involving intermediate filaments for protein degradation by autophagy. Studies with microinjected purified glycolytic enzymes in 3T3-L1 cells.
    The Biochemical journal, 1987, Feb-01, Volume: 241, Issue:3

    Topics: Autophagy; Binding Sites; Cell Fractionation; Cell Line; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Glyceraldehyde-3-Phosphate Dehydrogenases; Intermediate Filaments; L-Lactate Dehydrogenase; Leupeptins; Microinjections; Phagocytosis; Proteins; Pyruvate Kinase; Serum Albumin, Bovine

1987
Mode of action of bestatin and leupeptin to induce the accumulation of acid soluble peptides in rat liver in vivo and the properties of the accumulated peptides. The important role of bestatin- and leupeptin-sensitive proteases in the protein degradation
    The International journal of biochemistry, 1987, Volume: 19, Issue:5

    Topics: Aminopeptidases; Animals; Glucagon; Kinetics; Leucine; Leupeptins; Liver; Male; Models, Biological; Oligopeptides; Peptide Mapping; Peptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Solubility

1987
The role of microtubules in the phagocytosis of collagen by fibroblasts.
    Collagen and related research, 1987, Volume: 7, Issue:1

    Topics: Animals; Bone and Bones; Cells, Cultured; Colchicine; Collagen; Cytochalasin B; Cytoplasmic Granules; Fibroblasts; Leupeptins; Mice; Microscopy, Electron; Microtubules; Phagocytosis; Vacuoles; Vinblastine

1987
[Effect of leupeptin on protein uptake and the degradation of the visceral yolk sac epithelium of the rat].
    Zeitschrift fur mikroskopisch-anatomische Forschung, 1987, Volume: 101, Issue:1

    Topics: Animals; Epithelium; Female; Horseradish Peroxidase; Leupeptins; Oligopeptides; Pregnancy; Proteins; Rats; Rats, Inbred Strains; Yolk Sac

1987
Sperm chymotrypsin-like enzymes of different inhibitor-susceptibility as lysins in ascidians.
    Experientia, 1987, Aug-15, Volume: 43, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Chymotrypsin; Enzyme Inhibitors; Fertilization; Leupeptins; Male; Oligopeptides; Peptides; Spermatozoa; Urochordata

1987
Enhancement of neuromuscular recovery after nerve repair in primates.
    Journal of hand surgery (Edinburgh, Scotland), 1987, Volume: 12, Issue:2

    Topics: Animals; Axons; Blood Coagulation; Cebus; Leupeptins; Median Nerve; Muscles; Myelin Sheath; Nerve Regeneration; Neural Conduction; Oligopeptides

1987
Leupeptin inhibits the transformation of glucocorticoid receptor.
    Journal of steroid biochemistry, 1987, Volume: 28, Issue:3

    Topics: Adrenalectomy; Animals; Cellulose; Centrifugation, Density Gradient; Chromatography, Affinity; Cytosol; DNA; Kinetics; Leupeptins; Liver; Male; Molybdenum; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Triamcinolone Acetonide

1987
Ascorbic acid inhibits lysosomal autophagy of ferritin.
    The Journal of biological chemistry, 1987, Oct-25, Volume: 262, Issue:30

    Topics: Ascorbic Acid; Cell Line; Cytoplasm; Ferritins; Glucuronidase; Iron; Leupeptins; Lysosomes; Proteins

1987
Effect of leupeptin on platelet aggregation, fibrin formation and amidolysis induced by thrombin.
    Thrombosis research, 1987, Sep-01, Volume: 47, Issue:5

    Topics: Blood Platelets; Dipeptides; Fibrin; Humans; In Vitro Techniques; Leupeptins; Oligopeptides; Platelet Aggregation; Thrombin

1987
Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity--formation of crinosomes.
    Experimental and molecular pathology, 1987, Volume: 47, Issue:3

    Topics: Animals; Autophagy; Chloroquine; Leupeptins; Lipid Metabolism; Liver; Lysosomes; Microscopy, Electron; Phagocytosis; Proteins; Rats; Vacuoles; Vinblastine

1987
Influence of a calcium dependent protease inhibitor on platelet activation and secretion.
    Thrombosis research, 1987, Sep-15, Volume: 47, Issue:6

    Topics: Blood Coagulation; Blood Platelets; Calcium; Cytosol; Dipeptides; Glycoproteins; Humans; Hydrolysis; Leupeptins; Oligopeptides; Platelet Aggregation; Serotonin; Therapeutic Irrigation; Thrombin

1987
Vascular permeability changes by proteinase inhibitors in carrageenin-induced inflammation in rats.
    Agents and actions, 1986, Volume: 17, Issue:5-6

    Topics: Animals; Capillary Permeability; Carrageenan; Inflammation; Kinetics; Leupeptins; Protease Inhibitors; Rats; Rats, Inbred Strains; Time Factors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone

1986
Sustained proteolysis is required for human platelet activation by thrombin.
    Thrombosis research, 1986, Apr-15, Volume: 42, Issue:2

    Topics: Blood Platelets; Humans; Indomethacin; Inositol; Kinetics; Leupeptins; Platelet Aggregation; Serotonin; Thrombin

1986
Evidence for a specific estradiol binding site on rat pituitary membranes.
    Endocrinology, 1986, Volume: 119, Issue:3

    Topics: Animals; Binding Sites; Binding, Competitive; Diethylstilbestrol; Dihydrotestosterone; Estradiol; Estriol; Estrone; Female; Hydrocortisone; Kinetics; Leupeptins; Pituitary Gland, Anterior; Progesterone; Rats; Rats, Inbred Strains; Temperature

1986
Effects of leupeptin on endocytosis and membrane recycling in rat visceral yolk-sac endoderm.
    Histochemistry, 1986, Volume: 85, Issue:2

    Topics: Animals; Cell Membrane; Cells, Cultured; Concanavalin A; Endocytosis; Endoderm; Horseradish Peroxidase; Intracellular Membranes; Leupeptins; Lysosomes; Oligopeptides; Rats; Yolk Sac

1986
Influence of agents that alter lysosomal function on fetal mouse hearts recovering from anoxia and substrate depletion.
    Journal of molecular and cellular cardiology, 1986, Volume: 18, Issue:8

    Topics: Animals; Chloroquine; Female; Fetus; Hydrocortisone; Hypoxia; Kinetics; Leupeptins; Lysosomes; Mice; Microscopy, Electron; Myocardium; Oligopeptides; Organ Culture Techniques; Pregnancy; Vacuoles

1986
Acidic lens-protein-degrading activity in aqueous humour.
    Experimental eye research, 1986, Volume: 43, Issue:2

    Topics: Animals; Aqueous Humor; Cataract; Cattle; Crystallins; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leupeptins; Pepstatins; Protease Inhibitors

1986
Preparation and purification of the proteinase inhibitor, leupeptin, from culture filtrates of Streptomyces lavendulae.
    The International journal of biochemistry, 1986, Volume: 18, Issue:9

    Topics: Carbon Radioisotopes; Culture Media; Kinetics; Leupeptins; Oligopeptides; Streptomyces; Tritium

1986
Assay of plasma leupeptin using the reversible binding of leupeptin to bovine pancreatic trypsin.
    Analytical biochemistry, 1986, Aug-01, Volume: 156, Issue:2

    Topics: Animals; Binding, Competitive; Cattle; Dogs; Kinetics; Leupeptins; Male; Oligopeptides; Pancreas; Protein Binding; Species Specificity; Trypsin

1986
Secretion-coupled protein degradation: studies on mammary casein.
    Biochimica et biophysica acta, 1986, Oct-31, Volume: 889, Issue:1

    Topics: Adenine; Amino Acids; Animals; Biological Transport; Caseins; Colchicine; Cytochalasin B; Female; Leupeptins; Mammary Glands, Animal; Organ Culture Techniques; Rabbits; Tunicamycin

1986
Processing and estrogen regulation of the 52-kilodalton protein inside MCF7 breast cancer cells.
    Endocrinology, 1986, Volume: 119, Issue:6

    Topics: Ammonium Chloride; Antibodies, Monoclonal; Breast Neoplasms; Cell Compartmentation; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation; Glycosylation; Humans; Leupeptins; Molecular Weight; Monensin; Neoplasm Proteins; Protein Processing, Post-Translational

1986
Leucine aminopeptidase and hatching of Schistosoma mansoni eggs.
    The Journal of parasitology, 1986, Volume: 72, Issue:4

    Topics: Animals; Cold Temperature; Darkness; Leucine; Leucyl Aminopeptidase; Leupeptins; Ovum; Schistosoma mansoni; Sodium Chloride

1986
Characterization of Ca2+-activated, phospholipid-dependent protein kinase C/protein kinase M in guinea pig peritoneal exudate macrophages.
    Biochemical and biophysical research communications, 1986, Dec-15, Volume: 141, Issue:2

    Topics: Animals; Calcium; Cell Compartmentation; Diglycerides; Enzyme Activation; Guinea Pigs; Kinetics; Leupeptins; Macrophages; Peptide Fragments; Peritoneal Cavity; Phorbol Esters; Phosphatidylserines; Phospholipids; Protein Kinase C

1986
In vitro cytotoxicity of a human serum albumin-mediated conjugate of methotrexate with anti-MM46 monoclonal antibody.
    Cancer research, 1987, Feb-15, Volume: 47, Issue:4

    Topics: Ammonium Chloride; Animals; Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry, Physical; Cytotoxicity, Immunologic; Leupeptins; Methotrexate; Mice; Mice, Inbred C3H; Serum Albumin

1987
On the fates of receptor-bound ovine luteinizing hormone and human chorionic gonadotropin in cultured Leydig tumor cells. Demonstration of similar rates of internalization.
    Endocrinology, 1987, Volume: 120, Issue:3

    Topics: Ammonium Chloride; Animals; Biological Transport; Chorionic Gonadotropin; Endocytosis; Kinetics; Leupeptins; Leydig Cell Tumor; Luteinizing Hormone; Male; Mice; Receptors, LH; Sheep; Sodium

1987
Degradation of short- and long-lived proteins in perfused liver and in isolated autophagic vacuoles--lysosomes.
    Experimental and molecular pathology, 1987, Volume: 46, Issue:1

    Topics: Animals; Autophagy; Chloroquine; Half-Life; Leupeptins; Liver; Lysosomes; Male; Phagocytosis; Proteins; Rats; Rats, Inbred Strains; Vacuoles

1987
Leupeptin and chymostatin inhibit mammalian protein methylesterase activity.
    Biochemical and biophysical research communications, 1987, Jan-30, Volume: 142, Issue:2

    Topics: Animals; Kinetics; Leupeptins; Oligopeptides; Protein Methyltransferases; Rats

1987
Competitive inhibition of [3H]dexamethasone binding to mammary glucocorticoid receptor by leupeptin.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1987, Volume: 184, Issue:3

    Topics: Animals; Binding, Competitive; Centrifugation, Density Gradient; Dexamethasone; Female; Goats; Kinetics; Leupeptins; Mammary Glands, Animal; Oligopeptides; Receptors, Glucocorticoid

1987
Regulation of Ca2+-dependent protein turnover in skeletal muscle by thyroxine.
    The Biochemical journal, 1986, Nov-15, Volume: 240, Issue:1

    Topics: Adenine; Animals; Calcium; Dantrolene; Female; Leupeptins; Methylamines; Muscle Proteins; Muscles; Potassium; Rats; Rats, Inbred Strains; Thyroxine

1986
Effects of proteinase inhibitors on preimplantation embryos in the rat.
    Journal of reproduction and fertility, 1985, Volume: 73, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Antipain; Blastocyst; Cystatins; Embryonic Development; Enzyme Inhibitors; Female; Glycopeptides; Leupeptins; Oligopeptides; Pepstatins; Peptides; Pregnancy; Protease Inhibitors; Rats; Rats, Inbred Strains

1985
Pharmacological dissociation of memory: anisomycin, a protein synthesis inhibitor, and leupeptin, a protease inhibitor, block different learning tasks.
    Behavioral and neural biology, 1985, Volume: 43, Issue:3

    Topics: Animals; Anisomycin; Avoidance Learning; Discrimination Learning; Injections, Subcutaneous; Leupeptins; Male; Memory; Olfactory Pathways; Oligopeptides; Protease Inhibitors; Pyrrolidines; Rats; Rats, Inbred Strains

1985
Regulation of protein breakdown by epidermal growth factor in A431 cells.
    Experimental cell research, 1985, Volume: 157, Issue:1

    Topics: Adenine; Ammonium Chloride; Autolysis; Carcinoma, Squamous Cell; Cell Line; Cycloheximide; Epidermal Growth Factor; Fibroblasts; Humans; Hydrogen-Ion Concentration; Insulin; Leupeptins; Lung; Proteins; Time Factors; Vinblastine

1985
[Inhibition of extracellular yeast proteinases by pepstatin A and leupeptin in the plate test].
    Mykosen, 1985, Volume: 28, Issue:3

    Topics: Agar; Blastomyces; Candida; Depression, Chemical; Endopeptidases; Geotrichum; Leupeptins; Mitosporic Fungi; Oligopeptides; Pepstatins; Species Specificity

1985
Lysosomal digestion of thyroglobulin: role of cathepsin D and thiol proteases.
    Endocrinology, 1985, Volume: 117, Issue:4

    Topics: Animals; Cathepsin D; Cysteine Endopeptidases; Endopeptidases; Hydrogen-Ion Concentration; Iodine; Leupeptins; Lysosomes; Mercaptoethanol; Monoiodotyrosine; Pepstatins; Pronase; Protease Inhibitors; Swine; Thyroglobulin

1985
Schistosoma japonicum: biochemistry and cytochemistry of dipeptidyl aminopeptidase-II-like activity in adults.
    Experimental parasitology, 1985, Volume: 60, Issue:2

    Topics: Animals; Cecum; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Hot Temperature; Hydrogen-Ion Concentration; Isoflurophate; Kinetics; Leupeptins; Octoxynol; Polyethylene Glycols; Schistosoma japonicum

1985
Isolation of two forms of the high-molecular-mass serine protease, ingensin, from porcine skeletal muscle.
    FEBS letters, 1985, Sep-09, Volume: 189, Issue:1

    Topics: Animals; Antipain; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, High Pressure Liquid; Coumarins; Cysteine Endopeptidases; Endopeptidases; Isoenzymes; Leucine; Leupeptins; Multienzyme Complexes; Muscles; Oligopeptides; Pepstatins; Proteasome Endopeptidase Complex; Sodium Dodecyl Sulfate; Swine

1985
Degradation of short- and long-time labelled proteins by rat liver lysosomes.
    Progress in clinical and biological research, 1985, Volume: 180

    Topics: Animals; Carbon Radioisotopes; Fructose-Bisphosphate Aldolase; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Male; Microscopy, Electron; Peptide Hydrolases; Proteins; Radioisotope Dilution Technique; Rats

1985
Comparison of proteolysis in perfused rat liver and in isolated autophagic vacuoles.
    Progress in clinical and biological research, 1985, Volume: 180

    Topics: Animals; Autophagy; Chloroquine; Leupeptins; Liver; Lysosomes; Microscopy, Electron; Organoids; Peptide Hydrolases; Phagocytosis; Rats; Vacuoles

1985
The role of lysosomes in the degradation of myofibrillar and non-myofibrillar proteins in heart.
    Progress in clinical and biological research, 1985, Volume: 180

    Topics: Adenine; Animals; Chloroquine; Fetus; Insulin; Kinetics; Leupeptins; Lysosomes; Mice; Myocardium; Myofibrils; Proteins

1985
Degradation of insulin by human fibroblasts: effects of inhibitors of pinocytosis and lysosomal activity.
    The International journal of biochemistry, 1985, Volume: 17, Issue:7

    Topics: 2,4-Dinitrophenol; Ammonium Chloride; Anti-Bacterial Agents; Biological Transport; Cells, Cultured; Dinitrophenols; Fibroblasts; Humans; Insulin; Iodine Radioisotopes; Kinetics; Leupeptins; Lysosomes; Pinocytosis; Povidone-Iodine; Skin; Sodium Fluoride

1985
Biosynthesis and intracellular transport of alpha-glucosidase and cathepsin D in normal and mutant human fibroblasts.
    European journal of biochemistry, 1985, Nov-15, Volume: 153, Issue:1

    Topics: alpha-Glucosidases; Ammonium Chloride; Biological Transport; Cathepsin D; Cell Line; Centrifugation, Density Gradient; Dipeptides; Fibroblasts; Glucosidases; Humans; Immunochemistry; Leupeptins; Lysosomes; Mutation; Organoids; Skin

1985
Acidic lens protein degrading activity in bovine ciliary body.
    Experimental eye research, 1985, Volume: 40, Issue:3

    Topics: Animals; Cattle; Chromatography; Ciliary Body; Crystallins; Cysteine; Hydrogen-Ion Concentration; Leupeptins; Pepstatins; Protease Inhibitors

1985
Diacylglycerol lipase activity in human platelet intracellular and surface membranes. Some kinetic properties and fatty acid specificity.
    FEBS letters, 1985, Jan-21, Volume: 180, Issue:1

    Topics: Blood Platelets; Cell Membrane; Centrifugation, Density Gradient; Egtazic Acid; Fatty Acids; Glutathione; Humans; Intracellular Membranes; Kinetics; Leupeptins; Lipoprotein Lipase; Substrate Specificity; Trifluoperazine

1985
Platelet cytoskeleton alpha-actinin in normal and thrombasthenic platelets: distribution and immunologic characterization.
    The Journal of laboratory and clinical medicine, 1985, Volume: 105, Issue:1

    Topics: Actinin; Animals; Blood Platelet Disorders; Blood Platelets; Cross Reactions; Edetic Acid; Fibroblasts; Humans; Immunoelectrophoresis; Leupeptins; Microscopy, Electron; Muscle, Smooth; Rabbits; Skin

1985
A study of the low beta-galactosidase activity in cystinotic fibroblasts: effects of cysteamine.
    Clinica chimica acta; international journal of clinical chemistry, 1985, Jan-15, Volume: 145, Issue:1

    Topics: beta-Galactosidase; Cells, Cultured; Cysteamine; Cystinosis; Fibroblasts; Galactosidases; Humans; Hydrolysis; Leupeptins

1985
Effect of inhibitors of proteolysis and arachidonic acid metabolism on burn-induced protein breakdown.
    Metabolism: clinical and experimental, 1985, Volume: 34, Issue:7

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Hindlimb; Ibuprofen; In Vitro Techniques; Indomethacin; Leupeptins; Lysosomes; Muscles; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Proteins; Quinacrine; Rats; Rats, Inbred Strains; Tyrosine

1985
Evidence for two pathways for stimulation of collagenolysis in bone.
    Calcified tissue international, 1985, Volume: 37, Issue:3

    Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Cartilage; In Vitro Techniques; Interleukin-1; Leupeptins; Lipopolysaccharides; Mice; Osteoclasts; Parathyroid Hormone; Proline

1985
Biochemical evidence for the presence of an actin protein in Tetrahymena pyriformis.
    Journal of cell science, 1985, Volume: 73

    Topics: Actins; Animals; Chromatography, Affinity; Deoxyribonuclease I; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Leupeptins; Microscopy, Electron; Molecular Weight; Protein Binding; Tetrahymena pyriformis

1985
Regulation of myofibrillar accumulation in chick muscle cultures: evidence for the involvement of calcium and lysosomes in non-uniform turnover of contractile proteins.
    The Journal of cell biology, 1985, Volume: 101, Issue:6

    Topics: Animals; Calcimycin; Calcium; Cells, Cultured; Chickens; Chloroquine; Contractile Proteins; Leupeptins; Lysosomes; Methylamines; Muscle Proteins; Muscles; Myosins; Tropomyosin; Troponin

1985
Molecular forms of GM2-activator protein. A study on its biosynthesis in human skin fibroblasts.
    Biological chemistry Hoppe-Seyler, 1985, Volume: 366, Issue:9

    Topics: Cells, Cultured; Endocytosis; Enzyme-Linked Immunosorbent Assay; Fibroblasts; G(M2) Activator Protein; G(M2) Ganglioside; Gangliosides; Gangliosidoses; Humans; Kinetics; Leucine; Leupeptins; Lysosomes; Pepstatins; Phenylmethylsulfonyl Fluoride; Protein Biosynthesis; Skin; Tritium

1985
Stimulation of rat Sertoli cell adenylate cyclase by germ cells in vitro.
    Biology of reproduction, 1985, Volume: 33, Issue:5

    Topics: Adenylyl Cyclases; Animals; Cell Membrane; Cells, Cultured; Enzyme Activation; Follicle Stimulating Hormone; Germ Cells; In Vitro Techniques; Indomethacin; Isoproterenol; Leupeptins; Male; Propranolol; Rats; Sertoli Cells

1985
Muscle damage induced by the ionophore A23187 can be prevented by prostaglandin inhibitors and leupeptin.
    Experientia, 1985, Dec-15, Volume: 41, Issue:12

    Topics: Actin Cytoskeleton; Animals; Calcimycin; Calcium; Leupeptins; Muscle Contraction; Muscles; Oligopeptides; Prostaglandin Antagonists; Rana pipiens

1985
Discrepancies in the catabolic pathways of human and rat high-density lipoprotein apolipoprotein A-I in the rat.
    European journal of clinical investigation, 1985, Volume: 15, Issue:6

    Topics: Animals; Apolipoprotein A-I; Apolipoproteins A; Humans; Kidney; Kinetics; Leupeptins; Lipoproteins, HDL; Liver; Male; Rats; Rats, Inbred Strains; Species Specificity; Tissue Distribution

1985
Human IgA as a heterovalent ligand: switching from the asialoglycoprotein receptor to secretory component during transport across the rat hepatocyte.
    The Journal of cell biology, 1986, Volume: 102, Issue:3

    Topics: Animals; Asialoglycoprotein Receptor; Bile; Biological Transport, Active; Cell Compartmentation; Galactose Oxidase; Humans; Immunoglobulin A; Immunoglobulin Fragments; Leupeptins; Ligands; Liver; Lysosomes; Male; Protein Binding; Rats; Rats, Inbred Strains; Receptors, Fc; Receptors, Immunologic; Secretory Component; Species Specificity; Time Factors

1986
Inhibition of the growth of human coronavirus 229E by leupeptin.
    The Journal of general virology, 1985, Volume: 66 ( Pt 2)

    Topics: Cell Line; Coronaviridae; Humans; Leupeptins; Oligopeptides; Protease Inhibitors; Viral Plaque Assay; Virus Replication

1985
Effect of amino acids and cycloheximide on changes caused by vinblastine, leupeptin and methylamine in the autophagic/lysosomal system of mouse hepatocytes in vivo.
    Experimental cell research, 1985, Volume: 157, Issue:1

    Topics: Amino Acids; Animals; Autophagy; Cycloheximide; Leupeptins; Liver; Lysosomes; Male; Methylamines; Mice; Organoids; Phagocytosis; Proteins; Vacuoles; Vinblastine

1985
Formation of a 55 000-weight cross-linked beta crystallin dimer in the Ca2+-treated lens. A model for cataract.
    Biochemistry, 1985, Mar-12, Volume: 24, Issue:6

    Topics: Animals; Calcium; Cataract; Cross Reactions; Crystallins; Electrophoresis, Polyacrylamide Gel; Lens, Crystalline; Leupeptins; Macromolecular Substances; Molecular Weight; Rabbits; Vimentin

1985
Participation of lysosomes in basal proteolysis in perfused rat liver. Discrepancy between leupeptin-induced lysosomal enlargement and inhibition of proteolysis.
    Experimental cell research, 1985, Volume: 158, Issue:1

    Topics: Amino Acids; Animals; Cytoplasmic Granules; Leupeptins; Liver; Lysosomes; Oligopeptides; Proteins; Rats

1985
Studies in vivo and in vitro on the uptake and degradation of soluble collagen alpha 1(I) chains in rat liver endothelial and Kupffer cells.
    The Biochemical journal, 1985, Jun-01, Volume: 228, Issue:2

    Topics: Animals; Antimetabolites; Cells, Cultured; Collagen; Endothelium; Iodine Radioisotopes; Kinetics; Kupffer Cells; Leupeptins; Liver; Male; Rats; Rats, Inbred Strains

1985
Metabolism of [3H]leupeptin by rat liver.
    Archives of biochemistry and biophysics, 1985, Aug-01, Volume: 240, Issue:2

    Topics: Animals; Binding, Competitive; Biological Transport, Active; Chloroquine; Leupeptins; Liver; Lysosomes; Male; Oligopeptides; Perfusion; Rats; Rats, Inbred Strains; Temperature

1985
Olfactory discrimination learning is blocked by leupeptin, a thiol protease inhibitor.
    Brain research, 1985, Jul-01, Volume: 337, Issue:2

    Topics: Animals; Brain; Calcium; Depression, Chemical; Discrimination Learning; Hippocampus; Injections, Intraventricular; Leupeptins; Male; Memory; Olfactory Pathways; Oligopeptides; Rats; Smell

1985
Affinity chromatography of urokinase on an agarose derivative coupled with pyroglutamyl-lysyl-leucyl-argininal.
    Journal of biochemistry, 1985, Volume: 97, Issue:5

    Topics: Chemical Phenomena; Chemistry; Chromatography, Affinity; Humans; Leupeptins; Ligands; Oligopeptides; Urokinase-Type Plasminogen Activator

1985
Inhibition of intracellular degradation of proteoglycans by leupeptin in rat ovarian granulosa cells.
    The Journal of biological chemistry, 1985, Sep-15, Volume: 260, Issue:20

    Topics: Animals; Female; Gonadotropins, Equine; Granulosa Cells; Kinetics; Leupeptins; Oligopeptides; Proteoglycans; Rats; Sulfur Radioisotopes

1985
Comparative effects of cathepsin inhibitors on rat embryonic development in vitro. Evidence that cathepsin D is unimportant in the proteolytic function of yolk sac.
    Journal of embryology and experimental morphology, 1985, Volume: 86

    Topics: Animals; Cathepsin D; Cathepsins; Cells, Cultured; Embryonic and Fetal Development; Hemoglobins; Hydrogen-Ion Concentration; Leupeptins; Pepstatins; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Time Factors; Yolk Sac

1985
Is a nicotinic influence involved in denervation-induced depolarization of muscle?
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1985, Volume: 5, Issue:9

    Topics: Animals; Electrophysiology; Leupeptins; Male; Membrane Potentials; Motor Endplate; Muscle Denervation; Muscles; Nicotine; Organ Culture Techniques; Parasympatholytics; Protease Inhibitors; Rats; Rats, Inbred Strains; Time Factors

1985
Rat mammary gland in culture secretes a stable high molecular weight form of cathepsin L.
    Biochemical and biophysical research communications, 1985, Aug-30, Volume: 131, Issue:1

    Topics: Animals; Cathepsin B; Cathepsin L; Cathepsins; Culture Techniques; Cysteine Endopeptidases; Diazomethane; Endopeptidases; Female; Hydrogen-Ion Concentration; Lactation; Leupeptins; Mammary Glands, Animal; Molecular Weight; Pregnancy; Rats; Rats, Inbred Strains; Substrate Specificity

1985
Specific targeting of high density lipoproteins to liver hepatocytes by incorporation of a tris-galactoside-terminated cholesterol derivative.
    The Journal of biological chemistry, 1985, Oct-05, Volume: 260, Issue:22

    Topics: Animals; Chloroquine; Cholesterol Esters; Endothelium; Humans; In Vitro Techniques; Kinetics; Kupffer Cells; Leupeptins; Lipoproteins, HDL; Lipoproteins, LDL; Liver; Male; Rats; Rats, Inbred Strains; Receptors, LDL

1985
Leupeptin selectively inhibits human platelet responses induced by thrombin and trypsin; a role for proteolytic activation of phospholipase C.
    Biochemical and biophysical research communications, 1985, Sep-30, Volume: 131, Issue:3

    Topics: Adult; Blood Platelets; Enzyme Activation; Humans; In Vitro Techniques; Inositol Phosphates; Leupeptins; Middle Aged; Oligopeptides; Phosphatidic Acids; Phosphorylation; Platelet Aggregation; Serotonin; Thrombin; Trypsin; Trypsin Inhibitors; Type C Phospholipases

1985
Alleviation of axonal damage in acute spinal cord injury by a protease inhibitor: automated morphometric analysis of drug-effects.
    Brain research, 1985, Nov-11, Volume: 347, Issue:1

    Topics: Animals; Leupeptins; Male; Oligopeptides; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Cord Injuries; Wounds, Nonpenetrating

1985
The digestion of phagocytosed collagen is inhibited by the proteinase inhibitors leupeptin and E-64.
    Collagen and related research, 1985, Volume: 5, Issue:4

    Topics: 2,2'-Dipyridyl; Animals; Ascorbic Acid; Bone and Bones; Collagen; Culture Techniques; Cycloheximide; Cytochalasin B; Fibroblasts; Leucine; Leupeptins; Mice; Microscopy, Electron; Oligopeptides; Phagocytosis; Vacuoles

1985
Reversibility of the stabilization effect of sodium molybdate on uterine estrogen and progesterone receptors of the vervet monkey.
    Journal of receptor research, 1985, Volume: 5, Issue:4

    Topics: Animals; Chlorocebus aethiops; Cytosol; Female; In Vitro Techniques; Kinetics; Leupeptins; Molybdenum; Phenylmethylsulfonyl Fluoride; Receptors, Estrogen; Receptors, Progesterone; Uterus

1985
The fate of the surface protein gp70 during entry of retrovirus into mouse fibroblasts.
    Virology, 1985, Apr-15, Volume: 142, Issue:1

    Topics: Ammonium Chloride; Animals; Cell Line; Chloroquine; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Glucosamine; Kinetics; Leucine; Leupeptins; Mice; Retroviridae; Retroviridae Proteins; Tritium; Viral Envelope Proteins

1985
Intracellular transport of asialoglycoproteins in rat hepatocytes. Evidence for two subpopulations of lysosomes.
    Experimental cell research, 1985, Volume: 161, Issue:2

    Topics: Animals; Asialoglycoproteins; Cell Fractionation; Cellobiose; Cells, Cultured; Colchicine; Depression, Chemical; Leupeptins; Liver; Lysosomes; Male; Monensin; Orosomucoid; Rats; Rats, Inbred Strains; Tyramine

1985
Trypsin-like enzyme from eggs of the ascidian (protochordate), Halocynthia roretzi. Purification, properties, and physiological role.
    The Journal of biological chemistry, 1985, Dec-15, Volume: 260, Issue:29

    Topics: Animals; Fertilization; Isoelectric Point; Leupeptins; Molecular Weight; Ovum; Protease Inhibitors; Substrate Specificity; Trypsin; Urochordata

1985
High-performance liquid chromatographic method for monitoring leupeptin in mouse serum and muscle by pre-column fluorescence derivatization with benzoin.
    Journal of chromatography, 1985, Dec-13, Volume: 345, Issue:2

    Topics: Animals; Benzoin; Chromatography, High Pressure Liquid; Leupeptins; Mice; Mice, Inbred C57BL; Muscles; Oligopeptides; Spectrometry, Fluorescence

1985
Protein degradation in the lysosome.
    Biochemical Society transactions, 1985, Volume: 13, Issue:6

    Topics: Animals; Autolysis; Hydrogen-Ion Concentration; Leupeptins; Liver; Lysosomes; Male; Phagocytosis; Proteins; Rats; Subcellular Fractions

1985
Quantitative assessment of the contribution of autophagy to intracellular protein breakdown.
    Biochemical Society transactions, 1985, Volume: 13, Issue:6

    Topics: Animals; Autolysis; Cathepsins; Cycloheximide; Cytoplasm; Drug Administration Schedule; Fasting; Homeostasis; Leupeptins; Liver; Lysosomes; Microtubules; Protein Conformation; Proteins; Rats

1985
Evidence for membrane-associated calpain I in human erythrocytes. Detection by an immunoelectrophoretic blotting method using monospecific antibody.
    Biochemistry, 1984, Jul-03, Volume: 23, Issue:14

    Topics: Antibodies, Monoclonal; Calcium; Calcium-Binding Proteins; Calpain; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Erythrocyte Membrane; Humans; Immunoelectrophoresis; Immunoglobulin G; Leupeptins; Protease Inhibitors

1984
Effects of protein-degradation inhibitors on the inactivation of tyrosine aminotransferase, tryptophan oxygenase and benzopyrene hydroxylase in isolated rat hepatocytes.
    The Biochemical journal, 1982, Jan-15, Volume: 202, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cell Separation; Cycloheximide; In Vitro Techniques; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leupeptins; Liver; Male; Methylamines; Oligopeptides; Rats; Rats, Inbred Strains; Tryptophan Oxygenase; Tyrosine Transaminase

1982
Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin.
    The Journal of biological chemistry, 1983, May-25, Volume: 258, Issue:10

    Topics: Acid Phosphatase; Aminopeptidases; Animals; Autophagy; Cathepsin D; Cathepsin H; Cathepsins; Centrifugation, Density Gradient; Cycloheximide; Cysteine Endopeptidases; Cytoplasm; Dexamethasone; Fructose-Bisphosphate Aldolase; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Male; Oligopeptides; Organoids; Phagocytosis; Rats; Rats, Inbred Strains; Tyrosine Transaminase; Vacuoles

1983
The biochemistry of memory: a new and specific hypothesis.
    Science (New York, N.Y.), 1984, Jun-08, Volume: 224, Issue:4653

    Topics: Animals; Calcium; Calpain; Carrier Proteins; Cerebral Cortex; Endopeptidases; Glutamates; Glutamic Acid; Hippocampus; Humans; Learning; Leupeptins; Memory; Microfilament Proteins; Neuronal Plasticity; Rabbits; Rats; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Membranes; Telencephalon

1984
Diacytosis of 125I-asialoorosomucoid by rat hepatocytes. A non-lysosomal pathway insensitive to inhibition by inhibitors of ligand degradation.
    Biochimica et biophysica acta, 1984, Nov-13, Volume: 805, Issue:3

    Topics: Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Cells, Cultured; Chloroquine; Colchicine; Cold Temperature; Endocytosis; Endosomes; Exocytosis; Kinetics; Leupeptins; Liver; Lysosomes; Monensin; Rats; Receptors, Immunologic

1984
Comparative studies on the calcium paradox in cardiac muscle: the effect of temperature on the different phases.
    Comparative biochemistry and physiology. A, Comparative physiology, 1984, Volume: 79, Issue:3

    Topics: Animals; Calcium; Leupeptins; Mice; Mice, Inbred BALB C; Microscopy, Electron; Myocardial Contraction; Myocardium; Perfusion; Rana temporaria; Temperature

1984
Acid proteolytic activities in mouse liver and muscle tissues after treatment with protease inhibitor leupeptin.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1984, Volume: 79, Issue:1

    Topics: Animals; Cathepsin B; Cathepsin C; Cathepsin D; Cathepsins; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Glucuronidase; Leupeptins; Liver; Male; Mice; Muscles; Oligopeptides; Peptide Hydrolases; Time Factors

1984
Evidence for exchange of inhibitors which bind to the active site of trypsin. Displacement of one inhibitor with a competitive inhibitor.
    Biochimica et biophysica acta, 1981, Dec-15, Volume: 662, Issue:2

    Topics: Aprotinin; Binding Sites; Binding, Competitive; Kinetics; Leupeptins; Ovomucin; Protein Binding; Trypsin; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitors

1981
Antiproteinase chemotherapy of acute experimental pancreatitis using the low molecular weight oligopeptide aldehyde leupeptin.
    Gut, 1982, Volume: 23, Issue:11

    Topics: Acute Disease; Animals; Aprotinin; Chromatography, Gel; Infusions, Parenteral; Leupeptins; Male; Oligopeptides; Pancreatitis; Rats; Rats, Inbred Strains

1982
Neurofilament accumulation induced in synapses by leupeptin.
    Science (New York, N.Y.), 1983, Sep-02, Volume: 221, Issue:4614

    Topics: Animals; Axonal Transport; Calpain; Cytoskeleton; Fishes; Leupeptins; Nerve Endings; Neuronal Plasticity; Oligopeptides; Protease Inhibitors; Synapses; Synaptic Transmission

1983
Factors affecting the reproducibility of androgen receptor determinations in human prostate.
    Clinica chimica acta; international journal of clinical chemistry, 1983, Jun-30, Volume: 131, Issue:1-2

    Topics: Aprotinin; Dihydrotestosterone; Estrenes; Humans; Leupeptins; Male; Methods; Metribolone; NADP; Prostate; Receptors, Androgen; Receptors, Steroid

1983
Comparative studies on the role of calcium in triggering subcellular damage in cardiac muscle.
    Comparative biochemistry and physiology. A, Comparative physiology, 1984, Volume: 77, Issue:3

    Topics: Animals; Caffeine; Calcimycin; Calcium; Dinitrophenols; Heart; Leupeptins; Mice; Mice, Inbred Strains; Mitochondria, Heart; Myocardial Contraction; Myocardium; Rana temporaria; Ruthenium Red; Subcellular Fractions

1984
Leupeptin's effect on organ weight, RNA, DNA, and protein content after long bone fracture in the rat.
    The Journal of surgical research, 1984, Volume: 36, Issue:5

    Topics: Animals; Body Weight; Diaphragm; DNA; Eating; Femoral Fractures; Leupeptins; Liver; Male; Oligopeptides; Organ Size; Proteins; Rats; Rats, Inbred Strains; RNA

1984
125I-Insulin internalization by perfused rat liver: comparison of its subcellular distribution with that of a lysosomally targeted molecule, 125I-asialofetuin.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1984, Volume: 16, Issue:10

    Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Fetuins; Insulin; Intracellular Membranes; Leupeptins; Liver; Lysosomes; Male; Perfusion; Rats; Rats, Inbred Strains; Subcellular Fractions

1984
Receptor properties of corticosteroid binder IB.
    Archives of biochemistry and biophysics, 1982, Volume: 217, Issue:1

    Topics: Animals; Antipain; Cell Nucleus; Deoxyribonuclease I; Endodeoxyribonucleases; Kidney; Leupeptins; Liver; Male; Micrococcal Nuclease; Oligodeoxyribonucleotides; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Receptors, Steroid; Spermidine

1982
Glycoprotein Ib in the Triton-insoluble (cytoskeletal) fraction of blood platelets.
    Biochimica et biophysica acta, 1984, Jun-29, Volume: 799, Issue:3

    Topics: Blood Platelets; Cytoskeleton; Edetic Acid; Glycoproteins; Humans; Immunoelectrophoresis, Two-Dimensional; Leupeptins; Membrane Proteins; Molecular Weight; Octoxynol; Platelet Membrane Glycoproteins; Polyethylene Glycols; Solubility; Thrombin

1984
High-performance affinity chromatography of plasmin and plasminogen on a hydrophilic vinyl-polymer gel coupled with p-aminobenzamidine.
    Journal of chromatography, 1984, Jun-01, Volume: 292, Issue:2

    Topics: Amidines; Benzamidines; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Fibrinolysin; Leupeptins; Plasminogen; Spectrophotometry, Ultraviolet; Trypsin Inhibitors

1984
Autolysis of calcium-activated neutral protease of chicken skeletal muscle.
    Journal of biochemistry, 1981, Volume: 90, Issue:6

    Topics: Animals; Calcium; Calpain; Chickens; Edetic Acid; Endopeptidases; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Molecular Weight; Muscles; Peptide Hydrolases; Protease Inhibitors; Temperature

1981
Calcium facilitates endogenous proteolysis of the EGF receptor-kinase.
    Molecular and cellular endocrinology, 1982, Volume: 27, Issue:3

    Topics: Animals; Calcium; Carcinoma, Squamous Cell; Cell Line; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Humans; Leupeptins; Mice; Molecular Weight; Peptide Hydrolases; Phosphorylation; Protein Kinases; Receptors, Cell Surface

1982
Proteolysis of the epidermal growth factor receptor by endogenous calcium-activated neutral protease from rat liver.
    Biochemical and biophysical research communications, 1983, May-31, Volume: 113, Issue:1

    Topics: Animals; Calpain; Endopeptidases; ErbB Receptors; Leupeptins; Liver; Male; Molecular Weight; Phosphorylation; Rats; Rats, Inbred Strains; Receptors, Cell Surface

1983
The effects of serine protease inhibitors on morphological differentiation of murine neuroblastoma cells (NB15).
    Journal of cellular physiology, 1984, Volume: 119, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Antipain; Cell Differentiation; Cyclic AMP; Isoflurophate; Leupeptins; Mice; Neuroblastoma; Trypsin Inhibitor, Kunitz Soybean

1984
Structural comparisons of wild-type and nuclear transport-defective simian virus 40 large tumor antigens.
    Virology, 1984, Apr-15, Volume: 134, Issue:1

    Topics: Adenoviridae; Amino Acid Sequence; Antigens, Viral, Tumor; Biological Transport; Cell Nucleus; Hybridization, Genetic; Leupeptins; Methionine; Mutation; Octoxynol; Peptides; Phosphopeptides; Phosphorylation; Polyethylene Glycols; Simian virus 40; Viral Proteins

1984
Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.
    The Journal of cell biology, 1984, Volume: 98, Issue:6

    Topics: Animals; Cycloheximide; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Horseradish Peroxidase; In Vitro Techniques; Kinetics; Leupeptins; Ligands; Liver; Male; Microscopy, Electron; Rats; Receptors, Cell Surface; Subcellular Fractions

1984
Leupeptin, a thiol proteinase inhibitor, causes a selective impairment of spatial maze performance in rats.
    Behavioral and neural biology, 1984, Volume: 40, Issue:1

    Topics: Animals; Avoidance Learning; Brain; Cysteine Endopeptidases; Discrimination Learning; Dose-Response Relationship, Drug; Leupeptins; Male; Mental Recall; Oligopeptides; Orientation; Protease Inhibitors; Rats; Rats, Inbred Strains; Space Perception; Synaptic Transmission

1984
Antigen conformation determines processing requirements for T-cell activation.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:21

    Topics: Ammonium Chloride; Animals; Antigens; Chloroquine; Clone Cells; Leupeptins; Lymphocyte Activation; Lysosomes; Mice; Monensin; Myoglobin; Peptide Fragments; Protein Conformation; Protein Denaturation; Structure-Activity Relationship; T-Lymphocytes

1984
Adhesion of cells to polystyrene surfaces.
    The Journal of cell biology, 1983, Volume: 97, Issue:5 Pt 1

    Topics: Animals; Bacteriological Techniques; Cell Adhesion; Cricetinae; Culture Media; Cycloheximide; Kidney; Leupeptins; Oxidation-Reduction; Polystyrenes; Trypsin

1983
Partial characterization of protease(s) in human breast cancer cytosols that can degrade estrogen and progesterone receptors selectively.
    Cancer research, 1984, Volume: 44, Issue:3

    Topics: Breast Neoplasms; Cytosol; Estradiol; Female; Humans; Kinetics; Leupeptins; Molybdenum; Peptide Hydrolases; Receptors, Estradiol; Receptors, Estrogen; Receptors, Progesterone; Substrate Specificity; Uterus

1984
Biosynthesis of intestinal microvillar proteins. Further characterization of the intracellular processing and transport.
    FEBS letters, 1984, Jan-23, Volume: 166, Issue:1

    Topics: alpha-Glucosidases; Aminopeptidases; Animals; Biological Transport; Glucosamine; Glucosidases; Glycoproteins; Intestinal Mucosa; Leupeptins; Microvilli; Molecular Weight; Multienzyme Complexes; Sucrase-Isomaltase Complex; Swine; Tunicamycin

1984
Regulatory proteolysis during corticosteroid hormone action.
    Advances in experimental medicine and biology, 1984, Volume: 167

    Topics: Adrenal Cortex Hormones; Animals; Humans; Kidney; Leupeptins; Liver; Peptide Hydrolases; Protein Conformation; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Trypsin Inhibitors

1984
Purification and characterization of hemoglobin-hydrolyzing acidic thiol protease induced by leupeptin in rat liver.
    The Journal of biological chemistry, 1984, May-10, Volume: 259, Issue:9

    Topics: Animals; Cysteine Endopeptidases; Endopeptidases; Enzyme Induction; Hemoglobins; Hydrolysis; Kinetics; Leupeptins; Liver; Male; Microscopy, Electron; Oligopeptides; Rats; Rats, Inbred Strains; Subcellular Fractions

1984
Lysosomal function in the degradation of defective collagen in cultured lung fibroblasts.
    Biochemistry, 1984, May-08, Volume: 23, Issue:10

    Topics: Cells, Cultured; Collagen; Endopeptidases; Female; Fibroblasts; Humans; Leupeptins; Lung; Lysosomes; Pepstatins; Pregnancy; Procollagen; Tosyllysine Chloromethyl Ketone

1984
Effects of the protease inhibitor leupeptin on proteolytic activities and regeneration of mouse skeletal muscles after exercise injuries.
    The American journal of pathology, 1984, Volume: 117, Issue:1

    Topics: Animals; Cathepsin B; Cathepsin D; Cathepsins; Glucuronidase; Leupeptins; Male; Mice; Muscles; Oligopeptides; Peptide Hydrolases; Physical Exertion; Regeneration; Stimulation, Chemical; Time Factors

1984
Inhibition of in-vitro fertilization of hamster oocytes by a thiol proteinase inhibitor.
    Journal of reproduction and fertility, 1984, Volume: 72, Issue:2

    Topics: Animals; Antipain; Cricetinae; Culture Media; Cystatins; Cysteine Endopeptidases; Enzyme Inhibitors; Female; Fertilization in Vitro; Leupeptins; Male; Oocytes; Protease Inhibitors; Sperm Motility; Time Factors

1984
Cytochemical demonstrations of protease in human peripheral blood cells by use of new alpha-naphthyl ester substrates.
    Histochemistry, 1983, Volume: 77, Issue:3

    Topics: Chymotrypsin; Histocytochemistry; Humans; Iodoacetates; Iodoacetic Acid; Isoflurophate; Leukocytes; Leupeptins; Lysine; Male; Naphthols; Neutrophils; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Substrate Specificity; Tyrosine

1983
Inhibition of cell adhesion in Dictyostelium discoideum by tunicamycin is prevented by leupeptin.
    Journal of biochemistry, 1983, Volume: 93, Issue:5

    Topics: Aspartic Acid Endopeptidases; Cell Adhesion; Dictyostelium; Edetic Acid; Endopeptidases; Glucosamine; Leucine; Leupeptins; Oligopeptides; Tunicamycin

1983
Mechanism of autodegradation of cell-surface macromolecules shed by human melanoma cells.
    Experimental cell research, 1984, Volume: 152, Issue:1

    Topics: Ammonium Chloride; Biological Transport; Cadaverine; Cell Line; Chloroquine; Coated Pits, Cell-Membrane; Colchicine; Cytochalasin B; Endocytosis; Humans; Leupeptins; Lysosomes; Melanoma; Membrane Proteins; Monensin; Neoplasm Proteins; Time Factors; Tunicamycin

1984
An abnormality in intracellular protein degradation in fibroblasts from patients with I-cell disease.
    Clinica chimica acta; international journal of clinical chemistry, 1984, Jul-31, Volume: 140, Issue:3

    Topics: Ammonium Chloride; Cytosol; Fibroblasts; Half-Life; Humans; Leupeptins; Lysosomes; Mucolipidoses; Pepstatins; Proteins

1984
Effects of inhibitors of protein degradation on the rate of protein synthesis in Chinese hamster ovary cells.
    Journal of cellular physiology, 1984, Volume: 121, Issue:1

    Topics: Amino Acids; Animals; Cell Line; Chloroquine; Cricetinae; Cricetulus; Female; Kinetics; Leupeptins; Oligopeptides; Ovary; Protein Biosynthesis; Proteins

1984
The proteinase inhibitors leupeptin, pepstatin A, and TLCK cause reduced collagen production in freshly isolated embryonic chick fibroblasts in suspension culture.
    Archives of biochemistry and biophysics, 1984, Volume: 233, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Animals; Chick Embryo; Collagen; Fibroblasts; In Vitro Techniques; Leupeptins; Oligopeptides; Pepstatins; Tendons; Tosyllysine Chloromethyl Ketone

1984
Heterogeneity of free valine pools for protein synthesis on free and membrane-bound polysomes in rat liver.
    Journal of biochemistry, 1984, Volume: 96, Issue:3

    Topics: Animals; Kinetics; Leupeptins; Liver; Molecular Weight; Polyribosomes; Protein Biosynthesis; Proteins; Rats; Rats, Inbred Strains; Tritium; Valine

1984
Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain.
    Science (New York, N.Y.), 1984, Nov-23, Volume: 226, Issue:4677

    Topics: Animals; Brain; Chloroquine; Leupeptins; Lysosomes; Microscopy, Electron; Oligopeptides; Rats; Rats, Inbred Strains

1984
Suppression of experimental allergic encephalomyelitis (EAE) with liposome-encapsulated protease inhibitor: therapy through the blood-brain barrier.
    Neurochemical research, 1984, Volume: 9, Issue:10

    Topics: Animals; Blood-Brain Barrier; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Leupeptins; Liposomes; Oligopeptides; Phosphatidylcholines; Sulfoglycosphingolipids

1984
Similar effects of various low-molecular-weight enzyme inhibitors on enzyme networks in dystrophic mice.
    Journal of pharmacobio-dynamics, 1984, Volume: 7, Issue:9

    Topics: Alkaline Phosphatase; Aminopeptidases; Animals; Esterases; Forelimb; Glutamyl Aminopeptidase; Glycine; Hindlimb; Leucine; Leucyl Aminopeptidase; Leupeptins; Male; Mice; Mice, Mutant Strains; Molecular Weight; Muscles; Muscular Dystrophy, Animal; Oligopeptides; Spleen

1984
Elevated ammonia release from dystrophic chicken muscle cell and fibroblast cultures.
    Muscle & nerve, 1984, Volume: 7, Issue:8

    Topics: Adenosine Deaminase; Ammonia; Animals; Cells, Cultured; Chick Embryo; Fibroblasts; Leupeptins; Muscular Dystrophy, Animal; Protein Denaturation

1984
Interrelations between the maturation of a 100 kDa nucleolar protein and pre rRNA synthesis in CHO cells.
    Nucleic acids research, 1984, Apr-11, Volume: 12, Issue:7

    Topics: Animals; Cell Line; Cell Nucleolus; Cloning, Molecular; Cricetinae; Cricetulus; DNA; DNA, Ribosomal; Female; Leupeptins; Molecular Weight; Nucleic Acid Precursors; Nucleoproteins; Oligopeptides; Ovary; Plasmids; RNA Precursors; RNA, Ribosomal; Transcription, Genetic

1984
The fate of homologous 125I-labelled immunoglobulin G within rat visceral yolk sacs incubated in vitro.
    The Biochemical journal, 1983, Sep-15, Volume: 214, Issue:3

    Topics: 2,4-Dinitrophenol; Ammonium Chloride; Animals; Dinitrophenols; Female; Immunoglobulin G; In Vitro Techniques; Iodine Radioisotopes; Leupeptins; Povidone; Pregnancy; Rats; Rotenone; Serum Albumin, Bovine; Yolk Sac

1983
Binding and degradation of doubly radioiodinated luteinizing hormone by mouse Leydig cells.
    Endocrinology, 1983, Volume: 113, Issue:5

    Topics: Animals; Leupeptins; Leydig Cells; Luteinizing Hormone; Male; Mice; Testosterone; Time Factors

1983
Inhibition of proteolysis in rat yolk sac as a cause of teratogenesis. Effects of leupeptin in vitro and in vivo.
    Journal of embryology and experimental morphology, 1983, Volume: 78

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Leucine; Leupeptins; Oligopeptides; Pinocytosis; Povidone; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Yolk Sac

1983
Endocytosis of formaldehyde-denatured serum albumin by nonparenchymal liver cells in vitro.
    Biochimica et biophysica acta, 1984, Feb-17, Volume: 803, Issue:1-2

    Topics: Animals; Endocytosis; Formaldehyde; Leupeptins; Liver; Lysosomes; Monensin; Protein Conformation; Protein Denaturation; Rats; Serum Albumin; Structure-Activity Relationship

1984
Uptake and degradation of 125I-labeled rat asialoorosomucoid by the perfused rat liver.
    Biochimica et biophysica acta, 1984, Mar-22, Volume: 798, Issue:1

    Topics: Animals; Asialoglycoproteins; Biological Transport; In Vitro Techniques; Iodine Radioisotopes; Leupeptins; Liver; Male; Orosomucoid; Perfusion; Rats; Rats, Inbred Strains

1984
Inhibition of fusion of skeletal myoblasts by tunicamycin and its reversal by N-acetylglucosamine.
    Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1984, Volume: 62, Issue:1

    Topics: Acetylglucosamine; Animals; Cell Division; Cell Fusion; Cell Line; Cell Membrane; Glucosamine; Glycoproteins; Kinetics; Leupeptins; Membrane Proteins; Molecular Weight; Muscles; Rats; Tunicamycin

1984
Inhibition of Leishmania amastigote growth by antipain and leupeptin.
    Annals of tropical medicine and parasitology, 1984, Volume: 78, Issue:1

    Topics: Animals; Antipain; Antiprotozoal Agents; Leishmania; Leupeptins; Macrophages; Mice; Microbial Sensitivity Tests; Oligopeptides; Pentamidine

1984
Role of thiols, pH and cathepsin D in the lysosomal catabolism of serum albumin.
    The Biochemical journal, 1984, Mar-15, Volume: 218, Issue:3

    Topics: Animals; Cathepsin D; Cathepsins; Cysteine; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Iodoacetamide; Kidney; Leupeptins; Liver; Lysosomes; Mice; Pepstatins; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Sulfhydryl Compounds

1984
Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers.
    Biochimica et biophysica acta, 1984, May-25, Volume: 799, Issue:1

    Topics: 2,4-Dinitrophenol; Acrylamides; Animals; Chromatography, Gel; Dinitrophenols; Female; Kinetics; Leupeptins; Pinocytosis; Polymers; Rats; Tyrosine; Yolk Sac

1984
Characterization of subfractions of autolysosomes isolated from rat liver after leupeptin treatment.
    Journal of biochemistry, 1984, Volume: 95, Issue:3

    Topics: Animals; Electrophoresis, Polyacrylamide Gel; Intracellular Membranes; Leupeptins; Lipids; Liver; Lysosomes; Male; Membrane Proteins; Oligopeptides; Rats; Rats, Inbred Strains; Solubility

1984
Degradation of proteins in rat liver mitochondrial outer membrane transplanted into different cell types. Evidence for alternative processing.
    The Biochemical journal, 1984, Jun-01, Volume: 220, Issue:2

    Topics: Ammonium Chloride; Animals; Cell Line; Cricetinae; Cycloheximide; Half-Life; Humans; Intracellular Membranes; Leucine; Leupeptins; Liver Neoplasms, Experimental; Membrane Proteins; Mice; Microscopy, Fluorescence; Mitochondria, Liver; Rats

1984
Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores.
    The Journal of biological chemistry, 1984, Aug-10, Volume: 259, Issue:15

    Topics: Amines; Ammonium Chloride; Animals; Antigens, Surface; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Humans; Ionophores; Isoantibodies; Kinetics; Leukemia, Experimental; Leupeptins; Mice; Monensin; Nigericin; Pepstatins; Protein Biosynthesis; Ricin

1984
On the mechanisms of inhibition of insulin action by small-molecular-weight trypsin inhibitors.
    Diabetes, 1982, Volume: 31, Issue:11

    Topics: Adipose Tissue; Animals; Benzamidines; Glucose; Guanidines; In Vitro Techniques; Insulin; Insulin Antagonists; Isoflurophate; Leupeptins; Molecular Weight; Rats; Tosylarginine Methyl Ester; Trypsin Inhibitors

1982
Easily releasable myofilaments from skeletal and cardiac muscles maintained in vitro. Role in myofibrillar assembly and turnover.
    The Journal of biological chemistry, 1981, Nov-25, Volume: 256, Issue:22

    Topics: Animals; Calcimycin; Cell Fractionation; Female; Leupeptins; Molecular Weight; Muscle Proteins; Muscles; Myocardium; Myofibrils; Myosins; Rats; Rats, Inbred Strains; Trypsin

1981
Molecular defect in combined beta-galactosidase and neuraminidase deficiency in man.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:15

    Topics: beta-Galactosidase; Cells, Cultured; Enzyme Precursors; Fibroblasts; Humans; Lactose Intolerance; Leupeptins; Lysosomes; Molecular Weight; Neuraminidase

1982
Degradation of [6-3H]- and [1-14C]glucosamine-labeled asialo-alpha 1-acid glycoprotein by the perfused rat liver.
    The Journal of biological chemistry, 1983, Apr-10, Volume: 258, Issue:7

    Topics: Animals; Asialoglycoproteins; Biological Transport; Carbon Radioisotopes; Glucosamine; Kinetics; Leupeptins; Liver; Male; Orosomucoid; Perfusion; Rats; Rats, Inbred Strains; Tritium

1983
Paradoxical effect of leupeptin in vivo on cathepsin B activity.
    Biochemical and biophysical research communications, 1983, Jan-14, Volume: 110, Issue:1

    Topics: Animals; Cathepsin B; Cathepsins; Kidney; Kinetics; Leupeptins; Liver; Lysosomes; Male; Mice; Mice, Inbred DBA; Muscles; Myocardium; Oligopeptides

1983
Ultrastructural studies on autolysosomes in rat hepatocytes after leupeptin treatment.
    Experimental cell research, 1983, Volume: 144, Issue:1

    Topics: Acid Phosphatase; Animals; Autophagy; Leupeptins; Liver; Lysosomes; Male; Microbodies; Microscopy, Electron; Oligopeptides; Organoids; Rats; Rats, Inbred Strains; Time Factors

1983
Degradation of acetylcholine receptors in muscle cells: effect of leupeptin on turnover rate, intracellular pool sizes, and receptor properties.
    The Journal of cell biology, 1983, Volume: 96, Issue:5

    Topics: Animals; Bungarotoxins; Cell Line; Centrifugation, Density Gradient; Leupeptins; Mice; Muscles; Oligopeptides; Receptors, Cholinergic

1983
A comparison of lysosomal involvements in the degradation of normal and abnormal endogenous proteins of differing half-lives in MRC5 cells.
    The Biochemical journal, 1983, May-15, Volume: 212, Issue:2

    Topics: Amino Acids; Cell Line; Colchicine; DNA; Fibroblasts; Half-Life; Humans; Leupeptins; Lysosomes; Methylamines; Proteins; Vinblastine

1983
Interaction of methotrexate poly(L-lysine) with transformed hepatic cells in culture.
    Archives of biochemistry and biophysics, 1982, Volume: 216, Issue:2

    Topics: Animals; Biological Transport; Cell Survival; Kinetics; Leucovorin; Leupeptins; Liver Neoplasms, Experimental; Methotrexate; Peptides; Polylysine; Rats

1982
The effects of low temperature and chloroquine on 125I-insulin degradation by the perfused rat liver.
    Archives of biochemistry and biophysics, 1981, Volume: 212, Issue:1

    Topics: Animals; Biological Transport; Chloroquine; Cold Temperature; Insulin; Kinetics; Leupeptins; Liver; Perfusion; Rats; Subcellular Fractions

1981
The degradation of endogenous and exogenous proteins in cultured smooth muscle cells.
    Biochimica et biophysica acta, 1982, Nov-24, Volume: 719, Issue:2

    Topics: Animals; Aorta, Thoracic; Cattle; Cell Line; Chloroquine; Chymotrypsin; Embryo, Mammalian; Humans; Kinetics; Leupeptins; Lipoproteins, LDL; Lysosomes; Muscle, Smooth, Vascular; Oligopeptides; Proteins

1982
Intracellular transport and degradation of 125I-Labelled denatured serum albumin in isolated nonparenchymal rat liver cells.
    Biochimica et biophysica acta, 1982, Dec-30, Volume: 721, Issue:4

    Topics: Animals; Biological Transport, Active; In Vitro Techniques; Leupeptins; Liver; Lysosomes; Male; Protein Denaturation; Rats; Rats, Inbred Strains; Serum Albumin; Subcellular Fractions

1982
The regulation of proteolysis in normal fibroblasts as they approach confluence. Evidence for the participation of the lysosomal system.
    The Biochemical journal, 1982, Dec-15, Volume: 208, Issue:3

    Topics: Ammonium Chloride; Animals; Cells, Cultured; Diazomethane; Fibroblasts; Humans; Leupeptins; Lysosomes; Mice; Pepstatins; Proteins

1982
Purification and properties of an enzyme reducing leupeptin acid to leupeptin.
    Biochimica et biophysica acta, 1981, Oct-13, Volume: 661, Issue:2

    Topics: Adenosine Triphosphate; Aldehyde Oxidoreductases; Cell Membrane; Drug Stability; Leupeptins; Molecular Weight; NADP; Oligopeptides; Oxidation-Reduction; Peptide Synthases; Streptomyces

1981
Induced cell injury and cell death as a cause of congenital malformations in rats.
    The Histochemical journal, 1981, Volume: 13, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Cathepsins; Cell Survival; Congenital Abnormalities; Dose-Response Relationship, Drug; Endocytosis; Female; Kidney; Leupeptins; Microscopy, Electron; Oligopeptides; Placenta; Pregnancy; Rats; Trypan Blue; Yolk Sac

1981
Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases.
    Hepatology (Baltimore, Md.), 1995, Volume: 22, Issue:6

    Topics: Animals; Antipain; Aprotinin; Blotting, Western; CHO Cells; Cricetinae; Endopeptidases; Enzyme-Linked Immunosorbent Assay; Hepatocyte Growth Factor; Humans; Leupeptins; Liver Failure, Acute; Macromolecular Substances; Protease Inhibitors; Protein Precursors; Recombinant Proteins; Transfection

1995
Degradation of cystathionine gamma-lyase in rat liver lysosomes: effect of leupeptin treatment.
    Biochemistry and molecular biology international, 1995, Volume: 35, Issue:6

    Topics: Animals; Cystathionine gamma-Lyase; Immunoblotting; Leupeptins; Liver; Lysosomes; Molecular Weight; Rats; Reference Values

1995
Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagine on vacuole distributions.
    Experimental cell research, 1995, Volume: 221, Issue:2

    Topics: Animals; Antigens, CD; Asparagine; Autophagy; Biomarkers; Carbonic Anhydrases; Cattle; Endocytosis; Gold Colloid; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomal Membrane Proteins; Lysosomal-Associated Membrane Protein 1; Lysosomes; Male; Membrane Glycoproteins; Microtubules; Protease Inhibitors; Rats; Rats, Wistar; Serum Albumin, Bovine; Superoxide Dismutase; Vacuoles; Vinblastine

1995
Proteolytic conversion of single chain precursor macrophage-stimulating protein to a biologically active heterodimer by contact enzymes of the coagulation cascade.
    The Journal of biological chemistry, 1994, Feb-04, Volume: 269, Issue:5

    Topics: Animals; Aprotinin; Blood Coagulation Factors; Cells, Cultured; Chemotaxis; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; Enzyme-Linked Immunosorbent Assay; Factor XIa; Factor XIIa; Growth Substances; Hepatocyte Growth Factor; Humans; Kallikreins; Kinetics; Leupeptins; Macromolecular Substances; Macrophages; Mice; Molecular Weight; Protein Precursors; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Recombinant Proteins; Serine Proteinase Inhibitors; Transfection

1994
Aging and proteolysis of oxidized proteins.
    Archives of biochemistry and biophysics, 1994, Feb-15, Volume: 309, Issue:1

    Topics: Aging; Animals; Aprotinin; Endopeptidases; Enzyme Stability; Hot Temperature; Houseflies; Hydrogen-Ion Concentration; Leupeptins; Male; Oxidation-Reduction; Protease Inhibitors; Proteins; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine

1994
Identification of targeting proteinase for rat alpha 1-macroglobulin in vivo. Mast-cell tryptase is a major component of the alpha 1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes.
    The Biochemical journal, 1994, Feb-15, Volume: 298 ( Pt 1)

    Topics: alpha-Macroglobulins; Amino Acid Sequence; Animals; Chymases; Endocytosis; Hydrogen-Ion Concentration; Leupeptins; Liver; Lysosomes; Male; Mast Cells; Molecular Sequence Data; Protease Inhibitors; Rats; Rats, Wistar; Serine Endopeptidases; Substrate Specificity; Tryptases

1994
In vitro stability of endogenous parathyroid hormone-related protein in blood and plasma.
    Annals of clinical biochemistry, 1994, Volume: 31 ( Pt 1)

    Topics: Anticoagulants; Aprotinin; Blood Specimen Collection; Edetic Acid; Heparin; Humans; Hypercalcemia; Immunoradiometric Assay; In Vitro Techniques; Infant; Leupeptins; Neoplasms; Parathyroid Hormone-Related Protein; Pepstatins; Peptide Fragments; Peptides; Protease Inhibitors; Temperature

1994
The role of proteases in stratum corneum: involvement in stratum corneum desquamation.
    Archives of dermatological research, 1994, Volume: 286, Issue:5

    Topics: Antipain; Aprotinin; Detergents; Endopeptidases; Epidermis; Ethylmaleimide; Humans; Leucine; Leupeptins; Oligopeptides; Pepstatins; Protease Inhibitors; Sunburn

1994
Human chorionic gonadotropin beta-subunit nicking enzymes in pregnancy and cancer patient serum.
    The Journal of clinical endocrinology and metabolism, 1994, Volume: 79, Issue:3

    Topics: Amino Acid Sequence; Blotting, Western; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Chromatography, Gel; Disulfides; Endopeptidases; Female; Humans; Leupeptins; Macromolecular Substances; Male; Metalloendopeptidases; Molecular Sequence Data; Neoplasms; Peptide Fragments; Phenanthrolines; Pregnancy

1994
Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells.
    The Biochemical journal, 1994, Oct-01, Volume: 303 ( Pt 1)

    Topics: Amino Acid Sequence; Ammonium Chloride; Animals; Arsenicals; Cell Line, Transformed; Chloroquine; Colchicine; Endocytosis; Epithelium; Hypertonic Solutions; Immune Sera; Immunohistochemistry; Kinetics; Leupeptins; Microscopy, Fluorescence; Molecular Sequence Data; Monensin; Peptides; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Time Factors; Transfection

1994
How MHC class II molecules reach the endocytic pathway.
    The EMBO journal, 1995, Jan-03, Volume: 14, Issue:1

    Topics: Anti-Bacterial Agents; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Biological Transport; Cell Compartmentation; Cell Membrane; Cells, Cultured; Cold Temperature; Endocytosis; Endopeptidases; Epitopes; Fluorescent Antibody Technique; Histocompatibility Antigens Class II; Hot Temperature; Humans; Leupeptins; Macrolides; Microscopy, Confocal; Microscopy, Immunoelectron; Models, Immunological; Neuraminidase; Sodium Dodecyl Sulfate

1995
Unique specificity of in vitro inhibition of mosquito midgut trypsin-like activity correlates with in vivo inhibition of malaria parasite infectivity.
    Experimental parasitology, 1995, Volume: 80, Issue:2

    Topics: Aedes; Animals; Aprotinin; Chickens; Female; Insect Vectors; Leupeptins; Plasmodium gallinaceum; Trypsin; Trypsin Inhibitors

1995
Formation of autophagosomes during degradation of excess peroxisomes induced by di-(2-ethylhexyl)-phthalate treatment. III. Fusion of early autophagosomes with lysosomal compartments.
    European journal of cell biology, 1995, Volume: 66, Issue:1

    Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Autophagy; Cell Compartmentation; Centrifugation, Density Gradient; Diethylhexyl Phthalate; Fetuins; Horseradish Peroxidase; Leupeptins; Lysosomes; Male; Microbodies; Rats; Rats, Wistar

1995
Antigen-presenting cell lines internalize peptide antigens via fluid-phase endocytosis.
    Cellular immunology, 1995, Volume: 163, Issue:1

    Topics: Animals; Antigen-Presenting Cells; Antigens; Aprotinin; Cell Line; Chromatography, Gel; Leupeptins; Mice; Peptides; Pinocytosis

1995
Heparin-binding vitronectin up-regulates latent TGF-beta production by bovine aortic endothelial cells.
    Journal of cell science, 1995, Volume: 108 ( Pt 4)

    Topics: Animals; Antibodies; Aorta; Aprotinin; Blotting, Western; Cattle; Cell Line; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Endothelium, Vascular; Extracellular Matrix Proteins; Glycoproteins; Heparin; Kinetics; Leupeptins; Membrane Glycoproteins; Thrombospondins; Transforming Growth Factor beta; Vitronectin

1995
A labile hyperphosphorylated c-Fos protein is induced in mouse fibroblast cells treated with a combination of phorbol ester and anti-tumor promoter curcumin.
    Cancer letters, 1995, Sep-04, Volume: 96, Issue:1

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antineoplastic Agents; Base Sequence; Carcinogens; Curcumin; Gene Expression; Genes, fos; Genes, jun; In Vitro Techniques; Leupeptins; Mice; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins c-fos; RNA, Messenger; Tetradecanoylphorbol Acetate

1995
The intracellular transport of MHC class II molecules in the absence of HLA-DM.
    Journal of immunology (Baltimore, Md. : 1950), 1995, Oct-15, Volume: 155, Issue:8

    Topics: Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Biological Transport; Cell Line; Histocompatibility Antigens Class II; HLA-D Antigens; HLA-DR3 Antigen; Humans; Leupeptins; Lymphocyte Activation; Protease Inhibitors; Subcellular Fractions

1995
Inhibitory effect of leupeptin on the intracellular maturation of lysosomal cathepsin L in primary cultures of rat hepatocytes.
    Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:7

    Topics: Animals; Cathepsin L; Cathepsins; Cells, Cultured; Cysteine Endopeptidases; Endopeptidases; Kinetics; Leupeptins; Liver; Lysosomes; Male; Molecular Weight; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Subcellular Fractions; Sulfur Radioisotopes

1995
T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.
    The Journal of experimental medicine, 1995, Nov-01, Volume: 182, Issue:5

    Topics: Alleles; Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Binding Sites; Epitopes; Glycine; Histocompatibility Antigens Class II; Humans; Hybrid Cells; Leupeptins; Lysine; Macromolecular Substances; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Conformation; Rats; Receptors, Antigen, T-Cell; Sequence Alignment; Structure-Activity Relationship; T-Lymphocytes; Transfection

1995
Cytosolic Ca2+ elevation and calpain inhibitors in HgCl2 injury to rat kidney proximal tubule epithelial cells.
    Pathobiology : journal of immunopathology, molecular and cellular biology, 1994, Volume: 62, Issue:5-6

    Topics: Animals; Antipain; Calcium; Calpain; Cell Survival; Cells, Cultured; Cytoplasm; Cytosol; Kidney Tubules, Proximal; Leupeptins; Male; Mercuric Chloride; Microscopy, Electron; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Rats

1994
Protection by lysosomal hydrolase inhibitors against cytotoxicity of 2-chloroethylethyl sulfide.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:7

    Topics: Alkylation; Animals; Cell Survival; Cells, Cultured; Drug Interactions; Gentamicins; Kanamycin; Leupeptins; Lysosomes; Mice; Mice, Inbred ICR; Mustard Gas; Oligopeptides; Pepstatins; Phospholipases; Protease Inhibitors; Spleen; Streptomycin; Structure-Activity Relationship; T-Lymphocytes

1995
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.
    The EMBO journal, 1995, Aug-01, Volume: 14, Issue:15

    Topics: Animals; Atrophy; B-Lymphocytes; Cathepsin D; Chimera; Fibroblasts; Gene Targeting; Ileum; Intestinal Mucosa; Leupeptins; Lysosomes; Male; Mice; Mice, Inbred C57BL; Pepstatins; RNA, Messenger; Specific Pathogen-Free Organisms; Spleen; T-Lymphocytes; Thymus Gland

1995
Kinetic study on the production and degradation of leupeptin in Streptomyces exfoliatus SMF13.
    Journal of biotechnology, 1995, Aug-15, Volume: 42, Issue:1

    Topics: Cell Division; Culture Media; Glucose; Kinetics; Leupeptins; Phosphates; Serine Endopeptidases; Streptomyces

1995
Peptidase modulation of vasoactive intestinal peptide pulmonary relaxation in tracheal superfused guinea pig lungs.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:1

    Topics: Animals; Aprotinin; Captopril; Dose-Response Relationship, Drug; Endopeptidases; Guinea Pigs; Leucine; Leupeptins; Lung; Male; Muscle Relaxation; Muscle, Smooth; Perfusion; Protease Inhibitors; Time Factors; Trachea; Trypsin Inhibitors; Vasoactive Intestinal Peptide

1993
Protective effect of the protease inhibitor leupeptin against myocardial stunning.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:1

    Topics: Animals; Calpain; Enzyme Activation; Guinea Pigs; Hemodynamics; In Vitro Techniques; Leupeptins; Male; Myocardial Reperfusion Injury; Protease Inhibitors; Reference Values

1993
Processing of endogenously synthesized hen egg-white lysozyme retained in the endoplasmic reticulum or in secretory form gives rise to a similar but not identical set of epitopes recognized by class II-restricted T cells.
    Journal of immunology (Baltimore, Md. : 1950), 1993, Oct-01, Volume: 151, Issue:7

    Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chickens; Egg Proteins; Endoplasmic Reticulum; Epitopes; Histocompatibility Antigens Class II; Leupeptins; Mice; Molecular Sequence Data; Muramidase; Peptide Fragments; T-Lymphocytes; Transfection

1993
Calpain-mediated regulation of AMPA receptors in adult rat brain.
    Neuroreport, 1994, Dec-30, Volume: 6, Issue:1

    Topics: Animals; Brain; Calcium; Calpain; Glycoproteins; Immunohistochemistry; Leupeptins; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Tissue Distribution

1994
Excystment of Paragonimus westermani metacercariae by endogenous cysteine protease.
    The Journal of parasitology, 1995, Volume: 81, Issue:2

    Topics: Animals; Chromatography, Ion Exchange; Collagen; Coumarins; Cysteine Endopeptidases; Dipeptides; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Fibronectins; Hydrogen-Ion Concentration; Iodoacetamide; Leucine; Leupeptins; Myosins; Oligopeptides; Pancreatic Elastase; Paragonimus; Temperature; Trypsin

1995
Endogenous, Ca(2+)-dependent cysteine-protease cleaves specifically the ryanodine receptor/Ca2+ release channel in skeletal muscle.
    The Journal of membrane biology, 1994, Volume: 142, Issue:3

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Calcium; Calcium Channels; Calpain; Cysteine; Dithiothreitol; Iodoacetamide; Leupeptins; Magnesium; Mercaptoethanol; Mercuric Chloride; Molecular Sequence Data; Molecular Weight; Muscle Proteins; Muscle, Skeletal; Rabbits; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sodium Chloride; Substrate Specificity

1994
Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin.
    Acta neuropathologica, 1995, Volume: 89, Issue:1

    Topics: Alzheimer Disease; Animals; Cerebral Cortex; Disease Models, Animal; Injections, Intraventricular; Leupeptins; Male; Models, Neurological; Nerve Degeneration; Neurofibrillary Tangles; Parietal Lobe; Rats; Rats, Wistar

1995
Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.
    The Journal of experimental medicine, 1995, May-01, Volume: 181, Issue:5

    Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Biological Transport; Endosomes; Histocompatibility Antigens Class II; Leupeptins; Mice; Protein Conformation; Sodium Dodecyl Sulfate

1995
A protease-dependent TCR-induced death pathway in mature lymphocytes.
    Journal of immunology (Baltimore, Md. : 1950), 1995, Jun-01, Volume: 154, Issue:11

    Topics: Animals; Antibodies, Monoclonal; Apoptosis; Calpain; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Cell Line; Cytotoxicity, Immunologic; Endopeptidases; Leupeptins; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Protease Inhibitors; Receptors, Antigen, T-Cell; T-Lymphocytes; Thymus Gland

1995
Thiol-protease inhibitors selectively inhibit presentation of antigen incorporated through B cell antigen receptors.
    Biochemical and biophysical research communications, 1995, May-16, Volume: 210, Issue:2

    Topics: Antigen Presentation; Antigens; Antipain; Cysteine Proteinase Inhibitors; Immunoglobulin M; Leupeptins; Major Histocompatibility Complex; Pinocytosis; Receptors, Antigen, B-Cell; Tumor Cells, Cultured

1995
Role of calcium-activated neutral protease (calpain) in cell death in cultured neonatal rat cardiomyocytes during metabolic inhibition.
    Circulation research, 1995, Volume: 76, Issue:6

    Topics: Animals; Animals, Newborn; Calcium; Calpain; Cell Death; Cells, Cultured; Chromatography, Affinity; Chromatography, Ion Exchange; Cysteine Proteinase Inhibitors; Enzyme Activation; Leucine; Leupeptins; Myocardium; Protease Inhibitors; Rats; Rats, Wistar

1995
Physiological roles of leupeptin and extracellular proteases in mycelium development of Streptomyces exfoliatus SMF13.
    Microbiology (Reading, England), 1995, Volume: 141 ( Pt 4)

    Topics: Amino Acid Sequence; Endopeptidases; Extracellular Space; Glucose; Leupeptins; Metalloendopeptidases; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Serine Endopeptidases; Streptomyces; Substrate Specificity; Trypsin

1995
Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases.
    Infection and immunity, 1995, Volume: 63, Issue:1

    Topics: ADP Ribose Transferases; Amino Acid Sequence; Animals; Antigens, Bacterial; Bacterial Toxins; Cathepsin B; CHO Cells; Cricetinae; Diphtheria Toxin; Dose-Response Relationship, Drug; Endopeptidases; Exotoxins; Furin; Leupeptins; Molecular Sequence Data; Peptide Fragments; Pseudomonas aeruginosa Exotoxin A; Substrate Specificity; Subtilisins; Virulence Factors

1995
Rat myoblast fusion requires exteriorized m-calpain activity.
    European journal of cell biology, 1994, Volume: 64, Issue:2

    Topics: Animals; Biological Assay; Calcium-Binding Proteins; Calpain; Cell Fusion; Cells, Cultured; Culture Media; Immunoglobulin G; Immunohistochemistry; Kinetics; Leupeptins; Muscle Fibers, Skeletal; Rats; Rats, Wistar

1994
Potentially amyloidogenic fragment of 50 kDa and intracellular processing of amyloid precursor protein in cells cultured under leupeptin.
    Brain research, 1994, Oct-03, Volume: 659, Issue:1-2

    Topics: Amyloid; Amyloidosis; Blotting, Western; Cell Line; Centrifugation, Density Gradient; Humans; Immunologic Techniques; Intracellular Membranes; Leupeptins; Molecular Weight; Peptide Fragments; Prion Proteins; Prions; Protein Precursors; Subcellular Fractions

1994
Acquisition of peptides by MHC class II polypeptides in the absence of the invariant chain.
    Journal of immunology (Baltimore, Md. : 1950), 1995, Feb-01, Volume: 154, Issue:3

    Topics: Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Differentiation, B-Lymphocyte; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Leupeptins; Molecular Sequence Data; Peptides; Precipitin Tests; Protein Binding; Rats; Sodium Dodecyl Sulfate; Transfection; Tumor Cells, Cultured

1995
Modulation of lipoxidase activity by urokinase-type plasminogen activator.
    Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 51, Issue:3

    Topics: Amino Acid Sequence; Fatty Acids, Essential; Humans; Kidney; Leupeptins; Lipid Peroxidation; Lipoxygenase; Lipoxygenase Inhibitors; Molecular Sequence Data; Neoplasms; Plant Proteins; Urokinase-Type Plasminogen Activator

1994
In vivo stimulation of I kappa B phosphorylation is not sufficient to activate NF-kappa B.
    Molecular and cellular biology, 1995, Volume: 15, Issue:3

    Topics: Amino Acid Sequence; Cell Line; Cell Nucleus; Cytosol; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Humans; I-kappa B Proteins; Immunoblotting; Kinetics; Leupeptins; Macromolecular Substances; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Oligopeptides; Phosphorylation; Transcription Factor RelA; Tumor Cells, Cultured

1995
Branched-chain-amino-acid-preferring peptidase activity of the lobster multicatalytic proteinase (proteasome) and the degradation of myofibrillar proteins.
    The Biochemical journal, 1995, Feb-15, Volume: 306 ( Pt 1)

    Topics: Amino Acids, Branched-Chain; Animals; Caseins; Cations; Endopeptidases; Hot Temperature; Leupeptins; Multienzyme Complexes; Muscle Proteins; Muscles; Myofibrils; Nephropidae; Oligopeptides; Peptide Fragments; Protease Inhibitors; Substrate Specificity; Troponin

1995
Degradation of proteasomes by lysosomes in rat liver.
    European journal of biochemistry, 1995, Feb-01, Volume: 227, Issue:3

    Topics: Animals; Cysteine Endopeptidases; Fasting; Half-Life; In Vitro Techniques; Leupeptins; Liver; Lysosomes; Male; Microscopy, Immunoelectron; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Wistar

1995
Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites.
    Experimental parasitology, 1995, Volume: 80, Issue:2

    Topics: Animals; Antimalarials; Chymotrypsin; Coumarins; Cysteine Proteinase Inhibitors; Dipeptides; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Fluorescent Dyes; Globins; Humans; Hydrolysis; Leucine; Leupeptins; Oligopeptides; Pepstatins; Plasmodium falciparum; Vacuoles

1995
Trichomonas vaginalis: amoeboid and flagellated forms synthesize similar proteinases.
    Experimental parasitology, 1995, Volume: 80, Issue:2

    Topics: Animals; Caseins; Culture Media; Cysteine Proteinase Inhibitors; Diazomethane; Endopeptidases; Leucine; Leupeptins; Lipoproteins; Trichomonas vaginalis

1995
Neuromuscular contacts of expanded motor units in rat soleus muscles are rescued by leupeptin.
    Neuroscience, 1994, Volume: 63, Issue:1

    Topics: Amino Acid Sequence; Animals; Bungarotoxins; Denervation; Leupeptins; Molecular Sequence Data; Motor Neurons; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Neuromuscular Junction; Rats; Rats, Wistar; Silicone Elastomers

1994
Peptide-antibody conjugates for tumour therapy: a MHC-class-II-restricted tetanus toxin peptide coupled to an anti-Ig light chain antibody can induce cytotoxic lysis of a human B-cell lymphoma by specific CD4 T cells.
    International journal of cancer, 1994, Jan-15, Volume: 56, Issue:2

    Topics: Amino Acid Sequence; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; CD4-Positive T-Lymphocytes; Chloroquine; Histocompatibility Antigens Class II; Humans; Immunoglobulin Light Chains; Immunotoxins; Leupeptins; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Peptides; Tetanus Toxin

1994
Increased activities of cathepsin B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of cysteine proteinases inhibitors.
    Life sciences, 1994, Volume: 55, Issue:15

    Topics: Animals; Bone Resorption; Cathepsin B; Cells, Cultured; Culture Techniques; Cycloheximide; Fibroblasts; Hydrolases; Leupeptins; Mice; Parathyroid Hormone; Protein Biosynthesis; Proteins; Rats; Rats, Wistar; Skull; Time Factors

1994
Inhibition of procollagen I degradation by colligin: a collagen-binding serpin.
    Archives of biochemistry and biophysics, 1994, Volume: 314, Issue:1

    Topics: Amino Acid Sequence; Animals; Biological Transport; Brefeldin A; Carrier Proteins; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Fibroblasts; Fibronectins; Glycoproteins; Humans; Hydrogen-Ion Concentration; Leupeptins; Microsomes, Liver; Molecular Sequence Data; Procollagen; Protease Inhibitors; Rats; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone

1994
Complement-mediated permeabilization of platelets by monoclonal antibodies to CD9: inhibition by leupeptin, and effects on the GP Ib-actin-binding protein system.
    Thrombosis research, 1994, Aug-15, Volume: 75, Issue:4

    Topics: Actins; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Blood Platelets; Cell Membrane Permeability; Complement Inactivator Proteins; Digitonin; Humans; Leupeptins; Membrane Glycoproteins; Molecular Sequence Data; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Binding; Tetraspanin 29

1994
beta-Amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin.
    Brain research, 1994, Mar-21, Volume: 640, Issue:1-2

    Topics: Amyloid beta-Protein Precursor; Animals; Antibodies, Monoclonal; Axons; Blotting, Western; Brain; Cytoplasmic Granules; Dendrites; Female; Immunohistochemistry; Injections, Intraventricular; Leupeptins; Lysosomes; Neurons; Peptide Fragments; Rats; Rats, Wistar

1994
Anti-ubiquitin immunoreactivity associates with pyramidal cell death induced by intraventricular infusion of leupeptin in rat hippocampus.
    Neuroscience research, 1994, Volume: 19, Issue:1

    Topics: Animals; Cell Death; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Learning; Leupeptins; Male; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Ubiquitins

1994
Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes.
    The Journal of cell biology, 1994, Volume: 126, Issue:1

    Topics: Acids; Ammonium Chloride; Animals; Chloroquine; Dose-Response Relationship, Drug; Endocytosis; Flagella; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Intracellular Membranes; Leupeptins; Lipoproteins, HDL; Microscopy, Immunoelectron; Models, Biological; Monensin; Organelles; Protein Binding; Trypanosoma brucei brucei

1994
Impact of lipofuscin on the retinal pigment epithelium: electroretinographic evaluation of a protease inhibition model.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1994, Volume: 232, Issue:4

    Topics: Animals; Dark Adaptation; Disease Models, Animal; Electroretinography; Female; Injections; Leupeptins; Lipofuscin; Pigment Epithelium of Eye; Rats; Retina; Vitreous Body

1994
Transcytosis and processing of intrinsic factor-cobalamin in Caco-2 cells.
    The Journal of biological chemistry, 1994, Jul-22, Volume: 269, Issue:29

    Topics: Biological Transport; Cell Line; Cell Polarity; Cytoplasm; Endocytosis; Humans; Intestinal Mucosa; Intrinsic Factor; Leupeptins; Vitamin B 12

1994
Effects of exogenous protease effectors on beef tenderness development and myofibrillar degradation and solubility.
    Journal of animal science, 1994, Volume: 72, Issue:5

    Topics: Animals; Calcimycin; Calcium; Calpain; Cathepsins; Cattle; Cysteine Proteinase Inhibitors; Diazomethane; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Glycoproteins; Leucine; Leupeptins; Male; Meat; Muscle Proteins; Muscles; Octoxynol; Pepstatins; Phenylmethylsulfonyl Fluoride; Postmortem Changes; Solubility

1994
Leupeptin inhibits phospholipases D and C activation in rat hepatocytes.
    Biochimica et biophysica acta, 1994, Aug-11, Volume: 1223, Issue:1

    Topics: Animals; Cell Membrane; Enzyme Activation; Glycerophospholipids; Guanosine 5'-O-(3-Thiotriphosphate); Leupeptins; Liver; Male; Phosphatidic Acids; Phospholipase D; Rats; Rats, Sprague-Dawley; Type C Phospholipases

1994
Inhibition of peptide binding to DR molecules by a leupeptin-induced invariant chain fragment.
    Molecular immunology, 1994, Volume: 31, Issue:12

    Topics: Amino Acid Sequence; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Line, Transformed; Histocompatibility Antigens Class II; HLA-DR Antigens; Leupeptins; Molecular Sequence Data; Particle Size; Peptide Fragments; Protein Binding

1994
Cleavage of the epidermal growth factor receptor by a membrane-bound leupeptin-sensitive protease active in nonionic detergent lysates of senescent but not young human diploid fibroblasts.
    Journal of cellular physiology, 1994, Volume: 160, Issue:3

    Topics: Cell Line; Cell Membrane; Cellular Senescence; Detergents; Diploidy; Endopeptidases; ErbB Receptors; Fibroblasts; Humans; Intracellular Membranes; Leupeptins; Ligands; Phosphorylation; Protease Inhibitors; Protein Processing, Post-Translational; Solvents; Stimulation, Chemical; Trypsin

1994
Evidence that acrosin activity is important for the development of fusibility of mammalian spermatozoa with the oolemma: inhibitor studies using the golden hamster.
    Zygote (Cambridge, England), 1993, Volume: 1, Issue:1

    Topics: Acrosin; Acrosome; Animals; Benzamidines; Cell Membrane; Cricetinae; Female; In Vitro Techniques; Leupeptins; Male; Membrane Fusion; Mesocricetus; Microscopy, Electron; Oocytes; Protease Inhibitors; Sperm-Ovum Interactions; Spermatozoa; Trypsin

1993
Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts.
    Toxicology letters, 1994, Volume: 73, Issue:3

    Topics: Animals; Cells, Cultured; Cysteine Proteinase Inhibitors; Fibroblasts; Gentamicins; Leucine; Leupeptins; Lysosomes; Phospholipids; Rats

1994
Hepatectomy impairs hepatic processing of somatostatin-14.
    American journal of surgery, 1993, Volume: 165, Issue:1

    Topics: Animals; Biological Transport; Chloroquine; Colchicine; Hepatectomy; Iodine Radioisotopes; Leupeptins; Liver; Liver Regeneration; Male; Rats; Rats, Sprague-Dawley; Somatostatin; Vinblastine

1993
Internalization and intracellular processing of an anti-B-cell lymphoma monoclonal antibody, LL2.
    International journal of cancer, 1994, Feb-15, Volume: 56, Issue:4

    Topics: 4-Chloro-7-nitrobenzofurazan; Ammonium Chloride; Antibodies, Monoclonal; Burkitt Lymphoma; Ceramides; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Golgi Apparatus; Humans; Immunoglobulin Fab Fragments; Kinetics; Leupeptins; Lymphoma, B-Cell; Lysosomes; Microscopy, Fluorescence; Tumor Cells, Cultured

1994
Regulation of pathways within cultured epithelial cells for the transcytosis of a basal membrane-bound peroxidase-polylysine conjugate.
    Journal of cell science, 1993, Volume: 106 ( Pt 4)

    Topics: Animals; Biological Transport; Brefeldin A; Cell Polarity; Cyclopentanes; Dose-Response Relationship, Drug; Endocytosis; Epithelium; Horseradish Peroxidase; Leupeptins; Models, Biological; Polylysine; Protease Inhibitors; Tetradecanoylphorbol Acetate; Time Factors

1993
pH-dependent binding constants for the inhibition of thrombin by transition state analogs.
    Advances in experimental medicine and biology, 1993, Volume: 340

    Topics: Amino Acid Sequence; Animals; Antithrombins; Arsenicals; Boronic Acids; Carboxylic Acids; Cattle; Dipeptides; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Molecular Sequence Data; Peptides; Piperidines; Thrombin

1993
Pharmacological interference with tissue hypercatabolism in tumour-bearing rats.
    The Biochemical journal, 1994, Apr-01, Volume: 299 ( Pt 1)

    Topics: Adrenalectomy; Animals; Aspirin; Blood Glucose; Body Weight; Cachexia; Cathepsin D; Cholesterol; Endopeptidases; Hormones; Insulin; Leupeptins; Male; Medroxyprogesterone Acetate; Muscle Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Wistar; Triglycerides

1994
Protein degradation in kidney proximal tubule cell monolayers.
    Biochimica et biophysica acta, 1994, Apr-28, Volume: 1221, Issue:3

    Topics: Ammonium Chloride; Animals; Cells, Cultured; Half-Life; Kidney Tubules, Proximal; Leupeptins; Proteins; Rats; Tritium

1994
Separation of lysosomes and autophagosomes by means of glycyl-phenylalanine-naphthylamide, a lysosome-disrupting cathepsin-C substrate.
    European journal of biochemistry, 1994, Apr-01, Volume: 221, Issue:1

    Topics: Animals; Autophagy; Cathepsin C; Cell Fractionation; Centrifugation; Centrifugation, Density Gradient; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Male; Methionine; Phagosomes; Rats; Rats, Wistar; Vinblastine

1994
Differential phosphorylation in normal and leukemic granulocytes in response to phorbol 12-myristate 13-acetate.
    Leukemia research, 1994, Volume: 18, Issue:5

    Topics: Autoradiography; Electrophoresis, Gel, Two-Dimensional; Granulocytes; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leupeptins; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Tetradecanoylphorbol Acetate

1994
Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1994, Volume: 32, Issue:4

    Topics: Animals; Blood; Culture Techniques; Embryo, Mammalian; Extremities; Female; Insulin; Insulin-Like Growth Factor II; Leucine; Leupeptins; Male; Methylamines; Mice; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sucrose; Vitamin A; Yolk Sac

1994
Purification and characterization of the 1,200-kDa subfragment of connectin filaments produced by 0.1 mM calcium ions.
    Journal of biochemistry, 1994, Volume: 115, Issue:2

    Topics: Actinin; Animals; Calcium Chloride; Carrier Proteins; Chickens; Chromatography, Gel; Connectin; Electrophoresis, Polyacrylamide Gel; Leupeptins; Microscopy, Fluorescence; Molecular Weight; Muscle Proteins; Myofibrils; Peptide Fragments; Protein Binding; Protein Kinases

1994
Degradation of rat C-reactive protein by macrophages.
    The Biochemical journal, 1993, Oct-01, Volume: 295 ( Pt 1)

    Topics: Animals; Biological Transport; C-Reactive Protein; Cations, Divalent; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Edetic Acid; Immunoglobulin G; Leupeptins; Macrophages, Peritoneal; Peptides; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Time Factors

1993
Formation of autophagosomes during degradation of excess peroxisomes induced by administration of dioctyl phthalate.
    European journal of cell biology, 1993, Volume: 61, Issue:1

    Topics: Animals; Autophagy; Diethylhexyl Phthalate; Histocytochemistry; Leupeptins; Liver; Male; Microbodies; Microinjections; Rats; Rats, Wistar; Vacuoles

1993
Polypeptide import and degradation by isolated lysosomes.
    The Journal of biological chemistry, 1993, Nov-05, Volume: 268, Issue:31

    Topics: Amino Acid Sequence; Biological Transport; Cell Line; Heat-Shock Proteins; Humans; In Vitro Techniques; Leupeptins; Lysosomes; Molecular Sequence Data; Peptide Fragments; Peptides; Ribonuclease, Pancreatic; Ribonucleases; Structure-Activity Relationship

1993
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
    Annals of the New York Academy of Sciences, 1993, Sep-24, Volume: 695

    Topics: Amino Acid Sequence; Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Brefeldin A; Cell Line; Colchicine; Cyclopentanes; Golgi Apparatus; Humans; Kidney; Leupeptins; Lysosomes; Molecular Sequence Data; Monensin; Nocodazole; Protein Processing, Post-Translational; Transfection

1993
Routes of excretion of neuronal lysosomal dense bodies after ventricular infusion of leupeptin in the rat: a study using ubiquitin and PGP 9.5 immunocytochemistry.
    Journal of neurocytology, 1993, Volume: 22, Issue:9

    Topics: Animals; Cerebral Ventricles; Female; Immunohistochemistry; Infusions, Parenteral; Leupeptins; Lysosomes; Microscopy, Electron; Neurons; Rats; Rats, Wistar; Thiolester Hydrolases; Ubiquitin Thiolesterase; Ubiquitins

1993
Release of DR molecules from complexes with invariant chain through the formation of a C-terminal 25 kDa invariant chain fragment.
    Molecular immunology, 1993, Volume: 30, Issue:18

    Topics: Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Compartmentation; Cell Line, Transformed; Cells, Cultured; Chromobox Protein Homolog 5; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Golgi Apparatus; Herpesvirus 4, Human; Hexosaminidases; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Leupeptins; Lysosomes; Peptide Fragments; Protein Binding; Protein Conformation; Tetanus Toxin

1993
Effect of high hydrostatic pressure on the conversion of alpha-connectin to beta-connectin.
    Journal of biochemistry, 1993, Volume: 114, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Calcium; Calpain; Connectin; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Hydrostatic Pressure; Leucine; Leupeptins; Molecular Weight; Muscle Proteins; Muscles; Protein Kinases; Rabbits

1993
Stimulation of transcytosis of the polymeric immunoglobulin receptor by dimeric IgA.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Jan-04, Volume: 91, Issue:1

    Topics: Animals; Biological Transport; Cell Line; Cell Polarity; Dogs; Epithelium; Immunoglobulin A; Immunoglobulin Fab Fragments; Leupeptins; Mutagenesis, Site-Directed; Phosphoserine; Receptors, Immunologic; Secretory Component; Structure-Activity Relationship; Transferrin

1994
Phorbol 12-myristate 13-acetate-stimulated phosphorylation of erythrocyte membrane skeletal proteins is blocked by calpain inhibitors: possible role of protein kinase M.
    The Biochemical journal, 1993, Dec-15, Volume: 296 ( Pt 3)

    Topics: Amino Acid Sequence; Blood Proteins; Calpain; Down-Regulation; Erythrocyte Membrane; Glycoproteins; Humans; In Vitro Techniques; Leupeptins; Membrane Proteins; Molecular Sequence Data; Phosphorylation; Protease Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate

1993
Kinetic studies on phagocytosis and lysosomal digestion of rod outer segments by human retinal pigment epithelial cells in vitro.
    Experimental cell research, 1994, Volume: 210, Issue:2

    Topics: alpha-Mannosidase; Animals; Aspartic Acid Endopeptidases; Cattle; Cell Membrane; Cells, Cultured; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leupeptins; Lysosomes; Mannosidases; Microscopy, Electron; Microscopy, Electron, Scanning; Pepstatins; Phagocytosis; Pigment Epithelium of Eye; Rod Cell Outer Segment; Swainsonine; Zinc

1994
Substratum acidification and proteinase activation by murine B16F10 melanoma cultures.
    Biochimica et biophysica acta, 1993, Aug-04, Volume: 1182, Issue:1

    Topics: Animals; Cathepsin B; Cell Line; Endopeptidases; Enzyme Activation; Fluoresceins; Gels; Hydrogen-Ion Concentration; Leupeptins; Mice; Serum Albumin, Bovine; Tumor Cells, Cultured

1993
Dual effect of thrombin on voltage-dependent Ca2+ channels of portal vein smooth muscle cells.
    Circulation research, 1993, Volume: 72, Issue:6

    Topics: Animals; Calcium Channels; GTP-Binding Proteins; Guanosine Diphosphate; Hirudins; In Vitro Techniques; Isradipine; Leupeptins; Membrane Potentials; Muscle, Smooth, Vascular; Portal Vein; Rats; Rats, Wistar; Thionucleotides; Thrombin; Vasoconstriction

1993
Calcium-induced degradation of the inositol (1,4,5)-trisphosphate receptor/Ca(2+)-channel.
    FEBS letters, 1993, Jun-01, Volume: 323, Issue:3

    Topics: Animals; Astrocytes; Calcium; Calcium Channels; Calpain; Cell Membrane; Cerebellum; Chromatography, Affinity; Dipeptides; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Leupeptins; Male; Molecular Weight; Neurons; Phosphorylation; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Testis; Tumor Cells, Cultured; Vas Deferens

1993
Proteolysis results in altered leak channel kinetics and elevated free calcium in mdx muscle.
    The Journal of membrane biology, 1993, Volume: 133, Issue:3

    Topics: Animals; Calcium; Calcium Channels; Calpain; Cells, Cultured; Clenbuterol; Dose-Response Relationship, Drug; Dystrophin; Feedback; Glycoproteins; Kinetics; Leupeptins; Mice; Mice, Mutant Strains; Muscles; Muscular Dystrophy, Animal

1993
Evidence for protein kinase C stimulation in rat enterocytes pretreated with heat stable enterotoxin of Escherichia coli.
    FEMS microbiology letters, 1993, Jun-15, Volume: 110, Issue:2

    Topics: Alkaloids; Animals; Bacterial Toxins; Calcium; Calmodulin; Cyclic AMP; Cyclic GMP; Diglycerides; Enterotoxins; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Intestinal Mucosa; Jejunum; Leupeptins; Magnesium; Membrane Proteins; Phosphatidylserines; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Rats; Signal Transduction; Staurosporine

1993
A system for characterizing cellular and molecular events in programmed neuronal cell death.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:9

    Topics: Animals; Apoptosis; Aurintricarboxylic Acid; Bucladesine; Cell Division; Cell Survival; Dactinomycin; DNA, Neoplasm; Epidermal Growth Factor; Fibroblast Growth Factor 2; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Nerve Growth Factors; Neurons; PC12 Cells; Time Factors; Transcription, Genetic; Video Recording

1993
Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo.
    Journal of immunology (Baltimore, Md. : 1950), 1993, Oct-15, Volume: 151, Issue:8

    Topics: Antigens, Differentiation, B-Lymphocyte; Biological Transport; Cell Line; Centrifugation, Density Gradient; Cholic Acids; Chromatography, Gel; Histocompatibility Antigens Class II; Humans; Leupeptins; Molecular Weight; Peptide Fragments

1993
X-ray crystallographic structure of a papain-leupeptin complex.
    FEBS letters, 1993, Jan-02, Volume: 315, Issue:1

    Topics: Amino Acid Sequence; Binding Sites; Crystallography; In Vitro Techniques; Leupeptins; Models, Molecular; Molecular Sequence Data; Papain; Protein Structure, Tertiary; X-Ray Diffraction

1993
Leupeptin-binding site(s) in the mammalian multicatalytic proteinase complex.
    The Biochemical journal, 1993, Jan-01, Volume: 289 ( Pt 1)

    Topics: Amino Acid Sequence; Animals; Antipain; Binding Sites; Cysteine Endopeptidases; Ethylmaleimide; Leupeptins; Liver; Molecular Sequence Data; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; Trypsin

1993
beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
    The Journal of biological chemistry, 1993, Feb-15, Volume: 268, Issue:5

    Topics: Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anti-Bacterial Agents; Base Sequence; Brefeldin A; Cell Line; Cell Membrane; Codon; Colchicine; Cyclopentanes; Golgi Apparatus; Humans; Kidney; Kinetics; Leupeptins; Molecular Sequence Data; Molecular Weight; Monensin; Oligodeoxyribonucleotides; Peptide Fragments; Sequence Deletion; Transfection

1993
Effects of brefeldin A on cleavage of invariant chain to p21 and p10 and the appearance of Ii-freed class II MHC dimers.
    Molecular immunology, 1993, Volume: 30, Issue:2

    Topics: Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; Binding Sites; Brefeldin A; Cell Compartmentation; Cyclopentanes; Golgi Apparatus; Histocompatibility Antigens Class II; Leupeptins; Tumor Cells, Cultured

1993
Successful 7-day perfusion preservation of the canine kidney.
    Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 2

    Topics: Adenosine; Allopurinol; Animals; Benzamidines; Creatinine; Dogs; Female; Glutathione; Graft Survival; Insulin; Kidney; Kidney Transplantation; Leupeptins; Mersalyl; Mitochondria; Organ Preservation; Organ Preservation Solutions; Oxygen Consumption; Perfusion; Quinacrine; Raffinose; Solutions; Time Factors

1993
Uptake of ferritin by isolated rat hepatocytes. Effect of metabolic inhibitors and iron.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1993, Volume: 16, Issue:1

    Topics: Animals; Antimetabolites; Cell Survival; Chloroquine; Endocytosis; Ferritins; Iodine Radioisotopes; Iron; Leupeptins; Liver; Monensin; Rats; Rats, Wistar; Trypan Blue

1993
Invariant chain retains MHC class II molecules in the endocytic pathway.
    Journal of immunology (Baltimore, Md. : 1950), 1993, Apr-15, Volume: 150, Issue:8 Pt 1

    Topics: Ammonium Chloride; Animals; Antigens, Differentiation, B-Lymphocyte; Cell Line; Chloroquine; Endocytosis; Histocompatibility Antigens Class II; Leupeptins; Lysosomes; Primaquine

1993
Factors affecting secretory protein production in primary cultures of rat hepatocytes.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1993, Volume: 203, Issue:1

    Topics: Amino Acids; Animals; Cells, Cultured; Culture Media; Dexamethasone; Epinephrine; Glucagon; Insulin; Kinetics; Leupeptins; Liver; Male; Rats; Rats, Sprague-Dawley; Serum Albumin; Urea

1993
Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo.
    Brain research, 1993, Apr-23, Volume: 609, Issue:1-2

    Topics: Animals; Blood Pressure; Calpain; Cells, Cultured; Glycoproteins; Hypoxia, Brain; Ischemic Attack, Transient; Leupeptins; Male; Neurons; Prosencephalon; Rats; Rats, Wistar

1993
Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes.
    The Journal of biological chemistry, 1993, Jun-25, Volume: 268, Issue:18

    Topics: 3T3 Cells; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Cycloheximide; Endoplasmic Reticulum; Golgi Apparatus; Hexosaminidases; Leupeptins; Lysosomes; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Peptide Fragments; Receptors, Erythropoietin

1993
Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:5

    Topics: Animals; Antimalarials; Cell Division; Chloroquine; Drug Resistance; Humans; Leupeptins; Orotic Acid; Plasmodium falciparum

1993
Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system.
    European journal of immunology, 1995, Volume: 25, Issue:12

    Topics: Animals; Antigen Presentation; Antigens, Differentiation, B-Lymphocyte; ATP-Binding Cassette Transporters; Cell Compartmentation; Chloroquine; Drug Resistance; Epitopes; Glycoproteins; Histocompatibility Antigens Class II; Hybridomas; Leupeptins; Lymphocyte Activation; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nucleoproteins; T-Lymphocytes; Viral Structural Proteins

1995
The mutation Gly142-->Glu in human lipoprotein lipase produces a missorted protein that is diverted to lysosomes.
    The Journal of biological chemistry, 1996, Jan-26, Volume: 271, Issue:4

    Topics: Animals; Base Sequence; Cell Compartmentation; Cells, Cultured; Chlorocebus aethiops; DNA Primers; Fluorescent Antibody Technique, Indirect; Heparin; Humans; Immunohistochemistry; Leupeptins; Lipoprotein Lipase; Lysosomes; Microscopy, Fluorescence; Molecular Sequence Data; Mutagenesis, Site-Directed; Protease Inhibitors; Structure-Activity Relationship; Transfection

1996
Intracellular generation of amyloid beta-protein from amyloid beta-protein precursor fragment by direct cleavage with beta- and gamma-secretase.
    Biochemical and biophysical research communications, 1996, Jan-05, Volume: 218, Issue:1

    Topics: Alzheimer Disease; Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Base Sequence; Cell Line; Chlorocebus aethiops; DNA Primers; Endopeptidases; Humans; Kinetics; Leupeptins; Methylamines; Molecular Sequence Data; Peptide Fragments; Polymerase Chain Reaction; Protease Inhibitors; Protein Processing, Post-Translational; Recombinant Proteins; Transfection

1996
Neuromuscular recovery after peripheral nerve repair: effects of an orally-administered peptide in a primate model.
    Journal of reconstructive microsurgery, 1995, Volume: 11, Issue:6

    Topics: Administration, Oral; Animals; Biological Availability; Calpain; Cebus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Leupeptins; Male; Median Nerve; Microsurgery; Motor Neurons; Muscle, Skeletal; Nerve Regeneration; Neural Conduction; Neuromuscular Junction; Protease Inhibitors; Wound Healing

1995
Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases.
    Biochemistry, 1996, Apr-09, Volume: 35, Issue:14

    Topics: Amino Acid Sequence; Animals; Aprotinin; Base Sequence; Benzamidines; Cattle; DNA; Electrochemistry; Enzyme Activation; Enzyme Precursors; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Leupeptins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Rats; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Thermodynamics; Trypsin; Trypsin Inhibitors

1996
Early proteolytic cleavage with loss of a C-terminal fragment underlies altered processing of the beta-galactosidase precursor in galactosialidosis.
    The Biochemical journal, 1996, Feb-01, Volume: 313 ( Pt 3)

    Topics: Animals; beta-Galactosidase; Cells, Cultured; CHO Cells; Cricetinae; Endopeptidases; Enzyme Precursors; Fibroblasts; Gangliosidosis, GM1; Humans; Leupeptins; Lysosomal Storage Diseases; Molecular Weight; Protein Processing, Post-Translational

1996
Generation of VV-hemorphin-7 from globin by peritoneal macrophages.
    FEBS letters, 1996, Mar-11, Volume: 382, Issue:1-2

    Topics: Amino Acid Sequence; Amino Acids; Animals; Cathepsin D; Cattle; Cells, Cultured; Female; Globins; Hemoglobins; Hydrolysis; Leupeptins; Lysosomes; Macrophages, Peritoneal; Mice; Molecular Sequence Data; Pepstatins; Peptide Fragments; Protease Inhibitors; Specific Pathogen-Free Organisms

1996
Intracellular degradation in the regulation of secretion of apolipoprotein B-100 by rabbit hepatocytes.
    The Biochemical journal, 1996, Mar-15, Volume: 314 ( Pt 3)

    Topics: Animals; Apolipoprotein B-100; Apolipoproteins B; Aprotinin; Cells, Cultured; Chlorides; Endoplasmic Reticulum, Rough; Endoplasmic Reticulum, Smooth; Glycoproteins; Golgi Apparatus; Homeostasis; Kinetics; Leupeptins; Liver; Methionine; Oleic Acid; Oleic Acids; Phenanthrolines; Protease Inhibitors; Rabbits; Sulfur Radioisotopes; Zinc Compounds

1996
Secretion of human intestinal angiotensin-converting enzyme and its association with the differentiation state of intestinal cells.
    The Biochemical journal, 1996, May-15, Volume: 316 ( Pt 1)

    Topics: Aprotinin; Biopsy; Cell Differentiation; Humans; Intestinal Mucosa; Intestine, Small; Isoenzymes; Lectins; Leupeptins; Microvilli; Peptidyl-Dipeptidase A; Protease Inhibitors

1996
Stabilisation of neuromuscular junctions by leupeptin increases motor unit size in partially denervated rat muscles.
    Brain research. Developmental brain research, 1995, Sep-29, Volume: 88, Issue:2

    Topics: Animals; Calpain; Cell Size; Leupeptins; Motor Neurons; Muscle Denervation; Nerve Endings; Neuromuscular Junction; Rats; Rats, Wistar

1995
Leupeptin causes an accumulation of lipofuscin-like substances and other signs of aging in kidneys of young rats: further evidence for the protease inhibitor model of aging.
    Annals of the New York Academy of Sciences, 1996, Jun-15, Volume: 786

    Topics: Aging; Animals; Kidney; Leupeptins; Lipofuscin; Male; Microscopy, Electron; Models, Biological; Protease Inhibitors; Rats; Rats, Inbred F344

1996
Efficacy of serine protease inhibitors against Cryptosporidium parvum infection in a bovine fallopian tube epithelial cell culture system.
    The Journal of parasitology, 1996, Volume: 82, Issue:4

    Topics: alpha 1-Antitrypsin; Amino Acid Chloromethyl Ketones; Animals; Antipain; Aprotinin; Cattle; Cells, Cultured; Cryptosporidium parvum; Epithelial Cells; Epithelium; Fallopian Tubes; Female; Leupeptins; Phenylmethylsulfonyl Fluoride; Serine Proteinase Inhibitors; Trypsin Inhibitors

1996
Proteinases in renal cell death.
    Journal of toxicology and environmental health, 1996, Volume: 48, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Antimycin A; Antipain; Carboxypeptidases; Cathepsin A; Cathepsin B; Cell Death; Coumarins; Cysteine; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endopeptidases; Hydrocarbons, Fluorinated; Hydroquinones; Isocoumarins; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Leucine; Leupeptins; Lysosomes; Membrane Potentials; Pepstatins; Peroxides; Rabbits; Reactive Oxygen Species; Serine Proteinase Inhibitors; tert-Butylhydroperoxide; Tosyllysine Chloromethyl Ketone

1996
Uncleaved env gp160 of human immunodeficiency virus type 1 is degraded within the Golgi apparatus but not lysosomes in COS-1 cells.
    FEBS letters, 1996, Jul-15, Volume: 390, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Cell Line; Chlorocebus aethiops; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; Gene Products, env; Genes, env; Golgi Apparatus; HIV Envelope Protein gp160; HIV-1; Humans; Kinetics; Leupeptins; Lysosomes; Macrolides; Protein Precursors; Recombinant Proteins; Time Factors; Transfection

1996
Selective uptake and degradation of c-Fos and v-Fos by rat liver lysosomes.
    FEBS letters, 1996, Jul-15, Volume: 390, Issue:1

    Topics: Animals; Cell Line; Cell-Free System; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Kinetics; Leupeptins; Liver; Lysosomes; Oncogene Proteins v-fos; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Recombinant Proteins; Transfection; Trypsin

1996
Activity-induced internalization and rapid degradation of sodium channels in cultured fetal neurons.
    The Journal of cell biology, 1996, Volume: 134, Issue:2

    Topics: Amphotericin B; Animals; Brain; Cells, Cultured; Endocytosis; Iodine Radioisotopes; Leupeptins; Neurons; Rats; Rats, Wistar; Scorpion Venoms; Scorpions; Sodium Channels; Time; Veratridine

1996
tBHP induced in vitro swelling of rat liver mitochondria.
    Molecular and cellular biochemistry, 1996, Jan-12, Volume: 154, Issue:1

    Topics: Animals; Antipain; Deferoxamine; Dibucaine; Edetic Acid; Egtazic Acid; Kinetics; Leupeptins; Male; Mitochondria, Liver; Mitochondrial Swelling; Peroxides; Phospholipases A; Phospholipases A2; Protease Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Spermine; tert-Butylhydroperoxide

1996
Vitamin A incorporation into lipofuscin-like inclusions in the retinal pigment epithelium.
    Mechanisms of ageing and development, 1995, Sep-29, Volume: 84, Issue:1

    Topics: Animals; Inclusion Bodies; Leupeptins; Lipofuscin; Male; Pigment Epithelium of Eye; Protease Inhibitors; Rats; Rats, Inbred F344; Vitamin A

1995
Trypsin-like protease of Streptomyces exfoliatus SMF13, a potential agent in mycelial differentiation.
    Microbiology (Reading, England), 1996, Volume: 142 ( Pt 7)

    Topics: Amino Acid Sequence; Endopeptidases; Glucose; Kinetics; Leupeptins; Microscopy, Electron, Scanning; Molecular Sequence Data; Mutation; Oligopeptides; Protease Inhibitors; Sequence Homology, Amino Acid; Streptomyces; Substrate Specificity; Trypsin

1996
Polarized GP2 secretion in MDCK cells via GPI targeting and apical membrane-restricted proteolysis.
    The American journal of physiology, 1996, Volume: 270, Issue:1 Pt 1

    Topics: Animals; Antipain; Aprotinin; Cell Line; Cell Membrane; Cell Polarity; Cytoplasmic Granules; Dogs; Endopeptidases; Glycosylphosphatidylinositols; GPI-Linked Proteins; Kidney; Leupeptins; Membrane Glycoproteins; Molecular Weight; Pancreas; Peptide Hydrolases; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Type C Phospholipases

1996
Inhibitors of Ca(2+)-dependent endopeptidases modulate morphine-induced effects in rats.
    European journal of pharmacology, 1996, May-23, Volume: 304, Issue:1-3

    Topics: Animals; Antipain; Drug Synergism; Leupeptins; Male; Morphine; Morphine Dependence; Pain Measurement; Pain Threshold; Protease Inhibitors; Rats; Rats, Wistar; Substance Withdrawal Syndrome

1996
Induction of apoptosis in primary culture of rat hepatocytes by protease inhibitors.
    Biochemistry and molecular biology international, 1996, Volume: 39, Issue:3

    Topics: Animals; Apoptosis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cathepsins; Cell Nucleus; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Electrophoresis, Agar Gel; Female; Glycoproteins; Leupeptins; Liver; Lysosomes; Microscopy, Fluorescence; Protease Inhibitors; Rats; Rats, Wistar; Transforming Growth Factor beta

1996
Inhibition of coronavirus MHV-A59 replication by proteinase inhibitors.
    Advances in experimental medicine and biology, 1995, Volume: 380

    Topics: Animals; Cell Line; Giant Cells; Kinetics; Leupeptins; Mice; Murine hepatitis virus; Protease Inhibitors; RNA-Dependent RNA Polymerase; RNA, Viral; Time Factors; Uridine; Viral Plaque Assay; Virus Replication

1995
ATP is required in platelet serotonin exocytosis for protein phosphorylation and priming of secretory vesicles docked on the plasma membrane.
    Journal of cell science, 1996, Volume: 109 ( Pt 1)

    Topics: Adenosine Triphosphate; Animals; Blood Platelets; Calcium; Calpain; Cattle; Cell Membrane; Culture Media; Cytoplasmic Granules; Exocytosis; Leupeptins; Magnesium; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Serotonin

1996
Different effects of modulation of mosquito (Diptera:Culicidae) trypsin activity on the infectivity of two human malaria (Hemosporidia:Plasmodidae) parasites.
    Journal of medical entomology, 1996, Volume: 33, Issue:5

    Topics: Animals; Anopheles; Chymotrypsin; Humans; Leupeptins; Plasmodium falciparum; Plasmodium vivax; Rabbits; Trypsin; Trypsin Inhibitors

1996
Two crystal structures of the leupeptin-trypsin complex.
    Protein science : a publication of the Protein Society, 1996, Volume: 5, Issue:4

    Topics: Binding Sites; Crystallography, X-Ray; Leupeptins; Oxygen; Protein Conformation; Trypsin

1996
Phorbol ester, but not endotoxin, desensitizes mannan-induced glycogenolysis in the perfused rat liver.
    Journal of biochemistry, 1996, Volume: 120, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aprotinin; Calcimycin; Colforsin; Enzyme Inhibitors; Escherichia coli; Leupeptins; Lipopolysaccharides; Liver; Liver Glycogen; Male; Mannans; Norepinephrine; Perfusion; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate

1996
Absence of lysosomal cleavage in the cytotoxicity mechanism of an immunoconjugate composed of anti-alpha-fetoprotein monoclonal antibody and vindesine analog.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:3

    Topics: alpha-Fetoproteins; Ammonium Chloride; Animals; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Cell Survival; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Endocytosis; Humans; Immunotoxins; Leupeptins; Liver; Lysosomes; Male; Rats; Rats, Wistar; Tumor Cells, Cultured; Vindesine

1996
The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft.
    Structure (London, England : 1993), 1996, Oct-15, Volume: 4, Issue:10

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Cathepsin B; Computer Simulation; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Precursors; Fruit; Hydrogen Bonding; Leucine; Leupeptins; Models, Molecular; Molecular Sequence Data; Mutation; Oligopeptides; Papain; Plant Proteins; Protein Processing, Post-Translational; Protein Structure, Secondary; Sequence Homology, Amino Acid

1996
HLA-DM is present in one-fifth the amount of HLA-DR in the class II peptide-loading compartment where it associates with leupeptin-induced peptide (LIP)-HLA-DR complexes.
    Journal of immunology (Baltimore, Md. : 1950), 1996, Dec-15, Volume: 157, Issue:12

    Topics: Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Compartmentation; Histocompatibility Antigens Class II; HLA-D Antigens; HLA-DR Antigens; Humans; Leupeptins; Macromolecular Substances; Peptide Fragments; Peptides; Precipitin Tests; Protein Binding

1996
Degradation of lactoferrin by periodontitis-associated bacteria.
    FEMS microbiology letters, 1996, Dec-01, Volume: 145, Issue:2

    Topics: Aggregatibacter actinomycetemcomitans; Bacteria; Bacteroides; Campylobacter; Capnocytophaga; Enzyme Inhibitors; Fusobacterium nucleatum; Humans; Iodoacetamide; Lactoferrin; Leupeptins; Peptostreptococcus; Periodontitis; Phenylmethylsulfonyl Fluoride; Porphyromonas gingivalis; Prevotella intermedia; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone

1996
Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport.
    The Biochemical journal, 1996, Dec-01, Volume: 320 ( Pt 2)

    Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; CHO Cells; Colchicine; Cricetinae; Dihydropyridines; Drug Resistance, Multiple; Kinetics; Leupeptins; Oligopeptides; Substrate Specificity; Vinblastine

1996
Novel anticoagulants for flow cytometric analysis of live leucocytes in whole blood.
    Cytometry, 1996, Mar-01, Volume: 23, Issue:3

    Topics: Adult; Amino Acid Chloromethyl Ketones; Anticoagulants; Aprotinin; Blood; Blood Cell Count; Citrates; Flow Cytometry; Hirudins; Humans; L-Selectin; Leukocytes; Leukocytes, Mononuclear; Leupeptins; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenylmethylsulfonyl Fluoride; Sulfones

1996
Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
    Acta medica Okayama, 1996, Volume: 50, Issue:6

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cathepsin B; Colonic Neoplasms; Dimethylhydrazines; Esters; Gabexate; Guanidines; Leupeptins; Male; Protease Inhibitors; Rats

1996
Distinct antigen MHC class II complexes generated by separate processing pathways.
    The EMBO journal, 1996, Dec-16, Volume: 15, Issue:24

    Topics: Cell Line; Chloroquine; Histocompatibility Antigens Class II; Kinetics; Leupeptins; Protein Binding; Protein Folding; Protein Processing, Post-Translational; Sodium Dodecyl Sulfate

1996
Transfer of free polymannose-type oligosaccharides from the cytosol to lysosomes in cultured human hepatocellular carcinoma HepG2 cells.
    The Journal of cell biology, 1997, Jan-13, Volume: 136, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Biological Transport; Carbohydrate Sequence; Carcinoma, Hepatocellular; Cell Fractionation; Cell Membrane Permeability; Cytosol; Enzyme Inhibitors; Golgi Apparatus; Humans; Leupeptins; Liver Neoplasms; Lysosomes; Macrolides; Mannans; Mannose; Molecular Sequence Data; Oligosaccharides; Proton-Translocating ATPases; Streptolysins; Swainsonine; Tumor Cells, Cultured

1997
Granulocytic protein p25 is a DNA-binding subunit of protein M(r) = 50,000: subcellular localization, cell and species specificity.
    The international journal of biochemistry & cell biology, 1996, Volume: 28, Issue:4

    Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antigen-Antibody Reactions; Chromobox Protein Homolog 5; DNA-Binding Proteins; Granulocytes; Humans; In Vitro Techniques; Leupeptins; Molecular Sequence Data; Pepstatins; Protease Inhibitors; Reference Values; Species Specificity; Subcellular Fractions

1996
A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins.
    The Journal of biological chemistry, 1997, Feb-28, Volume: 272, Issue:9

    Topics: Adenosine Triphosphate; Animals; Cell Compartmentation; Cytosol; Glyceraldehyde-3-Phosphate Dehydrogenases; Heat-Shock Proteins; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Liver; Lysosomes; Male; Microscopy, Electron; Rats; Rats, Wistar; Ribonuclease, Pancreatic

1997
Production of an extracellular trypsin-like protease by the fungal plant pathogen Verticillium dahliae.
    Canadian journal of microbiology, 1997, Volume: 43, Issue:3

    Topics: Amino Acid Sequence; Animals; Benzoylarginine Nitroanilide; Biomass; Chromatography, Ion Exchange; Culture Media; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Leupeptins; Milk; Mitosporic Fungi; Molecular Sequence Data; Sequence Homology, Amino Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Time Factors

1997
Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes.
    The Journal of cell biology, 1997, Apr-07, Volume: 137, Issue:1

    Topics: Animals; Antigens, Surface; Biological Transport; Cell Compartmentation; Cell Membrane; Dimerization; Electrophoresis; Histocompatibility Antigens Class II; Leupeptins; Lymphoma; Lysosomes; Mice; Microscopy, Immunoelectron; Protein Structure, Tertiary; Tumor Cells, Cultured

1997
Memory disturbance and hippocampal degeneration induced by continuous intraventricular infusion of a protease inhibitor, leupeptin.
    Brain research, 1997, Apr-18, Volume: 754, Issue:1-2

    Topics: Animals; Avoidance Learning; Axons; Cerebral Ventricles; Cytoplasmic Granules; Dendrites; Dentate Gyrus; Hippocampus; Infusions, Parenteral; Leupeptins; Lipofuscin; Memory; Memory Disorders; Motor Activity; Nerve Degeneration; Neurons; Rats; Rats, Wistar

1997
Selective increased presentation of type II collagen by leupeptin.
    International immunology, 1997, Volume: 9, Issue:4

    Topics: Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; Brefeldin A; Collagen; Cyclopentanes; Dimerization; Epitopes; Histocompatibility Antigens Class II; Immunophenotyping; Leupeptins; Lymphoma, B-Cell; Mice; Mice, Inbred DBA; Protease Inhibitors; Protein Synthesis Inhibitors; Sodium Dodecyl Sulfate; Tumor Cells, Cultured

1997
Thrombin receptor-activating peptide releases arachidonic acid from human platelets: a comparison with thrombin and trypsin.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:2

    Topics: Arachidonic Acid; Blood Platelets; Humans; Leupeptins; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Trypsin

1997
Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes.
    European journal of cell biology, 1997, Volume: 73, Issue:1

    Topics: Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Autophagy; Cell Separation; Cellobiose; Endocytosis; Iodine Radioisotopes; Leupeptins; Liver; Male; Okadaic Acid; Orosomucoid; Pinocytosis; Propylamines; Rats; Rats, Wistar; Receptors, Cell Surface; Serum Albumin, Bovine; Subcellular Fractions; Tyramine; Vinblastine

1997
Differentiation-induced changes in the content, secretion, and subcellular distribution of lysosomal cathepsins in the human colon cancer HT-29 cell line.
    Cell and tissue research, 1997, Volume: 289, Issue:1

    Topics: Ammonium Chloride; Cathepsin B; Cathepsin D; Cathepsin L; Cathepsins; Cell Differentiation; Colon; Colonic Neoplasms; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; HT29 Cells; Humans; Leupeptins; Lysosomes; Mannosephosphates

1997
Thrombin regulates nerve growth factor secretion from vascular, but not bladder smooth muscle cells.
    Cell and tissue research, 1997, Volume: 289, Issue:1

    Topics: Animals; Aorta; Aprotinin; Cells, Cultured; Hirudins; Leupeptins; Muscle, Smooth; Muscle, Smooth, Vascular; Nerve Growth Factors; Protease Inhibitors; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Thrombin; Trypsin; Urinary Bladder

1997
Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing.
    The Journal of clinical investigation, 1997, Jul-01, Volume: 100, Issue:1

    Topics: Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; CD4-Positive T-Lymphocytes; Colonic Neoplasms; Cysteine Endopeptidases; Dimerization; DNA Primers; Endopeptidases; Histocompatibility Antigens Class II; HLA-D Antigens; HLA-DQ Antigens; HLA-DR Antigens; Humans; Interferon-gamma; Intestinal Mucosa; Leupeptins; Polymerase Chain Reaction; Protease Inhibitors; Recombinant Proteins; Transfection; Tumor Cells, Cultured

1997
Effects of lysosomal protease inhibitors on the degradation of acetylated low density lipoprotein in cultured rat peritoneal macrophages.
    Journal of atherosclerosis and thrombosis, 1994, Volume: 1, Issue:1

    Topics: Acetylation; Animals; Cells, Cultured; Cholesterol; Humans; Iodine Radioisotopes; Leupeptins; Lipoproteins, LDL; Lysosomes; Macrophages, Peritoneal; Oleic Acid; Pepstatins; Protease Inhibitors; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tritium

1994
Utilization of intracellular ferritin iron for hemoglobin synthesis in developing human erythroid precursors.
    Blood, 1997, Jul-15, Volume: 90, Issue:2

    Topics: Autoradiography; Cells, Cultured; Chloroquine; Enzyme-Linked Immunosorbent Assay; Erythroblasts; Erythroid Precursor Cells; Ferritins; Flow Cytometry; Heme; Hemoglobins; Humans; Iron; Iron Radioisotopes; Kinetics; Leupeptins; Oligopeptides; Protease Inhibitors

1997
Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1997, Volume: 11, Issue:8

    Topics: Antibiotics, Antineoplastic; Antipain; Apoptosis; Ceramides; Coumarins; Daunorubicin; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; HL-60 Cells; Humans; Hydrolysis; Isocoumarins; Leupeptins; NF-kappa B; Pepstatins; Protease Inhibitors; Serine Proteinase Inhibitors; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured

1997
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism.
    The Journal of experimental medicine, 1997, Aug-18, Volume: 186, Issue:4

    Topics: Amino Acid Sequence; Animals; Antigens, Differentiation, B-Lymphocyte; Cathepsin D; Cathepsins; Cricetinae; Cysteine Proteinase Inhibitors; Histocompatibility Antigens Class II; Leupeptins; Mice; Molecular Sequence Data; Polymorphism, Genetic; Rabbits

1997
Interaction of combinations of drugs, chemosensitizers, and peptides with the P-glycoprotein multidrug transporter.
    Biochemical pharmacology, 1997, Jun-15, Volume: 53, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Membrane; Colchicine; Cyclosporine; Drug Interactions; Drug Resistance, Multiple; Leupeptins; Oligopeptides; Peptides; Reserpine; Valinomycin; Vinblastine

1997
MHC class II-associated invariant chain-induced enlarged endosomal structures: a morphological study.
    Experimental cell research, 1997, Aug-25, Volume: 235, Issue:1

    Topics: Adenine; Antigens, CD; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Endocytosis; Endosomes; Fibroblasts; HLA-DR alpha-Chains; HLA-DR Antigens; Humans; Immunohistochemistry; Leupeptins; Lysosomal Membrane Proteins; Lysosomes; Macromolecular Substances; Membrane Glycoproteins; Receptor, IGF Type 2; Recombinant Proteins; Transfection

1997
Efficient photoaffinity labeling of the rat V1a vasopressin receptor using a linear azidopeptidic antagonist.
    European journal of biochemistry, 1997, Aug-01, Volume: 247, Issue:3

    Topics: Affinity Labels; Animals; Antidiuretic Hormone Receptor Antagonists; Azides; Cell Membrane; COS Cells; Electrophoresis, Polyacrylamide Gel; Female; Hydrolysis; Leupeptins; Liver; Magnetic Resonance Spectroscopy; Male; Oligopeptides; Photochemistry; Rats; Rats, Wistar; Receptors, Vasopressin; Recombinant Proteins; Spectrophotometry, Ultraviolet; Spodoptera; Zinc

1997
Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.
    The Journal of clinical investigation, 1997, Sep-15, Volume: 100, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Benzimidazoles; Bradykinin; Calcium; Cells, Cultured; Chymases; Colon; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Gastrointestinal Motility; In Vitro Techniques; Indomethacin; Inflammation Mediators; Leupeptins; Mast Cells; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitroprusside; Rats; Receptor, PAR-2; Receptors, Cell Surface; Serine Endopeptidases; Substance P; Tetrodotoxin; Time Factors; Trypsin; Tryptases

1997
Myoblast fusion requires fibronectin degradation by exteriorized m-calpain.
    Experimental cell research, 1997, Sep-15, Volume: 235, Issue:2

    Topics: Animals; Calpain; Cell Fusion; Cells, Cultured; Cysteine Proteinase Inhibitors; Fibronectins; Leupeptins; Muscle, Skeletal; Peptide Fragments; Protease Inhibitors; Rabbits; Rats; Rats, Wistar

1997
Calcium homeostasis of isolated single cortical fibers of rat lens.
    Investigative ophthalmology & visual science, 1997, Volume: 38, Issue:11

    Topics: Aniline Compounds; Animals; Benzofurans; Calcium; Calcium Channel Blockers; Fluorescent Dyes; Homeostasis; Imidazoles; Lens Cortex, Crystalline; Leupeptins; Nickel; Organic Chemicals; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Verapamil; Xanthenes; Zinc

1997
Fluorometric analysis of endocytosis and lysosomal proteolysis in the rat visceral yolk sac during whole embryo culture.
    Teratology, 1997, Volume: 56, Issue:3

    Topics: Animals; Cell Culture Techniques; Embryo, Mammalian; Endocytosis; Endopeptidases; Enzyme Inhibitors; Female; Fluorescein-5-isothiocyanate; Leupeptins; Lysosomes; Microscopy, Fluorescence; Pregnancy; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Spectrometry, Fluorescence; Yolk Sac

1997
The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells.
    Life sciences, 1997, Volume: 61, Issue:20

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Carbachol; Cholinesterase Inhibitors; Culture Media, Conditioned; HeLa Cells; Humans; Immunoblotting; Leupeptins; Parasympathomimetics; Protease Inhibitors; Tacrine

1997
Oxygen deprivation inhibits Na+ current in rat hippocampal neurones via protein kinase C.
    The Journal of physiology, 1997, Sep-15, Volume: 503 ( Pt 3)

    Topics: Animals; Cell Hypoxia; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hippocampus; Isoquinolines; Leupeptins; Naphthalenes; Nerve Tissue Proteins; Neurons; Oxygen; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channels; Sulfonamides

1997
Smokeless tobacco-exposed oral keratinocytes increase macromolecular efflux from the in situ oral mucosa.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Cells, Cultured; Cheek; Cricetinae; Dextrans; Fluorescein-5-isothiocyanate; Humans; Keratinocytes; Kinetics; Leupeptins; Male; Mesocricetus; Microcirculation; Mouth Mucosa; Plants, Toxic; Tobacco, Smokeless

1998
Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Feb-17, Volume: 95, Issue:4

    Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Compartmentation; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Kidney; Leupeptins; Lysosomes; Microscopy, Confocal; Multienzyme Complexes; Opossums; Parathyroid Hormone; Phosphates; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type II; Symporters

1998
Inhibitory effects of human alpha 2-macroglobulin on Trypanosoma cruzi epimastigote proteinases.
    Acta tropica, 1997, Volume: 68, Issue:3

    Topics: alpha-Macroglobulins; Animals; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Leupeptins; Protease Inhibitors; Time Factors; Tosyl Compounds; Trypanosoma cruzi

1997
Mtv-1 superantigen trafficks independently of major histocompatibility complex class II directly to the B-cell surface by the exocytic pathway.
    Journal of virology, 1998, Volume: 72, Issue:4

    Topics: Animals; Antigen Presentation; Antigens, Viral; B-Lymphocytes; Biological Transport; Blotting, Western; Cell Membrane; Centrifugation, Density Gradient; Exocytosis; Hexosaminidases; Histocompatibility Antigens Class II; Leupeptins; Lysosomes; Mice; Sodium Dodecyl Sulfate; Superantigens; Tumor Cells, Cultured

1998
Characterization of the leupeptin-inactivating enzyme from Streptomyces exfoliatus SMF13 which produces leupeptin.
    The Biochemical journal, 1998, Apr-15, Volume: 331 ( Pt 2)

    Topics: Amino Acid Sequence; Chromatography; Edetic Acid; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Hydrolysis; Leucine; Leupeptins; Metalloendopeptidases; Microscopy, Electron, Scanning; Molecular Weight; Peptide Fragments; Phenanthrolines; Streptomyces; Substrate Specificity

1998
Carboxy-terminal truncation of long-tailed amyloid beta-peptide is inhibited by serine protease inhibitor and peptide aldehyde.
    FEBS letters, 1998, Mar-13, Volume: 424, Issue:3

    Topics: Amino Acids; Amyloid beta-Peptides; Animals; Antipain; Brain; Carboxypeptidases; Chloromercuribenzoates; Edetic Acid; Leupeptins; p-Chloromercuribenzoic Acid; Pepstatins; Peptide Fragments; Phenylmethylsulfonyl Fluoride; Rats; Serine Proteinase Inhibitors

1998
On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes.
    Mechanisms of ageing and development, 1998, Jan-30, Volume: 100, Issue:2

    Topics: Animals; Cells, Cultured; Ceroid; Exocytosis; Leupeptins; Lipofuscin; Myocardium; Rats; Rats, Sprague-Dawley; Time Factors

1998
The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase.
    Cell, 1998, Apr-03, Volume: 93, Issue:1

    Topics: Amino Acid Sequence; Aminopeptidases; Binding Sites; Carboxypeptidases; Cloning, Molecular; Crystallography, X-Ray; Cysteine Endopeptidases; DNA Primers; Escherichia coli; Kinetics; Leupeptins; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Synthases; Point Mutation; Protein Conformation; Recombinant Proteins; Sequence Deletion

1998
Calcium mediated proteolysis enhances calcium release in skinned L6 myotubes.
    Receptors & signal transduction, 1997, Volume: 7, Issue:4

    Topics: Animals; Caffeine; Calcium; Cell Line; Clone Cells; Dithiothreitol; Endopeptidases; Kinetics; Leupeptins; Muscle Contraction; Muscle, Skeletal; Protease Inhibitors; Rats; Sarcoplasmic Reticulum; Signal Transduction

1997
Deterioration of connectin/titin and nebulin filaments by an excess of protease inhibitors.
    Bioscience, biotechnology, and biochemistry, 1998, Volume: 62, Issue:5

    Topics: Animals; Calcium-Binding Proteins; Connectin; Cysteine Proteinase Inhibitors; Leupeptins; Muscle Proteins; Myofibrils; Protein Kinases; Rabbits

1998
Purification and characterisation of a tripeptidyl aminopeptidase I from rat spleen.
    Biochimica et biophysica acta, 1998, May-19, Volume: 1384, Issue:2

    Topics: Aminopeptidases; Animals; Bone Resorption; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Isoflurophate; Leupeptins; Protease Inhibitors; Rats; Serine Proteases; Spleen; Tripeptidyl-Peptidase 1

1998
Submandibular salivary proteases: lack of a role in anti-HIV activity.
    Journal of dental research, 1998, Volume: 77, Issue:7

    Topics: Anti-HIV Agents; Aprotinin; Benzamidines; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cysteine Proteinase Inhibitors; Edetic Acid; Egtazic Acid; Endopeptidases; Ethylmaleimide; HIV-1; Humans; Isoflurophate; Leupeptins; Metalloendopeptidases; Norleucine; Parotid Gland; Pepstatins; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Saliva; Serine Proteinase Inhibitors; Submandibular Gland; Trypsin Inhibitor, Bowman-Birk Soybean

1998
Cholesterol sulfate inhibits proteases that are involved in desquamation of stratum corneum.
    The Journal of investigative dermatology, 1998, Volume: 111, Issue:2

    Topics: Animals; Cholesterol Esters; Epidermis; Humans; Ichthyosis, X-Linked; Leupeptins; Male; Mice; Mice, Hairless; Oligopeptides; Serine Proteinase Inhibitors

1998
Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes.
    The Journal of biological chemistry, 1998, Aug-21, Volume: 273, Issue:34

    Topics: Ammonia; Animals; Asparagine; Endocytosis; Endosomes; Gold; Leupeptins; Liver; Male; Microscopy, Electron; Phagosomes; Propylamines; Rats; Rats, Wistar

1998
Efficient class II major histocompatibility complex presentation of endogenously synthesized hepatitis C virus core protein by Epstein-Barr virus-transformed B-lymphoblastoid cell lines to CD4(+) T cells.
    Journal of virology, 1998, Volume: 72, Issue:10

    Topics: Animals; Antigen-Presenting Cells; B-Lymphocytes; CD4-Positive T-Lymphocytes; Cell Division; Cell Line, Transformed; Chloramphenicol O-Acetyltransferase; COS Cells; Genes, Viral; Herpesvirus 4, Human; Histocompatibility Antigens Class II; Leupeptins; Viral Core Proteins; Viral Structural Proteins

1998
Endocytosed ricin and asialoorosomucoid follow different intracellular pathways in hepatocytes.
    Biochimica et biophysica acta, 1998, Aug-14, Volume: 1373, Issue:1

    Topics: Animals; Asialoglycoproteins; Centrifugation, Density Gradient; Culture Media; Endocytosis; Iodine Radioisotopes; Leupeptins; Liver; Male; Orosomucoid; Osmolar Concentration; Rats; Rats, Wistar; Ricin; Subcellular Fractions; Vinblastine

1998
Vasopressin-induced disruption of actin cytoskeletal organization and canalicular function in isolated rat hepatocyte couplets: possible involvement of protein kinase C.
    Hepatology (Baltimore, Md.), 1998, Volume: 28, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Antioxidants; Bile Canaliculi; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Indoles; Leupeptins; Liver; Male; Microscopy, Electron, Scanning; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Rats; Rats, Wistar; Tight Junctions; Vacuoles; Vasopressins

1998
Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Oct-15, Volume: 18, Issue:20

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Antibodies, Monoclonal; Aprotinin; Cathepsins; Female; Frontal Lobe; Glial Fibrillary Acidic Protein; Gliosis; In Situ Nick-End Labeling; Leupeptins; Lysosomes; Microscopy, Confocal; Neuroglia; Neurons; Neurotoxins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Thalamus

1998
Parathyroid hormone and dietary phosphate provoke a lysosomal routing of the proximal tubular Na/Pi-cotransporter type II.
    Kidney international, 1998, Volume: 54, Issue:4

    Topics: Animals; Carrier Proteins; Diet; Immunohistochemistry; Kidney Tubules, Proximal; Leupeptins; Lysosomes; Microvilli; Parathyroid Hormone; Phosphates; Rats; Sodium; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type II; Symporters

1998
Differential toxicity of protease inhibitors in cultures of cerebellar granule neurons.
    Experimental neurology, 1998, Volume: 153, Issue:2

    Topics: Animals; Apoptosis; Cells, Cultured; Cerebellum; Cysteine Proteinase Inhibitors; Dipeptides; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Leupeptins; Neurons; Oligopeptides; Protease Inhibitors; Rats; Rats, Wistar

1998
Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes.
    Shock (Augusta, Ga.), 1998, Volume: 10, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Calpain; Cathepsin B; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Deoxyglucose; Dexamethasone; Leucine; Leupeptins; Methylamines; Mifepristone; Multienzyme Complexes; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteins; Rats; Tyrosine; Ubiquitins

1998
Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (A beta) 1-42 peptide in a murine N9 microglial cell line.
    FEBS letters, 1998, Oct-09, Volume: 436, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Biological Transport; Cell Line; Cells, Cultured; Chloroquine; Kinetics; Leupeptins; Membrane Proteins; Mice; Microglia; Peptide Fragments; Polysaccharides; Rats; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class B

1998
Synthesis, assembly, and intracellular transport of the platelet glycoprotein Ib-IX-V complex.
    The Journal of biological chemistry, 1998, Nov-20, Volume: 273, Issue:47

    Topics: Biological Transport; Brefeldin A; Cell Compartmentation; Cell Line; Cell Membrane; Endoplasmic Reticulum; Golgi Apparatus; Leupeptins; Lysosomes; Platelet Glycoprotein GPIb-IX Complex; Protein Processing, Post-Translational; Recombinant Proteins; Transfection

1998
[Cell to cell transfer of dense bodies induced by intracisternal infusion of leupeptin in rat cerebellum--quantitative and ultrastructural studies].
    No to shinkei = Brain and nerve, 1998, Volume: 50, Issue:11

    Topics: Animals; Cerebellum; Cisterna Magna; Histocytochemistry; Leupeptins; Lipofuscin; Male; Neuroglia; Protease Inhibitors; Purkinje Cells; Rats; Rats, Sprague-Dawley

1998
Exposure to lysosomotropic amines and protease inhibitors retard corneal endothelial cell migration along the natural basement membrane during wound repair.
    Experimental cell research, 1999, Jan-10, Volume: 246, Issue:1

    Topics: Amines; Animals; Antipain; Basement Membrane; Cell Movement; Chloroquine; Culture Techniques; Descemet Membrane; Endopeptidases; Endothelium, Corneal; Freezing; Leupeptins; Lysosomes; Metalloendopeptidases; Methylamines; Propylamines; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Trypsin Inhibitor, Kunitz Soybean; Wound Healing

1999
Reversible accumulation of lipofuscin-like inclusions in the retinal pigment epithelium.
    Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:1

    Topics: Aging; Animals; Eye Proteins; Inclusion Bodies; Injections; Leupeptins; Lipofuscin; Male; Microscopy, Fluorescence; Pigment Epithelium of Eye; Rats; Rats, Inbred F344; Vitreous Body

1999
Degradation of serum albumin by rat liver and kidney lysosomes.
    Journal of nutritional science and vitaminology, 1998, Volume: 44, Issue:5

    Topics: Animals; Cathepsins; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Electrophoresis, Polyacrylamide Gel; Kidney; Leupeptins; Liver; Lysosomes; Male; Pepstatins; Rats; Rats, Wistar; Serum Albumin

1998
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
    Neoplasma, 1998, Volume: 45, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Animals; Carcinoma, Squamous Cell; Cathepsin B; Cathepsin C; Cathepsin L; Cathepsins; Cattle; Cystatin A; Cystatin B; Cystatin C; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Female; Humans; Kinetics; Leupeptins; Lung; Lung Neoplasms; Lysosomes; Male; Middle Aged; Sensitivity and Specificity

1998
Tyrosine kinases play a permissive role in glucose-induced insulin secretion from adult rat islets.
    Journal of molecular endocrinology, 1999, Volume: 22, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Genistein; Glucose; Insulin; Insulin Secretion; Ion Transport; Islets of Langerhans; Isoflavones; Leupeptins; Phenylmethylsulfonyl Fluoride; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates

1999
A cytomegalovirus glycoprotein re-routes MHC class I complexes to lysosomes for degradation.
    The EMBO journal, 1999, Feb-15, Volume: 18, Issue:4

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antigen Presentation; beta 2-Microglobulin; Down-Regulation; Endocytosis; Enzyme Inhibitors; Gene Expression Regulation, Viral; Genes, Viral; Histocompatibility Antigens Class I; Immunohistochemistry; Leupeptins; Lysosomes; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Muromegalovirus; Transfection; Viral Proteins

1999
Activation of Xenopus eggs by proteases: possible involvement of a sperm protease in fertilization.
    Developmental biology, 1999, Apr-01, Volume: 208, Issue:1

    Topics: Animals; Aprotinin; Calcium; Cathepsin B; Cell Division; Coumarins; Electrophysiology; Endopeptidases; Fertilization; Kinetics; Leupeptins; Male; Oligopeptides; Oocytes; Protease Inhibitors; Salamandridae; Spermatozoa; Substrate Specificity; Xenopus

1999
Acceleration of Ca2+ ionophore-induced arachidonic acid liberation by thrombin without the proteolytic action toward the receptor in human platelets.
    European journal of biochemistry, 1999, Volume: 259, Issue:3

    Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arachidonic Acid; Blood Platelets; Calcium; Enzyme Activation; Hirudins; Humans; Ionomycin; Ionophores; Leukocyte Elastase; Leupeptins; Peptide Fragments; Phospholipases A; Phospholipases A2; Platelet Glycoprotein GPIb-IX Complex; Receptor, PAR-1; Receptors, Thrombin; Thrombin; Trypsin

1999
Tissue plasminogen activator mediates reverse occlusion plasticity in visual cortex.
    Nature neuroscience, 1998, Volume: 1, Issue:1

    Topics: Animals; Animals, Newborn; Cats; Cell Size; Fibrinolysin; Geniculate Bodies; Leupeptins; Neuronal Plasticity; Plasminogen Activators; Sensory Deprivation; Tissue Plasminogen Activator; Vision, Monocular; Visual Cortex

1998
Persyn, a member of the synuclein family, influences neurofilament network integrity.
    Nature neuroscience, 1998, Volume: 1, Issue:2

    Topics: Calcium; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Endopeptidases; gamma-Synuclein; Leupeptins; Neoplasm Proteins; Nerve Tissue Proteins; Neurofilament Proteins; Neurons, Afferent

1998
Leupeptin protects sensory hair cells from acoustic trauma.
    Neuroreport, 1999, Mar-17, Volume: 10, Issue:4

    Topics: Animals; Antineoplastic Agents; Calpain; Carboplatin; Chinchilla; Enzyme Inhibitors; Hair Cells, Auditory; Hearing Disorders; Hearing Loss, Noise-Induced; Immunohistochemistry; Leupeptins; Organ of Corti

1999
Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum.
    The Journal of cell biology, 1999, Apr-19, Volume: 145, Issue:2

    Topics: Amiloride; Animals; Antimalarials; Bicarbonates; Biological Transport; Chloroquine; Erythrocyte Membrane; Erythrocytes; Hemin; Hemoglobins; Humans; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Plasmodium falciparum; Sodium-Hydrogen Exchangers; Verapamil

1999
Metabolism and degradation products of recombinant human insulin-like growth factor-I in lysosomes of rat kidney.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:3

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Glutathione; Humans; Insulin; Insulin-Like Growth Factor I; Kidney; Leupeptins; Lysosomes; Male; Microscopy, Electron; Molecular Sequence Data; Peptide Fragments; Proinsulin; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sequence Analysis

1999
Novel gelatinolytic activities in rat organs.
    Biochemistry and molecular biology international, 1999, Volume: 47, Issue:4

    Topics: Animals; Cattle; Enzyme Inhibitors; Gelatin; Leupeptins; Male; Metalloendopeptidases; Phenanthrolines; Phenylmercuric Acetate; Rats; Rats, Wistar; Serine Endopeptidases

1999
Stable expression of protective protein/cathepsin A-green fluorescent protein fusion genes in a fibroblastic cell line from a galactosialidosis patient. Model system for revealing the intracellular transport of normal and mutated lysosomal enzymes.
    The Biochemical journal, 1999, Jun-01, Volume: 340 ( Pt 2)

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; Biological Transport; Carboxypeptidases; Cathepsin A; Cell Line; DNA, Complementary; Fibroblasts; Green Fluorescent Proteins; Humans; Leupeptins; Luminescent Proteins; Lysosomal Storage Diseases; Lysosomes; Macrolides; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Mutation; Protein Processing, Post-Translational; Recombinant Fusion Proteins

1999
Modulation of major histocompatibility complex protein expression by human gamma interferon mediated by cysteine proteinase-adhesin polyproteins of Porphyromonas gingivalis.
    Infection and immunity, 1999, Volume: 67, Issue:6

    Topics: Adhesins, Bacterial; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Epitopes, B-Lymphocyte; Gingipain Cysteine Endopeptidases; Hemagglutinins; HLA-DR Antigens; Humans; Interferon-gamma; Leupeptins; Porphyromonas gingivalis; Proteins; Recombinant Proteins

1999
MHC class II antigen processing in B cells: accelerated intracellular targeting of antigens.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Jun-15, Volume: 162, Issue:12

    Topics: Animals; Antigen Presentation; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; beta-N-Acetylhexosaminidases; Binding Sites; Catalysis; Cell Compartmentation; Endocytosis; Histocompatibility Antigens Class II; Horseradish Peroxidase; Immune Sera; Intracellular Fluid; Leupeptins; Lysosomal Membrane Proteins; Lysosomes; Membrane Glycoproteins; Mice; Microscopy, Immunoelectron; Peptides; Pinocytosis; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Receptors, Transferrin; Subcellular Fractions; Tumor Cells, Cultured

1999
Involvement of interleukin-1beta in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120-induced apoptosis in the neocortex of rat.
    Neuroscience, 1999, Volume: 89, Issue:4

    Topics: Animals; Apoptosis; Body Temperature; Cattle; Citrulline; Gene Expression Regulation; HIV Envelope Protein gp120; Humans; In Situ Nick-End Labeling; Injections, Intraventricular; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Kinetics; Leupeptins; Male; Microglia; Neocortex; Rats; Rats, Wistar; Recombinant Proteins; Serum Albumin, Bovine; Sialoglycoproteins; Time Factors

1999
Expression of cathepsin B-like enzyme activity in cell lysate from cultured human normal keratinocytes.
    Human cell, 1998, Volume: 11, Issue:4

    Topics: Benzoylarginine-2-Naphthylamide; Cathepsin B; Cells, Cultured; Child; Cysteine Proteinase Inhibitors; Humans; Hydrolysis; Keratinocytes; Leupeptins; Male

1998
Functional early endosomes are required for maturation of major histocompatibility complex class II molecules in human B lymphoblastoid cells.
    The Journal of biological chemistry, 1999, Jun-18, Volume: 274, Issue:25

    Topics: Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Line; Endosomes; Histocompatibility Antigens Class II; Horseradish Peroxidase; Humans; Leupeptins; Lysosomes; Microscopy, Fluorescence; Peroxidases; Precipitin Tests; Transferrin

1999
Colocalization and membrane association of murine hepatitis virus gene 1 products and De novo-synthesized viral RNA in infected cells.
    Journal of virology, 1999, Volume: 73, Issue:7

    Topics: Animals; Cell Line; Cell Membrane Permeability; Chlorides; Cysteine Proteinase Inhibitors; DNA-Directed RNA Polymerases; HeLa Cells; Humans; Intracellular Membranes; Leucine; Leupeptins; Mice; Murine hepatitis virus; Rabbits; RNA, Viral; Staining and Labeling; Time Factors; Viral Proteins; Zinc Compounds

1999
The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.
    Nature medicine, 1999, Volume: 5, Issue:6

    Topics: Anemia, Megaloblastic; Animals; Antibodies; Apolipoprotein A-I; Case-Control Studies; Chloroquine; Chromatography, Affinity; Dog Diseases; Dogs; Endocytosis; Epithelial Cells; Female; Humans; Iodine Radioisotopes; Kidney; Leupeptins; Lipoproteins, HDL; Malabsorption Syndromes; Male; Rats; Rats, Wistar; Receptors, Cell Surface; Reference Values; Syndrome; Vitamin B 12 Deficiency; Yolk Sac

1999
Lipofuscin turnover.
    Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:8

    Topics: Animals; Cysteine Proteinase Inhibitors; Inclusion Bodies; Injections; Leupeptins; Lipofuscin; Pigment Epithelium of Eye; Rats

1999
Enzymatic modulation of cell volume in C6 glioma cells.
    Glia, 1999, Volume: 27, Issue:1

    Topics: Brain Neoplasms; Cell Size; Collagenases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glioma; Humans; Ion Channels; Leupeptins; Matrix Metalloproteinase 9; Mechanoreceptors; Peptide Hydrolases; Tumor Cells, Cultured

1999
Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Aug-01, Volume: 163, Issue:3

    Topics: Antigen Presentation; Antigen-Presenting Cells; B-Lymphocytes; Cell Line, Transformed; Cell Lineage; Epitopes, T-Lymphocyte; Glutamate Decarboxylase; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Leupeptins; Lymphocyte Activation; Pepstatins; Protease Inhibitors; Transfection

1999
Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin.
    Cell death and differentiation, 1999, Volume: 6, Issue:8

    Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Female; Humans; Leupeptins; Necrosis; Sphingosine; Tumor Cells, Cultured; U937 Cells

1999
Stabilizing neuromuscular contacts reduces motoneuron death caused by paralysis of muscles in neonatal rats.
    Neuroscience, 1999, Volume: 93, Issue:3

    Topics: Animals; Animals, Newborn; Bungarotoxins; Calpain; Cell Count; Cell Survival; Cholinergic Antagonists; Isometric Contraction; Leupeptins; Motor Neurons; Muscle, Skeletal; Neuromuscular Junction; Neurotoxins; Paralysis; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic

1999
Is lipofuscin eliminated from cells?
    Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:10

    Topics: Fibroblasts; Heart; Humans; Inclusion Bodies; Leupeptins; Lipofuscin; Myocardium; Pigment Epithelium of Eye

1999
A role for the proteasome in the light response of the timeless clock protein.
    Science (New York, N.Y.), 1999, Sep-10, Volume: 285, Issue:5434

    Topics: Acetylcysteine; Animals; Biological Clocks; Cells, Cultured; Circadian Rhythm; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Darkness; Drosophila; Drosophila Proteins; Feedback; Insect Proteins; Leucine; Leupeptins; Light; Multienzyme Complexes; Neurons; Phosphorylation; Phosphotyrosine; Protease Inhibitors; Proteasome Endopeptidase Complex; Ubiquitins

1999
Transgenic Arabidopsis leaf tissue expressing a modified oryzacystatin shows resistance to the field slug Deroceras reticulatum (Müller).
    Transgenic research, 1999, Volume: 8, Issue:2

    Topics: Animals; Arabidopsis; Cystatins; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Mollusca; Plant Leaves; Plants, Genetically Modified; Recombinant Proteins

1999
Effect of the selective and non-selective cysteine protease inhibitors on the intracellular processing of interleukin 6 by HEPG2 cells.
    In vitro cellular & developmental biology. Animal, 1999, Volume: 35, Issue:8

    Topics: Cathepsin B; Cathepsins; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Interleukin-6; Intracellular Fluid; Iodine Radioisotopes; Isotope Labeling; Ketones; Leucine; Leupeptins; Recombinant Proteins; Time Factors; Tumor Cells, Cultured

1999
Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition.
    Muscle & nerve, 2000, Volume: 23, Issue:1

    Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Histocytochemistry; Leupeptins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Microscopy, Electron; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Necrosis

2000
Binding and processing of (125)I-ACTH by isolated rat splenic lymphocytes.
    Biochemical and biophysical research communications, 1999, Dec-20, Volume: 266, Issue:2

    Topics: Adrenocorticotropic Hormone; Agouti Signaling Protein; alpha-MSH; Animals; Binding, Competitive; Endocytosis; Intercellular Signaling Peptides and Proteins; Iodine Radioisotopes; Leupeptins; Lymphocytes; Lysosomes; Male; Monensin; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin; Receptors, Melanocortin; Spleen; Temperature

1999
Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jan-15, Volume: 20, Issue:2

    Topics: Acetylcysteine; Animals; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Multienzyme Complexes; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Rats; Rats, Wistar; Ubiquitins

2000
Clathrin-coated lattices and buds on MHC class II compartments do not selectively recruit mature MHC-II.
    Journal of cell science, 2000, Volume: 113 Pt 2

    Topics: Antigens, Differentiation, B-Lymphocyte; Biological Transport, Active; Cell Compartmentation; Cell Line; Clathrin; Coated Pits, Cell-Membrane; Histocompatibility Antigens Class II; Humans; Leupeptins; Lysosomes; Microscopy, Immunoelectron

2000
Intracellular protein degradation and autophagy in isolated pancreatic acini of the rat.
    Cell biochemistry and function, 2000, Volume: 18, Issue:1

    Topics: Adenine; Amines; Amino Acids; Animals; Autophagy; Cells, Cultured; Enzyme Inhibitors; Kinetics; Leupeptins; Lysosomes; Male; Microscopy, Electron; Pancreas; Protein Biosynthesis; Proteins; Rats; Rats, Long-Evans; Vinblastine

2000
Identification of soluble forms of lectin-like oxidized LDL receptor-1.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:3

    Topics: Amino Acid Sequence; Animals; Aorta; Aprotinin; Arteriosclerosis; Biotinylation; Cattle; Cell Membrane; CHO Cells; Cricetinae; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Endopeptidases; Endothelium, Vascular; Glycoproteins; Lectins; Leupeptins; Lipoproteins, LDL; Membrane Proteins; Molecular Sequence Data; Pepstatins; Protease Inhibitors; Protein Structure, Tertiary; Receptors, LDL; Receptors, Oxidized LDL; Serine Proteinase Inhibitors; Solubility; Tosyl Compounds; Tosyllysine Chloromethyl Ketone; Tumor Necrosis Factor-alpha

2000
Accumulation and degradation in the endoplasmic reticulum of a truncated ER-60 devoid of C-terminal amino acid residues.
    Journal of biochemistry, 2000, Volume: 127, Issue:2

    Topics: Acetylcysteine; Animals; Calcium-Binding Proteins; Calnexin; Calreticulin; Carrier Proteins; Cell Membrane; COS Cells; Culture Media; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochalasin B; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Half-Life; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Proteins; Molecular Chaperones; Protein Disulfide-Isomerases; Recombinant Proteins; Ribonucleoproteins

2000
Suppression of endothelin-converting enzyme-1 during buccal mucosal ulcer healing: effect of chronic alcohol ingestion.
    Biochemical and biophysical research communications, 2000, May-10, Volume: 271, Issue:2

    Topics: Animals; Apoptosis; Aspartic Acid Endopeptidases; Edetic Acid; Endothelin-Converting Enzymes; Epithelial Cells; Ethanol; Leupeptins; Metalloendopeptidases; Mouth Mucosa; Oral Ulcer; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Time Factors; Tosyl Compounds; Tumor Necrosis Factor-alpha; Up-Regulation; Wound Healing

2000
Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation.
    Journal of immunology (Baltimore, Md. : 1950), 2000, May-15, Volume: 164, Issue:10

    Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line, Transformed; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epitopes, T-Lymphocyte; Hepatitis B e Antigens; Histocompatibility Antigens Class I; HIV Envelope Protein gp160; HIV-1; Humans; Hydrolysis; Leupeptins; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Pepstatins; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes, Cytotoxic

2000
Effect of protease inhibitors on angiotensin-converting enzyme activity in human T-lymphocytes.
    American journal of hypertension, 2000, Volume: 13, Issue:5 Pt 1

    Topics: Adult; Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Calpain; Captopril; Cathepsins; Chymotrypsin; Cysteine Proteinase Inhibitors; Humans; Leucine; Leupeptins; Lisinopril; Lymphocyte Activation; Male; Oligopeptides; Peptidyl-Dipeptidase A; Protease Inhibitors; T-Lymphocytes

2000
Suppression of autophagy by ethionine administration in male rat liver in vivo.
    Toxicology, 2000, May-19, Volume: 147, Issue:1

    Topics: Adenine; Adenosine Triphosphate; Animals; Antimetabolites; Centrifugation, Density Gradient; Cysteine Proteinase Inhibitors; Cytosol; Ethionine; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Male; Phagosomes; Rats; Rats, Wistar

2000
Performance of small-scale CHO perfusion cultures using an acoustic cell filtration device for cell retention: characterization of separation efficiency and impact of perfusion on product quality.
    Biotechnology and bioengineering, 2000, Aug-20, Volume: 69, Issue:4

    Topics: Acoustics; Animals; Blotting, Western; Cell Culture Techniques; Cell Survival; CHO Cells; Cricetinae; Filtration; Leupeptins; Macaca mulatta; Perfusion; Tissue Plasminogen Activator

2000
The mitogenic activity of fibroblast growth factor-1 correlates with its internalization and limited proteolytic processing.
    Journal of cellular physiology, 2000, Volume: 184, Issue:2

    Topics: 3T3 Cells; Animals; Antiviral Agents; Cell Nucleus; Chlorpromazine; Cysteine Proteinase Inhibitors; Cytoplasm; Cytosol; Dopamine Antagonists; Endocytosis; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Filipin; Humans; Leupeptins; Ligands; Mice; Mitogens; Signal Transduction

2000
Involvement of cysteine proteases in bFGF-induced angiogenesis in guinea pig and rat cornea.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:3

    Topics: Albumins; Animals; Cornea; Corneal Neovascularization; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Delayed-Action Preparations; Dipeptides; Eye Proteins; Fibroblast Growth Factor 2; Guinea Pigs; Leupeptins; Male; Organ Size; Rats

2000
Fibroblast growth factors are translocated to the nucleus of human endothelial cells in a microtubule- and lysosome-independent pathway.
    Biochemical and biophysical research communications, 2000, Jul-05, Volume: 273, Issue:2

    Topics: Biological Transport, Active; Cell Nucleus; Cells, Cultured; Chloroquine; Colchicine; Cytosol; Endothelium, Vascular; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Fibroblast Growth Factors; Humans; Kinetics; Leupeptins; Lysosomes; Microtubules; Subcellular Fractions

2000
Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Jul-18, Volume: 97, Issue:15

    Topics: Animals; Aprotinin; Atrial Natriuretic Factor; Benzamidines; Catalysis; Cell Line; COS Cells; Cricetinae; Gene Expression; Humans; Leupeptins; Membrane Proteins; Protein Precursors; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Structure-Activity Relationship; Trypsin Inhibitors

2000
Increased activity of calcium leak channels caused by proteolysis near sarcolemmal ruptures.
    The Journal of membrane biology, 2000, Jul-15, Volume: 176, Issue:2

    Topics: Animals; Calcium Channels; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leupeptins; Mice; Muscle, Skeletal; Sarcolemma

2000
Subtilisin increases macromolecular efflux from the oral mucosa.
    Clinical and diagnostic laboratory immunology, 2000, Volume: 7, Issue:5

    Topics: Animals; Aprotinin; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Cricetinae; Cyclooxygenase Inhibitors; Cysteine Proteinase Inhibitors; Indomethacin; Leupeptins; Macromolecular Substances; Male; Mesocricetus; Mouth Mucosa; Neurokinin-1 Receptor Antagonists; Serine Proteinase Inhibitors; Subtilisin

2000
[Demonstration of secondary free radicals and the role of calpain in functional changes associated with the myocardial ischemia-reperfusion sequence].
    Archives des maladies du coeur et des vaisseaux, 2000, Volume: 93, Issue:8

    Topics: Animals; Antioxidants; Calcium-Binding Proteins; Calpain; Catalase; Cathepsins; Cyclic N-Oxides; Cysteine Proteinase Inhibitors; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Leupeptins; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrogen Oxides; Oxidative Stress; Phycocyanin; Rats; Rats, Wistar; Spin Labels; Superoxides; Time Factors

2000
Purification and characterization of subtilisin DJ-4 secreted by Bacillus sp. strain DJ-4 screened from Doen-Jang.
    Bioscience, biotechnology, and biochemistry, 2000, Volume: 64, Issue:8

    Topics: Bacillus; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Fermentation; Fibrinolysis; Food Analysis; Korea; Leupeptins; Molecular Weight; Subtilisins

2000
Changes in the Ca2+-activation characteristics of demembranated rat single muscle fibres after prolonged incubation at room temperature in the presence and absence of DTT and protease inhibitors.
    Pflugers Archiv : European journal of physiology, 2000, Volume: 440, Issue:5

    Topics: Adenosine Triphosphatases; Animals; Calcium; Dithiothreitol; Histological Techniques; Leupeptins; Male; Muscle Contraction; Muscle Fibers, Skeletal; Myofibrils; Osmolar Concentration; Pepstatins; Protease Inhibitors; Rats; Rats, Long-Evans; Temperature; Time Factors

2000
Il-1-related cytokine responses of nonimmune skin cells subjected to CEES exposure with and without potential vesicant antagonists.
    In vitro & molecular toxicology, 2000,Summer, Volume: 13, Issue:2

    Topics: Benzimidazoles; Biomarkers; Calmodulin; Cells, Cultured; Cysteine Proteinase Inhibitors; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Irritants; Keratinocytes; Leupeptins; Mustard Gas; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Receptors, Interleukin-1; Receptors, Interleukin-1 Type II; Sialoglycoproteins

2000
[Modulation of T-cell-mediated immune responses by trichosanthin via antigen processing and presentation].
    Shi yan sheng wu xue bao, 1997, Volume: 30, Issue:2

    Topics: Antigen Presentation; Antigen-Presenting Cells; Cell Division; Chloroquine; Humans; Leupeptins; T-Lymphocytes; Trichosanthin

1997
A sensitive method to assay the xanthine oxidase activity in primary cultures of cerebellar granule cells.
    Brain research. Brain research protocols, 2000, Volume: 6, Issue:1-2

    Topics: Animals; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Antagonists; Fluorometry; Glutamic Acid; Leupeptins; Neurons; Protease Inhibitors; Pterins; Rats; Rats, Wistar; Temperature; Xanthine Oxidase; Xanthopterin

2000
Inhibition of apoptosis in cultured porcine granulosa cells by inhibitors of caspase and serine protease activity.
    Theriogenology, 2000, Sep-15, Volume: 54, Issue:5

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Membrane; Cysteine Proteinase Inhibitors; DNA Fragmentation; Electrophoresis, Agar Gel; Estradiol; Female; Flow Cytometry; Granulosa Cells; Leucine; Leupeptins; Microscopy, Fluorescence; Phenylmethylsulfonyl Fluoride; Progesterone; Radioimmunoassay; Regression Analysis; Serine Proteinase Inhibitors; Swine; Tosylphenylalanyl Chloromethyl Ketone

2000
Role of calcium-dependent protease(s) in globulization of isolated rat lens cortical fiber cells.
    Investigative ophthalmology & visual science, 2001, Volume: 42, Issue:1

    Topics: Aniline Compounds; Animals; Calcium; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fluorescent Dyes; Lens Cortex, Crystalline; Leupeptins; Organelles; Rats; Rats, Sprague-Dawley; Time Factors; Xanthenes

2001
Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+).
    Free radical biology & medicine, 2001, Jan-01, Volume: 30, Issue:1

    Topics: Acridine Orange; Adenine; Animals; Aurothioglucose; Cadmium; Cell Death; Chloroquine; Copper; Endopeptidases; Enzyme Activation; Gentamicins; Leupeptins; Lipid Peroxidation; Liver; Lysosomes; Male; Methylamines; Monensin; Oxidation-Reduction; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2001
Mechanisms mediating Porphyromonas gingivalis gingipain RgpA-induced oral mucosa inflammation in vivo.
    Infection and immunity, 2001, Volume: 69, Issue:2

    Topics: Adhesins, Bacterial; Animals; Bradykinin; Capillary Permeability; Catalytic Domain; Cricetinae; Cysteine Endopeptidases; Gingipain Cysteine Endopeptidases; Hemagglutinins; Indomethacin; Leupeptins; Male; Mesocricetus; Mouth Mucosa; Periodontitis; Receptor, Bradykinin B2; Receptors, Bradykinin

2001
Leupeptin-induced appearance of partial fragment of betaine homocysteine methyltransferase during autophagic maturation in rat hepatocytes.
    Journal of biochemistry, 2001, Volume: 129, Issue:2

    Topics: Animals; Autophagy; Betaine-Homocysteine S-Methyltransferase; Chloroquine; Cytosol; Hepatocytes; In Vitro Techniques; Leupeptins; Lysosomes; Male; Methyltransferases; Molecular Probes; Peptide Fragments; Proton-Translocating ATPases; Rats; Rats, Wistar; Vacuolar Proton-Translocating ATPases

2001
Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease.
    Infection and immunity, 2001, Volume: 69, Issue:3

    Topics: Adhesins, Bacterial; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Gingipain Cysteine Endopeptidases; Hemagglutinins; Histatins; Leupeptins; Matrix Metalloproteinase Inhibitors; Periodontal Diseases; Protease Inhibitors; Salivary Proteins and Peptides

2001
MHC class II presentation of endogenous tumor antigen by cellular vaccines depends on the endocytic pathway but not H2-M.
    Traffic (Copenhagen, Denmark), 2000, Volume: 1, Issue:2

    Topics: Acetylcysteine; Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Neoplasm; Antimalarials; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Coculture Techniques; Cysteine Proteinase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Endocytosis; Endoplasmic Reticulum; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Genes, MHC Class II; Humans; Hybridomas; Leupeptins; Major Histocompatibility Complex; Mice; Muramidase; Plasmids; Primaquine; Protein Synthesis Inhibitors; Protein Transport; Ribonucleases; Transfection; Tumor Cells, Cultured

2000
Salivary histatin 5 is a potent competitive inhibitor of the cysteine proteinase clostripain.
    FEBS letters, 2001, Jan-26, Volume: 489, Issue:1

    Topics: Amino Acid Sequence; Binding, Competitive; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Histatins; Humans; Kinetics; Leupeptins; Molecular Sequence Data; Salivary Glands; Salivary Proteins and Peptides

2001
Suppression of gingival inflammation induced by Porphyromonas gingivalis in rats by leupeptin.
    Japanese journal of pharmacology, 2001, Volume: 85, Issue:1

    Topics: Adhesins, Bacterial; Animals; Bacteroidaceae Infections; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Disease Progression; Gingipain Cysteine Endopeptidases; Gingivitis; Hemagglutinins; Leupeptins; Male; Maxilla; Porphyromonas gingivalis; Rats; Rats, Wistar; Virulence

2001
Association between bcl-x(L) and 5-lipoxygenase activating protein (FLAP) levels in IL-3-dependent FL5.12 cells.
    Toxicology, 2001, Mar-07, Volume: 160, Issue:1-3

    Topics: 5-Lipoxygenase-Activating Proteins; bcl-X Protein; Blotting, Northern; Blotting, Western; Carrier Proteins; Caspase Inhibitors; Cells, Cultured; Cloning, Molecular; Enzyme Inhibitors; Hematopoietic Stem Cells; Interleukin-3; Leupeptins; Membrane Proteins; Pepstatins; Phenylmethylsulfonyl Fluoride; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Transfection

2001
Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome.
    Journal of immunology (Baltimore, Md. : 1950), 2001, May-01, Volume: 166, Issue:9

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Aprotinin; Autoantigens; Carrier Proteins; Caspases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Herpesvirus 4, Human; Humans; Hydrolysis; Leucine; Leupeptins; Microfilament Proteins; Molecular Weight; Organ Specificity; Pepstatins; Sjogren's Syndrome; Trans-Activators; Tumor Cells, Cultured; Viral Proteins; Virus Activation

2001
Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells.
    BioTechniques, 2001, Volume: 30, Issue:4

    Topics: Animals; Baculoviridae; Cell Line; Cysteine Proteinase Inhibitors; Genetic Vectors; Insecta; Leucine; Leupeptins; Recombinant Proteins; Transfection

2001
Kinetic and structural properties of two isoforms of trypsin isolated from the viscera of Japanese anchovy, Engraulis japonicus.
    Journal of protein chemistry, 2001, Volume: 20, Issue:1

    Topics: Amino Acid Sequence; Animals; Antipain; Arginine; Benzoylarginine Nitroanilide; Enzyme Stability; Fishes; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Leupeptins; Molecular Sequence Data; Molecular Weight; Trypsin; Trypsin Inhibitors; Viscera

2001
Biogenesis of lysosomes in marshall cells and in cells of the male reproductive system.
    Molecular reproduction and development, 2001, Volume: 59, Issue:1

    Topics: Ammonium Chloride; Animals; Cathepsin B; Cell Line; Cysteine Proteinase Inhibitors; Endocytosis; Endosomes; Epididymis; Ferritins; Fibroblasts; Glycoproteins; Humans; Immunohistochemistry; Intracellular Membranes; Leupeptins; Lysosomes; Male; Mice; Mice, Transgenic; Sandhoff Disease; Saposins; Tay-Sachs Disease; Testis

2001
NO donors inhibit Leishmania infantum cysteine proteinase activity.
    Biochimica et biophysica acta, 2001, Feb-09, Volume: 1545, Issue:1-2

    Topics: Animals; Ascorbic Acid; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dithiothreitol; Glutathione; Kinetics; Leishmania infantum; Leupeptins; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitroglycerin; Nitroprusside; Nitroso Compounds; Penicillamine; Protozoan Proteins; S-Nitrosoglutathione

2001
Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments.
    Molecular biology of the cell, 2001, Volume: 12, Issue:5

    Topics: Acetylcysteine; Antimalarials; Cell Line; Chloroquine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endocytosis; Humans; Immunoblotting; Leupeptins; Microscopy, Fluorescence; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Sorting Signals; Protein Subunits; Receptors, Interleukin-2; Recombinant Fusion Proteins; Transfection; Ubiquitins

2001
Heat-induced proteasomic degradation of HSF1 in serum-starved human fibroblasts aging in vitro.
    Experimental cell research, 2001, Jul-15, Volume: 267, Issue:2

    Topics: Cells, Cultured; Cellular Senescence; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Female; Fibroblasts; Heat Shock Transcription Factors; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Binding; Transcription Factors

2001
Studies on the aminopeptidase activities of Porphyromonas gingivalis.
    Oral microbiology and immunology, 2001, Volume: 16, Issue:4

    Topics: Adhesins, Bacterial; Aminopeptidases; Anti-Bacterial Agents; Carbon Radioisotopes; Cathepsins; Chromogenic Compounds; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptidyl Peptidase 4; Gingipain Cysteine Endopeptidases; Guanidines; Hemagglutinins; Humans; Hydroxamic Acids; Leucine; Leupeptins; Mutation; Oligopeptides; Peptides; Porphyromonas gingivalis; Protease Inhibitors; Radiopharmaceuticals

2001
Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway.
    Biochemical and biophysical research communications, 2001, Jul-20, Volume: 285, Issue:3

    Topics: Acetylcysteine; Adenine; Alcohol Dehydrogenase; Animals; Calpain; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Electrophoresis, Polyacrylamide Gel; Hepatocytes; Leupeptins; Liver; Lysosomes; Male; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitins

2001
Calcium regulation of lysosomal proteolysis in skeletal muscle.
    Annals of the New York Academy of Sciences, 1986, Volume: 463

    Topics: Animals; Calcimycin; Calcium; Calmodulin; Dopamine Antagonists; Female; Insulin; Ionophores; Leupeptins; Lysosomes; Methylamines; Muscle Proteins; Muscle, Skeletal; Protease Inhibitors; Rats; Trifluoperazine

1986
Electrostatic recognition between enzyme and inhibitor: interaction between papain and leupeptin.
    Archives of biochemistry and biophysics, 2001, Oct-15, Volume: 394, Issue:2

    Topics: Binding Sites; Computer Simulation; Cysteine Proteinase Inhibitors; Leupeptins; Macromolecular Substances; Models, Chemical; Models, Molecular; Papain; Protein Binding; Static Electricity

2001
Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : understanding the basis of differential inhibition and the role of water.
    BMC structural biology, 2001, Volume: 1

    Topics: Amino Acid Chloromethyl Ketones; Binding Sites; Chymopapain; Computer Simulation; Cysteine Endopeptidases; Leupeptins; Macromolecular Substances; Plant Proteins; Plants; Protease Inhibitors; Protein Binding; Water

2001
Coaggregation of Porphyromonas gingivalis and Prevotella intermedia.
    Microbiology and immunology, 2001, Volume: 45, Issue:9

    Topics: Adhesins, Bacterial; alpha-Amylases; Arginine; Bacterial Adhesion; Bacterial Proteins; Cysteine Endopeptidases; Endopeptidase K; Fimbriae Proteins; Gingipain Cysteine Endopeptidases; Hemagglutinins; Hot Temperature; Humans; Lectins; Leupeptins; Lysine; Mutation; Plant Proteins; Porphyromonas gingivalis; Prevotella intermedia; Tosyllysine Chloromethyl Ketone; Trypsin Inhibitors

2001
Human muscle protein degradation in vitro by eosinophil cationic protein (ECP).
    Muscle & nerve, 2001, Volume: 24, Issue:12

    Topics: Actinin; Blood Proteins; Cysteine Proteinase Inhibitors; Cytoskeleton; Dose-Response Relationship, Drug; Dystrophin; Eosinophil Granule Proteins; Eosinophils; Fibrinolytic Agents; Heparin; Humans; In Vitro Techniques; Inflammation Mediators; Leupeptins; Muscle Proteins; Myofibrils; Myosin Heavy Chains; Myositis; Pepstatins; Protease Inhibitors; Ribonucleases; Sarcoplasmic Reticulum; Spectrin; Zinc

2001
Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria.
    Cell death and differentiation, 2001, Volume: 8, Issue:12

    Topics: Animals; Apoptosis; Calcium; Caspase 3; Caspases; Cysteine Endopeptidases; Death Domain Receptor Signaling Adaptor Proteins; DNA-Binding Proteins; Erythrocytes; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Macrophage Activation; Mice; Mitochondria; Models, Biological; Oligopeptides

2001
Internalization and stepwise degradation of heparan sulfate proteoglycans in rat hepatocytes.
    Biochimica et biophysica acta, 2001, Dec-19, Volume: 1541, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Biological Transport; Chromatography, Gel; Enzyme Inhibitors; Heparan Sulfate Proteoglycans; Hepatocytes; Leupeptins; Lysosomes; Macrolides; Male; Rats; Subcellular Fractions; Sulfur Radioisotopes; Temperature; Tritium; Vinblastine

2001
Characterization of an important enzymatic component in collagenase that is essential for the effective digestion of the human and porcine pancreas.
    Cell transplantation, 2001, Volume: 10, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Cell Separation; Clostridium; Cysteine Proteinase Inhibitors; Enzyme Stability; Epitopes; Humans; Islets of Langerhans; Islets of Langerhans Transplantation; Leupeptins; Mice; Mice, Inbred BALB C; Microbial Collagenase; Molecular Weight; Pancreas; Swine

2001
Inhibition of mu and delta opioid receptor ligand binding by the peptide aldehyde protease inhibitor, leupeptin.
    Regulatory peptides, 2002, Apr-15, Volume: 105, Issue:1

    Topics: Benzomorphans; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Ligands; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2002
Aggregation of human platelets by gingipain-R from Porphyromonas gingivalis cells and membrane vesicles.
    Platelets, 2002, Volume: 13, Issue:1

    Topics: Adhesins, Bacterial; Antithrombin III; Arginine; Blood Platelets; Cell Membrane; Chromatography; Cysteine; Cysteine Endopeptidases; Gingipain Cysteine Endopeptidases; Hemagglutinins; Humans; Leupeptins; Platelet Aggregation; Porphyromonas gingivalis

2002
Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity.
    Hearing research, 2002, Volume: 164, Issue:1-2

    Topics: Animals; Anti-Bacterial Agents; Calpain; Cochlea; Dose-Response Relationship, Drug; Gentamicins; Hair Cells, Auditory; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Leupeptins; Mice; Microscopy, Electron; Organ Culture Techniques; Saccule and Utricle; Semicircular Canals; Vestibule, Labyrinth

2002
Opening of ligand-gated cation channel families by calpain inhibitors.
    FEBS letters, 2002, Apr-24, Volume: 517, Issue:1-3

    Topics: Amino Acid Sequence; Animals; Calcium; Calcium Channels; Calcium-Binding Proteins; Calpain; Cell Membrane Permeability; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine Proteinase Inhibitors; Electrophysiology; Ion Channel Gating; Leupeptins; Ligands; Membrane Proteins; Molecular Sequence Data; Patch-Clamp Techniques; Receptors, Drug; Transfection; TRPP Cation Channels

2002
Complexity of agonist- and cyclic AMP-mediated downregulation of the human beta 1-adrenergic receptor: role of internalization, degradation, and mRNA destabilization.
    Biochemistry, 2002, Jun-25, Volume: 41, Issue:25

    Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Cricetinae; Cyclic AMP; Down-Regulation; Humans; Isoproterenol; Leupeptins; Molecular Sequence Data; Pepstatins; Protease Inhibitors; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; RNA Stability; RNA, Messenger; Thionucleotides

2002
Stage-specific antimalarial activity of cysteine protease inhibitors.
    Biological chemistry, 2002, Volume: 383, Issue:5

    Topics: Animals; Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Gene Expression Regulation, Developmental; Hemoglobins; Hydrolysis; Leucine; Leupeptins; Plasmodium falciparum; Time Factors

2002
Natural killer-like cells in the sheep: functional characterization and regulation by pregnancy-associated proteins.
    Experimental biology and medicine (Maywood, N.J.), 2002, Volume: 227, Issue:9

    Topics: Animals; Antibodies, Monoclonal; Dogs; Endometrium; Epithelial Cells; Female; Humans; Interferon Type I; Killer Cells, Natural; Leupeptins; Lymphocytes; Membrane Glycoproteins; Membrane Proteins; Pepstatins; Perforin; Pore Forming Cytotoxic Proteins; Pregnancy; Pregnancy Proteins; Protease Inhibitors; Serpins; Sheep; Tumor Cells, Cultured

2002
Involvement of proteases in the action of IFN-gamma on WISH cells.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2002, Volume: 22, Issue:8

    Topics: Amnion; Cell Division; Cell Line; Cell Membrane; DNA Replication; Humans; Interferon-gamma; Leupeptins; Lysine; Pepstatins; Phenylalanine; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors; Subcellular Fractions; Thiorphan; Tosyllysine Chloromethyl Ketone; Trypsin Inhibitor, Bowman-Birk Soybean

2002
Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor.
    Infection and immunity, 2002, Volume: 70, Issue:12

    Topics: Adhesins, Bacterial; Animals; Bacteroidaceae Infections; Cysteine Endopeptidases; Disease Models, Animal; Gingipain Cysteine Endopeptidases; Hemagglutinins; Hemolysis; Humans; Leupeptins; Mice; Mice, Inbred BALB C; Mutation; Pigments, Biological; Porphyromonas gingivalis; Protease Inhibitors; Virulence

2002
Impact of cysteine proteinase inhibition in midgut fluid and oral secretion on fecundity and pollen consumption of western corn rootworm (Diabrotica virgifera virgifera).
    Archives of insect biochemistry and physiology, 2003, Volume: 52, Issue:3

    Topics: Animals; Coleoptera; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Digestive System; Eating; Female; Fertility; Leucine; Leupeptins; Male; Oligopeptides; Pollen; Zea mays

2003
Involvement of cysteine proteinases in excystment of Paragonimus ohirai metacercariae induced by sodium cholate and A23187.
    Journal of helminthology, 2003, Volume: 77, Issue:1

    Topics: Animals; Calcimycin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Ionophores; Leucine; Leupeptins; Paragonimus; Parasitology; Reproduction; Serine Proteinase Inhibitors; Sodium Cholate

2003
Expression, purification, and inhibition of in vitro proteolysis of human AMPD2 (isoform L) recombinant enzymes.
    Protein expression and purification, 2003, Volume: 27, Issue:2

    Topics: AMP Deaminase; Baculoviridae; Blotting, Western; Chromatography, Gel; Cross-Linking Reagents; Dimerization; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; Humans; Leupeptins; Peptides; Plasmids; Precipitin Tests; Protein Isoforms; Protein Structure, Tertiary; Recombinant Fusion Proteins; Recombinant Proteins; Temperature; Transfection

2003
The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Mar-18, Volume: 100, Issue:6

    Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; HIV; HIV Infections; Humans; In Vitro Techniques; Leupeptins; Protease Inhibitors; Virus Replication

2003
Neuroprotection of vestibular sensory cells from gentamicin ototoxicity obtained using nitric oxide synthase inhibitors, reactive oxygen species scavengers, brain-derived neurotrophic factors and calpain inhibitors.
    Acta oto-laryngologica, 2003, Volume: 123, Issue:1

    Topics: Animals; Brain-Derived Neurotrophic Factor; Calpain; Cell Survival; Free Radical Scavengers; Gentamicins; Guinea Pigs; Hair Cells, Vestibular; In Vitro Techniques; Leupeptins; Methionine; Microscopy, Fluorescence; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Reactive Oxygen Species

2003
In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1.
    Cellular and molecular biology (Noisy-le-Grand, France), 2002, Volume: 48 Online Pub

    Topics: Antioxidants; Calpain; Electron Spin Resonance Spectroscopy; Glycoproteins; Kinetics; Leupeptins; Phycocyanin

2002
Calpain-mediated AQP2 proteolysis in inner medullary collecting duct.
    Biochemical and biophysical research communications, 2003, Mar-28, Volume: 303, Issue:1

    Topics: Animals; Aquaporin 2; Aquaporin 6; Aquaporins; Calcium; Calcium-Binding Proteins; Calpain; Caseins; Cysteine Proteinase Inhibitors; Dextrans; Dihydrotachysterol; Dose-Response Relationship, Drug; Down-Regulation; Endosomes; Flow Cytometry; Immunoblotting; Immunohistochemistry; Kidney Tubules, Collecting; Leupeptins; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Trypsin

2003
Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditions.
    The international journal of biochemistry & cell biology, 2003, Volume: 35, Issue:5

    Topics: Autophagy; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fibroblasts; Humans; Hydrolysis; Kinetics; Lactones; Leupeptins; Lysosomes; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; Scintillation Counting

2003
A nonintrinsic regional basis for increased infrarenal aortic MMP-9 expression and activity.
    Journal of vascular surgery, 2003, Volume: 37, Issue:5

    Topics: Actins; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Blood Pressure; Chelating Agents; Disease Models, Animal; Edetic Acid; Gelatin; Gelatinases; Heart Rate; Leupeptins; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Models, Cardiovascular; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1

2003
Endostatin induces autophagic cell death in EAhy926 human endothelial cells.
    Histology and histopathology, 2003, Volume: 18, Issue:3

    Topics: Acridine Orange; Adenine; Animals; Antineoplastic Agents; Apoptosis; Aprotinin; Blotting, Western; Caspases; Cell Death; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Endostatins; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Flow Cytometry; Glutathione Transferase; Humans; Immunohistochemistry; Leupeptins; Lysosomes; Microscopy, Electron; Microscopy, Phase-Contrast; Oxidative Stress; Reactive Oxygen Species; Recombinant Proteins; Serine; Time Factors

2003
Intracellular expression of CD69 in endometrial and peripheral T cells represents a useful marker in women with recurrent miscarriage: modulation after allogeneic leukocyte immunotherapy.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2003, Volume: 49, Issue:3

    Topics: Abortion, Habitual; Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Biomarkers; CD3 Complex; Cysteine Proteinase Inhibitors; Cytokines; Endometrium; Female; Flow Cytometry; Follow-Up Studies; Humans; Immunophenotyping; Immunotherapy; Lectins, C-Type; Leupeptins; Lymphocyte Activation; Lymphocyte Transfusion; Male; Pregnancy; T-Lymphocyte Subsets; T-Lymphocytes; Transplantation, Homologous

2003
Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity.
    Acta oto-laryngologica, 2003, Volume: 123, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Calpain; Caspase Inhibitors; Cathepsins; Cysteine Proteinase Inhibitors; Gentamicins; Guinea Pigs; Hair Cells, Vestibular; Leupeptins; Oligopeptides; Organ Culture Techniques; Pilot Projects

2003
Differential DNA synthesis in response to activation of protease-activated receptors on cultured guinea-pig tracheal smooth muscle cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 368, Issue:1

    Topics: Actins; Animals; Cell Division; Cells, Cultured; DNA; Guinea Pigs; Humans; Leupeptins; Muscle, Smooth; Peptides; Protease Inhibitors; Receptor, PAR-1; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Thrombin; Thymidine; Trachea; Tryptases

2003
Increase in epidermal growth factor receptor protein induced in osteoblastic cells after exposure to flow of culture media.
    American journal of physiology. Cell physiology, 2003, Volume: 285, Issue:2

    Topics: Bone and Bones; Bone Development; Culture Media, Conditioned; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Leupeptins; Osteoblasts; Peptide Hydrolases; Physical Stimulation; Protease Inhibitors; Protein Transport; Signal Transduction; Stress, Mechanical; Tumor Cells, Cultured; Up-Regulation

2003
The calpain-calpastatin system and the calcium paradox in the isolated perfused pigeon heart.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2003, Volume: 13, Issue:3

    Topics: Animals; Antipain; Barium; Calcium; Calcium-Binding Proteins; Calpain; Cobalt; Columbidae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylmaleimide; Heart; In Vitro Techniques; Kinetics; Leucine; Leupeptins; Magnesium; Manganese; Molecular Weight; Myocardium; Nickel; Phenylmethylsulfonyl Fluoride; Strontium; Time Factors

2003
Characterization of a new p94-like calpain form in human lymphocytes.
    The Biochemical journal, 2003, Nov-01, Volume: 375, Issue:Pt 3

    Topics: Calcium; Calpain; Catalysis; Cloning, Molecular; Cysteine Proteinase Inhibitors; DNA, Complementary; Enzyme Activation; Erythrocytes; Humans; Immunoblotting; Isoenzymes; Leupeptins; Lymphocytes; Neutrophils; Sequence Analysis, DNA

2003
Calpain-2 as a target for limiting prostate cancer invasion.
    Cancer research, 2003, Aug-01, Volume: 63, Issue:15

    Topics: Animals; Calpain; Cell Movement; Cysteine Proteinase Inhibitors; Down-Regulation; ErbB Receptors; Glycoproteins; Humans; Leupeptins; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Oligonucleotides, Antisense; Prostatic Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2003
Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors.
    Acta pharmacologica Sinica, 2003, Volume: 24, Issue:9

    Topics: alpha 1-Antitrypsin; Chymases; Humans; Leupeptins; Lung; Mast Cells; Protease Inhibitors; Serine Endopeptidases; Skin; Tryptases

2003
Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells.
    American journal of respiratory cell and molecular biology, 2004, Volume: 30, Issue:4

    Topics: Amphiregulin; Aprotinin; Dose-Response Relationship, Drug; EGF Family of Proteins; Epithelial Cells; ErbB Receptors; Gene Expression Regulation; Glycoconjugates; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Leupeptins; Mucin 5AC; Mucin-2; Mucins; Protease Inhibitors; Quinazolines; Receptor, PAR-2; Respiratory Mucosa; Respiratory System; Serine Endopeptidases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrphostins

2004
Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2.
    The Journal of biological chemistry, 2004, Jan-30, Volume: 279, Issue:5

    Topics: Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; Cloning, Molecular; Cysteine Endopeptidases; Disulfides; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Immunoblotting; Kinetics; Leupeptins; Molecular Sequence Data; Plasmodium; Plasmodium falciparum; Protein Folding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Tyrosine

2004
Interaction of Porphyromonas gingivalis with low-density lipoproteins: implications for a role for periodontitis in atherosclerosis.
    Journal of periodontal research, 2004, Volume: 39, Issue:1

    Topics: Adhesins, Bacterial; Animals; Apolipoprotein B-100; Apolipoproteins B; Arteriosclerosis; Cell Line; Cell Membrane; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Foam Cells; Gingipain Cysteine Endopeptidases; Hemagglutinins; Humans; Leupeptins; Lipoproteins, LDL; Macrophages; Mice; Periodontitis; Porphyromonas gingivalis; Protein Synthesis Inhibitors; Tosyllysine Chloromethyl Ketone; Vacuoles

2004
Protease inhibitor leupeptin attenuates myocardial stunning in rat heart.
    Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10, Issue:1

    Topics: Animals; Blood Pressure; Calcium; Carbon Dioxide; Cardiac Output; Coronary Circulation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; In Vitro Techniques; Leupeptins; Male; Myocardial Contraction; Myocardial Stunning; Oxygen Consumption; Perfusion; Rats; Rats, Wistar

2004
Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organization.
    Experimental cell research, 2004, Jan-01, Volume: 292, Issue:1

    Topics: Animals; Calcium-Binding Proteins; Calpain; Cell Adhesion; Cell Fusion; Cell Line; Cell Movement; Clone Cells; Cysteine Proteinase Inhibitors; Cytoskeleton; Dipeptides; Dose-Response Relationship, Drug; Glucosidases; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Proteins; Mice; Muscle Fibers, Skeletal; Myoblasts; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides; Phosphoproteins; Stress Fibers

2004
The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma.
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 340, Issue:1-2

    Topics: Amino Acid Sequence; Antipain; Epitopes; Humans; Kallikreins; Leupeptins; Molecular Sequence Data; Natriuretic Peptide, Brain; Protease Inhibitors; Serine Proteinase Inhibitors; Substrate Specificity

2004
A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin.
    The Biochemical journal, 2004, May-01, Volume: 379, Issue:Pt 3

    Topics: Adhesins, Bacterial; Agar; Animals; Cysteine Endopeptidases; Gingipain Cysteine Endopeptidases; Hemagglutinins; Horses; Leupeptins; Oxyhemoglobins; Pigments, Biological; Porphyromonas gingivalis; Protoporphyrins; Spectrophotometry, Ultraviolet; Spectroscopy, Mossbauer; Spectrum Analysis, Raman; Time Factors

2004
Partial and delayed release of troponin-I compared with the release of lactate dehydrogenase from necrotic cardiomyocytes.
    Pflugers Archiv : European journal of physiology, 2004, Volume: 448, Issue:2

    Topics: Animals; Antimetabolites; Calpain; Cysteine Proteinase Inhibitors; Deoxyglucose; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; In Vitro Techniques; L-Lactate Dehydrogenase; Leupeptins; Male; Myocytes, Cardiac; Necrosis; Rats; Rats, Wistar; Sodium Cyanide; Troponin I

2004
Structural basis of the unusual stability and substrate specificity of ervatamin C, a plant cysteine protease from Ervatamia coronaria.
    Biochemistry, 2004, Feb-17, Volume: 43, Issue:6

    Topics: Amino Acid Sequence; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Stability; Evolution, Molecular; Leupeptins; Molecular Sequence Data; Papain; Plant Proteins; Protein Folding; Protein Structure, Tertiary; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Substrate Specificity; Tabernaemontana

2004
Calpain and caspase-3 inhibitors reduce infarct size and post-ischemic apoptosis in rat heart without modifying contractile recovery.
    Cellular and molecular biology (Noisy-le-Grand, France), 2003, Volume: 49 Online Pub

    Topics: Animals; Apoptosis; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Glycoproteins; Heart; Ischemia; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Muscle Contraction; Myocardium; Rats; Reperfusion

2003
Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration.
    Neuroscience, 2004, Volume: 125, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calpain; Cell Count; Cell Survival; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agents; Female; Immunohistochemistry; Isometric Contraction; Leupeptins; Male; Microtubule-Associated Proteins; Motor Neuron Disease; Motor Neurons; Muscle Fatigue; Muscle Fibers, Skeletal; Muscle, Skeletal; Myosins; Nerve Crush; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Spinal Cord; Staining and Labeling; Time Factors

2004
Sustained-release delivery of leupeptin in the chinchilla: hearing results.
    The international tinnitus journal, 2003, Volume: 9, Issue:2

    Topics: Animals; Auditory Threshold; Calpain; Chinchilla; Cysteine Proteinase Inhibitors; Delayed-Action Preparations; Dose-Response Relationship, Drug; Ear, Inner; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Leupeptins; Models, Animal; Perilymph; Time Factors

2003
Loss of lipopolysaccharide receptor CD14 from the surface of human macrophage-like cells mediated by Porphyromonas gingivalis outer membrane vesicles.
    Microbial pathogenesis, 2004, Volume: 36, Issue:6

    Topics: Adhesins, Bacterial; Blotting, Western; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Escherichia coli; Gingipain Cysteine Endopeptidases; Gingival Crevicular Fluid; Hemagglutinins; Humans; Leupeptins; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophages; Periodontitis; Porphyromonas gingivalis; Tumor Necrosis Factor-alpha; Virulence Factors

2004
[Effects of protease inhibitors on intestinal absorption of insulin].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2004, Volume: 39, Issue:2

    Topics: Animals; Bacitracin; Biological Availability; Blood Glucose; Colon; Glycocholic Acid; Insulin; Intestinal Absorption; Intestine, Small; Leupeptins; Male; Protease Inhibitors; Random Allocation; Rats; Rats, Wistar

2004
Calpain inhibitors improve myocardial dysfunction and inflammation induced by endotoxin in rats.
    Shock (Augusta, Ga.), 2004, Volume: 21, Issue:4

    Topics: Animals; Cardiomyopathies; Endotoxins; Glycoproteins; Heart; In Vitro Techniques; Inflammation; Injections, Intravenous; Leukocyte Rolling; Leupeptins; Male; Myocardial Contraction; Myocardium; Nitrates; Nitrites; Rats; Rats, Sprague-Dawley; Shock, Septic; Tumor Necrosis Factor-alpha

2004
The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic-reperfused heart.
    Journal of molecular and cellular cardiology, 2004, Volume: 37, Issue:1

    Topics: Animals; Blotting, Western; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Calpain; Calsequestrin; Cyclic AMP-Dependent Protein Kinases; Cytosol; Down-Regulation; Leupeptins; Male; Myocardial Contraction; Myocardium; Perfusion; Phosphorylation; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Time Factors

2004
Multiple cleavage sites for polymeric immunoglobulin receptor.
    Immunology, 2004, Volume: 112, Issue:4

    Topics: Animals; Cells, Cultured; Cricetinae; Endoplasmic Reticulum; Golgi Apparatus; Humans; Leupeptins; Mutagenesis, Site-Directed; Receptors, Polymeric Immunoglobulin; Secretory Component; Structure-Activity Relationship; Transfection; Vaccinia virus

2004
Myosin Va is proteolysed in rat cerebellar granule neurons after excitotoxic injury.
    Neuroscience letters, 2004, Sep-09, Volume: 367, Issue:3

    Topics: Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Cell Death; Cells, Cultured; Cerebellum; Cysteine Proteinase Inhibitors; Drug Interactions; Excitatory Amino Acids; Glycoproteins; Leupeptins; Myosin Heavy Chains; Myosin Type V; Neurons; Rats; Tetrazolium Salts; Thiazoles; Time Factors

2004
The function of a trypsin-like enzyme in the saliva of Euplectrus separatae larvae.
    Journal of insect physiology, 2004, Volume: 50, Issue:9

    Topics: Animals; Dose-Response Relationship, Drug; Endopeptidase Clp; Host-Parasite Interactions; Hyaluronoglucosaminidase; Larva; Leupeptins; Matrix Metalloproteinases; Moths; Phospholipases; Saliva; Spectrometry, Fluorescence; Trypsin; Trypsin Inhibitors; Wasps

2004
Substrate-dependent modulation of the mechanism of factor XIa inhibition.
    Biochemistry, 2004, Sep-21, Volume: 43, Issue:37

    Topics: Aprotinin; Binding Sites; Enzyme-Linked Immunosorbent Assay; Factor IX; Factor XIa; Leupeptins; Models, Biological; Protease Inhibitors

2004
Regulation of muscle Cav1.1 channels by long-term depolarization involves proteolysis of the alpha1s subunit.
    The Journal of membrane biology, 2004, Jun-01, Volume: 199, Issue:3

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Leupeptins; Membrane Potentials; Muscle, Skeletal; Patch-Clamp Techniques; Protease Inhibitors; Protein Subunits; Ranidae; RNA, Messenger

2004
Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site.
    Journal of molecular biology, 2004, Nov-05, Volume: 343, Issue:5

    Topics: Amino Acid Sequence; Animals; Calpain; Catalytic Domain; Cathepsin K; Cathepsins; Crystallization; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Glycoproteins; Leucine; Leupeptins; Molecular Sequence Data; Papain; Protein Structure, Tertiary; Rats

2004
Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis.
    The Journal of veterinary medical science, 2004, Volume: 66, Issue:10

    Topics: Animals; Antipain; Chromogenic Compounds; Escherichia coli; Fluorescent Dyes; Hydrogen-Ion Concentration; Ixodidae; Leucine; Leupeptins; Pepstatins; Phenylmethylsulfonyl Fluoride; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Temperature

2004
[Effect of tryptase inhibitors on histamine release from human colon mast cells].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2004, Volume: 20, Issue:6

    Topics: Cells, Cultured; Colon; Histamine Release; Humans; Lactoferrin; Leupeptins; Mast Cells; Protamines; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tryptases

2004
Transferrin-oligomers as potential carriers in anticancer drug delivery.
    Pharmaceutical research, 2004, Volume: 21, Issue:11

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Drug Carriers; Drug Delivery Systems; Endocytosis; Humans; Indicators and Reagents; Leupeptins; Methotrexate; Polymers; Receptors, Cell Surface; Receptors, Transferrin; Transferrin

2004
Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway.
    Biochemical and biophysical research communications, 2005, Apr-01, Volume: 329, Issue:1

    Topics: Animals; Binding Sites; Blotting, Northern; Blotting, Western; Cell Line; Cholera Toxin; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Enzyme Activation; Fibrinolysin; Flavonoids; Genes, Dominant; Humans; Immediate-Early Proteins; Leupeptins; Lysine; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Plasminogen; Protein Binding; Proto-Oncogene Proteins c-fos; RNA; RNA, Messenger; Serine Endopeptidases; Signal Transduction; Time Factors; Transcription Factors

2005
The interaction of human tryptase-beta with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease.
    Biochemistry, 2005, Mar-08, Volume: 44, Issue:9

    Topics: Aprotinin; Binding, Competitive; Chromatography, Gel; Enzyme Reactivators; Enzyme Stability; Humans; Hydrogen-Ion Concentration; Hydrolysis; Leupeptins; Protein Structure, Quaternary; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfones; Tryptases

2005
Schistosoma mansoni: functional proteasomes are required for development in the vertebrate host.
    Experimental parasitology, 2005, Volume: 109, Issue:4

    Topics: Adenosine Triphosphate; Animals; Biomphalaria; Coumarins; Host-Parasite Interactions; Hydrolysis; Leupeptins; Lung; Mice; Mice, Inbred BALB C; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Schistosoma mansoni; Schistosomiasis mansoni; Ubiquitin

2005
Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.
    The Journal of biological chemistry, 2005, May-13, Volume: 280, Issue:19

    Topics: Acetylcysteine; Alkaloids; Blotting, Western; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Cytosol; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Green Fluorescent Proteins; Humans; Immunoprecipitation; Leupeptins; Long QT Syndrome; Mutation; Potassium Channels; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ribonucleases; Subcellular Fractions; Time Factors; Transfection; Ubiquitin

2005
A cysteine-activated protease isolated from Todarodes pacificus squid degrades collagen below its denaturation temperature.
    Connective tissue research, 2004, Volume: 45, Issue:2

    Topics: Amino Acid Sequence; Animals; Cattle; Collagen; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Decapodiformes; Hydrogen-Ion Concentration; Leucine; Leupeptins; Molecular Sequence Data; Molecular Weight; Muscles; Octopodiformes; Protein Denaturation; Snails; Species Specificity; Temperature

2004
Induction of cell death in rat small intestine by ischemia reperfusion: differential roles of Fas/Fas ligand and Bcl-2/Bax systems depending upon cell types.
    Histochemistry and cell biology, 2005, Volume: 123, Issue:3

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase Inhibitors; Caspases; Cytochromes c; Fas Ligand Protein; Immunohistochemistry; In Situ Nick-End Labeling; Intestine, Small; Leupeptins; Membrane Glycoproteins; Microscopy, Electron; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reperfusion Injury

2005
Alpha-synuclein-positive structures induced in leupeptin-infused rats.
    Brain research, 2005, Apr-08, Volume: 1040, Issue:1-2

    Topics: alpha-Synuclein; Animals; Cysteine Proteinase Inhibitors; Fornix, Brain; Hippocampus; Infusion Pumps, Implantable; Injections, Intraventricular; Leupeptins; Nerve Tissue Proteins; Neurons; Rats; Rats, Wistar; Secretory Vesicles; Synucleins

2005
Testing the "garbage" accumulation theory of ageing: mitotic activity protects cells from death induced by inhibition of autophagy.
    Biogerontology, 2005, Volume: 6, Issue:1

    Topics: Adenine; Aging; Astrocytes; Autophagy; Cell Line; Cell Survival; Cellular Senescence; Cysteine Proteinase Inhibitors; Fibroblasts; Humans; Leupeptins; Mitosis; Phosphoinositide-3 Kinase Inhibitors

2005
Transient expression of polymeric immunoglobulin receptor in human adenocarcinoma cell line HT-29.
    Journal of oral science, 2005, Volume: 47, Issue:1

    Topics: Culture Media; Cysteine Proteinase Inhibitors; Enzyme-Linked Immunosorbent Assay; HT29 Cells; Humans; Immunoprecipitation; Leupeptins; Protein Kinase C; Protein Transport; Receptors, Polymeric Immunoglobulin; Secretory Component; Tetradecanoylphorbol Acetate; Transfection; Vaccinia virus

2005
B-domain deleted factor VIII is aggregated and degraded through proteasomal and lysosomal pathways.
    Thrombosis and haemostasis, 2005, Volume: 93, Issue:5

    Topics: Animals; Antigens, CD; Centrifugation, Density Gradient; CHO Cells; Cricetinae; Detergents; Factor VIII; Furin; Glycosylation; Immunoblotting; Immunoprecipitation; Leupeptins; Lysosomal Membrane Proteins; Lysosomes; Microscopy, Confocal; Microscopy, Fluorescence; Neuraminidase; Octoxynol; Peptide Fragments; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Sucrose; Transfection; Tunicamycin

2005
Leupeptin-sensitive proteases involved in cell survival after X-ray irradiation in human RSa cells.
    Cell biology international, 2005, Volume: 29, Issue:8

    Topics: Apoptosis; Blotting, Western; Cell Division; Cell Survival; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; Fibrinolysis; Flow Cytometry; G2 Phase; Humans; Leupeptins; Peptide Hydrolases; Radiation Tolerance; Tumor Cells, Cultured; X-Rays

2005
Plasmodium berghei: effect of protease inhibitors during gametogenesis and early zygote development.
    Experimental parasitology, 2005, Volume: 111, Issue:4

    Topics: Analysis of Variance; Animals; Gametogenesis; Leupeptins; Mice; Mice, Inbred BALB C; Phenanthrolines; Phenylmethylsulfonyl Fluoride; Plasmodium berghei; Protease Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Zygote

2005
Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 290, Issue:2

    Topics: Aged; Bronchi; Butadienes; Calcium; Cell Proliferation; Chromatography, Gel; DNA; Fibroblasts; Humans; Leupeptins; Lung; MAP Kinase Signaling System; Middle Aged; Nitriles; Receptor, PAR-2; Serine Endopeptidases; Sputum; Tryptases

2006
Arginine vasopressin transport and metabolism in the pigmented rabbit conjunctiva.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1998, Volume: 6, Issue:1

    Topics: Animals; Arginine Vasopressin; Biological Transport; Chromatography, High Pressure Liquid; Conjunctiva; Esters; Gabexate; Guanidines; In Vitro Techniques; Leupeptins; Male; Protease Inhibitors; Rabbits; Tritium

1998
Enzymatic measurement of tryptase-like protease release from isolated perfused guinea pig heart during ischemia-reperfusion.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:11

    Topics: Animals; Creatine Kinase; Cysteine Proteinase Inhibitors; Female; Guinea Pigs; Histamine Release; In Vitro Techniques; Leupeptins; Myocardial Reperfusion Injury; Myocardium; Serine Endopeptidases; Tryptases

2005
Tryptase increases proliferative activity of human conjunctival fibroblasts through protease-activated receptor-2.
    Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:12

    Topics: Benzamidines; Blotting, Western; Cell Proliferation; Cells, Cultured; Conjunctiva; Dose-Response Relationship, Drug; Fibroblasts; Humans; Immunoenzyme Techniques; Keratoconjunctivitis; Leupeptins; Mast Cells; Oligopeptides; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Serine Proteinase Inhibitors; Tryptases; Up-Regulation

2005
Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion.
    International journal for parasitology, 2006, Volume: 36, Issue:1

    Topics: Animals; Antibodies, Protozoan; Antipain; Cell Division; Cells, Cultured; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Flow Cytometry; Heteroptera; Immunohistochemistry; Iodoacetamide; Leucine; Leupeptins; Membrane Proteins; Microscopy, Electron; Octoxynol; Plant Proteins; Polyethylene Glycols; Protozoan Proteins; Salivary Glands; Trypanosomatina

2006
High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection.
    Analytical chemistry, 2005, Dec-15, Volume: 77, Issue:24

    Topics: Cathepsin B; Chromatography, Liquid; Dipeptides; Drug Stability; Hot Temperature; Leucine; Leupeptins; Online Systems; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tea

2005
Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice.
    European journal of pharmacology, 2006, Jan-13, Volume: 530, Issue:1-2

    Topics: Animals; Antibodies; Antipruritics; Benzamidines; Dose-Response Relationship, Drug; Extravasation of Diagnostic and Therapeutic Materials; Guanidines; Histamine; Histamine H1 Antagonists; Injections, Intradermal; Leupeptins; Male; Mast Cells; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Oligopeptides; p-Methoxy-N-methylphenethylamine; Pruritus; Receptor, PAR-2; Serine Endopeptidases; Serotonin; Skin; Terfenadine; Time Factors; Tryptases

2006
X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition.
    Journal of molecular biology, 2006, Mar-17, Volume: 357, Issue:1

    Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Humans; Isoenzymes; Leupeptins; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Quaternary; Recombinant Proteins; Sequence Alignment; Serine Endopeptidases; Tryptases

2006
Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities.
    Journal of immunology (Baltimore, Md. : 1950), 2006, Mar-15, Volume: 176, Issue:6

    Topics: Asthma; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Chemokines, CC; Chemotaxis; Eosinophils; Gene Expression Regulation; Humans; Leupeptins; Mast Cells; Recombinant Proteins; RNA, Messenger; Serine Endopeptidases; Tryptases

2006
Release of iron from ferritin requires lysosomal activity.
    American journal of physiology. Cell physiology, 2006, Volume: 291, Issue:3

    Topics: Animals; Caco-2 Cells; Chloroquine; Deferoxamine; Enterocytes; Erythroid Cells; Ferritins; Hepatocytes; Humans; Immunoelectrophoresis; Iron; K562 Cells; Leupeptins; Lysosomes; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Rats

2006
Remodeling of connexin 43 in the diabetic rat heart.
    Molecular and cellular biochemistry, 2006, Volume: 290, Issue:1-2

    Topics: Animals; Cell Communication; Connexin 43; Diabetes Mellitus, Experimental; Electrophysiology; Gap Junctions; Heart; Immunoblotting; Immunohistochemistry; Leupeptins; Male; Microscopy, Electron; Myocardium; Phosphorylation; Protein Isoforms; Protein Kinase C; Rats; Rats, Wistar; Streptozocin

2006
Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity.
    The Tohoku journal of experimental medicine, 2006, Volume: 209, Issue:2

    Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Apoptosis; Biomarkers; Calpain; Cell Survival; Cochlea; Dose-Response Relationship, Drug; Drug Antagonism; Hair Cells, Auditory, Inner; Leupeptins; Mice; Mice, Inbred C57BL; Neomycin; Organ Culture Techniques; Phalloidine; Protein Synthesis Inhibitors

2006
Calpain inhibitors delay injury-induced apoptosis in adult mouse spinal cord motor neurons.
    Neuroreport, 2006, May-29, Volume: 17, Issue:8

    Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Calpain; Caspases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Female; Glycoproteins; Immunohistochemistry; Leupeptins; Mice; Motor Neurons; Nerve Degeneration; Organ Culture Techniques; Spinal Cord; Spinal Cord Injuries; Time Factors

2006
Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4.
    Journal of cell science, 2006, Jul-01, Volume: 119, Issue:Pt 13

    Topics: Adenosine Triphosphatases; Animals; ATPases Associated with Diverse Cellular Activities; Carrier Proteins; Cells, Cultured; Chlorocebus aethiops; Cholesterol; COS Cells; Endosomal Sorting Complexes Required for Transport; Endosomes; Fibroblasts; Glycoproteins; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Glycoproteins; Mutant Proteins; Niemann-Pick C1 Protein; Protein Binding; Protein Processing, Post-Translational; Repressor Proteins; Skin; Ubiquitin; Vesicular Transport Proteins

2006
Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease.
    Chemistry & biology, 2006, Volume: 13, Issue:6

    Topics: Amino Acid Sequence; Crystallography, X-Ray; Cysteine Endopeptidases; Enzyme Activation; Escherichia coli; Gene Expression; Glutens; Hordeum; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Molecular Sequence Data; Pepsin A; Protein Folding; Protein Precursors; Protein Structure, Quaternary; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Trypsin

2006
Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase.
    Bioscience, biotechnology, and biochemistry, 2006, Volume: 70, Issue:9

    Topics: Amino Acid Sequence; Animals; Cathepsin L; Cathepsins; Chromatography, Gel; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; L-Lactate Dehydrogenase; Leucine; Leupeptins; Lysosomes; Male; Molecular Sequence Data; Rats; Rats, Wistar; Sequence Alignment

2006
Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Nov-08, Volume: 26, Issue:45

    Topics: Animals; Blotting, Western; Cells, Cultured; Cholesterol; Cricetinae; Cricetulus; Cysteine Proteinase Inhibitors; Gene Expression; Immunohistochemistry; Immunoprecipitation; Leupeptins; Membrane Microdomains; Mice; Mice, Neurologic Mutants; Mutant Proteins; Myelin Proteolipid Protein; Nerve Tissue Proteins; Oligodendroglia; Protein Transport; Subcellular Fractions; Time Factors; Transfection

2006
Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogen-induced cholestasis.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:3

    Topics: Animals; Aquaporins; Cell Membrane; Cell Membrane Permeability; Cholestasis; Cysteine Proteinase Inhibitors; Down-Regulation; Estradiol; Estrogens; Ethinyl Estradiol; Gene Expression; Hepatocytes; Leupeptins; Liver; Lysosomes; Male; Rats; Rats, Wistar; Water

2007
Synchronization of cell death in a dinoflagellate population is mediated by an excreted thiol protease.
    Environmental microbiology, 2007, Volume: 9, Issue:2

    Topics: Age Factors; Animals; Apoptosis; Biological Evolution; Biomass; Carbon Dioxide; Cysteine Endopeptidases; Dinoflagellida; DNA Fragmentation; Hydrogen Peroxide; Leupeptins; Oxidative Stress; Protozoan Proteins; Signal Transduction

2007
Isolation and characterization of a novel acid proteinase, tropiase, from Candida tropicalis IFO 0589.
    Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology, 2007, Volume: 48, Issue:1

    Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Bromosuccinimide; Candida tropicalis; Caseins; Chromatography; Electrophoresis; Fibrinogen; Guinea Pigs; Hydrolysis; Isoelectric Point; Leupeptins; Molecular Weight

2007
Peptide degradation is a critical determinant for cell-penetrating peptide uptake.
    Biochimica et biophysica acta, 2007, Volume: 1768, Issue:7

    Topics: Androstadienes; Animals; Carrier Proteins; Cell Membrane; Cell-Penetrating Peptides; Chloroquine; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Cytochalasin B; Deoxyglucose; Endocytosis; Leupeptins; Membrane Glycoproteins; Models, Biological; Nocodazole; Oligopeptides; Peptide Fragments; Peptides; Perforin; Phenanthrolines; Phenylmethylsulfonyl Fluoride; Pore Forming Cytotoxic Proteins; Protease Inhibitors; Protein Transport; Sodium Azide; Wortmannin

2007
Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations.
    Journal of neurochemistry, 2007, Volume: 101, Issue:6

    Topics: Acetylcysteine; Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; CHO Cells; Cricetinae; Cricetulus; Fibroblasts; Humans; Leupeptins; Mutation, Missense; Proteasome Inhibitors; Subcellular Fractions

2007
Babesia bovis: effects of cysteine protease inhibitors on in vitro growth.
    Experimental parasitology, 2007, Volume: 117, Issue:2

    Topics: Animals; Babesia bovis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Erythrocytes; Leucine; Leupeptins

2007
Endothelial gap junctions are down-regulated by arsenic trioxide.
    European journal of pharmacology, 2007, Aug-13, Volume: 569, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Line; Connexin 43; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Gap Junctions; Humans; Immunohistochemistry; Leupeptins; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxides; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; von Willebrand Factor

2007
Anthrax protective antigen cleavage and clearance from the blood of mice and rats.
    Infection and immunity, 2007, Volume: 75, Issue:11

    Topics: Animals; Anthrax; Antidotes; Antigens, Bacterial; Bacterial Toxins; Blood; Calcium; Coenzymes; Cysteine Proteinase Inhibitors; Enzyme-Linked Immunosorbent Assay; Leupeptins; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mutation; Peptide Hydrolases; Protein Binding; Rats; Rats, Inbred F344; Survival Analysis

2007
Cloning, site-directed mutagenesis and expression of cathepsin L-like cysteine protease from Uronema marinum (Ciliophora: Scuticociliatida).
    Molecular and biochemical parasitology, 2007, Volume: 156, Issue:2

    Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Protozoan; Enzyme Stability; Escherichia coli; Gene Expression; Gene Library; Hydrogen-Ion Concentration; Leucine; Leupeptins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligohymenophorea; Protein Folding; Protozoan Proteins; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid

2007
Structural basis of the zinc inhibition of human tissue kallikrein 5.
    Journal of molecular biology, 2007, Nov-02, Volume: 373, Issue:4

    Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Humans; Kallikreins; Kinetics; Leupeptins; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Substrate Specificity; Zinc

2007
Inhibition of high glucose-induced erythrocyte phosphatidylserine exposure by leupeptin and disaccharides.
    Cryobiology, 2008, Volume: 56, Issue:1

    Topics: Caspase 3; Caspase 8; Cell Size; Erythrocytes; Freeze Drying; Glucose; Hemolysis; Humans; Leupeptins; Lipid Peroxidation; Phosphatidylserines; Sucrose; Trehalose

2008
Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.
    Biochemical and biophysical research communications, 2008, Mar-14, Volume: 367, Issue:3

    Topics: Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Fluorescent Antibody Technique; Humans; Intracellular Fluid; Leupeptins; Lysosomes; Mice; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Time Factors

2008
Calpain inhibition protects spinal motoneurons from the excitotoxic effects of AMPA in vivo.
    Neurochemical research, 2008, Volume: 33, Issue:8

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Calpain; Cysteine Proteinase Inhibitors; Excitatory Amino Acid Agonists; Leupeptins; Male; Motor Neurons; Rats; Rats, Wistar; Rotarod Performance Test; Spinal Cord

2008
Target peptide sequence within infectious human immunodeficiency virus type 1 does not ensure envelope-specific T-helper cell reactivation: influences of cysteine protease and gamma interferon-induced thiol reductase activities.
    Clinical and vaccine immunology : CVI, 2008, Volume: 15, Issue:4

    Topics: Animals; Antigen Presentation; Cysteine Endopeptidases; env Gene Products, Human Immunodeficiency Virus; Erythrocyte Membrane; Histocompatibility Antigens Class II; HIV Infections; HIV-1; Humans; Hybridomas; Interferon-gamma; Interleukin-2; Leupeptins; Lymphocyte Activation; Mice; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; T-Lymphocytes, Helper-Inducer

2008
A novel 51-kDa fragment of the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase formed in the stroma of chloroplasts in dark-induced senescing wheat leaves.
    Physiologia plantarum, 2007, Volume: 131, Issue:1

    Topics: Chloroplasts; Darkness; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Leupeptins; Pepstatins; Phenanthrolines; Plant Leaves; Protein Subunits; Protons; Ribulose-Bisphosphate Carboxylase; Sulfones; Temperature; Triticum

2007
Endosomal proteases influence the repertoire of MAGE-A3 epitopes recognized in vivo by CD4+ T cells.
    Cancer research, 2008, Mar-01, Volume: 68, Issue:5

    Topics: Antigen Presentation; Antigens, Neoplasm; CD4-Positive T-Lymphocytes; Dendritic Cells; Endosomes; Epitopes; Humans; Immunophenotyping; Leukocytes, Mononuclear; Leupeptins; Models, Biological; Neoplasm Proteins; Pepstatins; Peptide Hydrolases; Peptides; Th2 Cells

2008
Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis.
    Biochemical and biophysical research communications, 2008, May-30, Volume: 370, Issue:2

    Topics: Benzamidines; Bronchi; Guanidines; Humans; Leupeptins; Myocytes, Smooth Muscle; Oligopeptides; Receptor, PAR-2; Transforming Growth Factor beta; Trypsin Inhibitors; Tryptases

2008
Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons.
    Neuroscience, 2008, May-02, Volume: 153, Issue:2

    Topics: Acetylcysteine; Animals; Blotting, Western; Cysteine Proteinase Inhibitors; Fibroblast Growth Factors; Ganglia, Spinal; Green Fluorescent Proteins; Leupeptins; Ligands; Lysosomes; Neurites; PC12 Cells; Pheochromocytoma; Rats; Receptor, Fibroblast Growth Factor, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Signal Transduction

2008
TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent.
    Traffic (Copenhagen, Denmark), 2008, Volume: 9, Issue:7

    Topics: Animals; Endosomes; Humans; Kinetics; Leupeptins; Lysosomes; Macrolides; Methylamines; Mutation; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Receptor, trkA; Subcellular Fractions; Ubiquitin

2008
Immune-complex assays for tyrosine protein kinases.
    Current protocols in immunology, 2001, Volume: Chapter 11

    Topics: Adenosine Triphosphate; Animals; Aprotinin; Autoradiography; Caseins; Cell Line, Tumor; Electrophoresis, Polyacrylamide Gel; Humans; Immunoprecipitation; Leupeptins; Peptides; Phenylmethylsulfonyl Fluoride; Phosphopyruvate Hydratase; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Sodium Fluoride; Structure-Activity Relationship; Time Factors; Vanadates

2001
Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Animals; Antimalarials; Biological Transport, Active; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Drug Resistance; Erythrocytes; Genes, Protozoan; Humans; In Vitro Techniques; Ion Channels; Leupeptins; Malaria, Falciparum; Plasmodium falciparum; Protozoan Proteins

2008
Role of the calcium-calpain pathway in cytoskeletal damage after eccentric contractions.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:1

    Topics: Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Cytoskeleton; Electric Stimulation; Extracellular Space; Immunohistochemistry; In Vitro Techniques; Leupeptins; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Signal Transduction

2008
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease.
    The American journal of pathology, 2008, Volume: 173, Issue:3

    Topics: Alzheimer Disease; Animals; Apoptosis; Autophagy; Blotting, Western; Brain; Caspase 3; Cysteine Proteinase Inhibitors; Disease Models, Animal; Enzyme Activation; Female; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraventricular; Leupeptins; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Neurons; Receptor Cross-Talk

2008
Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:4

    Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Cell Shape; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Leupeptins; Male; Microtubule-Associated Proteins; Myocytes, Cardiac; Necrosis; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Sirolimus; Time Factors; Vacuoles

2008
The periodontal pathogen Porphyromonas gingivalis sensitises human blood platelets to epinephrine.
    Platelets, 2008, Volume: 19, Issue:5

    Topics: Adhesins, Bacterial; Apyrase; Aspirin; Blood Platelets; Calcium Signaling; Cyclooxygenase Inhibitors; Cysteine Endopeptidases; Epinephrine; Gingipain Cysteine Endopeptidases; Humans; In Vitro Techniques; Leupeptins; Nephelometry and Turbidimetry; Oligopeptides; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Porphyromonas gingivalis; Protease Inhibitors; Pyrroles; Quinazolines; Receptors, Proteinase-Activated; Virulence; Yohimbine

2008
Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment.
    Experimental parasitology, 2008, Volume: 120, Issue:4

    Topics: Animals; Blotting, Western; Culture Media; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Hemiptera; Hydrogen-Ion Concentration; Leucine; Leupeptins; Microscopy, Fluorescence; Protozoan Proteins; Reducing Agents; Salivary Proteins and Peptides; Solanum lycopersicum; Trypanosomatina

2008
The 2,2',4,4',5,5'-hexachlorobiphenyl-enhanced degradation of connexin 43 involves both proteasomal and lysosomal activities.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 107, Issue:1

    Topics: Analysis of Variance; Animals; Cell Communication; Cell Line; Cell Membrane; Connexin 43; Extracellular Signal-Regulated MAP Kinases; Gap Junctions; Leupeptins; Liver; Lysosomes; Metabolic Networks and Pathways; Polychlorinated Biphenyls; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats

2009
Constitutive, agonist-accelerated, recycling and lysosomal degradation of GABA(B) receptors in cortical neurons.
    Molecular and cellular neurosciences, 2008, Volume: 39, Issue:4

    Topics: Animals; Baclofen; Biomarkers; Cell Line; Cells, Cultured; Cerebral Cortex; Clathrin; Cysteine Proteinase Inhibitors; Endocytosis; Endosomes; Female; GABA Agonists; GABA-B Receptor Agonists; Humans; Ionophores; Leupeptins; Lysosomes; Monensin; Neurons; Pregnancy; Rats; Rats, Wistar; Receptors, GABA-B

2008
Calpain-1 is required for hydrogen peroxide-induced myotube atrophy.
    American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:2

    Topics: Animals; Calpain; Caspase 3; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Hydrogen Peroxide; Leupeptins; Mice; Muscle Proteins; Muscular Atrophy; Myoblasts, Skeletal; Oxidative Stress; RNA Interference; Sarcomeres; Superoxide Dismutase; Time Factors; Transfection

2009
Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity.
    Journal of medicinal chemistry, 2009, Feb-12, Volume: 52, Issue:3

    Topics: Animals; Catalytic Domain; Crystallization; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Kinetics; Leupeptins; Models, Molecular; Plasmodium falciparum; Substrate Specificity

2009
G.B. Quan et al., Inhibition of high glucose-induced erythrocyte phosphatidylserine exposure by leupeptin and disaccharides, Cryobiology 56 (1) (2008) 53-61.
    Cryobiology, 2009, Volume: 58, Issue:2

    Topics: Cell Membrane Permeability; Disaccharides; Erythrocytes; Glucose; Humans; Leupeptins; Lipid Peroxidation; Malondialdehyde; Phosphatidylserines; Thiobarbiturates; Thiobarbituric Acid Reactive Substances

2009
Role of oxidative stress in ischemia-reperfusion-induced alterations in myofibrillar ATPase activities and gene expression in the heart.
    Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Calcium-Transporting ATPases; Cardiac Myosins; Catalase; Enzyme Inhibitors; Gene Expression Regulation; In Vitro Techniques; Leupeptins; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Myofibrils; Myosin Heavy Chains; Myosin Light Chains; Oxidative Stress; Perfusion; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Ventricular Dysfunction, Left; Ventricular Pressure; Xanthine; Xanthine Oxidase

2009
The comparison of parathyroid hormone degradation effect by various protease inhibitors in blood specimen.
    The Korean journal of laboratory medicine, 2009, Volume: 29, Issue:2

    Topics: Aprotinin; Blood Specimen Collection; Edetic Acid; Female; Humans; Leucine; Leupeptins; Male; Parathyroid Hormone; Protease Inhibitors; Time Factors

2009
2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells.
    Toxicology, 2009, Jun-16, Volume: 260, Issue:1-3

    Topics: Adherens Junctions; Animals; Axin Protein; beta Catenin; Blotting, Western; Cadherins; Cell Line; Cysteine Proteinase Inhibitors; Epithelial Cells; gamma Catenin; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Leupeptins; Liver; Lysosomes; Phosphorylation; Polychlorinated Biphenyls; Rats; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Transcription, Genetic

2009
HIV-1 integrase-hydrolyzing antibodies from sera of HIV-infected patients.
    Biochimie, 2009, Volume: 91, Issue:9

    Topics: Adolescent; Adult; Antibodies, Catalytic; Chromatography, Affinity; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; HIV Infections; HIV Integrase; Humans; Hydrolysis; Leupeptins; Male; Pepstatins; Protease Inhibitors; Sulfones; Young Adult

2009
Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Oct-13, Volume: 106, Issue:41

    Topics: Animals; Cerebral Cortex; Leupeptins; Lysosomes; Microscopy, Confocal; Neurons; Protein Subunits; Rats; Receptors, GABA-A; Synapses; Ubiquitin

2009
CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization.
    The Journal of biological chemistry, 2009, Dec-04, Volume: 284, Issue:49

    Topics: Autophagy; bcl-X Protein; Caspase 8; Caspases; CD11b Antigen; Cell Survival; Chemokine CCL2; Cytokines; Humans; Interleukin-6; Leucine; Leukocytes, Mononuclear; Leupeptins; Lipopolysaccharide Receptors; Macrophages; Monocytes; Proto-Oncogene Proteins c-bcl-2

2009
Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction.
    Nature cell biology, 2010, Volume: 12, Issue:3

    Topics: Endoplasmic Reticulum; Endoplasmic Reticulum, Smooth; Endosomal Sorting Complexes Required for Transport; Endosomes; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Leupeptins; Lysosomes; Microscopy, Electron; Multivesicular Bodies; Mutation; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; RNA, Small Interfering; Transfection

2010
Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste.
    Journal of the science of food and agriculture, 2010, Volume: 90, Issue:3

    Topics: Animals; Cathepsin L; Cysteine Proteases; Electrophoresis, Polyacrylamide Gel; Fish Products; Fish Proteins; Gels; Hot Temperature; Hydrolysis; Leucine; Leupeptins; Perciformes; Protease Inhibitors

2010
Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit.
    Antioxidants & redox signaling, 2010, Oct-01, Volume: 13, Issue:7

    Topics: Cell Line; Cytosol; Ferric Compounds; Ferritins; Humans; Iron; Leupeptins; Lysosomes; Mitochondria; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Quaternary Ammonium Compounds

2010
Human B-type natriuretic peptide is not degraded by meprin A.
    Biochemical pharmacology, 2010, Oct-01, Volume: 80, Issue:7

    Topics: Animals; Blood Pressure; Endopeptidases; Humans; Hydrolysis; Kidney; Leupeptins; Metalloendopeptidases; Natriuretic Peptide, Brain; Neprilysin; Peptide Hydrolases; Protease Inhibitors; Rats; Serine Proteases

2010
Collagenolytic activity in sonic extracts of Tannerella forsythia.
    Archives of oral biology, 2010, Volume: 55, Issue:8

    Topics: Bacteroides; Calcium Chloride; Cathepsins; Cell Line, Tumor; Chelating Agents; Collagen Type I; Cysteine; Cysteine Proteinase Inhibitors; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Ethylmaleimide; Gelatinases; Humans; Iodoacetamide; Iodoacetic Acid; Leucine; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone

2010
Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia.
    The Journal of surgical research, 2010, Volume: 164, Issue:1

    Topics: Animals; Cysteine Proteinase Inhibitors; Glutathione; Glutathione Disulfide; Heart Arrest, Induced; Leupeptins; Male; Microscopy, Electron, Transmission; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Time Factors

2010
Leupeptin-based inhibitors do not improve the mdx phenotype.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 299, Issue:5

    Topics: Animals; Biomarkers; Calcium-Binding Proteins; Calpain; Creatine Kinase; Cysteine Proteinase Inhibitors; Diaphragm; Disease Models, Animal; Dose-Response Relationship, Drug; Genotype; Leupeptins; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle Strength; Muscular Dystrophy, Duchenne; Necrosis; Phenotype; Proteasome Endopeptidase Complex; Time Factors

2010
Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.
    The FEBS journal, 2010, Volume: 277, Issue:21

    Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Biocatalysis; Blotting, Western; Calpain; Catalytic Domain; Cysteine Proteinase Inhibitors; Endosomal Sorting Complexes Required for Transport; Ethylmaleimide; Glutathione Transferase; Green Fluorescent Proteins; HEK293 Cells; Humans; Hydrolysis; Immunoprecipitation; Leucine; Leupeptins; Mutation; Oncogene Proteins; Protein Binding; Recombinant Fusion Proteins; Transfection

2010
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
    Oncogene, 2011, Feb-17, Volume: 30, Issue:7

    Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin

2011
A cysteine proteinase in the penetration glands of the cercariae of Cotylurus cornutus (Trematoda, Strigeidae).
    Parasitology research, 2011, Volume: 108, Issue:3

    Topics: Animals; Cathepsin B; Cercaria; Cysteine Proteases; Cysteine Proteinase Inhibitors; Dithioerythritol; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Ethylmaleimide; Histocytochemistry; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Leupeptins; Trematoda

2011
Induction of IL-13 production and upregulated expression of protease activated receptor-1 by RANTES in a mast cell line.
    Cytokine, 2011, Volume: 53, Issue:2

    Topics: Animals; Cell Line; Chemokine CCL5; Flow Cytometry; Humans; Interleukin-12; Interleukin-13; Leupeptins; Mast Cells; Mice; Oligopeptides; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thrombin; Trypsin; Tryptases; Up-Regulation

2011
Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.
    Biochemical and biophysical research communications, 2011, Jan-07, Volume: 404, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Cathepsins; Cell Line, Tumor; Cells, Cultured; Cysteine Proteinase Inhibitors; Desipramine; Enzyme Inhibitors; Fibroblasts; Fingolimod Hydrochloride; Humans; Hydrolases; Immunosuppressive Agents; Leupeptins; Mice; Neurons; Propylene Glycols; Sphingomyelin Phosphodiesterase; Sphingosine

2011
Intracochlear perfusion of leupeptin and z-VAD-FMK: influence of antiapoptotic agents on gunshot-induced hearing loss.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2011, Volume: 268, Issue:7

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Cysteine Proteinase Inhibitors; Firearms; Guinea Pigs; Hair Cells, Auditory; Hearing Loss, Noise-Induced; Infusions, Parenteral; Leupeptins; Time Factors

2011
Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion.
    Virology, 2011, May-10, Volume: 413, Issue:2

    Topics: Cell Fusion; Cell Line; Furin; Gene Expression Regulation, Viral; Humans; Leupeptins; Mutation; Peptide Hydrolases; Severe acute respiratory syndrome-related coronavirus; Trypsin; Virus Internalization

2011
Dendroaspis natriuretic peptide and the designer natriuretic peptide, CD-NP, are resistant to proteolytic inactivation.
    Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:1

    Topics: Atrial Natriuretic Factor; Cells, Cultured; Cysteine Proteinase Inhibitors; Elapid Venoms; Glycopeptides; HEK293 Cells; Humans; Hydrolysis; Intercellular Signaling Peptides and Proteins; Kidney; Leupeptins; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Neprilysin; Peptides; Receptors, Atrial Natriuretic Factor; Serine Proteinase Inhibitors

2011
Characterization of macroautophagic flux in vivo using a leupeptin-based assay.
    Autophagy, 2011, Volume: 7, Issue:6

    Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Dose-Response Relationship, Drug; Heterozygote; Homeostasis; Lactosylceramides; Leupeptins; Liver; Lysosomes; Male; Mice; Mice, Inbred C57BL; Spleen; Time Factors; Tissue Distribution

2011
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
    Autophagy, 2011, Volume: 7, Issue:9

    Topics: Amino Acid Sequence; Ammonia; Animals; Autophagy; Betaine-Homocysteine S-Methyltransferase; Cell Survival; Cysteine Endopeptidases; Hepatocytes; Humans; L-Lactate Dehydrogenase; Leupeptins; Lysosomes; Male; Mass Spectrometry; Models, Biological; Molecular Sequence Data; Peptide Fragments; Proteolysis; Rats; Rats, Wistar; Sequence Analysis, Protein; Time Factors

2011
Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells.
    Cell, 2011, May-27, Volume: 145, Issue:5

    Topics: Amino Acid Sequence; Crosses, Genetic; Erythrocytes; High-Throughput Screening Assays; Humans; Ion Channels; Leupeptins; Molecular Sequence Data; Mutation; Permeability; Plasmodium falciparum; Protozoan Proteins; Sequence Alignment

2011
Porphyromonas gingivalis promotes monocyte migration by activating MMP-9.
    Journal of periodontal research, 2012, Volume: 47, Issue:2

    Topics: Cathepsins; Cell Culture Techniques; Cell Line; Cell Movement; Chemotaxis, Leukocyte; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Precursors; Humans; Leupeptins; Lipopolysaccharide Receptors; Lipopolysaccharides; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Monocytes; Porphyromonas gingivalis; Protease Inhibitors; Tissue Inhibitor of Metalloproteinase-1

2012
Preliminary study on the effect of caspase-6 and calpain inhibitors on postmortem proteolysis of myofibrillar proteins in chicken breast muscle.
    Meat science, 2012, Volume: 90, Issue:3

    Topics: Animals; Caspase Inhibitors; Chickens; Desmin; Egtazic Acid; Glycoproteins; Leupeptins; Meat; Muscle Proteins; Myofibrils; Oligopeptides; Pectoralis Muscles; Postmortem Changes; Proteolysis; Troponin T

2012
Leupeptin enhances cell surface localization of fibroblast growth factor receptor 1 in adult sensory neurons by increased recycling.
    European journal of cell biology, 2012, Volume: 91, Issue:2

    Topics: Animals; Axons; Cell Membrane; Cell Movement; Endocytosis; Fibroblast Growth Factor 2; Ganglia, Spinal; Leupeptins; Lysosomes; Macrolides; Monensin; PC12 Cells; Protein Transport; Rats; Receptor, Fibroblast Growth Factor, Type 1; Sensory Receptor Cells; Signal Transduction

2012
Human salivary cystatin SA exhibits antimicrobial effect against Aggregatibacter actinomycetemcomitans.
    Journal of periodontal research, 2012, Volume: 47, Issue:5

    Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Bacterial Adhesion; Cathepsins; Chromatography, Affinity; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Epithelial Cells; Fusobacterium nucleatum; Humans; Immunoglobulin A, Secretory; Kallikreins; Lactoferrin; Leupeptins; Microscopy, Confocal; Mouth Mucosa; Porphyromonas gingivalis; Saliva; Salivary Cystatins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors

2012
Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Aug-15, Volume: 32, Issue:33

    Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Calcium; Calcium Ionophores; Calpain; Cycloheximide; Cysteine Proteinase Inhibitors; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Emetine; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Ionomycin; K Cl- Cotransporters; Leupeptins; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Protein Synthesis Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Statistics, Nonparametric; Symporters; Valine

2012
Sorting of the FGF receptor 1 in a human glioma cell line.
    Histochemistry and cell biology, 2013, Volume: 139, Issue:1

    Topics: Caveolins; Cell Line, Tumor; Cell Shape; Clathrin; Endocytosis; Endosomes; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Glioma; Humans; Leupeptins; Ligands; Luminescent Proteins; Lysosomal Membrane Proteins; Lysosomes; Phosphorylation; Protein Transport; Receptor, Fibroblast Growth Factor, Type 1; Time Factors; Transfection

2013
Matrix metalloprotease 2-mediated activation of Ca(2+)-ATPase by superoxide radical (O2*-) in plasma membrane of bovine pulmonary vascular smooth muscle.
    Indian journal of biochemistry & biophysics, 2002, Volume: 39, Issue:6

    Topics: Animals; Antipain; Calcium-Transporting ATPases; Cattle; Cell Membrane; Ethylmaleimide; Free Radicals; Hypoxanthine; Leupeptins; Lung; Matrix Metalloproteinase 2; Muscle, Smooth; Muscle, Smooth, Vascular; Oligopeptides; Oxygen; Pepstatins; Phenylmethylsulfonyl Fluoride; Superoxides; Tissue Inhibitor of Metalloproteinase-2; Trypsin Inhibitor, Bowman-Birk Soybean

2002
Altered T-cell responses by the periodontal pathogen Porphyromonas gingivalis.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Adhesins, Bacterial; Calcium; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Gingipain Cysteine Endopeptidases; Host-Pathogen Interactions; Humans; Interleukin-2; Jurkat Cells; Leupeptins; Luciferases; Microscopy, Confocal; NF-kappa B; Porphyromonas gingivalis; Proteolysis; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Transcription Factor AP-1

2012
The balance between receptor recycling and trafficking toward lysosomes determines synaptic strength during long-term depression.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Sep-19, Volume: 32, Issue:38

    Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Arabidopsis Proteins; Biophysics; Carrier Proteins; Cysteine Proteinase Inhibitors; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Green Fluorescent Proteins; GTP-Binding Proteins; Hippocampus; Leupeptins; Long-Term Potentiation; Long-Term Synaptic Depression; Lysosomes; Male; N-Methylaspartate; Neurons; Organ Culture Techniques; Protein Transport; Rats; Rats, Wistar; Receptors, AMPA; Statistics, Nonparametric; Synapses; Transfection

2012
Benzodiazepine treatment induces subtype-specific changes in GABA(A) receptor trafficking and decreases synaptic inhibition.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Nov-06, Volume: 109, Issue:45

    Topics: Animals; Benzodiazepines; Binding Sites; Cell Membrane; Endocytosis; Inhibitory Postsynaptic Potentials; Leupeptins; Neural Inhibition; Neurons; Protein Subunits; Protein Transport; Rats; Receptors, GABA-A; Synapses

2012
Dephosphorylation reduces passage of ovalbumin antigen through intestinal epithelial Caco-2 cell monolayers.
    Journal of biochemistry, 2013, Volume: 153, Issue:4

    Topics: Alkaline Phosphatase; Animals; Antigens; Caco-2 Cells; Cathepsins; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Female; Humans; Intestinal Mucosa; Leupeptins; Mice; Mice, Inbred Strains; Ovalbumin; Pepstatins; Phosphorylation; Protease Inhibitors

2013
Profiling drug-induced cell death pathways in the zebrafish lateral line.
    Apoptosis : an international journal on programmed cell death, 2013, Volume: 18, Issue:4

    Topics: Animals; Antioxidants; Benzamidines; Calpain; Caspase Inhibitors; Cell Death; Cells, Cultured; Cisplatin; Cross-Linking Reagents; Gentamicins; Guanidines; Hair Cells, Auditory, Inner; Lateral Line System; Leupeptins; Methionine; Neomycin; Oligopeptides; Protease Inhibitors; Protein Synthesis Inhibitors; Reactive Oxygen Species; Zebrafish

2013
Inhibition of proteolysis in histiotrophic nutrition pathways alters DNA methylation and one-carbon metabolism in the organogenesis-stage rat conceptus.
    The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:8

    Topics: Animals; Base Sequence; Carbon; DNA Methylation; Embryo Culture Techniques; Epigenesis, Genetic; Female; Leupeptins; Methionine Adenosyltransferase; Micronutrients; Molecular Sequence Data; Nutritional Physiological Phenomena; Organogenesis; Promoter Regions, Genetic; Proteolysis; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine

2013
Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Androgens; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Dihydrotestosterone; Humans; Leucine; Leupeptins; Lysosomes; Male; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, Androgen; Transcriptome; Up-Regulation

2013
LL-37 in periodontal health and disease and its susceptibility to degradation by proteinases present in gingival crevicular fluid.
    Journal of clinical periodontology, 2013, Volume: 40, Issue:10

    Topics: Adhesins, Bacterial; Adult; Aged; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Cathelicidins; Cysteine Endopeptidases; Cysteine Proteases; Cysteine Proteinase Inhibitors; Dental Plaque; Enzyme-Linked Immunosorbent Assay; Gingipain Cysteine Endopeptidases; Gingival Crevicular Fluid; Humans; Leupeptins; Middle Aged; Peptide Fragments; Periodontitis; Periodontium; Porphyromonas gingivalis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tosyllysine Chloromethyl Ketone

2013
Inhibitory effects of sword bean extract on alveolar bone resorption induced in rats by Porphyromonas gingivalis infection.
    Journal of periodontal research, 2014, Volume: 49, Issue:6

    Topics: Adhesins, Bacterial; Alveolar Bone Loss; Animals; Bacteroidaceae Infections; Canavalia; Canavanine; Chlorhexidine; Chromatography, High Pressure Liquid; Cystatins; Cysteine Endopeptidases; Disease Progression; Epithelial Cells; Gingipain Cysteine Endopeptidases; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; KB Cells; Leupeptins; Male; Microbial Sensitivity Tests; Mouth Mucosa; Phytotherapy; Plant Extracts; Porphyromonas gingivalis; Rats; Rats, Wistar; Specific Pathogen-Free Organisms

2014
Inhibition of calpains fails to improve regeneration through a peripheral nerve conduit.
    Neuroscience letters, 2014, Apr-30, Volume: 566

    Topics: Action Potentials; Animals; Calpain; Cysteine Proteinase Inhibitors; Leupeptins; Male; Muscle, Skeletal; Nerve Regeneration; Neural Conduction; Rats, Sprague-Dawley; Sciatic Nerve

2014
Enhanced rate of degradation of basic proteins by 26S immunoproteasomes.
    Biochimica et biophysica acta, 2014, Volume: 1843, Issue:9

    Topics: Animals; Histones; Hydrolysis; Kinetics; Leupeptins; Molecular Weight; Peptides; Proteasome Endopeptidase Complex; Proteolysis; Rabbits; Trypsin

2014
Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons.
    Scientific reports, 2014, Jul-17, Volume: 4

    Topics: Animals; Cells, Cultured; Cerebral Cortex; Culture Media; Leupeptins; Lysosomes; Mice, Inbred C57BL; Neurons; Phosphorylation; Primary Cell Culture; Protein Processing, Post-Translational; tau Proteins

2014
Nostosins, Trypsin Inhibitors Isolated from the Terrestrial Cyanobacterium Nostoc sp. Strain FSN.
    Journal of natural products, 2014, Aug-22, Volume: 77, Issue:8

    Topics: Inhibitory Concentration 50; Iran; Leupeptins; Molecular Structure; Nostoc; Oligopeptides; Trypsin Inhibitors

2014
Effects of copper overload in P19 neurons: impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis.
    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2014, Volume: 27, Issue:6

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Apoptosis Regulatory Proteins; Calpain; Caspases; Cell Line, Tumor; Chelating Agents; Chromatin; Copper Sulfate; Dizocilpine Maleate; Gene Expression Regulation; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Leupeptins; Mice; Neoplasm Proteins; Neurons; Nifedipine; Oxidation-Reduction; Oxidative Stress; Protease Inhibitors; Protein Kinase Inhibitors; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Teratocarcinoma

2014
Ferritin-stimulated lipid peroxidation, lysosomal leak, and macroautophagy promote lysosomal "metastability" in primary hepatocytes determining in vitro cell survival.
    Free radical biology & medicine, 2015, Volume: 80

    Topics: Adenine; Aldehydes; Animals; Apoptosis; Autophagy; Culture Media, Conditioned; Endocytosis; Epidermal Growth Factor; Female; Ferritins; Glutathione; Glutathione Disulfide; Hepatocytes; Intracellular Membranes; Iron Chelating Agents; Leupeptins; Liver; Lysosomes; Molecular Imaging; Permeability; Primary Cell Culture; Protease Inhibitors; Protein Aggregates; Rats; Rats, Inbred F344

2015
Autophagic flux determination in vivo and ex vivo.
    Methods (San Diego, Calif.), 2015, Volume: 75

    Topics: Animals; Autophagy; Cerebellum; Leupeptins; Liver; Lysosomes; Mice; Microscopy, Fluorescence; Retina

2015
Comparative response of rat and rabbit conceptuses in vitro to inhibitors of histiotrophic nutrition.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2015, Volume: 104, Issue:1

    Topics: Animal Nutritional Physiological Phenomena; Animals; Antibodies; Embryo, Mammalian; Embryonic Development; Female; Fetus; Leupeptins; Rabbits; Rats, Sprague-Dawley; Receptors, Cell Surface; Staining and Labeling; Trypan Blue

2015
Affinity screening using competitive binding with fluorine-19 hyperpolarized ligands.
    Angewandte Chemie (International ed. in English), 2015, Apr-13, Volume: 54, Issue:16

    Topics: Benzamidines; Benzylamines; Binding, Competitive; Fluorine; Kinetics; Leupeptins; Ligands; Magnetic Resonance Spectroscopy; Monte Carlo Method; Trypsin

2015
A CLAG3 mutation in an amphipathic transmembrane domain alters malaria parasite nutrient channels and confers leupeptin resistance.
    Infection and immunity, 2015, Volume: 83, Issue:6

    Topics: Amino Acid Sequence; Animals; Biological Transport; Cell Membrane; Computer Simulation; Cysteine Proteinase Inhibitors; Drug Resistance; Gene Expression Regulation; Genome, Protozoan; Leupeptins; Models, Biological; Molecular Sequence Data; Mutation; Plasmodium falciparum; Protein Structure, Tertiary; Protozoan Proteins

2015
Amino acid starvation induced by protease inhibition produces differential alterations in redox status and the thiol proteome in organogenesis-stage rat embryos and visceral yolk sacs.
    The Journal of nutritional biochemistry, 2015, Volume: 26, Issue:12

    Topics: Amino Acids; Animals; Culture Media; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Glutathione; Leupeptins; Lysosomes; Organogenesis; Oxidation-Reduction; Protease Inhibitors; Proteolysis; Proteome; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sulfhydryl Compounds; Yolk Sac

2015
Measurement of allergen-specific secretory IgA in stool of neonates, infants and toddlers by protection against degradation of immunoglobulins and allergens.
    The journal of medical investigation : JMI, 2015, Volume: 62, Issue:3-4

    Topics: Allergens; Child, Preschool; Feces; Humans; Immunoglobulin A, Secretory; Infant; Infant, Newborn; Leupeptins; Phenylmethylsulfonyl Fluoride; Protein Array Analysis; Serine Proteinase Inhibitors

2015
Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus.
    Journal of neuroimmunology, 2015, Oct-15, Volume: 287

    Topics: Adolescent; Animals; Autistic Disorder; Brain; Child; Child, Preschool; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Female; Hippocampus; Humans; Immunoglobulin A; In Vitro Techniques; Leupeptins; Long-Term Potentiation; Male; Myelin Basic Protein; Patch-Clamp Techniques; Proteolysis; Rats; Rats, Sprague-Dawley; Synaptic Transmission

2015
Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization.
    Brain research bulletin, 2016, Volume: 120

    Topics: Botulinum Toxins, Type A; Cell Membrane; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Dynamins; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hydrazones; Immunohistochemistry; Isoxazoles; Leupeptins; Membrane Potentials; Patch-Clamp Techniques; Receptors, GABA-A; Recombinant Proteins; Transfection

2016
The fine tuning of metabolism, autophagy and differentiation during in vitro myogenesis.
    Cell death & disease, 2016, Mar-31, Volume: 7

    Topics: Ammonium Chloride; Animals; Autophagy; Beclin-1; Cell Differentiation; Cells, Cultured; Leupeptins; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Microscopy, Confocal; Microtubule-Associated Proteins; Mitochondria; Multiprotein Complexes; Muscle Fibers, Skeletal; Myoblasts; RNA Interference; RNA, Small Interfering; Satellite Cells, Skeletal Muscle; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53

2016
Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition.
    Bioscience reports, 2014, 02-01, Volume: 34, Issue:1

    Topics: Biological Transport, Active; Cell Line, Tumor; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lysosomal-Associated Membrane Protein 2; Lysosomes; Neurons; Vitamin B 12

2014
Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die.
    Cell death and differentiation, 2017, Volume: 24, Issue:2

    Topics: Acetylcysteine; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Cells, Cultured; Hippocampus; Ischemia; Leupeptins; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Phosphorylation; Rats; RNA Interference; Sirolimus; TOR Serine-Threonine Kinases

2017
Gelatin Zymography Using Leupeptin for the Detection of Various Cathepsin L Forms.
    Methods in molecular biology (Clifton, N.J.), 2017, Volume: 1594

    Topics: Cathepsin L; Cells, Cultured; Enzyme Assays; Gelatin; Humans; Leupeptins; Lysosomes; Phosphorylation

2017
Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis.
    Scientific reports, 2017, 08-22, Volume: 7, Issue:1

    Topics: Animals; Autophagy; Cell Line; Diet, High-Fat; Disease Models, Animal; Humans; Insulin; Leupeptins; Lipolysis; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Palmitic Acid; Pioglitazone; PPAR alpha; PPAR gamma; Triglycerides

2017
Kinetic studies of serine protease inhibitors in simple and rapid 'active barrier' model systems - Diffusion through an inhibitor barrier.
    Analytical biochemistry, 2018, 04-01, Volume: 546

    Topics: Antipain; Diffusion; Dose-Response Relationship, Drug; Gelatin; Kinetics; Leupeptins; Models, Biological; Oligopeptides; Particle Size; Peptide Hydrolases; Serine Proteinase Inhibitors; Spectrophotometry; Structure-Activity Relationship; Surface Properties

2018
Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.
    Scientific reports, 2018, Jul-16, Volume: 8, Issue:1

    Topics: Allosteric Regulation; Allosteric Site; Calcium; Cations, Divalent; Crystallography, X-Ray; Kallikreins; Kinetics; Leupeptins; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Structure, Tertiary; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Zinc

2018
Controlled cortical impact-induced neurodegeneration decreases after administration of the novel calpain-inhibitor Gabadur.
    Brain research bulletin, 2018, Volume: 142

    Topics: Animals; Brain; Brain Injuries, Traumatic; Calpain; Disease Models, Animal; Glycoproteins; Leupeptins; Molecular Structure; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Pregabalin; Rats, Sprague-Dawley

2018
Insertion sequence 1 from calpain-3 is functional in calpain-2 as an internal propeptide.
    The Journal of biological chemistry, 2018, 11-16, Volume: 293, Issue:46

    Topics: Calcium; Calcium-Binding Proteins; Calpain; Cysteine Proteinase Inhibitors; DNA Transposable Elements; Isoenzymes; Leucine; Leupeptins; Muscle Proteins; Protein Conformation; Proteolysis; Recombinant Proteins

2018
Autophagosome immunoisolation from GFP-LC3B mouse tissue.
    Autophagy, 2019, Volume: 15, Issue:2

    Topics: Animals; Autophagosomes; Biomarkers; Green Fluorescent Proteins; Leupeptins; Mice, Transgenic; Microtubule-Associated Proteins; Organ Specificity

2019
Characterization of PdCP1, a serine carboxypeptidase from Pseudogymnoascus destructans, the causal agent of White-nose Syndrome.
    Biological chemistry, 2018, 11-27, Volume: 399, Issue:12

    Topics: Animals; Antipain; Ascomycota; Carboxypeptidases; Chiroptera; Leupeptins; Mycoses; Syndrome

2018
Measurement of Bulk Autophagy by a Cargo Sequestration Assay.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1880

    Topics: Animals; Autophagosomes; Autophagy; Cell Culture Techniques; Cytosol; Electroporation; Enzyme Assays; Humans; L-Lactate Dehydrogenase; Leupeptins; Lysosomes; Macrolides

2019
Measuring Nonselective and Selective Autophagy in the Liver.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1880

    Topics: Animals; Autophagosomes; Autophagy; Centrifugation, Density Gradient; Cysteine Proteases; Cysteine Proteinase Inhibitors; Leupeptins; Liver; Lysosomes; Male; Mice; Mice, Inbred C57BL; Models, Animal; Rats; Rats, Wistar

2019
Analysis of Chaperone-Mediated Autophagy.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1880

    Topics: Ammonium Chloride; Animals; Autophagy; Biological Assay; Female; Leupeptins; Liver; Lysosomes; Male; Mice; Mice, Inbred C57BL; Molecular Chaperones; Proteolysis; Rats; Rats, Wistar

2019
    American journal of respiratory cell and molecular biology, 2019, Volume: 61, Issue:6

    Topics: Aprotinin; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Leupeptins; Protein Folding; Protein Processing, Post-Translational; Protein Stability; Proteolysis; RNA Interference; RNA, Small Interfering; S-Nitrosoglutathione; S-Nitrosothiols; Ubiquitin-Protein Ligases; Ubiquitination

2019
Effects of Five Substances with Different Modes of Action on Cathepsin H, C and L Activities in Zebrafish Embryos.
    International journal of environmental research and public health, 2019, 10-17, Volume: 16, Issue:20

    Topics: Animals; Cathepsin C; Cathepsin H; Cathepsin L; Cysteine Proteinase Inhibitors; Embryo, Nonmammalian; Leupeptins; Zebrafish

2019
Thrombin alters the synthesis and processing of CYR61/CCN1 in human corneal stromal fibroblasts and myofibroblasts through multiple distinct mechanisms.
    Molecular vision, 2020, Volume: 26

    Topics: Alternative Splicing; Cell Differentiation; Corneal Stroma; Culture Media, Conditioned; Cysteine-Rich Protein 61; Fibroblast Growth Factor 2; Fibroblasts; Hirudins; Humans; Leupeptins; Myofibroblasts; Primary Cell Culture; Proteolysis; Pyrroles; Quinazolines; Receptors, Proteinase-Activated; RNA, Messenger; Signal Transduction; Stromal Cells; Thrombin; Transforming Growth Factor beta1

2020
In vitro effect of a novel protease inhibitor cocktail on Toxoplasma gondii tachyzoites.
    Experimental parasitology, 2020, Volume: 219

    Topics: Analysis of Variance; Animals; Aprotinin; Culture Media, Serum-Free; Cysteine Proteinase Inhibitors; Drug Combinations; Hep G2 Cells; Humans; Leucine; Leupeptins; Mice; Microscopy, Electron, Transmission; Organelles; Pilot Projects; Protease Inhibitors; Serine Proteinase Inhibitors; Statistics, Nonparametric; Sulfones; Toxoplasma

2020
Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice.
    Archives of toxicology, 2021, Volume: 95, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Autophagy; Cell Death; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Leupeptins; Male; Mice; Mice, Inbred C57BL; Mitochondria; Proteins

2021
Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations.
    Applied biochemistry and biotechnology, 2021, Volume: 193, Issue:6

    Topics: Antiviral Agents; Benzamidines; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Esters; Guanidines; Humans; Leupeptins; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; SARS-CoV-2; Serine Endopeptidases

2021
Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs.
    mBio, 2021, 10-26, Volume: 12, Issue:5

    Topics: Animals; Chlorocebus aethiops; COVID-19 Drug Treatment; Ecosystem; Humans; Leupeptins; Medicine, Chinese Traditional; SARS-CoV-2; Vero Cells

2021