leupeptin has been researched along with leupeptins in 893 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 325 (36.39) | 18.7374 |
| 1990's | 332 (37.18) | 18.2507 |
| 2000's | 166 (18.59) | 29.6817 |
| 2010's | 65 (7.28) | 24.3611 |
| 2020's | 5 (0.56) | 2.80 |
| Authors | Studies |
|---|---|
| Martonosi, A; Varga, S | 1 |
| Isobe, N; Kaneko, H; Nakatsuka, I; Saito, K; Yamada, H; Yoshitake, A | 1 |
| Ashall, F; Djamgoz, MB; Floyd, DN | 1 |
| Ramanujam, KS; Seetharam, B; Seetharam, S | 2 |
| Eto, I; Grubbs, CJ | 1 |
| Denison, MR; Giangreco, B; Hughes, SA; Leibowitz, JL; Olson, AL; Perlman, S; Weiss, SR; Zoltick, PW | 1 |
| Clementi, F; Passafaro, M; Sher, E | 1 |
| Diment, S; Rodriguez, GM | 1 |
| Morton, PA; Owensby, DA; Schwartz, AL; Underhill, DM | 1 |
| Ivy, GO | 2 |
| Kilbourne, EJ; Lewis, EJ; McMahon, A; Nankova, BB; Osaka, H; Sabban, DB; Sabban, EL | 1 |
| Hara, M; Inagaki, C; Omori, K; Otani, H; Zeng, XT | 1 |
| Carlton, E; Morgan, CH; Pandian, MR; Segre, GV | 1 |
| Bang, YJ; Danielpour, D; Kim, KY; Kim, SJ; Myers, CE; O'Reilly, MA; Trepel, JB | 1 |
| Cappuccinelli, P; Fíori, PL; Manca, C; Mattana, A; Rappelli, P | 1 |
| Berndt, MC; Ribeiro, A; Swann, JC | 1 |
| Berg, T; Roseng, L; Tolleshaug, H | 1 |
| Bevan, D; Harrison, P; Inbal, A; Lawrie, A; LeRoy, F; Rowley, M; Savidge, G; Wilbourn, B | 1 |
| Chevalier, D; Moore, RB; Plishker, GA; Seinsoth, L | 1 |
| Badalamente, MA; Hurst, LC; Stracher, A | 3 |
| Marinelli, RA; Peñalva, GL | 1 |
| Banerjee, D; Grieninger, G; Mukhopadhyay, G; Oddoux, C; Overton, O; Redman, C; Roy, S; Yu, S | 1 |
| Lopata, A; Tawia, SA | 1 |
| Fukushima, T; Sasaki, H; Sekizawa, K; Takishima, T; Yamauchi, K; Yamaya, M; Zayasu, K | 1 |
| Azuma, M; David, LL; Kadoya, K; Lampi, KJ; Shearer, TR | 1 |
| Bailey, GS; el-Thaher, TS; Moore, GR; Osborne, M; Wilson, MT | 1 |
| Niwano, H; Shibata, A; Takahashi, H; Tatewaki, W; Wada, K | 1 |
| Kumar, A; Shafiq, S; Stracher, A; Wadgaonkar, R | 1 |
| Dobberstein, B; Griffiths, G; Zachgo, S | 1 |
| Mizuno, K; Nakamura, T; Takehara, T | 1 |
| DeMartino, GN; Dick, LR; Moomaw, CR; Pramanik, BC; Slaughter, CA | 1 |
| Heikoop, JC; Just, WW; Meijer, AJ; Strijland, A; Tager, JM; van den Berg, M; Weijers, PJ | 1 |
| Tai, H; Yamaguchi, M | 1 |
| Benacerraf, B; Colarusso, LJ; Falo, LD; Rock, KL | 1 |
| Bianchi, CP; Booz, GW | 1 |
| Aoba, A; Asakura, M; Hasegawa, K; Ivy, GO; Kanai, S; Kitani, K; Ohta, M; Shibata, M | 1 |
| Bisiau, H; Degand, P; Demeyer, D; Han, KK; Huet, G; Richet, C; Soudan, B; Tetaert, D | 1 |
| Legaard, PK; LeGrand, RD; Misfeldt, ML | 1 |
| Aoyagi, T; Hayashi, H; Hori, M; Moriya, Y; Nagai, M; Otani, T; Sakata, N; Tsuchiya, KS | 1 |
| Kenney, DM; Remold-O'Donnell, E; Van Brocklyn, J | 1 |
| Bacher, A; Ben-Shaul, Y; Griebl, K; Mackamul, S; Mitreiter, R; Mückter, H | 1 |
| Haspel, HC; Honkanen, RA; Klingman, DE; Ortiz, PA | 1 |
| Haass, C; Hung, AY; Koo, EH; Mellon, A; Selkoe, DJ | 1 |
| Choudhuri, S; Klaassen, CD; McKim, JM | 1 |
| Chowdhury, MH; Dempster, DW; Hamada, C | 1 |
| Knops, J; Lieberburg, I; Sinha, S | 1 |
| Boschwitz, H; Gofshtein-Gandman, L; Halvorson, HO; Keynan, A; Milner, Y | 1 |
| Danielsen, EM; Hansen, GH; Wetterberg, LL | 1 |
| Aoyagi, T; Harada, S; Hirokawa, K; Kojima, F; Nagai, M; Takahashi, H; Takeuchi, T; Tsumita, T; Wada, T | 1 |
| Homma, S; Oppenheim, RW; Prevette, D; Tytell, M | 1 |
| Diment, S | 1 |
| Grun, JL; Liu, DC; Maurer, PH | 1 |
| Anonick, PK; Gonias, SL | 1 |
| Jani, JP; Lazo, JS; Mistry, JS; Morris, G; Sebti, SM | 1 |
| Clarke, GA; Garrett, JR; Proctor, GB; Smith, RE | 1 |
| Katunuma, N; Kominami, E; Muno, D; Ueno, T | 1 |
| Smith, RS; Snyder, RE | 1 |
| Chiyotani, A; Isono, K; Kanemura, T; Konno, K; Sakai, N; Takizawa, T; Tamaoki, J; Yamauchi, F | 1 |
| Bettens, F; Brander, C; Mijic, D; Pichler, WJ; Wyss-Coray, T | 1 |
| Bittar, EE; Huang, YP | 1 |
| Ichinose, M; Inoue, H; Katsumata, U; Kimura, K; Miura, M; Takahashi, T; Takishima, T | 1 |
| Estus, S; Golde, TE; Selkoe, DJ; Younkin, LH; Younkin, SG | 1 |
| Horiuchi, S; Inokuchi, T; Kobayashi, KI | 1 |
| Bhattacharyya, J; Sayeed, MM; Thompson, K | 1 |
| Rivett, AJ; Savory, PJ | 2 |
| Baron, PL; Meola, G; Moggio, M; Santilli, I; Scarlato, G; Scarpini, E | 1 |
| Collins, AR; Grubb, A | 1 |
| Chiyotani, A; Horii, S; Isono, K; Kanemura, T; Kobayashi, K; Sakai, N; Takeuchi, S; Takizawa, T; Tamaoki, J; Yamawaki, I | 1 |
| Anderson, SK; Geissler, F; Press, O | 1 |
| Aubery, M; Bauvy, C; Codogno, P; Darmoul, D; Ogier-Denis, E; Sapin, C; Trugnan, G | 1 |
| Arai, A; Frank, S; Lee, KS; Lynch, G; Vanderklish, P | 1 |
| Knutson, VP | 1 |
| Benacerraf, B; Rock, KL; Vidard, L | 1 |
| Hanawalt, PC; Hebda, PA; Kane, CJ; Mansbridge, JN | 1 |
| Ortiz, C; Scott, AI; Stolowich, NJ; Tellier, C; Williams, H | 1 |
| Hayashi, M; Inomata, M; Ito, H; Kawashima, S; Saito, Y | 1 |
| Fridman, R; Hamilton, TC; Kanemoto, T; Martin, GR | 1 |
| Adams, GE; Cundall, RB; Hasan, NM | 1 |
| Ginsburg, H; Krugliak, M | 1 |
| Gardner, MB; Gershwin, ME; McGraw, TP; Vowels, BR | 1 |
| Beermann, ML; Nixon, RA; Shea, TB | 1 |
| Axelsson, KL; Hellem, S; Olofsson, J; Rydell, EL | 1 |
| Dimlich, RV; Fischer, JE; Hall-Angerås, M; Hasselgren, PO | 1 |
| DeMartino, GN; Dick, LR; Moomaw, CR; Slaughter, CA | 1 |
| Edwards, RH; MacLennan, PA; McArdle, A | 1 |
| Olaya, P; Wasserman, M | 1 |
| Charest, DL; Howard, SL; Pelech, SL; Salari, H; Samiei, M | 1 |
| Ivy, GO; Kanai, S; Kitani, K; Ohta, M; Otsubo, K; Sato, Y | 1 |
| Schlaepfer, WW; Zimmerman, UJ | 2 |
| Khalfan, HA | 1 |
| Mercer, JR; Silva, SV | 1 |
| Armstrong, DL; Denny, JB; Ghuman, A; Polan-Curtain, J; Wayner, MJ | 1 |
| Horton, AA; Wood, JM | 1 |
| Augustine, EC; Kensinger, RS | 1 |
| Mauss, EA; Puszkin, EG; Zucker, MB | 1 |
| Blum, JS; Cresswell, P; Davis, JE; Marks, MS | 1 |
| Goldberg, IJ; Klein, MG; Saxena, U | 1 |
| Feher, JJ; LeBolt, WR | 1 |
| Arai, A; Kessler, M; Lee, K; Lynch, G | 1 |
| Grisolía, S; Knecht, E; Vargas, JL | 1 |
| Angerås, U; Benson, D; Fischer, JE; Hall-Angerås, M; Hasselgren, PO; James, JH | 1 |
| Hoshi, M; Sawada, H; Yamazaki, K | 1 |
| Grisolía, S; Hernández-Yago, J; Knecht, E; Vargas, JL | 1 |
| Hirose, M; Kominami, E; Namihisa, T; Ueno, T; Watanabe, S | 1 |
| Danno, K; Hirayoshi, K; Hosokawa, M; Imamura, S; Miyachi, Y; Nagata, K; Nishigori, C; Takeda, T; Tanaka, T; Utani, A | 1 |
| Clem, LW; Jørgensen, T; Miller, NW; Vallejo, AN | 1 |
| Sano, M; Seto, A; Tsukimura, T; Yamazaki, A | 1 |
| Gottesman, MM; Salminen, A | 1 |
| Adachi, Y; Hatanaka, M; Lee, WJ; Maki, M; Murachi, T | 1 |
| Liuzzi, FJ | 1 |
| Billington, D; Gilmore, IT; Gore, S; Morris, AI | 1 |
| Bohley, P; Gordon, PB; Kisen, GO; Kopitz, J; Seglen, PO | 1 |
| Nafz, MA; Varandani, PT | 1 |
| Daikuhara, Y; Gohda, E; Hashimoto, S; Miyazaki, H; Nakayama, H; Nakazono, Y; Tsubouchi, H | 1 |
| Friedman, V; Lonai, P; Puri, J | 1 |
| Chida, K; Kato, N; Kuroki, T | 1 |
| Atwood, HL; Boegman, RJ; Scarth, B | 1 |
| Ino, Y; Iwaki, M; Sato, T; Suzuki, K | 1 |
| Chad, JE; Eckert, R; Kalman, D | 1 |
| Conner, RL; Deyo, RA; Panksepp, J | 1 |
| Birnbaumer, L; Brown, AM; Codina, J; Imoto, Y; Reeves, JP; Yatani, A | 1 |
| Nishimura, C; Nishimura, T; Suzuki, H; Tanaka, N | 1 |
| Garg, BD; Mancini, MA; Olson, MJ; Roy, AK | 1 |
| Chen, JK; Cook, JR | 1 |
| Findlay, I | 1 |
| Alkon, DL; Bank, B; Chen, C; Gallant, P; Kubota, M; Naito, S; Rasmussen, H; Smallwood, J | 1 |
| Castiglione, E; Chatterjee, S; Ghosh, N; Kwiterovich, PO | 1 |
| Eisenlohr, LC; Gerhard, W; Hackett, CJ | 1 |
| Dufy, B; Taupignon, AI | 1 |
| Lasek, RJ; Sahenk, Z | 1 |
| Berzofsky, JA; Cease, KB; Takahashi, H | 1 |
| Bazan, JF; Cary, SM; Dougherty, WG; Fletterick, RJ; Parks, TD | 1 |
| Bowles, VM; Carnegie, PR; Sandeman, RM | 1 |
| Kihara, HK; Miyata, S; Yoshida, Y | 1 |
| Berra, A; Monserrat, AJ; Porta, EA; Rubio, MC | 1 |
| Ivy, GO; Kanai, S; Kitani, K; Kobayashi, M; Ohta, M; Sato, Y; Smith, G | 1 |
| Ivy, GO; Kanai, S; Kitani, K; Nokubo, M; Ohta, M; Otsubo, K; Sato, Y | 1 |
| Banker, DE; Gottesman, MM; Herschman, HR; Pastan, I | 1 |
| Boscá, L; Díaz-Guerra, MJ; Mojena, M | 1 |
| Bouillot, C; Disdier, M; Dubernard, V; Legrand, C; Nurden, AT; Pidard, D | 1 |
| Lozano, JA; Martinez, JH; Solano, F | 1 |
| Buettner, HM; Ivins, JK; Pittman, RN | 1 |
| Amara, JF; Lederkremer, G; Lodish, HF | 1 |
| Bennett, V; Davis, J; Davis, L | 1 |
| Au, KS; Lee, MF; Siu, YL | 1 |
| Ishida, E; Ito, M; Sato, A; Shigeta, S; Takami, Y; Tanabe, F | 1 |
| Bradford, H; Colman, RF; Colman, RW; Hu, CJ; Puri, RN; Zhou, FX | 1 |
| Hirata, Y; Inoue, Y; Marumo, K; Tasaka, Y | 1 |
| Nishikata, M; Nodasaka, Y; Yoshimura, F | 1 |
| Dosch, SF; Graziani, LA; Pickart, CM | 1 |
| Rizzolo, LJ | 1 |
| Gerrard, JM; MacIntyre, DE; McNicol, A | 1 |
| Beertsen, W; Everts, V; Hembry, RM; Reynolds, JJ | 1 |
| Hayashi, M; Inomata, M; Kawashima, S; Nakamura, M; Saito, Y | 1 |
| Clarke, BL; Weigel, PH | 1 |
| Alpers, DH; Ramasamy, M; Seetharam, B; Tiruppathi, C | 1 |
| Fesus, L; Tarcsa, E | 1 |
| Berlet, HH; Ilzenhöfer, H | 1 |
| Donlon, JA; Donlon, MA; Helgeson, EA | 1 |
| Bajusz, S; Makara, GB; Nagy, I; Rappay, G | 1 |
| Dieffenbach, CW; Friedman, RM; Jacobsen, H; Krause, D; Leisy, SA; Silverman, RH | 1 |
| Dallinga-Thie, GM; van 't Hooft, FM; van Tol, A | 1 |
| Moss, AL; Ward, WF | 1 |
| Baudry, M; Lynch, G; Oliver, MW | 1 |
| Nanci, A; Smith, CE | 1 |
| Blum, JS; Cresswell, P; Marks, MS; Roche, PA | 1 |
| Korbelik, M; Osmak, M; Skrk, J; Suhar, A; Turk, V | 1 |
| Garcia de Herreros, A | 1 |
| Debrabant, A; Delplace, P | 1 |
| Kurita, Y; Nakao, H; Ogawa, H; Takamori, K; Tsuboi, R | 2 |
| Chen, L; Tai, PC | 1 |
| Kovács, J; Réz, G | 1 |
| Inui, K; Nishimoto, J; Okada, S; Yabuuchi, H | 1 |
| Miyoshi, K; Takauchi, S | 2 |
| Hara, T; Kato, Y; Umemoto, N | 1 |
| Conner, RL; Deyo, RA | 1 |
| Decker, SJ | 1 |
| Becker, EL; Gomez-Cambronero, J; Molski, TF; Sha'afi, RI | 1 |
| Guccione, MA; Livne, A; Mustard, JF; Packham, MA | 1 |
| Aktories, K; Jakobs, KH | 1 |
| Brass, LF; Shattil, SJ | 1 |
| Maeda, M; Neda, H; Niitsu, Y; Sone, H; Urushizaki, I; Watanabe, N; Yamauchi, N | 1 |
| Bevers, EM; Comfurius, P; Verhallen, PF; Zwaal, RF | 1 |
| McClain, DA; Olefsky, JM | 1 |
| Higuchi, N; Kajiwara, Y; Kambayashi, J; Mori, T; Sakon, M; Tanaka, T; Tsujinaka, T | 1 |
| Kaba, H; Keverne, EB | 1 |
| Baudry, M; Ivy, G; Larson, J; Lee, J; Lynch, G; Seubert, P; Shahi, K | 1 |
| Baudry, M; Ivy, G; Lynch, G; Seubert, P | 1 |
| Geratz, JD; Miskuff, RL; Sato, S; Tidwell, RR; Vonderfecht, SL; Wee, SB; Yolken, RH | 1 |
| Angelastro, MR; Bey, P; Mehdi, S; Wiseman, JS | 1 |
| Au, KS; Hsu, L; Morrison, M | 1 |
| Charlwood, PA; Chindemi, PA; Regoeczi, E | 1 |
| Flint, DJ; Jeffrey, IW; Mayer, RJ; Vernon, RG | 1 |
| Bureau, TE; Fosket, DE; Morejohn, LC | 1 |
| Presky, DH; Schonbrunn, A | 1 |
| Ballou, B; Hakala, TR; Ryser, HJ; Shen, WC | 1 |
| Cowell, GM; Danielsen, EM | 2 |
| Ando, Y; Imamura, S; Kannagi, R; Kitahara, A; Murachi, T; Saji, H; Yamagata, Y | 1 |
| Baudry, M; Hagan, JJ; Jensen, J; Lynch, GS; Morris, RG; Nadel, L | 1 |
| Beynon, RJ; Chetland, J; Galpin, IJ; Place, GA | 1 |
| Frankfater, A; Kozlowski, KA; Orawski, AT; Ortiz, R; Pagast, P; Schultz, RM; Varma-Nelson, P | 1 |
| Carpentier, JL; Hachiya, HL; King, GL | 1 |
| Dawson, G; Hancock, LW | 1 |
| Lapetina, EG; Ruggiero, M | 4 |
| Connolly, JA; Simard, G | 1 |
| Hozumi, N; Watanabe, M; Yoshikawa, M | 1 |
| Cunningham, DD; McKinley, DN; VanNostrand, W; Wiley, HS | 1 |
| Davis, WL; Jones, RG | 1 |
| Snyder, RA; Watt, KW; Wintroub, BU | 1 |
| Bakshian, S; Baldassare, JJ; Fisher, GJ; Knipp, MA | 1 |
| Goris, J; Merlevede, W; Waelkens, E | 1 |
| Connolly, TP; Dunn, WA; Hubbard, AL | 1 |
| Harford, JB; Klausner, RD; Rao, K; Weissman, AM | 1 |
| Carlino, JA; Niu, EM; Sherman, MR; Stevens, YW; Tuazon, FB | 1 |
| Hincke, MT; Tolnai, S | 1 |
| Horecker, BL; Melloni, E; Michetti, M; Pontremoli, S; Sacco, O; Salamino, F; Sparatore, B | 2 |
| Kosaki, G; Suzuki, K; Tanoue, K; Yamamoto, K; Yamazaki, H | 1 |
| Croall, DE; DeMartino, GN; Morrow, JS | 1 |
| Connold, AL; Evers, JV; Vrbová, G | 1 |
| Mykles, DL; Skinner, DM | 1 |
| Bokemeyer, C; Gabius, HJ; Hellmann, T; Schmoll, HJ | 1 |
| Davidson, S; Klagsbrun, M; Sasse, J; Shing, Y; Smith, JA; Smith, S; Sullivan, R | 1 |
| Billett, EE; Earl, RT; Hunneyball, IM; Mayer, RJ | 1 |
| Davies, KJ | 1 |
| Swanson, GJ; Vrbová, G | 1 |
| Ballard, FJ; Chandler, CS | 1 |
| Aikawa, M; Leech, JH; McKerrow, JH; Nagasawa, H; Rosenthal, PJ | 1 |
| Heidland, A; Kulzer, P; Leibold, J; Peter, G; Schaefer, RM; Teschner, M | 2 |
| Hazama, R; Kinoshita, N; Mori, M; Nagataki, S; Satoh, A; Takashima, H; Tsujihata, M; Yoshimura, T | 1 |
| Ito, M; Katunuma, N; Kominami, E; Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Toshima, K | 1 |
| Galjaard, H; Hoogeveen, AT; Sips, HJ; van Dongen, JM; Willemsen, R | 1 |
| Ahsan, A; Bain, DL; Ostrowski, LE; Pagast, P; Patel, A; Schultz, RM; Suthar, BP; Wong, C | 1 |
| Furuno, K; Goldberg, AL | 1 |
| Katsunuma, N; Morita, K; Nakanishi, A; Oka, M | 1 |
| Iizuka, H; Iwasaki, Y; Konno, H; Yamamoto, H; Yamamoto, T | 1 |
| Hibino, T; Sato, K; Yokozeki, H | 1 |
| Lentze, MJ; Naim, HY; Sterchi, EE | 1 |
| Chiou, WJ; Kovacic-Milivojević, B; LaPointe, MC; Reker, CE; Vedeckis, WV | 1 |
| Fisher, RR; Lubin, IM; Wu, LN | 1 |
| d'Azzo, A; Giudice, C; Hoogeveen, AT; Lijoi, S; Parenti, G; Strisciuglio, P | 1 |
| Cardelli, JA; Dimond, RL; Ebert, DL; Richardson, JM; Woychik, NA | 1 |
| Faragó, A; Seprõdi, J; Spät, A | 1 |
| Akagi, S; Masaki, R; Ogawa, R; Tashiro, Y; Yamamoto, A; Yoshimori, T | 1 |
| Bomford, A; Roberts, S | 1 |
| Khan, KM; Natori, Y; Okada, M; Sato, A | 1 |
| Hamilton, G; Karner, J; Kovats, E; Ollenschläger, G; Roth, E; Simmel, A | 1 |
| Karner, J; Kovats, E; Ollenschläger, G; Roth, E; Simmel, A | 1 |
| Schaudies, RP; Wray, HL | 1 |
| Alvarez-Azaustre, E; Hamilton, RT; Jang, YJ; Nilsen-Hamilton, M | 1 |
| Factorovich, Y; Puri, J | 1 |
| Bauer, A; Kirchner, H; Rutenfranz, I | 1 |
| Grandt, R; Jakobs, KH | 1 |
| Blum, JS; Cresswell, P | 1 |
| Klenk, HD; Rott, R; Tashiro, M | 1 |
| Lehmann, A | 1 |
| Fischer, JE; Hasselgren, PO; Hummel, RP; James, JH; Warner, BW | 2 |
| Christen, P; Flückiger, J | 1 |
| Hoppe, W; Kresse, H; Rauch, U | 1 |
| Catalfamo, JL; Fareed, J; Fenton, JW; Pouliott, C; Witting, JI | 1 |
| Chang, VK; Kaldany, RR; Maccabee, PJ; Stracher, A; Valderrama, R | 1 |
| Bridges, KR; Hoffman, KE | 1 |
| Cakiroglu, AG; Jackson, JF; Marks, PA; Melloni, E; Michetti, M; Pontremoli, S; Rifkind, RA; Sacco, O | 1 |
| Coffey, RJ; Kost, LJ; LaRusso, NF; Lyons, RM; Moses, HL | 1 |
| Currie, DD; Garte, SJ; Troll, W | 1 |
| Endo, N; Hara, T; Kato, Y; Kishida, K; Saito, M; Takeda, Y; Umemoto, N | 2 |
| Lindquist, RN; McKerrow, J; Petitt, M; Senft, AW | 1 |
| Iizuka, H; Iwasaki, Y; Kadoya, S; Yamamoto, T | 1 |
| Kooistra, T; Lloyd, JB | 3 |
| Ahsan, A; Ostrowski, LE; Pagast, P; Persky, B; Schultz, RM | 1 |
| Danzo, BJ | 1 |
| Taurog, A; Yoshinari, M | 2 |
| Abramovitz, AS; Margolis, JW; Wagner, BJ | 1 |
| Dluzewski, AR; Gratzer, WB; Rangachari, K; Wilson, RJ | 1 |
| Ikeno, K; Ikeno, T; Ishiguro, I; Kuzuya, H | 1 |
| Aerts, JF; Barranger, JA; Ginns, EI; Jonsson, LM; Murray, GJ; Schram, AW; Sorrell, SH; Strijland, A; Tager, JM | 1 |
| Goto, I; Kuroiwa, Y; Shinno, N | 1 |
| Itoh, N; Okada, Y; Okamoto, H; Teno, N; Tsuboi, S | 1 |
| Davis, JL; Pico, RM | 1 |
| Doherty, FJ; Mayer, RJ; Wassell, JA | 1 |
| Kato, H; Naito, H; Noguchi, T; Takahashi, A; Takahashi, S | 1 |
| Beertsen, W; Everts, V | 1 |
| Beckenbauer, T; Kugler, P | 1 |
| Ishii, S; Murao, S; Numakunai, T; Yokosawa, H | 1 |
| Badalamente, MA; Hurst, LC; Paul, SB; Stracher, A | 1 |
| Kasayama, S; Kishimoto, S; Matsumoto, K; Nakao, M; Nishizawa, Y; Noma, K; Sato, B | 1 |
| Bridges, KR | 1 |
| Ruda, EM; Scrutton, MC | 1 |
| Ahlberg, J; Glaumann, H | 1 |
| Cox, CA; Rao, GH; White, JG | 1 |
| Nakagawa, H; Tsurufuji, S; Watanabe, K | 1 |
| Bression, D; Le Dafniet, M; Michard, M; Pagesy, P; Peillon, F | 1 |
| Kugler, P; Miki, A | 1 |
| Decker, RS; Ridout, RM; Wildenthal, K | 1 |
| Fukuyo, T; Hara, S; Hayasaka, S; Mizuno, K; Nakazawa, M | 1 |
| Beynon, RJ; Ning, MC | 1 |
| Ishibashi, M; Miyazaki, H; Mizuguchi, S; Takayama, H; Tanaka, W; Umezawa, H; Watanabe, K; Yamashita, K | 1 |
| Kirwin, P; Mayer, RJ; O'Hare, M; Razooki-Hasan, H; White, DA; Wilde, C | 1 |
| Capony, F; Morisset, M; Rochefort, H | 1 |
| Dresden, MH; Xu, YZ | 1 |
| Pick, E; Toper, R | 1 |
| Ascoli, M; Segaloff, DL | 1 |
| Ahlberg, J; Berkenstam, A; Glaumann, H; Henell, F | 3 |
| Gagnon, C; Veeraragavan, K | 1 |
| Hsieh, LC; Markland, FS; Su, C | 1 |
| Bernstein, PL; Etlinger, JD; Ludemann, R; Zeman, RJ | 1 |
| Ichikawa, S; Murao, S; Oda, K; Shibata, T; Takehara, Y; Tamada, H | 2 |
| Faraday, R; Lynch, G; Stäubli, U | 1 |
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8 review(s) available for leupeptin and leupeptins
| Article | Year |
|---|---|
Transport and expression of HLA class-II glycoproteins.
Topics: B-Lymphocytes; Cell Line; Endocytosis; Endopeptidases; Gene Expression Regulation; Genes, MHC Class II; HLA-D Antigens; Humans; Leupeptins; Membrane Glycoproteins; Protein Processing, Post-Translational | 1990 |
Quantitative aspects of cellular autophagocytosis. Morphometric and cell fractionation studies.
Topics: Animals; Autophagy; Cell Compartmentation; Cell Fractionation; Chloroquine; Leupeptins; Liver; Lysosomes; Male; Methylamines; Pancreas; Phagocytosis; Rats; Seminal Vesicles; Vacuoles; Vinblastine | 1989 |
"Defective" receptors in steroid-resistant conditions may be proteolytic artifacts.
Topics: Animals; Breast; Breast Neoplasms; Centrifugation, Density Gradient; Cytosol; Drug Resistance; Endometrium; Endopeptidases; Female; Humans; Kidney; Leukemia; Leupeptins; Liver; Lysine; Macromolecular Substances; Male; Molybdenum; Osmolar Concentration; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Substrate Specificity; Ultracentrifugation; Uterine Neoplasms | 1986 |
Calcium-dependent proteolytic stimulation of adenylate cyclase in platelets from spontaneously hypertensive rats.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Calcium; Calmodulin; Cyclic AMP; Enzyme Activation; Epinephrine; Humans; Hypertension; Leupeptins; Peptide Hydrolases; Platelet Aggregation; Prostaglandins E; Rats; Rats, Inbred Strains; Renin | 1984 |
Are proteinase inhibitors potentially useful in tumor therapy?
Topics: Animals; Antipain; Aprotinin; Blood Coagulation; Cathepsin B; Cathepsin D; Cathepsins; Endopeptidases; Humans; Leupeptins; Microbial Collagenase; Neoplasms; Pancreatic Elastase; Plasminogen Activators; Protease Inhibitors | 1982 |
Calpain inhibitors as therapeutic agents in nerve and muscle degeneration.
Topics: Animals; Glycoproteins; Hair Cells, Auditory; Haplorhini; Hearing Loss, Noise-Induced; Leupeptins; Mice; Mice, Inbred C57BL; Muscular Dystrophy, Animal; Nerve Degeneration; Spiral Ganglion | 1999 |
Peroxisome degradation in mammals.
Topics: Animals; Arachidonate 15-Lipoxygenase; Autophagy; Cells, Cultured; Half-Life; Humans; Hypolipidemic Agents; Leupeptins; Mammals; Peroxisomes; Protease La; Ubiquitination | 2011 |
Natural products from thioester reductase containing biosynthetic pathways.
Topics: Alkaloids; Azabicyclo Compounds; Benzodiazepinones; Biological Products; Biosynthetic Pathways; Cyclization; Depsipeptides; Dipeptides; Indoles; Lactams; Leupeptins; Lysine; Multigene Family; Peptide Synthases; Polyketide Synthases; Protein Domains | 2018 |
885 other study(ies) available for leupeptin and leupeptins
| Article | Year |
|---|---|
Giant sarcoplasmic reticulum vesicles: a study of membrane morphogenesis.
Topics: Animals; Antipain; Aprotinin; Calcium-Transporting ATPases; Crystallization; Egtazic Acid; Lanthanum; Leupeptins; Liposomes; Membrane Fusion; Membrane Proteins; Microscopy, Electron; Morphogenesis; Muscle Proteins; Proteolipids; Rabbits; Sarcoplasmic Reticulum; Temperature; Vanadates | 1992 |
Differences in alpha 2u-globulins increased in male rat kidneys following treatment with several alpha 2u-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type-alpha 2u-globulin.
Topics: Alpha-Globulins; Animals; Chlorobenzenes; Cyclohexanones; Cyclohexenes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Kidney; Leucine; Leupeptins; Limonene; Male; Naphthalenes; Octanes; Rats; Rats, Sprague-Dawley; Terpenes | 1992 |
Protease activities in carp retina.
Topics: Amino Acid Sequence; Animals; Carps; Coumarins; Endopeptidases; Hydrogen-Ion Concentration; Leucine; Leupeptins; Molecular Sequence Data; Peptides; Phenanthrolines; Protease Inhibitors; Retina; Serine Endopeptidases; Tosyllysine Chloromethyl Ketone | 1992 |
Synthesis and brush border expression of intrinsic factor-cobalamin receptor from rat renal cortex.
Topics: Animals; Chloroquine; Chromatography, Liquid; Culture Techniques; Electrophoresis, Polyacrylamide Gel; Intrinsic Factor; Kidney Cortex; Leupeptins; Male; Microvilli; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Vitamin B 12 | 1992 |
Separation, purification and N-terminal sequence analysis of a novel leupeptin-sensitive serine endopeptidase present in chemically induced rat mammary tumour.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Benzoylarginine Nitroanilide; Chromatography, Gel; Electrophoresis; Enzyme Activation; Enzyme Stability; Female; Hydrogen-Ion Concentration; Hydrolysis; Isoelectric Point; Leupeptins; Mammary Neoplasms, Experimental; Methylnitrosourea; Molecular Sequence Data; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Substrate Specificity; Tissue Extracts | 1992 |
Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events.
Topics: Leupeptins; Models, Biological; Murine hepatitis virus; Peptide Fragments; Precipitin Tests; Protein Biosynthesis; Protein Precursors; Protein Processing, Post-Translational; Reading Frames; Time Factors; Viral Proteins | 1992 |
Metabolism of omega-conotoxin-sensitive voltage-operated calcium channels in human neuroblastoma cells: modulation by cell differentiation and anti-channel antibodies.
Topics: Antibodies; Calcium Channels; Cell Differentiation; Chloroquine; Electrophysiology; Humans; Leupeptins; Neuroblastoma; omega-Conotoxins; Peptides, Cyclic; Temperature | 1992 |
Role of cathepsin D in antigen presentation of ovalbumin.
Topics: Animals; Antigen-Presenting Cells; Cathepsin B; Cathepsin D; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Histocompatibility Antigens Class II; In Vitro Techniques; Interleukin-2; Leupeptins; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Ovalbumin; Pepstatins; T-Lymphocytes | 1992 |
Endocytosis and lysosomal delivery of tissue plasminogen activator-inhibitor 1 complexes in Hep G2 cells.
Topics: Ammonium Chloride; beta-N-Acetylhexosaminidases; Carcinoma, Hepatocellular; Chloroquine; Endocytosis; Humans; Kinetics; Leupeptins; Liver Neoplasms; Lysosomes; Pepstatins; Plasminogen Activator Inhibitor 1; Primaquine; Recombinant Proteins; Subcellular Fractions; Tissue Plasminogen Activator; Tumor Cells, Cultured | 1992 |
Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain.
Topics: Aging; Alzheimer Disease; Animals; Brain; Dolichols; Endopeptidases; Humans; Immunologic Techniques; Intermediate Filaments; Leucine; Leupeptins; Lipofuscin; Macaca fascicularis; Male; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Ubiquitins | 1992 |
Regulated expression of the tyrosine hydroxylase gene by membrane depolarization. Identification of the responsive element and possible second messengers.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Cell Line; Chloramphenicol O-Acetyltransferase; Drug Interactions; Enzyme Activation; Gene Expression Regulation, Enzymologic; Ionomycin; Leupeptins; Membrane Potentials; PC12 Cells; Plasmids; Protein Kinase C; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Second Messenger Systems; Sphingosine; Transcription, Genetic; Tyrosine 3-Monooxygenase; Veratridine | 1992 |
Different patterns of protein kinase C redistribution mediated by alpha 1-adrenoceptor stimulation and phorbol ester in rat isolated left ventricular papillary muscle.
Topics: Adrenergic alpha-Agonists; Animals; Leucine; Leupeptins; Male; Myocardial Contraction; Papillary Muscles; Phenylephrine; Phorbol 12,13-Dibutyrate; Protease Inhibitors; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1992 |
Modified immunoradiometric assay of parathyroid hormone-related protein: clinical application in the differential diagnosis of hypercalcemia.
Topics: Aprotinin; Diagnosis, Differential; Drug Stability; Humans; Hypercalcemia; Immunoradiometric Assay; Leupeptins; Neoplasms; Parathyroid Hormone-Related Protein; Peptide Fragments; Proteins | 1992 |
Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.
Topics: 1-Methyl-3-isobutylxanthine; Aprotinin; Blotting, Northern; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; DNA Replication; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Leupeptins; Male; Pentoxifylline; Phenylmethylsulfonyl Fluoride; Prostatic Neoplasms; RNA, Neoplasm; Theophylline; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Protease inhibitors as a model for NCL disease, with special emphasis on the infantile and adult forms.
Topics: Animals; Aprotinin; Ceroid; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dogs; Humans; Leupeptins; Lipofuscin; Lysosomes; Neuronal Ceroid-Lipofuscinoses; Purkinje Cells; Rats; Rats, Inbred Strains | 1992 |
Phenotypic variation of surface antigenic determinants in Trichomonas vaginalis detected by monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Protozoan; Antigenic Variation; Antigens, Protozoan; Antigens, Surface; Epitopes; Fluorescent Antibody Technique; Hybridomas; Immunoblotting; Leupeptins; Phenotype; Trichomonas vaginalis | 1992 |
Alterations of the levels of glycoproteins Ib-IX and IIb-IIIa in platelets stored at 22 degrees C.
Topics: Antibodies, Monoclonal; Aprotinin; Blood Platelets; Blood Preservation; Cold Temperature; Humans; Leupeptins; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Ristocetin | 1992 |
Uptake, intracellular transport, and degradation of polyethylene glycol-modified asialofetuin in hepatocytes.
Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Biological Transport; Cells, Cultured; Chloroquine; Fetuins; Kinetics; Kupffer Cells; Leupeptins; Liver; Polyethylene Glycols; Rats; Time Factors | 1992 |
Unique expression of von Willebrand factor by type IIA von Willebrand's disease endothelial cells.
Topics: Blood Platelets; Blotting, Western; Cells, Cultured; Edetic Acid; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Ethylmaleimide; Female; Humans; Leupeptins; Male; Molecular Weight; Pedigree; von Willebrand Diseases; von Willebrand Factor | 1992 |
Calcium-activated potassium transport and high molecular weight forms of calpromotin.
Topics: Biological Transport; Blood Proteins; Blotting, Western; Calcium; Cells, Cultured; Chromatography, High Pressure Liquid; Cytoplasm; Erythrocyte Membrane; Humans; Iodoacetates; Iodoacetic Acid; Leupeptins; Molecular Weight; Potassium | 1992 |
Recovery after delayed nerve repair: influence of a pharmacologic adjunct in a primate model.
Topics: Animals; Axons; Calpain; Cebus; Leupeptins; Median Nerve; Muscles; Muscular Atrophy; Nerve Regeneration; Neural Conduction; Time Factors | 1992 |
Effect of lysosomotropic agents on the taurocholate-stimulated biliary excretion of horseradish peroxidase.
Topics: Acid Phosphatase; Animals; Bile Acids and Salts; Biliary Tract; Chloroquine; Horseradish Peroxidase; Leupeptins; Lysosomes; Male; Rats; Rats, Wistar; Taurocholic Acid | 1992 |
Assembly and secretion of fibrinogen. Degradation of individual chains.
Topics: Ammonium Chloride; Animals; Cell Line; Chickens; Chloroquine; Fibrinogen; Humans; Kinetics; Leupeptins; Liver; Lysosomes; Macromolecular Substances; Methionine; Sulfur Radioisotopes; Transfection; Tumor Cells, Cultured | 1992 |
The fertilization and development of mouse oocytes following cortical granule discharge in the presence of a protease inhibitor.
Topics: Animals; Blastocyst; Calcimycin; Culture Techniques; Embryo, Mammalian; Embryonic and Fetal Development; Exocytosis; Female; Fertilization; Fertilization in Vitro; Fluorescent Dyes; Insemination, Artificial; Leupeptins; Mice; Oocytes; Superovulation | 1992 |
Opsonized zymosan decreases cytoplasmic motility of alveolar macrophages in dogs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Aminopeptidases; Animals; Calcium; Captopril; Cells, Cultured; Cytoplasm; Dogs; Indomethacin; Leucine; Leupeptins; Macrophages; Phagocytosis; Pulmonary Alveoli; Superoxide Dismutase; Zymosan | 1992 |
Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses.
Topics: Amino Acid Sequence; Animals; Calcimycin; Calpain; Cataract; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Culture Techniques; Cysteine Proteinase Inhibitors; Dipeptides; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Lens, Crystalline; Leucine; Leupeptins; Molecular Sequence Data; Rats; Rats, Sprague-Dawley | 1992 |
A 1H-NMR study of the interactions between rat tissue kallikrein and two peptide inhibitors.
Topics: Amino Acid Sequence; Animals; Kallikreins; Leupeptins; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Sequence Data; Protein Conformation; Rats; Submandibular Gland | 1992 |
Enhanced ex vivo proteolysis of plasma von Willebrand factor in disseminated intravascular coagulation.
Topics: alpha-2-Antiplasmin; Antifibrinolytic Agents; Disseminated Intravascular Coagulation; Edetic Acid; Ethylmaleimide; Fibrinolysin; Humans; Leupeptins; Multienzyme Complexes; Protein Conformation; von Willebrand Factor | 1992 |
The effect of protease inhibitors, leupeptin and E64d, on differentiation of C2C12 myoblasts in tissue culture.
Topics: Animals; Calcium; Calpain; Cell Differentiation; Cell Fusion; Culture Techniques; Leucine; Leupeptins; Mice; Muscles; Protease Inhibitors | 1992 |
A block in degradation of MHC class II-associated invariant chain correlates with a reduction in transport from endosome carrier vesicles to the prelysosome compartment.
Topics: Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; Biological Transport; Endocytosis; Histocompatibility Antigens Class II; Humans; Leupeptins; Tumor Cells, Cultured | 1992 |
Proteolytic activation of a single-chain precursor of hepatocyte growth factor by extracellular serine-protease.
Topics: Animals; Autoradiography; Cell Division; Cell Line; CHO Cells; Cricetinae; Cysteine; DNA; Electrophoresis, Polyacrylamide Gel; Fibrinolysin; Hepatocyte Growth Factor; Humans; Leupeptins; Liver; Lung; Methionine; Plasmids; Protein Precursors; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Serine Endopeptidases; Sulfur Radioisotopes; Tissue Plasminogen Activator; Transfection; Urokinase-Type Plasminogen Activator | 1992 |
Identification and localization of a cysteinyl residue critical for the trypsin-like catalytic activity of the proteasome.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Chymotrypsin; Cyanogen Bromide; Cysteine; Cysteine Endopeptidases; Erythrocytes; Ethylmaleimide; Humans; Kinetics; Leupeptins; Macromolecular Substances; Molecular Sequence Data; Multienzyme Complexes; Myocardium; Peptide Fragments; Peptide Mapping; Proteasome Endopeptidase Complex; Trypsin | 1992 |
Turnover of peroxisomal vesicles by autophagic proteolysis in cultured fibroblasts from Zellweger patients.
Topics: Adenine; Autophagy; Cell Line; Fibroblasts; Fluorescent Antibody Technique; Humans; Hydrolases; Leupeptins; Lysosomes; Membrane Proteins; Microbodies; Zellweger Syndrome | 1992 |
Calcium-binding protein regucalcin increases calcium-independent proteolytic activity in rat liver cytosol.
Topics: Animals; Cadmium; Calcium; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Cytosol; Dose-Response Relationship, Drug; Endopeptidases; Intracellular Signaling Peptides and Proteins; Leupeptins; Liver; Male; Rats; Sulfotransferases; Zinc | 1992 |
Serum proteases alter the antigenicity of peptides presented by class I major histocompatibility complex molecules.
Topics: Animals; Antigen-Presenting Cells; Cells, Cultured; Cyanogen Bromide; Endopeptidases; In Vitro Techniques; Leucine; Leupeptins; Mice; Molecular Weight; Ovalbumin; Peptides | 1992 |
Stimulation-enhanced 3-O-methylglucose efflux from the frog sartorius: kinetics and properties of the system.
Topics: 3-O-Methylglucose; Animals; Calcium; Cycloheximide; Dipeptides; Electric Stimulation; Humans; Kinetics; Leupeptins; Male; Methylglucosides; Muscles; Phloretin; Rana pipiens; Tetradecanoylphorbol Acetate | 1992 |
Intraventricular infusion of leupeptin decreases Bmax of the D2 receptor in the striatum of young rats.
Topics: Animals; Corpus Striatum; Injections, Intraventricular; Leupeptins; Male; Protein Binding; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1992 |
Characterization of different proteolytic activities in Trypanosoma brucei brucei.
Topics: Amino Acid Sequence; Animals; Chromatography, Affinity; Chromatography, High Pressure Liquid; Dithiothreitol; Endopeptidases; Glycoproteins; Hydrogen-Ion Concentration; Kinetics; Leucine; Leupeptins; Molecular Sequence Data; Protease Inhibitors; Trypanosoma brucei brucei | 1992 |
Lymphoproliferative activity of Pseudomonas exotoxin A is dependent on intracellular processing and is associated with the carboxyl-terminal portion.
Topics: ADP Ribose Transferases; Animals; Antigen-Presenting Cells; Bacterial Toxins; Cathepsin D; Endopeptidases; Exotoxins; In Vitro Techniques; Leupeptins; Lymphocyte Activation; Mice; Mice, Inbred Strains; Pepstatins; Peptide Mapping; Protein Processing, Post-Translational; Pseudomonas aeruginosa Exotoxin A; T-Lymphocytes; Thymus Gland; Virulence Factors | 1992 |
Aminopeptidase activity of an antitumor antibiotic, C-1027.
Topics: Aminoglycosides; Aminopeptidases; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Apoproteins; Carcinoma, Ehrlich Tumor; Cell Survival; DNA, Neoplasm; Enediynes; Leucine; Leupeptins; Microsomes; Oligopeptides; Peptides; Proteins; Substrate Specificity; Swine; Tumor Cells, Cultured; Ultraviolet Rays | 1992 |
Effect of platelet calpain on normal T-lymphocyte CD43: hypothesis of events in the Wiskott-Aldrich syndrome.
Topics: Antigens, CD; Blood Platelets; Calcium; Calpain; Humans; Immunoblotting; Leukosialin; Leupeptins; Models, Biological; N-Acetylneuraminic Acid; Neuraminidase; Platelet Membrane Glycoproteins; Sialic Acids; Sialoglycoproteins; Substrate Specificity; T-Lymphocytes | 1992 |
Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell lines.
Topics: Antipain; Freeze Fracturing; Humans; Intercellular Junctions; Leupeptins; Protein Precursors; Protein Processing, Post-Translational; Tumor Cells, Cultured | 1992 |
Regulation of the functional expression of hexose transporter GLUT-1 by glucose in murine fibroblasts: role of lysosomal degradation.
Topics: 3T3 Cells; Animals; Biological Transport; Cell Compartmentation; Chloroquine; Glucose; Hexoses; In Vitro Techniques; Leupeptins; Lysosomes; Membrane Proteins; Mice; Monosaccharide Transport Proteins | 1992 |
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Biotin; Cell Membrane; Endothelium, Vascular; Humans; Leupeptins; Lysosomes; Molecular Weight; Peptide Fragments; Umbilical Veins | 1992 |
Role of hepatic lysosomes in the degradation of metallothionein.
Topics: Animals; Cathepsins; Electrophoresis, Polyacrylamide Gel; Leucine; Leupeptins; Liver; Lysosomes; Male; Metallothionein; Pepstatins; Rats; Rats, Inbred Strains | 1992 |
Effects of heparin on osteoclast activity.
Topics: Animals; Bone Resorption; Cells, Cultured; Chickens; Chondroitin Sulfates; Culture Media; Cyclosporine; Dextran Sulfate; Heparin; Histamine; Leupeptins; Osteoclasts; Phenytoin; Protamines; Rats | 1992 |
Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate.
Topics: Amyloid beta-Protein Precursor; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leucine; Leupeptins; Molecular Weight; Peptide Fragments; Transfection | 1992 |
The possible involvement of trypsin-like enzymes in germination of spores of Bacillus cereus T and Bacillus subtilis 168.
Topics: Arginine; Bacillus cereus; Bacillus subtilis; Benzoylarginine Nitroanilide; Chromogenic Compounds; Hot Temperature; Hydrolysis; Leupeptins; Spores, Bacterial; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Trypsin | 1991 |
Morphological and functional changes in the enterocyte induced by fructose.
Topics: Aminopeptidases; Animals; Apolipoprotein A-I; CD13 Antigens; Cell Fractionation; Electrophoresis, Polyacrylamide Gel; Fructose; Glycosylation; Golgi Apparatus; Intestinal Mucosa; Leupeptins; Mannose; Membrane Proteins; Microscopy, Electron; Microvilli; Organ Culture Techniques; Swine | 1991 |
Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Aprotinin; Brain; Endopeptidases; Female; Humans; Kallikreins; Leupeptins; Male; Middle Aged; Molecular Sequence Data; Peptide Hydrolases; Prolyl Oligopeptidases; Serine Endopeptidases | 1990 |
Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes.
Topics: Animals; Cell Survival; Chick Embryo; Chloroquine; Curare; Cycloheximide; Dactinomycin; Ganglia, Spinal; Gene Expression; Genotype; Leupeptins; Microscopy, Electron; Motor Neurons; Protein Biosynthesis; Puromycin; RNA; Spinal Cord | 1990 |
Different roles for thiol and aspartyl proteases in antigen presentation of ovalbumin.
Topics: Animals; Antigen-Presenting Cells; Aspartic Acid Endopeptidases; B-Lymphocytes; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Epitopes; H-2 Antigens; In Vitro Techniques; Leupeptins; Macrophages; Mice; Ovalbumin; Pepstatins; Peptide Fragments; T-Lymphocytes, Helper-Inducer | 1990 |
Enhanced proliferation of murine T cell lines following interaction of Poly(Glu60, Phe40) (GPhe) and antigen-presenting accessory cells. III. Possible mechanisms responsible for activity of GPhe.
Topics: Animals; Antibodies; Antigen-Presenting Cells; Cell Division; Cell Line; Cell Membrane; Culture Media; Epitopes; Interleukin-1; Leupeptins; Lymphocyte Activation; Mice; Phenylalanine; Polyglutamic Acid; T-Lymphocytes; Time Factors | 1990 |
Soluble fibrin preparations inhibit the reaction of plasmin with alpha 2-macroglobulin. Comparison with alpha 2-antiplasmin and leupeptin.
Topics: alpha-Macroglobulins; Chromogenic Compounds; Cyanogen Bromide; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Fibrinolysin; Humans; Kinetics; Leupeptins; Oligopeptides | 1991 |
Cysteine proteinase inhibitors and bleomycin-sensitive and -resistant cells.
Topics: Bleomycin; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cysteine Proteinase Inhibitors; Drug Resistance; Drug Synergism; Head and Neck Neoplasms; Leucine; Leupeptins; Tumor Cells, Cultured | 1991 |
Effects of inhibitors on proteinase activities in gels following isoelectric focussing.
Topics: Amino Acid Sequence; Animals; Aprotinin; Endopeptidases; Isoelectric Focusing; Leupeptins; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Rats; Submandibular Gland; Trypsin Inhibitors | 1990 |
The selective role of cathepsins B and D in the lysosomal degradation of endogenous and exogenous proteins.
Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Cathepsin B; Cathepsin D; Dipeptides; Fetuins; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Leupeptins; Liver; Lysosomes; Male; Pepstatins; Proteins; Rats; Rats, Inbred Strains; Thiocyanates | 1991 |
Reversal of rapid axonal transport at a lesion: leupeptin inhibits reversed protein transport, but does not inhibit reversed organelle transport.
Topics: Animals; Axonal Transport; Axons; Leupeptins; Methionine; Nerve Crush; Nerve Tissue Proteins; Organelles; Reference Values; Sciatic Nerve; Spinal Cord; Sulfur Radioisotopes; Xenopus laevis | 1991 |
Effect of neutral endopeptidase inhibition on substance-P-induced increase in short-circuit current of canine cultured tracheal epithelium.
Topics: Amiloride; Animals; Anti-Bacterial Agents; Biological Transport, Active; Captopril; Cells, Cultured; Complement C1; Dogs; Dose-Response Relationship, Drug; Electric Conductivity; Female; Furosemide; Glycopeptides; In Vitro Techniques; Ion Channel Gating; Leucine; Leupeptins; Male; Membrane Potentials; Neprilysin; Substance P; Time Factors; Trachea | 1991 |
Use of antibody/peptide constructs of direct antigenic peptides to T cells: evidence for T cell processing and presentation.
Topics: Antigen-Antibody Complex; Antigen-Presenting Cells; Antigens, Bacterial; Chloroquine; Clone Cells; Dose-Response Relationship, Immunologic; Humans; In Vitro Techniques; Leupeptins; Lymphocyte Activation; Peptides; T-Lymphocytes; Tetanus Toxoid | 1992 |
The ability and inability of ATP to stop aluminum from reducing the sodium efflux in unpoisoned barnacle muscle fibers.
Topics: Adenosine Triphosphate; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Biological Transport; Chlorides; Drug Antagonism; Leupeptins; Magnesium Chloride; Myofibrils; Pepstatins; Sodium; Thoracica | 1992 |
Dysfunction of nonadrenergic noncholinergic inhibitory system after antigen inhalation in actively sensitized cat airways.
Topics: Administration, Inhalation; Airway Resistance; Animals; Antigens; Ascaris; Bronchi; Cats; Electric Stimulation; Immunization; Leupeptins; Nervous System; Neural Inhibition; Respiratory Hypersensitivity; Serine Proteinase Inhibitors; Vasoactive Intestinal Peptide | 1992 |
Leupeptin and ammonium chloride inhibit intrinsic factor mediated transcytosis of [57Co]cobalamin across polarized renal epithelial cells.
Topics: Ammonium Chloride; Animals; Autoradiography; Biological Transport; Cells, Cultured; Chromatography, Gel; Cobalt Radioisotopes; Electrophoresis, Polyacrylamide Gel; Epithelium; Intrinsic Factor; Iodine Radioisotopes; Kidney; Leupeptins; Molecular Weight; Opossums; Rats; Vitamin B 12 | 1992 |
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
Topics: Ammonium Chloride; Amyloid; Amyloid beta-Protein Precursor; Base Sequence; Cell Line; Endopeptidases; Humans; Leupeptins; Lysosomes; Molecular Sequence Data; Mutagenesis; Peptide Fragments; Transfection | 1992 |
Acid proteinases of the fore-gut in metamorphosing tadpoles of Rana catesbeiana.
Topics: Animals; Chromatography, Agarose; Digestive System; Endopeptidases; Hydrogen-Ion Concentration; Larva; Leupeptins; Molecular Weight; Pepstatins; Rana catesbeiana | 1991 |
Calcium-dependent and calcium-independent protease activities in skeletal muscle during sepsis.
Topics: Animals; Bacteremia; Calcium; Calpain; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Escherichia coli Infections; Leupeptins; Male; Muscles; Rats; Rats, Inbred Strains | 1991 |
Catalytic subunits of the multicatalytic proteinase.
Topics: Animals; Binding Sites; Cysteine Endopeptidases; Ethylmaleimide; Leupeptins; Liver; Macromolecular Substances; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Substrate Specificity; Trypsin | 1991 |
Lysosomotropic agents induce morphological and functional changes in human muscle cells in vitro.
Topics: Cells, Cultured; Chloroquine; Histocytochemistry; Humans; Leupeptins; Lysosomes; Microscopy, Electron; Muscles; Propranolol | 1991 |
Inhibitory effects of recombinant human cystatin C on human coronaviruses.
Topics: Antiviral Agents; Cathepsin B; Cells, Cultured; Coronaviridae; Cycloheximide; Cystatin C; Cystatins; Escherichia coli; Humans; Leupeptins; Papain; Recombinant Proteins; Virus Replication | 1991 |
Atrial natriuretic factor inhibits ciliary motility in cultured rabbit tracheal epithelium.
Topics: Animals; Atrial Natriuretic Factor; Captopril; Cells, Cultured; Cilia; Enzyme Inhibitors; Epithelium; Glycopeptides; Indomethacin; Kinetics; Leucine; Leupeptins; Male; Masoprocol; Methylene Blue; Movement; Piroxicam; Purinones; Rabbits; Thiorphan; Trachea | 1991 |
Intracellular catabolism of radiolabeled anti-CD3 antibodies by leukemic T cells.
Topics: Ammonium Chloride; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Autoradiography; CD3 Complex; Endocytosis; Humans; In Vitro Techniques; Leukemia-Lymphoma, Adult T-Cell; Leupeptins; Molecular Weight; Monensin; Peptide Fragments; Receptors, Antigen, T-Cell; T-Lymphocytes; Tumor Cells, Cultured | 1991 |
The N-glycan processing in HT-29 cells is a function of their state of enterocytic differentiation. Evidence for an atypical traffic associated with change in polypeptide stability in undifferentiated HT-29 cells.
Topics: 1-Deoxynojirimycin; alpha-Mannosidase; Biological Transport; Cell Differentiation; Colon; Colonic Neoplasms; Glucosamine; Humans; In Vitro Techniques; Leupeptins; Mannosidases; Membrane Glycoproteins; Monensin; Polysaccharides; Protein Processing, Post-Translational; Tumor Cells, Cultured | 1991 |
Inhibition of proteolysis protects hippocampal neurons from ischemia.
Topics: Animals; Calpain; Cerebral Ventricles; Electrophysiology; Endopeptidases; Evoked Potentials; Gerbillinae; Hippocampus; Hypoxia; Infusions, Parenteral; Ischemic Attack, Transient; Leupeptins; Neurons; Spectrin; Synapses | 1991 |
Proteolytic processing of the insulin receptor beta subunit is associated with insulin-induced receptor down-regulation.
Topics: Animals; Blotting, Western; Cells, Cultured; Chloroquine; Cycloheximide; Cysteine Endopeptidases; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Insulin; Insulin Antagonists; Leucine; Leupeptins; Mice; Peptide Fragments; Receptor, Insulin | 1991 |
The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitors.
Topics: Animals; Antigen-Presenting Cells; B-Lymphocytes; Hybridomas; In Vitro Techniques; Leupeptins; Mice; Ovalbumin; Peptides; Protease Inhibitors; Spleen; T-Lymphocytes | 1991 |
Direct evidence for spatial and temporal regulation of transforming growth factor beta 1 expression during cutaneous wound healing.
Topics: Animals; Antibodies; Blister; Edetic Acid; Gene Expression Regulation; Humans; Immunohistochemistry; Leupeptins; Skin; Skin Physiological Phenomena; Swine; Transforming Growth Factor beta; Wound Healing | 1991 |
Diastereotopic covalent binding of the natural inhibitor leupeptin to trypsin: detection of two interconverting hemiacetals by solution and solid-state NMR spectroscopy.
Topics: Binding Sites; Hydrogen-Ion Concentration; Leupeptins; Macromolecular Substances; Magnetic Resonance Spectroscopy; Serine Proteinase Inhibitors; Solutions; Trypsin | 1991 |
Activation of intracellular calcium-activated neutral proteinase in erythrocytes and its inhibition by exogenously added inhibitors.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blood Proteins; Calcimycin; Calcium; Calpain; Enzyme Activation; Erythrocytes; Female; In Vitro Techniques; Leucine; Leupeptins; Membrane Proteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Rabbits | 1991 |
Effects of synthetic peptides and protease inhibitors on the interaction of a human ovarian cancer cell line (NIH:OVCAR-3) with a reconstituted basement membrane (Matrigel).
Topics: Amides; Amino Acid Sequence; Aminocaproates; Antineoplastic Agents; Benzamidines; Biocompatible Materials; Cell Adhesion; Cell Line; Chemotaxis; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Female; Glycoproteins; Humans; In Vitro Techniques; Laminin; Leupeptins; Metalloendopeptidases; Molecular Sequence Data; Neoplasm Invasiveness; Oligopeptides; Ovarian Neoplasms; Pepstatins; Polyamines; Protease Inhibitors; Proteoglycans; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Tyrosine | 1991 |
Effects of hypoxia and reoxygenation on the conversion of xanthine dehydrogenase to oxidase in Chinese hamster V79 cells.
Topics: Allopurinol; Animals; Calcium; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Glucose; Hypoxia; Leupeptins; Lipid Peroxidation; Verapamil; Xanthine Dehydrogenase; Xanthine Oxidase | 1991 |
Studies on the antimalarial mode of action of quinoline-containing drugs: time-dependence and irreversibility of drug action, and interactions with compounds that alter the function of the parasite's food vacuole.
Topics: Ammonium Chloride; Animals; Antimalarials; Drug Combinations; Drug Interactions; Hydrogen-Ion Concentration; Leupeptins; Plasmodium falciparum; Quinolines; Time Factors | 1991 |
Natural killer cell activity of rhesus macaques against retrovirus-pulsed CD4+ target cells.
Topics: Animals; CD4 Antigens; CD4-Positive T-Lymphocytes; Cell Line; Cytotoxicity, Immunologic; Female; Humans; Interleukin-2; Killer Cells, Natural; Leupeptins; Macaca mulatta; Male; Retroviridae Infections; Simian Immunodeficiency Virus | 1990 |
Multiple proteases regulate neurite outgrowth in NB2a/dl neuroblastoma cells.
Topics: Animals; Axons; Blood; Calpain; Endopeptidases; Hirudins; Leupeptins; Neuroblastoma; Osmolar Concentration; Protease Inhibitors; Thrombin; Tumor Cells, Cultured | 1991 |
Protein phosphorylation substrates in normal and neoplastic squamous epithelia of the human upper aero-digestive tract.
Topics: Aged; Autoradiography; Calcium; Carcinoma, Squamous Cell; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Humans; Leupeptins; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Proteins; Tissue Extracts | 1991 |
Myofibrillar proteinase, cathepsin B, and protein breakdown rates in skeletal muscle from septic rats.
Topics: Animals; Cathepsin B; Endopeptidases; Infections; Leupeptins; Male; Muscle Proteins; Muscles; Myofibrils; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome).
Topics: Amino Acid Sequence; Animals; Antipain; Cattle; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Erythrocytes; Humans; Insulin; Kinetics; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Oxidation-Reduction; Pentamidine; Proteasome Endopeptidase Complex | 1991 |
Effects of calcium on protein turnover of incubated muscles from mdx mice.
Topics: Animals; Calcium; Cycloheximide; Kinetics; Leupeptins; Methylamines; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscles; Muscular Dystrophy, Animal; Proteins; Tyrosine | 1991 |
Effect of calpain inhibitors on the invasion of human erythrocytes by the parasite Plasmodium falciparum.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Erythrocytes; Humans; Leucine; Leupeptins; Oligopeptides; Pepstatins; Plasmodium falciparum | 1991 |
Characterization of calcium-independent forms of protein kinase C-beta in phorbol ester-treated rabbit platelets.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Blood Platelets; Blotting, Western; Calcium; Cell Compartmentation; Enzyme Activation; In Vitro Techniques; Leupeptins; Molecular Sequence Data; Molecular Weight; Peptides; Phosphorylation; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1991 |
Leupeptin causes an accumulation of lipofuscin-like substances in liver cells of young rats.
Topics: Aging; Animals; Ceroid; Histocytochemistry; Leupeptins; Lipofuscin; Liver; Male; Microscopy, Fluorescence; Rats; Rats, Inbred F344 | 1991 |
Two-stage autolysis of the catalytic subunit initiates activation of calpain I.
Topics: Amino Acid Sequence; Animals; Calcium; Calcium-Binding Proteins; Calpain; Carbohydrate Sequence; Cattle; Enzyme Activation; Erythrocytes; Leupeptins; Molecular Sequence Data | 1991 |
Study of thiol proteases of normal human skin fibroblasts.
Topics: Caseins; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Cell Fractionation; Cells, Cultured; Concanavalin A; Coumarins; Cysteine Endopeptidases; Dipeptides; Endopeptidases; Fibroblasts; Humans; Hydrogen-Ion Concentration; Hymecromone; Leupeptins; Lysosomes; Microsomes; Skin | 1991 |
The effect of lysosomal inhibitors on protein degradation in cat hepatocyte monolayers.
Topics: Ammonium Chloride; Animals; Cats; Cells, Cultured; Cycloheximide; Insulin; Leucine; Leupeptins; Liver; Lysosomes; Proteins | 1991 |
Calpain inhibitors block long-term potentiation.
Topics: Animals; Calpain; Glycoproteins; Hippocampus; In Vitro Techniques; Kinetics; Leupeptins; Neuronal Plasticity; Rats; Rats, Inbred Strains; Synapses | 1990 |
Prevention of thromboxane B2-induced hepatocyte plasma membrane bleb formation by certain prostaglandins and a proteinase inhibitor.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Calcimycin; Calcium; Cell Membrane; Epoprostenol; Leupeptins; Liver; Male; Oligopeptides; Prostaglandins E, Synthetic; Rats; Thromboxane B2 | 1990 |
Endocytosis and degradation of ovine prolactin by Nb2 lymphoma cells: characterization and effects of agents known to alter prolactin-induced mitogenesis.
Topics: Amiloride; Animals; Calcimycin; Cell Division; Cell Membrane; Chloroquine; Endocytosis; Kinetics; Leupeptins; Lymphoma; Methylamines; Mitosis; Monensin; Prolactin; Rats; Receptors, Prolactin; Sheep; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Assembly and GPIIIa content of cytoskeletal core in platelets agglutinated with bovine von Willebrand factor.
Topics: Actinin; Actins; Adenosine Diphosphate; Adult; Animals; Blood Platelets; Calpain; Cattle; Cytoskeleton; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Leupeptins; Microfilament Proteins; Molecular Weight; Myosins; Platelet Aggregation; Platelet Membrane Glycoproteins; von Willebrand Factor | 1990 |
Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling.
Topics: Animals; Aorta; Biological Transport; Cattle; Cells, Cultured; Chloroquine; Chondroitin Sulfate Proteoglycans; Cytochalasin B; Endothelium, Vascular; Female; Glycosaminoglycans; Heparan Sulfate Proteoglycans; Heparin; Heparin Lyase; Heparitin Sulfate; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Lipoprotein Lipase; Milk; Monensin; Polysaccharide-Lyases; Protein Binding; Proteoglycans; Swine | 1990 |
Stabilization of rat cardiac sacroplasmic reticulum Ca2+ uptake activity and isolation of vesicles with improved calcium uptake activity.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Centrifugation, Density Gradient; Dithiothreitol; Dogs; Electrophoresis, Polyacrylamide Gel; Kinetics; Leupeptins; Male; Myocardium; Phenylmethylsulfonyl Fluoride; Potassium Chloride; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum; Sulfites | 1990 |
Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slices.
Topics: Animals; Calpain; Cell Hypoxia; Glycoproteins; Hippocampus; In Vitro Techniques; Leupeptins; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission | 1990 |
Endocytosis of liposomes containing lysosomal proteins increases intracellular protein degradation in growing L-132 cells.
Topics: Cathepsins; Cells, Cultured; Chloroquine; Drug Carriers; Endocytosis; Ferritins; Humans; L Cells; Leupeptins; Liposomes; Lysosomes; Membrane Proteins; Microinjections; Microscopy, Electron; Peptide Hydrolases; Protein Biosynthesis; Proteins; Time Factors | 1990 |
Regulation of total and myofibrillar protein breakdown in rat extensor digitorum longus and soleus muscle incubated flaccid or at resting length.
Topics: Animals; Insulin; Kinetics; Leupeptins; Male; Methylhistidines; Muscle Proteins; Muscles; Myofibrils; Rats; Rats, Inbred Strains; Tyrosine | 1990 |
Trypsin-like hatching protease from mouse embryos: evidence for the presence in culture medium and its enzymatic properties.
Topics: Animals; Blastocyst; Coumarins; Culture Media; Embryo, Mammalian; Leupeptins; Metalloendopeptidases; Mice; Mice, Inbred ICR; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Serine Endopeptidases; Substrate Specificity | 1990 |
Cooperation of lysosomes and inner mitochondrial membrane in the degradation of carbamoyl phosphate synthetase and other proteins.
Topics: Adenosine Triphosphate; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Enzyme Activation; Glutamates; Hydrogen-Ion Concentration; Intracellular Membranes; Leupeptins; Lysosomes; Mitochondria, Liver; Oligopeptides; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Rats; Substrate Specificity | 1990 |
Phalloidin-induced accumulation of myosin in rat hepatocytes is caused by suppression of autolysosome formation.
Topics: Acid Phosphatase; Actins; Animals; Cathepsins; Female; Fructose-Bisphosphate Aldolase; Immunoenzyme Techniques; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Microscopy, Electron; Myosins; Oligopeptides; Phalloidine; Pyruvate Kinase; Rats; Rats, Inbred Strains | 1990 |
Another mechanism for the defect in type III collagen accumulation in Ehlers-Danlos syndrome type IV: increased intracellular degradation of the procollagen.
Topics: Ammonium Chloride; Biological Transport; Blotting, Southern; Cells, Cultured; Collagen; Ehlers-Danlos Syndrome; Extracellular Space; Fluorescent Antibody Technique; Glycosylation; In Vitro Techniques; Leupeptins; Lysosomes; Peptide Fragments; Procollagen; Skin | 1990 |
Phylogeny of immune recognition: antigen processing/presentation in channel catfish immune responses to hemocyanins.
Topics: Ammonium Chloride; Animals; Antibody Formation; Antigen-Presenting Cells; Antigens; B-Lymphocytes; Chloroquine; Fixatives; Hemocyanins; Ictaluridae; In Vitro Techniques; Leupeptins; Lymphocyte Activation; Monensin; Monocytes; Phenylmethylsulfonyl Fluoride | 1990 |
Protein breakdown in submandibular glands rendered hypertrophic by amputation of lower incisor teeth in rats.
Topics: Aminocaproic Acid; Animals; Antipain; Hypertrophy; Incisor; Leupeptins; Male; Mandible; Pepstatins; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Rats; Rats, Inbred Strains; Salivary Proteins and Peptides; Submandibular Gland | 1990 |
Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts.
Topics: Animals; Cathepsin L; Cathepsins; Cell Line; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Fibroblasts; Kinetics; Leupeptins; Methionine; Mice; Molecular Weight | 1990 |
Factors influencing the binding of calpain I to human erythrocyte inside-out vesicles.
Topics: Arginase; Calcium; Calcium-Binding Proteins; Calpain; Caseins; Erythrocyte Membrane; Humans; Immunoelectrophoresis; Immunoglobulins; Leupeptins; Models, Biological; Muramidase; Ovalbumin; Protease Inhibitors | 1990 |
Proteolysis is a critical step in the physiological stop pathway: mechanisms involved in the blockade of axonal regeneration by mammalian astrocytes.
Topics: Animals; Astrocytes; Enzyme Inhibitors; Injections, Spinal; Leupeptins; Male; Microscopy, Electron; Nerve Endings; Nerve Regeneration; Nerve Tissue Proteins; Oligopeptides; Rats; Rats, Inbred Strains; Spinal Nerve Roots | 1990 |
Uptake and intracellular processing of galactosyl-neoglycoalbumin by the isolated perfused rat liver.
Topics: 1-Naphthylisothiocyanate; Albumins; Animals; Asialoglycoprotein Receptor; Bile; Biological Transport, Active; In Vitro Techniques; Leupeptins; Liver; Perfusion; Rats; Receptors, Immunologic | 1990 |
Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes.
Topics: Animals; Cell Fractionation; Centrifugation, Density Gradient; Cytosol; Electricity; Female; Half-Life; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Phagocytosis; Rats; Rats, Inbred Strains; Vacuoles | 1990 |
Stabilization of insulin receptor subunit structure by glutathione-insulin transhydrogenase.
Topics: Animals; Antipain; Aprotinin; Electrophoresis, Polyacrylamide Gel; Ethylmaleimide; Insulin; Isomerases; Leupeptins; Macromolecular Substances; Molecular Weight; Oxidoreductases; Protein Disulfide Reductase (Glutathione); Protein Disulfide-Isomerases; Rats; Receptor, Insulin | 1986 |
Degradation of [125I]iodoglucagon by normal rat plasma in radioimmunoassay mixture containing aprotinin and its prevention by p-chloromercuriphenyl sulfonate and leupeptin.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Aprotinin; Blood; Chromatography, Gel; Dose-Response Relationship, Drug; Glucagon; Immune Sera; Leupeptins; Male; Oligopeptides; Phenylmercury Compounds; Protease Inhibitors; Radioimmunoassay; Rats; Rats, Inbred Strains | 1986 |
Antigen-Ia interaction and the proteolytic processing of antigen: the structure of the antigen determines its restriction to the A or E molecule of the major histocompatibility complex.
Topics: Animals; Antigen-Presenting Cells; Antigens; Clone Cells; Epitopes; H-2 Antigens; Histocompatibility Antigens Class II; Leupeptins; Major Histocompatibility Complex; Mice; Mice, Inbred Strains; Muramidase; Peptide Hydrolases; T-Lymphocytes | 1986 |
Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.
Topics: Animals; Caenorhabditis elegans Proteins; Calcium; Carrier Proteins; Cell Line; Chromatography, Gel; Cytosol; Diglycerides; Female; Keratins; Leupeptins; Molecular Weight; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylserines; Pregnancy; Protein Kinase C; Rats; Receptors, Drug; Receptors, Immunologic; Skin; Tetradecanoylphorbol Acetate; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1986 |
Effect of protease inhibitors on skeletal muscle lysosomal enzyme activity and resting membrane potential.
Topics: Acetylglucosaminidase; Animals; Aprotinin; Chloroquine; Leupeptins; Lysosomes; Male; Membrane Potentials; Muscle Denervation; Muscles; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Rats; Rats, Inbred Strains | 1986 |
[Comparative studies of nafamostat mesilate and various serine protease inhibitors in vitro].
Topics: alpha-Macroglobulins; Aprotinin; Benzamidines; Complement Inactivator Proteins; Gabexate; Glycoproteins; Guanidines; Hemolysis; In Vitro Techniques; Leupeptins; Protease Inhibitors; Protein Binding | 1986 |
Enzymatic regulation of calcium current in dialyzed and intact molluscan neurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Calmodulin-Binding Proteins; Egtazic Acid; Helix, Snails; In Vitro Techniques; Ion Channels; Leupeptins; Neurons; Phosphoprotein Phosphatases; Protein Kinases | 1986 |
Perinatal leupeptin retards subsequent acquisition of a visual discrimination task in chicks.
Topics: Animals; Aprotinin; Chickens; Discrimination Learning; Glutamates; Glutamic Acid; Leupeptins; Oligopeptides; Visual Perception; Vocalization, Animal | 1987 |
A G protein directly regulates mammalian cardiac calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Heart; Ion Channels; Isoproterenol; Leupeptins; Membrane Potentials; Phosphorylation; Thionucleotides; Ventricular Function | 1987 |
Potentiation of the cytotoxicity of peplomycin against Ehrlich ascites carcinoma by bleomycin hydrolase inhibitors.
Topics: Animals; Bleomycin; Carcinoma, Ehrlich Tumor; Cell Survival; Cysteine Endopeptidases; Drug Synergism; Female; Glycoside Hydrolases; Leucine; Leupeptins; Mice; Oligopeptides; Peplomycin | 1987 |
Leupeptin-mediated alteration of renal phagolysosomes: similarity to hyaline droplet nephropathy of male rats exposed to unleaded gasoline.
Topics: Alpha-Globulins; Animals; Gasoline; Kidney; Kidney Diseases; Leupeptins; Male; Oligopeptides; Petroleum; Phagosomes; Proteins; Rats; Rats, Inbred F344 | 1988 |
Enhancement of transformed cell growth in agar by serine protease inhibitors.
Topics: Antigens, Polyomavirus Transforming; Aprotinin; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Humans; Leupeptins; Serine Proteinase Inhibitors; Trypsin Inhibitor, Kunitz Soybean | 1988 |
Calcium-dependent inactivation of the ATP-sensitive K+ channel of rat ventricular myocytes.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane; Electric Conductivity; Fluorides; Heart; Heart Ventricles; Ion Channels; Kinetics; Leupeptins; Potassium; Rats | 1988 |
Regulation of Hermissenda K+ channels by cytoplasmic and membrane-associated C-kinase.
Topics: Animals; Calcium; Cell Membrane; Central Nervous System; Cytoplasm; Electric Conductivity; Ion Channels; Leupeptins; Models, Biological; Mollusca; Nerve Tissue Proteins; Phorbol Esters; Phosphorylation; Photoreceptor Cells; Potassium; Protein Kinase C; Trypsin | 1988 |
Regulation of glycosphingolipid glycosyltransferase by low density lipoprotein receptors in cultured human proximal tubular cells.
Topics: alpha-Fetoproteins; beta-Galactosidase; Cell Count; Cells, Cultured; Humans; Hyperlipoproteinemia Type II; Kidney Tubules, Proximal; Leupeptins; Lipoproteins, LDL; Methylation; Receptors, LDL; Time Factors | 1988 |
Individual class II-restricted antigenic determinants of the same protein exhibit distinct kinetics of appearance and persistence on antigen-presenting cells.
Topics: Animals; Antigen-Presenting Cells; B-Lymphocytes; Cell Line; Epitopes; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral; Histocompatibility Antigens Class II; Kinetics; Leupeptins; Mice; Mice, Inbred BALB C; T-Lymphocytes; Viral Proteins | 1988 |
[Phorbol myristate acetate promotes entry of calcium in hypophysial cells GH3 B6 via potential dependent calcium channels].
Topics: Animals; Barium; Calcium; Cell Line; Electrophysiology; Ion Channels; Leupeptins; Pituitary Gland; Rats; Tetradecanoylphorbol Acetate | 1988 |
Inhibition of proteolysis blocks anterograde-retrograde conversion of axonally transported vesicles.
Topics: Animals; Axonal Transport; Axons; Leucine; Leupeptins; Male; Microscopy, Electron; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Reference Values; Sciatic Nerve | 1988 |
Identification of proteases that process distinct epitopes on the same protein.
Topics: Animals; Antigen-Presenting Cells; Antigens, Surface; Cathepsin B; Epitopes; Female; Histocompatibility Antigens Class II; Hydrolysis; Leupeptins; Male; Mice; Myoglobin; Peptide Hydrolases; Protease Inhibitors | 1989 |
Characterization of the catalytic residues of the tobacco etch virus 49-kDa proteinase.
Topics: Aprotinin; Binding Sites; DNA Mutational Analysis; Genes, Viral; Leupeptins; Papain; Peptide Hydrolases; Plant Viruses; Substrate Specificity; Viral Proteins; Zinc | 1989 |
Characterization of proteolytic and collagenolytic enzymes from the larvae of Lucilia cuprina, the sheep blowfly.
Topics: Animals; Aprotinin; Collagen; Diptera; Gelatin; Hydrogen-Ion Concentration; Isoelectric Point; Larva; Leupeptins; Microbial Collagenase; Molecular Weight; Peptide Hydrolases; Phenylmethylsulfonyl Fluoride; Protease Inhibitors | 1988 |
Purification and characterization of a protease from Xenopus embryos.
Topics: Animals; Antipain; Chromatography; Embryo, Nonmammalian; Enzyme Activation; Iodoacetates; Iodoacetic Acid; Leupeptins; Molecular Weight; Peptide Hydrolases; Polyribonucleotides; RNA; Substrate Specificity; Xenopus | 1989 |
Effects of lovastatin and leupeptin on ceroidogenesis of vitamin E-deficient and -supplemented young rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Ceroid; Cholesterol; Dolichols; Eating; Female; Kidney; Leupeptins; Liver; Lovastatin; Organ Size; Rats; Rats, Inbred Strains; Vitamin E; Vitamin E Deficiency | 1989 |
Lipofuscin-like substances accumulate rapidly in brain, retina and internal organs with cysteine protease inhibition.
Topics: Aging; Animals; Brain; Cysteine Proteinase Inhibitors; Dogs; Leupeptins; Lipofuscin; Lysosomes; Mice; Mice, Inbred C57BL; Microscopy, Electron; Rats; Rats, Inbred F344; Rats, Inbred Strains; Retina; Viscera | 1989 |
Morphological, physiological and biochemical alterations in livers of rodents induced by protease inhibitors: a comparison with old livers.
Topics: Aging; Animals; Biological Transport; Dolichols; Leucine; Leupeptins; Liver; Male; Mice; Mice, Inbred C57BL; Ouabain; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Inbred Strains; Sulfobromophthalein | 1989 |
An epidermal growth factor-ricin A chain (EGF-RTA)-resistant mutant and an epidermal growth factor-Pseudomonas endotoxin (EGF-PE)-resistant mutant have distinct phenotypes.
Topics: Adenoviridae; ADP Ribose Transferases; Ammonium Chloride; Bacterial Toxins; Drug Resistance; Epidermal Growth Factor; Exotoxins; HeLa Cells; Humans; Immunotoxins; Leupeptins; Mutation; Phenotype; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Ricin; Virulence Factors | 1989 |
Oleate-induced translocation of protein kinase C to hepatic microsomal membranes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Brain; Calcium; Fatty Acids; Intracellular Membranes; Isoenzymes; Isoquinolines; Leupeptins; Microsomes, Liver; Oleic Acid; Oleic Acids; Phorbol 12,13-Dibutyrate; Phosphatidate Phosphatase; Piperazines; Protein Kinase C; Rats; Spermine | 1989 |
Quantitation of platelet fibrinogen and thrombospondin in Glanzmann's thrombasthenia by electroimmunoassay.
Topics: Blood Platelet Disorders; Blood Platelets; Detergents; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Humans; Immunoblotting; Immunoelectrophoresis; Leupeptins; Membrane Glycoproteins; Octoxynol; Polyethylene Glycols; Thrombasthenia; Thrombospondins | 1989 |
Action of endogenous proteases on the distribution of tyrosinase isozymes in Harding-Passey mouse melanoma.
Topics: Animals; Catechol Oxidase; Cathepsin D; Cytosol; Hydrolysis; Isoenzymes; Leupeptins; Melanocytes; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Pepstatins; Peptide Hydrolases; Phenylmethylsulfonyl Fluoride; Solubility | 1989 |
Neuronal plasminogen activators: cell surface binding sites and involvement in neurite outgrowth.
Topics: Amino Acid Chloromethyl Ketones; Animals; Axons; Benzoates; Binding Sites; Cell Membrane; Cell Survival; Dansyl Compounds; Leupeptins; Neurons; Plasminogen Activators; Sympathetic Nervous System; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 1989 |
Intracellular degradation of unassembled asialoglycoprotein receptor subunits: a pre-Golgi, nonlysosomal endoproteolytic cleavage.
Topics: Acetylglucosaminidase; Animals; Asialoglycoprotein Receptor; Cell Line; Chloroquine; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fluorescent Antibody Technique; Golgi Apparatus; Half-Life; Leupeptins; Lysosomes; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Microscopy, Fluorescence; Molecular Weight; Monensin; Receptors, Immunologic; Temperature | 1989 |
Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes.
Topics: Animals; Ankyrins; Binding Sites; Blood Proteins; Brain; Cell Compartmentation; Cell Membrane; Erythrocytes; Fluorescent Antibody Technique; In Vitro Techniques; Kidney; Leupeptins; Membrane Proteins; Microsomes; Molecular Weight; Peptide Hydrolases; Protein Binding; Sheep; Spectrin | 1989 |
Ca2+-mediated activation of human erythrocyte membrane Ca2+-ATPase.
Topics: Calcium; Calcium-Transporting ATPases; Calmodulin; Calpain; Erythrocyte Membrane; Glycodeoxycholic Acid; Humans; Kinetics; Leupeptins | 1989 |
The thiol proteinase inhibitors improve the abnormal rapid down-regulation of protein kinase C and the impaired natural killer cell activity in (Chediak-Higashi syndrome) beige mouse.
Topics: Animals; Calpain; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Disease Models, Animal; Killer Cells, Natural; Killer Factors, Yeast; Leucine; Leupeptins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Protein Biosynthesis; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate | 1989 |
Thrombin-induced platelet aggregation involves an indirect proteolytic cleavage of aggregin by calpain.
Topics: Adenosine; Adenosine Diphosphate; Affinity Labels; Antipain; Blood Platelets; Calpain; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Humans; Leupeptins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protease Inhibitors; Thrombin | 1989 |
Degradation of 125I-glucagon, -pancreatic polypeptide and -insulin by acid saline extract of rat submaxillary gland and their protection by proteinase inhibitors.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Chemical Precipitation; Chromatography, Gel; Ethylmaleimide; Glucagon; Hydrogen-Ion Concentration; Insulin; Iodine Radioisotopes; Leupeptins; Pancreatic Polypeptide; Protease Inhibitors; Rats; Rats, Inbred Strains; Sodium Chloride; Submandibular Gland; Trichloroacetic Acid | 1989 |
Possibility of Bacteroides gingivalis hemagglutinin possessing protease activity revealed by inhibition studies.
Topics: Bacteroides; Benzoylarginine Nitroanilide; Hemagglutination Inhibition Tests; Hemagglutinins; Leupeptins; Peptide Hydrolases; Protease Inhibitors | 1989 |
Murine erythroleukemia cells possess an active ubiquitin- and ATP-dependent proteolytic pathway.
Topics: Adenosine Triphosphate; Animals; Cell Differentiation; Lactoglobulins; Leukemia, Erythroblastic, Acute; Leupeptins; Ligases; Lysosomes; Mice; Peptide Hydrolases; Protease Inhibitors; Reticulocytes; Tumor Cells, Cultured; Ubiquitin-Protein Ligases; Ubiquitins | 1989 |
A growth hormone-vesicular stomatitis virus G hybrid protein is rapidly degraded in lysosomes following transport to the cell surface.
Topics: Animals; Cells, Cultured; Chloroquine; Cricetinae; Endocytosis; Growth Hormone; Kidney; Leupeptins; Lysosomes; Membrane Proteins; Monensin; Vesicular stomatitis Indiana virus; Viral Proteins | 1989 |
Evidence for two mechanisms of thrombin-induced platelet activation: one proteolytic, one receptor mediated.
Topics: Adenosine Diphosphate; Humans; In Vitro Techniques; Leupeptins; Phosphatidylinositols; Platelet Activating Factor; Platelet Activation; Receptors, Cell Surface; Receptors, Thrombin; Serotonin; Thrombin; Thromboxane A2; Trypsin | 1989 |
Metalloproteinases are not involved in the phagocytosis of collagen fibrils by fibroblasts.
Topics: Animals; Bone and Bones; Collagen; Culture Techniques; Cytochalasin B; Enzyme Inhibitors; Fibroblasts; Immune Sera; Immunoglobulin G; Kinetics; Leupeptins; Matrix Metalloproteinase 3; Metalloendopeptidases; Microbial Collagenase; Microscopy, Electron; Phagocytosis; Rabbits; Tissue Inhibitor of Metalloproteinases | 1989 |
Properties of erythrocyte membrane binding and autolytic activation of calcium-activated neutral protease.
Topics: Animals; Blood Proteins; Calcium; Calcium-Binding Proteins; Calpain; Caseins; Chickens; Egtazic Acid; Enzyme Activation; Erythrocyte Membrane; Immunoblotting; Kinetics; Leupeptins; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Rabbits; Vimentin | 1989 |
Differential effects of leupeptin, monensin and colchicine on ligand degradation mediated by the two asialoglycoprotein receptor pathways in isolated rat hepatocytes.
Topics: Animals; Asialoglycoproteins; Cells, Cultured; Chloroquine; Colchicine; Dose-Response Relationship, Drug; Galactose; Leupeptins; Liver; Male; Monensin; Oligopeptides; Orosomucoid; Rats; Rats, Inbred Strains; Receptors, Cell Surface | 1989 |
Cobalamin release from intrinsic factor and transfer to transcobalamin II within the rat enterocyte.
Topics: Administration, Oral; Animals; Animals, Suckling; Chloroquine; Gastric Mucosa; Immune Sera; Intestinal Mucosa; Intestines; Intrinsic Factor; Leupeptins; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Transcobalamins; Vitamin B 12 | 1989 |
Formation of N epsilon-(gamma-glutamyl)-lysine isodipeptide in Chinese-hamster ovary cells.
Topics: Animals; Cell Division; Cell Line; Chromatography, Ion Exchange; Cricetinae; Cricetulus; Dipeptides; gamma-Glutamylcyclotransferase; In Vitro Techniques; Leupeptins; Methylamines; Oligopeptides; Proteins; Transglutaminases | 1989 |
Elucidation of cathepsin B-like activity associated with extracts of human myelin basic protein.
Topics: 4-Chloromercuribenzenesulfonate; Cathepsin B; Cathepsins; Dithioerythritol; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Leucine; Leupeptins; Myelin Basic Protein; Protease Inhibitors | 1985 |
Effect of proteases on the beta-thromboglobulin radioimmunoassay.
Topics: Animals; Aprotinin; Beta-Globulins; beta-Thromboglobulin; Histamine Release; Leupeptins; Mast Cells; p-Methoxy-N-methylphenethylamine; Pancreatic Elastase; Peptide Hydrolases; Platelet Factor 4; Radioimmunoassay; Rats; Rats, Inbred Strains | 1985 |
Various proteinase inhibitors decrease prolactin and growth hormone release by anterior pituitary cells.
Topics: Animals; Aprotinin; Cells, Cultured; Dose-Response Relationship, Drug; Female; Growth Hormone; Leupeptins; Oligopeptides; Phenylmethylsulfonyl Fluoride; Pituitary Gland, Anterior; Prolactin; Protease Inhibitors; Rats; Trypsin Inhibitor, Kunitz Soybean | 1985 |
Regulation of ppp(A2'p)nA-dependent RNase levels during interferon treatment and cell differentiation.
Topics: Affinity Labels; Animals; Cell Differentiation; Cell Line; Endoribonucleases; Interferons; Leupeptins; Mice; Neoplasms, Germ Cell and Embryonal; Protein Kinases; Ribonucleases | 1985 |
Leupeptin as a tool for the detection of the sites of catabolism of rat high-density lipoprotein apolipoproteins A-I and E.
Topics: alpha-Fetoproteins; Animals; Apolipoprotein A-I; Apolipoproteins A; Apolipoproteins E; Asialoglycoproteins; Cathepsins; Fetuins; Kidney; Leupeptins; Lipoproteins, HDL; Liver; Lysosomes; Male; Oligopeptides; Rats; Rats, Inbred Strains; Serum Albumin; Time Factors | 1985 |
Effects of lysosomal inhibitors on 125I-insulin and 125I-asialofetuin degradation by the isolated, perfused rat liver and isolated rat hepatocytes.
Topics: alpha-Fetoproteins; Ammonium Chloride; Animals; Asialoglycoproteins; Chloroquine; Fetuins; In Vitro Techniques; Insulin; Iodine Radioisotopes; Leupeptins; Liver; Lysosomes; Male; Perfusion; Rats; Rats, Inbred Strains | 1985 |
The protease inhibitor leupeptin interferes with the development of LTP in hippocampal slices.
Topics: Action Potentials; Animals; Hippocampus; In Vitro Techniques; Leupeptins; Male; Neuronal Plasticity; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains | 1989 |
Secretory activity as a function of the development and maturation of ameloblasts.
Topics: Ameloblasts; Animals; Cell Differentiation; Dental Enamel; Dental Enamel Proteins; In Vitro Techniques; Leupeptins; Lysosomes; Male; Rats; Rats, Inbred Strains | 1989 |
Structural and functional aspects of HLA class II glycoproteins and the associated invariant chain.
Topics: Cell Line; Glycoproteins; HLA-D Antigens; Humans; Leupeptins; Molecular Structure; Molecular Weight; Monensin; Peptides; Protein Binding; Protein Conformation | 1989 |
The influence of cathepsin B and leupeptin on potentially lethal damage repair in mammalian cells.
Topics: Animals; Aspartic Acid Endopeptidases; Cathepsin B; Cell Line; Cell Survival; Cysteine Endopeptidases; DNA; DNA Repair; Endopeptidases; Leupeptins; Mutation; Oligopeptides; Serine Endopeptidases | 1989 |
Activation of an insulin-stimulated S6 kinase in 3T3 L1 cell-free extracts by proteolysis.
Topics: Animals; Calcium; Cell-Free System; Chromatography; Enzyme Activation; Insulin; L Cells; Leupeptins; Mice; Peptide Hydrolases; Phosphates; Phosphorylation; Protein Kinases; Ribosomal Protein S6 Kinases; Trypsin | 1989 |
Leupeptin alters the proteolytic processing of P126, the major parasitophorous vacuole antigen of Plasmodium falciparum.
Topics: Animals; Antigens, Protozoan; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Humans; Hydrolysis; Immunosorbent Techniques; Leupeptins; Oligopeptides; Peptide Fragments; Plasmodium falciparum; Protease Inhibitors; Trypsin | 1989 |
Differences in induction of lysosomal protease activity by protease inhibitors in B16 melanoma cell lines.
Topics: Acid Phosphatase; Animals; Cathepsin B; Enzyme Induction; Leucine; Leupeptins; Melanoma, Experimental; Mice; Oligopeptides; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Subcellular Fractions; Tumor Cells, Cultured | 1989 |
Effects of inhibitors of membrane signal peptide peptidase on protein translocation into membrane vesicles.
Topics: Alkaline Phosphatase; Antipain; Bacterial Outer Membrane Proteins; Endopeptidases; Escherichia coli; Leupeptins; Membrane Proteins; Oligopeptides; Protease Inhibitors; Protein Processing, Post-Translational; Protein Sorting Signals; Serine Endopeptidases | 1989 |
Impaired cholesterol esterification in cultured skin fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy.
Topics: Autoradiography; Cell Fractionation; Cells, Cultured; Cholesterol Esters; Esterification; Fibroblasts; Humans; Leupeptins; Lysosomes; Monensin; Mucolipidoses; Niemann-Pick Diseases | 1989 |
Degeneration of neuronal processes in rats induced by a protease inhibitor, leupeptin.
Topics: Animals; Central Nervous System; Enzyme Inhibitors; Injections, Intraventricular; Leupeptins; Microscopy, Electron; Nerve Degeneration; Neurotoxins; Oligopeptides; Rats; Rats, Inbred Strains | 1989 |
Cytotoxicities of two disulfide-bond-linked conjugates of methotrexate with monoclonal anti-MM46 antibody.
Topics: Animals; Antibodies, Monoclonal; Carcinoma, Ehrlich Tumor; Complement System Proteins; Cytotoxicity, Immunologic; Disulfides; Folic Acid Antagonists; Immunotoxins; Leupeptins; Methotrexate; Mice; Mice, Inbred C3H; Sulfhydryl Compounds; Thiamine Pyrophosphate | 1989 |
Microinjections of leupeptin in the frontal cortex or dorsal hippocampus block spatial learning in the rat.
Topics: Animals; Arousal; Brain Mapping; Discrimination Learning; Frontal Lobe; Hippocampus; Injections; Leupeptins; Male; Memory; Mental Recall; Motor Activity; Oligopeptides; Orientation; Rats; Rats, Inbred Strains | 1989 |
Epidermal growth factor-induced truncation of the epidermal growth factor receptor.
Topics: Animals; Cells, Cultured; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Leupeptins; Methylamines; Mice; Mice, Inbred Strains; Molecular Weight; Thermodynamics | 1989 |
The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytochalasin B; Diacylglycerol Kinase; Isoquinolines; Kinetics; Leupeptins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phosphotransferases; Piperazines; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rabbits; Superoxides; Thiazoles | 1987 |
Aggregation-related association of lipid with the cytoskeleton of rabbit and human platelets prelabeled with [3H]palmitic acid. Similar effects of adenosine diphosphate- and thrombin-induced aggregation.
Topics: Actin Cytoskeleton; Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Cyclic AMP; Cytoskeleton; Deoxyribonuclease I; Fibrinogen; Humans; In Vitro Techniques; Leupeptins; Lipid Metabolism; Microscopy, Electron; Palmitic Acid; Palmitic Acids; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Thrombin | 1988 |
Stimulation of high-affinity GTPase by trypsin and trypsin-like proteinases in membranes of human platelets.
Topics: Blood Platelets; Cell Membrane; Chymotrypsin; Endopeptidases; Epinephrine; Ethylmaleimide; GTP Phosphohydrolases; Guanosine Triphosphate; Humans; In Vitro Techniques; Leupeptins; Phosphoric Monoester Hydrolases; Stimulation, Chemical; Thrombin; Trypsin | 1988 |
Inhibition of thrombin-induced platelet activation by leupeptin. Implications for the participation of calpain in the initiation of platelet activation.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Antipain; Calpain; Dose-Response Relationship, Drug; GTP-Binding Proteins; Humans; Leupeptins; Oligopeptides; Phosphatidic Acids; Phosphatidylinositols; Platelet Aggregation; Thrombin; Virulence Factors, Bordetella | 1988 |
Cytocidal mechanism of TNF: effects of lysosomal enzyme and hydroxyl radical inhibitors on cytotoxicity.
Topics: Ammonium Chloride; Animals; Chloroquine; Cytotoxicity, Immunologic; Dimethyl Sulfoxide; Free Radicals; Hydroxides; Hydroxyl Radical; Leupeptins; Masoprocol; Methylamines; Mice; Muramidase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1988 |
Fluoride-dependent calcium-induced platelet procoagulant activity shows that calpain is involved in increased phospholipid transbilayer movement.
Topics: Blood Platelets; Calcium; Calpain; Fluorides; Humans; In Vitro Techniques; Leupeptins; Lipid Bilayers; Membrane Lipids; Membrane Proteins; Motion; Phosphatidylserines; Thromboplastin | 1988 |
Evidence for two independent pathways of insulin-receptor internalization in hepatocytes and hepatoma cells.
Topics: 2,4-Dinitrophenol; Animals; Biological Transport; Biotransformation; Carcinoma, Hepatocellular; Cells, Cultured; Chloroquine; Coated Pits, Cell-Membrane; Dinitrophenols; Humans; Insulin; Leupeptins; Liver; Liver Neoplasms; Monensin; Osmolar Concentration; Potassium; Rats; Receptor, Insulin; Tumor Cells, Cultured | 1988 |
Synthesis of a new cell penetrating calpain inhibitor (calpeptin).
Topics: Animals; Blood Platelets; Calcimycin; Calpain; Cell Membrane Permeability; Dipeptides; Leupeptins; Microfilament Proteins; Papain; Peptides; Swine | 1988 |
Calcium-activated neutral proteases (calpains) are carbohydrate binding proteins.
Topics: Calcium; Calcium-Binding Proteins; Calpain; Carbohydrate Metabolism; Chromatography; Disaccharides; Enzyme Activation; Ethylene Glycol; Ethylene Glycols; Leupeptins; Octoxynol; Polyethylene Glycols; Sepharose; Thiocyanates; Urea | 1988 |
The effect of microinfusions of drugs into the accessory olfactory bulb on the olfactory block to pregnancy.
Topics: Animals; Anisomycin; Bicuculline; Dose-Response Relationship, Drug; Female; Leupeptins; Male; Mice; Mice, Inbred BALB C; Microinjections; Olfactory Bulb; Phentolamine; Pheromones; Pregnancy; Pregnancy, Animal; Receptors, Adrenergic, alpha | 1988 |
Lesions of entorhinal cortex produce a calpain-mediated degradation of brain spectrin in dentate gyrus. I. Biochemical studies.
Topics: Animals; Calmodulin; Calpain; Cerebral Cortex; Enzyme Inhibitors; Hippocampus; Injections, Intraventricular; Leupeptins; Male; Molecular Weight; Rats; Rats, Inbred Strains; Spectrin | 1988 |
Lesions of entorhinal cortex produce a calpain-mediated degradation of brain spectrin in dentate gyrus. II. Anatomical studies.
Topics: Animals; Calpain; Cerebral Cortex; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Leupeptins; Male; Nerve Degeneration; Rats; Rats, Inbred Strains; Spectrin; Time Factors | 1988 |
Protease inhibitors suppress the in vitro and in vivo replication of rotavirus.
Topics: Animals; Benzimidazoles; Cell Line; Humans; Leupeptins; Mice; Pentamidine; Protease Inhibitors; Rotavirus; Virus Replication | 1988 |
Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain.
Topics: Animals; Blotting, Western; Calcimycin; Calcium; Calpain; Cell Membrane Permeability; Cytoskeletal Proteins; Dipeptides; Erythrocyte Membrane; Hydrolysis; Leupeptins; Membrane Proteins; Molecular Weight; Peptide Hydrolases; Protease Inhibitors; Rats; Spectrin | 1988 |
Ca2+-mediated catabolism of human erythrocyte band 3 protein.
Topics: Anion Exchange Protein 1, Erythrocyte; Calcium; Calpain; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Leupeptins; Molecular Weight | 1988 |
The effects of cytotropic compounds on the resialylation of human asialotransferrin type 3 in the rat.
Topics: Alkaloids; Animals; Asialoglycoproteins; Chloroquine; Colchicine; Female; Humans; Leupeptins; Liver; Lysine; Male; Microtubules; Paclitaxel; Protein Biosynthesis; Rats; Starvation; Transferrin; Vinblastine | 1985 |
Insulin processing and action in adipocytes: evidence for generation of insulin-containing vesicles by leupeptin and monensin.
Topics: Acetyl-CoA Carboxylase; Adipose Tissue; Animals; Centrifugation, Density Gradient; Deoxyglucose; Enzyme Activation; Female; Furans; Insulin; Leupeptins; Microscopy, Electron; Monensin; Oligopeptides; Organoids; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains | 1985 |
Inhibition of plant cell proteolytic activities that degrade tubulin.
Topics: Alkaloids; Electrophoresis, Polyacrylamide Gel; Immunosorbent Techniques; Leupeptins; Molecular Weight; Paclitaxel; Pepstatins; Plants; Protease Inhibitors; Tubulin | 1985 |
Receptor-bound somatostatin and epidermal growth factor are processed differently in GH4C1 rat pituitary cells.
Topics: Ammonium Chloride; Animals; Cell Compartmentation; Cell Line; Cell Membrane; Chloroquine; Cytosol; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Leupeptins; Lysosomes; Pituitary Neoplasms; Protein Binding; Rats; Receptors, Cell Surface; Receptors, Somatostatin; Somatostatin | 1986 |
Targeting, internalization, and cytotoxicity of methotrexate-monoclonal anti-stage-specific embryonic antigen-1 antibody conjugates in cultured F-9 teratocarcinoma cells.
Topics: Animals; Antibodies, Monoclonal; Glycolipids; Immunoglobulin G; Leucovorin; Leupeptins; Lewis X Antigen; Lysosomes; Methotrexate; Mice; Mice, Inbred BALB C; Teratoma; Thiamine Pyrophosphate; Tritium | 1986 |
Biosynthesis of intestinal microvillar proteins. Processing of N-linked carbohydrate is not required for surface expression.
Topics: Alkaloids; Aminopeptidases; Animals; Carbohydrate Metabolism; CD13 Antigens; Electrophoresis, Polyacrylamide Gel; Indolizines; Intestinal Mucosa; Leupeptins; Membrane Proteins; Microvilli; Organ Culture Techniques; Swine | 1986 |
Platelet factor XIII is activated by calpain.
Topics: Blood Platelets; Calcium; Calcium-Binding Proteins; Calpain; Enzyme Activation; Factor XIII; Humans; In Vitro Techniques; Leupeptins; Thrombin; Transglutaminases | 1987 |
Spatial learning in the rat: impairment induced by the thiol-proteinase inhibitor, leupeptin, and an analysis of [3H]glutamate receptor binding in relation to learning.
Topics: Animals; Brain; Discrimination Learning; Glutamates; Glutamic Acid; Hippocampus; Injections, Intraventricular; Leupeptins; Male; Memory; Mental Recall; Neural Pathways; Oligopeptides; Orientation; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Space Perception; Synaptic Membranes | 1987 |
The effect of analogues of chymostatin on lysosomal and non-lysosomal components of protein degradation in isolated hepatocytes.
Topics: Adenosine Triphosphate; Animals; Gluconeogenesis; In Vitro Techniques; Leupeptins; Liver; Lysosomes; Male; Oligopeptides; Protease Inhibitors; Rats; Structure-Activity Relationship; Tyrosine Transaminase | 1987 |
Active and inactive forms of the transition-state analog protease inhibitor leupeptin: explanation of the observed slow binding of leupeptin to cathepsin B and papain.
Topics: Algorithms; Arginine; Cathepsin B; Chromatography, High Pressure Liquid; Kinetics; Leupeptins; Magnetic Resonance Spectroscopy; Oligopeptides; Papain; Protease Inhibitors | 1989 |
Comparative studies on insulin-like growth factor II and insulin processing by vascular endothelial cells.
Topics: Animals; Aorta; Biological Transport; Cattle; Cells, Cultured; Chloroquine; Endothelium; Insulin; Insulin-Like Growth Factor II; Kinetics; Leupeptins; Models, Biological; Monensin; Receptor, Insulin; Receptors, Somatomedin; Somatomedins | 1986 |
Evidence for two catabolic endoglycosidase activities in beta-mannosidase-deficient goat fibroblasts.
Topics: Animals; beta-Mannosidase; Biological Transport; Carbohydrate Sequence; Carrier Proteins; Cells, Cultured; Fibroblasts; Glycoproteins; Glycoside Hydrolases; Goats; Leupeptins; Lysosomes; Mannosidases; Receptor, IGF Type 2; Structure-Activity Relationship | 1987 |
Antipain or leupeptin in combination with aspirin or indomethacin synergistically inhibit human platelet activation by thrombin and trypsin.
Topics: Antipain; Aspirin; Blood Platelets; Drug Synergism; Humans; In Vitro Techniques; Indomethacin; Leupeptins; Oligopeptides; Thrombin; Trypsin | 1987 |
Membrane glycoproteins are involved in the differentiation of the BC3H1 muscle cell line.
Topics: 1-Deoxynojirimycin; Acetylglucosamine; Alkaloids; Animals; Cell Differentiation; Cell Line; Creatine Kinase; Deoxy Sugars; Deoxyglucose; Enzyme Induction; Glucosamine; Glycoproteins; Indolizines; Leupeptins; Membrane Glycoproteins; Membrane Proteins; Mice; Muscles; Oligosaccharides; Swainsonine; Tunicamycin | 1987 |
Analysis of proteolytic processing during specific antigen presentation.
Topics: Animals; Antigen-Presenting Cells; Antigens; B-Lymphocytes; Cells, Cultured; Chloroquine; Haptens; Leupeptins; Lymphocyte Cooperation; Mice; Peptide Hydrolases; Receptors, Antigen, T-Cell; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Tosylphenylalanyl Chloromethyl Ketone; Trinitrobenzenes | 1987 |
Intracellular processing of epidermal growth factor and its effect on ligand-receptor interactions.
Topics: Animals; Cathepsin B; Cathepsins; Cell Line; Cold Temperature; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Hydrogen-Ion Concentration; Leupeptins; Methylamines; Mice; Models, Biological; Monensin; Receptors, Cell Surface | 1985 |
Leupeptin, a protease inhibitor, blocks insemination-induced flight muscle histolysis in the fire ant Solenopsis.
Topics: Animals; Ants; Atrophy; Calpain; Cytoskeleton; Endopeptidases; Female; Insemination; Leupeptins; Muscle Proteins; Muscles; Oligopeptides; Protease Inhibitors; Wings, Animal | 1985 |
A human platelet angiotensin I-processing system. Identification of components and inhibition of angiotensin-converting enzyme by product.
Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Blood Platelets; Chromatography, Gel; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Iodoacetamide; Leupeptins; Lung; Mersalyl; Molecular Weight; Rabbits | 1985 |
Inhibition of fibrinogen receptor expression and serotonin release by leupeptin and antipain.
Topics: Antipain; Binding, Competitive; Blood Platelets; Fibrinogen; Humans; Kinetics; Leupeptins; Oligopeptides; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Serotonin; Thrombin | 1985 |
Activation of the PCSM-protein phosphatase by a Ca2+-dependent protease.
Topics: Animals; Calpain; Egtazic Acid; Enzyme Activation; Kinetics; Leupeptins; Muscles; Phosphoprotein Phosphatases; Rabbits | 1985 |
Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.
Topics: Animals; Cell Compartmentation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Immunoenzyme Techniques; Leupeptins; Liver; Lysosomes; Molecular Weight; Phosphorylation; Protein Kinases; Rats; Receptors, Cell Surface; Temperature | 1986 |
Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor.
Topics: Antibodies, Monoclonal; Binding Sites, Antibody; Cell Line; Chloroquine; Endocytosis; Half-Life; Humans; Iron; Leukemia, Erythroblastic, Acute; Leupeptins; Receptors, Cell Surface; Receptors, Transferrin | 1986 |
Phosphorylation of bovine cardiac calcium-activated neutral protease by protein kinase-C.
Topics: Animals; Calpain; Cattle; Enzyme Activation; Leupeptins; Macromolecular Substances; Molecular Weight; Myocardium; Phosphorylation; Phosphothreonine; Protein Kinase C | 1986 |
Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring proteinase.
Topics: Calpain; Cytochalasin B; Endopeptidases; Exocytosis; Humans; Hydrogen Peroxide; Leupeptins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Retinaldehyde; Serine Endopeptidases; Tetradecanoylphorbol Acetate; Trifluoperazine | 1986 |
Cleavage site of calcium-dependent protease in human platelet membrane glycoprotein Ib.
Topics: Animals; Calcimycin; Calcium; Calpain; Chickens; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Humans; Isoelectric Point; Leucine; Leupeptins; Membrane Proteins; Molecular Weight; Phenotype; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins | 1986 |
Limited proteolysis of the erythrocyte membrane skeleton by calcium-dependent proteinases.
Topics: Anion Exchange Protein 1, Erythrocyte; Blood Proteins; Calcimycin; Calpain; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Humans; Leupeptins; Membrane Proteins; Mersalyl; Neuropeptides; Spectrin | 1986 |
Effect of low calcium and protease inhibitors on synapse elimination during postnatal development in the rat soleus muscle.
Topics: Animals; Animals, Newborn; Calcium; Calpain; Egtazic Acid; Leupeptins; Mersalyl; Muscle Development; Neuromuscular Junction; Rats; Rats, Inbred Strains | 1986 |
Four Ca2+-dependent proteinase activities isolated from crustacean muscle differ in size, net charge, and sensitivity to Ca2+ and inhibitors.
Topics: Animals; Calcium; Calcium Channel Blockers; Calpain; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Iodoacetamide; Leupeptins; Molecular Weight; Muscles; Nephropidae; Pepstatins; Phenylmethylsulfonyl Fluoride | 1986 |
Calcium-induced degeneration of the cytoskeleton in monkey and human peripheral nerves.
Topics: Animals; Calcium; Calpain; Cebus; Culture Media; Cytoskeleton; Humans; Intermediate Filaments; Leupeptins; Microtubules; Nerve Degeneration; Peripheral Nerves; Wallerian Degeneration | 1986 |
Targeting of neoglycoprotein-drug conjugates to cultured human embryonal carcinoma cells.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Cisplatin; Etoposide; Glycoproteins; Humans; Lectins; Leupeptins; Methotrexate; Pharmaceutical Vehicles; Receptors, Cell Surface; Teratoma | 1987 |
Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases.
Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Brain; Carcinoma, Hepatocellular; Cattle; Cell Line; Endopeptidases; Fibroblast Growth Factors; Humans; Leupeptins; Liver Neoplasms; Molecular Weight; Protease Inhibitors | 1987 |
Sendai-viral HN and F glycoproteins as probes of plasma-membrane protein catabolism in HTC cells. Studies with fusogenic reconstituted Sendai-viral envelopes.
Topics: Ammonium Chloride; Animals; Azides; Cell Line; Deoxyglucose; DNA, Viral; Hemagglutinins, Viral; HN Protein; Leupeptins; Liver Neoplasms, Experimental; Membrane Fusion; Membrane Proteins; Parainfluenza Virus 1, Human; Sodium Azide; Viral Envelope Proteins; Viral Fusion Proteins | 1987 |
Protein damage and degradation by oxygen radicals. I. general aspects.
Topics: Adenosine Triphosphate; Free Radicals; Hydroxides; Hydroxyl Radical; Leupeptins; Proteins; Superoxides | 1987 |
Effects of low calcium and inhibition of calcium-activated neutral protease (CANP) on mature nerve terminal structure in the rat sternocostalis muscle.
Topics: Animals; Calcium; Calpain; Egtazic Acid; Leupeptins; Motor Neurons; Neuromuscular Junction; Neuronal Plasticity; Rats; Rats, Inbred Strains | 1987 |
Regulation of the breakdown rates of biotin-containing proteins in Swiss 3T3-L1 cells.
Topics: Adenine; Biotin; Cell Line; Electrophoresis, Polyacrylamide Gel; Insulin; Leucine; Leupeptins; Proteins | 1988 |
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
Topics: Animals; Cysteine Endopeptidases; Hemoglobins; Leucine; Leupeptins; Malaria; Microscopy, Electron; Molecular Weight; Plasmodium falciparum; Protease Inhibitors | 1988 |
Evidence for the role of proteinases in uremic catabolism.
Topics: Acute Disease; Animals; Blood Chemical Analysis; Endopeptidases; Hydrolysis; Leupeptins; Male; Methylhistidines; Muscle Proteins; Nephrectomy; Protease Inhibitors; Rats; Rats, Inbred Strains; Uremia | 1988 |
Ultrastructural study of the effect of calcium ionophore, A23187, on rat muscle.
Topics: Animals; Calcimycin; Calcium; Cell Membrane; Creatine Kinase; Female; Freeze Fracturing; Leupeptins; Microscopy, Electron; Muscles; Muscular Dystrophies; Rats; Rats, Inbred Strains | 1986 |
Involvement of thiol proteases in galactosialidosis.
Topics: beta-Galactosidase; Cathepsin B; Cathepsin H; Cathepsins; Cells, Cultured; Coumarins; Cysteine Endopeptidases; Diazomethane; Dipeptides; Endopeptidases; Fibroblasts; Galactosidases; Humans; Leucine; Leupeptins; Neuraminidase; Protease Inhibitors | 1986 |
Immunoelectron microscopical localization of lysosomal beta-galactosidase and its precursor forms in normal and mutant human fibroblasts.
Topics: Antibodies; Antibodies, Monoclonal; beta-Galactosidase; Fibroblasts; G(M1) Ganglioside; Galactosidases; Gangliosidoses; Histocytochemistry; Humans; Immunochemistry; Leupeptins; Lysosomes; Metabolism, Inborn Errors; Microscopy, Electron; Neuraminidase; Subcellular Fractions | 1986 |
Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis.
Topics: Animals; Cathepsin B; Cathepsins; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Endopeptidases; Female; Fibrinolysis; Leucine; Leupeptins; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Peptide Hydrolases; Plasminogen Activators; Plasminogen Inactivators; Protease Inhibitors; Serine Endopeptidases; Thrombin; Thrombosis | 1986 |
The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism.
Topics: Animals; Calcimycin; Calcium; In Vitro Techniques; Leupeptins; Lysosomes; Male; Methylamines; Muscle Contraction; Muscle Proteins; Muscles; Protease Inhibitors; Rats; Rats, Inbred Strains | 1986 |
Evidence against a possible involvement of the serine, and thiol proteases in the exocytotic mechanism of catecholamine secretion in cultured bovine adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Calcimycin; Carbachol; Catecholamines; Cattle; Cells, Cultured; Cysteine Endopeptidases; Endopeptidases; Exocytosis; Kinetics; Leupeptins; Oligopeptides; Potassium; Serine Endopeptidases | 1986 |
Suppression of neurofilament degradation by protease inhibitors in experimental spinal cord injury.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Intermediate Filament Proteins; Leucine; Leupeptins; Male; Nerve Tissue Proteins; Neurofilament Proteins; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Cord Injuries | 1987 |
Partial purification and characterization of cysteine proteinases in eccrine sweat.
Topics: Benzoylarginine-2-Naphthylamide; Chromatography, Affinity; Chromatography, Gel; Cysteine Endopeptidases; Dithiothreitol; Eccrine Glands; Edetic Acid; Endopeptidases; Hydrogen-Ion Concentration; Isoelectric Focusing; Isoenzymes; Leucine; Leupeptins; Molecular Weight; Sweat; Sweat Glands | 1987 |
Biosynthesis and maturation of lactase-phlorizin hydrolase in the human small intestinal epithelial cells.
Topics: Antibodies, Monoclonal; beta-Galactosidase; Chemical Precipitation; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; Epithelium; Galactosidases; Glucosidases; Humans; Intestine, Small; Isoenzymes; Lactase-Phlorizin Hydrolase; Leupeptins; Monensin; Multienzyme Complexes; Protein Biosynthesis; Tunicamycin | 1987 |
A possible role for dephosphorylation in glucocorticoid receptor transformation.
Topics: Alkaline Phosphatase; Animals; Cell Line; Cytosol; Dexamethasone; Edetic Acid; Leupeptins; Mice; Phosphorylation; Pituitary Neoplasms; Protease Inhibitors; Receptors, Glucocorticoid; Sodium Fluoride | 1987 |
Import of rat liver mitochondrial transhydrogenase.
Topics: Animals; Biological Transport; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; In Vitro Techniques; Leupeptins; Liver; Mitochondria, Liver; NADH, NADPH Oxidoreductases; NADP Transhydrogenases; Phenanthrolines; Rats; Rhodamines | 1988 |
The presence of a reduced amount of 32-kd "protective" protein is a distinct biochemical finding in late infantile galactosialidosis.
Topics: beta-Galactosidase; Carbohydrate Metabolism, Inborn Errors; Cells, Cultured; Fibroblasts; Galactosidases; Humans; Infant; Leupeptins; Molecular Weight; Neuraminidase; Proteins | 1988 |
Inhibition of early but not late proteolytic processing events leads to the missorting and oversecretion of precursor forms of lysosomal enzymes in Dictyostelium discoideum.
Topics: alpha-Mannosidase; Antipain; beta-Glucosidase; Biological Transport; Cell Compartmentation; Cysteine Proteinase Inhibitors; Dictyostelium; Golgi Apparatus; Hexosaminidases; Leupeptins; Lysosomes; Mannosidases; Molecular Weight; Protein Processing, Post-Translational; Time Factors | 1988 |
Reduction of muscle protein degradation by leupeptin in acutely uremic rats.
Topics: Acute Disease; Animals; Leupeptins; Male; Methylhistidines; Muscle Proteins; Muscles; Nephrectomy; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Urea; Uremia | 1988 |
Subcellular distribution of protein kinase C in rat adrenal glomerulosa cells.
Topics: Angiotensin II; Animals; Calcium; Cytosol; Leupeptins; Phenylmethylsulfonyl Fluoride; Phospholipids; Protein Kinase C; Rats; Rats, Inbred Strains; Subcellular Fractions; Tetradecanoylphorbol Acetate; Zona Glomerulosa | 1988 |
Distribution of protein disulfide isomerase in rat hepatocytes.
Topics: Animals; Cell Membrane; Endoplasmic Reticulum; Gold; Immunoblotting; Immunohistochemistry; Isomerases; Leupeptins; Liver; Lysosomes; Male; Microscopy, Electron; Microsomes, Liver; Nuclear Envelope; Protein Disulfide-Isomerases; Rats; Rats, Inbred Strains; Staphylococcal Protein A | 1988 |
Ferritin iron kinetics and protein turnover in K562 cells.
Topics: Animals; Cell Line; Deferoxamine; Electrophoresis, Polyacrylamide Gel; Ferritins; Iron; Kinetics; Leupeptins; Pentetic Acid; Proteins | 1988 |
Degradation of aspartate aminotransferase in rat liver lysosomes.
Topics: Animals; Aspartate Aminotransferases; Blotting, Western; Isoenzymes; Leupeptins; Liver; Lysosomes; Molecular Weight; Rats | 1988 |
Influence of leupeptin on protein and amino-acid metabolism in septic rats.
Topics: Amino Acids; Animals; Bacterial Infections; Body Weight; Eating; Leupeptins; Liver; Muscles; Oligopeptides; Proteins; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
Increased mortality in septic rats after leupeptin application.
Topics: Animals; Bacterial Infections; Body Weight; Creatinine; Leupeptins; Liver; Male; Muscles; Oligopeptides; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
Inhibition of EGF processing in responsive and nonresponsive human fibroblasts.
Topics: Animals; Cells, Cultured; Chloroquine; Epidermal Growth Factor; Humans; Iodine Radioisotopes; Kinetics; Leupeptins; Lung; Male; Mice; Protein Processing, Post-Translational; Skin | 1988 |
Regulation of the production of a prolactin-like protein (MRP/PLF) in 3T3 cells and in the mouse placenta.
Topics: Ammonium Chloride; Animals; Antipain; Cell Line; Epidermal Growth Factor; Fibroblast Growth Factors; Glycoproteins; Glycosylation; Intercellular Signaling Peptides and Proteins; Kinetics; Leupeptins; Mice; Monensin; Placenta; Prolactin; RNA, Messenger | 1988 |
Selective inhibition of antigen presentation to cloned T cells by protease inhibitors.
Topics: Animals; Antigen-Presenting Cells; Antipain; Clone Cells; Histocompatibility Antigens Class II; Immunosuppressive Agents; Leupeptins; Metalloendopeptidases; Mice; Oligopeptides; Protease Inhibitors; T-Lymphocytes | 1988 |
Processing requirements for T cell activation by Mycoplasma arthritidis-derived mitogen.
Topics: Ammonium Chloride; Antigen-Presenting Cells; Chloroquine; Formaldehyde; Leupeptins; Lymphocyte Activation; Lysosomes; Macrophages; Mitogens; Monensin; Mycoplasma; Polymers; T-Lymphocytes | 1988 |
Thrombin-like inhibitory action of trypsin and trypsin-like proteases on human platelet adenylate cyclase.
Topics: Acrosin; Adenylyl Cyclase Inhibitors; Animals; Blood Platelets; Cattle; Epinephrine; Guanosine Triphosphate; Humans; Leupeptins; Male; Peptide Hydrolases; Spermatozoa; Thrombin; Trypsin | 1988 |
Role for intracellular proteases in the processing and transport of class II HLA antigens.
Topics: Biological Transport; Chloroquine; HLA-D Antigens; Humans; Leupeptins; Molecular Weight; Monensin; Peptide Hydrolases; Protein Processing, Post-Translational | 1988 |
Inhibitory effect of a protease inhibitor, leupeptin, on the development of influenza pneumonia, mediated by concomitant bacteria.
Topics: Animals; Endopeptidases; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral; Influenza A virus; Leupeptins; Metalloendopeptidases; Mice; Oligopeptides; Orthomyxoviridae Infections; Pneumonia, Staphylococcal; Protease Inhibitors; Protein Processing, Post-Translational; Staphylococcus aureus; Virus Replication | 1987 |
Pharmacological protection against the toxicity of N-methyl-D-aspartate in immature rat cerebellar slices.
Topics: Animals; Aspartic Acid; Aspirin; Calcium Channel Blockers; Cerebellum; Female; In Vitro Techniques; Indomethacin; Kynurenic Acid; Leupeptins; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Taurine | 1987 |
Evidence that cathepsin B contributes to skeletal muscle protein breakdown during sepsis.
Topics: Animals; Bacterial Infections; Cathepsin B; Leupeptins; Male; Muscle Proteins; Muscles; Rats; Rats, Inbred Strains | 1988 |
Degradation of the precursor of mitochondrial aspartate aminotransferase in chicken embryo fibroblasts.
Topics: Adenosine Triphosphate; Animals; Antipain; Aspartate Aminotransferases; Chick Embryo; Cytosol; Enzyme Precursors; Fibroblasts; Half-Life; Leupeptins; Methylamines; Mitochondria; Monensin | 1988 |
Degradation of endocytosed dermatan sulfate proteoglycan in human fibroblasts.
Topics: Ammonium Chloride; Biological Transport; Cells, Cultured; Chondroitin; Chondroitin Sulfate Proteoglycans; Cycloheximide; Dermatan Sulfate; Diazomethane; Endocytosis; Fibroblasts; Half-Life; Humans; Kinetics; Leucine; Leupeptins; Lysosomes; Molecular Weight; Protease Inhibitors; Proteoglycans; Sulfates | 1988 |
Effects of indomethacin and leupeptin on muscle cathepsin B activity and protein degradation during sepsis.
Topics: Animals; Bacterial Infections; Cathepsin B; Indomethacin; Leupeptins; Muscle Proteins; Muscles; Oligopeptides; Reference Values | 1988 |
Thrombin inhibition with dipeptidyl argininals.
Topics: Antipain; Blood Coagulation; Kinetics; Leupeptins; Oligopeptides; Thrombin | 1988 |
Treatment of experimental autoimmune myasthenia gravis in rabbits with leupeptin, a protease inhibitor.
Topics: Animals; Antibodies; Autoimmune Diseases; Leupeptins; Male; Myasthenia Gravis; Oligopeptides; Rabbits; Receptors, Cholinergic | 1987 |
Protease and cyclooxygenase inhibitors synergistically prevent activation of human platelets.
Topics: Blood Platelets; Collagen; Humans; In Vitro Techniques; Indomethacin; Leupeptins; Oligopeptides; Platelet Aggregation; Secretory Rate; Serotonin; Thrombin | 1986 |
The effects of ascorbic acid on the intracellular metabolism of iron and ferritin.
Topics: Animals; Ascorbic Acid; Cell Line; Deferoxamine; Dose-Response Relationship, Drug; Ferritins; Iron; Leukemia, Erythroblastic, Acute; Leupeptins; Methionine | 1986 |
Phosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol 12-myristate 13-acetate.
Topics: Cytoskeletal Proteins; Humans; Leupeptins; Molecular Weight; Neutrophils; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1987 |
Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation.
Topics: Acetamides; Animals; Calcium; Cell Differentiation; Cells, Cultured; Hemoglobins; Leukemia, Erythroblastic, Acute; Leupeptins; Mice; Phospholipids; Protein Kinase C; Tetradecanoylphorbol Acetate | 1987 |
Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion.
Topics: Animals; Bile; Chloroquine; Leupeptins; Liver; Male; Organoids; Peptides; Rats; Transforming Growth Factors | 1987 |
Inhibition of H-ras oncogene transformation of NIH3T3 cells by protease inhibitors.
Topics: alpha 1-Antitrypsin; Aminocaproic Acid; Animals; Antipain; Cell Division; Cell Line; Drug Resistance; Leupeptins; Neomycin; Oncogenes; Plasmids; Protease Inhibitors; Transfection | 1987 |
Target-selective cytotoxicity of methotrexate conjugated with monoclonal anti-MM46 antibody.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Immunotoxins; Leupeptins; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C3H | 1987 |
Schistosoma mansoni: purification and characterization of the major acidic proteinase from adult worms.
Topics: Animals; Chromatography, Gel; Cysteine Endopeptidases; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Female; Helminth Proteins; Hemoglobins; Hydrogen-Ion Concentration; Isoelectric Point; Kinetics; Leupeptins; Male; Molecular Weight; Peptides; Protease Inhibitors; Schistosoma mansoni; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1986 |
Morphometric assessment of drug effects in experimental spinal cord injury.
Topics: Animals; Axons; Leucine; Leupeptins; Male; Methylprednisolone; Methylprednisolone Hemisuccinate; Rats; Rats, Inbred Strains; Spinal Cord Injuries | 1986 |
Pinocytosis and degradation of exogenous proteins by cystinotic fibroblasts.
Topics: Cells, Cultured; Cysteine Endopeptidases; Cystinosis; Endopeptidases; Humans; Leupeptins; Lysosomes; Pinocytosis; Proteins; Skin | 1986 |
Inhibition of proteolytic enzymes in the in vitro amnion model for basement membrane invasion.
Topics: Amnion; Animals; Basement Membrane; Blood Physiological Phenomena; Cathepsin B; Cathepsins; Cell Membrane; Cysteine Endopeptidases; Endopeptidases; Female; Humans; In Vitro Techniques; Leupeptins; Melanoma; Mice; Neoplasm Invasiveness; Plasminogen Activators; Pregnancy; Protease Inhibitors; Serine Endopeptidases; Urokinase-Type Plasminogen Activator | 1986 |
A protease acting on the estrogen receptor may modify its action in the adult rabbit epididymis.
Topics: Aging; Animals; Cell Nucleus; Centrifugation, Density Gradient; Epididymis; Estradiol; Estrogens; Genitalia, Male; In Vitro Techniques; Leupeptins; Male; Orchiectomy; Peptide Hydrolases; Rabbits; Receptors, Estrogen | 1986 |
Physiological role of thiol proteases in thyroid hormone secretion.
Topics: Acid Phosphatase; Animals; Centrifugation, Density Gradient; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Leupeptins; Lysosomes; Male; Rats; Rats, Inbred Strains; Thyroid Gland; Thyroxine; Triiodothyronine | 1986 |
Induction and inhibition of cathepsin B and hemoglobin-hydrolase activity in murine B16 melanoma by thiol protease inhibitors.
Topics: Animals; Antipain; Cathepsin B; Kinetics; Leucine; Leupeptins; Melanoma, Experimental; Mice; Oligopeptides; Peptide Hydrolases; Protease Inhibitors | 1986 |
The bovine lens neutral proteinase comprises a family of cysteine-dependent proteolytic activities.
Topics: Animals; Cattle; Cysteine; Endopeptidases; Hydrolysis; Lens, Crystalline; Leupeptins; Neprilysin; Nitrobenzenes; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Substrate Specificity; Trypsin | 1986 |
Plasmodium falciparum: protease inhibitors and inhibition of erythrocyte invasion.
Topics: Animals; Chymotrypsin; Erythrocytes; Humans; In Vitro Techniques; Leupeptins; Oligopeptides; Plasmodium falciparum; Protease Inhibitors; Trypsin | 1986 |
Effect of leupeptin, a protease inhibitor, on dopa decarboxylase and protease activities in homogenates of submandibular salivary glands from young rats.
Topics: Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Dopa Decarboxylase; Female; Leupeptins; Male; Oligopeptides; Peptide Hydrolases; Rats; Rats, Inbred Strains; Submandibular Gland | 1986 |
Biosynthesis and maturation of glucocerebrosidase in Gaucher fibroblasts.
Topics: Cell Line; Cross Reactions; Fibroblasts; Gaucher Disease; Glucosidases; Glucosylceramidase; Humans; Immunosorbent Techniques; Leupeptins; Methionine; Molecular Weight; Mutation | 1987 |
Leukocyte protease activities in myotonic dystrophy: studies on effects of protease inhibitors.
Topics: Aspartic Acid Endopeptidases; Endopeptidases; Granulocytes; Humans; Leukocytes; Leupeptins; Mercuric Chloride; Monocytes; Myotonic Dystrophy; Neprilysin; Oligopeptides; Pepstatins; Protease Inhibitors | 1987 |
Significant effects of Z-Gln-Val-Val-OME, common sequences of thiol proteinase inhibitors on thiol proteinases.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cathepsin B; Cystatins; Kininogens; Leupeptins; Oligopeptides; Papain; Protease Inhibitors; Proteins; Structure-Activity Relationship | 1987 |
A tripeptide protease inhibitor attenuates conditioned avoidance behavior.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Depression, Chemical; Injections, Intraventricular; Leupeptins; Male; Memory; Oligopeptides; Protease Inhibitors; Time Factors | 1987 |
A putative protein-sequestration site involving intermediate filaments for protein degradation by autophagy. Studies with microinjected purified glycolytic enzymes in 3T3-L1 cells.
Topics: Autophagy; Binding Sites; Cell Fractionation; Cell Line; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Glyceraldehyde-3-Phosphate Dehydrogenases; Intermediate Filaments; L-Lactate Dehydrogenase; Leupeptins; Microinjections; Phagocytosis; Proteins; Pyruvate Kinase; Serum Albumin, Bovine | 1987 |
Mode of action of bestatin and leupeptin to induce the accumulation of acid soluble peptides in rat liver in vivo and the properties of the accumulated peptides. The important role of bestatin- and leupeptin-sensitive proteases in the protein degradation
Topics: Aminopeptidases; Animals; Glucagon; Kinetics; Leucine; Leupeptins; Liver; Male; Models, Biological; Oligopeptides; Peptide Mapping; Peptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Solubility | 1987 |
The role of microtubules in the phagocytosis of collagen by fibroblasts.
Topics: Animals; Bone and Bones; Cells, Cultured; Colchicine; Collagen; Cytochalasin B; Cytoplasmic Granules; Fibroblasts; Leupeptins; Mice; Microscopy, Electron; Microtubules; Phagocytosis; Vacuoles; Vinblastine | 1987 |
[Effect of leupeptin on protein uptake and the degradation of the visceral yolk sac epithelium of the rat].
Topics: Animals; Epithelium; Female; Horseradish Peroxidase; Leupeptins; Oligopeptides; Pregnancy; Proteins; Rats; Rats, Inbred Strains; Yolk Sac | 1987 |
Sperm chymotrypsin-like enzymes of different inhibitor-susceptibility as lysins in ascidians.
Topics: Animals; Anti-Bacterial Agents; Chymotrypsin; Enzyme Inhibitors; Fertilization; Leupeptins; Male; Oligopeptides; Peptides; Spermatozoa; Urochordata | 1987 |
Enhancement of neuromuscular recovery after nerve repair in primates.
Topics: Animals; Axons; Blood Coagulation; Cebus; Leupeptins; Median Nerve; Muscles; Myelin Sheath; Nerve Regeneration; Neural Conduction; Oligopeptides | 1987 |
Leupeptin inhibits the transformation of glucocorticoid receptor.
Topics: Adrenalectomy; Animals; Cellulose; Centrifugation, Density Gradient; Chromatography, Affinity; Cytosol; DNA; Kinetics; Leupeptins; Liver; Male; Molybdenum; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Triamcinolone Acetonide | 1987 |
Ascorbic acid inhibits lysosomal autophagy of ferritin.
Topics: Ascorbic Acid; Cell Line; Cytoplasm; Ferritins; Glucuronidase; Iron; Leupeptins; Lysosomes; Proteins | 1987 |
Effect of leupeptin on platelet aggregation, fibrin formation and amidolysis induced by thrombin.
Topics: Blood Platelets; Dipeptides; Fibrin; Humans; In Vitro Techniques; Leupeptins; Oligopeptides; Platelet Aggregation; Thrombin | 1987 |
Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity--formation of crinosomes.
Topics: Animals; Autophagy; Chloroquine; Leupeptins; Lipid Metabolism; Liver; Lysosomes; Microscopy, Electron; Phagocytosis; Proteins; Rats; Vacuoles; Vinblastine | 1987 |
Influence of a calcium dependent protease inhibitor on platelet activation and secretion.
Topics: Blood Coagulation; Blood Platelets; Calcium; Cytosol; Dipeptides; Glycoproteins; Humans; Hydrolysis; Leupeptins; Oligopeptides; Platelet Aggregation; Serotonin; Therapeutic Irrigation; Thrombin | 1987 |
Vascular permeability changes by proteinase inhibitors in carrageenin-induced inflammation in rats.
Topics: Animals; Capillary Permeability; Carrageenan; Inflammation; Kinetics; Leupeptins; Protease Inhibitors; Rats; Rats, Inbred Strains; Time Factors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1986 |
Sustained proteolysis is required for human platelet activation by thrombin.
Topics: Blood Platelets; Humans; Indomethacin; Inositol; Kinetics; Leupeptins; Platelet Aggregation; Serotonin; Thrombin | 1986 |
Evidence for a specific estradiol binding site on rat pituitary membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Diethylstilbestrol; Dihydrotestosterone; Estradiol; Estriol; Estrone; Female; Hydrocortisone; Kinetics; Leupeptins; Pituitary Gland, Anterior; Progesterone; Rats; Rats, Inbred Strains; Temperature | 1986 |
Effects of leupeptin on endocytosis and membrane recycling in rat visceral yolk-sac endoderm.
Topics: Animals; Cell Membrane; Cells, Cultured; Concanavalin A; Endocytosis; Endoderm; Horseradish Peroxidase; Intracellular Membranes; Leupeptins; Lysosomes; Oligopeptides; Rats; Yolk Sac | 1986 |
Influence of agents that alter lysosomal function on fetal mouse hearts recovering from anoxia and substrate depletion.
Topics: Animals; Chloroquine; Female; Fetus; Hydrocortisone; Hypoxia; Kinetics; Leupeptins; Lysosomes; Mice; Microscopy, Electron; Myocardium; Oligopeptides; Organ Culture Techniques; Pregnancy; Vacuoles | 1986 |
Acidic lens-protein-degrading activity in aqueous humour.
Topics: Animals; Aqueous Humor; Cataract; Cattle; Crystallins; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leupeptins; Pepstatins; Protease Inhibitors | 1986 |
Preparation and purification of the proteinase inhibitor, leupeptin, from culture filtrates of Streptomyces lavendulae.
Topics: Carbon Radioisotopes; Culture Media; Kinetics; Leupeptins; Oligopeptides; Streptomyces; Tritium | 1986 |
Assay of plasma leupeptin using the reversible binding of leupeptin to bovine pancreatic trypsin.
Topics: Animals; Binding, Competitive; Cattle; Dogs; Kinetics; Leupeptins; Male; Oligopeptides; Pancreas; Protein Binding; Species Specificity; Trypsin | 1986 |
Secretion-coupled protein degradation: studies on mammary casein.
Topics: Adenine; Amino Acids; Animals; Biological Transport; Caseins; Colchicine; Cytochalasin B; Female; Leupeptins; Mammary Glands, Animal; Organ Culture Techniques; Rabbits; Tunicamycin | 1986 |
Processing and estrogen regulation of the 52-kilodalton protein inside MCF7 breast cancer cells.
Topics: Ammonium Chloride; Antibodies, Monoclonal; Breast Neoplasms; Cell Compartmentation; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation; Glycosylation; Humans; Leupeptins; Molecular Weight; Monensin; Neoplasm Proteins; Protein Processing, Post-Translational | 1986 |
Leucine aminopeptidase and hatching of Schistosoma mansoni eggs.
Topics: Animals; Cold Temperature; Darkness; Leucine; Leucyl Aminopeptidase; Leupeptins; Ovum; Schistosoma mansoni; Sodium Chloride | 1986 |
Characterization of Ca2+-activated, phospholipid-dependent protein kinase C/protein kinase M in guinea pig peritoneal exudate macrophages.
Topics: Animals; Calcium; Cell Compartmentation; Diglycerides; Enzyme Activation; Guinea Pigs; Kinetics; Leupeptins; Macrophages; Peptide Fragments; Peritoneal Cavity; Phorbol Esters; Phosphatidylserines; Phospholipids; Protein Kinase C | 1986 |
In vitro cytotoxicity of a human serum albumin-mediated conjugate of methotrexate with anti-MM46 monoclonal antibody.
Topics: Ammonium Chloride; Animals; Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry, Physical; Cytotoxicity, Immunologic; Leupeptins; Methotrexate; Mice; Mice, Inbred C3H; Serum Albumin | 1987 |
On the fates of receptor-bound ovine luteinizing hormone and human chorionic gonadotropin in cultured Leydig tumor cells. Demonstration of similar rates of internalization.
Topics: Ammonium Chloride; Animals; Biological Transport; Chorionic Gonadotropin; Endocytosis; Kinetics; Leupeptins; Leydig Cell Tumor; Luteinizing Hormone; Male; Mice; Receptors, LH; Sheep; Sodium | 1987 |
Degradation of short- and long-lived proteins in perfused liver and in isolated autophagic vacuoles--lysosomes.
Topics: Animals; Autophagy; Chloroquine; Half-Life; Leupeptins; Liver; Lysosomes; Male; Phagocytosis; Proteins; Rats; Rats, Inbred Strains; Vacuoles | 1987 |
Leupeptin and chymostatin inhibit mammalian protein methylesterase activity.
Topics: Animals; Kinetics; Leupeptins; Oligopeptides; Protein Methyltransferases; Rats | 1987 |
Competitive inhibition of [3H]dexamethasone binding to mammary glucocorticoid receptor by leupeptin.
Topics: Animals; Binding, Competitive; Centrifugation, Density Gradient; Dexamethasone; Female; Goats; Kinetics; Leupeptins; Mammary Glands, Animal; Oligopeptides; Receptors, Glucocorticoid | 1987 |
Regulation of Ca2+-dependent protein turnover in skeletal muscle by thyroxine.
Topics: Adenine; Animals; Calcium; Dantrolene; Female; Leupeptins; Methylamines; Muscle Proteins; Muscles; Potassium; Rats; Rats, Inbred Strains; Thyroxine | 1986 |
Effects of proteinase inhibitors on preimplantation embryos in the rat.
Topics: Animals; Anti-Bacterial Agents; Antipain; Blastocyst; Cystatins; Embryonic Development; Enzyme Inhibitors; Female; Glycopeptides; Leupeptins; Oligopeptides; Pepstatins; Peptides; Pregnancy; Protease Inhibitors; Rats; Rats, Inbred Strains | 1985 |
Pharmacological dissociation of memory: anisomycin, a protein synthesis inhibitor, and leupeptin, a protease inhibitor, block different learning tasks.
Topics: Animals; Anisomycin; Avoidance Learning; Discrimination Learning; Injections, Subcutaneous; Leupeptins; Male; Memory; Olfactory Pathways; Oligopeptides; Protease Inhibitors; Pyrrolidines; Rats; Rats, Inbred Strains | 1985 |
Regulation of protein breakdown by epidermal growth factor in A431 cells.
Topics: Adenine; Ammonium Chloride; Autolysis; Carcinoma, Squamous Cell; Cell Line; Cycloheximide; Epidermal Growth Factor; Fibroblasts; Humans; Hydrogen-Ion Concentration; Insulin; Leupeptins; Lung; Proteins; Time Factors; Vinblastine | 1985 |
[Inhibition of extracellular yeast proteinases by pepstatin A and leupeptin in the plate test].
Topics: Agar; Blastomyces; Candida; Depression, Chemical; Endopeptidases; Geotrichum; Leupeptins; Mitosporic Fungi; Oligopeptides; Pepstatins; Species Specificity | 1985 |
Lysosomal digestion of thyroglobulin: role of cathepsin D and thiol proteases.
Topics: Animals; Cathepsin D; Cysteine Endopeptidases; Endopeptidases; Hydrogen-Ion Concentration; Iodine; Leupeptins; Lysosomes; Mercaptoethanol; Monoiodotyrosine; Pepstatins; Pronase; Protease Inhibitors; Swine; Thyroglobulin | 1985 |
Schistosoma japonicum: biochemistry and cytochemistry of dipeptidyl aminopeptidase-II-like activity in adults.
Topics: Animals; Cecum; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Hot Temperature; Hydrogen-Ion Concentration; Isoflurophate; Kinetics; Leupeptins; Octoxynol; Polyethylene Glycols; Schistosoma japonicum | 1985 |
Isolation of two forms of the high-molecular-mass serine protease, ingensin, from porcine skeletal muscle.
Topics: Animals; Antipain; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, High Pressure Liquid; Coumarins; Cysteine Endopeptidases; Endopeptidases; Isoenzymes; Leucine; Leupeptins; Multienzyme Complexes; Muscles; Oligopeptides; Pepstatins; Proteasome Endopeptidase Complex; Sodium Dodecyl Sulfate; Swine | 1985 |
Degradation of short- and long-time labelled proteins by rat liver lysosomes.
Topics: Animals; Carbon Radioisotopes; Fructose-Bisphosphate Aldolase; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Male; Microscopy, Electron; Peptide Hydrolases; Proteins; Radioisotope Dilution Technique; Rats | 1985 |
Comparison of proteolysis in perfused rat liver and in isolated autophagic vacuoles.
Topics: Animals; Autophagy; Chloroquine; Leupeptins; Liver; Lysosomes; Microscopy, Electron; Organoids; Peptide Hydrolases; Phagocytosis; Rats; Vacuoles | 1985 |
The role of lysosomes in the degradation of myofibrillar and non-myofibrillar proteins in heart.
Topics: Adenine; Animals; Chloroquine; Fetus; Insulin; Kinetics; Leupeptins; Lysosomes; Mice; Myocardium; Myofibrils; Proteins | 1985 |
Degradation of insulin by human fibroblasts: effects of inhibitors of pinocytosis and lysosomal activity.
Topics: 2,4-Dinitrophenol; Ammonium Chloride; Anti-Bacterial Agents; Biological Transport; Cells, Cultured; Dinitrophenols; Fibroblasts; Humans; Insulin; Iodine Radioisotopes; Kinetics; Leupeptins; Lysosomes; Pinocytosis; Povidone-Iodine; Skin; Sodium Fluoride | 1985 |
Biosynthesis and intracellular transport of alpha-glucosidase and cathepsin D in normal and mutant human fibroblasts.
Topics: alpha-Glucosidases; Ammonium Chloride; Biological Transport; Cathepsin D; Cell Line; Centrifugation, Density Gradient; Dipeptides; Fibroblasts; Glucosidases; Humans; Immunochemistry; Leupeptins; Lysosomes; Mutation; Organoids; Skin | 1985 |
Acidic lens protein degrading activity in bovine ciliary body.
Topics: Animals; Cattle; Chromatography; Ciliary Body; Crystallins; Cysteine; Hydrogen-Ion Concentration; Leupeptins; Pepstatins; Protease Inhibitors | 1985 |
Diacylglycerol lipase activity in human platelet intracellular and surface membranes. Some kinetic properties and fatty acid specificity.
Topics: Blood Platelets; Cell Membrane; Centrifugation, Density Gradient; Egtazic Acid; Fatty Acids; Glutathione; Humans; Intracellular Membranes; Kinetics; Leupeptins; Lipoprotein Lipase; Substrate Specificity; Trifluoperazine | 1985 |
Platelet cytoskeleton alpha-actinin in normal and thrombasthenic platelets: distribution and immunologic characterization.
Topics: Actinin; Animals; Blood Platelet Disorders; Blood Platelets; Cross Reactions; Edetic Acid; Fibroblasts; Humans; Immunoelectrophoresis; Leupeptins; Microscopy, Electron; Muscle, Smooth; Rabbits; Skin | 1985 |
A study of the low beta-galactosidase activity in cystinotic fibroblasts: effects of cysteamine.
Topics: beta-Galactosidase; Cells, Cultured; Cysteamine; Cystinosis; Fibroblasts; Galactosidases; Humans; Hydrolysis; Leupeptins | 1985 |
Effect of inhibitors of proteolysis and arachidonic acid metabolism on burn-induced protein breakdown.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Hindlimb; Ibuprofen; In Vitro Techniques; Indomethacin; Leupeptins; Lysosomes; Muscles; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Proteins; Quinacrine; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Evidence for two pathways for stimulation of collagenolysis in bone.
Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Cartilage; In Vitro Techniques; Interleukin-1; Leupeptins; Lipopolysaccharides; Mice; Osteoclasts; Parathyroid Hormone; Proline | 1985 |
Biochemical evidence for the presence of an actin protein in Tetrahymena pyriformis.
Topics: Actins; Animals; Chromatography, Affinity; Deoxyribonuclease I; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Leupeptins; Microscopy, Electron; Molecular Weight; Protein Binding; Tetrahymena pyriformis | 1985 |
Regulation of myofibrillar accumulation in chick muscle cultures: evidence for the involvement of calcium and lysosomes in non-uniform turnover of contractile proteins.
Topics: Animals; Calcimycin; Calcium; Cells, Cultured; Chickens; Chloroquine; Contractile Proteins; Leupeptins; Lysosomes; Methylamines; Muscle Proteins; Muscles; Myosins; Tropomyosin; Troponin | 1985 |
Molecular forms of GM2-activator protein. A study on its biosynthesis in human skin fibroblasts.
Topics: Cells, Cultured; Endocytosis; Enzyme-Linked Immunosorbent Assay; Fibroblasts; G(M2) Activator Protein; G(M2) Ganglioside; Gangliosides; Gangliosidoses; Humans; Kinetics; Leucine; Leupeptins; Lysosomes; Pepstatins; Phenylmethylsulfonyl Fluoride; Protein Biosynthesis; Skin; Tritium | 1985 |
Stimulation of rat Sertoli cell adenylate cyclase by germ cells in vitro.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Cells, Cultured; Enzyme Activation; Follicle Stimulating Hormone; Germ Cells; In Vitro Techniques; Indomethacin; Isoproterenol; Leupeptins; Male; Propranolol; Rats; Sertoli Cells | 1985 |
Muscle damage induced by the ionophore A23187 can be prevented by prostaglandin inhibitors and leupeptin.
Topics: Actin Cytoskeleton; Animals; Calcimycin; Calcium; Leupeptins; Muscle Contraction; Muscles; Oligopeptides; Prostaglandin Antagonists; Rana pipiens | 1985 |
Discrepancies in the catabolic pathways of human and rat high-density lipoprotein apolipoprotein A-I in the rat.
Topics: Animals; Apolipoprotein A-I; Apolipoproteins A; Humans; Kidney; Kinetics; Leupeptins; Lipoproteins, HDL; Liver; Male; Rats; Rats, Inbred Strains; Species Specificity; Tissue Distribution | 1985 |
Human IgA as a heterovalent ligand: switching from the asialoglycoprotein receptor to secretory component during transport across the rat hepatocyte.
Topics: Animals; Asialoglycoprotein Receptor; Bile; Biological Transport, Active; Cell Compartmentation; Galactose Oxidase; Humans; Immunoglobulin A; Immunoglobulin Fragments; Leupeptins; Ligands; Liver; Lysosomes; Male; Protein Binding; Rats; Rats, Inbred Strains; Receptors, Fc; Receptors, Immunologic; Secretory Component; Species Specificity; Time Factors | 1986 |
Inhibition of the growth of human coronavirus 229E by leupeptin.
Topics: Cell Line; Coronaviridae; Humans; Leupeptins; Oligopeptides; Protease Inhibitors; Viral Plaque Assay; Virus Replication | 1985 |
Effect of amino acids and cycloheximide on changes caused by vinblastine, leupeptin and methylamine in the autophagic/lysosomal system of mouse hepatocytes in vivo.
Topics: Amino Acids; Animals; Autophagy; Cycloheximide; Leupeptins; Liver; Lysosomes; Male; Methylamines; Mice; Organoids; Phagocytosis; Proteins; Vacuoles; Vinblastine | 1985 |
Formation of a 55 000-weight cross-linked beta crystallin dimer in the Ca2+-treated lens. A model for cataract.
Topics: Animals; Calcium; Cataract; Cross Reactions; Crystallins; Electrophoresis, Polyacrylamide Gel; Lens, Crystalline; Leupeptins; Macromolecular Substances; Molecular Weight; Rabbits; Vimentin | 1985 |
Participation of lysosomes in basal proteolysis in perfused rat liver. Discrepancy between leupeptin-induced lysosomal enlargement and inhibition of proteolysis.
Topics: Amino Acids; Animals; Cytoplasmic Granules; Leupeptins; Liver; Lysosomes; Oligopeptides; Proteins; Rats | 1985 |
Studies in vivo and in vitro on the uptake and degradation of soluble collagen alpha 1(I) chains in rat liver endothelial and Kupffer cells.
Topics: Animals; Antimetabolites; Cells, Cultured; Collagen; Endothelium; Iodine Radioisotopes; Kinetics; Kupffer Cells; Leupeptins; Liver; Male; Rats; Rats, Inbred Strains | 1985 |
Metabolism of [3H]leupeptin by rat liver.
Topics: Animals; Binding, Competitive; Biological Transport, Active; Chloroquine; Leupeptins; Liver; Lysosomes; Male; Oligopeptides; Perfusion; Rats; Rats, Inbred Strains; Temperature | 1985 |
Olfactory discrimination learning is blocked by leupeptin, a thiol protease inhibitor.
Topics: Animals; Brain; Calcium; Depression, Chemical; Discrimination Learning; Hippocampus; Injections, Intraventricular; Leupeptins; Male; Memory; Olfactory Pathways; Oligopeptides; Rats; Smell | 1985 |
Affinity chromatography of urokinase on an agarose derivative coupled with pyroglutamyl-lysyl-leucyl-argininal.
Topics: Chemical Phenomena; Chemistry; Chromatography, Affinity; Humans; Leupeptins; Ligands; Oligopeptides; Urokinase-Type Plasminogen Activator | 1985 |
Inhibition of intracellular degradation of proteoglycans by leupeptin in rat ovarian granulosa cells.
Topics: Animals; Female; Gonadotropins, Equine; Granulosa Cells; Kinetics; Leupeptins; Oligopeptides; Proteoglycans; Rats; Sulfur Radioisotopes | 1985 |
Comparative effects of cathepsin inhibitors on rat embryonic development in vitro. Evidence that cathepsin D is unimportant in the proteolytic function of yolk sac.
Topics: Animals; Cathepsin D; Cathepsins; Cells, Cultured; Embryonic and Fetal Development; Hemoglobins; Hydrogen-Ion Concentration; Leupeptins; Pepstatins; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Time Factors; Yolk Sac | 1985 |
Is a nicotinic influence involved in denervation-induced depolarization of muscle?
Topics: Animals; Electrophysiology; Leupeptins; Male; Membrane Potentials; Motor Endplate; Muscle Denervation; Muscles; Nicotine; Organ Culture Techniques; Parasympatholytics; Protease Inhibitors; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Rat mammary gland in culture secretes a stable high molecular weight form of cathepsin L.
Topics: Animals; Cathepsin B; Cathepsin L; Cathepsins; Culture Techniques; Cysteine Endopeptidases; Diazomethane; Endopeptidases; Female; Hydrogen-Ion Concentration; Lactation; Leupeptins; Mammary Glands, Animal; Molecular Weight; Pregnancy; Rats; Rats, Inbred Strains; Substrate Specificity | 1985 |
Specific targeting of high density lipoproteins to liver hepatocytes by incorporation of a tris-galactoside-terminated cholesterol derivative.
Topics: Animals; Chloroquine; Cholesterol Esters; Endothelium; Humans; In Vitro Techniques; Kinetics; Kupffer Cells; Leupeptins; Lipoproteins, HDL; Lipoproteins, LDL; Liver; Male; Rats; Rats, Inbred Strains; Receptors, LDL | 1985 |
Leupeptin selectively inhibits human platelet responses induced by thrombin and trypsin; a role for proteolytic activation of phospholipase C.
Topics: Adult; Blood Platelets; Enzyme Activation; Humans; In Vitro Techniques; Inositol Phosphates; Leupeptins; Middle Aged; Oligopeptides; Phosphatidic Acids; Phosphorylation; Platelet Aggregation; Serotonin; Thrombin; Trypsin; Trypsin Inhibitors; Type C Phospholipases | 1985 |
Alleviation of axonal damage in acute spinal cord injury by a protease inhibitor: automated morphometric analysis of drug-effects.
Topics: Animals; Leupeptins; Male; Oligopeptides; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Cord Injuries; Wounds, Nonpenetrating | 1985 |
The digestion of phagocytosed collagen is inhibited by the proteinase inhibitors leupeptin and E-64.
Topics: 2,2'-Dipyridyl; Animals; Ascorbic Acid; Bone and Bones; Collagen; Culture Techniques; Cycloheximide; Cytochalasin B; Fibroblasts; Leucine; Leupeptins; Mice; Microscopy, Electron; Oligopeptides; Phagocytosis; Vacuoles | 1985 |
Reversibility of the stabilization effect of sodium molybdate on uterine estrogen and progesterone receptors of the vervet monkey.
Topics: Animals; Chlorocebus aethiops; Cytosol; Female; In Vitro Techniques; Kinetics; Leupeptins; Molybdenum; Phenylmethylsulfonyl Fluoride; Receptors, Estrogen; Receptors, Progesterone; Uterus | 1985 |
The fate of the surface protein gp70 during entry of retrovirus into mouse fibroblasts.
Topics: Ammonium Chloride; Animals; Cell Line; Chloroquine; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Glucosamine; Kinetics; Leucine; Leupeptins; Mice; Retroviridae; Retroviridae Proteins; Tritium; Viral Envelope Proteins | 1985 |
Intracellular transport of asialoglycoproteins in rat hepatocytes. Evidence for two subpopulations of lysosomes.
Topics: Animals; Asialoglycoproteins; Cell Fractionation; Cellobiose; Cells, Cultured; Colchicine; Depression, Chemical; Leupeptins; Liver; Lysosomes; Male; Monensin; Orosomucoid; Rats; Rats, Inbred Strains; Tyramine | 1985 |
Trypsin-like enzyme from eggs of the ascidian (protochordate), Halocynthia roretzi. Purification, properties, and physiological role.
Topics: Animals; Fertilization; Isoelectric Point; Leupeptins; Molecular Weight; Ovum; Protease Inhibitors; Substrate Specificity; Trypsin; Urochordata | 1985 |
High-performance liquid chromatographic method for monitoring leupeptin in mouse serum and muscle by pre-column fluorescence derivatization with benzoin.
Topics: Animals; Benzoin; Chromatography, High Pressure Liquid; Leupeptins; Mice; Mice, Inbred C57BL; Muscles; Oligopeptides; Spectrometry, Fluorescence | 1985 |
Protein degradation in the lysosome.
Topics: Animals; Autolysis; Hydrogen-Ion Concentration; Leupeptins; Liver; Lysosomes; Male; Phagocytosis; Proteins; Rats; Subcellular Fractions | 1985 |
Quantitative assessment of the contribution of autophagy to intracellular protein breakdown.
Topics: Animals; Autolysis; Cathepsins; Cycloheximide; Cytoplasm; Drug Administration Schedule; Fasting; Homeostasis; Leupeptins; Liver; Lysosomes; Microtubules; Protein Conformation; Proteins; Rats | 1985 |
Evidence for membrane-associated calpain I in human erythrocytes. Detection by an immunoelectrophoretic blotting method using monospecific antibody.
Topics: Antibodies, Monoclonal; Calcium; Calcium-Binding Proteins; Calpain; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Erythrocyte Membrane; Humans; Immunoelectrophoresis; Immunoglobulin G; Leupeptins; Protease Inhibitors | 1984 |
Effects of protein-degradation inhibitors on the inactivation of tyrosine aminotransferase, tryptophan oxygenase and benzopyrene hydroxylase in isolated rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cell Separation; Cycloheximide; In Vitro Techniques; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leupeptins; Liver; Male; Methylamines; Oligopeptides; Rats; Rats, Inbred Strains; Tryptophan Oxygenase; Tyrosine Transaminase | 1982 |
Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin.
Topics: Acid Phosphatase; Aminopeptidases; Animals; Autophagy; Cathepsin D; Cathepsin H; Cathepsins; Centrifugation, Density Gradient; Cycloheximide; Cysteine Endopeptidases; Cytoplasm; Dexamethasone; Fructose-Bisphosphate Aldolase; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Male; Oligopeptides; Organoids; Phagocytosis; Rats; Rats, Inbred Strains; Tyrosine Transaminase; Vacuoles | 1983 |
The biochemistry of memory: a new and specific hypothesis.
Topics: Animals; Calcium; Calpain; Carrier Proteins; Cerebral Cortex; Endopeptidases; Glutamates; Glutamic Acid; Hippocampus; Humans; Learning; Leupeptins; Memory; Microfilament Proteins; Neuronal Plasticity; Rabbits; Rats; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Membranes; Telencephalon | 1984 |
Diacytosis of 125I-asialoorosomucoid by rat hepatocytes. A non-lysosomal pathway insensitive to inhibition by inhibitors of ligand degradation.
Topics: Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Cells, Cultured; Chloroquine; Colchicine; Cold Temperature; Endocytosis; Endosomes; Exocytosis; Kinetics; Leupeptins; Liver; Lysosomes; Monensin; Rats; Receptors, Immunologic | 1984 |
Comparative studies on the calcium paradox in cardiac muscle: the effect of temperature on the different phases.
Topics: Animals; Calcium; Leupeptins; Mice; Mice, Inbred BALB C; Microscopy, Electron; Myocardial Contraction; Myocardium; Perfusion; Rana temporaria; Temperature | 1984 |
Acid proteolytic activities in mouse liver and muscle tissues after treatment with protease inhibitor leupeptin.
Topics: Animals; Cathepsin B; Cathepsin C; Cathepsin D; Cathepsins; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Glucuronidase; Leupeptins; Liver; Male; Mice; Muscles; Oligopeptides; Peptide Hydrolases; Time Factors | 1984 |
Evidence for exchange of inhibitors which bind to the active site of trypsin. Displacement of one inhibitor with a competitive inhibitor.
Topics: Aprotinin; Binding Sites; Binding, Competitive; Kinetics; Leupeptins; Ovomucin; Protein Binding; Trypsin; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitors | 1981 |
Antiproteinase chemotherapy of acute experimental pancreatitis using the low molecular weight oligopeptide aldehyde leupeptin.
Topics: Acute Disease; Animals; Aprotinin; Chromatography, Gel; Infusions, Parenteral; Leupeptins; Male; Oligopeptides; Pancreatitis; Rats; Rats, Inbred Strains | 1982 |
Neurofilament accumulation induced in synapses by leupeptin.
Topics: Animals; Axonal Transport; Calpain; Cytoskeleton; Fishes; Leupeptins; Nerve Endings; Neuronal Plasticity; Oligopeptides; Protease Inhibitors; Synapses; Synaptic Transmission | 1983 |
Factors affecting the reproducibility of androgen receptor determinations in human prostate.
Topics: Aprotinin; Dihydrotestosterone; Estrenes; Humans; Leupeptins; Male; Methods; Metribolone; NADP; Prostate; Receptors, Androgen; Receptors, Steroid | 1983 |
Comparative studies on the role of calcium in triggering subcellular damage in cardiac muscle.
Topics: Animals; Caffeine; Calcimycin; Calcium; Dinitrophenols; Heart; Leupeptins; Mice; Mice, Inbred Strains; Mitochondria, Heart; Myocardial Contraction; Myocardium; Rana temporaria; Ruthenium Red; Subcellular Fractions | 1984 |
Leupeptin's effect on organ weight, RNA, DNA, and protein content after long bone fracture in the rat.
Topics: Animals; Body Weight; Diaphragm; DNA; Eating; Femoral Fractures; Leupeptins; Liver; Male; Oligopeptides; Organ Size; Proteins; Rats; Rats, Inbred Strains; RNA | 1984 |
125I-Insulin internalization by perfused rat liver: comparison of its subcellular distribution with that of a lysosomally targeted molecule, 125I-asialofetuin.
Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Fetuins; Insulin; Intracellular Membranes; Leupeptins; Liver; Lysosomes; Male; Perfusion; Rats; Rats, Inbred Strains; Subcellular Fractions | 1984 |
Receptor properties of corticosteroid binder IB.
Topics: Animals; Antipain; Cell Nucleus; Deoxyribonuclease I; Endodeoxyribonucleases; Kidney; Leupeptins; Liver; Male; Micrococcal Nuclease; Oligodeoxyribonucleotides; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Receptors, Steroid; Spermidine | 1982 |
Glycoprotein Ib in the Triton-insoluble (cytoskeletal) fraction of blood platelets.
Topics: Blood Platelets; Cytoskeleton; Edetic Acid; Glycoproteins; Humans; Immunoelectrophoresis, Two-Dimensional; Leupeptins; Membrane Proteins; Molecular Weight; Octoxynol; Platelet Membrane Glycoproteins; Polyethylene Glycols; Solubility; Thrombin | 1984 |
High-performance affinity chromatography of plasmin and plasminogen on a hydrophilic vinyl-polymer gel coupled with p-aminobenzamidine.
Topics: Amidines; Benzamidines; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Fibrinolysin; Leupeptins; Plasminogen; Spectrophotometry, Ultraviolet; Trypsin Inhibitors | 1984 |
Autolysis of calcium-activated neutral protease of chicken skeletal muscle.
Topics: Animals; Calcium; Calpain; Chickens; Edetic Acid; Endopeptidases; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Molecular Weight; Muscles; Peptide Hydrolases; Protease Inhibitors; Temperature | 1981 |
Calcium facilitates endogenous proteolysis of the EGF receptor-kinase.
Topics: Animals; Calcium; Carcinoma, Squamous Cell; Cell Line; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Humans; Leupeptins; Mice; Molecular Weight; Peptide Hydrolases; Phosphorylation; Protein Kinases; Receptors, Cell Surface | 1982 |
Proteolysis of the epidermal growth factor receptor by endogenous calcium-activated neutral protease from rat liver.
Topics: Animals; Calpain; Endopeptidases; ErbB Receptors; Leupeptins; Liver; Male; Molecular Weight; Phosphorylation; Rats; Rats, Inbred Strains; Receptors, Cell Surface | 1983 |
The effects of serine protease inhibitors on morphological differentiation of murine neuroblastoma cells (NB15).
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Antipain; Cell Differentiation; Cyclic AMP; Isoflurophate; Leupeptins; Mice; Neuroblastoma; Trypsin Inhibitor, Kunitz Soybean | 1984 |
Structural comparisons of wild-type and nuclear transport-defective simian virus 40 large tumor antigens.
Topics: Adenoviridae; Amino Acid Sequence; Antigens, Viral, Tumor; Biological Transport; Cell Nucleus; Hybridization, Genetic; Leupeptins; Methionine; Mutation; Octoxynol; Peptides; Phosphopeptides; Phosphorylation; Polyethylene Glycols; Simian virus 40; Viral Proteins | 1984 |
Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.
Topics: Animals; Cycloheximide; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Horseradish Peroxidase; In Vitro Techniques; Kinetics; Leupeptins; Ligands; Liver; Male; Microscopy, Electron; Rats; Receptors, Cell Surface; Subcellular Fractions | 1984 |
Leupeptin, a thiol proteinase inhibitor, causes a selective impairment of spatial maze performance in rats.
Topics: Animals; Avoidance Learning; Brain; Cysteine Endopeptidases; Discrimination Learning; Dose-Response Relationship, Drug; Leupeptins; Male; Mental Recall; Oligopeptides; Orientation; Protease Inhibitors; Rats; Rats, Inbred Strains; Space Perception; Synaptic Transmission | 1984 |
Antigen conformation determines processing requirements for T-cell activation.
Topics: Ammonium Chloride; Animals; Antigens; Chloroquine; Clone Cells; Leupeptins; Lymphocyte Activation; Lysosomes; Mice; Monensin; Myoglobin; Peptide Fragments; Protein Conformation; Protein Denaturation; Structure-Activity Relationship; T-Lymphocytes | 1984 |
Adhesion of cells to polystyrene surfaces.
Topics: Animals; Bacteriological Techniques; Cell Adhesion; Cricetinae; Culture Media; Cycloheximide; Kidney; Leupeptins; Oxidation-Reduction; Polystyrenes; Trypsin | 1983 |
Partial characterization of protease(s) in human breast cancer cytosols that can degrade estrogen and progesterone receptors selectively.
Topics: Breast Neoplasms; Cytosol; Estradiol; Female; Humans; Kinetics; Leupeptins; Molybdenum; Peptide Hydrolases; Receptors, Estradiol; Receptors, Estrogen; Receptors, Progesterone; Substrate Specificity; Uterus | 1984 |
Biosynthesis of intestinal microvillar proteins. Further characterization of the intracellular processing and transport.
Topics: alpha-Glucosidases; Aminopeptidases; Animals; Biological Transport; Glucosamine; Glucosidases; Glycoproteins; Intestinal Mucosa; Leupeptins; Microvilli; Molecular Weight; Multienzyme Complexes; Sucrase-Isomaltase Complex; Swine; Tunicamycin | 1984 |
Regulatory proteolysis during corticosteroid hormone action.
Topics: Adrenal Cortex Hormones; Animals; Humans; Kidney; Leupeptins; Liver; Peptide Hydrolases; Protein Conformation; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Trypsin Inhibitors | 1984 |
Purification and characterization of hemoglobin-hydrolyzing acidic thiol protease induced by leupeptin in rat liver.
Topics: Animals; Cysteine Endopeptidases; Endopeptidases; Enzyme Induction; Hemoglobins; Hydrolysis; Kinetics; Leupeptins; Liver; Male; Microscopy, Electron; Oligopeptides; Rats; Rats, Inbred Strains; Subcellular Fractions | 1984 |
Lysosomal function in the degradation of defective collagen in cultured lung fibroblasts.
Topics: Cells, Cultured; Collagen; Endopeptidases; Female; Fibroblasts; Humans; Leupeptins; Lung; Lysosomes; Pepstatins; Pregnancy; Procollagen; Tosyllysine Chloromethyl Ketone | 1984 |
Effects of the protease inhibitor leupeptin on proteolytic activities and regeneration of mouse skeletal muscles after exercise injuries.
Topics: Animals; Cathepsin B; Cathepsin D; Cathepsins; Glucuronidase; Leupeptins; Male; Mice; Muscles; Oligopeptides; Peptide Hydrolases; Physical Exertion; Regeneration; Stimulation, Chemical; Time Factors | 1984 |
Inhibition of in-vitro fertilization of hamster oocytes by a thiol proteinase inhibitor.
Topics: Animals; Antipain; Cricetinae; Culture Media; Cystatins; Cysteine Endopeptidases; Enzyme Inhibitors; Female; Fertilization in Vitro; Leupeptins; Male; Oocytes; Protease Inhibitors; Sperm Motility; Time Factors | 1984 |
Cytochemical demonstrations of protease in human peripheral blood cells by use of new alpha-naphthyl ester substrates.
Topics: Chymotrypsin; Histocytochemistry; Humans; Iodoacetates; Iodoacetic Acid; Isoflurophate; Leukocytes; Leupeptins; Lysine; Male; Naphthols; Neutrophils; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Substrate Specificity; Tyrosine | 1983 |
Inhibition of cell adhesion in Dictyostelium discoideum by tunicamycin is prevented by leupeptin.
Topics: Aspartic Acid Endopeptidases; Cell Adhesion; Dictyostelium; Edetic Acid; Endopeptidases; Glucosamine; Leucine; Leupeptins; Oligopeptides; Tunicamycin | 1983 |
Mechanism of autodegradation of cell-surface macromolecules shed by human melanoma cells.
Topics: Ammonium Chloride; Biological Transport; Cadaverine; Cell Line; Chloroquine; Coated Pits, Cell-Membrane; Colchicine; Cytochalasin B; Endocytosis; Humans; Leupeptins; Lysosomes; Melanoma; Membrane Proteins; Monensin; Neoplasm Proteins; Time Factors; Tunicamycin | 1984 |
An abnormality in intracellular protein degradation in fibroblasts from patients with I-cell disease.
Topics: Ammonium Chloride; Cytosol; Fibroblasts; Half-Life; Humans; Leupeptins; Lysosomes; Mucolipidoses; Pepstatins; Proteins | 1984 |
Effects of inhibitors of protein degradation on the rate of protein synthesis in Chinese hamster ovary cells.
Topics: Amino Acids; Animals; Cell Line; Chloroquine; Cricetinae; Cricetulus; Female; Kinetics; Leupeptins; Oligopeptides; Ovary; Protein Biosynthesis; Proteins | 1984 |
The proteinase inhibitors leupeptin, pepstatin A, and TLCK cause reduced collagen production in freshly isolated embryonic chick fibroblasts in suspension culture.
Topics: Amino Acid Chloromethyl Ketones; Animals; Chick Embryo; Collagen; Fibroblasts; In Vitro Techniques; Leupeptins; Oligopeptides; Pepstatins; Tendons; Tosyllysine Chloromethyl Ketone | 1984 |
Heterogeneity of free valine pools for protein synthesis on free and membrane-bound polysomes in rat liver.
Topics: Animals; Kinetics; Leupeptins; Liver; Molecular Weight; Polyribosomes; Protein Biosynthesis; Proteins; Rats; Rats, Inbred Strains; Tritium; Valine | 1984 |
Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain.
Topics: Animals; Brain; Chloroquine; Leupeptins; Lysosomes; Microscopy, Electron; Oligopeptides; Rats; Rats, Inbred Strains | 1984 |
Suppression of experimental allergic encephalomyelitis (EAE) with liposome-encapsulated protease inhibitor: therapy through the blood-brain barrier.
Topics: Animals; Blood-Brain Barrier; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Leupeptins; Liposomes; Oligopeptides; Phosphatidylcholines; Sulfoglycosphingolipids | 1984 |
Similar effects of various low-molecular-weight enzyme inhibitors on enzyme networks in dystrophic mice.
Topics: Alkaline Phosphatase; Aminopeptidases; Animals; Esterases; Forelimb; Glutamyl Aminopeptidase; Glycine; Hindlimb; Leucine; Leucyl Aminopeptidase; Leupeptins; Male; Mice; Mice, Mutant Strains; Molecular Weight; Muscles; Muscular Dystrophy, Animal; Oligopeptides; Spleen | 1984 |
Elevated ammonia release from dystrophic chicken muscle cell and fibroblast cultures.
Topics: Adenosine Deaminase; Ammonia; Animals; Cells, Cultured; Chick Embryo; Fibroblasts; Leupeptins; Muscular Dystrophy, Animal; Protein Denaturation | 1984 |
Interrelations between the maturation of a 100 kDa nucleolar protein and pre rRNA synthesis in CHO cells.
Topics: Animals; Cell Line; Cell Nucleolus; Cloning, Molecular; Cricetinae; Cricetulus; DNA; DNA, Ribosomal; Female; Leupeptins; Molecular Weight; Nucleic Acid Precursors; Nucleoproteins; Oligopeptides; Ovary; Plasmids; RNA Precursors; RNA, Ribosomal; Transcription, Genetic | 1984 |
The fate of homologous 125I-labelled immunoglobulin G within rat visceral yolk sacs incubated in vitro.
Topics: 2,4-Dinitrophenol; Ammonium Chloride; Animals; Dinitrophenols; Female; Immunoglobulin G; In Vitro Techniques; Iodine Radioisotopes; Leupeptins; Povidone; Pregnancy; Rats; Rotenone; Serum Albumin, Bovine; Yolk Sac | 1983 |
Binding and degradation of doubly radioiodinated luteinizing hormone by mouse Leydig cells.
Topics: Animals; Leupeptins; Leydig Cells; Luteinizing Hormone; Male; Mice; Testosterone; Time Factors | 1983 |
Inhibition of proteolysis in rat yolk sac as a cause of teratogenesis. Effects of leupeptin in vitro and in vivo.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Leucine; Leupeptins; Oligopeptides; Pinocytosis; Povidone; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Yolk Sac | 1983 |
Endocytosis of formaldehyde-denatured serum albumin by nonparenchymal liver cells in vitro.
Topics: Animals; Endocytosis; Formaldehyde; Leupeptins; Liver; Lysosomes; Monensin; Protein Conformation; Protein Denaturation; Rats; Serum Albumin; Structure-Activity Relationship | 1984 |
Uptake and degradation of 125I-labeled rat asialoorosomucoid by the perfused rat liver.
Topics: Animals; Asialoglycoproteins; Biological Transport; In Vitro Techniques; Iodine Radioisotopes; Leupeptins; Liver; Male; Orosomucoid; Perfusion; Rats; Rats, Inbred Strains | 1984 |
Inhibition of fusion of skeletal myoblasts by tunicamycin and its reversal by N-acetylglucosamine.
Topics: Acetylglucosamine; Animals; Cell Division; Cell Fusion; Cell Line; Cell Membrane; Glucosamine; Glycoproteins; Kinetics; Leupeptins; Membrane Proteins; Molecular Weight; Muscles; Rats; Tunicamycin | 1984 |
Inhibition of Leishmania amastigote growth by antipain and leupeptin.
Topics: Animals; Antipain; Antiprotozoal Agents; Leishmania; Leupeptins; Macrophages; Mice; Microbial Sensitivity Tests; Oligopeptides; Pentamidine | 1984 |
Role of thiols, pH and cathepsin D in the lysosomal catabolism of serum albumin.
Topics: Animals; Cathepsin D; Cathepsins; Cysteine; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Iodoacetamide; Kidney; Leupeptins; Liver; Lysosomes; Mice; Pepstatins; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Sulfhydryl Compounds | 1984 |
Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers.
Topics: 2,4-Dinitrophenol; Acrylamides; Animals; Chromatography, Gel; Dinitrophenols; Female; Kinetics; Leupeptins; Pinocytosis; Polymers; Rats; Tyrosine; Yolk Sac | 1984 |
Characterization of subfractions of autolysosomes isolated from rat liver after leupeptin treatment.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Intracellular Membranes; Leupeptins; Lipids; Liver; Lysosomes; Male; Membrane Proteins; Oligopeptides; Rats; Rats, Inbred Strains; Solubility | 1984 |
Degradation of proteins in rat liver mitochondrial outer membrane transplanted into different cell types. Evidence for alternative processing.
Topics: Ammonium Chloride; Animals; Cell Line; Cricetinae; Cycloheximide; Half-Life; Humans; Intracellular Membranes; Leucine; Leupeptins; Liver Neoplasms, Experimental; Membrane Proteins; Mice; Microscopy, Fluorescence; Mitochondria, Liver; Rats | 1984 |
Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores.
Topics: Amines; Ammonium Chloride; Animals; Antigens, Surface; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Humans; Ionophores; Isoantibodies; Kinetics; Leukemia, Experimental; Leupeptins; Mice; Monensin; Nigericin; Pepstatins; Protein Biosynthesis; Ricin | 1984 |
On the mechanisms of inhibition of insulin action by small-molecular-weight trypsin inhibitors.
Topics: Adipose Tissue; Animals; Benzamidines; Glucose; Guanidines; In Vitro Techniques; Insulin; Insulin Antagonists; Isoflurophate; Leupeptins; Molecular Weight; Rats; Tosylarginine Methyl Ester; Trypsin Inhibitors | 1982 |
Easily releasable myofilaments from skeletal and cardiac muscles maintained in vitro. Role in myofibrillar assembly and turnover.
Topics: Animals; Calcimycin; Cell Fractionation; Female; Leupeptins; Molecular Weight; Muscle Proteins; Muscles; Myocardium; Myofibrils; Myosins; Rats; Rats, Inbred Strains; Trypsin | 1981 |
Molecular defect in combined beta-galactosidase and neuraminidase deficiency in man.
Topics: beta-Galactosidase; Cells, Cultured; Enzyme Precursors; Fibroblasts; Humans; Lactose Intolerance; Leupeptins; Lysosomes; Molecular Weight; Neuraminidase | 1982 |
Degradation of [6-3H]- and [1-14C]glucosamine-labeled asialo-alpha 1-acid glycoprotein by the perfused rat liver.
Topics: Animals; Asialoglycoproteins; Biological Transport; Carbon Radioisotopes; Glucosamine; Kinetics; Leupeptins; Liver; Male; Orosomucoid; Perfusion; Rats; Rats, Inbred Strains; Tritium | 1983 |
Paradoxical effect of leupeptin in vivo on cathepsin B activity.
Topics: Animals; Cathepsin B; Cathepsins; Kidney; Kinetics; Leupeptins; Liver; Lysosomes; Male; Mice; Mice, Inbred DBA; Muscles; Myocardium; Oligopeptides | 1983 |
Ultrastructural studies on autolysosomes in rat hepatocytes after leupeptin treatment.
Topics: Acid Phosphatase; Animals; Autophagy; Leupeptins; Liver; Lysosomes; Male; Microbodies; Microscopy, Electron; Oligopeptides; Organoids; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Degradation of acetylcholine receptors in muscle cells: effect of leupeptin on turnover rate, intracellular pool sizes, and receptor properties.
Topics: Animals; Bungarotoxins; Cell Line; Centrifugation, Density Gradient; Leupeptins; Mice; Muscles; Oligopeptides; Receptors, Cholinergic | 1983 |
A comparison of lysosomal involvements in the degradation of normal and abnormal endogenous proteins of differing half-lives in MRC5 cells.
Topics: Amino Acids; Cell Line; Colchicine; DNA; Fibroblasts; Half-Life; Humans; Leupeptins; Lysosomes; Methylamines; Proteins; Vinblastine | 1983 |
Interaction of methotrexate poly(L-lysine) with transformed hepatic cells in culture.
Topics: Animals; Biological Transport; Cell Survival; Kinetics; Leucovorin; Leupeptins; Liver Neoplasms, Experimental; Methotrexate; Peptides; Polylysine; Rats | 1982 |
The effects of low temperature and chloroquine on 125I-insulin degradation by the perfused rat liver.
Topics: Animals; Biological Transport; Chloroquine; Cold Temperature; Insulin; Kinetics; Leupeptins; Liver; Perfusion; Rats; Subcellular Fractions | 1981 |
The degradation of endogenous and exogenous proteins in cultured smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Cattle; Cell Line; Chloroquine; Chymotrypsin; Embryo, Mammalian; Humans; Kinetics; Leupeptins; Lipoproteins, LDL; Lysosomes; Muscle, Smooth, Vascular; Oligopeptides; Proteins | 1982 |
Intracellular transport and degradation of 125I-Labelled denatured serum albumin in isolated nonparenchymal rat liver cells.
Topics: Animals; Biological Transport, Active; In Vitro Techniques; Leupeptins; Liver; Lysosomes; Male; Protein Denaturation; Rats; Rats, Inbred Strains; Serum Albumin; Subcellular Fractions | 1982 |
The regulation of proteolysis in normal fibroblasts as they approach confluence. Evidence for the participation of the lysosomal system.
Topics: Ammonium Chloride; Animals; Cells, Cultured; Diazomethane; Fibroblasts; Humans; Leupeptins; Lysosomes; Mice; Pepstatins; Proteins | 1982 |
Purification and properties of an enzyme reducing leupeptin acid to leupeptin.
Topics: Adenosine Triphosphate; Aldehyde Oxidoreductases; Cell Membrane; Drug Stability; Leupeptins; Molecular Weight; NADP; Oligopeptides; Oxidation-Reduction; Peptide Synthases; Streptomyces | 1981 |
Induced cell injury and cell death as a cause of congenital malformations in rats.
Topics: Abnormalities, Drug-Induced; Animals; Cathepsins; Cell Survival; Congenital Abnormalities; Dose-Response Relationship, Drug; Endocytosis; Female; Kidney; Leupeptins; Microscopy, Electron; Oligopeptides; Placenta; Pregnancy; Rats; Trypan Blue; Yolk Sac | 1981 |
Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases.
Topics: Animals; Antipain; Aprotinin; Blotting, Western; CHO Cells; Cricetinae; Endopeptidases; Enzyme-Linked Immunosorbent Assay; Hepatocyte Growth Factor; Humans; Leupeptins; Liver Failure, Acute; Macromolecular Substances; Protease Inhibitors; Protein Precursors; Recombinant Proteins; Transfection | 1995 |
Degradation of cystathionine gamma-lyase in rat liver lysosomes: effect of leupeptin treatment.
Topics: Animals; Cystathionine gamma-Lyase; Immunoblotting; Leupeptins; Liver; Lysosomes; Molecular Weight; Rats; Reference Values | 1995 |
Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagine on vacuole distributions.
Topics: Animals; Antigens, CD; Asparagine; Autophagy; Biomarkers; Carbonic Anhydrases; Cattle; Endocytosis; Gold Colloid; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomal Membrane Proteins; Lysosomal-Associated Membrane Protein 1; Lysosomes; Male; Membrane Glycoproteins; Microtubules; Protease Inhibitors; Rats; Rats, Wistar; Serum Albumin, Bovine; Superoxide Dismutase; Vacuoles; Vinblastine | 1995 |
Proteolytic conversion of single chain precursor macrophage-stimulating protein to a biologically active heterodimer by contact enzymes of the coagulation cascade.
Topics: Animals; Aprotinin; Blood Coagulation Factors; Cells, Cultured; Chemotaxis; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; Enzyme-Linked Immunosorbent Assay; Factor XIa; Factor XIIa; Growth Substances; Hepatocyte Growth Factor; Humans; Kallikreins; Kinetics; Leupeptins; Macromolecular Substances; Macrophages; Mice; Molecular Weight; Protein Precursors; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Recombinant Proteins; Serine Proteinase Inhibitors; Transfection | 1994 |
Aging and proteolysis of oxidized proteins.
Topics: Aging; Animals; Aprotinin; Endopeptidases; Enzyme Stability; Hot Temperature; Houseflies; Hydrogen-Ion Concentration; Leupeptins; Male; Oxidation-Reduction; Protease Inhibitors; Proteins; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine | 1994 |
Identification of targeting proteinase for rat alpha 1-macroglobulin in vivo. Mast-cell tryptase is a major component of the alpha 1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes.
Topics: alpha-Macroglobulins; Amino Acid Sequence; Animals; Chymases; Endocytosis; Hydrogen-Ion Concentration; Leupeptins; Liver; Lysosomes; Male; Mast Cells; Molecular Sequence Data; Protease Inhibitors; Rats; Rats, Wistar; Serine Endopeptidases; Substrate Specificity; Tryptases | 1994 |
In vitro stability of endogenous parathyroid hormone-related protein in blood and plasma.
Topics: Anticoagulants; Aprotinin; Blood Specimen Collection; Edetic Acid; Heparin; Humans; Hypercalcemia; Immunoradiometric Assay; In Vitro Techniques; Infant; Leupeptins; Neoplasms; Parathyroid Hormone-Related Protein; Pepstatins; Peptide Fragments; Peptides; Protease Inhibitors; Temperature | 1994 |
The role of proteases in stratum corneum: involvement in stratum corneum desquamation.
Topics: Antipain; Aprotinin; Detergents; Endopeptidases; Epidermis; Ethylmaleimide; Humans; Leucine; Leupeptins; Oligopeptides; Pepstatins; Protease Inhibitors; Sunburn | 1994 |
Human chorionic gonadotropin beta-subunit nicking enzymes in pregnancy and cancer patient serum.
Topics: Amino Acid Sequence; Blotting, Western; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Chromatography, Gel; Disulfides; Endopeptidases; Female; Humans; Leupeptins; Macromolecular Substances; Male; Metalloendopeptidases; Molecular Sequence Data; Neoplasms; Peptide Fragments; Phenanthrolines; Pregnancy | 1994 |
Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells.
Topics: Amino Acid Sequence; Ammonium Chloride; Animals; Arsenicals; Cell Line, Transformed; Chloroquine; Colchicine; Endocytosis; Epithelium; Hypertonic Solutions; Immune Sera; Immunohistochemistry; Kinetics; Leupeptins; Microscopy, Fluorescence; Molecular Sequence Data; Monensin; Peptides; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Time Factors; Transfection | 1994 |
How MHC class II molecules reach the endocytic pathway.
Topics: Anti-Bacterial Agents; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Biological Transport; Cell Compartmentation; Cell Membrane; Cells, Cultured; Cold Temperature; Endocytosis; Endopeptidases; Epitopes; Fluorescent Antibody Technique; Histocompatibility Antigens Class II; Hot Temperature; Humans; Leupeptins; Macrolides; Microscopy, Confocal; Microscopy, Immunoelectron; Models, Immunological; Neuraminidase; Sodium Dodecyl Sulfate | 1995 |
Unique specificity of in vitro inhibition of mosquito midgut trypsin-like activity correlates with in vivo inhibition of malaria parasite infectivity.
Topics: Aedes; Animals; Aprotinin; Chickens; Female; Insect Vectors; Leupeptins; Plasmodium gallinaceum; Trypsin; Trypsin Inhibitors | 1995 |
Formation of autophagosomes during degradation of excess peroxisomes induced by di-(2-ethylhexyl)-phthalate treatment. III. Fusion of early autophagosomes with lysosomal compartments.
Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Autophagy; Cell Compartmentation; Centrifugation, Density Gradient; Diethylhexyl Phthalate; Fetuins; Horseradish Peroxidase; Leupeptins; Lysosomes; Male; Microbodies; Rats; Rats, Wistar | 1995 |
Antigen-presenting cell lines internalize peptide antigens via fluid-phase endocytosis.
Topics: Animals; Antigen-Presenting Cells; Antigens; Aprotinin; Cell Line; Chromatography, Gel; Leupeptins; Mice; Peptides; Pinocytosis | 1995 |
Heparin-binding vitronectin up-regulates latent TGF-beta production by bovine aortic endothelial cells.
Topics: Animals; Antibodies; Aorta; Aprotinin; Blotting, Western; Cattle; Cell Line; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Endothelium, Vascular; Extracellular Matrix Proteins; Glycoproteins; Heparin; Kinetics; Leupeptins; Membrane Glycoproteins; Thrombospondins; Transforming Growth Factor beta; Vitronectin | 1995 |
A labile hyperphosphorylated c-Fos protein is induced in mouse fibroblast cells treated with a combination of phorbol ester and anti-tumor promoter curcumin.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antineoplastic Agents; Base Sequence; Carcinogens; Curcumin; Gene Expression; Genes, fos; Genes, jun; In Vitro Techniques; Leupeptins; Mice; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins c-fos; RNA, Messenger; Tetradecanoylphorbol Acetate | 1995 |
The intracellular transport of MHC class II molecules in the absence of HLA-DM.
Topics: Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Biological Transport; Cell Line; Histocompatibility Antigens Class II; HLA-D Antigens; HLA-DR3 Antigen; Humans; Leupeptins; Lymphocyte Activation; Protease Inhibitors; Subcellular Fractions | 1995 |
Inhibitory effect of leupeptin on the intracellular maturation of lysosomal cathepsin L in primary cultures of rat hepatocytes.
Topics: Animals; Cathepsin L; Cathepsins; Cells, Cultured; Cysteine Endopeptidases; Endopeptidases; Kinetics; Leupeptins; Liver; Lysosomes; Male; Molecular Weight; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Subcellular Fractions; Sulfur Radioisotopes | 1995 |
T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.
Topics: Alleles; Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Binding Sites; Epitopes; Glycine; Histocompatibility Antigens Class II; Humans; Hybrid Cells; Leupeptins; Lysine; Macromolecular Substances; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Conformation; Rats; Receptors, Antigen, T-Cell; Sequence Alignment; Structure-Activity Relationship; T-Lymphocytes; Transfection | 1995 |
Cytosolic Ca2+ elevation and calpain inhibitors in HgCl2 injury to rat kidney proximal tubule epithelial cells.
Topics: Animals; Antipain; Calcium; Calpain; Cell Survival; Cells, Cultured; Cytoplasm; Cytosol; Kidney Tubules, Proximal; Leupeptins; Male; Mercuric Chloride; Microscopy, Electron; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Rats | 1994 |
Protection by lysosomal hydrolase inhibitors against cytotoxicity of 2-chloroethylethyl sulfide.
Topics: Alkylation; Animals; Cell Survival; Cells, Cultured; Drug Interactions; Gentamicins; Kanamycin; Leupeptins; Lysosomes; Mice; Mice, Inbred ICR; Mustard Gas; Oligopeptides; Pepstatins; Phospholipases; Protease Inhibitors; Spleen; Streptomycin; Structure-Activity Relationship; T-Lymphocytes | 1995 |
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.
Topics: Animals; Atrophy; B-Lymphocytes; Cathepsin D; Chimera; Fibroblasts; Gene Targeting; Ileum; Intestinal Mucosa; Leupeptins; Lysosomes; Male; Mice; Mice, Inbred C57BL; Pepstatins; RNA, Messenger; Specific Pathogen-Free Organisms; Spleen; T-Lymphocytes; Thymus Gland | 1995 |
Kinetic study on the production and degradation of leupeptin in Streptomyces exfoliatus SMF13.
Topics: Cell Division; Culture Media; Glucose; Kinetics; Leupeptins; Phosphates; Serine Endopeptidases; Streptomyces | 1995 |
Peptidase modulation of vasoactive intestinal peptide pulmonary relaxation in tracheal superfused guinea pig lungs.
Topics: Animals; Aprotinin; Captopril; Dose-Response Relationship, Drug; Endopeptidases; Guinea Pigs; Leucine; Leupeptins; Lung; Male; Muscle Relaxation; Muscle, Smooth; Perfusion; Protease Inhibitors; Time Factors; Trachea; Trypsin Inhibitors; Vasoactive Intestinal Peptide | 1993 |
Protective effect of the protease inhibitor leupeptin against myocardial stunning.
Topics: Animals; Calpain; Enzyme Activation; Guinea Pigs; Hemodynamics; In Vitro Techniques; Leupeptins; Male; Myocardial Reperfusion Injury; Protease Inhibitors; Reference Values | 1993 |
Processing of endogenously synthesized hen egg-white lysozyme retained in the endoplasmic reticulum or in secretory form gives rise to a similar but not identical set of epitopes recognized by class II-restricted T cells.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chickens; Egg Proteins; Endoplasmic Reticulum; Epitopes; Histocompatibility Antigens Class II; Leupeptins; Mice; Molecular Sequence Data; Muramidase; Peptide Fragments; T-Lymphocytes; Transfection | 1993 |
Calpain-mediated regulation of AMPA receptors in adult rat brain.
Topics: Animals; Brain; Calcium; Calpain; Glycoproteins; Immunohistochemistry; Leupeptins; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Tissue Distribution | 1994 |
Excystment of Paragonimus westermani metacercariae by endogenous cysteine protease.
Topics: Animals; Chromatography, Ion Exchange; Collagen; Coumarins; Cysteine Endopeptidases; Dipeptides; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Fibronectins; Hydrogen-Ion Concentration; Iodoacetamide; Leucine; Leupeptins; Myosins; Oligopeptides; Pancreatic Elastase; Paragonimus; Temperature; Trypsin | 1995 |
Endogenous, Ca(2+)-dependent cysteine-protease cleaves specifically the ryanodine receptor/Ca2+ release channel in skeletal muscle.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Calcium; Calcium Channels; Calpain; Cysteine; Dithiothreitol; Iodoacetamide; Leupeptins; Magnesium; Mercaptoethanol; Mercuric Chloride; Molecular Sequence Data; Molecular Weight; Muscle Proteins; Muscle, Skeletal; Rabbits; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sodium Chloride; Substrate Specificity | 1994 |
Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Disease Models, Animal; Injections, Intraventricular; Leupeptins; Male; Models, Neurological; Nerve Degeneration; Neurofibrillary Tangles; Parietal Lobe; Rats; Rats, Wistar | 1995 |
Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Biological Transport; Endosomes; Histocompatibility Antigens Class II; Leupeptins; Mice; Protein Conformation; Sodium Dodecyl Sulfate | 1995 |
A protease-dependent TCR-induced death pathway in mature lymphocytes.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Calpain; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Cell Line; Cytotoxicity, Immunologic; Endopeptidases; Leupeptins; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Protease Inhibitors; Receptors, Antigen, T-Cell; T-Lymphocytes; Thymus Gland | 1995 |
Thiol-protease inhibitors selectively inhibit presentation of antigen incorporated through B cell antigen receptors.
Topics: Antigen Presentation; Antigens; Antipain; Cysteine Proteinase Inhibitors; Immunoglobulin M; Leupeptins; Major Histocompatibility Complex; Pinocytosis; Receptors, Antigen, B-Cell; Tumor Cells, Cultured | 1995 |
Role of calcium-activated neutral protease (calpain) in cell death in cultured neonatal rat cardiomyocytes during metabolic inhibition.
Topics: Animals; Animals, Newborn; Calcium; Calpain; Cell Death; Cells, Cultured; Chromatography, Affinity; Chromatography, Ion Exchange; Cysteine Proteinase Inhibitors; Enzyme Activation; Leucine; Leupeptins; Myocardium; Protease Inhibitors; Rats; Rats, Wistar | 1995 |
Physiological roles of leupeptin and extracellular proteases in mycelium development of Streptomyces exfoliatus SMF13.
Topics: Amino Acid Sequence; Endopeptidases; Extracellular Space; Glucose; Leupeptins; Metalloendopeptidases; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Serine Endopeptidases; Streptomyces; Substrate Specificity; Trypsin | 1995 |
Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases.
Topics: ADP Ribose Transferases; Amino Acid Sequence; Animals; Antigens, Bacterial; Bacterial Toxins; Cathepsin B; CHO Cells; Cricetinae; Diphtheria Toxin; Dose-Response Relationship, Drug; Endopeptidases; Exotoxins; Furin; Leupeptins; Molecular Sequence Data; Peptide Fragments; Pseudomonas aeruginosa Exotoxin A; Substrate Specificity; Subtilisins; Virulence Factors | 1995 |
Rat myoblast fusion requires exteriorized m-calpain activity.
Topics: Animals; Biological Assay; Calcium-Binding Proteins; Calpain; Cell Fusion; Cells, Cultured; Culture Media; Immunoglobulin G; Immunohistochemistry; Kinetics; Leupeptins; Muscle Fibers, Skeletal; Rats; Rats, Wistar | 1994 |
Potentially amyloidogenic fragment of 50 kDa and intracellular processing of amyloid precursor protein in cells cultured under leupeptin.
Topics: Amyloid; Amyloidosis; Blotting, Western; Cell Line; Centrifugation, Density Gradient; Humans; Immunologic Techniques; Intracellular Membranes; Leupeptins; Molecular Weight; Peptide Fragments; Prion Proteins; Prions; Protein Precursors; Subcellular Fractions | 1994 |
Acquisition of peptides by MHC class II polypeptides in the absence of the invariant chain.
Topics: Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Differentiation, B-Lymphocyte; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Leupeptins; Molecular Sequence Data; Peptides; Precipitin Tests; Protein Binding; Rats; Sodium Dodecyl Sulfate; Transfection; Tumor Cells, Cultured | 1995 |
Modulation of lipoxidase activity by urokinase-type plasminogen activator.
Topics: Amino Acid Sequence; Fatty Acids, Essential; Humans; Kidney; Leupeptins; Lipid Peroxidation; Lipoxygenase; Lipoxygenase Inhibitors; Molecular Sequence Data; Neoplasms; Plant Proteins; Urokinase-Type Plasminogen Activator | 1994 |
In vivo stimulation of I kappa B phosphorylation is not sufficient to activate NF-kappa B.
Topics: Amino Acid Sequence; Cell Line; Cell Nucleus; Cytosol; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Humans; I-kappa B Proteins; Immunoblotting; Kinetics; Leupeptins; Macromolecular Substances; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Oligopeptides; Phosphorylation; Transcription Factor RelA; Tumor Cells, Cultured | 1995 |
Branched-chain-amino-acid-preferring peptidase activity of the lobster multicatalytic proteinase (proteasome) and the degradation of myofibrillar proteins.
Topics: Amino Acids, Branched-Chain; Animals; Caseins; Cations; Endopeptidases; Hot Temperature; Leupeptins; Multienzyme Complexes; Muscle Proteins; Muscles; Myofibrils; Nephropidae; Oligopeptides; Peptide Fragments; Protease Inhibitors; Substrate Specificity; Troponin | 1995 |
Degradation of proteasomes by lysosomes in rat liver.
Topics: Animals; Cysteine Endopeptidases; Fasting; Half-Life; In Vitro Techniques; Leupeptins; Liver; Lysosomes; Male; Microscopy, Immunoelectron; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Wistar | 1995 |
Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites.
Topics: Animals; Antimalarials; Chymotrypsin; Coumarins; Cysteine Proteinase Inhibitors; Dipeptides; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Fluorescent Dyes; Globins; Humans; Hydrolysis; Leucine; Leupeptins; Oligopeptides; Pepstatins; Plasmodium falciparum; Vacuoles | 1995 |
Trichomonas vaginalis: amoeboid and flagellated forms synthesize similar proteinases.
Topics: Animals; Caseins; Culture Media; Cysteine Proteinase Inhibitors; Diazomethane; Endopeptidases; Leucine; Leupeptins; Lipoproteins; Trichomonas vaginalis | 1995 |
Neuromuscular contacts of expanded motor units in rat soleus muscles are rescued by leupeptin.
Topics: Amino Acid Sequence; Animals; Bungarotoxins; Denervation; Leupeptins; Molecular Sequence Data; Motor Neurons; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Neuromuscular Junction; Rats; Rats, Wistar; Silicone Elastomers | 1994 |
Peptide-antibody conjugates for tumour therapy: a MHC-class-II-restricted tetanus toxin peptide coupled to an anti-Ig light chain antibody can induce cytotoxic lysis of a human B-cell lymphoma by specific CD4 T cells.
Topics: Amino Acid Sequence; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; CD4-Positive T-Lymphocytes; Chloroquine; Histocompatibility Antigens Class II; Humans; Immunoglobulin Light Chains; Immunotoxins; Leupeptins; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Peptides; Tetanus Toxin | 1994 |
Increased activities of cathepsin B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of cysteine proteinases inhibitors.
Topics: Animals; Bone Resorption; Cathepsin B; Cells, Cultured; Culture Techniques; Cycloheximide; Fibroblasts; Hydrolases; Leupeptins; Mice; Parathyroid Hormone; Protein Biosynthesis; Proteins; Rats; Rats, Wistar; Skull; Time Factors | 1994 |
Inhibition of procollagen I degradation by colligin: a collagen-binding serpin.
Topics: Amino Acid Sequence; Animals; Biological Transport; Brefeldin A; Carrier Proteins; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Fibroblasts; Fibronectins; Glycoproteins; Humans; Hydrogen-Ion Concentration; Leupeptins; Microsomes, Liver; Molecular Sequence Data; Procollagen; Protease Inhibitors; Rats; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1994 |
Complement-mediated permeabilization of platelets by monoclonal antibodies to CD9: inhibition by leupeptin, and effects on the GP Ib-actin-binding protein system.
Topics: Actins; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Blood Platelets; Cell Membrane Permeability; Complement Inactivator Proteins; Digitonin; Humans; Leupeptins; Membrane Glycoproteins; Molecular Sequence Data; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Binding; Tetraspanin 29 | 1994 |
beta-Amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin.
Topics: Amyloid beta-Protein Precursor; Animals; Antibodies, Monoclonal; Axons; Blotting, Western; Brain; Cytoplasmic Granules; Dendrites; Female; Immunohistochemistry; Injections, Intraventricular; Leupeptins; Lysosomes; Neurons; Peptide Fragments; Rats; Rats, Wistar | 1994 |
Anti-ubiquitin immunoreactivity associates with pyramidal cell death induced by intraventricular infusion of leupeptin in rat hippocampus.
Topics: Animals; Cell Death; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Learning; Leupeptins; Male; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Ubiquitins | 1994 |
Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes.
Topics: Acids; Ammonium Chloride; Animals; Chloroquine; Dose-Response Relationship, Drug; Endocytosis; Flagella; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Intracellular Membranes; Leupeptins; Lipoproteins, HDL; Microscopy, Immunoelectron; Models, Biological; Monensin; Organelles; Protein Binding; Trypanosoma brucei brucei | 1994 |
Impact of lipofuscin on the retinal pigment epithelium: electroretinographic evaluation of a protease inhibition model.
Topics: Animals; Dark Adaptation; Disease Models, Animal; Electroretinography; Female; Injections; Leupeptins; Lipofuscin; Pigment Epithelium of Eye; Rats; Retina; Vitreous Body | 1994 |
Transcytosis and processing of intrinsic factor-cobalamin in Caco-2 cells.
Topics: Biological Transport; Cell Line; Cell Polarity; Cytoplasm; Endocytosis; Humans; Intestinal Mucosa; Intrinsic Factor; Leupeptins; Vitamin B 12 | 1994 |
Effects of exogenous protease effectors on beef tenderness development and myofibrillar degradation and solubility.
Topics: Animals; Calcimycin; Calcium; Calpain; Cathepsins; Cattle; Cysteine Proteinase Inhibitors; Diazomethane; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Glycoproteins; Leucine; Leupeptins; Male; Meat; Muscle Proteins; Muscles; Octoxynol; Pepstatins; Phenylmethylsulfonyl Fluoride; Postmortem Changes; Solubility | 1994 |
Leupeptin inhibits phospholipases D and C activation in rat hepatocytes.
Topics: Animals; Cell Membrane; Enzyme Activation; Glycerophospholipids; Guanosine 5'-O-(3-Thiotriphosphate); Leupeptins; Liver; Male; Phosphatidic Acids; Phospholipase D; Rats; Rats, Sprague-Dawley; Type C Phospholipases | 1994 |
Inhibition of peptide binding to DR molecules by a leupeptin-induced invariant chain fragment.
Topics: Amino Acid Sequence; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Line, Transformed; Histocompatibility Antigens Class II; HLA-DR Antigens; Leupeptins; Molecular Sequence Data; Particle Size; Peptide Fragments; Protein Binding | 1994 |
Cleavage of the epidermal growth factor receptor by a membrane-bound leupeptin-sensitive protease active in nonionic detergent lysates of senescent but not young human diploid fibroblasts.
Topics: Cell Line; Cell Membrane; Cellular Senescence; Detergents; Diploidy; Endopeptidases; ErbB Receptors; Fibroblasts; Humans; Intracellular Membranes; Leupeptins; Ligands; Phosphorylation; Protease Inhibitors; Protein Processing, Post-Translational; Solvents; Stimulation, Chemical; Trypsin | 1994 |
Evidence that acrosin activity is important for the development of fusibility of mammalian spermatozoa with the oolemma: inhibitor studies using the golden hamster.
Topics: Acrosin; Acrosome; Animals; Benzamidines; Cell Membrane; Cricetinae; Female; In Vitro Techniques; Leupeptins; Male; Membrane Fusion; Mesocricetus; Microscopy, Electron; Oocytes; Protease Inhibitors; Sperm-Ovum Interactions; Spermatozoa; Trypsin | 1993 |
Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts.
Topics: Animals; Cells, Cultured; Cysteine Proteinase Inhibitors; Fibroblasts; Gentamicins; Leucine; Leupeptins; Lysosomes; Phospholipids; Rats | 1994 |
Hepatectomy impairs hepatic processing of somatostatin-14.
Topics: Animals; Biological Transport; Chloroquine; Colchicine; Hepatectomy; Iodine Radioisotopes; Leupeptins; Liver; Liver Regeneration; Male; Rats; Rats, Sprague-Dawley; Somatostatin; Vinblastine | 1993 |
Internalization and intracellular processing of an anti-B-cell lymphoma monoclonal antibody, LL2.
Topics: 4-Chloro-7-nitrobenzofurazan; Ammonium Chloride; Antibodies, Monoclonal; Burkitt Lymphoma; Ceramides; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Golgi Apparatus; Humans; Immunoglobulin Fab Fragments; Kinetics; Leupeptins; Lymphoma, B-Cell; Lysosomes; Microscopy, Fluorescence; Tumor Cells, Cultured | 1994 |
Regulation of pathways within cultured epithelial cells for the transcytosis of a basal membrane-bound peroxidase-polylysine conjugate.
Topics: Animals; Biological Transport; Brefeldin A; Cell Polarity; Cyclopentanes; Dose-Response Relationship, Drug; Endocytosis; Epithelium; Horseradish Peroxidase; Leupeptins; Models, Biological; Polylysine; Protease Inhibitors; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
pH-dependent binding constants for the inhibition of thrombin by transition state analogs.
Topics: Amino Acid Sequence; Animals; Antithrombins; Arsenicals; Boronic Acids; Carboxylic Acids; Cattle; Dipeptides; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Molecular Sequence Data; Peptides; Piperidines; Thrombin | 1993 |
Pharmacological interference with tissue hypercatabolism in tumour-bearing rats.
Topics: Adrenalectomy; Animals; Aspirin; Blood Glucose; Body Weight; Cachexia; Cathepsin D; Cholesterol; Endopeptidases; Hormones; Insulin; Leupeptins; Male; Medroxyprogesterone Acetate; Muscle Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Wistar; Triglycerides | 1994 |
Protein degradation in kidney proximal tubule cell monolayers.
Topics: Ammonium Chloride; Animals; Cells, Cultured; Half-Life; Kidney Tubules, Proximal; Leupeptins; Proteins; Rats; Tritium | 1994 |
Separation of lysosomes and autophagosomes by means of glycyl-phenylalanine-naphthylamide, a lysosome-disrupting cathepsin-C substrate.
Topics: Animals; Autophagy; Cathepsin C; Cell Fractionation; Centrifugation; Centrifugation, Density Gradient; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Male; Methionine; Phagosomes; Rats; Rats, Wistar; Vinblastine | 1994 |
Differential phosphorylation in normal and leukemic granulocytes in response to phorbol 12-myristate 13-acetate.
Topics: Autoradiography; Electrophoresis, Gel, Two-Dimensional; Granulocytes; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leupeptins; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Tetradecanoylphorbol Acetate | 1994 |
Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture.
Topics: Animals; Blood; Culture Techniques; Embryo, Mammalian; Extremities; Female; Insulin; Insulin-Like Growth Factor II; Leucine; Leupeptins; Male; Methylamines; Mice; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sucrose; Vitamin A; Yolk Sac | 1994 |
Purification and characterization of the 1,200-kDa subfragment of connectin filaments produced by 0.1 mM calcium ions.
Topics: Actinin; Animals; Calcium Chloride; Carrier Proteins; Chickens; Chromatography, Gel; Connectin; Electrophoresis, Polyacrylamide Gel; Leupeptins; Microscopy, Fluorescence; Molecular Weight; Muscle Proteins; Myofibrils; Peptide Fragments; Protein Binding; Protein Kinases | 1994 |
Degradation of rat C-reactive protein by macrophages.
Topics: Animals; Biological Transport; C-Reactive Protein; Cations, Divalent; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Edetic Acid; Immunoglobulin G; Leupeptins; Macrophages, Peritoneal; Peptides; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Formation of autophagosomes during degradation of excess peroxisomes induced by administration of dioctyl phthalate.
Topics: Animals; Autophagy; Diethylhexyl Phthalate; Histocytochemistry; Leupeptins; Liver; Male; Microbodies; Microinjections; Rats; Rats, Wistar; Vacuoles | 1993 |
Polypeptide import and degradation by isolated lysosomes.
Topics: Amino Acid Sequence; Biological Transport; Cell Line; Heat-Shock Proteins; Humans; In Vitro Techniques; Leupeptins; Lysosomes; Molecular Sequence Data; Peptide Fragments; Peptides; Ribonuclease, Pancreatic; Ribonucleases; Structure-Activity Relationship | 1993 |
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
Topics: Amino Acid Sequence; Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Brefeldin A; Cell Line; Colchicine; Cyclopentanes; Golgi Apparatus; Humans; Kidney; Leupeptins; Lysosomes; Molecular Sequence Data; Monensin; Nocodazole; Protein Processing, Post-Translational; Transfection | 1993 |
Routes of excretion of neuronal lysosomal dense bodies after ventricular infusion of leupeptin in the rat: a study using ubiquitin and PGP 9.5 immunocytochemistry.
Topics: Animals; Cerebral Ventricles; Female; Immunohistochemistry; Infusions, Parenteral; Leupeptins; Lysosomes; Microscopy, Electron; Neurons; Rats; Rats, Wistar; Thiolester Hydrolases; Ubiquitin Thiolesterase; Ubiquitins | 1993 |
Release of DR molecules from complexes with invariant chain through the formation of a C-terminal 25 kDa invariant chain fragment.
Topics: Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Compartmentation; Cell Line, Transformed; Cells, Cultured; Chromobox Protein Homolog 5; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Golgi Apparatus; Herpesvirus 4, Human; Hexosaminidases; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Leupeptins; Lysosomes; Peptide Fragments; Protein Binding; Protein Conformation; Tetanus Toxin | 1993 |
Effect of high hydrostatic pressure on the conversion of alpha-connectin to beta-connectin.
Topics: Animals; Antibodies, Monoclonal; Calcium; Calpain; Connectin; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Hydrostatic Pressure; Leucine; Leupeptins; Molecular Weight; Muscle Proteins; Muscles; Protein Kinases; Rabbits | 1993 |
Stimulation of transcytosis of the polymeric immunoglobulin receptor by dimeric IgA.
Topics: Animals; Biological Transport; Cell Line; Cell Polarity; Dogs; Epithelium; Immunoglobulin A; Immunoglobulin Fab Fragments; Leupeptins; Mutagenesis, Site-Directed; Phosphoserine; Receptors, Immunologic; Secretory Component; Structure-Activity Relationship; Transferrin | 1994 |
Phorbol 12-myristate 13-acetate-stimulated phosphorylation of erythrocyte membrane skeletal proteins is blocked by calpain inhibitors: possible role of protein kinase M.
Topics: Amino Acid Sequence; Blood Proteins; Calpain; Down-Regulation; Erythrocyte Membrane; Glycoproteins; Humans; In Vitro Techniques; Leupeptins; Membrane Proteins; Molecular Sequence Data; Phosphorylation; Protease Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate | 1993 |
Kinetic studies on phagocytosis and lysosomal digestion of rod outer segments by human retinal pigment epithelial cells in vitro.
Topics: alpha-Mannosidase; Animals; Aspartic Acid Endopeptidases; Cattle; Cell Membrane; Cells, Cultured; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leupeptins; Lysosomes; Mannosidases; Microscopy, Electron; Microscopy, Electron, Scanning; Pepstatins; Phagocytosis; Pigment Epithelium of Eye; Rod Cell Outer Segment; Swainsonine; Zinc | 1994 |
Substratum acidification and proteinase activation by murine B16F10 melanoma cultures.
Topics: Animals; Cathepsin B; Cell Line; Endopeptidases; Enzyme Activation; Fluoresceins; Gels; Hydrogen-Ion Concentration; Leupeptins; Mice; Serum Albumin, Bovine; Tumor Cells, Cultured | 1993 |
Dual effect of thrombin on voltage-dependent Ca2+ channels of portal vein smooth muscle cells.
Topics: Animals; Calcium Channels; GTP-Binding Proteins; Guanosine Diphosphate; Hirudins; In Vitro Techniques; Isradipine; Leupeptins; Membrane Potentials; Muscle, Smooth, Vascular; Portal Vein; Rats; Rats, Wistar; Thionucleotides; Thrombin; Vasoconstriction | 1993 |
Calcium-induced degradation of the inositol (1,4,5)-trisphosphate receptor/Ca(2+)-channel.
Topics: Animals; Astrocytes; Calcium; Calcium Channels; Calpain; Cell Membrane; Cerebellum; Chromatography, Affinity; Dipeptides; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Leupeptins; Male; Molecular Weight; Neurons; Phosphorylation; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Testis; Tumor Cells, Cultured; Vas Deferens | 1993 |
Proteolysis results in altered leak channel kinetics and elevated free calcium in mdx muscle.
Topics: Animals; Calcium; Calcium Channels; Calpain; Cells, Cultured; Clenbuterol; Dose-Response Relationship, Drug; Dystrophin; Feedback; Glycoproteins; Kinetics; Leupeptins; Mice; Mice, Mutant Strains; Muscles; Muscular Dystrophy, Animal | 1993 |
Evidence for protein kinase C stimulation in rat enterocytes pretreated with heat stable enterotoxin of Escherichia coli.
Topics: Alkaloids; Animals; Bacterial Toxins; Calcium; Calmodulin; Cyclic AMP; Cyclic GMP; Diglycerides; Enterotoxins; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Intestinal Mucosa; Jejunum; Leupeptins; Magnesium; Membrane Proteins; Phosphatidylserines; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Rats; Signal Transduction; Staurosporine | 1993 |
A system for characterizing cellular and molecular events in programmed neuronal cell death.
Topics: Animals; Apoptosis; Aurintricarboxylic Acid; Bucladesine; Cell Division; Cell Survival; Dactinomycin; DNA, Neoplasm; Epidermal Growth Factor; Fibroblast Growth Factor 2; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Nerve Growth Factors; Neurons; PC12 Cells; Time Factors; Transcription, Genetic; Video Recording | 1993 |
Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo.
Topics: Antigens, Differentiation, B-Lymphocyte; Biological Transport; Cell Line; Centrifugation, Density Gradient; Cholic Acids; Chromatography, Gel; Histocompatibility Antigens Class II; Humans; Leupeptins; Molecular Weight; Peptide Fragments | 1993 |
X-ray crystallographic structure of a papain-leupeptin complex.
Topics: Amino Acid Sequence; Binding Sites; Crystallography; In Vitro Techniques; Leupeptins; Models, Molecular; Molecular Sequence Data; Papain; Protein Structure, Tertiary; X-Ray Diffraction | 1993 |
Leupeptin-binding site(s) in the mammalian multicatalytic proteinase complex.
Topics: Amino Acid Sequence; Animals; Antipain; Binding Sites; Cysteine Endopeptidases; Ethylmaleimide; Leupeptins; Liver; Molecular Sequence Data; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; Trypsin | 1993 |
beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
Topics: Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anti-Bacterial Agents; Base Sequence; Brefeldin A; Cell Line; Cell Membrane; Codon; Colchicine; Cyclopentanes; Golgi Apparatus; Humans; Kidney; Kinetics; Leupeptins; Molecular Sequence Data; Molecular Weight; Monensin; Oligodeoxyribonucleotides; Peptide Fragments; Sequence Deletion; Transfection | 1993 |
Effects of brefeldin A on cleavage of invariant chain to p21 and p10 and the appearance of Ii-freed class II MHC dimers.
Topics: Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; Binding Sites; Brefeldin A; Cell Compartmentation; Cyclopentanes; Golgi Apparatus; Histocompatibility Antigens Class II; Leupeptins; Tumor Cells, Cultured | 1993 |
Successful 7-day perfusion preservation of the canine kidney.
Topics: Adenosine; Allopurinol; Animals; Benzamidines; Creatinine; Dogs; Female; Glutathione; Graft Survival; Insulin; Kidney; Kidney Transplantation; Leupeptins; Mersalyl; Mitochondria; Organ Preservation; Organ Preservation Solutions; Oxygen Consumption; Perfusion; Quinacrine; Raffinose; Solutions; Time Factors | 1993 |
Uptake of ferritin by isolated rat hepatocytes. Effect of metabolic inhibitors and iron.
Topics: Animals; Antimetabolites; Cell Survival; Chloroquine; Endocytosis; Ferritins; Iodine Radioisotopes; Iron; Leupeptins; Liver; Monensin; Rats; Rats, Wistar; Trypan Blue | 1993 |
Invariant chain retains MHC class II molecules in the endocytic pathway.
Topics: Ammonium Chloride; Animals; Antigens, Differentiation, B-Lymphocyte; Cell Line; Chloroquine; Endocytosis; Histocompatibility Antigens Class II; Leupeptins; Lysosomes; Primaquine | 1993 |
Factors affecting secretory protein production in primary cultures of rat hepatocytes.
Topics: Amino Acids; Animals; Cells, Cultured; Culture Media; Dexamethasone; Epinephrine; Glucagon; Insulin; Kinetics; Leupeptins; Liver; Male; Rats; Rats, Sprague-Dawley; Serum Albumin; Urea | 1993 |
Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo.
Topics: Animals; Blood Pressure; Calpain; Cells, Cultured; Glycoproteins; Hypoxia, Brain; Ischemic Attack, Transient; Leupeptins; Male; Neurons; Prosencephalon; Rats; Rats, Wistar | 1993 |
Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes.
Topics: 3T3 Cells; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Cycloheximide; Endoplasmic Reticulum; Golgi Apparatus; Hexosaminidases; Leupeptins; Lysosomes; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Peptide Fragments; Receptors, Erythropoietin | 1993 |
Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate.
Topics: Animals; Antimalarials; Cell Division; Chloroquine; Drug Resistance; Humans; Leupeptins; Orotic Acid; Plasmodium falciparum | 1993 |
Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system.
Topics: Animals; Antigen Presentation; Antigens, Differentiation, B-Lymphocyte; ATP-Binding Cassette Transporters; Cell Compartmentation; Chloroquine; Drug Resistance; Epitopes; Glycoproteins; Histocompatibility Antigens Class II; Hybridomas; Leupeptins; Lymphocyte Activation; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nucleoproteins; T-Lymphocytes; Viral Structural Proteins | 1995 |
The mutation Gly142-->Glu in human lipoprotein lipase produces a missorted protein that is diverted to lysosomes.
Topics: Animals; Base Sequence; Cell Compartmentation; Cells, Cultured; Chlorocebus aethiops; DNA Primers; Fluorescent Antibody Technique, Indirect; Heparin; Humans; Immunohistochemistry; Leupeptins; Lipoprotein Lipase; Lysosomes; Microscopy, Fluorescence; Molecular Sequence Data; Mutagenesis, Site-Directed; Protease Inhibitors; Structure-Activity Relationship; Transfection | 1996 |
Intracellular generation of amyloid beta-protein from amyloid beta-protein precursor fragment by direct cleavage with beta- and gamma-secretase.
Topics: Alzheimer Disease; Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Base Sequence; Cell Line; Chlorocebus aethiops; DNA Primers; Endopeptidases; Humans; Kinetics; Leupeptins; Methylamines; Molecular Sequence Data; Peptide Fragments; Polymerase Chain Reaction; Protease Inhibitors; Protein Processing, Post-Translational; Recombinant Proteins; Transfection | 1996 |
Neuromuscular recovery after peripheral nerve repair: effects of an orally-administered peptide in a primate model.
Topics: Administration, Oral; Animals; Biological Availability; Calpain; Cebus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Leupeptins; Male; Median Nerve; Microsurgery; Motor Neurons; Muscle, Skeletal; Nerve Regeneration; Neural Conduction; Neuromuscular Junction; Protease Inhibitors; Wound Healing | 1995 |
Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases.
Topics: Amino Acid Sequence; Animals; Aprotinin; Base Sequence; Benzamidines; Cattle; DNA; Electrochemistry; Enzyme Activation; Enzyme Precursors; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Leupeptins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Rats; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Thermodynamics; Trypsin; Trypsin Inhibitors | 1996 |
Early proteolytic cleavage with loss of a C-terminal fragment underlies altered processing of the beta-galactosidase precursor in galactosialidosis.
Topics: Animals; beta-Galactosidase; Cells, Cultured; CHO Cells; Cricetinae; Endopeptidases; Enzyme Precursors; Fibroblasts; Gangliosidosis, GM1; Humans; Leupeptins; Lysosomal Storage Diseases; Molecular Weight; Protein Processing, Post-Translational | 1996 |
Generation of VV-hemorphin-7 from globin by peritoneal macrophages.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cathepsin D; Cattle; Cells, Cultured; Female; Globins; Hemoglobins; Hydrolysis; Leupeptins; Lysosomes; Macrophages, Peritoneal; Mice; Molecular Sequence Data; Pepstatins; Peptide Fragments; Protease Inhibitors; Specific Pathogen-Free Organisms | 1996 |
Intracellular degradation in the regulation of secretion of apolipoprotein B-100 by rabbit hepatocytes.
Topics: Animals; Apolipoprotein B-100; Apolipoproteins B; Aprotinin; Cells, Cultured; Chlorides; Endoplasmic Reticulum, Rough; Endoplasmic Reticulum, Smooth; Glycoproteins; Golgi Apparatus; Homeostasis; Kinetics; Leupeptins; Liver; Methionine; Oleic Acid; Oleic Acids; Phenanthrolines; Protease Inhibitors; Rabbits; Sulfur Radioisotopes; Zinc Compounds | 1996 |
Secretion of human intestinal angiotensin-converting enzyme and its association with the differentiation state of intestinal cells.
Topics: Aprotinin; Biopsy; Cell Differentiation; Humans; Intestinal Mucosa; Intestine, Small; Isoenzymes; Lectins; Leupeptins; Microvilli; Peptidyl-Dipeptidase A; Protease Inhibitors | 1996 |
Stabilisation of neuromuscular junctions by leupeptin increases motor unit size in partially denervated rat muscles.
Topics: Animals; Calpain; Cell Size; Leupeptins; Motor Neurons; Muscle Denervation; Nerve Endings; Neuromuscular Junction; Rats; Rats, Wistar | 1995 |
Leupeptin causes an accumulation of lipofuscin-like substances and other signs of aging in kidneys of young rats: further evidence for the protease inhibitor model of aging.
Topics: Aging; Animals; Kidney; Leupeptins; Lipofuscin; Male; Microscopy, Electron; Models, Biological; Protease Inhibitors; Rats; Rats, Inbred F344 | 1996 |
Efficacy of serine protease inhibitors against Cryptosporidium parvum infection in a bovine fallopian tube epithelial cell culture system.
Topics: alpha 1-Antitrypsin; Amino Acid Chloromethyl Ketones; Animals; Antipain; Aprotinin; Cattle; Cells, Cultured; Cryptosporidium parvum; Epithelial Cells; Epithelium; Fallopian Tubes; Female; Leupeptins; Phenylmethylsulfonyl Fluoride; Serine Proteinase Inhibitors; Trypsin Inhibitors | 1996 |
Proteinases in renal cell death.
Topics: Animals; Anti-Bacterial Agents; Antimycin A; Antipain; Carboxypeptidases; Cathepsin A; Cathepsin B; Cell Death; Coumarins; Cysteine; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endopeptidases; Hydrocarbons, Fluorinated; Hydroquinones; Isocoumarins; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Leucine; Leupeptins; Lysosomes; Membrane Potentials; Pepstatins; Peroxides; Rabbits; Reactive Oxygen Species; Serine Proteinase Inhibitors; tert-Butylhydroperoxide; Tosyllysine Chloromethyl Ketone | 1996 |
Uncleaved env gp160 of human immunodeficiency virus type 1 is degraded within the Golgi apparatus but not lysosomes in COS-1 cells.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Chlorocebus aethiops; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; Gene Products, env; Genes, env; Golgi Apparatus; HIV Envelope Protein gp160; HIV-1; Humans; Kinetics; Leupeptins; Lysosomes; Macrolides; Protein Precursors; Recombinant Proteins; Time Factors; Transfection | 1996 |
Selective uptake and degradation of c-Fos and v-Fos by rat liver lysosomes.
Topics: Animals; Cell Line; Cell-Free System; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Kinetics; Leupeptins; Liver; Lysosomes; Oncogene Proteins v-fos; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Recombinant Proteins; Transfection; Trypsin | 1996 |
Activity-induced internalization and rapid degradation of sodium channels in cultured fetal neurons.
Topics: Amphotericin B; Animals; Brain; Cells, Cultured; Endocytosis; Iodine Radioisotopes; Leupeptins; Neurons; Rats; Rats, Wistar; Scorpion Venoms; Scorpions; Sodium Channels; Time; Veratridine | 1996 |
tBHP induced in vitro swelling of rat liver mitochondria.
Topics: Animals; Antipain; Deferoxamine; Dibucaine; Edetic Acid; Egtazic Acid; Kinetics; Leupeptins; Male; Mitochondria, Liver; Mitochondrial Swelling; Peroxides; Phospholipases A; Phospholipases A2; Protease Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Spermine; tert-Butylhydroperoxide | 1996 |
Vitamin A incorporation into lipofuscin-like inclusions in the retinal pigment epithelium.
Topics: Animals; Inclusion Bodies; Leupeptins; Lipofuscin; Male; Pigment Epithelium of Eye; Protease Inhibitors; Rats; Rats, Inbred F344; Vitamin A | 1995 |
Trypsin-like protease of Streptomyces exfoliatus SMF13, a potential agent in mycelial differentiation.
Topics: Amino Acid Sequence; Endopeptidases; Glucose; Kinetics; Leupeptins; Microscopy, Electron, Scanning; Molecular Sequence Data; Mutation; Oligopeptides; Protease Inhibitors; Sequence Homology, Amino Acid; Streptomyces; Substrate Specificity; Trypsin | 1996 |
Polarized GP2 secretion in MDCK cells via GPI targeting and apical membrane-restricted proteolysis.
Topics: Animals; Antipain; Aprotinin; Cell Line; Cell Membrane; Cell Polarity; Cytoplasmic Granules; Dogs; Endopeptidases; Glycosylphosphatidylinositols; GPI-Linked Proteins; Kidney; Leupeptins; Membrane Glycoproteins; Molecular Weight; Pancreas; Peptide Hydrolases; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Type C Phospholipases | 1996 |
Inhibitors of Ca(2+)-dependent endopeptidases modulate morphine-induced effects in rats.
Topics: Animals; Antipain; Drug Synergism; Leupeptins; Male; Morphine; Morphine Dependence; Pain Measurement; Pain Threshold; Protease Inhibitors; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1996 |
Induction of apoptosis in primary culture of rat hepatocytes by protease inhibitors.
Topics: Animals; Apoptosis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cathepsins; Cell Nucleus; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Electrophoresis, Agar Gel; Female; Glycoproteins; Leupeptins; Liver; Lysosomes; Microscopy, Fluorescence; Protease Inhibitors; Rats; Rats, Wistar; Transforming Growth Factor beta | 1996 |
Inhibition of coronavirus MHV-A59 replication by proteinase inhibitors.
Topics: Animals; Cell Line; Giant Cells; Kinetics; Leupeptins; Mice; Murine hepatitis virus; Protease Inhibitors; RNA-Dependent RNA Polymerase; RNA, Viral; Time Factors; Uridine; Viral Plaque Assay; Virus Replication | 1995 |
ATP is required in platelet serotonin exocytosis for protein phosphorylation and priming of secretory vesicles docked on the plasma membrane.
Topics: Adenosine Triphosphate; Animals; Blood Platelets; Calcium; Calpain; Cattle; Cell Membrane; Culture Media; Cytoplasmic Granules; Exocytosis; Leupeptins; Magnesium; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Serotonin | 1996 |
Different effects of modulation of mosquito (Diptera:Culicidae) trypsin activity on the infectivity of two human malaria (Hemosporidia:Plasmodidae) parasites.
Topics: Animals; Anopheles; Chymotrypsin; Humans; Leupeptins; Plasmodium falciparum; Plasmodium vivax; Rabbits; Trypsin; Trypsin Inhibitors | 1996 |
Two crystal structures of the leupeptin-trypsin complex.
Topics: Binding Sites; Crystallography, X-Ray; Leupeptins; Oxygen; Protein Conformation; Trypsin | 1996 |
Phorbol ester, but not endotoxin, desensitizes mannan-induced glycogenolysis in the perfused rat liver.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aprotinin; Calcimycin; Colforsin; Enzyme Inhibitors; Escherichia coli; Leupeptins; Lipopolysaccharides; Liver; Liver Glycogen; Male; Mannans; Norepinephrine; Perfusion; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1996 |
Absence of lysosomal cleavage in the cytotoxicity mechanism of an immunoconjugate composed of anti-alpha-fetoprotein monoclonal antibody and vindesine analog.
Topics: alpha-Fetoproteins; Ammonium Chloride; Animals; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Cell Survival; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Endocytosis; Humans; Immunotoxins; Leupeptins; Liver; Lysosomes; Male; Rats; Rats, Wistar; Tumor Cells, Cultured; Vindesine | 1996 |
The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Cathepsin B; Computer Simulation; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Precursors; Fruit; Hydrogen Bonding; Leucine; Leupeptins; Models, Molecular; Molecular Sequence Data; Mutation; Oligopeptides; Papain; Plant Proteins; Protein Processing, Post-Translational; Protein Structure, Secondary; Sequence Homology, Amino Acid | 1996 |
HLA-DM is present in one-fifth the amount of HLA-DR in the class II peptide-loading compartment where it associates with leupeptin-induced peptide (LIP)-HLA-DR complexes.
Topics: Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Compartmentation; Histocompatibility Antigens Class II; HLA-D Antigens; HLA-DR Antigens; Humans; Leupeptins; Macromolecular Substances; Peptide Fragments; Peptides; Precipitin Tests; Protein Binding | 1996 |
Degradation of lactoferrin by periodontitis-associated bacteria.
Topics: Aggregatibacter actinomycetemcomitans; Bacteria; Bacteroides; Campylobacter; Capnocytophaga; Enzyme Inhibitors; Fusobacterium nucleatum; Humans; Iodoacetamide; Lactoferrin; Leupeptins; Peptostreptococcus; Periodontitis; Phenylmethylsulfonyl Fluoride; Porphyromonas gingivalis; Prevotella intermedia; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1996 |
Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; CHO Cells; Colchicine; Cricetinae; Dihydropyridines; Drug Resistance, Multiple; Kinetics; Leupeptins; Oligopeptides; Substrate Specificity; Vinblastine | 1996 |
Novel anticoagulants for flow cytometric analysis of live leucocytes in whole blood.
Topics: Adult; Amino Acid Chloromethyl Ketones; Anticoagulants; Aprotinin; Blood; Blood Cell Count; Citrates; Flow Cytometry; Hirudins; Humans; L-Selectin; Leukocytes; Leukocytes, Mononuclear; Leupeptins; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenylmethylsulfonyl Fluoride; Sulfones | 1996 |
Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cathepsin B; Colonic Neoplasms; Dimethylhydrazines; Esters; Gabexate; Guanidines; Leupeptins; Male; Protease Inhibitors; Rats | 1996 |
Distinct antigen MHC class II complexes generated by separate processing pathways.
Topics: Cell Line; Chloroquine; Histocompatibility Antigens Class II; Kinetics; Leupeptins; Protein Binding; Protein Folding; Protein Processing, Post-Translational; Sodium Dodecyl Sulfate | 1996 |
Transfer of free polymannose-type oligosaccharides from the cytosol to lysosomes in cultured human hepatocellular carcinoma HepG2 cells.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Biological Transport; Carbohydrate Sequence; Carcinoma, Hepatocellular; Cell Fractionation; Cell Membrane Permeability; Cytosol; Enzyme Inhibitors; Golgi Apparatus; Humans; Leupeptins; Liver Neoplasms; Lysosomes; Macrolides; Mannans; Mannose; Molecular Sequence Data; Oligosaccharides; Proton-Translocating ATPases; Streptolysins; Swainsonine; Tumor Cells, Cultured | 1997 |
Granulocytic protein p25 is a DNA-binding subunit of protein M(r) = 50,000: subcellular localization, cell and species specificity.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antigen-Antibody Reactions; Chromobox Protein Homolog 5; DNA-Binding Proteins; Granulocytes; Humans; In Vitro Techniques; Leupeptins; Molecular Sequence Data; Pepstatins; Protease Inhibitors; Reference Values; Species Specificity; Subcellular Fractions | 1996 |
A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins.
Topics: Adenosine Triphosphate; Animals; Cell Compartmentation; Cytosol; Glyceraldehyde-3-Phosphate Dehydrogenases; Heat-Shock Proteins; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Liver; Lysosomes; Male; Microscopy, Electron; Rats; Rats, Wistar; Ribonuclease, Pancreatic | 1997 |
Production of an extracellular trypsin-like protease by the fungal plant pathogen Verticillium dahliae.
Topics: Amino Acid Sequence; Animals; Benzoylarginine Nitroanilide; Biomass; Chromatography, Ion Exchange; Culture Media; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Leupeptins; Milk; Mitosporic Fungi; Molecular Sequence Data; Sequence Homology, Amino Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Time Factors | 1997 |
Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes.
Topics: Animals; Antigens, Surface; Biological Transport; Cell Compartmentation; Cell Membrane; Dimerization; Electrophoresis; Histocompatibility Antigens Class II; Leupeptins; Lymphoma; Lysosomes; Mice; Microscopy, Immunoelectron; Protein Structure, Tertiary; Tumor Cells, Cultured | 1997 |
Memory disturbance and hippocampal degeneration induced by continuous intraventricular infusion of a protease inhibitor, leupeptin.
Topics: Animals; Avoidance Learning; Axons; Cerebral Ventricles; Cytoplasmic Granules; Dendrites; Dentate Gyrus; Hippocampus; Infusions, Parenteral; Leupeptins; Lipofuscin; Memory; Memory Disorders; Motor Activity; Nerve Degeneration; Neurons; Rats; Rats, Wistar | 1997 |
Selective increased presentation of type II collagen by leupeptin.
Topics: Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; Brefeldin A; Collagen; Cyclopentanes; Dimerization; Epitopes; Histocompatibility Antigens Class II; Immunophenotyping; Leupeptins; Lymphoma, B-Cell; Mice; Mice, Inbred DBA; Protease Inhibitors; Protein Synthesis Inhibitors; Sodium Dodecyl Sulfate; Tumor Cells, Cultured | 1997 |
Thrombin receptor-activating peptide releases arachidonic acid from human platelets: a comparison with thrombin and trypsin.
Topics: Arachidonic Acid; Blood Platelets; Humans; Leupeptins; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Trypsin | 1997 |
Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes.
Topics: Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Autophagy; Cell Separation; Cellobiose; Endocytosis; Iodine Radioisotopes; Leupeptins; Liver; Male; Okadaic Acid; Orosomucoid; Pinocytosis; Propylamines; Rats; Rats, Wistar; Receptors, Cell Surface; Serum Albumin, Bovine; Subcellular Fractions; Tyramine; Vinblastine | 1997 |
Differentiation-induced changes in the content, secretion, and subcellular distribution of lysosomal cathepsins in the human colon cancer HT-29 cell line.
Topics: Ammonium Chloride; Cathepsin B; Cathepsin D; Cathepsin L; Cathepsins; Cell Differentiation; Colon; Colonic Neoplasms; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; HT29 Cells; Humans; Leupeptins; Lysosomes; Mannosephosphates | 1997 |
Thrombin regulates nerve growth factor secretion from vascular, but not bladder smooth muscle cells.
Topics: Animals; Aorta; Aprotinin; Cells, Cultured; Hirudins; Leupeptins; Muscle, Smooth; Muscle, Smooth, Vascular; Nerve Growth Factors; Protease Inhibitors; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Thrombin; Trypsin; Urinary Bladder | 1997 |
Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing.
Topics: Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; CD4-Positive T-Lymphocytes; Colonic Neoplasms; Cysteine Endopeptidases; Dimerization; DNA Primers; Endopeptidases; Histocompatibility Antigens Class II; HLA-D Antigens; HLA-DQ Antigens; HLA-DR Antigens; Humans; Interferon-gamma; Intestinal Mucosa; Leupeptins; Polymerase Chain Reaction; Protease Inhibitors; Recombinant Proteins; Transfection; Tumor Cells, Cultured | 1997 |
Effects of lysosomal protease inhibitors on the degradation of acetylated low density lipoprotein in cultured rat peritoneal macrophages.
Topics: Acetylation; Animals; Cells, Cultured; Cholesterol; Humans; Iodine Radioisotopes; Leupeptins; Lipoproteins, LDL; Lysosomes; Macrophages, Peritoneal; Oleic Acid; Pepstatins; Protease Inhibitors; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tritium | 1994 |
Utilization of intracellular ferritin iron for hemoglobin synthesis in developing human erythroid precursors.
Topics: Autoradiography; Cells, Cultured; Chloroquine; Enzyme-Linked Immunosorbent Assay; Erythroblasts; Erythroid Precursor Cells; Ferritins; Flow Cytometry; Heme; Hemoglobins; Humans; Iron; Iron Radioisotopes; Kinetics; Leupeptins; Oligopeptides; Protease Inhibitors | 1997 |
Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.
Topics: Antibiotics, Antineoplastic; Antipain; Apoptosis; Ceramides; Coumarins; Daunorubicin; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; HL-60 Cells; Humans; Hydrolysis; Isocoumarins; Leupeptins; NF-kappa B; Pepstatins; Protease Inhibitors; Serine Proteinase Inhibitors; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured | 1997 |
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism.
Topics: Amino Acid Sequence; Animals; Antigens, Differentiation, B-Lymphocyte; Cathepsin D; Cathepsins; Cricetinae; Cysteine Proteinase Inhibitors; Histocompatibility Antigens Class II; Leupeptins; Mice; Molecular Sequence Data; Polymorphism, Genetic; Rabbits | 1997 |
Interaction of combinations of drugs, chemosensitizers, and peptides with the P-glycoprotein multidrug transporter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Membrane; Colchicine; Cyclosporine; Drug Interactions; Drug Resistance, Multiple; Leupeptins; Oligopeptides; Peptides; Reserpine; Valinomycin; Vinblastine | 1997 |
MHC class II-associated invariant chain-induced enlarged endosomal structures: a morphological study.
Topics: Adenine; Antigens, CD; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Endocytosis; Endosomes; Fibroblasts; HLA-DR alpha-Chains; HLA-DR Antigens; Humans; Immunohistochemistry; Leupeptins; Lysosomal Membrane Proteins; Lysosomes; Macromolecular Substances; Membrane Glycoproteins; Receptor, IGF Type 2; Recombinant Proteins; Transfection | 1997 |
Efficient photoaffinity labeling of the rat V1a vasopressin receptor using a linear azidopeptidic antagonist.
Topics: Affinity Labels; Animals; Antidiuretic Hormone Receptor Antagonists; Azides; Cell Membrane; COS Cells; Electrophoresis, Polyacrylamide Gel; Female; Hydrolysis; Leupeptins; Liver; Magnetic Resonance Spectroscopy; Male; Oligopeptides; Photochemistry; Rats; Rats, Wistar; Receptors, Vasopressin; Recombinant Proteins; Spectrophotometry, Ultraviolet; Spodoptera; Zinc | 1997 |
Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.
Topics: Adrenergic beta-Antagonists; Animals; Benzimidazoles; Bradykinin; Calcium; Cells, Cultured; Chymases; Colon; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Gastrointestinal Motility; In Vitro Techniques; Indomethacin; Inflammation Mediators; Leupeptins; Mast Cells; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitroprusside; Rats; Receptor, PAR-2; Receptors, Cell Surface; Serine Endopeptidases; Substance P; Tetrodotoxin; Time Factors; Trypsin; Tryptases | 1997 |
Myoblast fusion requires fibronectin degradation by exteriorized m-calpain.
Topics: Animals; Calpain; Cell Fusion; Cells, Cultured; Cysteine Proteinase Inhibitors; Fibronectins; Leupeptins; Muscle, Skeletal; Peptide Fragments; Protease Inhibitors; Rabbits; Rats; Rats, Wistar | 1997 |
Calcium homeostasis of isolated single cortical fibers of rat lens.
Topics: Aniline Compounds; Animals; Benzofurans; Calcium; Calcium Channel Blockers; Fluorescent Dyes; Homeostasis; Imidazoles; Lens Cortex, Crystalline; Leupeptins; Nickel; Organic Chemicals; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Verapamil; Xanthenes; Zinc | 1997 |
Fluorometric analysis of endocytosis and lysosomal proteolysis in the rat visceral yolk sac during whole embryo culture.
Topics: Animals; Cell Culture Techniques; Embryo, Mammalian; Endocytosis; Endopeptidases; Enzyme Inhibitors; Female; Fluorescein-5-isothiocyanate; Leupeptins; Lysosomes; Microscopy, Fluorescence; Pregnancy; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Spectrometry, Fluorescence; Yolk Sac | 1997 |
The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Carbachol; Cholinesterase Inhibitors; Culture Media, Conditioned; HeLa Cells; Humans; Immunoblotting; Leupeptins; Parasympathomimetics; Protease Inhibitors; Tacrine | 1997 |
Oxygen deprivation inhibits Na+ current in rat hippocampal neurones via protein kinase C.
Topics: Animals; Cell Hypoxia; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hippocampus; Isoquinolines; Leupeptins; Naphthalenes; Nerve Tissue Proteins; Neurons; Oxygen; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channels; Sulfonamides | 1997 |
Smokeless tobacco-exposed oral keratinocytes increase macromolecular efflux from the in situ oral mucosa.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Cells, Cultured; Cheek; Cricetinae; Dextrans; Fluorescein-5-isothiocyanate; Humans; Keratinocytes; Kinetics; Leupeptins; Male; Mesocricetus; Microcirculation; Mouth Mucosa; Plants, Toxic; Tobacco, Smokeless | 1998 |
Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Compartmentation; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Kidney; Leupeptins; Lysosomes; Microscopy, Confocal; Multienzyme Complexes; Opossums; Parathyroid Hormone; Phosphates; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type II; Symporters | 1998 |
Inhibitory effects of human alpha 2-macroglobulin on Trypanosoma cruzi epimastigote proteinases.
Topics: alpha-Macroglobulins; Animals; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Leupeptins; Protease Inhibitors; Time Factors; Tosyl Compounds; Trypanosoma cruzi | 1997 |
Mtv-1 superantigen trafficks independently of major histocompatibility complex class II directly to the B-cell surface by the exocytic pathway.
Topics: Animals; Antigen Presentation; Antigens, Viral; B-Lymphocytes; Biological Transport; Blotting, Western; Cell Membrane; Centrifugation, Density Gradient; Exocytosis; Hexosaminidases; Histocompatibility Antigens Class II; Leupeptins; Lysosomes; Mice; Sodium Dodecyl Sulfate; Superantigens; Tumor Cells, Cultured | 1998 |
Characterization of the leupeptin-inactivating enzyme from Streptomyces exfoliatus SMF13 which produces leupeptin.
Topics: Amino Acid Sequence; Chromatography; Edetic Acid; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Hydrolysis; Leucine; Leupeptins; Metalloendopeptidases; Microscopy, Electron, Scanning; Molecular Weight; Peptide Fragments; Phenanthrolines; Streptomyces; Substrate Specificity | 1998 |
Carboxy-terminal truncation of long-tailed amyloid beta-peptide is inhibited by serine protease inhibitor and peptide aldehyde.
Topics: Amino Acids; Amyloid beta-Peptides; Animals; Antipain; Brain; Carboxypeptidases; Chloromercuribenzoates; Edetic Acid; Leupeptins; p-Chloromercuribenzoic Acid; Pepstatins; Peptide Fragments; Phenylmethylsulfonyl Fluoride; Rats; Serine Proteinase Inhibitors | 1998 |
On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes.
Topics: Animals; Cells, Cultured; Ceroid; Exocytosis; Leupeptins; Lipofuscin; Myocardium; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase.
Topics: Amino Acid Sequence; Aminopeptidases; Binding Sites; Carboxypeptidases; Cloning, Molecular; Crystallography, X-Ray; Cysteine Endopeptidases; DNA Primers; Escherichia coli; Kinetics; Leupeptins; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Synthases; Point Mutation; Protein Conformation; Recombinant Proteins; Sequence Deletion | 1998 |
Calcium mediated proteolysis enhances calcium release in skinned L6 myotubes.
Topics: Animals; Caffeine; Calcium; Cell Line; Clone Cells; Dithiothreitol; Endopeptidases; Kinetics; Leupeptins; Muscle Contraction; Muscle, Skeletal; Protease Inhibitors; Rats; Sarcoplasmic Reticulum; Signal Transduction | 1997 |
Deterioration of connectin/titin and nebulin filaments by an excess of protease inhibitors.
Topics: Animals; Calcium-Binding Proteins; Connectin; Cysteine Proteinase Inhibitors; Leupeptins; Muscle Proteins; Myofibrils; Protein Kinases; Rabbits | 1998 |
Purification and characterisation of a tripeptidyl aminopeptidase I from rat spleen.
Topics: Aminopeptidases; Animals; Bone Resorption; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Isoflurophate; Leupeptins; Protease Inhibitors; Rats; Serine Proteases; Spleen; Tripeptidyl-Peptidase 1 | 1998 |
Submandibular salivary proteases: lack of a role in anti-HIV activity.
Topics: Anti-HIV Agents; Aprotinin; Benzamidines; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cysteine Proteinase Inhibitors; Edetic Acid; Egtazic Acid; Endopeptidases; Ethylmaleimide; HIV-1; Humans; Isoflurophate; Leupeptins; Metalloendopeptidases; Norleucine; Parotid Gland; Pepstatins; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Saliva; Serine Proteinase Inhibitors; Submandibular Gland; Trypsin Inhibitor, Bowman-Birk Soybean | 1998 |
Cholesterol sulfate inhibits proteases that are involved in desquamation of stratum corneum.
Topics: Animals; Cholesterol Esters; Epidermis; Humans; Ichthyosis, X-Linked; Leupeptins; Male; Mice; Mice, Hairless; Oligopeptides; Serine Proteinase Inhibitors | 1998 |
Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes.
Topics: Ammonia; Animals; Asparagine; Endocytosis; Endosomes; Gold; Leupeptins; Liver; Male; Microscopy, Electron; Phagosomes; Propylamines; Rats; Rats, Wistar | 1998 |
Efficient class II major histocompatibility complex presentation of endogenously synthesized hepatitis C virus core protein by Epstein-Barr virus-transformed B-lymphoblastoid cell lines to CD4(+) T cells.
Topics: Animals; Antigen-Presenting Cells; B-Lymphocytes; CD4-Positive T-Lymphocytes; Cell Division; Cell Line, Transformed; Chloramphenicol O-Acetyltransferase; COS Cells; Genes, Viral; Herpesvirus 4, Human; Histocompatibility Antigens Class II; Leupeptins; Viral Core Proteins; Viral Structural Proteins | 1998 |
Endocytosed ricin and asialoorosomucoid follow different intracellular pathways in hepatocytes.
Topics: Animals; Asialoglycoproteins; Centrifugation, Density Gradient; Culture Media; Endocytosis; Iodine Radioisotopes; Leupeptins; Liver; Male; Orosomucoid; Osmolar Concentration; Rats; Rats, Wistar; Ricin; Subcellular Fractions; Vinblastine | 1998 |
Vasopressin-induced disruption of actin cytoskeletal organization and canalicular function in isolated rat hepatocyte couplets: possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Antioxidants; Bile Canaliculi; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Indoles; Leupeptins; Liver; Male; Microscopy, Electron, Scanning; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Rats; Rats, Wistar; Tight Junctions; Vacuoles; Vasopressins | 1998 |
Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Antibodies, Monoclonal; Aprotinin; Cathepsins; Female; Frontal Lobe; Glial Fibrillary Acidic Protein; Gliosis; In Situ Nick-End Labeling; Leupeptins; Lysosomes; Microscopy, Confocal; Neuroglia; Neurons; Neurotoxins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Thalamus | 1998 |
Parathyroid hormone and dietary phosphate provoke a lysosomal routing of the proximal tubular Na/Pi-cotransporter type II.
Topics: Animals; Carrier Proteins; Diet; Immunohistochemistry; Kidney Tubules, Proximal; Leupeptins; Lysosomes; Microvilli; Parathyroid Hormone; Phosphates; Rats; Sodium; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type II; Symporters | 1998 |
Differential toxicity of protease inhibitors in cultures of cerebellar granule neurons.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebellum; Cysteine Proteinase Inhibitors; Dipeptides; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Leupeptins; Neurons; Oligopeptides; Protease Inhibitors; Rats; Rats, Wistar | 1998 |
Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes.
Topics: Adenosine Triphosphate; Animals; Calcium; Calpain; Cathepsin B; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Deoxyglucose; Dexamethasone; Leucine; Leupeptins; Methylamines; Mifepristone; Multienzyme Complexes; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteins; Rats; Tyrosine; Ubiquitins | 1998 |
Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (A beta) 1-42 peptide in a murine N9 microglial cell line.
Topics: Amyloid beta-Peptides; Animals; Biological Transport; Cell Line; Cells, Cultured; Chloroquine; Kinetics; Leupeptins; Membrane Proteins; Mice; Microglia; Peptide Fragments; Polysaccharides; Rats; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class B | 1998 |
Synthesis, assembly, and intracellular transport of the platelet glycoprotein Ib-IX-V complex.
Topics: Biological Transport; Brefeldin A; Cell Compartmentation; Cell Line; Cell Membrane; Endoplasmic Reticulum; Golgi Apparatus; Leupeptins; Lysosomes; Platelet Glycoprotein GPIb-IX Complex; Protein Processing, Post-Translational; Recombinant Proteins; Transfection | 1998 |
[Cell to cell transfer of dense bodies induced by intracisternal infusion of leupeptin in rat cerebellum--quantitative and ultrastructural studies].
Topics: Animals; Cerebellum; Cisterna Magna; Histocytochemistry; Leupeptins; Lipofuscin; Male; Neuroglia; Protease Inhibitors; Purkinje Cells; Rats; Rats, Sprague-Dawley | 1998 |
Exposure to lysosomotropic amines and protease inhibitors retard corneal endothelial cell migration along the natural basement membrane during wound repair.
Topics: Amines; Animals; Antipain; Basement Membrane; Cell Movement; Chloroquine; Culture Techniques; Descemet Membrane; Endopeptidases; Endothelium, Corneal; Freezing; Leupeptins; Lysosomes; Metalloendopeptidases; Methylamines; Propylamines; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Trypsin Inhibitor, Kunitz Soybean; Wound Healing | 1999 |
Reversible accumulation of lipofuscin-like inclusions in the retinal pigment epithelium.
Topics: Aging; Animals; Eye Proteins; Inclusion Bodies; Injections; Leupeptins; Lipofuscin; Male; Microscopy, Fluorescence; Pigment Epithelium of Eye; Rats; Rats, Inbred F344; Vitreous Body | 1999 |
Degradation of serum albumin by rat liver and kidney lysosomes.
Topics: Animals; Cathepsins; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Electrophoresis, Polyacrylamide Gel; Kidney; Leupeptins; Liver; Lysosomes; Male; Pepstatins; Rats; Rats, Wistar; Serum Albumin | 1998 |
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Animals; Carcinoma, Squamous Cell; Cathepsin B; Cathepsin C; Cathepsin L; Cathepsins; Cattle; Cystatin A; Cystatin B; Cystatin C; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Female; Humans; Kinetics; Leupeptins; Lung; Lung Neoplasms; Lysosomes; Male; Middle Aged; Sensitivity and Specificity | 1998 |
Tyrosine kinases play a permissive role in glucose-induced insulin secretion from adult rat islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Genistein; Glucose; Insulin; Insulin Secretion; Ion Transport; Islets of Langerhans; Isoflavones; Leupeptins; Phenylmethylsulfonyl Fluoride; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1999 |
A cytomegalovirus glycoprotein re-routes MHC class I complexes to lysosomes for degradation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antigen Presentation; beta 2-Microglobulin; Down-Regulation; Endocytosis; Enzyme Inhibitors; Gene Expression Regulation, Viral; Genes, Viral; Histocompatibility Antigens Class I; Immunohistochemistry; Leupeptins; Lysosomes; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Muromegalovirus; Transfection; Viral Proteins | 1999 |
Activation of Xenopus eggs by proteases: possible involvement of a sperm protease in fertilization.
Topics: Animals; Aprotinin; Calcium; Cathepsin B; Cell Division; Coumarins; Electrophysiology; Endopeptidases; Fertilization; Kinetics; Leupeptins; Male; Oligopeptides; Oocytes; Protease Inhibitors; Salamandridae; Spermatozoa; Substrate Specificity; Xenopus | 1999 |
Acceleration of Ca2+ ionophore-induced arachidonic acid liberation by thrombin without the proteolytic action toward the receptor in human platelets.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arachidonic Acid; Blood Platelets; Calcium; Enzyme Activation; Hirudins; Humans; Ionomycin; Ionophores; Leukocyte Elastase; Leupeptins; Peptide Fragments; Phospholipases A; Phospholipases A2; Platelet Glycoprotein GPIb-IX Complex; Receptor, PAR-1; Receptors, Thrombin; Thrombin; Trypsin | 1999 |
Tissue plasminogen activator mediates reverse occlusion plasticity in visual cortex.
Topics: Animals; Animals, Newborn; Cats; Cell Size; Fibrinolysin; Geniculate Bodies; Leupeptins; Neuronal Plasticity; Plasminogen Activators; Sensory Deprivation; Tissue Plasminogen Activator; Vision, Monocular; Visual Cortex | 1998 |
Persyn, a member of the synuclein family, influences neurofilament network integrity.
Topics: Calcium; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Endopeptidases; gamma-Synuclein; Leupeptins; Neoplasm Proteins; Nerve Tissue Proteins; Neurofilament Proteins; Neurons, Afferent | 1998 |
Leupeptin protects sensory hair cells from acoustic trauma.
Topics: Animals; Antineoplastic Agents; Calpain; Carboplatin; Chinchilla; Enzyme Inhibitors; Hair Cells, Auditory; Hearing Disorders; Hearing Loss, Noise-Induced; Immunohistochemistry; Leupeptins; Organ of Corti | 1999 |
Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum.
Topics: Amiloride; Animals; Antimalarials; Bicarbonates; Biological Transport; Chloroquine; Erythrocyte Membrane; Erythrocytes; Hemin; Hemoglobins; Humans; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Plasmodium falciparum; Sodium-Hydrogen Exchangers; Verapamil | 1999 |
Metabolism and degradation products of recombinant human insulin-like growth factor-I in lysosomes of rat kidney.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Glutathione; Humans; Insulin; Insulin-Like Growth Factor I; Kidney; Leupeptins; Lysosomes; Male; Microscopy, Electron; Molecular Sequence Data; Peptide Fragments; Proinsulin; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sequence Analysis | 1999 |
Novel gelatinolytic activities in rat organs.
Topics: Animals; Cattle; Enzyme Inhibitors; Gelatin; Leupeptins; Male; Metalloendopeptidases; Phenanthrolines; Phenylmercuric Acetate; Rats; Rats, Wistar; Serine Endopeptidases | 1999 |
Stable expression of protective protein/cathepsin A-green fluorescent protein fusion genes in a fibroblastic cell line from a galactosialidosis patient. Model system for revealing the intracellular transport of normal and mutated lysosomal enzymes.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; Biological Transport; Carboxypeptidases; Cathepsin A; Cell Line; DNA, Complementary; Fibroblasts; Green Fluorescent Proteins; Humans; Leupeptins; Luminescent Proteins; Lysosomal Storage Diseases; Lysosomes; Macrolides; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Mutation; Protein Processing, Post-Translational; Recombinant Fusion Proteins | 1999 |
Modulation of major histocompatibility complex protein expression by human gamma interferon mediated by cysteine proteinase-adhesin polyproteins of Porphyromonas gingivalis.
Topics: Adhesins, Bacterial; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Epitopes, B-Lymphocyte; Gingipain Cysteine Endopeptidases; Hemagglutinins; HLA-DR Antigens; Humans; Interferon-gamma; Leupeptins; Porphyromonas gingivalis; Proteins; Recombinant Proteins | 1999 |
MHC class II antigen processing in B cells: accelerated intracellular targeting of antigens.
Topics: Animals; Antigen Presentation; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; beta-N-Acetylhexosaminidases; Binding Sites; Catalysis; Cell Compartmentation; Endocytosis; Histocompatibility Antigens Class II; Horseradish Peroxidase; Immune Sera; Intracellular Fluid; Leupeptins; Lysosomal Membrane Proteins; Lysosomes; Membrane Glycoproteins; Mice; Microscopy, Immunoelectron; Peptides; Pinocytosis; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Receptors, Transferrin; Subcellular Fractions; Tumor Cells, Cultured | 1999 |
Involvement of interleukin-1beta in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120-induced apoptosis in the neocortex of rat.
Topics: Animals; Apoptosis; Body Temperature; Cattle; Citrulline; Gene Expression Regulation; HIV Envelope Protein gp120; Humans; In Situ Nick-End Labeling; Injections, Intraventricular; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Kinetics; Leupeptins; Male; Microglia; Neocortex; Rats; Rats, Wistar; Recombinant Proteins; Serum Albumin, Bovine; Sialoglycoproteins; Time Factors | 1999 |
Expression of cathepsin B-like enzyme activity in cell lysate from cultured human normal keratinocytes.
Topics: Benzoylarginine-2-Naphthylamide; Cathepsin B; Cells, Cultured; Child; Cysteine Proteinase Inhibitors; Humans; Hydrolysis; Keratinocytes; Leupeptins; Male | 1998 |
Functional early endosomes are required for maturation of major histocompatibility complex class II molecules in human B lymphoblastoid cells.
Topics: Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Line; Endosomes; Histocompatibility Antigens Class II; Horseradish Peroxidase; Humans; Leupeptins; Lysosomes; Microscopy, Fluorescence; Peroxidases; Precipitin Tests; Transferrin | 1999 |
Colocalization and membrane association of murine hepatitis virus gene 1 products and De novo-synthesized viral RNA in infected cells.
Topics: Animals; Cell Line; Cell Membrane Permeability; Chlorides; Cysteine Proteinase Inhibitors; DNA-Directed RNA Polymerases; HeLa Cells; Humans; Intracellular Membranes; Leucine; Leupeptins; Mice; Murine hepatitis virus; Rabbits; RNA, Viral; Staining and Labeling; Time Factors; Viral Proteins; Zinc Compounds | 1999 |
The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.
Topics: Anemia, Megaloblastic; Animals; Antibodies; Apolipoprotein A-I; Case-Control Studies; Chloroquine; Chromatography, Affinity; Dog Diseases; Dogs; Endocytosis; Epithelial Cells; Female; Humans; Iodine Radioisotopes; Kidney; Leupeptins; Lipoproteins, HDL; Malabsorption Syndromes; Male; Rats; Rats, Wistar; Receptors, Cell Surface; Reference Values; Syndrome; Vitamin B 12 Deficiency; Yolk Sac | 1999 |
Lipofuscin turnover.
Topics: Animals; Cysteine Proteinase Inhibitors; Inclusion Bodies; Injections; Leupeptins; Lipofuscin; Pigment Epithelium of Eye; Rats | 1999 |
Enzymatic modulation of cell volume in C6 glioma cells.
Topics: Brain Neoplasms; Cell Size; Collagenases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glioma; Humans; Ion Channels; Leupeptins; Matrix Metalloproteinase 9; Mechanoreceptors; Peptide Hydrolases; Tumor Cells, Cultured | 1999 |
Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals.
Topics: Antigen Presentation; Antigen-Presenting Cells; B-Lymphocytes; Cell Line, Transformed; Cell Lineage; Epitopes, T-Lymphocyte; Glutamate Decarboxylase; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Leupeptins; Lymphocyte Activation; Pepstatins; Protease Inhibitors; Transfection | 1999 |
Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin.
Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Female; Humans; Leupeptins; Necrosis; Sphingosine; Tumor Cells, Cultured; U937 Cells | 1999 |
Stabilizing neuromuscular contacts reduces motoneuron death caused by paralysis of muscles in neonatal rats.
Topics: Animals; Animals, Newborn; Bungarotoxins; Calpain; Cell Count; Cell Survival; Cholinergic Antagonists; Isometric Contraction; Leupeptins; Motor Neurons; Muscle, Skeletal; Neuromuscular Junction; Neurotoxins; Paralysis; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic | 1999 |
Is lipofuscin eliminated from cells?
Topics: Fibroblasts; Heart; Humans; Inclusion Bodies; Leupeptins; Lipofuscin; Myocardium; Pigment Epithelium of Eye | 1999 |
A role for the proteasome in the light response of the timeless clock protein.
Topics: Acetylcysteine; Animals; Biological Clocks; Cells, Cultured; Circadian Rhythm; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Darkness; Drosophila; Drosophila Proteins; Feedback; Insect Proteins; Leucine; Leupeptins; Light; Multienzyme Complexes; Neurons; Phosphorylation; Phosphotyrosine; Protease Inhibitors; Proteasome Endopeptidase Complex; Ubiquitins | 1999 |
Transgenic Arabidopsis leaf tissue expressing a modified oryzacystatin shows resistance to the field slug Deroceras reticulatum (Müller).
Topics: Animals; Arabidopsis; Cystatins; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Mollusca; Plant Leaves; Plants, Genetically Modified; Recombinant Proteins | 1999 |
Effect of the selective and non-selective cysteine protease inhibitors on the intracellular processing of interleukin 6 by HEPG2 cells.
Topics: Cathepsin B; Cathepsins; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Interleukin-6; Intracellular Fluid; Iodine Radioisotopes; Isotope Labeling; Ketones; Leucine; Leupeptins; Recombinant Proteins; Time Factors; Tumor Cells, Cultured | 1999 |
Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Histocytochemistry; Leupeptins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Microscopy, Electron; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Necrosis | 2000 |
Binding and processing of (125)I-ACTH by isolated rat splenic lymphocytes.
Topics: Adrenocorticotropic Hormone; Agouti Signaling Protein; alpha-MSH; Animals; Binding, Competitive; Endocytosis; Intercellular Signaling Peptides and Proteins; Iodine Radioisotopes; Leupeptins; Lymphocytes; Lysosomes; Male; Monensin; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin; Receptors, Melanocortin; Spleen; Temperature | 1999 |
Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Multienzyme Complexes; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Rats; Rats, Wistar; Ubiquitins | 2000 |
Clathrin-coated lattices and buds on MHC class II compartments do not selectively recruit mature MHC-II.
Topics: Antigens, Differentiation, B-Lymphocyte; Biological Transport, Active; Cell Compartmentation; Cell Line; Clathrin; Coated Pits, Cell-Membrane; Histocompatibility Antigens Class II; Humans; Leupeptins; Lysosomes; Microscopy, Immunoelectron | 2000 |
Intracellular protein degradation and autophagy in isolated pancreatic acini of the rat.
Topics: Adenine; Amines; Amino Acids; Animals; Autophagy; Cells, Cultured; Enzyme Inhibitors; Kinetics; Leupeptins; Lysosomes; Male; Microscopy, Electron; Pancreas; Protein Biosynthesis; Proteins; Rats; Rats, Long-Evans; Vinblastine | 2000 |
Identification of soluble forms of lectin-like oxidized LDL receptor-1.
Topics: Amino Acid Sequence; Animals; Aorta; Aprotinin; Arteriosclerosis; Biotinylation; Cattle; Cell Membrane; CHO Cells; Cricetinae; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Endopeptidases; Endothelium, Vascular; Glycoproteins; Lectins; Leupeptins; Lipoproteins, LDL; Membrane Proteins; Molecular Sequence Data; Pepstatins; Protease Inhibitors; Protein Structure, Tertiary; Receptors, LDL; Receptors, Oxidized LDL; Serine Proteinase Inhibitors; Solubility; Tosyl Compounds; Tosyllysine Chloromethyl Ketone; Tumor Necrosis Factor-alpha | 2000 |
Accumulation and degradation in the endoplasmic reticulum of a truncated ER-60 devoid of C-terminal amino acid residues.
Topics: Acetylcysteine; Animals; Calcium-Binding Proteins; Calnexin; Calreticulin; Carrier Proteins; Cell Membrane; COS Cells; Culture Media; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochalasin B; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Half-Life; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Proteins; Molecular Chaperones; Protein Disulfide-Isomerases; Recombinant Proteins; Ribonucleoproteins | 2000 |
Suppression of endothelin-converting enzyme-1 during buccal mucosal ulcer healing: effect of chronic alcohol ingestion.
Topics: Animals; Apoptosis; Aspartic Acid Endopeptidases; Edetic Acid; Endothelin-Converting Enzymes; Epithelial Cells; Ethanol; Leupeptins; Metalloendopeptidases; Mouth Mucosa; Oral Ulcer; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Time Factors; Tosyl Compounds; Tumor Necrosis Factor-alpha; Up-Regulation; Wound Healing | 2000 |
Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation.
Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line, Transformed; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epitopes, T-Lymphocyte; Hepatitis B e Antigens; Histocompatibility Antigens Class I; HIV Envelope Protein gp160; HIV-1; Humans; Hydrolysis; Leupeptins; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Pepstatins; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes, Cytotoxic | 2000 |
Effect of protease inhibitors on angiotensin-converting enzyme activity in human T-lymphocytes.
Topics: Adult; Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Calpain; Captopril; Cathepsins; Chymotrypsin; Cysteine Proteinase Inhibitors; Humans; Leucine; Leupeptins; Lisinopril; Lymphocyte Activation; Male; Oligopeptides; Peptidyl-Dipeptidase A; Protease Inhibitors; T-Lymphocytes | 2000 |
Suppression of autophagy by ethionine administration in male rat liver in vivo.
Topics: Adenine; Adenosine Triphosphate; Animals; Antimetabolites; Centrifugation, Density Gradient; Cysteine Proteinase Inhibitors; Cytosol; Ethionine; L-Lactate Dehydrogenase; Leupeptins; Liver; Lysosomes; Male; Phagosomes; Rats; Rats, Wistar | 2000 |
Performance of small-scale CHO perfusion cultures using an acoustic cell filtration device for cell retention: characterization of separation efficiency and impact of perfusion on product quality.
Topics: Acoustics; Animals; Blotting, Western; Cell Culture Techniques; Cell Survival; CHO Cells; Cricetinae; Filtration; Leupeptins; Macaca mulatta; Perfusion; Tissue Plasminogen Activator | 2000 |
The mitogenic activity of fibroblast growth factor-1 correlates with its internalization and limited proteolytic processing.
Topics: 3T3 Cells; Animals; Antiviral Agents; Cell Nucleus; Chlorpromazine; Cysteine Proteinase Inhibitors; Cytoplasm; Cytosol; Dopamine Antagonists; Endocytosis; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Filipin; Humans; Leupeptins; Ligands; Mice; Mitogens; Signal Transduction | 2000 |
Involvement of cysteine proteases in bFGF-induced angiogenesis in guinea pig and rat cornea.
Topics: Albumins; Animals; Cornea; Corneal Neovascularization; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Delayed-Action Preparations; Dipeptides; Eye Proteins; Fibroblast Growth Factor 2; Guinea Pigs; Leupeptins; Male; Organ Size; Rats | 2000 |
Fibroblast growth factors are translocated to the nucleus of human endothelial cells in a microtubule- and lysosome-independent pathway.
Topics: Biological Transport, Active; Cell Nucleus; Cells, Cultured; Chloroquine; Colchicine; Cytosol; Endothelium, Vascular; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Fibroblast Growth Factors; Humans; Kinetics; Leupeptins; Lysosomes; Microtubules; Subcellular Fractions | 2000 |
Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.
Topics: Animals; Aprotinin; Atrial Natriuretic Factor; Benzamidines; Catalysis; Cell Line; COS Cells; Cricetinae; Gene Expression; Humans; Leupeptins; Membrane Proteins; Protein Precursors; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Structure-Activity Relationship; Trypsin Inhibitors | 2000 |
Increased activity of calcium leak channels caused by proteolysis near sarcolemmal ruptures.
Topics: Animals; Calcium Channels; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leupeptins; Mice; Muscle, Skeletal; Sarcolemma | 2000 |
Subtilisin increases macromolecular efflux from the oral mucosa.
Topics: Animals; Aprotinin; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Cricetinae; Cyclooxygenase Inhibitors; Cysteine Proteinase Inhibitors; Indomethacin; Leupeptins; Macromolecular Substances; Male; Mesocricetus; Mouth Mucosa; Neurokinin-1 Receptor Antagonists; Serine Proteinase Inhibitors; Subtilisin | 2000 |
[Demonstration of secondary free radicals and the role of calpain in functional changes associated with the myocardial ischemia-reperfusion sequence].
Topics: Animals; Antioxidants; Calcium-Binding Proteins; Calpain; Catalase; Cathepsins; Cyclic N-Oxides; Cysteine Proteinase Inhibitors; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Leupeptins; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrogen Oxides; Oxidative Stress; Phycocyanin; Rats; Rats, Wistar; Spin Labels; Superoxides; Time Factors | 2000 |
Purification and characterization of subtilisin DJ-4 secreted by Bacillus sp. strain DJ-4 screened from Doen-Jang.
Topics: Bacillus; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Fermentation; Fibrinolysis; Food Analysis; Korea; Leupeptins; Molecular Weight; Subtilisins | 2000 |
Changes in the Ca2+-activation characteristics of demembranated rat single muscle fibres after prolonged incubation at room temperature in the presence and absence of DTT and protease inhibitors.
Topics: Adenosine Triphosphatases; Animals; Calcium; Dithiothreitol; Histological Techniques; Leupeptins; Male; Muscle Contraction; Muscle Fibers, Skeletal; Myofibrils; Osmolar Concentration; Pepstatins; Protease Inhibitors; Rats; Rats, Long-Evans; Temperature; Time Factors | 2000 |
Il-1-related cytokine responses of nonimmune skin cells subjected to CEES exposure with and without potential vesicant antagonists.
Topics: Benzimidazoles; Biomarkers; Calmodulin; Cells, Cultured; Cysteine Proteinase Inhibitors; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Irritants; Keratinocytes; Leupeptins; Mustard Gas; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Receptors, Interleukin-1; Receptors, Interleukin-1 Type II; Sialoglycoproteins | 2000 |
[Modulation of T-cell-mediated immune responses by trichosanthin via antigen processing and presentation].
Topics: Antigen Presentation; Antigen-Presenting Cells; Cell Division; Chloroquine; Humans; Leupeptins; T-Lymphocytes; Trichosanthin | 1997 |
A sensitive method to assay the xanthine oxidase activity in primary cultures of cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Antagonists; Fluorometry; Glutamic Acid; Leupeptins; Neurons; Protease Inhibitors; Pterins; Rats; Rats, Wistar; Temperature; Xanthine Oxidase; Xanthopterin | 2000 |
Inhibition of apoptosis in cultured porcine granulosa cells by inhibitors of caspase and serine protease activity.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Membrane; Cysteine Proteinase Inhibitors; DNA Fragmentation; Electrophoresis, Agar Gel; Estradiol; Female; Flow Cytometry; Granulosa Cells; Leucine; Leupeptins; Microscopy, Fluorescence; Phenylmethylsulfonyl Fluoride; Progesterone; Radioimmunoassay; Regression Analysis; Serine Proteinase Inhibitors; Swine; Tosylphenylalanyl Chloromethyl Ketone | 2000 |
Role of calcium-dependent protease(s) in globulization of isolated rat lens cortical fiber cells.
Topics: Aniline Compounds; Animals; Calcium; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fluorescent Dyes; Lens Cortex, Crystalline; Leupeptins; Organelles; Rats; Rats, Sprague-Dawley; Time Factors; Xanthenes | 2001 |
Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+).
Topics: Acridine Orange; Adenine; Animals; Aurothioglucose; Cadmium; Cell Death; Chloroquine; Copper; Endopeptidases; Enzyme Activation; Gentamicins; Leupeptins; Lipid Peroxidation; Liver; Lysosomes; Male; Methylamines; Monensin; Oxidation-Reduction; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2001 |
Mechanisms mediating Porphyromonas gingivalis gingipain RgpA-induced oral mucosa inflammation in vivo.
Topics: Adhesins, Bacterial; Animals; Bradykinin; Capillary Permeability; Catalytic Domain; Cricetinae; Cysteine Endopeptidases; Gingipain Cysteine Endopeptidases; Hemagglutinins; Indomethacin; Leupeptins; Male; Mesocricetus; Mouth Mucosa; Periodontitis; Receptor, Bradykinin B2; Receptors, Bradykinin | 2001 |
Leupeptin-induced appearance of partial fragment of betaine homocysteine methyltransferase during autophagic maturation in rat hepatocytes.
Topics: Animals; Autophagy; Betaine-Homocysteine S-Methyltransferase; Chloroquine; Cytosol; Hepatocytes; In Vitro Techniques; Leupeptins; Lysosomes; Male; Methyltransferases; Molecular Probes; Peptide Fragments; Proton-Translocating ATPases; Rats; Rats, Wistar; Vacuolar Proton-Translocating ATPases | 2001 |
Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease.
Topics: Adhesins, Bacterial; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Gingipain Cysteine Endopeptidases; Hemagglutinins; Histatins; Leupeptins; Matrix Metalloproteinase Inhibitors; Periodontal Diseases; Protease Inhibitors; Salivary Proteins and Peptides | 2001 |
MHC class II presentation of endogenous tumor antigen by cellular vaccines depends on the endocytic pathway but not H2-M.
Topics: Acetylcysteine; Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Neoplasm; Antimalarials; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Coculture Techniques; Cysteine Proteinase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Endocytosis; Endoplasmic Reticulum; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Genes, MHC Class II; Humans; Hybridomas; Leupeptins; Major Histocompatibility Complex; Mice; Muramidase; Plasmids; Primaquine; Protein Synthesis Inhibitors; Protein Transport; Ribonucleases; Transfection; Tumor Cells, Cultured | 2000 |
Salivary histatin 5 is a potent competitive inhibitor of the cysteine proteinase clostripain.
Topics: Amino Acid Sequence; Binding, Competitive; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Histatins; Humans; Kinetics; Leupeptins; Molecular Sequence Data; Salivary Glands; Salivary Proteins and Peptides | 2001 |
Suppression of gingival inflammation induced by Porphyromonas gingivalis in rats by leupeptin.
Topics: Adhesins, Bacterial; Animals; Bacteroidaceae Infections; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Disease Progression; Gingipain Cysteine Endopeptidases; Gingivitis; Hemagglutinins; Leupeptins; Male; Maxilla; Porphyromonas gingivalis; Rats; Rats, Wistar; Virulence | 2001 |
Association between bcl-x(L) and 5-lipoxygenase activating protein (FLAP) levels in IL-3-dependent FL5.12 cells.
Topics: 5-Lipoxygenase-Activating Proteins; bcl-X Protein; Blotting, Northern; Blotting, Western; Carrier Proteins; Caspase Inhibitors; Cells, Cultured; Cloning, Molecular; Enzyme Inhibitors; Hematopoietic Stem Cells; Interleukin-3; Leupeptins; Membrane Proteins; Pepstatins; Phenylmethylsulfonyl Fluoride; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Transfection | 2001 |
Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Aprotinin; Autoantigens; Carrier Proteins; Caspases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Herpesvirus 4, Human; Humans; Hydrolysis; Leucine; Leupeptins; Microfilament Proteins; Molecular Weight; Organ Specificity; Pepstatins; Sjogren's Syndrome; Trans-Activators; Tumor Cells, Cultured; Viral Proteins; Virus Activation | 2001 |
Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells.
Topics: Animals; Baculoviridae; Cell Line; Cysteine Proteinase Inhibitors; Genetic Vectors; Insecta; Leucine; Leupeptins; Recombinant Proteins; Transfection | 2001 |
Kinetic and structural properties of two isoforms of trypsin isolated from the viscera of Japanese anchovy, Engraulis japonicus.
Topics: Amino Acid Sequence; Animals; Antipain; Arginine; Benzoylarginine Nitroanilide; Enzyme Stability; Fishes; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Leupeptins; Molecular Sequence Data; Molecular Weight; Trypsin; Trypsin Inhibitors; Viscera | 2001 |
Biogenesis of lysosomes in marshall cells and in cells of the male reproductive system.
Topics: Ammonium Chloride; Animals; Cathepsin B; Cell Line; Cysteine Proteinase Inhibitors; Endocytosis; Endosomes; Epididymis; Ferritins; Fibroblasts; Glycoproteins; Humans; Immunohistochemistry; Intracellular Membranes; Leupeptins; Lysosomes; Male; Mice; Mice, Transgenic; Sandhoff Disease; Saposins; Tay-Sachs Disease; Testis | 2001 |
NO donors inhibit Leishmania infantum cysteine proteinase activity.
Topics: Animals; Ascorbic Acid; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dithiothreitol; Glutathione; Kinetics; Leishmania infantum; Leupeptins; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitroglycerin; Nitroprusside; Nitroso Compounds; Penicillamine; Protozoan Proteins; S-Nitrosoglutathione | 2001 |
Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments.
Topics: Acetylcysteine; Antimalarials; Cell Line; Chloroquine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endocytosis; Humans; Immunoblotting; Leupeptins; Microscopy, Fluorescence; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Sorting Signals; Protein Subunits; Receptors, Interleukin-2; Recombinant Fusion Proteins; Transfection; Ubiquitins | 2001 |
Heat-induced proteasomic degradation of HSF1 in serum-starved human fibroblasts aging in vitro.
Topics: Cells, Cultured; Cellular Senescence; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Female; Fibroblasts; Heat Shock Transcription Factors; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Binding; Transcription Factors | 2001 |
Studies on the aminopeptidase activities of Porphyromonas gingivalis.
Topics: Adhesins, Bacterial; Aminopeptidases; Anti-Bacterial Agents; Carbon Radioisotopes; Cathepsins; Chromogenic Compounds; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptidyl Peptidase 4; Gingipain Cysteine Endopeptidases; Guanidines; Hemagglutinins; Humans; Hydroxamic Acids; Leucine; Leupeptins; Mutation; Oligopeptides; Peptides; Porphyromonas gingivalis; Protease Inhibitors; Radiopharmaceuticals | 2001 |
Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Adenine; Alcohol Dehydrogenase; Animals; Calpain; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Electrophoresis, Polyacrylamide Gel; Hepatocytes; Leupeptins; Liver; Lysosomes; Male; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitins | 2001 |
Calcium regulation of lysosomal proteolysis in skeletal muscle.
Topics: Animals; Calcimycin; Calcium; Calmodulin; Dopamine Antagonists; Female; Insulin; Ionophores; Leupeptins; Lysosomes; Methylamines; Muscle Proteins; Muscle, Skeletal; Protease Inhibitors; Rats; Trifluoperazine | 1986 |
Electrostatic recognition between enzyme and inhibitor: interaction between papain and leupeptin.
Topics: Binding Sites; Computer Simulation; Cysteine Proteinase Inhibitors; Leupeptins; Macromolecular Substances; Models, Chemical; Models, Molecular; Papain; Protein Binding; Static Electricity | 2001 |
Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : understanding the basis of differential inhibition and the role of water.
Topics: Amino Acid Chloromethyl Ketones; Binding Sites; Chymopapain; Computer Simulation; Cysteine Endopeptidases; Leupeptins; Macromolecular Substances; Plant Proteins; Plants; Protease Inhibitors; Protein Binding; Water | 2001 |
Coaggregation of Porphyromonas gingivalis and Prevotella intermedia.
Topics: Adhesins, Bacterial; alpha-Amylases; Arginine; Bacterial Adhesion; Bacterial Proteins; Cysteine Endopeptidases; Endopeptidase K; Fimbriae Proteins; Gingipain Cysteine Endopeptidases; Hemagglutinins; Hot Temperature; Humans; Lectins; Leupeptins; Lysine; Mutation; Plant Proteins; Porphyromonas gingivalis; Prevotella intermedia; Tosyllysine Chloromethyl Ketone; Trypsin Inhibitors | 2001 |
Human muscle protein degradation in vitro by eosinophil cationic protein (ECP).
Topics: Actinin; Blood Proteins; Cysteine Proteinase Inhibitors; Cytoskeleton; Dose-Response Relationship, Drug; Dystrophin; Eosinophil Granule Proteins; Eosinophils; Fibrinolytic Agents; Heparin; Humans; In Vitro Techniques; Inflammation Mediators; Leupeptins; Muscle Proteins; Myofibrils; Myosin Heavy Chains; Myositis; Pepstatins; Protease Inhibitors; Ribonucleases; Sarcoplasmic Reticulum; Spectrin; Zinc | 2001 |
Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria.
Topics: Animals; Apoptosis; Calcium; Caspase 3; Caspases; Cysteine Endopeptidases; Death Domain Receptor Signaling Adaptor Proteins; DNA-Binding Proteins; Erythrocytes; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Macrophage Activation; Mice; Mitochondria; Models, Biological; Oligopeptides | 2001 |
Internalization and stepwise degradation of heparan sulfate proteoglycans in rat hepatocytes.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Chromatography, Gel; Enzyme Inhibitors; Heparan Sulfate Proteoglycans; Hepatocytes; Leupeptins; Lysosomes; Macrolides; Male; Rats; Subcellular Fractions; Sulfur Radioisotopes; Temperature; Tritium; Vinblastine | 2001 |
Characterization of an important enzymatic component in collagenase that is essential for the effective digestion of the human and porcine pancreas.
Topics: Animals; Antibodies, Monoclonal; Cell Separation; Clostridium; Cysteine Proteinase Inhibitors; Enzyme Stability; Epitopes; Humans; Islets of Langerhans; Islets of Langerhans Transplantation; Leupeptins; Mice; Mice, Inbred BALB C; Microbial Collagenase; Molecular Weight; Pancreas; Swine | 2001 |
Inhibition of mu and delta opioid receptor ligand binding by the peptide aldehyde protease inhibitor, leupeptin.
Topics: Benzomorphans; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Ligands; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Aggregation of human platelets by gingipain-R from Porphyromonas gingivalis cells and membrane vesicles.
Topics: Adhesins, Bacterial; Antithrombin III; Arginine; Blood Platelets; Cell Membrane; Chromatography; Cysteine; Cysteine Endopeptidases; Gingipain Cysteine Endopeptidases; Hemagglutinins; Humans; Leupeptins; Platelet Aggregation; Porphyromonas gingivalis | 2002 |
Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity.
Topics: Animals; Anti-Bacterial Agents; Calpain; Cochlea; Dose-Response Relationship, Drug; Gentamicins; Hair Cells, Auditory; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Leupeptins; Mice; Microscopy, Electron; Organ Culture Techniques; Saccule and Utricle; Semicircular Canals; Vestibule, Labyrinth | 2002 |
Opening of ligand-gated cation channel families by calpain inhibitors.
Topics: Amino Acid Sequence; Animals; Calcium; Calcium Channels; Calcium-Binding Proteins; Calpain; Cell Membrane Permeability; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine Proteinase Inhibitors; Electrophysiology; Ion Channel Gating; Leupeptins; Ligands; Membrane Proteins; Molecular Sequence Data; Patch-Clamp Techniques; Receptors, Drug; Transfection; TRPP Cation Channels | 2002 |
Complexity of agonist- and cyclic AMP-mediated downregulation of the human beta 1-adrenergic receptor: role of internalization, degradation, and mRNA destabilization.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Cricetinae; Cyclic AMP; Down-Regulation; Humans; Isoproterenol; Leupeptins; Molecular Sequence Data; Pepstatins; Protease Inhibitors; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; RNA Stability; RNA, Messenger; Thionucleotides | 2002 |
Stage-specific antimalarial activity of cysteine protease inhibitors.
Topics: Animals; Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Gene Expression Regulation, Developmental; Hemoglobins; Hydrolysis; Leucine; Leupeptins; Plasmodium falciparum; Time Factors | 2002 |
Natural killer-like cells in the sheep: functional characterization and regulation by pregnancy-associated proteins.
Topics: Animals; Antibodies, Monoclonal; Dogs; Endometrium; Epithelial Cells; Female; Humans; Interferon Type I; Killer Cells, Natural; Leupeptins; Lymphocytes; Membrane Glycoproteins; Membrane Proteins; Pepstatins; Perforin; Pore Forming Cytotoxic Proteins; Pregnancy; Pregnancy Proteins; Protease Inhibitors; Serpins; Sheep; Tumor Cells, Cultured | 2002 |
Involvement of proteases in the action of IFN-gamma on WISH cells.
Topics: Amnion; Cell Division; Cell Line; Cell Membrane; DNA Replication; Humans; Interferon-gamma; Leupeptins; Lysine; Pepstatins; Phenylalanine; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors; Subcellular Fractions; Thiorphan; Tosyllysine Chloromethyl Ketone; Trypsin Inhibitor, Bowman-Birk Soybean | 2002 |
Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor.
Topics: Adhesins, Bacterial; Animals; Bacteroidaceae Infections; Cysteine Endopeptidases; Disease Models, Animal; Gingipain Cysteine Endopeptidases; Hemagglutinins; Hemolysis; Humans; Leupeptins; Mice; Mice, Inbred BALB C; Mutation; Pigments, Biological; Porphyromonas gingivalis; Protease Inhibitors; Virulence | 2002 |
Impact of cysteine proteinase inhibition in midgut fluid and oral secretion on fecundity and pollen consumption of western corn rootworm (Diabrotica virgifera virgifera).
Topics: Animals; Coleoptera; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Digestive System; Eating; Female; Fertility; Leucine; Leupeptins; Male; Oligopeptides; Pollen; Zea mays | 2003 |
Involvement of cysteine proteinases in excystment of Paragonimus ohirai metacercariae induced by sodium cholate and A23187.
Topics: Animals; Calcimycin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Ionophores; Leucine; Leupeptins; Paragonimus; Parasitology; Reproduction; Serine Proteinase Inhibitors; Sodium Cholate | 2003 |
Expression, purification, and inhibition of in vitro proteolysis of human AMPD2 (isoform L) recombinant enzymes.
Topics: AMP Deaminase; Baculoviridae; Blotting, Western; Chromatography, Gel; Cross-Linking Reagents; Dimerization; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; Humans; Leupeptins; Peptides; Plasmids; Precipitin Tests; Protein Isoforms; Protein Structure, Tertiary; Recombinant Fusion Proteins; Recombinant Proteins; Temperature; Transfection | 2003 |
The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors.
Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; HIV; HIV Infections; Humans; In Vitro Techniques; Leupeptins; Protease Inhibitors; Virus Replication | 2003 |
Neuroprotection of vestibular sensory cells from gentamicin ototoxicity obtained using nitric oxide synthase inhibitors, reactive oxygen species scavengers, brain-derived neurotrophic factors and calpain inhibitors.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calpain; Cell Survival; Free Radical Scavengers; Gentamicins; Guinea Pigs; Hair Cells, Vestibular; In Vitro Techniques; Leupeptins; Methionine; Microscopy, Fluorescence; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Reactive Oxygen Species | 2003 |
In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1.
Topics: Antioxidants; Calpain; Electron Spin Resonance Spectroscopy; Glycoproteins; Kinetics; Leupeptins; Phycocyanin | 2002 |
Calpain-mediated AQP2 proteolysis in inner medullary collecting duct.
Topics: Animals; Aquaporin 2; Aquaporin 6; Aquaporins; Calcium; Calcium-Binding Proteins; Calpain; Caseins; Cysteine Proteinase Inhibitors; Dextrans; Dihydrotachysterol; Dose-Response Relationship, Drug; Down-Regulation; Endosomes; Flow Cytometry; Immunoblotting; Immunohistochemistry; Kidney Tubules, Collecting; Leupeptins; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Trypsin | 2003 |
Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditions.
Topics: Autophagy; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fibroblasts; Humans; Hydrolysis; Kinetics; Lactones; Leupeptins; Lysosomes; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; Scintillation Counting | 2003 |
A nonintrinsic regional basis for increased infrarenal aortic MMP-9 expression and activity.
Topics: Actins; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Blood Pressure; Chelating Agents; Disease Models, Animal; Edetic Acid; Gelatin; Gelatinases; Heart Rate; Leupeptins; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Models, Cardiovascular; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2003 |
Endostatin induces autophagic cell death in EAhy926 human endothelial cells.
Topics: Acridine Orange; Adenine; Animals; Antineoplastic Agents; Apoptosis; Aprotinin; Blotting, Western; Caspases; Cell Death; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Endostatins; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Flow Cytometry; Glutathione Transferase; Humans; Immunohistochemistry; Leupeptins; Lysosomes; Microscopy, Electron; Microscopy, Phase-Contrast; Oxidative Stress; Reactive Oxygen Species; Recombinant Proteins; Serine; Time Factors | 2003 |
Intracellular expression of CD69 in endometrial and peripheral T cells represents a useful marker in women with recurrent miscarriage: modulation after allogeneic leukocyte immunotherapy.
Topics: Abortion, Habitual; Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Biomarkers; CD3 Complex; Cysteine Proteinase Inhibitors; Cytokines; Endometrium; Female; Flow Cytometry; Follow-Up Studies; Humans; Immunophenotyping; Immunotherapy; Lectins, C-Type; Leupeptins; Lymphocyte Activation; Lymphocyte Transfusion; Male; Pregnancy; T-Lymphocyte Subsets; T-Lymphocytes; Transplantation, Homologous | 2003 |
Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Calpain; Caspase Inhibitors; Cathepsins; Cysteine Proteinase Inhibitors; Gentamicins; Guinea Pigs; Hair Cells, Vestibular; Leupeptins; Oligopeptides; Organ Culture Techniques; Pilot Projects | 2003 |
Differential DNA synthesis in response to activation of protease-activated receptors on cultured guinea-pig tracheal smooth muscle cells.
Topics: Actins; Animals; Cell Division; Cells, Cultured; DNA; Guinea Pigs; Humans; Leupeptins; Muscle, Smooth; Peptides; Protease Inhibitors; Receptor, PAR-1; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Thrombin; Thymidine; Trachea; Tryptases | 2003 |
Increase in epidermal growth factor receptor protein induced in osteoblastic cells after exposure to flow of culture media.
Topics: Bone and Bones; Bone Development; Culture Media, Conditioned; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Leupeptins; Osteoblasts; Peptide Hydrolases; Physical Stimulation; Protease Inhibitors; Protein Transport; Signal Transduction; Stress, Mechanical; Tumor Cells, Cultured; Up-Regulation | 2003 |
The calpain-calpastatin system and the calcium paradox in the isolated perfused pigeon heart.
Topics: Animals; Antipain; Barium; Calcium; Calcium-Binding Proteins; Calpain; Cobalt; Columbidae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylmaleimide; Heart; In Vitro Techniques; Kinetics; Leucine; Leupeptins; Magnesium; Manganese; Molecular Weight; Myocardium; Nickel; Phenylmethylsulfonyl Fluoride; Strontium; Time Factors | 2003 |
Characterization of a new p94-like calpain form in human lymphocytes.
Topics: Calcium; Calpain; Catalysis; Cloning, Molecular; Cysteine Proteinase Inhibitors; DNA, Complementary; Enzyme Activation; Erythrocytes; Humans; Immunoblotting; Isoenzymes; Leupeptins; Lymphocytes; Neutrophils; Sequence Analysis, DNA | 2003 |
Calpain-2 as a target for limiting prostate cancer invasion.
Topics: Animals; Calpain; Cell Movement; Cysteine Proteinase Inhibitors; Down-Regulation; ErbB Receptors; Glycoproteins; Humans; Leupeptins; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Oligonucleotides, Antisense; Prostatic Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2003 |
Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors.
Topics: alpha 1-Antitrypsin; Chymases; Humans; Leupeptins; Lung; Mast Cells; Protease Inhibitors; Serine Endopeptidases; Skin; Tryptases | 2003 |
Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells.
Topics: Amphiregulin; Aprotinin; Dose-Response Relationship, Drug; EGF Family of Proteins; Epithelial Cells; ErbB Receptors; Gene Expression Regulation; Glycoconjugates; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Leupeptins; Mucin 5AC; Mucin-2; Mucins; Protease Inhibitors; Quinazolines; Receptor, PAR-2; Respiratory Mucosa; Respiratory System; Serine Endopeptidases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrphostins | 2004 |
Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2.
Topics: Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; Cloning, Molecular; Cysteine Endopeptidases; Disulfides; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Immunoblotting; Kinetics; Leupeptins; Molecular Sequence Data; Plasmodium; Plasmodium falciparum; Protein Folding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Tyrosine | 2004 |
Interaction of Porphyromonas gingivalis with low-density lipoproteins: implications for a role for periodontitis in atherosclerosis.
Topics: Adhesins, Bacterial; Animals; Apolipoprotein B-100; Apolipoproteins B; Arteriosclerosis; Cell Line; Cell Membrane; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Foam Cells; Gingipain Cysteine Endopeptidases; Hemagglutinins; Humans; Leupeptins; Lipoproteins, LDL; Macrophages; Mice; Periodontitis; Porphyromonas gingivalis; Protein Synthesis Inhibitors; Tosyllysine Chloromethyl Ketone; Vacuoles | 2004 |
Protease inhibitor leupeptin attenuates myocardial stunning in rat heart.
Topics: Animals; Blood Pressure; Calcium; Carbon Dioxide; Cardiac Output; Coronary Circulation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; In Vitro Techniques; Leupeptins; Male; Myocardial Contraction; Myocardial Stunning; Oxygen Consumption; Perfusion; Rats; Rats, Wistar | 2004 |
Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organization.
Topics: Animals; Calcium-Binding Proteins; Calpain; Cell Adhesion; Cell Fusion; Cell Line; Cell Movement; Clone Cells; Cysteine Proteinase Inhibitors; Cytoskeleton; Dipeptides; Dose-Response Relationship, Drug; Glucosidases; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Proteins; Mice; Muscle Fibers, Skeletal; Myoblasts; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides; Phosphoproteins; Stress Fibers | 2004 |
The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma.
Topics: Amino Acid Sequence; Antipain; Epitopes; Humans; Kallikreins; Leupeptins; Molecular Sequence Data; Natriuretic Peptide, Brain; Protease Inhibitors; Serine Proteinase Inhibitors; Substrate Specificity | 2004 |
A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin.
Topics: Adhesins, Bacterial; Agar; Animals; Cysteine Endopeptidases; Gingipain Cysteine Endopeptidases; Hemagglutinins; Horses; Leupeptins; Oxyhemoglobins; Pigments, Biological; Porphyromonas gingivalis; Protoporphyrins; Spectrophotometry, Ultraviolet; Spectroscopy, Mossbauer; Spectrum Analysis, Raman; Time Factors | 2004 |
Partial and delayed release of troponin-I compared with the release of lactate dehydrogenase from necrotic cardiomyocytes.
Topics: Animals; Antimetabolites; Calpain; Cysteine Proteinase Inhibitors; Deoxyglucose; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; In Vitro Techniques; L-Lactate Dehydrogenase; Leupeptins; Male; Myocytes, Cardiac; Necrosis; Rats; Rats, Wistar; Sodium Cyanide; Troponin I | 2004 |
Structural basis of the unusual stability and substrate specificity of ervatamin C, a plant cysteine protease from Ervatamia coronaria.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Stability; Evolution, Molecular; Leupeptins; Molecular Sequence Data; Papain; Plant Proteins; Protein Folding; Protein Structure, Tertiary; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Substrate Specificity; Tabernaemontana | 2004 |
Calpain and caspase-3 inhibitors reduce infarct size and post-ischemic apoptosis in rat heart without modifying contractile recovery.
Topics: Animals; Apoptosis; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Glycoproteins; Heart; Ischemia; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Muscle Contraction; Myocardium; Rats; Reperfusion | 2003 |
Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calpain; Cell Count; Cell Survival; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agents; Female; Immunohistochemistry; Isometric Contraction; Leupeptins; Male; Microtubule-Associated Proteins; Motor Neuron Disease; Motor Neurons; Muscle Fatigue; Muscle Fibers, Skeletal; Muscle, Skeletal; Myosins; Nerve Crush; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Spinal Cord; Staining and Labeling; Time Factors | 2004 |
Sustained-release delivery of leupeptin in the chinchilla: hearing results.
Topics: Animals; Auditory Threshold; Calpain; Chinchilla; Cysteine Proteinase Inhibitors; Delayed-Action Preparations; Dose-Response Relationship, Drug; Ear, Inner; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Leupeptins; Models, Animal; Perilymph; Time Factors | 2003 |
Loss of lipopolysaccharide receptor CD14 from the surface of human macrophage-like cells mediated by Porphyromonas gingivalis outer membrane vesicles.
Topics: Adhesins, Bacterial; Blotting, Western; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Escherichia coli; Gingipain Cysteine Endopeptidases; Gingival Crevicular Fluid; Hemagglutinins; Humans; Leupeptins; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophages; Periodontitis; Porphyromonas gingivalis; Tumor Necrosis Factor-alpha; Virulence Factors | 2004 |
[Effects of protease inhibitors on intestinal absorption of insulin].
Topics: Animals; Bacitracin; Biological Availability; Blood Glucose; Colon; Glycocholic Acid; Insulin; Intestinal Absorption; Intestine, Small; Leupeptins; Male; Protease Inhibitors; Random Allocation; Rats; Rats, Wistar | 2004 |
Calpain inhibitors improve myocardial dysfunction and inflammation induced by endotoxin in rats.
Topics: Animals; Cardiomyopathies; Endotoxins; Glycoproteins; Heart; In Vitro Techniques; Inflammation; Injections, Intravenous; Leukocyte Rolling; Leupeptins; Male; Myocardial Contraction; Myocardium; Nitrates; Nitrites; Rats; Rats, Sprague-Dawley; Shock, Septic; Tumor Necrosis Factor-alpha | 2004 |
The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic-reperfused heart.
Topics: Animals; Blotting, Western; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Calpain; Calsequestrin; Cyclic AMP-Dependent Protein Kinases; Cytosol; Down-Regulation; Leupeptins; Male; Myocardial Contraction; Myocardium; Perfusion; Phosphorylation; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Time Factors | 2004 |
Multiple cleavage sites for polymeric immunoglobulin receptor.
Topics: Animals; Cells, Cultured; Cricetinae; Endoplasmic Reticulum; Golgi Apparatus; Humans; Leupeptins; Mutagenesis, Site-Directed; Receptors, Polymeric Immunoglobulin; Secretory Component; Structure-Activity Relationship; Transfection; Vaccinia virus | 2004 |
Myosin Va is proteolysed in rat cerebellar granule neurons after excitotoxic injury.
Topics: Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Cell Death; Cells, Cultured; Cerebellum; Cysteine Proteinase Inhibitors; Drug Interactions; Excitatory Amino Acids; Glycoproteins; Leupeptins; Myosin Heavy Chains; Myosin Type V; Neurons; Rats; Tetrazolium Salts; Thiazoles; Time Factors | 2004 |
The function of a trypsin-like enzyme in the saliva of Euplectrus separatae larvae.
Topics: Animals; Dose-Response Relationship, Drug; Endopeptidase Clp; Host-Parasite Interactions; Hyaluronoglucosaminidase; Larva; Leupeptins; Matrix Metalloproteinases; Moths; Phospholipases; Saliva; Spectrometry, Fluorescence; Trypsin; Trypsin Inhibitors; Wasps | 2004 |
Substrate-dependent modulation of the mechanism of factor XIa inhibition.
Topics: Aprotinin; Binding Sites; Enzyme-Linked Immunosorbent Assay; Factor IX; Factor XIa; Leupeptins; Models, Biological; Protease Inhibitors | 2004 |
Regulation of muscle Cav1.1 channels by long-term depolarization involves proteolysis of the alpha1s subunit.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Leupeptins; Membrane Potentials; Muscle, Skeletal; Patch-Clamp Techniques; Protease Inhibitors; Protein Subunits; Ranidae; RNA, Messenger | 2004 |
Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site.
Topics: Amino Acid Sequence; Animals; Calpain; Catalytic Domain; Cathepsin K; Cathepsins; Crystallization; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Glycoproteins; Leucine; Leupeptins; Molecular Sequence Data; Papain; Protein Structure, Tertiary; Rats | 2004 |
Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis.
Topics: Animals; Antipain; Chromogenic Compounds; Escherichia coli; Fluorescent Dyes; Hydrogen-Ion Concentration; Ixodidae; Leucine; Leupeptins; Pepstatins; Phenylmethylsulfonyl Fluoride; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Temperature | 2004 |
[Effect of tryptase inhibitors on histamine release from human colon mast cells].
Topics: Cells, Cultured; Colon; Histamine Release; Humans; Lactoferrin; Leupeptins; Mast Cells; Protamines; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tryptases | 2004 |
Transferrin-oligomers as potential carriers in anticancer drug delivery.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Drug Carriers; Drug Delivery Systems; Endocytosis; Humans; Indicators and Reagents; Leupeptins; Methotrexate; Polymers; Receptors, Cell Surface; Receptors, Transferrin; Transferrin | 2004 |
Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway.
Topics: Animals; Binding Sites; Blotting, Northern; Blotting, Western; Cell Line; Cholera Toxin; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Enzyme Activation; Fibrinolysin; Flavonoids; Genes, Dominant; Humans; Immediate-Early Proteins; Leupeptins; Lysine; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Plasminogen; Protein Binding; Proto-Oncogene Proteins c-fos; RNA; RNA, Messenger; Serine Endopeptidases; Signal Transduction; Time Factors; Transcription Factors | 2005 |
The interaction of human tryptase-beta with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease.
Topics: Aprotinin; Binding, Competitive; Chromatography, Gel; Enzyme Reactivators; Enzyme Stability; Humans; Hydrogen-Ion Concentration; Hydrolysis; Leupeptins; Protein Structure, Quaternary; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfones; Tryptases | 2005 |
Schistosoma mansoni: functional proteasomes are required for development in the vertebrate host.
Topics: Adenosine Triphosphate; Animals; Biomphalaria; Coumarins; Host-Parasite Interactions; Hydrolysis; Leupeptins; Lung; Mice; Mice, Inbred BALB C; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Schistosoma mansoni; Schistosomiasis mansoni; Ubiquitin | 2005 |
Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Alkaloids; Blotting, Western; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Cytosol; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Green Fluorescent Proteins; Humans; Immunoprecipitation; Leupeptins; Long QT Syndrome; Mutation; Potassium Channels; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ribonucleases; Subcellular Fractions; Time Factors; Transfection; Ubiquitin | 2005 |
A cysteine-activated protease isolated from Todarodes pacificus squid degrades collagen below its denaturation temperature.
Topics: Amino Acid Sequence; Animals; Cattle; Collagen; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Decapodiformes; Hydrogen-Ion Concentration; Leucine; Leupeptins; Molecular Sequence Data; Molecular Weight; Muscles; Octopodiformes; Protein Denaturation; Snails; Species Specificity; Temperature | 2004 |
Induction of cell death in rat small intestine by ischemia reperfusion: differential roles of Fas/Fas ligand and Bcl-2/Bax systems depending upon cell types.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase Inhibitors; Caspases; Cytochromes c; Fas Ligand Protein; Immunohistochemistry; In Situ Nick-End Labeling; Intestine, Small; Leupeptins; Membrane Glycoproteins; Microscopy, Electron; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reperfusion Injury | 2005 |
Alpha-synuclein-positive structures induced in leupeptin-infused rats.
Topics: alpha-Synuclein; Animals; Cysteine Proteinase Inhibitors; Fornix, Brain; Hippocampus; Infusion Pumps, Implantable; Injections, Intraventricular; Leupeptins; Nerve Tissue Proteins; Neurons; Rats; Rats, Wistar; Secretory Vesicles; Synucleins | 2005 |
Testing the "garbage" accumulation theory of ageing: mitotic activity protects cells from death induced by inhibition of autophagy.
Topics: Adenine; Aging; Astrocytes; Autophagy; Cell Line; Cell Survival; Cellular Senescence; Cysteine Proteinase Inhibitors; Fibroblasts; Humans; Leupeptins; Mitosis; Phosphoinositide-3 Kinase Inhibitors | 2005 |
Transient expression of polymeric immunoglobulin receptor in human adenocarcinoma cell line HT-29.
Topics: Culture Media; Cysteine Proteinase Inhibitors; Enzyme-Linked Immunosorbent Assay; HT29 Cells; Humans; Immunoprecipitation; Leupeptins; Protein Kinase C; Protein Transport; Receptors, Polymeric Immunoglobulin; Secretory Component; Tetradecanoylphorbol Acetate; Transfection; Vaccinia virus | 2005 |
B-domain deleted factor VIII is aggregated and degraded through proteasomal and lysosomal pathways.
Topics: Animals; Antigens, CD; Centrifugation, Density Gradient; CHO Cells; Cricetinae; Detergents; Factor VIII; Furin; Glycosylation; Immunoblotting; Immunoprecipitation; Leupeptins; Lysosomal Membrane Proteins; Lysosomes; Microscopy, Confocal; Microscopy, Fluorescence; Neuraminidase; Octoxynol; Peptide Fragments; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Sucrose; Transfection; Tunicamycin | 2005 |
Leupeptin-sensitive proteases involved in cell survival after X-ray irradiation in human RSa cells.
Topics: Apoptosis; Blotting, Western; Cell Division; Cell Survival; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; Fibrinolysis; Flow Cytometry; G2 Phase; Humans; Leupeptins; Peptide Hydrolases; Radiation Tolerance; Tumor Cells, Cultured; X-Rays | 2005 |
Plasmodium berghei: effect of protease inhibitors during gametogenesis and early zygote development.
Topics: Analysis of Variance; Animals; Gametogenesis; Leupeptins; Mice; Mice, Inbred BALB C; Phenanthrolines; Phenylmethylsulfonyl Fluoride; Plasmodium berghei; Protease Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Zygote | 2005 |
Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway.
Topics: Aged; Bronchi; Butadienes; Calcium; Cell Proliferation; Chromatography, Gel; DNA; Fibroblasts; Humans; Leupeptins; Lung; MAP Kinase Signaling System; Middle Aged; Nitriles; Receptor, PAR-2; Serine Endopeptidases; Sputum; Tryptases | 2006 |
Arginine vasopressin transport and metabolism in the pigmented rabbit conjunctiva.
Topics: Animals; Arginine Vasopressin; Biological Transport; Chromatography, High Pressure Liquid; Conjunctiva; Esters; Gabexate; Guanidines; In Vitro Techniques; Leupeptins; Male; Protease Inhibitors; Rabbits; Tritium | 1998 |
Enzymatic measurement of tryptase-like protease release from isolated perfused guinea pig heart during ischemia-reperfusion.
Topics: Animals; Creatine Kinase; Cysteine Proteinase Inhibitors; Female; Guinea Pigs; Histamine Release; In Vitro Techniques; Leupeptins; Myocardial Reperfusion Injury; Myocardium; Serine Endopeptidases; Tryptases | 2005 |
Tryptase increases proliferative activity of human conjunctival fibroblasts through protease-activated receptor-2.
Topics: Benzamidines; Blotting, Western; Cell Proliferation; Cells, Cultured; Conjunctiva; Dose-Response Relationship, Drug; Fibroblasts; Humans; Immunoenzyme Techniques; Keratoconjunctivitis; Leupeptins; Mast Cells; Oligopeptides; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Serine Proteinase Inhibitors; Tryptases; Up-Regulation | 2005 |
Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion.
Topics: Animals; Antibodies, Protozoan; Antipain; Cell Division; Cells, Cultured; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Flow Cytometry; Heteroptera; Immunohistochemistry; Iodoacetamide; Leucine; Leupeptins; Membrane Proteins; Microscopy, Electron; Octoxynol; Plant Proteins; Polyethylene Glycols; Protozoan Proteins; Salivary Glands; Trypanosomatina | 2006 |
High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection.
Topics: Cathepsin B; Chromatography, Liquid; Dipeptides; Drug Stability; Hot Temperature; Leucine; Leupeptins; Online Systems; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tea | 2005 |
Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice.
Topics: Animals; Antibodies; Antipruritics; Benzamidines; Dose-Response Relationship, Drug; Extravasation of Diagnostic and Therapeutic Materials; Guanidines; Histamine; Histamine H1 Antagonists; Injections, Intradermal; Leupeptins; Male; Mast Cells; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Oligopeptides; p-Methoxy-N-methylphenethylamine; Pruritus; Receptor, PAR-2; Serine Endopeptidases; Serotonin; Skin; Terfenadine; Time Factors; Tryptases | 2006 |
X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Humans; Isoenzymes; Leupeptins; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Quaternary; Recombinant Proteins; Sequence Alignment; Serine Endopeptidases; Tryptases | 2006 |
Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities.
Topics: Asthma; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Chemokines, CC; Chemotaxis; Eosinophils; Gene Expression Regulation; Humans; Leupeptins; Mast Cells; Recombinant Proteins; RNA, Messenger; Serine Endopeptidases; Tryptases | 2006 |
Release of iron from ferritin requires lysosomal activity.
Topics: Animals; Caco-2 Cells; Chloroquine; Deferoxamine; Enterocytes; Erythroid Cells; Ferritins; Hepatocytes; Humans; Immunoelectrophoresis; Iron; K562 Cells; Leupeptins; Lysosomes; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Rats | 2006 |
Remodeling of connexin 43 in the diabetic rat heart.
Topics: Animals; Cell Communication; Connexin 43; Diabetes Mellitus, Experimental; Electrophysiology; Gap Junctions; Heart; Immunoblotting; Immunohistochemistry; Leupeptins; Male; Microscopy, Electron; Myocardium; Phosphorylation; Protein Isoforms; Protein Kinase C; Rats; Rats, Wistar; Streptozocin | 2006 |
Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Apoptosis; Biomarkers; Calpain; Cell Survival; Cochlea; Dose-Response Relationship, Drug; Drug Antagonism; Hair Cells, Auditory, Inner; Leupeptins; Mice; Mice, Inbred C57BL; Neomycin; Organ Culture Techniques; Phalloidine; Protein Synthesis Inhibitors | 2006 |
Calpain inhibitors delay injury-induced apoptosis in adult mouse spinal cord motor neurons.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Calpain; Caspases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Female; Glycoproteins; Immunohistochemistry; Leupeptins; Mice; Motor Neurons; Nerve Degeneration; Organ Culture Techniques; Spinal Cord; Spinal Cord Injuries; Time Factors | 2006 |
Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4.
Topics: Adenosine Triphosphatases; Animals; ATPases Associated with Diverse Cellular Activities; Carrier Proteins; Cells, Cultured; Chlorocebus aethiops; Cholesterol; COS Cells; Endosomal Sorting Complexes Required for Transport; Endosomes; Fibroblasts; Glycoproteins; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Glycoproteins; Mutant Proteins; Niemann-Pick C1 Protein; Protein Binding; Protein Processing, Post-Translational; Repressor Proteins; Skin; Ubiquitin; Vesicular Transport Proteins | 2006 |
Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Cysteine Endopeptidases; Enzyme Activation; Escherichia coli; Gene Expression; Glutens; Hordeum; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Molecular Sequence Data; Pepsin A; Protein Folding; Protein Precursors; Protein Structure, Quaternary; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Trypsin | 2006 |
Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase.
Topics: Amino Acid Sequence; Animals; Cathepsin L; Cathepsins; Chromatography, Gel; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; L-Lactate Dehydrogenase; Leucine; Leupeptins; Lysosomes; Male; Molecular Sequence Data; Rats; Rats, Wistar; Sequence Alignment | 2006 |
Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia.
Topics: Animals; Blotting, Western; Cells, Cultured; Cholesterol; Cricetinae; Cricetulus; Cysteine Proteinase Inhibitors; Gene Expression; Immunohistochemistry; Immunoprecipitation; Leupeptins; Membrane Microdomains; Mice; Mice, Neurologic Mutants; Mutant Proteins; Myelin Proteolipid Protein; Nerve Tissue Proteins; Oligodendroglia; Protein Transport; Subcellular Fractions; Time Factors; Transfection | 2006 |
Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogen-induced cholestasis.
Topics: Animals; Aquaporins; Cell Membrane; Cell Membrane Permeability; Cholestasis; Cysteine Proteinase Inhibitors; Down-Regulation; Estradiol; Estrogens; Ethinyl Estradiol; Gene Expression; Hepatocytes; Leupeptins; Liver; Lysosomes; Male; Rats; Rats, Wistar; Water | 2007 |
Synchronization of cell death in a dinoflagellate population is mediated by an excreted thiol protease.
Topics: Age Factors; Animals; Apoptosis; Biological Evolution; Biomass; Carbon Dioxide; Cysteine Endopeptidases; Dinoflagellida; DNA Fragmentation; Hydrogen Peroxide; Leupeptins; Oxidative Stress; Protozoan Proteins; Signal Transduction | 2007 |
Isolation and characterization of a novel acid proteinase, tropiase, from Candida tropicalis IFO 0589.
Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Bromosuccinimide; Candida tropicalis; Caseins; Chromatography; Electrophoresis; Fibrinogen; Guinea Pigs; Hydrolysis; Isoelectric Point; Leupeptins; Molecular Weight | 2007 |
Peptide degradation is a critical determinant for cell-penetrating peptide uptake.
Topics: Androstadienes; Animals; Carrier Proteins; Cell Membrane; Cell-Penetrating Peptides; Chloroquine; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Cytochalasin B; Deoxyglucose; Endocytosis; Leupeptins; Membrane Glycoproteins; Models, Biological; Nocodazole; Oligopeptides; Peptide Fragments; Peptides; Perforin; Phenanthrolines; Phenylmethylsulfonyl Fluoride; Pore Forming Cytotoxic Proteins; Protease Inhibitors; Protein Transport; Sodium Azide; Wortmannin | 2007 |
Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations.
Topics: Acetylcysteine; Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; CHO Cells; Cricetinae; Cricetulus; Fibroblasts; Humans; Leupeptins; Mutation, Missense; Proteasome Inhibitors; Subcellular Fractions | 2007 |
Babesia bovis: effects of cysteine protease inhibitors on in vitro growth.
Topics: Animals; Babesia bovis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Erythrocytes; Leucine; Leupeptins | 2007 |
Endothelial gap junctions are down-regulated by arsenic trioxide.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Line; Connexin 43; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Gap Junctions; Humans; Immunohistochemistry; Leupeptins; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxides; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; von Willebrand Factor | 2007 |
Anthrax protective antigen cleavage and clearance from the blood of mice and rats.
Topics: Animals; Anthrax; Antidotes; Antigens, Bacterial; Bacterial Toxins; Blood; Calcium; Coenzymes; Cysteine Proteinase Inhibitors; Enzyme-Linked Immunosorbent Assay; Leupeptins; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mutation; Peptide Hydrolases; Protein Binding; Rats; Rats, Inbred F344; Survival Analysis | 2007 |
Cloning, site-directed mutagenesis and expression of cathepsin L-like cysteine protease from Uronema marinum (Ciliophora: Scuticociliatida).
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Protozoan; Enzyme Stability; Escherichia coli; Gene Expression; Gene Library; Hydrogen-Ion Concentration; Leucine; Leupeptins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligohymenophorea; Protein Folding; Protozoan Proteins; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 2007 |
Structural basis of the zinc inhibition of human tissue kallikrein 5.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Humans; Kallikreins; Kinetics; Leupeptins; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Substrate Specificity; Zinc | 2007 |
Inhibition of high glucose-induced erythrocyte phosphatidylserine exposure by leupeptin and disaccharides.
Topics: Caspase 3; Caspase 8; Cell Size; Erythrocytes; Freeze Drying; Glucose; Hemolysis; Humans; Leupeptins; Lipid Peroxidation; Phosphatidylserines; Sucrose; Trehalose | 2008 |
Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.
Topics: Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Fluorescent Antibody Technique; Humans; Intracellular Fluid; Leupeptins; Lysosomes; Mice; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Time Factors | 2008 |
Calpain inhibition protects spinal motoneurons from the excitotoxic effects of AMPA in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Calpain; Cysteine Proteinase Inhibitors; Excitatory Amino Acid Agonists; Leupeptins; Male; Motor Neurons; Rats; Rats, Wistar; Rotarod Performance Test; Spinal Cord | 2008 |
Target peptide sequence within infectious human immunodeficiency virus type 1 does not ensure envelope-specific T-helper cell reactivation: influences of cysteine protease and gamma interferon-induced thiol reductase activities.
Topics: Animals; Antigen Presentation; Cysteine Endopeptidases; env Gene Products, Human Immunodeficiency Virus; Erythrocyte Membrane; Histocompatibility Antigens Class II; HIV Infections; HIV-1; Humans; Hybridomas; Interferon-gamma; Interleukin-2; Leupeptins; Lymphocyte Activation; Mice; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; T-Lymphocytes, Helper-Inducer | 2008 |
A novel 51-kDa fragment of the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase formed in the stroma of chloroplasts in dark-induced senescing wheat leaves.
Topics: Chloroplasts; Darkness; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Leupeptins; Pepstatins; Phenanthrolines; Plant Leaves; Protein Subunits; Protons; Ribulose-Bisphosphate Carboxylase; Sulfones; Temperature; Triticum | 2007 |
Endosomal proteases influence the repertoire of MAGE-A3 epitopes recognized in vivo by CD4+ T cells.
Topics: Antigen Presentation; Antigens, Neoplasm; CD4-Positive T-Lymphocytes; Dendritic Cells; Endosomes; Epitopes; Humans; Immunophenotyping; Leukocytes, Mononuclear; Leupeptins; Models, Biological; Neoplasm Proteins; Pepstatins; Peptide Hydrolases; Peptides; Th2 Cells | 2008 |
Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis.
Topics: Benzamidines; Bronchi; Guanidines; Humans; Leupeptins; Myocytes, Smooth Muscle; Oligopeptides; Receptor, PAR-2; Transforming Growth Factor beta; Trypsin Inhibitors; Tryptases | 2008 |
Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons.
Topics: Acetylcysteine; Animals; Blotting, Western; Cysteine Proteinase Inhibitors; Fibroblast Growth Factors; Ganglia, Spinal; Green Fluorescent Proteins; Leupeptins; Ligands; Lysosomes; Neurites; PC12 Cells; Pheochromocytoma; Rats; Receptor, Fibroblast Growth Factor, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Signal Transduction | 2008 |
TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent.
Topics: Animals; Endosomes; Humans; Kinetics; Leupeptins; Lysosomes; Macrolides; Methylamines; Mutation; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Receptor, trkA; Subcellular Fractions; Ubiquitin | 2008 |
Immune-complex assays for tyrosine protein kinases.
Topics: Adenosine Triphosphate; Animals; Aprotinin; Autoradiography; Caseins; Cell Line, Tumor; Electrophoresis, Polyacrylamide Gel; Humans; Immunoprecipitation; Leupeptins; Peptides; Phenylmethylsulfonyl Fluoride; Phosphopyruvate Hydratase; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Sodium Fluoride; Structure-Activity Relationship; Time Factors; Vanadates | 2001 |
Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.
Topics: Animals; Antimalarials; Biological Transport, Active; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Drug Resistance; Erythrocytes; Genes, Protozoan; Humans; In Vitro Techniques; Ion Channels; Leupeptins; Malaria, Falciparum; Plasmodium falciparum; Protozoan Proteins | 2008 |
Role of the calcium-calpain pathway in cytoskeletal damage after eccentric contractions.
Topics: Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Cytoskeleton; Electric Stimulation; Extracellular Space; Immunohistochemistry; In Vitro Techniques; Leupeptins; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Signal Transduction | 2008 |
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apoptosis; Autophagy; Blotting, Western; Brain; Caspase 3; Cysteine Proteinase Inhibitors; Disease Models, Animal; Enzyme Activation; Female; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraventricular; Leupeptins; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Neurons; Receptor Cross-Talk | 2008 |
Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes.
Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Cell Shape; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Leupeptins; Male; Microtubule-Associated Proteins; Myocytes, Cardiac; Necrosis; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Sirolimus; Time Factors; Vacuoles | 2008 |
The periodontal pathogen Porphyromonas gingivalis sensitises human blood platelets to epinephrine.
Topics: Adhesins, Bacterial; Apyrase; Aspirin; Blood Platelets; Calcium Signaling; Cyclooxygenase Inhibitors; Cysteine Endopeptidases; Epinephrine; Gingipain Cysteine Endopeptidases; Humans; In Vitro Techniques; Leupeptins; Nephelometry and Turbidimetry; Oligopeptides; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Porphyromonas gingivalis; Protease Inhibitors; Pyrroles; Quinazolines; Receptors, Proteinase-Activated; Virulence; Yohimbine | 2008 |
Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment.
Topics: Animals; Blotting, Western; Culture Media; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Hemiptera; Hydrogen-Ion Concentration; Leucine; Leupeptins; Microscopy, Fluorescence; Protozoan Proteins; Reducing Agents; Salivary Proteins and Peptides; Solanum lycopersicum; Trypanosomatina | 2008 |
The 2,2',4,4',5,5'-hexachlorobiphenyl-enhanced degradation of connexin 43 involves both proteasomal and lysosomal activities.
Topics: Analysis of Variance; Animals; Cell Communication; Cell Line; Cell Membrane; Connexin 43; Extracellular Signal-Regulated MAP Kinases; Gap Junctions; Leupeptins; Liver; Lysosomes; Metabolic Networks and Pathways; Polychlorinated Biphenyls; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats | 2009 |
Constitutive, agonist-accelerated, recycling and lysosomal degradation of GABA(B) receptors in cortical neurons.
Topics: Animals; Baclofen; Biomarkers; Cell Line; Cells, Cultured; Cerebral Cortex; Clathrin; Cysteine Proteinase Inhibitors; Endocytosis; Endosomes; Female; GABA Agonists; GABA-B Receptor Agonists; Humans; Ionophores; Leupeptins; Lysosomes; Monensin; Neurons; Pregnancy; Rats; Rats, Wistar; Receptors, GABA-B | 2008 |
Calpain-1 is required for hydrogen peroxide-induced myotube atrophy.
Topics: Animals; Calpain; Caspase 3; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Hydrogen Peroxide; Leupeptins; Mice; Muscle Proteins; Muscular Atrophy; Myoblasts, Skeletal; Oxidative Stress; RNA Interference; Sarcomeres; Superoxide Dismutase; Time Factors; Transfection | 2009 |
Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity.
Topics: Animals; Catalytic Domain; Crystallization; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Kinetics; Leupeptins; Models, Molecular; Plasmodium falciparum; Substrate Specificity | 2009 |
G.B. Quan et al., Inhibition of high glucose-induced erythrocyte phosphatidylserine exposure by leupeptin and disaccharides, Cryobiology 56 (1) (2008) 53-61.
Topics: Cell Membrane Permeability; Disaccharides; Erythrocytes; Glucose; Humans; Leupeptins; Lipid Peroxidation; Malondialdehyde; Phosphatidylserines; Thiobarbiturates; Thiobarbituric Acid Reactive Substances | 2009 |
Role of oxidative stress in ischemia-reperfusion-induced alterations in myofibrillar ATPase activities and gene expression in the heart.
Topics: Acetylcysteine; Animals; Antioxidants; Calcium-Transporting ATPases; Cardiac Myosins; Catalase; Enzyme Inhibitors; Gene Expression Regulation; In Vitro Techniques; Leupeptins; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Myofibrils; Myosin Heavy Chains; Myosin Light Chains; Oxidative Stress; Perfusion; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Ventricular Dysfunction, Left; Ventricular Pressure; Xanthine; Xanthine Oxidase | 2009 |
The comparison of parathyroid hormone degradation effect by various protease inhibitors in blood specimen.
Topics: Aprotinin; Blood Specimen Collection; Edetic Acid; Female; Humans; Leucine; Leupeptins; Male; Parathyroid Hormone; Protease Inhibitors; Time Factors | 2009 |
2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells.
Topics: Adherens Junctions; Animals; Axin Protein; beta Catenin; Blotting, Western; Cadherins; Cell Line; Cysteine Proteinase Inhibitors; Epithelial Cells; gamma Catenin; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Leupeptins; Liver; Lysosomes; Phosphorylation; Polychlorinated Biphenyls; Rats; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Transcription, Genetic | 2009 |
HIV-1 integrase-hydrolyzing antibodies from sera of HIV-infected patients.
Topics: Adolescent; Adult; Antibodies, Catalytic; Chromatography, Affinity; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; HIV Infections; HIV Integrase; Humans; Hydrolysis; Leupeptins; Male; Pepstatins; Protease Inhibitors; Sulfones; Young Adult | 2009 |
Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition.
Topics: Animals; Cerebral Cortex; Leupeptins; Lysosomes; Microscopy, Confocal; Neurons; Protein Subunits; Rats; Receptors, GABA-A; Synapses; Ubiquitin | 2009 |
CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization.
Topics: Autophagy; bcl-X Protein; Caspase 8; Caspases; CD11b Antigen; Cell Survival; Chemokine CCL2; Cytokines; Humans; Interleukin-6; Leucine; Leukocytes, Mononuclear; Leupeptins; Lipopolysaccharide Receptors; Macrophages; Monocytes; Proto-Oncogene Proteins c-bcl-2 | 2009 |
Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction.
Topics: Endoplasmic Reticulum; Endoplasmic Reticulum, Smooth; Endosomal Sorting Complexes Required for Transport; Endosomes; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Leupeptins; Lysosomes; Microscopy, Electron; Multivesicular Bodies; Mutation; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; RNA, Small Interfering; Transfection | 2010 |
Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste.
Topics: Animals; Cathepsin L; Cysteine Proteases; Electrophoresis, Polyacrylamide Gel; Fish Products; Fish Proteins; Gels; Hot Temperature; Hydrolysis; Leucine; Leupeptins; Perciformes; Protease Inhibitors | 2010 |
Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit.
Topics: Cell Line; Cytosol; Ferric Compounds; Ferritins; Humans; Iron; Leupeptins; Lysosomes; Mitochondria; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Quaternary Ammonium Compounds | 2010 |
Human B-type natriuretic peptide is not degraded by meprin A.
Topics: Animals; Blood Pressure; Endopeptidases; Humans; Hydrolysis; Kidney; Leupeptins; Metalloendopeptidases; Natriuretic Peptide, Brain; Neprilysin; Peptide Hydrolases; Protease Inhibitors; Rats; Serine Proteases | 2010 |
Collagenolytic activity in sonic extracts of Tannerella forsythia.
Topics: Bacteroides; Calcium Chloride; Cathepsins; Cell Line, Tumor; Chelating Agents; Collagen Type I; Cysteine; Cysteine Proteinase Inhibitors; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Ethylmaleimide; Gelatinases; Humans; Iodoacetamide; Iodoacetic Acid; Leucine; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2010 |
Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia.
Topics: Animals; Cysteine Proteinase Inhibitors; Glutathione; Glutathione Disulfide; Heart Arrest, Induced; Leupeptins; Male; Microscopy, Electron, Transmission; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Time Factors | 2010 |
Leupeptin-based inhibitors do not improve the mdx phenotype.
Topics: Animals; Biomarkers; Calcium-Binding Proteins; Calpain; Creatine Kinase; Cysteine Proteinase Inhibitors; Diaphragm; Disease Models, Animal; Dose-Response Relationship, Drug; Genotype; Leupeptins; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle Strength; Muscular Dystrophy, Duchenne; Necrosis; Phenotype; Proteasome Endopeptidase Complex; Time Factors | 2010 |
Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Biocatalysis; Blotting, Western; Calpain; Catalytic Domain; Cysteine Proteinase Inhibitors; Endosomal Sorting Complexes Required for Transport; Ethylmaleimide; Glutathione Transferase; Green Fluorescent Proteins; HEK293 Cells; Humans; Hydrolysis; Immunoprecipitation; Leucine; Leupeptins; Mutation; Oncogene Proteins; Protein Binding; Recombinant Fusion Proteins; Transfection | 2010 |
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin | 2011 |
A cysteine proteinase in the penetration glands of the cercariae of Cotylurus cornutus (Trematoda, Strigeidae).
Topics: Animals; Cathepsin B; Cercaria; Cysteine Proteases; Cysteine Proteinase Inhibitors; Dithioerythritol; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Ethylmaleimide; Histocytochemistry; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Leupeptins; Trematoda | 2011 |
Induction of IL-13 production and upregulated expression of protease activated receptor-1 by RANTES in a mast cell line.
Topics: Animals; Cell Line; Chemokine CCL5; Flow Cytometry; Humans; Interleukin-12; Interleukin-13; Leupeptins; Mast Cells; Mice; Oligopeptides; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thrombin; Trypsin; Tryptases; Up-Regulation | 2011 |
Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Cathepsins; Cell Line, Tumor; Cells, Cultured; Cysteine Proteinase Inhibitors; Desipramine; Enzyme Inhibitors; Fibroblasts; Fingolimod Hydrochloride; Humans; Hydrolases; Immunosuppressive Agents; Leupeptins; Mice; Neurons; Propylene Glycols; Sphingomyelin Phosphodiesterase; Sphingosine | 2011 |
Intracochlear perfusion of leupeptin and z-VAD-FMK: influence of antiapoptotic agents on gunshot-induced hearing loss.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Cysteine Proteinase Inhibitors; Firearms; Guinea Pigs; Hair Cells, Auditory; Hearing Loss, Noise-Induced; Infusions, Parenteral; Leupeptins; Time Factors | 2011 |
Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion.
Topics: Cell Fusion; Cell Line; Furin; Gene Expression Regulation, Viral; Humans; Leupeptins; Mutation; Peptide Hydrolases; Severe acute respiratory syndrome-related coronavirus; Trypsin; Virus Internalization | 2011 |
Dendroaspis natriuretic peptide and the designer natriuretic peptide, CD-NP, are resistant to proteolytic inactivation.
Topics: Atrial Natriuretic Factor; Cells, Cultured; Cysteine Proteinase Inhibitors; Elapid Venoms; Glycopeptides; HEK293 Cells; Humans; Hydrolysis; Intercellular Signaling Peptides and Proteins; Kidney; Leupeptins; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Neprilysin; Peptides; Receptors, Atrial Natriuretic Factor; Serine Proteinase Inhibitors | 2011 |
Characterization of macroautophagic flux in vivo using a leupeptin-based assay.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Dose-Response Relationship, Drug; Heterozygote; Homeostasis; Lactosylceramides; Leupeptins; Liver; Lysosomes; Male; Mice; Mice, Inbred C57BL; Spleen; Time Factors; Tissue Distribution | 2011 |
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
Topics: Amino Acid Sequence; Ammonia; Animals; Autophagy; Betaine-Homocysteine S-Methyltransferase; Cell Survival; Cysteine Endopeptidases; Hepatocytes; Humans; L-Lactate Dehydrogenase; Leupeptins; Lysosomes; Male; Mass Spectrometry; Models, Biological; Molecular Sequence Data; Peptide Fragments; Proteolysis; Rats; Rats, Wistar; Sequence Analysis, Protein; Time Factors | 2011 |
Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells.
Topics: Amino Acid Sequence; Crosses, Genetic; Erythrocytes; High-Throughput Screening Assays; Humans; Ion Channels; Leupeptins; Molecular Sequence Data; Mutation; Permeability; Plasmodium falciparum; Protozoan Proteins; Sequence Alignment | 2011 |
Porphyromonas gingivalis promotes monocyte migration by activating MMP-9.
Topics: Cathepsins; Cell Culture Techniques; Cell Line; Cell Movement; Chemotaxis, Leukocyte; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Precursors; Humans; Leupeptins; Lipopolysaccharide Receptors; Lipopolysaccharides; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Monocytes; Porphyromonas gingivalis; Protease Inhibitors; Tissue Inhibitor of Metalloproteinase-1 | 2012 |
Preliminary study on the effect of caspase-6 and calpain inhibitors on postmortem proteolysis of myofibrillar proteins in chicken breast muscle.
Topics: Animals; Caspase Inhibitors; Chickens; Desmin; Egtazic Acid; Glycoproteins; Leupeptins; Meat; Muscle Proteins; Myofibrils; Oligopeptides; Pectoralis Muscles; Postmortem Changes; Proteolysis; Troponin T | 2012 |
Leupeptin enhances cell surface localization of fibroblast growth factor receptor 1 in adult sensory neurons by increased recycling.
Topics: Animals; Axons; Cell Membrane; Cell Movement; Endocytosis; Fibroblast Growth Factor 2; Ganglia, Spinal; Leupeptins; Lysosomes; Macrolides; Monensin; PC12 Cells; Protein Transport; Rats; Receptor, Fibroblast Growth Factor, Type 1; Sensory Receptor Cells; Signal Transduction | 2012 |
Human salivary cystatin SA exhibits antimicrobial effect against Aggregatibacter actinomycetemcomitans.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Bacterial Adhesion; Cathepsins; Chromatography, Affinity; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Epithelial Cells; Fusobacterium nucleatum; Humans; Immunoglobulin A, Secretory; Kallikreins; Lactoferrin; Leupeptins; Microscopy, Confocal; Mouth Mucosa; Porphyromonas gingivalis; Saliva; Salivary Cystatins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2012 |
Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Calcium; Calcium Ionophores; Calpain; Cycloheximide; Cysteine Proteinase Inhibitors; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Emetine; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Ionomycin; K Cl- Cotransporters; Leupeptins; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Protein Synthesis Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Statistics, Nonparametric; Symporters; Valine | 2012 |
Sorting of the FGF receptor 1 in a human glioma cell line.
Topics: Caveolins; Cell Line, Tumor; Cell Shape; Clathrin; Endocytosis; Endosomes; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Glioma; Humans; Leupeptins; Ligands; Luminescent Proteins; Lysosomal Membrane Proteins; Lysosomes; Phosphorylation; Protein Transport; Receptor, Fibroblast Growth Factor, Type 1; Time Factors; Transfection | 2013 |
Matrix metalloprotease 2-mediated activation of Ca(2+)-ATPase by superoxide radical (O2*-) in plasma membrane of bovine pulmonary vascular smooth muscle.
Topics: Animals; Antipain; Calcium-Transporting ATPases; Cattle; Cell Membrane; Ethylmaleimide; Free Radicals; Hypoxanthine; Leupeptins; Lung; Matrix Metalloproteinase 2; Muscle, Smooth; Muscle, Smooth, Vascular; Oligopeptides; Oxygen; Pepstatins; Phenylmethylsulfonyl Fluoride; Superoxides; Tissue Inhibitor of Metalloproteinase-2; Trypsin Inhibitor, Bowman-Birk Soybean | 2002 |
Altered T-cell responses by the periodontal pathogen Porphyromonas gingivalis.
Topics: Adhesins, Bacterial; Calcium; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Gingipain Cysteine Endopeptidases; Host-Pathogen Interactions; Humans; Interleukin-2; Jurkat Cells; Leupeptins; Luciferases; Microscopy, Confocal; NF-kappa B; Porphyromonas gingivalis; Proteolysis; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Transcription Factor AP-1 | 2012 |
The balance between receptor recycling and trafficking toward lysosomes determines synaptic strength during long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Arabidopsis Proteins; Biophysics; Carrier Proteins; Cysteine Proteinase Inhibitors; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Green Fluorescent Proteins; GTP-Binding Proteins; Hippocampus; Leupeptins; Long-Term Potentiation; Long-Term Synaptic Depression; Lysosomes; Male; N-Methylaspartate; Neurons; Organ Culture Techniques; Protein Transport; Rats; Rats, Wistar; Receptors, AMPA; Statistics, Nonparametric; Synapses; Transfection | 2012 |
Benzodiazepine treatment induces subtype-specific changes in GABA(A) receptor trafficking and decreases synaptic inhibition.
Topics: Animals; Benzodiazepines; Binding Sites; Cell Membrane; Endocytosis; Inhibitory Postsynaptic Potentials; Leupeptins; Neural Inhibition; Neurons; Protein Subunits; Protein Transport; Rats; Receptors, GABA-A; Synapses | 2012 |
Dephosphorylation reduces passage of ovalbumin antigen through intestinal epithelial Caco-2 cell monolayers.
Topics: Alkaline Phosphatase; Animals; Antigens; Caco-2 Cells; Cathepsins; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Female; Humans; Intestinal Mucosa; Leupeptins; Mice; Mice, Inbred Strains; Ovalbumin; Pepstatins; Phosphorylation; Protease Inhibitors | 2013 |
Profiling drug-induced cell death pathways in the zebrafish lateral line.
Topics: Animals; Antioxidants; Benzamidines; Calpain; Caspase Inhibitors; Cell Death; Cells, Cultured; Cisplatin; Cross-Linking Reagents; Gentamicins; Guanidines; Hair Cells, Auditory, Inner; Lateral Line System; Leupeptins; Methionine; Neomycin; Oligopeptides; Protease Inhibitors; Protein Synthesis Inhibitors; Reactive Oxygen Species; Zebrafish | 2013 |
Inhibition of proteolysis in histiotrophic nutrition pathways alters DNA methylation and one-carbon metabolism in the organogenesis-stage rat conceptus.
Topics: Animals; Base Sequence; Carbon; DNA Methylation; Embryo Culture Techniques; Epigenesis, Genetic; Female; Leupeptins; Methionine Adenosyltransferase; Micronutrients; Molecular Sequence Data; Nutritional Physiological Phenomena; Organogenesis; Promoter Regions, Genetic; Proteolysis; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine | 2013 |
Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways.
Topics: Androgens; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Dihydrotestosterone; Humans; Leucine; Leupeptins; Lysosomes; Male; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, Androgen; Transcriptome; Up-Regulation | 2013 |
LL-37 in periodontal health and disease and its susceptibility to degradation by proteinases present in gingival crevicular fluid.
Topics: Adhesins, Bacterial; Adult; Aged; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Cathelicidins; Cysteine Endopeptidases; Cysteine Proteases; Cysteine Proteinase Inhibitors; Dental Plaque; Enzyme-Linked Immunosorbent Assay; Gingipain Cysteine Endopeptidases; Gingival Crevicular Fluid; Humans; Leupeptins; Middle Aged; Peptide Fragments; Periodontitis; Periodontium; Porphyromonas gingivalis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tosyllysine Chloromethyl Ketone | 2013 |
Inhibitory effects of sword bean extract on alveolar bone resorption induced in rats by Porphyromonas gingivalis infection.
Topics: Adhesins, Bacterial; Alveolar Bone Loss; Animals; Bacteroidaceae Infections; Canavalia; Canavanine; Chlorhexidine; Chromatography, High Pressure Liquid; Cystatins; Cysteine Endopeptidases; Disease Progression; Epithelial Cells; Gingipain Cysteine Endopeptidases; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; KB Cells; Leupeptins; Male; Microbial Sensitivity Tests; Mouth Mucosa; Phytotherapy; Plant Extracts; Porphyromonas gingivalis; Rats; Rats, Wistar; Specific Pathogen-Free Organisms | 2014 |
Inhibition of calpains fails to improve regeneration through a peripheral nerve conduit.
Topics: Action Potentials; Animals; Calpain; Cysteine Proteinase Inhibitors; Leupeptins; Male; Muscle, Skeletal; Nerve Regeneration; Neural Conduction; Rats, Sprague-Dawley; Sciatic Nerve | 2014 |
Enhanced rate of degradation of basic proteins by 26S immunoproteasomes.
Topics: Animals; Histones; Hydrolysis; Kinetics; Leupeptins; Molecular Weight; Peptides; Proteasome Endopeptidase Complex; Proteolysis; Rabbits; Trypsin | 2014 |
Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Culture Media; Leupeptins; Lysosomes; Mice, Inbred C57BL; Neurons; Phosphorylation; Primary Cell Culture; Protein Processing, Post-Translational; tau Proteins | 2014 |
Nostosins, Trypsin Inhibitors Isolated from the Terrestrial Cyanobacterium Nostoc sp. Strain FSN.
Topics: Inhibitory Concentration 50; Iran; Leupeptins; Molecular Structure; Nostoc; Oligopeptides; Trypsin Inhibitors | 2014 |
Effects of copper overload in P19 neurons: impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Apoptosis Regulatory Proteins; Calpain; Caspases; Cell Line, Tumor; Chelating Agents; Chromatin; Copper Sulfate; Dizocilpine Maleate; Gene Expression Regulation; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Leupeptins; Mice; Neoplasm Proteins; Neurons; Nifedipine; Oxidation-Reduction; Oxidative Stress; Protease Inhibitors; Protein Kinase Inhibitors; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Teratocarcinoma | 2014 |
Ferritin-stimulated lipid peroxidation, lysosomal leak, and macroautophagy promote lysosomal "metastability" in primary hepatocytes determining in vitro cell survival.
Topics: Adenine; Aldehydes; Animals; Apoptosis; Autophagy; Culture Media, Conditioned; Endocytosis; Epidermal Growth Factor; Female; Ferritins; Glutathione; Glutathione Disulfide; Hepatocytes; Intracellular Membranes; Iron Chelating Agents; Leupeptins; Liver; Lysosomes; Molecular Imaging; Permeability; Primary Cell Culture; Protease Inhibitors; Protein Aggregates; Rats; Rats, Inbred F344 | 2015 |
Autophagic flux determination in vivo and ex vivo.
Topics: Animals; Autophagy; Cerebellum; Leupeptins; Liver; Lysosomes; Mice; Microscopy, Fluorescence; Retina | 2015 |
Comparative response of rat and rabbit conceptuses in vitro to inhibitors of histiotrophic nutrition.
Topics: Animal Nutritional Physiological Phenomena; Animals; Antibodies; Embryo, Mammalian; Embryonic Development; Female; Fetus; Leupeptins; Rabbits; Rats, Sprague-Dawley; Receptors, Cell Surface; Staining and Labeling; Trypan Blue | 2015 |
Affinity screening using competitive binding with fluorine-19 hyperpolarized ligands.
Topics: Benzamidines; Benzylamines; Binding, Competitive; Fluorine; Kinetics; Leupeptins; Ligands; Magnetic Resonance Spectroscopy; Monte Carlo Method; Trypsin | 2015 |
A CLAG3 mutation in an amphipathic transmembrane domain alters malaria parasite nutrient channels and confers leupeptin resistance.
Topics: Amino Acid Sequence; Animals; Biological Transport; Cell Membrane; Computer Simulation; Cysteine Proteinase Inhibitors; Drug Resistance; Gene Expression Regulation; Genome, Protozoan; Leupeptins; Models, Biological; Molecular Sequence Data; Mutation; Plasmodium falciparum; Protein Structure, Tertiary; Protozoan Proteins | 2015 |
Amino acid starvation induced by protease inhibition produces differential alterations in redox status and the thiol proteome in organogenesis-stage rat embryos and visceral yolk sacs.
Topics: Amino Acids; Animals; Culture Media; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Glutathione; Leupeptins; Lysosomes; Organogenesis; Oxidation-Reduction; Protease Inhibitors; Proteolysis; Proteome; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sulfhydryl Compounds; Yolk Sac | 2015 |
Measurement of allergen-specific secretory IgA in stool of neonates, infants and toddlers by protection against degradation of immunoglobulins and allergens.
Topics: Allergens; Child, Preschool; Feces; Humans; Immunoglobulin A, Secretory; Infant; Infant, Newborn; Leupeptins; Phenylmethylsulfonyl Fluoride; Protein Array Analysis; Serine Proteinase Inhibitors | 2015 |
Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus.
Topics: Adolescent; Animals; Autistic Disorder; Brain; Child; Child, Preschool; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Female; Hippocampus; Humans; Immunoglobulin A; In Vitro Techniques; Leupeptins; Long-Term Potentiation; Male; Myelin Basic Protein; Patch-Clamp Techniques; Proteolysis; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2015 |
Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization.
Topics: Botulinum Toxins, Type A; Cell Membrane; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Dynamins; Flumazenil; GABA Agonists; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hydrazones; Immunohistochemistry; Isoxazoles; Leupeptins; Membrane Potentials; Patch-Clamp Techniques; Receptors, GABA-A; Recombinant Proteins; Transfection | 2016 |
The fine tuning of metabolism, autophagy and differentiation during in vitro myogenesis.
Topics: Ammonium Chloride; Animals; Autophagy; Beclin-1; Cell Differentiation; Cells, Cultured; Leupeptins; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Microscopy, Confocal; Microtubule-Associated Proteins; Mitochondria; Multiprotein Complexes; Muscle Fibers, Skeletal; Myoblasts; RNA Interference; RNA, Small Interfering; Satellite Cells, Skeletal Muscle; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2016 |
Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition.
Topics: Biological Transport, Active; Cell Line, Tumor; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lysosomal-Associated Membrane Protein 2; Lysosomes; Neurons; Vitamin B 12 | 2014 |
Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die.
Topics: Acetylcysteine; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Cells, Cultured; Hippocampus; Ischemia; Leupeptins; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Phosphorylation; Rats; RNA Interference; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Gelatin Zymography Using Leupeptin for the Detection of Various Cathepsin L Forms.
Topics: Cathepsin L; Cells, Cultured; Enzyme Assays; Gelatin; Humans; Leupeptins; Lysosomes; Phosphorylation | 2017 |
Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis.
Topics: Animals; Autophagy; Cell Line; Diet, High-Fat; Disease Models, Animal; Humans; Insulin; Leupeptins; Lipolysis; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Palmitic Acid; Pioglitazone; PPAR alpha; PPAR gamma; Triglycerides | 2017 |
Kinetic studies of serine protease inhibitors in simple and rapid 'active barrier' model systems - Diffusion through an inhibitor barrier.
Topics: Antipain; Diffusion; Dose-Response Relationship, Drug; Gelatin; Kinetics; Leupeptins; Models, Biological; Oligopeptides; Particle Size; Peptide Hydrolases; Serine Proteinase Inhibitors; Spectrophotometry; Structure-Activity Relationship; Surface Properties | 2018 |
Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.
Topics: Allosteric Regulation; Allosteric Site; Calcium; Cations, Divalent; Crystallography, X-Ray; Kallikreins; Kinetics; Leupeptins; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Structure, Tertiary; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Zinc | 2018 |
Controlled cortical impact-induced neurodegeneration decreases after administration of the novel calpain-inhibitor Gabadur.
Topics: Animals; Brain; Brain Injuries, Traumatic; Calpain; Disease Models, Animal; Glycoproteins; Leupeptins; Molecular Structure; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Pregabalin; Rats, Sprague-Dawley | 2018 |
Insertion sequence 1 from calpain-3 is functional in calpain-2 as an internal propeptide.
Topics: Calcium; Calcium-Binding Proteins; Calpain; Cysteine Proteinase Inhibitors; DNA Transposable Elements; Isoenzymes; Leucine; Leupeptins; Muscle Proteins; Protein Conformation; Proteolysis; Recombinant Proteins | 2018 |
Autophagosome immunoisolation from GFP-LC3B mouse tissue.
Topics: Animals; Autophagosomes; Biomarkers; Green Fluorescent Proteins; Leupeptins; Mice, Transgenic; Microtubule-Associated Proteins; Organ Specificity | 2019 |
Characterization of PdCP1, a serine carboxypeptidase from Pseudogymnoascus destructans, the causal agent of White-nose Syndrome.
Topics: Animals; Antipain; Ascomycota; Carboxypeptidases; Chiroptera; Leupeptins; Mycoses; Syndrome | 2018 |
Measurement of Bulk Autophagy by a Cargo Sequestration Assay.
Topics: Animals; Autophagosomes; Autophagy; Cell Culture Techniques; Cytosol; Electroporation; Enzyme Assays; Humans; L-Lactate Dehydrogenase; Leupeptins; Lysosomes; Macrolides | 2019 |
Measuring Nonselective and Selective Autophagy in the Liver.
Topics: Animals; Autophagosomes; Autophagy; Centrifugation, Density Gradient; Cysteine Proteases; Cysteine Proteinase Inhibitors; Leupeptins; Liver; Lysosomes; Male; Mice; Mice, Inbred C57BL; Models, Animal; Rats; Rats, Wistar | 2019 |
Analysis of Chaperone-Mediated Autophagy.
Topics: Ammonium Chloride; Animals; Autophagy; Biological Assay; Female; Leupeptins; Liver; Lysosomes; Male; Mice; Mice, Inbred C57BL; Molecular Chaperones; Proteolysis; Rats; Rats, Wistar | 2019 |
Topics: Aprotinin; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Leupeptins; Protein Folding; Protein Processing, Post-Translational; Protein Stability; Proteolysis; RNA Interference; RNA, Small Interfering; S-Nitrosoglutathione; S-Nitrosothiols; Ubiquitin-Protein Ligases; Ubiquitination | 2019 |
Effects of Five Substances with Different Modes of Action on Cathepsin H, C and L Activities in Zebrafish Embryos.
Topics: Animals; Cathepsin C; Cathepsin H; Cathepsin L; Cysteine Proteinase Inhibitors; Embryo, Nonmammalian; Leupeptins; Zebrafish | 2019 |
Thrombin alters the synthesis and processing of CYR61/CCN1 in human corneal stromal fibroblasts and myofibroblasts through multiple distinct mechanisms.
Topics: Alternative Splicing; Cell Differentiation; Corneal Stroma; Culture Media, Conditioned; Cysteine-Rich Protein 61; Fibroblast Growth Factor 2; Fibroblasts; Hirudins; Humans; Leupeptins; Myofibroblasts; Primary Cell Culture; Proteolysis; Pyrroles; Quinazolines; Receptors, Proteinase-Activated; RNA, Messenger; Signal Transduction; Stromal Cells; Thrombin; Transforming Growth Factor beta1 | 2020 |
In vitro effect of a novel protease inhibitor cocktail on Toxoplasma gondii tachyzoites.
Topics: Analysis of Variance; Animals; Aprotinin; Culture Media, Serum-Free; Cysteine Proteinase Inhibitors; Drug Combinations; Hep G2 Cells; Humans; Leucine; Leupeptins; Mice; Microscopy, Electron, Transmission; Organelles; Pilot Projects; Protease Inhibitors; Serine Proteinase Inhibitors; Statistics, Nonparametric; Sulfones; Toxoplasma | 2020 |
Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Autophagy; Cell Death; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Leupeptins; Male; Mice; Mice, Inbred C57BL; Mitochondria; Proteins | 2021 |
Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations.
Topics: Antiviral Agents; Benzamidines; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Esters; Guanidines; Humans; Leupeptins; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; SARS-CoV-2; Serine Endopeptidases | 2021 |
Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs.
Topics: Animals; Chlorocebus aethiops; COVID-19 Drug Treatment; Ecosystem; Humans; Leupeptins; Medicine, Chinese Traditional; SARS-CoV-2; Vero Cells | 2021 |