leupeptin has been researched along with e 64 in 59 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (13.56) | 18.7374 |
| 1990's | 23 (38.98) | 18.2507 |
| 2000's | 20 (33.90) | 29.6817 |
| 2010's | 6 (10.17) | 24.3611 |
| 2020's | 2 (3.39) | 2.80 |
| Authors | Studies |
|---|---|
| Choh, N; Fujisawa, Y; Furuyama, N; Nishimura, A; Nomura, T; Oi, S; Sohda, T; Yasuma, T | 1 |
| Fujita, M; Fusetani, N; Matsunaga, S; Nakao, Y; Van Soest, RW | 1 |
| Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ | 1 |
| Avery, M; Desai, PV; Gut, J; Patny, A; Rosenthal, PJ; Srivastava, A; Tekwani, B | 1 |
| Desai, SA; Fay, MP; Furuya, T; Gluzman, IY; Goldberg, DE; Kambhampati, S; Lisk, G; Pain, M; Su, XZ | 1 |
| Alves, LC; Assis, DM; Camps, I; Doriguetto, AC; Dos Santos, MH; Juliano, MA; Martins, FT; Veloso, MP | 1 |
| Cendic, K; Korde, R; Malhotra, P; Mohmmed, A; Rizzi, L; Romeo, S; Sinha, D; Sundararaman, S; Vaiana, N | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Isobe, N; Kaneko, H; Nakatsuka, I; Saito, K; Yamada, H; Yoshitake, A | 1 |
| Hara, M; Inagaki, C; Omori, K; Otani, H; Zeng, XT | 1 |
| Azuma, M; David, LL; Kadoya, K; Lampi, KJ; Shearer, TR | 1 |
| Bisiau, H; Degand, P; Demeyer, D; Han, KK; Huet, G; Richet, C; Soudan, B; Tetaert, D | 1 |
| Choudhuri, S; Klaassen, CD; McKim, JM | 1 |
| Knops, J; Lieberburg, I; Sinha, S | 1 |
| Jani, JP; Lazo, JS; Mistry, JS; Morris, G; Sebti, SM | 1 |
| Knutson, VP | 1 |
| Nishimura, C; Nishimura, T; Suzuki, H; Tanaka, N | 1 |
| Lasek, RJ; Sahenk, Z | 1 |
| Berlet, HH; Ilzenhöfer, H | 1 |
| Kurita, Y; Nakao, H; Ogawa, H; Takamori, K; Tsuboi, R | 1 |
| Aikawa, M; Leech, JH; McKerrow, JH; Nagasawa, H; Rosenthal, PJ | 1 |
| Ito, M; Katunuma, N; Kominami, E; Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Toshima, K | 1 |
| Iizuka, H; Iwasaki, Y; Konno, H; Yamamoto, H; Yamamoto, T | 1 |
| Beertsen, W; Everts, V; Tigchelaar-Gutter, W | 1 |
| Horii, I; Koyama, J; Nomura, J; Suzuki, Y | 1 |
| Cho, SY; Chung, YB; Joo, IJ; Kang, SY; Kong, Y | 1 |
| Atsma, DE; Bastiaanse, EM; Jerzewski, A; Van der Laarse, A; Van der Valk, LJ | 1 |
| Rosenthal, PJ | 1 |
| Coombs, GH; North, MJ; Scott, DA | 1 |
| Claeys, E; Demeyer, D; Uytterhaegen, L | 1 |
| Kishore, BK; Maldague, P; Montenez, JP; Tulkens, PM | 1 |
| Homma, Y; Ikeuchi, Y; Kim, K; Suzuki, A | 1 |
| Schnellmann, RG; Yang, X | 1 |
| Cummings, NJ; Groves, MR; Jenkins, JA; Pickersgill, RW; Scott, M; Taylor, MA | 1 |
| Hasselgren, PO; Luo, GJ; Wang, JJ; Wang, L | 1 |
| Atkinson, HJ; Brain, P; Glen, DM; Shewry, PR; Urwin, PE; Walker, AJ | 1 |
| Knap, AK; Peppard, JV | 1 |
| Fagard, R; Lijnen, P; Petrov, V | 1 |
| Cooper, BS; Garrett, WM; Guthrie, HD | 1 |
| Hayashi, Y; Inoue, H; Kizu, Y; Mizuno, F; Ono, M; Saito, I; Takada, K; Tsubota, K; Yamada, K; Yanagi, K | 1 |
| Justesen, J; Martensen, PM | 1 |
| Rosenthal, PJ; Semenov, AV; Shenai, BR | 1 |
| Kim, JH; Mullin, CA | 1 |
| Ikeda, T | 1 |
| Beis, I; Gaitanaki, C; Papazafiri, P | 1 |
| Fujisaki, K; Islam, KM; Kamio, T; Miyoshi, T; Tsuji, N | 1 |
| Ebihara, T; Hattori, S; Irie, S; Matsubara, Y; Miura-Yokota, Y | 1 |
| Alviano, CS; Branquinha, MH; d'Avila-Levy, CM; Dias, FA; Elias, CG; Lopes, AH; Pereira, FM; Ribeiro, RO; Santos, AL; Soares, RM; Souto-Padrón, T | 1 |
| Alcaide-Hidalgo, JM; de Boer, AR; Irth, H; Kolkman, J; Krabbe, JG; Lingeman, H; Niessen, WM; van Emde Boas, CN | 1 |
| Alhassan, A; Govind, Y; Igarashi, I; Okubo, K; Yokoyama, N | 1 |
| Ahn, SJ; Chung, JK; Hong, YK; Jang, JH; Jeon, SJ; Kim, KH; Kim, MS; Kim, NY; Lee, HH; Seo, JS | 1 |
| Branquinha, MH; d'Avila-Levy, CM; Dias, FA; Elias, CG; Lopes, AH; Pereira, FM; Santos, AL; Silva, TL | 1 |
| Kim, YS; Kwon, HJ; Lee, HK | 1 |
| Hu, Y; Itoh, Y; Morioka, K | 1 |
| Hayakawa, T; Kawase, N; Kishi, J; Nakamura, H | 1 |
| Maemoto, Y; Maki, M; Osako, Y; Shibata, H; Suzuki, H; Tanaka, R | 1 |
| Bai, B; Jäämaa, S; Laiho, M; Latonen, L; Moore, HM | 1 |
| Campbell, RL; Davies, PL; McCartney, CE; Ye, Q | 1 |
| Arafa, FM; Elkerdany, ED; Elnassery, SM; Mady, RF; Zaki, SA | 1 |
59 other study(ies) available for leupeptin and e 64
| Article | Year |
|---|---|
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption.
Topics: Aldehydes; Animals; Bone and Bones; Bone Resorption; Calcium; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Endopeptidases; Female; Humans; Hydroxyproline; Mice; Mice, Inbred C3H; Naphthalenesulfonates; Organ Culture Techniques; Ovariectomy; Peptides; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Skull; Structure-Activity Relationship | 1998 |
Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis.
Topics: Animals; Cathepsin B; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Magnetic Resonance Spectroscopy; Oligopeptides; Porifera; Spectrometry, Mass, Fast Atom Bombardment; Stereoisomerism | 1999 |
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.
Topics: Animals; Antimalarials; Chalcones; Cysteine Endopeptidases; Globins; Heme; Hemeproteins; Hydrolysis; Malaria; Mice; Phenylurea Compounds; Plasmodium berghei; Plasmodium falciparum; Polymers; Protease Inhibitors; Structure-Activity Relationship | 2005 |
Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory.
Topics: Animals; Antimalarials; Antiparasitic Agents; Binding Sites; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Databases, Factual; Leishmania donovani; Models, Molecular; Plasmodium falciparum; Quantitative Structure-Activity Relationship | 2006 |
Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.
Topics: Animals; Antimalarials; Biological Transport, Active; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Drug Resistance; Erythrocytes; Genes, Protozoan; Humans; In Vitro Techniques; Ion Channels; Leupeptins; Malaria, Falciparum; Plasmodium falciparum; Protozoan Proteins | 2008 |
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
Topics: Benzophenones; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Kinetics; Models, Molecular; Molecular Structure; Serine Proteinase Inhibitors; Spectrum Analysis | 2009 |
Design and synthesis of protein-protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors.
Topics: Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Models, Molecular; Molecular Mimicry; Molecular Structure; Peptides; Plasmodium falciparum; Protein Binding; Stereoisomerism; Structure-Activity Relationship | 2011 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Differences in alpha 2u-globulins increased in male rat kidneys following treatment with several alpha 2u-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type-alpha 2u-globulin.
Topics: Alpha-Globulins; Animals; Chlorobenzenes; Cyclohexanones; Cyclohexenes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Kidney; Leucine; Leupeptins; Limonene; Male; Naphthalenes; Octanes; Rats; Rats, Sprague-Dawley; Terpenes | 1992 |
Different patterns of protein kinase C redistribution mediated by alpha 1-adrenoceptor stimulation and phorbol ester in rat isolated left ventricular papillary muscle.
Topics: Adrenergic alpha-Agonists; Animals; Leucine; Leupeptins; Male; Myocardial Contraction; Papillary Muscles; Phenylephrine; Phorbol 12,13-Dibutyrate; Protease Inhibitors; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1992 |
Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses.
Topics: Amino Acid Sequence; Animals; Calcimycin; Calpain; Cataract; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Culture Techniques; Cysteine Proteinase Inhibitors; Dipeptides; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Lens, Crystalline; Leucine; Leupeptins; Molecular Sequence Data; Rats; Rats, Sprague-Dawley | 1992 |
Characterization of different proteolytic activities in Trypanosoma brucei brucei.
Topics: Amino Acid Sequence; Animals; Chromatography, Affinity; Chromatography, High Pressure Liquid; Dithiothreitol; Endopeptidases; Glycoproteins; Hydrogen-Ion Concentration; Kinetics; Leucine; Leupeptins; Molecular Sequence Data; Protease Inhibitors; Trypanosoma brucei brucei | 1992 |
Role of hepatic lysosomes in the degradation of metallothionein.
Topics: Animals; Cathepsins; Electrophoresis, Polyacrylamide Gel; Leucine; Leupeptins; Liver; Lysosomes; Male; Metallothionein; Pepstatins; Rats; Rats, Inbred Strains | 1992 |
Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate.
Topics: Amyloid beta-Protein Precursor; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leucine; Leupeptins; Molecular Weight; Peptide Fragments; Transfection | 1992 |
Cysteine proteinase inhibitors and bleomycin-sensitive and -resistant cells.
Topics: Bleomycin; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cysteine Proteinase Inhibitors; Drug Resistance; Drug Synergism; Head and Neck Neoplasms; Leucine; Leupeptins; Tumor Cells, Cultured | 1991 |
Proteolytic processing of the insulin receptor beta subunit is associated with insulin-induced receptor down-regulation.
Topics: Animals; Blotting, Western; Cells, Cultured; Chloroquine; Cycloheximide; Cysteine Endopeptidases; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Insulin; Insulin Antagonists; Leucine; Leupeptins; Mice; Peptide Fragments; Receptor, Insulin | 1991 |
Potentiation of the cytotoxicity of peplomycin against Ehrlich ascites carcinoma by bleomycin hydrolase inhibitors.
Topics: Animals; Bleomycin; Carcinoma, Ehrlich Tumor; Cell Survival; Cysteine Endopeptidases; Drug Synergism; Female; Glycoside Hydrolases; Leucine; Leupeptins; Mice; Oligopeptides; Peplomycin | 1987 |
Inhibition of proteolysis blocks anterograde-retrograde conversion of axonally transported vesicles.
Topics: Animals; Axonal Transport; Axons; Leucine; Leupeptins; Male; Microscopy, Electron; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Reference Values; Sciatic Nerve | 1988 |
Elucidation of cathepsin B-like activity associated with extracts of human myelin basic protein.
Topics: 4-Chloromercuribenzenesulfonate; Cathepsin B; Cathepsins; Dithioerythritol; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Leucine; Leupeptins; Myelin Basic Protein; Protease Inhibitors | 1985 |
Differences in induction of lysosomal protease activity by protease inhibitors in B16 melanoma cell lines.
Topics: Acid Phosphatase; Animals; Cathepsin B; Enzyme Induction; Leucine; Leupeptins; Melanoma, Experimental; Mice; Oligopeptides; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Subcellular Fractions; Tumor Cells, Cultured | 1989 |
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
Topics: Animals; Cysteine Endopeptidases; Hemoglobins; Leucine; Leupeptins; Malaria; Microscopy, Electron; Molecular Weight; Plasmodium falciparum; Protease Inhibitors | 1988 |
Involvement of thiol proteases in galactosialidosis.
Topics: beta-Galactosidase; Cathepsin B; Cathepsin H; Cathepsins; Cells, Cultured; Coumarins; Cysteine Endopeptidases; Diazomethane; Dipeptides; Endopeptidases; Fibroblasts; Galactosidases; Humans; Leucine; Leupeptins; Neuraminidase; Protease Inhibitors | 1986 |
Suppression of neurofilament degradation by protease inhibitors in experimental spinal cord injury.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Intermediate Filament Proteins; Leucine; Leupeptins; Male; Nerve Tissue Proteins; Neurofilament Proteins; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Cord Injuries | 1987 |
The digestion of phagocytosed collagen is inhibited by the proteinase inhibitors leupeptin and E-64.
Topics: 2,2'-Dipyridyl; Animals; Ascorbic Acid; Bone and Bones; Collagen; Culture Techniques; Cycloheximide; Cytochalasin B; Fibroblasts; Leucine; Leupeptins; Mice; Microscopy, Electron; Oligopeptides; Phagocytosis; Vacuoles | 1985 |
The role of proteases in stratum corneum: involvement in stratum corneum desquamation.
Topics: Antipain; Aprotinin; Detergents; Endopeptidases; Epidermis; Ethylmaleimide; Humans; Leucine; Leupeptins; Oligopeptides; Pepstatins; Protease Inhibitors; Sunburn | 1994 |
Excystment of Paragonimus westermani metacercariae by endogenous cysteine protease.
Topics: Animals; Chromatography, Ion Exchange; Collagen; Coumarins; Cysteine Endopeptidases; Dipeptides; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Fibronectins; Hydrogen-Ion Concentration; Iodoacetamide; Leucine; Leupeptins; Myosins; Oligopeptides; Pancreatic Elastase; Paragonimus; Temperature; Trypsin | 1995 |
Role of calcium-activated neutral protease (calpain) in cell death in cultured neonatal rat cardiomyocytes during metabolic inhibition.
Topics: Animals; Animals, Newborn; Calcium; Calpain; Cell Death; Cells, Cultured; Chromatography, Affinity; Chromatography, Ion Exchange; Cysteine Proteinase Inhibitors; Enzyme Activation; Leucine; Leupeptins; Myocardium; Protease Inhibitors; Rats; Rats, Wistar | 1995 |
Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites.
Topics: Animals; Antimalarials; Chymotrypsin; Coumarins; Cysteine Proteinase Inhibitors; Dipeptides; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Fluorescent Dyes; Globins; Humans; Hydrolysis; Leucine; Leupeptins; Oligopeptides; Pepstatins; Plasmodium falciparum; Vacuoles | 1995 |
Trichomonas vaginalis: amoeboid and flagellated forms synthesize similar proteinases.
Topics: Animals; Caseins; Culture Media; Cysteine Proteinase Inhibitors; Diazomethane; Endopeptidases; Leucine; Leupeptins; Lipoproteins; Trichomonas vaginalis | 1995 |
Effects of exogenous protease effectors on beef tenderness development and myofibrillar degradation and solubility.
Topics: Animals; Calcimycin; Calcium; Calpain; Cathepsins; Cattle; Cysteine Proteinase Inhibitors; Diazomethane; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Glycoproteins; Leucine; Leupeptins; Male; Meat; Muscle Proteins; Muscles; Octoxynol; Pepstatins; Phenylmethylsulfonyl Fluoride; Postmortem Changes; Solubility | 1994 |
Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts.
Topics: Animals; Cells, Cultured; Cysteine Proteinase Inhibitors; Fibroblasts; Gentamicins; Leucine; Leupeptins; Lysosomes; Phospholipids; Rats | 1994 |
Effect of high hydrostatic pressure on the conversion of alpha-connectin to beta-connectin.
Topics: Animals; Antibodies, Monoclonal; Calcium; Calpain; Connectin; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Hydrostatic Pressure; Leucine; Leupeptins; Molecular Weight; Muscle Proteins; Muscles; Protein Kinases; Rabbits | 1993 |
Proteinases in renal cell death.
Topics: Animals; Anti-Bacterial Agents; Antimycin A; Antipain; Carboxypeptidases; Cathepsin A; Cathepsin B; Cell Death; Coumarins; Cysteine; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endopeptidases; Hydrocarbons, Fluorinated; Hydroquinones; Isocoumarins; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Leucine; Leupeptins; Lysosomes; Membrane Potentials; Pepstatins; Peroxides; Rabbits; Reactive Oxygen Species; Serine Proteinase Inhibitors; tert-Butylhydroperoxide; Tosyllysine Chloromethyl Ketone | 1996 |
The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Cathepsin B; Computer Simulation; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Precursors; Fruit; Hydrogen Bonding; Leucine; Leupeptins; Models, Molecular; Molecular Sequence Data; Mutation; Oligopeptides; Papain; Plant Proteins; Protein Processing, Post-Translational; Protein Structure, Secondary; Sequence Homology, Amino Acid | 1996 |
Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes.
Topics: Adenosine Triphosphate; Animals; Calcium; Calpain; Cathepsin B; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Deoxyglucose; Dexamethasone; Leucine; Leupeptins; Methylamines; Mifepristone; Multienzyme Complexes; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteins; Rats; Tyrosine; Ubiquitins | 1998 |
Transgenic Arabidopsis leaf tissue expressing a modified oryzacystatin shows resistance to the field slug Deroceras reticulatum (Müller).
Topics: Animals; Arabidopsis; Cystatins; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Mollusca; Plant Leaves; Plants, Genetically Modified; Recombinant Proteins | 1999 |
Effect of the selective and non-selective cysteine protease inhibitors on the intracellular processing of interleukin 6 by HEPG2 cells.
Topics: Cathepsin B; Cathepsins; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Interleukin-6; Intracellular Fluid; Iodine Radioisotopes; Isotope Labeling; Ketones; Leucine; Leupeptins; Recombinant Proteins; Time Factors; Tumor Cells, Cultured | 1999 |
Effect of protease inhibitors on angiotensin-converting enzyme activity in human T-lymphocytes.
Topics: Adult; Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Calpain; Captopril; Cathepsins; Chymotrypsin; Cysteine Proteinase Inhibitors; Humans; Leucine; Leupeptins; Lisinopril; Lymphocyte Activation; Male; Oligopeptides; Peptidyl-Dipeptidase A; Protease Inhibitors; T-Lymphocytes | 2000 |
Inhibition of apoptosis in cultured porcine granulosa cells by inhibitors of caspase and serine protease activity.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Membrane; Cysteine Proteinase Inhibitors; DNA Fragmentation; Electrophoresis, Agar Gel; Estradiol; Female; Flow Cytometry; Granulosa Cells; Leucine; Leupeptins; Microscopy, Fluorescence; Phenylmethylsulfonyl Fluoride; Progesterone; Radioimmunoassay; Regression Analysis; Serine Proteinase Inhibitors; Swine; Tosylphenylalanyl Chloromethyl Ketone | 2000 |
Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Aprotinin; Autoantigens; Carrier Proteins; Caspases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Herpesvirus 4, Human; Humans; Hydrolysis; Leucine; Leupeptins; Microfilament Proteins; Molecular Weight; Organ Specificity; Pepstatins; Sjogren's Syndrome; Trans-Activators; Tumor Cells, Cultured; Viral Proteins; Virus Activation | 2001 |
Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells.
Topics: Animals; Baculoviridae; Cell Line; Cysteine Proteinase Inhibitors; Genetic Vectors; Insecta; Leucine; Leupeptins; Recombinant Proteins; Transfection | 2001 |
Stage-specific antimalarial activity of cysteine protease inhibitors.
Topics: Animals; Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Gene Expression Regulation, Developmental; Hemoglobins; Hydrolysis; Leucine; Leupeptins; Plasmodium falciparum; Time Factors | 2002 |
Impact of cysteine proteinase inhibition in midgut fluid and oral secretion on fecundity and pollen consumption of western corn rootworm (Diabrotica virgifera virgifera).
Topics: Animals; Coleoptera; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Digestive System; Eating; Female; Fertility; Leucine; Leupeptins; Male; Oligopeptides; Pollen; Zea mays | 2003 |
Involvement of cysteine proteinases in excystment of Paragonimus ohirai metacercariae induced by sodium cholate and A23187.
Topics: Animals; Calcimycin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Ionophores; Leucine; Leupeptins; Paragonimus; Parasitology; Reproduction; Serine Proteinase Inhibitors; Sodium Cholate | 2003 |
The calpain-calpastatin system and the calcium paradox in the isolated perfused pigeon heart.
Topics: Animals; Antipain; Barium; Calcium; Calcium-Binding Proteins; Calpain; Cobalt; Columbidae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylmaleimide; Heart; In Vitro Techniques; Kinetics; Leucine; Leupeptins; Magnesium; Manganese; Molecular Weight; Myocardium; Nickel; Phenylmethylsulfonyl Fluoride; Strontium; Time Factors | 2003 |
Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis.
Topics: Animals; Antipain; Chromogenic Compounds; Escherichia coli; Fluorescent Dyes; Hydrogen-Ion Concentration; Ixodidae; Leucine; Leupeptins; Pepstatins; Phenylmethylsulfonyl Fluoride; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Temperature | 2004 |
A cysteine-activated protease isolated from Todarodes pacificus squid degrades collagen below its denaturation temperature.
Topics: Amino Acid Sequence; Animals; Cattle; Collagen; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Decapodiformes; Hydrogen-Ion Concentration; Leucine; Leupeptins; Molecular Sequence Data; Molecular Weight; Muscles; Octopodiformes; Protein Denaturation; Snails; Species Specificity; Temperature | 2004 |
Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion.
Topics: Animals; Antibodies, Protozoan; Antipain; Cell Division; Cells, Cultured; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Flow Cytometry; Heteroptera; Immunohistochemistry; Iodoacetamide; Leucine; Leupeptins; Membrane Proteins; Microscopy, Electron; Octoxynol; Plant Proteins; Polyethylene Glycols; Protozoan Proteins; Salivary Glands; Trypanosomatina | 2006 |
High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection.
Topics: Cathepsin B; Chromatography, Liquid; Dipeptides; Drug Stability; Hot Temperature; Leucine; Leupeptins; Online Systems; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tea | 2005 |
Babesia bovis: effects of cysteine protease inhibitors on in vitro growth.
Topics: Animals; Babesia bovis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Erythrocytes; Leucine; Leupeptins | 2007 |
Cloning, site-directed mutagenesis and expression of cathepsin L-like cysteine protease from Uronema marinum (Ciliophora: Scuticociliatida).
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Protozoan; Enzyme Stability; Escherichia coli; Gene Expression; Gene Library; Hydrogen-Ion Concentration; Leucine; Leupeptins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligohymenophorea; Protein Folding; Protozoan Proteins; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 2007 |
Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment.
Topics: Animals; Blotting, Western; Culture Media; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Hemiptera; Hydrogen-Ion Concentration; Leucine; Leupeptins; Microscopy, Fluorescence; Protozoan Proteins; Reducing Agents; Salivary Proteins and Peptides; Solanum lycopersicum; Trypanosomatina | 2008 |
The comparison of parathyroid hormone degradation effect by various protease inhibitors in blood specimen.
Topics: Aprotinin; Blood Specimen Collection; Edetic Acid; Female; Humans; Leucine; Leupeptins; Male; Parathyroid Hormone; Protease Inhibitors; Time Factors | 2009 |
Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste.
Topics: Animals; Cathepsin L; Cysteine Proteases; Electrophoresis, Polyacrylamide Gel; Fish Products; Fish Proteins; Gels; Hot Temperature; Hydrolysis; Leucine; Leupeptins; Perciformes; Protease Inhibitors | 2010 |
Collagenolytic activity in sonic extracts of Tannerella forsythia.
Topics: Bacteroides; Calcium Chloride; Cathepsins; Cell Line, Tumor; Chelating Agents; Collagen Type I; Cysteine; Cysteine Proteinase Inhibitors; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Ethylmaleimide; Gelatinases; Humans; Iodoacetamide; Iodoacetic Acid; Leucine; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2010 |
Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Biocatalysis; Blotting, Western; Calpain; Catalytic Domain; Cysteine Proteinase Inhibitors; Endosomal Sorting Complexes Required for Transport; Ethylmaleimide; Glutathione Transferase; Green Fluorescent Proteins; HEK293 Cells; Humans; Hydrolysis; Immunoprecipitation; Leucine; Leupeptins; Mutation; Oncogene Proteins; Protein Binding; Recombinant Fusion Proteins; Transfection | 2010 |
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin | 2011 |
Insertion sequence 1 from calpain-3 is functional in calpain-2 as an internal propeptide.
Topics: Calcium; Calcium-Binding Proteins; Calpain; Cysteine Proteinase Inhibitors; DNA Transposable Elements; Isoenzymes; Leucine; Leupeptins; Muscle Proteins; Protein Conformation; Proteolysis; Recombinant Proteins | 2018 |
In vitro effect of a novel protease inhibitor cocktail on Toxoplasma gondii tachyzoites.
Topics: Analysis of Variance; Animals; Aprotinin; Culture Media, Serum-Free; Cysteine Proteinase Inhibitors; Drug Combinations; Hep G2 Cells; Humans; Leucine; Leupeptins; Mice; Microscopy, Electron, Transmission; Organelles; Pilot Projects; Protease Inhibitors; Serine Proteinase Inhibitors; Statistics, Nonparametric; Sulfones; Toxoplasma | 2020 |