Page last updated: 2024-08-25

leupeptin and calpain

leupeptin has been researched along with calpain in 95 studies

Research

Studies (95)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (29.47)	18.7374
1990's	34 (35.79)	18.2507
2000's	25 (26.32)	29.6817
2010's	8 (8.42)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Badalamente, MA; Hurst, LC; Stracher, A	3
Azuma, M; David, LL; Kadoya, K; Lampi, KJ; Shearer, TR	1
Kumar, A; Shafiq, S; Stracher, A; Wadgaonkar, R	1
Kenney, DM; Remold-O'Donnell, E; Van Brocklyn, J	1
Bhattacharyya, J; Sayeed, MM; Thompson, K	1
Arai, A; Frank, S; Lee, KS; Lynch, G; Vanderklish, P	1
Hayashi, M; Inomata, M; Ito, H; Kawashima, S; Saito, Y	1
Beermann, ML; Nixon, RA; Shea, TB	1
Olaya, P; Wasserman, M	1
Schlaepfer, WW; Zimmerman, UJ	2
Armstrong, DL; Denny, JB; Ghuman, A; Polan-Curtain, J; Wayner, MJ	1
Mauss, EA; Puszkin, EG; Zucker, MB	1
Arai, A; Kessler, M; Lee, K; Lynch, G	1
Adachi, Y; Hatanaka, M; Lee, WJ; Maki, M; Murachi, T	1
Au, KS; Lee, MF; Siu, YL	1
Ishida, E; Ito, M; Sato, A; Shigeta, S; Takami, Y; Tanabe, F	1
Bradford, H; Colman, RF; Colman, RW; Hu, CJ; Puri, RN; Zhou, FX	1
Hayashi, M; Inomata, M; Kawashima, S; Nakamura, M; Saito, Y	1
Brass, LF; Shattil, SJ	1
Bevers, EM; Comfurius, P; Verhallen, PF; Zwaal, RF	1
Higuchi, N; Kajiwara, Y; Kambayashi, J; Mori, T; Sakon, M; Tanaka, T; Tsujinaka, T	1
Baudry, M; Ivy, G; Larson, J; Lee, J; Lynch, G; Seubert, P; Shahi, K	1
Baudry, M; Ivy, G; Lynch, G; Seubert, P	1
Angelastro, MR; Bey, P; Mehdi, S; Wiseman, JS	1
Au, KS; Hsu, L; Morrison, M	1
Ando, Y; Imamura, S; Kannagi, R; Kitahara, A; Murachi, T; Saji, H; Yamagata, Y	1
Davis, WL; Jones, RG	1
Goris, J; Merlevede, W; Waelkens, E	1
Hincke, MT; Tolnai, S	1
Horecker, BL; Melloni, E; Michetti, M; Pontremoli, S; Sacco, O; Salamino, F; Sparatore, B	1
Kosaki, G; Suzuki, K; Tanoue, K; Yamamoto, K; Yamazaki, H	1
Croall, DE; DeMartino, GN; Morrow, JS	1
Connold, AL; Evers, JV; Vrbová, G	1
Mykles, DL; Skinner, DM	1
Swanson, GJ; Vrbová, G	1
Hatanaka, M; Kannagi, R; Murachi, T; Murakami, T; Yoshimura, N	1
Baudry, M; Lynch, G	1
Roots, BI	1
Imahori, K; Ishiura, S; Kimura, Y; Kubota, S; Suzuki, K; Tsuji, S	1
Gates, RE; King, LE	1
Elliget, KA; Phelps, PC; Trump, BF	1
Hori, M; Inoue, M; Kamada, T; Kusuoka, H; Matsumura, Y	1
Baudry, M; Bi, X; Tocco, G	1
Heilmeyer, LM; Meyer, H; Shoshan-Barmatz, V; Varsanyi, M; Weil, S	1
Henkart, PA; Nakajima, H; Sarin, A	1
Atsma, DE; Bastiaanse, EM; Jerzewski, A; Van der Laarse, A; Van der Valk, LJ	1
Balcerzak, D; Brustis, JJ; Cottin, P; Ducastaing, A; Elamrani, N; Poussard, S; Safwate, A; Soriano, M	1
Claeys, E; Demeyer, D; Uytterhaegen, L	1
Homma, Y; Ikeuchi, Y; Kim, K; Suzuki, A	1
Al, Z; Cohen, CM	1
Haug, LS; Magnusson, A; Ostvold, AC; Walaas, SI	1
Ganguly, B; Schultz, R; Steinhardt, RA; Turner, PR	1
Krieglstein, J; Rami, A	1
Tyc, F; Vrbová, G	1
Morimoto, T; Ogihara, S	1
Balcerzak, D; Brustis, JJ; Cottin, P; Dourdin, N; Ducastaing, A; Elamrani, N; Poussard, S	1
Hasselgren, PO; Luo, GJ; Wang, JJ; Wang, L	1
Ding, D; Salvi, RJ; Shulman, A; Stracher, A; Wang, J	1
Greensmith, L; Harding, DI; Vrbová, G	1
Badalamente, MA; Stracher, A	1
Fagard, R; Lijnen, P; Petrov, V	1
Maupoil, V; Perrin, C; Rochette, L; Vergely, C; Zeller, M	1
Mezey, E; Potter, JJ; Rennie-Tankersley, L	1
Ding, D; Salvi, RJ; Stracher, A	1
Imai, M; Ishibashi, K; Mochizuki, T; Ohki, G; Somlo, S; Suzuki, M	1
Anniko, M; Shimizu, A; Takumida, M; Watanabe, H	1
Perrin, C; Rochette, L; Vergely, C; Zeller, M	1
Baum, MA; Hammond, TG; Harris, HW; Puliyanda, DP; Ward, DT	1
Anniko, M; Shimizu, A; Suzuki, M; Takumida, M	1
Beis, I; Gaitanaki, C; Papazafiri, P	1
De Tullio, R; Melloni, E; Pontremoli, S; Salamino, F; Stifanese, R	1
Lauffenburger, DA; Luo, JH; Mamoune, A; Wells, A	1
Brustis, JJ; Cottin, P; Dargelos, E; Dedieu, S; Grise, F; Mazères, G; Poussard, S	1
Bax, M; Hessel, M; Li, L; van der Laarse, A; van der Linden, I; van der Valk, L	1
Ecarnot-Laubriet, A; Perrin, C; Rochette, L; Vergely, C	1
Greensmith, L; Kieran, D	1
Balough, BJ; Finley, JC; Gottshall, KR; Hoffer, ME; Killian, P; Shulman, A; Wester, D	1
Chohan, PK; Dhalla, NS; Netticadan, T; Singh, RB	1
Campbell, RL; Cuerrier, D; Davies, PL; Moldoveanu, T	1
Futai, K; Hashimoto, T; Matsubara, A; Momiyama, J; Namba, A; Shinkawa, H	1
Kanje, M; Momeni, HR	1
Corona, JC; Tapia, R	1
Allen, DG; Qin, L; Yeung, EW; Yeung, SS; Zhang, BT	1
Judge, AR; McClung, JM; Powers, SK; Talbert, EE	1
Acosta, P; Barton, E; Carver, T; Pendrak, K; Pham, J; Selsby, J; Sweeney, HL; Tian, Z; Zadel, M	1
Maemoto, Y; Maki, M; Osako, Y; Shibata, H; Suzuki, H; Tanaka, R	1
Ahmad, F; Blaesse, P; Kaila, K; Puskarjov, M	1
Coffin, AB; Mamiya, A; Raible, DW; Rubel, EW; Williamson, KL	1
Hausner, T; Hausott, B; Hopf, R; Klimaschewski, L; Márton, G; Marvaldi, L; Nógrádi, A; Pajer, K; Redl, H; Schmidhammer, R	1
Erhardt, J; Jazvinšćak Jembrek, M; Oršolić, N; Radovanović, V; Vlainić, J	1
Chauhan, S; Dugue, R; Goodman, JH; Hassen, GW; Ling, DSF; Michelson, H; Serrano, P; Shulman, A	1
Campbell, RL; Davies, PL; McCartney, CE; Ye, Q	1

Other Studies

95 other study(ies) available for leupeptin and calpain

Article	Year
Recovery after delayed nerve repair: influence of a pharmacologic adjunct in a primate model. Journal of reconstructive microsurgery, 1992, Volume: 8, Issue:5 Topics: Animals; Axons; Calpain; Cebus; Leupeptins; Median Nerve; Muscles; Muscular Atrophy; Nerve Regeneration; Neural Conduction; Time Factors	1992
Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses. Toxicology and applied pharmacology, 1992, Volume: 117, Issue:1 Topics: Amino Acid Sequence; Animals; Calcimycin; Calpain; Cataract; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Culture Techniques; Cysteine Proteinase Inhibitors; Dipeptides; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Lens, Crystalline; Leucine; Leupeptins; Molecular Sequence Data; Rats; Rats, Sprague-Dawley	1992
The effect of protease inhibitors, leupeptin and E64d, on differentiation of C2C12 myoblasts in tissue culture. Cellular and molecular biology, 1992, Volume: 38, Issue:5 Topics: Animals; Calcium; Calpain; Cell Differentiation; Cell Fusion; Culture Techniques; Leucine; Leupeptins; Mice; Muscles; Protease Inhibitors	1992
Effect of platelet calpain on normal T-lymphocyte CD43: hypothesis of events in the Wiskott-Aldrich syndrome. Blood, 1992, Apr-01, Volume: 79, Issue:7 Topics: Antigens, CD; Blood Platelets; Calcium; Calpain; Humans; Immunoblotting; Leukosialin; Leupeptins; Models, Biological; N-Acetylneuraminic Acid; Neuraminidase; Platelet Membrane Glycoproteins; Sialic Acids; Sialoglycoproteins; Substrate Specificity; T-Lymphocytes	1992
Calcium-dependent and calcium-independent protease activities in skeletal muscle during sepsis. Circulatory shock, 1991, Volume: 35, Issue:2 Topics: Animals; Bacteremia; Calcium; Calpain; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Escherichia coli Infections; Leupeptins; Male; Muscles; Rats; Rats, Inbred Strains	1991
Inhibition of proteolysis protects hippocampal neurons from ischemia. Proceedings of the National Academy of Sciences of the United States of America, 1991, Aug-15, Volume: 88, Issue:16 Topics: Animals; Calpain; Cerebral Ventricles; Electrophysiology; Endopeptidases; Evoked Potentials; Gerbillinae; Hippocampus; Hypoxia; Infusions, Parenteral; Ischemic Attack, Transient; Leupeptins; Neurons; Spectrin; Synapses	1991
Activation of intracellular calcium-activated neutral proteinase in erythrocytes and its inhibition by exogenously added inhibitors. Biochimica et biophysica acta, 1991, Sep-24, Volume: 1094, Issue:3 Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blood Proteins; Calcimycin; Calcium; Calpain; Enzyme Activation; Erythrocytes; Female; In Vitro Techniques; Leucine; Leupeptins; Membrane Proteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Rabbits	1991
Multiple proteases regulate neurite outgrowth in NB2a/dl neuroblastoma cells. Journal of neurochemistry, 1991, Volume: 56, Issue:3 Topics: Animals; Axons; Blood; Calpain; Endopeptidases; Hirudins; Leupeptins; Neuroblastoma; Osmolar Concentration; Protease Inhibitors; Thrombin; Tumor Cells, Cultured	1991
Effect of calpain inhibitors on the invasion of human erythrocytes by the parasite Plasmodium falciparum. Biochimica et biophysica acta, 1991, Apr-15, Volume: 1096, Issue:3 Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Erythrocytes; Humans; Leucine; Leupeptins; Oligopeptides; Pepstatins; Plasmodium falciparum	1991
Two-stage autolysis of the catalytic subunit initiates activation of calpain I. Biochimica et biophysica acta, 1991, Jun-24, Volume: 1078, Issue:2 Topics: Amino Acid Sequence; Animals; Calcium; Calcium-Binding Proteins; Calpain; Carbohydrate Sequence; Cattle; Enzyme Activation; Erythrocytes; Leupeptins; Molecular Sequence Data	1991
Calpain inhibitors block long-term potentiation. Brain research, 1990, Nov-26, Volume: 534, Issue:1-2 Topics: Animals; Calpain; Glycoproteins; Hippocampus; In Vitro Techniques; Kinetics; Leupeptins; Neuronal Plasticity; Rats; Rats, Inbred Strains; Synapses	1990
Assembly and GPIIIa content of cytoskeletal core in platelets agglutinated with bovine von Willebrand factor. Blood, 1990, Oct-15, Volume: 76, Issue:8 Topics: Actinin; Actins; Adenosine Diphosphate; Adult; Animals; Blood Platelets; Calpain; Cattle; Cytoskeleton; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Leupeptins; Microfilament Proteins; Molecular Weight; Myosins; Platelet Aggregation; Platelet Membrane Glycoproteins; von Willebrand Factor	1990
Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slices. Brain research, 1990, Nov-05, Volume: 532, Issue:1-2 Topics: Animals; Calpain; Cell Hypoxia; Glycoproteins; Hippocampus; In Vitro Techniques; Leupeptins; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission	1990
Factors influencing the binding of calpain I to human erythrocyte inside-out vesicles. Biochemistry international, 1990, Volume: 22, Issue:1 Topics: Arginase; Calcium; Calcium-Binding Proteins; Calpain; Caseins; Erythrocyte Membrane; Humans; Immunoelectrophoresis; Immunoglobulins; Leupeptins; Models, Biological; Muramidase; Ovalbumin; Protease Inhibitors	1990
Ca2+-mediated activation of human erythrocyte membrane Ca2+-ATPase. Biochimica et biophysica acta, 1989, Jan-30, Volume: 978, Issue:2 Topics: Calcium; Calcium-Transporting ATPases; Calmodulin; Calpain; Erythrocyte Membrane; Glycodeoxycholic Acid; Humans; Kinetics; Leupeptins	1989
The thiol proteinase inhibitors improve the abnormal rapid down-regulation of protein kinase C and the impaired natural killer cell activity in (Chediak-Higashi syndrome) beige mouse. Biochemical and biophysical research communications, 1989, Apr-28, Volume: 160, Issue:2 Topics: Animals; Calpain; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Disease Models, Animal; Killer Cells, Natural; Killer Factors, Yeast; Leucine; Leupeptins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Protein Biosynthesis; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate	1989
Thrombin-induced platelet aggregation involves an indirect proteolytic cleavage of aggregin by calpain. Archives of biochemistry and biophysics, 1989, Volume: 271, Issue:2 Topics: Adenosine; Adenosine Diphosphate; Affinity Labels; Antipain; Blood Platelets; Calpain; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Humans; Leupeptins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protease Inhibitors; Thrombin	1989
Properties of erythrocyte membrane binding and autolytic activation of calcium-activated neutral protease. The Journal of biological chemistry, 1989, Nov-05, Volume: 264, Issue:31 Topics: Animals; Blood Proteins; Calcium; Calcium-Binding Proteins; Calpain; Caseins; Chickens; Egtazic Acid; Enzyme Activation; Erythrocyte Membrane; Immunoblotting; Kinetics; Leupeptins; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Rabbits; Vimentin	1989
Inhibition of thrombin-induced platelet activation by leupeptin. Implications for the participation of calpain in the initiation of platelet activation. The Journal of biological chemistry, 1988, Apr-15, Volume: 263, Issue:11 Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Antipain; Calpain; Dose-Response Relationship, Drug; GTP-Binding Proteins; Humans; Leupeptins; Oligopeptides; Phosphatidic Acids; Phosphatidylinositols; Platelet Aggregation; Thrombin; Virulence Factors, Bordetella	1988
Fluoride-dependent calcium-induced platelet procoagulant activity shows that calpain is involved in increased phospholipid transbilayer movement. Biochimica et biophysica acta, 1988, Jul-07, Volume: 942, Issue:1 Topics: Blood Platelets; Calcium; Calpain; Fluorides; Humans; In Vitro Techniques; Leupeptins; Lipid Bilayers; Membrane Lipids; Membrane Proteins; Motion; Phosphatidylserines; Thromboplastin	1988
Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochemical and biophysical research communications, 1988, Jun-30, Volume: 153, Issue:3 Topics: Animals; Blood Platelets; Calcimycin; Calpain; Cell Membrane Permeability; Dipeptides; Leupeptins; Microfilament Proteins; Papain; Peptides; Swine	1988
Calcium-activated neutral proteases (calpains) are carbohydrate binding proteins. The Journal of biological chemistry, 1988, Aug-25, Volume: 263, Issue:24 Topics: Calcium; Calcium-Binding Proteins; Calpain; Carbohydrate Metabolism; Chromatography; Disaccharides; Enzyme Activation; Ethylene Glycol; Ethylene Glycols; Leupeptins; Octoxynol; Polyethylene Glycols; Sepharose; Thiocyanates; Urea	1988
Lesions of entorhinal cortex produce a calpain-mediated degradation of brain spectrin in dentate gyrus. I. Biochemical studies. Brain research, 1988, Sep-06, Volume: 459, Issue:2 Topics: Animals; Calmodulin; Calpain; Cerebral Cortex; Enzyme Inhibitors; Hippocampus; Injections, Intraventricular; Leupeptins; Male; Molecular Weight; Rats; Rats, Inbred Strains; Spectrin	1988
Lesions of entorhinal cortex produce a calpain-mediated degradation of brain spectrin in dentate gyrus. II. Anatomical studies. Brain research, 1988, Sep-06, Volume: 459, Issue:2 Topics: Animals; Calpain; Cerebral Cortex; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Leupeptins; Male; Nerve Degeneration; Rats; Rats, Inbred Strains; Spectrin; Time Factors	1988
Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain. Biochemical and biophysical research communications, 1988, Dec-30, Volume: 157, Issue:3 Topics: Animals; Blotting, Western; Calcimycin; Calcium; Calpain; Cell Membrane Permeability; Cytoskeletal Proteins; Dipeptides; Erythrocyte Membrane; Hydrolysis; Leupeptins; Membrane Proteins; Molecular Weight; Peptide Hydrolases; Protease Inhibitors; Rats; Spectrin	1988
Ca2+-mediated catabolism of human erythrocyte band 3 protein. Biochimica et biophysica acta, 1988, Dec-08, Volume: 946, Issue:1 Topics: Anion Exchange Protein 1, Erythrocyte; Calcium; Calpain; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Leupeptins; Molecular Weight	1988
Platelet factor XIII is activated by calpain. Biochemical and biophysical research communications, 1987, Apr-14, Volume: 144, Issue:1 Topics: Blood Platelets; Calcium; Calcium-Binding Proteins; Calpain; Enzyme Activation; Factor XIII; Humans; In Vitro Techniques; Leupeptins; Thrombin; Transglutaminases	1987
Leupeptin, a protease inhibitor, blocks insemination-induced flight muscle histolysis in the fire ant Solenopsis. Tissue & cell, 1985, Volume: 17, Issue:1 Topics: Animals; Ants; Atrophy; Calpain; Cytoskeleton; Endopeptidases; Female; Insemination; Leupeptins; Muscle Proteins; Muscles; Oligopeptides; Protease Inhibitors; Wings, Animal	1985
Activation of the PCSM-protein phosphatase by a Ca2+-dependent protease. FEBS letters, 1985, Nov-18, Volume: 192, Issue:2 Topics: Animals; Calpain; Egtazic Acid; Enzyme Activation; Kinetics; Leupeptins; Muscles; Phosphoprotein Phosphatases; Rabbits	1985
Phosphorylation of bovine cardiac calcium-activated neutral protease by protein kinase-C. Biochemical and biophysical research communications, 1986, May-29, Volume: 137, Issue:1 Topics: Animals; Calpain; Cattle; Enzyme Activation; Leupeptins; Macromolecular Substances; Molecular Weight; Myocardium; Phosphorylation; Phosphothreonine; Protein Kinase C	1986
Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring proteinase. The Journal of biological chemistry, 1986, Jun-25, Volume: 261, Issue:18 Topics: Calpain; Cytochalasin B; Endopeptidases; Exocytosis; Humans; Hydrogen Peroxide; Leupeptins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Retinaldehyde; Serine Endopeptidases; Tetradecanoylphorbol Acetate; Trifluoperazine	1986
Cleavage site of calcium-dependent protease in human platelet membrane glycoprotein Ib. Thrombosis research, 1986, Jul-01, Volume: 43, Issue:1 Topics: Animals; Calcimycin; Calcium; Calpain; Chickens; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Humans; Isoelectric Point; Leucine; Leupeptins; Membrane Proteins; Molecular Weight; Phenotype; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins	1986
Limited proteolysis of the erythrocyte membrane skeleton by calcium-dependent proteinases. Biochimica et biophysica acta, 1986, Jul-16, Volume: 882, Issue:3 Topics: Anion Exchange Protein 1, Erythrocyte; Blood Proteins; Calcimycin; Calpain; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Humans; Leupeptins; Membrane Proteins; Mersalyl; Neuropeptides; Spectrin	1986
Effect of low calcium and protease inhibitors on synapse elimination during postnatal development in the rat soleus muscle. Brain research, 1986, Volume: 393, Issue:1 Topics: Animals; Animals, Newborn; Calcium; Calpain; Egtazic Acid; Leupeptins; Mersalyl; Muscle Development; Neuromuscular Junction; Rats; Rats, Inbred Strains	1986
Four Ca2+-dependent proteinase activities isolated from crustacean muscle differ in size, net charge, and sensitivity to Ca2+ and inhibitors. The Journal of biological chemistry, 1986, Jul-25, Volume: 261, Issue:21 Topics: Animals; Calcium; Calcium Channel Blockers; Calpain; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Iodoacetamide; Leupeptins; Molecular Weight; Muscles; Nephropidae; Pepstatins; Phenylmethylsulfonyl Fluoride	1986
Calcium-induced degeneration of the cytoskeleton in monkey and human peripheral nerves. Journal of hand surgery (Edinburgh, Scotland), 1986, Volume: 11, Issue:3 Topics: Animals; Calcium; Calpain; Cebus; Culture Media; Cytoskeleton; Humans; Intermediate Filaments; Leupeptins; Microtubules; Nerve Degeneration; Peripheral Nerves; Wallerian Degeneration	1986
Effects of low calcium and inhibition of calcium-activated neutral protease (CANP) on mature nerve terminal structure in the rat sternocostalis muscle. Brain research, 1987, Volume: 430, Issue:2 Topics: Animals; Calcium; Calpain; Egtazic Acid; Leupeptins; Motor Neurons; Neuromuscular Junction; Neuronal Plasticity; Rats; Rats, Inbred Strains	1987
Evidence for membrane-associated calpain I in human erythrocytes. Detection by an immunoelectrophoretic blotting method using monospecific antibody. Biochemistry, 1984, Jul-03, Volume: 23, Issue:14 Topics: Antibodies, Monoclonal; Calcium; Calcium-Binding Proteins; Calpain; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Erythrocyte Membrane; Humans; Immunoelectrophoresis; Immunoglobulin G; Leupeptins; Protease Inhibitors	1984
The biochemistry of memory: a new and specific hypothesis. Science (New York, N.Y.), 1984, Jun-08, Volume: 224, Issue:4653 Topics: Animals; Calcium; Calpain; Carrier Proteins; Cerebral Cortex; Endopeptidases; Glutamates; Glutamic Acid; Hippocampus; Humans; Learning; Leupeptins; Memory; Microfilament Proteins; Neuronal Plasticity; Rabbits; Rats; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Membranes; Telencephalon	1984
Neurofilament accumulation induced in synapses by leupeptin. Science (New York, N.Y.), 1983, Sep-02, Volume: 221, Issue:4614 Topics: Animals; Axonal Transport; Calpain; Cytoskeleton; Fishes; Leupeptins; Nerve Endings; Neuronal Plasticity; Oligopeptides; Protease Inhibitors; Synapses; Synaptic Transmission	1983
Autolysis of calcium-activated neutral protease of chicken skeletal muscle. Journal of biochemistry, 1981, Volume: 90, Issue:6 Topics: Animals; Calcium; Calpain; Chickens; Edetic Acid; Endopeptidases; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Molecular Weight; Muscles; Peptide Hydrolases; Protease Inhibitors; Temperature	1981
Proteolysis of the epidermal growth factor receptor by endogenous calcium-activated neutral protease from rat liver. Biochemical and biophysical research communications, 1983, May-31, Volume: 113, Issue:1 Topics: Animals; Calpain; Endopeptidases; ErbB Receptors; Leupeptins; Liver; Male; Molecular Weight; Phosphorylation; Rats; Rats, Inbred Strains; Receptors, Cell Surface	1983
Cytosolic Ca2+ elevation and calpain inhibitors in HgCl2 injury to rat kidney proximal tubule epithelial cells. Pathobiology : journal of immunopathology, molecular and cellular biology, 1994, Volume: 62, Issue:5-6 Topics: Animals; Antipain; Calcium; Calpain; Cell Survival; Cells, Cultured; Cytoplasm; Cytosol; Kidney Tubules, Proximal; Leupeptins; Male; Mercuric Chloride; Microscopy, Electron; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Rats	1994
Protective effect of the protease inhibitor leupeptin against myocardial stunning. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:1 Topics: Animals; Calpain; Enzyme Activation; Guinea Pigs; Hemodynamics; In Vitro Techniques; Leupeptins; Male; Myocardial Reperfusion Injury; Protease Inhibitors; Reference Values	1993
Calpain-mediated regulation of AMPA receptors in adult rat brain. Neuroreport, 1994, Dec-30, Volume: 6, Issue:1 Topics: Animals; Brain; Calcium; Calpain; Glycoproteins; Immunohistochemistry; Leupeptins; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Tissue Distribution	1994
Endogenous, Ca(2+)-dependent cysteine-protease cleaves specifically the ryanodine receptor/Ca2+ release channel in skeletal muscle. The Journal of membrane biology, 1994, Volume: 142, Issue:3 Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Calcium; Calcium Channels; Calpain; Cysteine; Dithiothreitol; Iodoacetamide; Leupeptins; Magnesium; Mercaptoethanol; Mercuric Chloride; Molecular Sequence Data; Molecular Weight; Muscle Proteins; Muscle, Skeletal; Rabbits; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sodium Chloride; Substrate Specificity	1994
A protease-dependent TCR-induced death pathway in mature lymphocytes. Journal of immunology (Baltimore, Md. : 1950), 1995, Jun-01, Volume: 154, Issue:11 Topics: Animals; Antibodies, Monoclonal; Apoptosis; Calpain; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Cell Line; Cytotoxicity, Immunologic; Endopeptidases; Leupeptins; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Protease Inhibitors; Receptors, Antigen, T-Cell; T-Lymphocytes; Thymus Gland	1995
Role of calcium-activated neutral protease (calpain) in cell death in cultured neonatal rat cardiomyocytes during metabolic inhibition. Circulation research, 1995, Volume: 76, Issue:6 Topics: Animals; Animals, Newborn; Calcium; Calpain; Cell Death; Cells, Cultured; Chromatography, Affinity; Chromatography, Ion Exchange; Cysteine Proteinase Inhibitors; Enzyme Activation; Leucine; Leupeptins; Myocardium; Protease Inhibitors; Rats; Rats, Wistar	1995
Rat myoblast fusion requires exteriorized m-calpain activity. European journal of cell biology, 1994, Volume: 64, Issue:2 Topics: Animals; Biological Assay; Calcium-Binding Proteins; Calpain; Cell Fusion; Cells, Cultured; Culture Media; Immunoglobulin G; Immunohistochemistry; Kinetics; Leupeptins; Muscle Fibers, Skeletal; Rats; Rats, Wistar	1994
Effects of exogenous protease effectors on beef tenderness development and myofibrillar degradation and solubility. Journal of animal science, 1994, Volume: 72, Issue:5 Topics: Animals; Calcimycin; Calcium; Calpain; Cathepsins; Cattle; Cysteine Proteinase Inhibitors; Diazomethane; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Glycoproteins; Leucine; Leupeptins; Male; Meat; Muscle Proteins; Muscles; Octoxynol; Pepstatins; Phenylmethylsulfonyl Fluoride; Postmortem Changes; Solubility	1994
Effect of high hydrostatic pressure on the conversion of alpha-connectin to beta-connectin. Journal of biochemistry, 1993, Volume: 114, Issue:4 Topics: Animals; Antibodies, Monoclonal; Calcium; Calpain; Connectin; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Hydrostatic Pressure; Leucine; Leupeptins; Molecular Weight; Muscle Proteins; Muscles; Protein Kinases; Rabbits	1993
Phorbol 12-myristate 13-acetate-stimulated phosphorylation of erythrocyte membrane skeletal proteins is blocked by calpain inhibitors: possible role of protein kinase M. The Biochemical journal, 1993, Dec-15, Volume: 296 ( Pt 3) Topics: Amino Acid Sequence; Blood Proteins; Calpain; Down-Regulation; Erythrocyte Membrane; Glycoproteins; Humans; In Vitro Techniques; Leupeptins; Membrane Proteins; Molecular Sequence Data; Phosphorylation; Protease Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate	1993
Calcium-induced degradation of the inositol (1,4,5)-trisphosphate receptor/Ca(2+)-channel. FEBS letters, 1993, Jun-01, Volume: 323, Issue:3 Topics: Animals; Astrocytes; Calcium; Calcium Channels; Calpain; Cell Membrane; Cerebellum; Chromatography, Affinity; Dipeptides; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Leupeptins; Male; Molecular Weight; Neurons; Phosphorylation; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Testis; Tumor Cells, Cultured; Vas Deferens	1993
Proteolysis results in altered leak channel kinetics and elevated free calcium in mdx muscle. The Journal of membrane biology, 1993, Volume: 133, Issue:3 Topics: Animals; Calcium; Calcium Channels; Calpain; Cells, Cultured; Clenbuterol; Dose-Response Relationship, Drug; Dystrophin; Feedback; Glycoproteins; Kinetics; Leupeptins; Mice; Mice, Mutant Strains; Muscles; Muscular Dystrophy, Animal	1993
Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain research, 1993, Apr-23, Volume: 609, Issue:1-2 Topics: Animals; Blood Pressure; Calpain; Cells, Cultured; Glycoproteins; Hypoxia, Brain; Ischemic Attack, Transient; Leupeptins; Male; Neurons; Prosencephalon; Rats; Rats, Wistar	1993
Neuromuscular recovery after peripheral nerve repair: effects of an orally-administered peptide in a primate model. Journal of reconstructive microsurgery, 1995, Volume: 11, Issue:6 Topics: Administration, Oral; Animals; Biological Availability; Calpain; Cebus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Leupeptins; Male; Median Nerve; Microsurgery; Motor Neurons; Muscle, Skeletal; Nerve Regeneration; Neural Conduction; Neuromuscular Junction; Protease Inhibitors; Wound Healing	1995
Stabilisation of neuromuscular junctions by leupeptin increases motor unit size in partially denervated rat muscles. Brain research. Developmental brain research, 1995, Sep-29, Volume: 88, Issue:2 Topics: Animals; Calpain; Cell Size; Leupeptins; Motor Neurons; Muscle Denervation; Nerve Endings; Neuromuscular Junction; Rats; Rats, Wistar	1995
ATP is required in platelet serotonin exocytosis for protein phosphorylation and priming of secretory vesicles docked on the plasma membrane. Journal of cell science, 1996, Volume: 109 ( Pt 1) Topics: Adenosine Triphosphate; Animals; Blood Platelets; Calcium; Calpain; Cattle; Cell Membrane; Culture Media; Cytoplasmic Granules; Exocytosis; Leupeptins; Magnesium; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Serotonin	1996
Myoblast fusion requires fibronectin degradation by exteriorized m-calpain. Experimental cell research, 1997, Sep-15, Volume: 235, Issue:2 Topics: Animals; Calpain; Cell Fusion; Cells, Cultured; Cysteine Proteinase Inhibitors; Fibronectins; Leupeptins; Muscle, Skeletal; Peptide Fragments; Protease Inhibitors; Rabbits; Rats; Rats, Wistar	1997
Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes. Shock (Augusta, Ga.), 1998, Volume: 10, Issue:4 Topics: Adenosine Triphosphate; Animals; Calcium; Calpain; Cathepsin B; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Deoxyglucose; Dexamethasone; Leucine; Leupeptins; Methylamines; Mifepristone; Multienzyme Complexes; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteins; Rats; Tyrosine; Ubiquitins	1998
Leupeptin protects sensory hair cells from acoustic trauma. Neuroreport, 1999, Mar-17, Volume: 10, Issue:4 Topics: Animals; Antineoplastic Agents; Calpain; Carboplatin; Chinchilla; Enzyme Inhibitors; Hair Cells, Auditory; Hearing Disorders; Hearing Loss, Noise-Induced; Immunohistochemistry; Leupeptins; Organ of Corti	1999
Stabilizing neuromuscular contacts reduces motoneuron death caused by paralysis of muscles in neonatal rats. Neuroscience, 1999, Volume: 93, Issue:3 Topics: Animals; Animals, Newborn; Bungarotoxins; Calpain; Cell Count; Cell Survival; Cholinergic Antagonists; Isometric Contraction; Leupeptins; Motor Neurons; Muscle, Skeletal; Neuromuscular Junction; Neurotoxins; Paralysis; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic	1999
Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition. Muscle & nerve, 2000, Volume: 23, Issue:1 Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Histocytochemistry; Leupeptins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Microscopy, Electron; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Necrosis	2000
Effect of protease inhibitors on angiotensin-converting enzyme activity in human T-lymphocytes. American journal of hypertension, 2000, Volume: 13, Issue:5 Pt 1 Topics: Adult; Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Calpain; Captopril; Cathepsins; Chymotrypsin; Cysteine Proteinase Inhibitors; Humans; Leucine; Leupeptins; Lisinopril; Lymphocyte Activation; Male; Oligopeptides; Peptidyl-Dipeptidase A; Protease Inhibitors; T-Lymphocytes	2000
[Demonstration of secondary free radicals and the role of calpain in functional changes associated with the myocardial ischemia-reperfusion sequence]. Archives des maladies du coeur et des vaisseaux, 2000, Volume: 93, Issue:8 Topics: Animals; Antioxidants; Calcium-Binding Proteins; Calpain; Catalase; Cathepsins; Cyclic N-Oxides; Cysteine Proteinase Inhibitors; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Leupeptins; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrogen Oxides; Oxidative Stress; Phycocyanin; Rats; Rats, Wistar; Spin Labels; Superoxides; Time Factors	2000
Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway. Biochemical and biophysical research communications, 2001, Jul-20, Volume: 285, Issue:3 Topics: Acetylcysteine; Adenine; Alcohol Dehydrogenase; Animals; Calpain; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Electrophoresis, Polyacrylamide Gel; Hepatocytes; Leupeptins; Liver; Lysosomes; Male; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitins	2001
Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hearing research, 2002, Volume: 164, Issue:1-2 Topics: Animals; Anti-Bacterial Agents; Calpain; Cochlea; Dose-Response Relationship, Drug; Gentamicins; Hair Cells, Auditory; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Leupeptins; Mice; Microscopy, Electron; Organ Culture Techniques; Saccule and Utricle; Semicircular Canals; Vestibule, Labyrinth	2002
Opening of ligand-gated cation channel families by calpain inhibitors. FEBS letters, 2002, Apr-24, Volume: 517, Issue:1-3 Topics: Amino Acid Sequence; Animals; Calcium; Calcium Channels; Calcium-Binding Proteins; Calpain; Cell Membrane Permeability; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine Proteinase Inhibitors; Electrophysiology; Ion Channel Gating; Leupeptins; Ligands; Membrane Proteins; Molecular Sequence Data; Patch-Clamp Techniques; Receptors, Drug; Transfection; TRPP Cation Channels	2002
Neuroprotection of vestibular sensory cells from gentamicin ototoxicity obtained using nitric oxide synthase inhibitors, reactive oxygen species scavengers, brain-derived neurotrophic factors and calpain inhibitors. Acta oto-laryngologica, 2003, Volume: 123, Issue:1 Topics: Animals; Brain-Derived Neurotrophic Factor; Calpain; Cell Survival; Free Radical Scavengers; Gentamicins; Guinea Pigs; Hair Cells, Vestibular; In Vitro Techniques; Leupeptins; Methionine; Microscopy, Fluorescence; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Reactive Oxygen Species	2003
In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. Cellular and molecular biology (Noisy-le-Grand, France), 2002, Volume: 48 Online Pub Topics: Antioxidants; Calpain; Electron Spin Resonance Spectroscopy; Glycoproteins; Kinetics; Leupeptins; Phycocyanin	2002
Calpain-mediated AQP2 proteolysis in inner medullary collecting duct. Biochemical and biophysical research communications, 2003, Mar-28, Volume: 303, Issue:1 Topics: Animals; Aquaporin 2; Aquaporin 6; Aquaporins; Calcium; Calcium-Binding Proteins; Calpain; Caseins; Cysteine Proteinase Inhibitors; Dextrans; Dihydrotachysterol; Dose-Response Relationship, Drug; Down-Regulation; Endosomes; Flow Cytometry; Immunoblotting; Immunohistochemistry; Kidney Tubules, Collecting; Leupeptins; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Trypsin	2003
Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity. Acta oto-laryngologica, 2003, Volume: 123, Issue:4 Topics: Animals; Anti-Bacterial Agents; Apoptosis; Calpain; Caspase Inhibitors; Cathepsins; Cysteine Proteinase Inhibitors; Gentamicins; Guinea Pigs; Hair Cells, Vestibular; Leupeptins; Oligopeptides; Organ Culture Techniques; Pilot Projects	2003
The calpain-calpastatin system and the calcium paradox in the isolated perfused pigeon heart. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2003, Volume: 13, Issue:3 Topics: Animals; Antipain; Barium; Calcium; Calcium-Binding Proteins; Calpain; Cobalt; Columbidae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylmaleimide; Heart; In Vitro Techniques; Kinetics; Leucine; Leupeptins; Magnesium; Manganese; Molecular Weight; Myocardium; Nickel; Phenylmethylsulfonyl Fluoride; Strontium; Time Factors	2003
Characterization of a new p94-like calpain form in human lymphocytes. The Biochemical journal, 2003, Nov-01, Volume: 375, Issue:Pt 3 Topics: Calcium; Calpain; Catalysis; Cloning, Molecular; Cysteine Proteinase Inhibitors; DNA, Complementary; Enzyme Activation; Erythrocytes; Humans; Immunoblotting; Isoenzymes; Leupeptins; Lymphocytes; Neutrophils; Sequence Analysis, DNA	2003
Calpain-2 as a target for limiting prostate cancer invasion. Cancer research, 2003, Aug-01, Volume: 63, Issue:15 Topics: Animals; Calpain; Cell Movement; Cysteine Proteinase Inhibitors; Down-Regulation; ErbB Receptors; Glycoproteins; Humans; Leupeptins; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Oligonucleotides, Antisense; Prostatic Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2003
Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organization. Experimental cell research, 2004, Jan-01, Volume: 292, Issue:1 Topics: Animals; Calcium-Binding Proteins; Calpain; Cell Adhesion; Cell Fusion; Cell Line; Cell Movement; Clone Cells; Cysteine Proteinase Inhibitors; Cytoskeleton; Dipeptides; Dose-Response Relationship, Drug; Glucosidases; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Proteins; Mice; Muscle Fibers, Skeletal; Myoblasts; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides; Phosphoproteins; Stress Fibers	2004
Partial and delayed release of troponin-I compared with the release of lactate dehydrogenase from necrotic cardiomyocytes. Pflugers Archiv : European journal of physiology, 2004, Volume: 448, Issue:2 Topics: Animals; Antimetabolites; Calpain; Cysteine Proteinase Inhibitors; Deoxyglucose; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; In Vitro Techniques; L-Lactate Dehydrogenase; Leupeptins; Male; Myocytes, Cardiac; Necrosis; Rats; Rats, Wistar; Sodium Cyanide; Troponin I	2004
Calpain and caspase-3 inhibitors reduce infarct size and post-ischemic apoptosis in rat heart without modifying contractile recovery. Cellular and molecular biology (Noisy-le-Grand, France), 2003, Volume: 49 Online Pub Topics: Animals; Apoptosis; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Glycoproteins; Heart; Ischemia; Kinetics; L-Lactate Dehydrogenase; Leupeptins; Muscle Contraction; Myocardium; Rats; Reperfusion	2003
Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration. Neuroscience, 2004, Volume: 125, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calpain; Cell Count; Cell Survival; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agents; Female; Immunohistochemistry; Isometric Contraction; Leupeptins; Male; Microtubule-Associated Proteins; Motor Neuron Disease; Motor Neurons; Muscle Fatigue; Muscle Fibers, Skeletal; Muscle, Skeletal; Myosins; Nerve Crush; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Spinal Cord; Staining and Labeling; Time Factors	2004
Sustained-release delivery of leupeptin in the chinchilla: hearing results. The international tinnitus journal, 2003, Volume: 9, Issue:2 Topics: Animals; Auditory Threshold; Calpain; Chinchilla; Cysteine Proteinase Inhibitors; Delayed-Action Preparations; Dose-Response Relationship, Drug; Ear, Inner; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Leupeptins; Models, Animal; Perilymph; Time Factors	2003
The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic-reperfused heart. Journal of molecular and cellular cardiology, 2004, Volume: 37, Issue:1 Topics: Animals; Blotting, Western; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Calpain; Calsequestrin; Cyclic AMP-Dependent Protein Kinases; Cytosol; Down-Regulation; Leupeptins; Male; Myocardial Contraction; Myocardium; Perfusion; Phosphorylation; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Time Factors	2004
Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site. Journal of molecular biology, 2004, Nov-05, Volume: 343, Issue:5 Topics: Amino Acid Sequence; Animals; Calpain; Catalytic Domain; Cathepsin K; Cathepsins; Crystallization; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Glycoproteins; Leucine; Leupeptins; Molecular Sequence Data; Papain; Protein Structure, Tertiary; Rats	2004
Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity. The Tohoku journal of experimental medicine, 2006, Volume: 209, Issue:2 Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Apoptosis; Biomarkers; Calpain; Cell Survival; Cochlea; Dose-Response Relationship, Drug; Drug Antagonism; Hair Cells, Auditory, Inner; Leupeptins; Mice; Mice, Inbred C57BL; Neomycin; Organ Culture Techniques; Phalloidine; Protein Synthesis Inhibitors	2006
Calpain inhibitors delay injury-induced apoptosis in adult mouse spinal cord motor neurons. Neuroreport, 2006, May-29, Volume: 17, Issue:8 Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Calpain; Caspases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Female; Glycoproteins; Immunohistochemistry; Leupeptins; Mice; Motor Neurons; Nerve Degeneration; Organ Culture Techniques; Spinal Cord; Spinal Cord Injuries; Time Factors	2006
Calpain inhibition protects spinal motoneurons from the excitotoxic effects of AMPA in vivo. Neurochemical research, 2008, Volume: 33, Issue:8 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Calpain; Cysteine Proteinase Inhibitors; Excitatory Amino Acid Agonists; Leupeptins; Male; Motor Neurons; Rats; Rats, Wistar; Rotarod Performance Test; Spinal Cord	2008
Role of the calcium-calpain pathway in cytoskeletal damage after eccentric contractions. Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:1 Topics: Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Cytoskeleton; Electric Stimulation; Extracellular Space; Immunohistochemistry; In Vitro Techniques; Leupeptins; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Signal Transduction	2008
Calpain-1 is required for hydrogen peroxide-induced myotube atrophy. American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:2 Topics: Animals; Calpain; Caspase 3; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Hydrogen Peroxide; Leupeptins; Mice; Muscle Proteins; Muscular Atrophy; Myoblasts, Skeletal; Oxidative Stress; RNA Interference; Sarcomeres; Superoxide Dismutase; Time Factors; Transfection	2009
Leupeptin-based inhibitors do not improve the mdx phenotype. American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 299, Issue:5 Topics: Animals; Biomarkers; Calcium-Binding Proteins; Calpain; Creatine Kinase; Cysteine Proteinase Inhibitors; Diaphragm; Disease Models, Animal; Dose-Response Relationship, Drug; Genotype; Leupeptins; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle Strength; Muscular Dystrophy, Duchenne; Necrosis; Phenotype; Proteasome Endopeptidase Complex; Time Factors	2010
Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction. The FEBS journal, 2010, Volume: 277, Issue:21 Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Biocatalysis; Blotting, Western; Calpain; Catalytic Domain; Cysteine Proteinase Inhibitors; Endosomal Sorting Complexes Required for Transport; Ethylmaleimide; Glutathione Transferase; Green Fluorescent Proteins; HEK293 Cells; Humans; Hydrolysis; Immunoprecipitation; Leucine; Leupeptins; Mutation; Oncogene Proteins; Protein Binding; Recombinant Fusion Proteins; Transfection	2010
Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Aug-15, Volume: 32, Issue:33 Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Calcium; Calcium Ionophores; Calpain; Cycloheximide; Cysteine Proteinase Inhibitors; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Emetine; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Ionomycin; K Cl- Cotransporters; Leupeptins; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Protein Synthesis Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Statistics, Nonparametric; Symporters; Valine	2012
Profiling drug-induced cell death pathways in the zebrafish lateral line. Apoptosis : an international journal on programmed cell death, 2013, Volume: 18, Issue:4 Topics: Animals; Antioxidants; Benzamidines; Calpain; Caspase Inhibitors; Cell Death; Cells, Cultured; Cisplatin; Cross-Linking Reagents; Gentamicins; Guanidines; Hair Cells, Auditory, Inner; Lateral Line System; Leupeptins; Methionine; Neomycin; Oligopeptides; Protease Inhibitors; Protein Synthesis Inhibitors; Reactive Oxygen Species; Zebrafish	2013
Inhibition of calpains fails to improve regeneration through a peripheral nerve conduit. Neuroscience letters, 2014, Apr-30, Volume: 566 Topics: Action Potentials; Animals; Calpain; Cysteine Proteinase Inhibitors; Leupeptins; Male; Muscle, Skeletal; Nerve Regeneration; Neural Conduction; Rats, Sprague-Dawley; Sciatic Nerve	2014
Effects of copper overload in P19 neurons: impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2014, Volume: 27, Issue:6 Topics: Adenosine Triphosphate; Animals; Apoptosis; Apoptosis Regulatory Proteins; Calpain; Caspases; Cell Line, Tumor; Chelating Agents; Chromatin; Copper Sulfate; Dizocilpine Maleate; Gene Expression Regulation; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Leupeptins; Mice; Neoplasm Proteins; Neurons; Nifedipine; Oxidation-Reduction; Oxidative Stress; Protease Inhibitors; Protein Kinase Inhibitors; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Teratocarcinoma	2014
Controlled cortical impact-induced neurodegeneration decreases after administration of the novel calpain-inhibitor Gabadur. Brain research bulletin, 2018, Volume: 142 Topics: Animals; Brain; Brain Injuries, Traumatic; Calpain; Disease Models, Animal; Glycoproteins; Leupeptins; Molecular Structure; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Pregabalin; Rats, Sprague-Dawley	2018
Insertion sequence 1 from calpain-3 is functional in calpain-2 as an internal propeptide. The Journal of biological chemistry, 2018, 11-16, Volume: 293, Issue:46 Topics: Calcium; Calcium-Binding Proteins; Calpain; Cysteine Proteinase Inhibitors; DNA Transposable Elements; Isoenzymes; Leucine; Leupeptins; Muscle Proteins; Protein Conformation; Proteolysis; Recombinant Proteins	2018