leukotriene-e4 has been researched along with levocabastine* in 1 studies
1 other study(ies) available for leukotriene-e4 and levocabastine
Article | Year |
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Effects of levocabastine on lipid mediator release from guinea pig lung fragments.
The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10(-4) M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release. Topics: Animals; Antigens; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Leukotriene C4; Leukotriene E4; Lung; Male; Piperidines; Thromboxane B2 | 1999 |