leukotriene-e4 and imidazole

leukotriene-e4 has been researched along with imidazole* in 2 studies

Other Studies

2 other study(ies) available for leukotriene-e4 and imidazole

Article	Year
Effect of intravenously administered lipoxygenase metabolites on rat tracheal mucous gel layer thickness. International archives of allergy and applied immunology, 1989, Volume: 90, Issue:3 The effect of intravenous injections of 5-, 12- and 15-hydroxyeicosatetraenoic acids (HETE), leukotrienes D4 and E4 (LTD4, LTE4) on tracheal mucous gel layer (TMGL) thickness was assessed in rats. When administered in doses ranging from 0.03 pg to 33 ng per rat, the lipoxygenase metabolites produced significant increases in TMGL thickness. The order of potency of the metabolites was 15-HETE greater than 12-HETE greater than or equal to 5-HETE greater than LTD4 greater than or equal to LTE4. Imidazole (31.6 mg/kg), intravenously, significantly decreased this response. These findings suggest that the mono-HETEs, especially 15-HETE, may be important modulators of airway mucus in the rat. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Injections, Intravenous; Leukotriene E4; Leukotrienes; Mucous Membrane; Mucus; Rats; SRS-A; Trachea	1989
The actions of leukotrienes B4, C4, D4 and E4 in the lung. Agents and actions. Supplements, 1983, Volume: 13 Topics: Animals; Guinea Pigs; Humans; Imidazoles; In Vitro Techniques; Indomethacin; Leukotriene B4; Leukotriene E4; Lung; Muscle Contraction; Muscle, Smooth; Rabbits; Rats; SRS-A	1983

Article

Year

Effect of intravenously administered lipoxygenase metabolites on rat tracheal mucous gel layer thickness.

International archives of allergy and applied immunology, 1989, Volume: 90, Issue:3

The effect of intravenous injections of 5-, 12- and 15-hydroxyeicosatetraenoic acids (HETE), leukotrienes D4 and E4 (LTD4, LTE4) on tracheal mucous gel layer (TMGL) thickness was assessed in rats. When administered in doses ranging from 0.03 pg to 33 ng per rat, the lipoxygenase metabolites produced significant increases in TMGL thickness. The order of potency of the metabolites was 15-HETE greater than 12-HETE greater than or equal to 5-HETE greater than LTD4 greater than or equal to LTE4. Imidazole (31.6 mg/kg), intravenously, significantly decreased this response. These findings suggest that the mono-HETEs, especially 15-HETE, may be important modulators of airway mucus in the rat.

Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Injections, Intravenous; Leukotriene E4; Leukotrienes; Mucous Membrane; Mucus; Rats; SRS-A; Trachea

1989

The actions of leukotrienes B4, C4, D4 and E4 in the lung.

Agents and actions. Supplements, 1983, Volume: 13

Topics: Animals; Guinea Pigs; Humans; Imidazoles; In Vitro Techniques; Indomethacin; Leukotriene B4; Leukotriene E4; Lung; Muscle Contraction; Muscle, Smooth; Rabbits; Rats; SRS-A

1983