leukotriene-e4 and arachidic-acid

Group 2 innate lymphoid cells (ILC2s) are a potential innate source of type 2 cytokines in the pathogenesis of allergic conditions. Epithelial cytokines (IL-33, IL-25, and thymic stromal lymphopoietin [TSLP]) and mast cell mediators (prostaglandin D. We sought to determine the role of cysLTs and their relationship with other ILC2 stimulators in the activation of human ILC2s.. For ex vivo studies, fresh blood from patients with atopic dermatitis and healthy control subjects was analyzed with flow cytometry. For in vitro studies, ILC2s were isolated and cultured. The effects of cysLTs, PGD. Human ILC2s expressed the LT receptor CysLT. CysLTs, particularly LTE

Topics: Adult; Cells, Cultured; Cytokines; Dermatitis, Atopic; Eicosanoic Acids; Epithelial Cells; Female; Humans; Immunity, Innate; Leukotriene E4; Lymphocytes; Male; Mast Cells; Prostaglandin D2; Th2 Cells